Search Result

Isoforms Recommended:	Bcl-2

Results for "

Bcl‐2

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Bcl-2 Family (275) 5-HT Receptor (1) ADC Linker (1) Adrenergic Receptor (2) Akt (21) AMPK (1) Anaplastic lymphoma kinase (ALK) (1) Androgen Receptor (1) Antibiotic (2) Apoptosis (197) ASK1 (2) Autophagy (29) Bacterial (3) Bcr-Abl (2) Beclin1 (2) Biochemical Assay Reagents (5) Bombesin Receptor (1) Btk (1) c-Met/HGFR (1) c-Myc (4) Cadherin (2) Calcium Channel (1) Cannabinoid Receptor (1) Carbonic Anhydrase (3) Caspase (81) CDK (9) Checkpoint Kinase (Chk) (1) Cholinesterase (ChE) (1) COX (5) Cyclin G-associated Kinase (GAK) (2) Cytochrome P450 (4) Dimethylargininase (DDAH) (1) DNA/RNA Synthesis (4) Dopamine β-hydroxylase (2) Drug Derivative (1) Drug Metabolite (2) E1/E2/E3 Enzyme (3) EAAT (1) EGFR (10) Endogenous Metabolite (7) Epigenetic Reader Domain (3) ERK (9) Estrogen Receptor/ERR (1) FAK (1) Fat Mass and Obesity-associated Protein (FTO) (1) Ferroptosis (4) FGFR (2) FLT3 (1) Fungal (7) FXR (2) G-quadruplex (1) Glutathione Peroxidase (2) Glutathione S-transferase (1) Glycosidase (2) GSK-3 (1) HBV (1) HCV (5) HDAC (6) HIF/HIF Prolyl-Hydroxylase (2) Histone Methyltransferase (2) HIV (1) HSP (4) HSV (4) IAP (3) iGluR (1) Indoleamine 2,3-Dioxygenase (IDO) (1) Influenza Virus (4) Insulin Receptor (1) Interleukin Related (6) Isotope-Labeled Compounds (5) JAK (2) JNK (13) Keap1-Nrf2 (2) Lactate Dehydrogenase (2) Ligands for E3 Ligase (1) MAP3K (1) MDM-2/p53 (24) METTL3 (2) MicroRNA (1) Microtubule/Tubulin (14) Mitochondrial Metabolism (1) Mitophagy (1) MMP (5) Molecular Glues (1) Monoamine Oxidase (1) mRNA (3) mTOR (7) Na+/K+ ATPase (1) Necroptosis (3) NF-κB (22) Notch (2) P-glycoprotein (5) p38 MAPK (22) Parasite (8) PARP (19) PGE synthase (1) PI3K (12) Potassium Channel (1) PPAR (4) PROTACs (12) Protease Activated Receptor (PAR) (1) Pyroptosis (1) Raf (1) RAR/RXR (1) Ras (2) Reactive Oxygen Species (ROS) (31) Reference Standards (25) ROS Kinase (2) Serpin (1) Sirtuin (1) Small Interfering RNA (siRNA) (24) SOD (3) Src (2) STAT (7) Survivin (1) Tau Protein (1) TGF-beta/Smad (2) TGF-β Receptor (1) Thymidylate Synthase (1) TNF Receptor (6) Topoisomerase (6) TRP Channel (3) ULK (1) VD/VDR (1) VEGFR (10) Virus Protease (1) β-catenin (1)
By Research Areas:	Cancer (307) Cardiovascular Disease (24) Endocrinology (4) Infection (26) Inflammation/Immunology (40) Metabolic Disease (7) Neurological Disease (30)
Oligonucleotides:	Aptamers (1) Rat Pre-designed siRNA Sets (7) Mouse Pre-designed siRNA Sets (7) mRNA (3) Human Pre-designed siRNA Sets (10) Polymers (1) Antisense Oligonucleotides (6) Cholesterol (1) siRNAs (24)

385

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Targets Recommended: Bcl-2 Family

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-125876

*PROTAC Bcl2* degrader-1** 1 Publications Verification	PROTACs Bcl-2 Family	Cancer
PROTAC Bcl2 degrader-1 (Compound C5) is a PROTAC based on Cereblon ligand, which potently and selectively induces the degradation of *Bcl-2* (IC₅₀, 4.94 μM; DC₅₀, 3.0 μM) and Mcl-1 (IC₅₀, 11.81 μM) by introducing the E3 ligase cereblon (CRBN)-binding ligand pomalidomide to Mcl-1/Bcl-2 dual inhibitor Nap-1 (Blue: CRBN ligand, Black: linker；Pink: Mcl-1/Bcl-2 inhibitor, Nap-1).

HY-135273

A-1211212 BCL2-IN-1	Bcl-2 Family	Cancer
A-1211212 (BCL2-IN-1), a chemical probe, is a potent *Bcl-2* inhibitor. BCL2-IN-1 binds Bcl-2 with a K_i of <0.01 nM .

HY-RS01417

BCL2 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA) Bcl-2 Family	Others
BCL2 Rat Pre-designed siRNA Set A contains three designed siRNAs for BCL2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

BCL2 Rat Pre-designed siRNA Set A BCL2 Rat Pre-designed siRNA Set A

HY-RS01415

BCL2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA) Bcl-2 Family	Others
BCL2 Human Pre-designed siRNA Set A contains three designed siRNAs for BCL2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

BCL2 Human Pre-designed siRNA Set A BCL2 Human Pre-designed siRNA Set A

HY-RS01416

Bcl2 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA) Bcl-2 Family	Others
Bcl2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Bcl2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Bcl2 Mouse Pre-designed siRNA Set A Bcl2 Mouse Pre-designed siRNA Set A

HY-143873

Bcl-2-IN-5	Bcl-2 Family	Cancer
Bcl-2-IN-5 is a *BCL-2* inhibitor with IC₅₀s of 0.12 nM, 0.14 nM and 0.22 nM for *Bcl-2* wild type, Bcl-2 D103Y and Bcl-2 G101V, respectively. Bcl-2-IN-5 inhibits the cell growth with IC₅₀ values of 0.2 nM and 0.44 nM for Bcl 2-G101V knock-in RS4; 11 and RS4; 11 cells, respectively (WO2021208963A1; Example 155) .

HY-131247

Bcl-2-IN-2	Bcl-2 Family	Inflammation/Immunology Cancer
Bcl-2-IN-2 is a potent and selective *Bcl-2* inhibitor with an IC₅₀ of 0.034 nM and also inhibits Bcl-xL with an IC₅₀ of 43 nM, showing >1000-fold selectivity for Bcl-2 over Bcl-xL .

HY-149009

Bcl-2-IN-9	Bcl-2 Family Apoptosis	Cancer
Bcl-2-IN-9 is a novel proapoptotic *Bcl-2* inhibitor with IC₅₀ value of 2.9 μM and low cytotoxic. Bcl-2-IN-9 mediates apoptosis by down-regulating expression of Bcl-2 in cancer cells and has a high selectivity against leukemia cells .

HY-163309

Bcl-2-IN-19	Bcl-2 Family	Cancer
Bcl-2-IN-19 (compound 27) is a potent *Bcl-2* inhibitor for targeting breast cancer .

HY-136714

Bcl-2-IN-3	Bcl-2 Family	Cancer
Bcl-2-IN-3 (Compound 10) is a *Bcl-2* inhibitor. Bcl-2-IN-3 can be used for the research of cancer .

HY-149623

Bcl-2-IN-13	Bcl-2 Family	Cancer
Bcl-2-IN-13 is a *Bcl-2* inhibitor with an IC₅₀ value of 17 nM. Bcl-2-IN-13 can be used in cancer research .

HY-169083

Bcl-2-IN-22	Apoptosis Bcl-2 Family	Cancer
Bcl-2-IN-22 (compound 1) is a gold(I) NHC complex with anticancer activity. Bcl-2-IN-22 induces apoptosis via the mitochondrial pathway with an IC₅₀ value of 0.014 μM. In addition, Bcl-2-IN-22 targets *BCL-2* family members and exhibits pro-apoptosis and resensitization properties in multidrug-resistant leukemia cells that overexpress *BCL-2* .

HY-149622

Bcl-2-IN-12	Bcl-2 Family	Cancer
Bcl-2-IN-12 (Compound 1) is a *Bcl-2* inhibitor (IC₅₀: 6 nM). Bcl-2-IN-12 can be used for cancer research .

HY-149624

Bcl-2-IN-14	Bcl-2 Family	Cancer
Bcl-2-IN-14 (Compound 13c) is a *BCL-2* inhibitor with an IC₅₀ value of 0.471 μM. Bcl-2-IN-14 can be used in cancer research .

HY-149625

Bcl-2-IN-15	Bcl-2 Family	Cancer
Bcl-2-IN-15 (Compound 13d)) is a *Bcl-2* inhibitor (IC₅₀: 363 nM). Bcl-2-IN-15 inhibits the proliferation ofNCI leukemia cancer cell line .

HY-149436

*CDK2/Bcl2-IN-1*	CDK	Cancer
CDK2/Bcl2-IN-1 (compound 1), a saponin and a CDK-2 inhibitor (IC₅₀=117.6 nM) with promising cytotoxicity against cancer cells. CDK2/Bcl2-IN-1 also inhibits Bcl-2, and induces apoptosis in A549 lung cancer cells .

HY-160108

Bcl-2-IN-17	Bcl-2 Family	Others
Bcl-2-IN-17 is a *Bcl2* inhibitor and can be used for the research of diseases associated with Bcl anti-apoptotic protein .

HY-153953

Bcl-2-IN-11	Bcl-2 Family	Cancer
Bcl-2-IN-11 (compound 6) is a potent and selective *Bcl-2* activity inhibitor, with an IC₅₀ of 0.9 nM. Bcl-2-IN-11 shows weak inhibition of Bcl-xl (IC₅₀ > 1000 nM). Bcl-2-IN-11 can be used for the research of a variety of cancers caused by abnormal overexpression of Bcl-2 family proteins: especially malignant hematologic diseases of acute lymphoid leukemia, etc. Bcl-2-IN-11 can also avoid toxic side effects caused by Bcl-xl inhibition, such as thrombocytopenia .

HY-163308

Bcl-2-IN-18	Bcl-2 Family	Cancer
Bcl-2-IN-18 (Compound 23) is a breast cancer *Bcl-2* inhibitor with a IC₅₀ value of 4.7 μM for MCF-7. Bcl-2-IN-18 has antitumor activity .

HY-162820

Bcl-2-IN-21	Bcl-2 Family	Cancer
Bcl-2-IN-21 (compound C1) is an iridium compound with anticancer activity that targets and inhibits *Bcl-2. Bcl-2-IN-21* inhibits colony formation of cancer cells and induces elevated levels of Bax and caspase 3 .

HY-144791

Bcl-2-IN-6	Bcl-2 Family MDM-2/p53 Caspase Apoptosis	Cancer
Bcl-2-IN-6 (compound 10) is a potent *Bcl-2* (B-cell lymphoma-2) inhibitor. Bcl-2-IN-7 down-regulates the expression of Bcl-2, and increases the expression of p53, Bax, and caspase-7 mRNA. Bcl-2-IN-7 induces cell cycle arrest and apoptosis in breast cancer MCF-7 cells. Bcl-2-IN-7 shows good anticancer activity, with IC₅₀ values of 20.91, 22.30, 42.29, and 48.00 μM against MCF-7, LoVo, HepG2, and A549 cell lines, respectively .

HY-144792

Bcl-2-IN-7	Bcl-2 Family MDM-2/p53 Caspase Apoptosis	Cancer
Bcl-2-IN-7 (compound 6) is a potent *Bcl-2* (B-cell lymphoma-2) inhibitor. Bcl-2-IN-7 down-regulates the expression of Bcl-2, and increases the expression of p53, Bax, and caspase-7 mRNA. Bcl-2-IN-7 induces cell cycle arrest and apoptosis in breast cancer MCF-7 cells. Bcl-2-IN-7 shows good anticancer activity, with IC₅₀ values of 20.17, 22.64, 45.57, and 51.50 μM against MCF-7, LoVo, HepG2, and A549 cell lines, respectively .

HY-176219

Bcl-2-IN-23	Bcl-2 Family Apoptosis Necroptosis	Cancer
Bcl-2-IN-23 (compound 5) is a selective inhibitor targeting *Bcl-2. The IC₅₀ of Bcl-2-IN-23* in HTB-140, HeLa and SW620 cells is 25.7-33.7 μM. Bcl-2-IN-23 can non-covalently competitively bind to Bcl-2 protein, significantly reduce its expression, and induce late apoptosis and necroptosis of cancer cells. Bcl-2-IN-23 enhances the sensitivity of cancer cells to apoptosis and reduces the release of IL-6 inflammatory factors by disrupting the Bcl-2-mediated mitochondrial apoptosis inhibition pathway. Bcl-2-IN-23 can be used for anti-apoptosis research of malignant tumors such as melanoma, cervical cancer, and colorectal cancer .

HY-129702

*MCL-1/BCL-2-IN-4*	Bcl-2 Family	Cancer
MCL-1/BCL-2-IN-4 (Compound 7) is a potent and selective Mcl-1 and *Bcl-2* dual inhibitor .

HY-129700

*MCL-1/BCL-2-IN-2*	Bcl-2 Family	Cancer
MCL-1/BCL-2-IN-2 (Compound 6) is a potent and selective Mcl-1 and *Bcl-2* dual inhibitor .

HY-174403

*c-MYC/BCL2* ligand 1 iodide**	Bcl-2 Family c-Myc Apoptosis Caspase	Cancer
c-MYC/BCL2 ligand 1 iodide is a dual-targeting *c-MYC/Bcl-2* G4 ligand with K_d values of 0.90 μM (c-MYC G4) and 0.56 μM (Bcl-2** G4). c-MYC/BCL2 ligand 1 iodide inhibits c-MYC and *Bcl-2* gene transcription by binding to G4-forming sequences and downregulates their protein expression. c-MYC/BCL2 ligand 1 iodide inhibits suppresses migration, induces caspase-dependent apoptosis, and triggers cell cycle G1 arrest in MCF-7 cells. c-MYC/BCL2 ligand 1 iodide significantly suppresses tumor growth in a 4T1 syngeneic model with no observable toxicity. c-MYC/BCL2 ligand 1 iodide can be used for the research of breast cancer.

HY-143872

Bcl-2-IN-4	Bcl-2 Family	Cancer
Bcl-2-IN-4 is a potent, orally active and selective Bcl-2 inhibitor with an IC₅₀ of 1.5 nM. Bcl-2-IN-4 displays >200-fold selectivity over Bcl-xL (IC₅₀ of 411 nM). Bcl-2-IN-4 inhibits RS4; 11 cell proliferation with an IC₅₀ of 2.7 nM (WO2021180040A1; compound 2) .

HY-150540

Bcl-2-IN-10	Bcl-2 Family Apoptosis	Cancer
Bcl-2-IN-10 is an active *Bcl-2* inhibitor that can release up to four nitric oxide (NO) molecules. Bcl-2-IN-10 has cytotoxic activities against cancer cells, such as human leukemia, breast cancer and lung cancer. Bcl-2-IN-10 induces cell apopotosis and arrest cell cycle of G2/M phase, and can be used in cancer-related research .

HY-129701

*MCL-1/BCL-2-IN-3*	Bcl-2 Family	Cancer
MCL-1/BCL-2-IN-3 (Compound 2) is a potent and selective Mcl-1 and *Bcl-2* dual inhibitor with IC₅₀s of 5.95 and 4.78 μM, respectively .

HY-144428

Bcl-2/Mcl-1-IN-2	Bcl-2 Family	Cancer
Bcl-2/Mcl-1-IN-2 (compound 2) is a *Bcl-2/Mcl-1* inhibitor, with K_is of 0.88 μM and 4.70 μM for Mcl-1 and **Bcl-2, *respectively. Bcl-2/Mcl-1-IN-2* can be used for the research of cancer .****

HY-144430

Bcl-2/Mcl-1-IN-1	Bcl-2 Family	Cancer
Bcl-2/Mcl-1-IN-1 (compound 3) is a *Bcl-2/Mcl-1* inhibitor, with K_is of 1.19 μM and 4.53 μM for Mcl-1 and **Bcl-2, *respectively. Bcl-2/Mcl-1-IN-1* can be used for the research of cancer .****

HY-144431

Bcl-2/Mcl-1-IN-3	Bcl-2 Family	Cancer
Bcl-2/Mcl-1-IN-3 (compound 1) is a *Bcl-2/Mcl-1* inhibitor, with K_is of 0.14 μM and 0.23 μM for Mcl-1 and **Bcl-2, *respectively. Bcl-2/Mcl-1-IN-3* can be used for the research of cancer .****

HY-129681

*MCL-1/BCL-2-IN-1*	Bcl-2 Family	Cancer
MCL-1/BCL-2-IN-2 (Compound Nap-1) is a potent and selective Mcl-1 and *Bcl-2* dual inhibitor with IC₅₀s of 4.45 and 3.18 μM, respectively .

HY-129179

Lisaftoclax 1 Publications Verification APG-2575; Bcl-2/Bcl-xl inhibitor 1	Bcl-2 Family	Cancer
Lisaftoclax (compound 6) is a dual *Bcl-2* and *Bcl-xl* inhibitor with anti-tumor activity, extracted from patent WO2018027097A1. Lisaftoclax exhibits IC₅₀ values of 2 nM and 5.9 nM for Bcl-2 and Bcl-xl, respectively .

HY-P990344

*Anti-Bcl-2* Antibody**	Bcl-2 Family	Inflammation/Immunology
The Anti-Bcl-2 Antibody is a humanized antibody expressed in CHO cells, targeting *Bcl-2. The Anti-Bcl-2* Antibody has a huIgG1 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 145.74 kDa. The isotype control for Anti-Bcl-2 Antibody can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001).

HY-159513

Bcl-2/Mcl-1-IN-4	Bcl-2 Family Apoptosis	Cancer
Bcl-2/Mcl-1-IN-4 (compound 20) is a dual inhibitor targeting *Bcl-2* (K_i=0.49 μM) and Mcl-1 (K_i=0.51 μM). Bcl-2/Mcl-1-IN-4 significantly inhibits cancer cell proliferation and effectively induces apoptosis in U937 cells. Bcl-2/Mcl-1-IN-4 can be used in cancer research .

HY-161415

BCL-xL/BCL-2 ligand 1	Ligands for E3 Ligase	Cancer
BCL-xL/BCL-2 ligand 1 (compound 72-1) is a *BCL-xL* and *BCL-2* protein ligand. BCL-xL/BCL-2 ligand 1 can be connected to the E3 ligase by a linker to form PROTACs (HY-161410) ^[2].

HY-161786

Bcl-2-IN-20	Bcl-2 Family Apoptosis Reactive Oxygen Species (ROS)	Cancer
Bcl-2-IN-20 (Compound 81) is an inhibitor for *Bcl-2* with IC₅₀ <10 μM (79.1% inhibition at 9 μM). Bcl-2-IN-20 exhibits cytotoxicity in SK-MEL-28 (IC₅₀>10 μM), A549 (IC₅₀=6.1 μM), HepG2 (IC₅₀>10 μM), MCF-7 (IC₅₀=8.9 μM), HCT116 (IC₅₀>10 μM) and HEK-293 (IC₅₀=14.1 μM). Bcl-2-IN-20 promotes the ROS production, induces apoptosis and DNA damage .

HY-118874

Oblimersen	Bcl-2 Family Apoptosis	Cancer
Oblimersen is a *BCL-2* inhibitor targeting BCL-2 RNA. Oblimersen specifically binds to the first six codons of the bcl-2 mRNA sequence, resulting in degradation of bcl-2 mRNA and induces apoptosis by down-regulating expression of Bcl-2. Oblimersen can be used for cancer research ^[2] .

HY-118874A

Oblimersen sodium	Apoptosis Bcl-2 Family	Cancer
Oblimersen sodium is a *BCL-2* inhibitor targeting BCL-2 RNA. Oblimersen sodium specifically binds to the first six codons of the bcl-2 mRNA sequence, resulting in degradation of bcl-2 mRNA and induces apoptosis by down-regulating expression of Bcl-2. Oblimersen sodium can be used for cancer research ^[2] .

HY-10087

Navitoclax 125+ Cited Publications ABT-263	Bcl-2 Family	Cancer
Navitoclax (ABT-263) is a potent and orally active Bcl-2 family protein inhibitor that binds to multiple anti-apoptotic Bcl-2 family proteins, such as Bcl-x_L, Bcl-2 and Bcl-w, with a K_i of less than 1 nM .

HY-10087A1

Navitoclax dihydrochloride ABT-263 dihydrochloride	Bcl-2 Family	Cancer
Navitoclax (ABT-263) dihydrochloride is an orally active *Bcl-2* inhibitor that binds to various *Bcl-2* family proteins, including *Bcl-xL, Bcl-2, and Bcl-w, with a K_i* value of less than 1 nM. Navitoclax dihydrochloride can be used in cancer research .

HY-161276

BFC1108	Apoptosis Bcl-2 Family	Cancer
BFC1108 is a small molecule Bcl-2 functional converter. BFC1108 induces a conformational change in Bcl-2, resulting in the exposure of its BH3 domain both in vitro and in vivo. BFC1108 effectively induces apoptosis in Bcl-2 expressing cancers. .

HY-12020

TW-37 4 Publications Verification	Bcl-2 Family	Cancer
TW-37 is a potent *Bcl-2* inhibitor with K_i values of 260, 290 and 1110 nM for Mcl-1, *Bcl-2* and *Bcl-xL*, respectively.

HY-123244

YC137	Bcl-2 Family Apoptosis	Cancer
YC137 is a potent *Bcl-2* antagonist with K_is of 1.3 μM and >100 μM for Bcl-2 and Bcl-xL when assayed in Bis-Tris buffer, respectively. YC137 inhibits the binding of the Bid BH3 peptide to Bcl-2, thus disrupting an interaction essential for the antiapoptotic activity of Bcl-2. YC137 selectively induces apoptosis of Bcl-2-dependent cells. YC137 has the potential for breast cancer research ^[2].

HY-10087S

Navitoclax-d8 1 Publications Verification	Bcl-2 Family	Cancer
Navitoclax-d₈ is the deuterium labeled Navitoclax. Navitoclax (ABT-263) is a potent and orally active Bcl-2 family protein inhibitor that binds to multiple anti-apoptotic Bcl-2 family proteins, such as Bcl-xL, Bcl-2 and Bcl-w, with a Ki of less than 1 nM .

HY-10087R

Navitoclax (Standard) ABT-263 (Standard)	Reference Standards Bcl-2 Family	Cancer
Navitoclax (Standard) is the analytical standard of Navitoclax. This product is intended for research and analytical applications. Navitoclax (ABT-263) is a potent and orally active Bcl-2 family protein inhibitor that binds to multiple anti-apoptotic Bcl-2 family proteins, such as Bcl-xL, Bcl-2 and Bcl-w, with a Ki of less than 1 nM .

HY-12011

HA14-1 2 Publications Verification	Bcl-2 Family	Cancer
HA14-1 is a *Bcl-2/Bcl-X_L* antagonist. HA14-1 binds the designated pocket on Bcl-2 with the IC₅₀ of ≈9 μM in competing with the Bcl-2 binding of Flu-BakBH3, and inhibits its function.

HY-156620

Lacutoclax LP-108	Bcl-2 Family	Cancer
Lacutoclax is a Bcl-2 inhibitor with antineoplastic activity .

HY-122047

SW063058	Autophagy	Cancer
SW063058 is an autophagy inducer that specifically disrupts the binding of Beclin 1 to Bcl-2 while leaving the interaction between Bcl-2 and pro-apoptotic members like Bax and BIM unaffected. By inhibiting the negative regulatory effects of Bcl-2 on Beclin 1, which is crucial for the initiation of autophagy, SW063058 promotes autophagic activity without triggering cytotoxicity, apoptosis, or other forms of cell death in vitro.

Cat. No.	Product Name

HY-L003

Apoptosis Compound Library

3,165 compounds

Apoptosis is an ordered and orchestrated cellular process that occurs in physiological and pathological conditions, which is also called programmed cell death (PCD). Apoptosis plays a crucial role in developing and maintaining the health of the body by eliminating old cells, unhealthy cells and unnecessary cells. Too little or too much apoptosis contribute to many diseases. When apoptosis does not work correctly, cells that should be eliminated may persist and become immortal, for example, in cancer and leukemia. When apoptosis works overly well, it kills too many cells and inflicts grave tissue damage. This is the case in strokes and neurodegenerative disorders such as Alzheimer's, Huntington's, and Parkinson's disease.

MCE designs a unique collection of 3,165 apoptosis-related compounds mainly focusing on the key targets in the apoptosis signaling pathway and can be used in the research of apoptosis signal pathway and related diseases.

Cat. No.	Product Name	Type

HY-W250111

Carboxymethyl chitosan

Biochemical Assay Reagents

Carboxymethyl chitosan is a derivative of chitosan. Carboxymethyl chitosan inhibits Apoptosis and ROS. Carboxymethyl chitosan increases the expression of Bcl-2 and reduces the expression of Bax, cytochrome c and caspase-3. Carboxymethyl chitosan inhibits the migration of various cells. Carboxymethyl chitosan exerts antitumor effects on Lewis tumors and hepatocarcinoma ^[2] .

HY-126437

Poly-L-lysine hydrobromide (MW 30000-70000)

1 Publications Verification

Drug Delivery

Poly-L-lysine hydrobromide (MW 30000-70000) is a water-soluble synthetic polypeptide. Poly-L-lysine hydrobromide (MW 30000-70000) downregulates Bcl-2 and upregulates Bax and p53 proteins. Poly-L-lysine hydrobromide (MW 30000-70000) promotes Apoptosis and reduces VEGF expression. Poly-L-lysine hydrobromide (MW 30000-70000) shows anticancer activity against a variety of tumors. Poly-L-lysine hydrobromide (MW 30000-70000) can also be used as a coating material ^[2] .

HY-W250122

Glutamic acid sodium salt

Monosodium glutamate

Biochemical Assay Reagents

Glutamic acid sodium salt (Monosodium glutamate) is an orally active food flavor enhancer. Glutamic acid sodium salt causes ROS generation, mitochondrial dysfunction, and Apoptosis. Glutamic acid sodium salt upregulates CHOP, Grp78, and Bcl-2. Glutamic acid sodium salt impairs cognition, induces depressive-like behavior, induces hyperalgesia, and induces obesity and insulin resistance. Glutamic acid sodium salt can be used to study neurotoxicity (e.g., brain damage, cognitive impairment), metabolic disorders (e.g., obesity, insulin resistance), hepatotoxicity, and renal toxicity, as well as pain-related disorders ^[2] .

Cat. No.	Product Name	Target	Research Area

HY-P2343

BH3 hydrochloride	Apoptosis	Cancer
BH3 hydrochloride, a BBB penetrated peptide, provoke apoptosis either by direct activation of pro-apoptotic Bax/Bak or by neutralizing anti-apoptotic Bcl-2 proteins (Bcl-2, Bcl-XL, Bcl-w, Mcl-1 and A-1) via their BH3 domian ^[2].

HY-P1527

Bim BH3 1 Publications Verification	Bcl-2 Family	Others
Bim BH3 is a biological active peptide. (This Bim peptide belongs to the pro-apoptotic Bcl-2 family of proteins.)

HY-P5325A

Bid BH3 (80-99) acetate	Bcl-2 Family	Others
Bid BH3 (80-99) (acetate) is a biological active peptide. (BID is a pro-apoptotic member of the 'BH3-only' (BOPS) subset of the BCL-2 family of proteins that constitute a critical control point in apoptosis. Bid is the first of the BOPs reported to bind and activate Bcl-2, Bax, and Bak. Bid serves as a death-inducing ligand that moves from the cytosol to the mitochondrial membrane to inactivate Bcl-2 or to activate Bax.Pyroglutamyl (pGlu) peptides may spontaneously form when either Glutamine (Q) or Glutamic acid (E) is located at the sequence N-terminus. The conversion of Q or E to pGlu is a natural occurrence and in general it is believed that the hydrophobic γ-lactam ring of pGlu may play a role in peptide stability against gastrointestinal proteases. Pyroglutamyl peptides are therefore considered a normal subset of such peptides and are included as part of the peptide purity during HPLC analysis.)

HY-P1889

Bim BH3, Peptide IV	Bcl-2 Family	Inflammation/Immunology
Bim BH3, Peptide IV is a 26-residue peptide from BH3-only protein Bim, which belongs to the pro-apoptotic group of the Bcl-2 family of proteins ^[2].

HY-P10057

cpm-1285	Apoptosis	Cancer
cpm-1285 induces apoptosis by functionally blocking intracellular Bcl-2 and related death antagonists. cpm-1285 shows strong binding potency to Bcl-2 with an IC₅₀ value of 130 nM. cpm-1285 reduces tumor burden in mice .

HY-P5327

r8 Bid BH3	Bcl-2 Family	Others
r8 Bid BH3 is a biological active peptide. (The Bid BH3 is a pro-apoptotic member of the 'BH3-only' subset of BCL-2 family proteins that constitute a critical control point in apoptosis. r8BIDBH3 is lethal to human leukemia cell lines that expresse Bcl-2. The Bcl-2 antagonists may have the potential to be efficacious in cancer therapy. Poly-D-arginine (d-isomer as denoted by rrrrrrrr) is fused to the Bid BH3 peptide to facilitate cellular uptake of the peptide.)

HY-P10058

cpm-1285m	Biochemical Assay Reagents	Cancer
cpm-1285m is a cell-permeable mutated peptide analogue of cpm-1285 (Bcl-2 inhibitory peptide). cpm-1285m contains a single substitution of alanine for Leu-151, and exhibits a decrease in *Bcl-2* binding affinity with a reduction in IC₅₀ of ∼15-fold. cpm-1285m can be used as a control of cpm-1285 .

HY-P5324

Bad BH3 (mouse)	Bcl-2 Family	Others
Bad BH3 (mouse) is a biological active peptide. (This is a bcl-2 binding peptide. This peptide is derived from the BH3 domain (a death domain) of Bad, amino acid residues 140 to 165.)

HY-P5325

Bid BH3 (80-99)	Bcl-2 Family	Others
Bid BH3 (80-99) is a biological active peptide. (BID is a pro-apoptotic member of the 'BH3-only' (BOPS) subset of the BCL-2 family of proteins that constitute a critical control point in apoptosis. Bid is the first of the BOPs reported to bind and activate Bcl-2, Bax, and Bak. Bid serves as a death-inducing ligand that moves from the cytosol to the mitochondrial membrane to inactivate Bcl-2 or to activate Bax.Pyroglutamyl (pGlu) peptides may spontaneously form when either Glutamine (Q) or Glutamic acid (E) is located at the sequence N-terminus. The conversion of Q or E to pGlu is a natural occurrence and in general it is believed that the hydrophobic γ-lactam ring of pGlu may play a role in peptide stability against gastrointestinal proteases. Pyroglutamyl peptides are therefore considered a normal subset of such peptides and are included as part of the peptide purity during HPLC analysis.)

HY-P1889A

Bim BH3, Peptide IV TFA	Bcl-2 Family	Inflammation/Immunology
Bim BH3, Peptide IV TFA is a 26-residue peptide from BH3-only protein Bim, which belongs to the pro-apoptotic group of the Bcl-2 family of proteins ^[2].

HY-P1733

BMf-BH3 BMF-Y	Apoptosis	Cancer
BMf-BH3 (BMF-Y) belongs to the Bcl-2 apoptosis mediator family. BH3-only protein, Bmf is a key molecule for histone deacetylase (HDAC) inhibitors mediated enhancing effect on ionizing radiation-induced cell death ^[2].

HY-P10336

Serpinin	Serpin	Neurological Disease Endocrinology
Serpinin is an agonist of the protease inhibitor Nexin-1 (PN-1). Serpinin upregulates the expression of PN-1 through the cAMP-PKA-Sp1 signaling pathway, promoting granule biogenesis in endocrine cells. Serpinin is used in research related to the regulation of secretory function . Serpinin is a selective agonist for β-adrenergic receptors. Serpinin interacts with β1-adrenergic receptors to activate the AC-cAMP-PKA pathway, which regulates myocardial systolic and diastolic function. pGlu-serpinin upregulates Bcl2 mRNA transcription and exerts neuroprotective effects ^[2].

HY-P10833

C-VGB3	VEGFR PI3K Akt mTOR ERK Apoptosis	Cardiovascular Disease Cancer
C-VGB3 is a selective vascular endothelial growth factor receptor 2 (VEGFR2) antagonist, which inhibits VEGFR2-mediated PI3K/AKT/mTOR and PLCγ/ERK1/2 signaling pathways. C-VGB3 binds to the extracellular domain of VEGFR2, blocking ligand-receptor interaction and inducing apoptosis in endothelial and tumor cells through both intrinsic (involving Bcl2 family and caspases) and extrinsic (death receptor-mediated) pathways. C-VGB3 is promising for research of angiogenesis-related cancers, such as breast cancer ^[2].

Cat. No.	Product Name	Target	Research Area

HY-P990344

*Anti-Bcl-2* Antibody**	Bcl-2 Family	Inflammation/Immunology
The Anti-Bcl-2 Antibody is a humanized antibody expressed in CHO cells, targeting *Bcl-2. The Anti-Bcl-2* Antibody has a huIgG1 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 145.74 kDa. The isotype control for Anti-Bcl-2 Antibody can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001).

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N1157

Thevetiaflavone Apigenin-5-methyl ether	Flavonoids other families Flavones Source classification Phenols Polyphenols Plants	Bcl-2 Family Caspase
Thevetiaflavone could upregulate the expression of *Bcl-2* and downregulate that of Bax and caspase-3.

HY-13407

Gossypol 5+ Cited Publications BL 193	Malvaceae Classification of Application Fields Source classification Phenols Polyphenols Gossypium herbaceum Linn. Plants Disease Research Fields Cancer	Bcl-2 Family
Gossypol binds to *Bcl-xL* protein and *Bcl-2* protein with K_is of 0.5-0.6 μM and 0.2-0.3 mM, respectively.

HY-N2897

Dihydrokaempferol 5 Publications Verification	Flavanonols Flavonoids Classification of Application Fields Leguminosae Source classification Phenols Polyphenols Bauhinia championii (Benth.) Benth. Plants Inflammation/Immunology Disease Research Fields	Apoptosis Bcl-2 Family
Dihydrokaempferol is isolated from Bauhinia championii (Benth). Dihydrokaempferol induces apoptosis and inhibits Bcl-2 and Bcl-xL expression. Dihydrokaempferol is a good candidate for new antiarthritic agents .

HY-17510

Gossypol (acetic acid) 5+ Cited Publications (±)-Gossypol-acetic acid; BL-193 (acetic acid)	other families Classification of Application Fields Source classification Phenols Polyphenols Plants Disease Research Fields Cancer	Bcl-2 Family
Gossypol acetic acid ((±)-Gossypol-acetic acid) binds to *Bcl-xL* protein and *Bcl-2* protein with K_is of 0.5-0.6 μM and 0.2-0.3 mM, respectively.

HY-119931

2-Hydroxychalcone	Chalcones Monophenols Flavonoids Classification of Application Fields Source classification Phenols Metabolic Disease Endogenous metabolite Disease Research Fields	Bcl-2 Family Apoptosis NF-κB Parasite
2-hydroxychalcone, a natural flavonoid, is a potent antioxidant, inhibiting lipid peroxidation. 2-Hydroxychalcone induces apoptosis by Bcl-2 downregulation. 2-Hydroxychalcone inhibits the activation of NF-kB ^[2] .

HY-149436

*CDK2/Bcl2-IN-1*	Terpenoids Zygophyllaceae Source classification Diterpenoids Plants Zygophyllum album L.f.	CDK
CDK2/Bcl2-IN-1 (compound 1), a saponin and a CDK-2 inhibitor (IC₅₀=117.6 nM) with promising cytotoxicity against cancer cells. CDK2/Bcl2-IN-1 also inhibits Bcl-2, and induces apoptosis in A549 lung cancer cells .

HY-N8579

Eugenyl benzoate	Microorganisms Simple Phenylpropanols Source classification Phenylpropanoids	Others
Eugenyl benzoate has the potency for scavenging of DPPH radical. Eugenyl Benzoate Derivatives can be used for development of *BCL-2* inhibitors ^[2].

HY-N1218

Stellasterol	Natural Products Animals Source classification	Glycosidase Bcl-2 Family
Stellasterol is a natural product. Stellasterol has high affinity towards *Bcl-2* protein (K_i: 118.05 nM). Stellasterol is a weak α-glucosidase inhibitor ^[2].

HY-N3828

epi-Eriocalyxin A	Other Terpenoids Lychnophora antillana Classification of Application Fields Terpenoids Labiatae Source classification Plants Disease Research Fields Cancer	Apoptosis ERK JNK
epi-Eriocalyxin A (Epieriocalyxin A), a diterpenoid isolated from Isodon eriocalyx, induces colon cancer apoptosis. epi-Eriocalyxin A also inhibits *ERK1/2* and JNK activation, which suppresses Bcl-2 expression .

HY-13407R

Gossypol (Standard) BL 193 (Standard)	Malvaceae Source classification Phenols Polyphenols Gossypium herbaceum Linn. Plants	Reference Standards Bcl-2 Family
Gossypol (Standard) is the analytical standard of Gossypol. This product is intended for research and analytical applications. Gossypol binds to Bcl-xL protein and Bcl-2 protein with Kis of 0.5-0.6 μM and 0.2-0.3 mM, respectively.

HY-15464

(R)-(-)-Gossypol 2 Publications Verification AT-101; R-(-)-gossypol acetic acid	Malvaceae Classification of Application Fields Gossypium Source classification Phenols Plants Disease Research Fields Cancer	Bcl-2 Family Autophagy
(R)-(-)-Gossypol (AT-101) is the levorotatory isomer of a natural product Gossypol. AT-101 is determined to bind to *Bcl-2, Mcl-1* and *Bcl-xL* proteins with K_is of 260±30 nM, 170±10 nM, and 480±40 nM, respectively.

HY-N2897R

Dihydrokaempferol (Standard)	Flavanonols Flavonoids Leguminosae Source classification Phenols Polyphenols Bauhinia championii (Benth.) Benth. Plants	Reference Standards Apoptosis Bcl-2 Family
Dihydrokaempferol (Standard) is the analytical standard of Dihydrokaempferol. This product is intended for research and analytical applications. Dihydrokaempferol is isolated from Bauhinia championii (Benth). Dihydrokaempferol induces apoptosis and inhibits Bcl-2 and Bcl-xL expression. Dihydrokaempferol is a good candidate for new antiarthritic agents .

HY-17510R

Gossypol (acetic acid) (Standard) (±)-Gossypol-acetic acid (Standard); BL-193 (acetic acid) (Standard)	other families Source classification Phenols Polyphenols Plants	Reference Standards Bcl-2 Family
Gossypol (acetic acid) (Standard) is the analytical standard of Gossypol (acetic acid). This product is intended for research and analytical applications. Gossypol acetic acid ((±)-Gossypol-acetic acid) binds to Bcl-xL protein and Bcl-2 protein with Kis of 0.5-0.6 μM and 0.2-0.3 mM, respectively.

HY-N2067

Vanillyl alcohol p-(Hydroxymethyl)guaiacol	Monophenols Microorganisms Gastrodia elata Bl. Classification of Application Fields Orchidaceae Source classification Other Diseases Phenols Plants Disease Research Fields	Reactive Oxygen Species (ROS) Bcl-2 Family
Vanillyl alcohol (p-(Hydroxymethyl)guaiacol) is an orally active phenolic alcohol. Vanillyl alcohol reduces ROS generation. suppresses Bax, increases *Bcl-2*. Vanillyl alcohol has anti-angiogenic, anti-inflammatory, anti-nociceptive and neuroprotective effects. Vanillyl alcohol is used as a flavoring agent in foods and beverages ^[2] .

HY-N15315

Triptriolide	Triterpenes Terpenoids Source classification Celastraceae Tripterygium wilfordii Hook. f. Plants	Apoptosis MAP3K NF-κB
Triptriolide inhibits Puromycin aminonucleoside PAN (HY-15695)-induced apoptosis in mouse podocytes through regulation of Bcl-2 family proteins and inhibition of Caspase-3. Triptriolide promotes the cell survival, protects and restores the podocyte function through activation of TAK1-NF-κB signaling pathway and upregulation of podocin .

HY-N2342

Procyanidin C1 5+ Cited Publications PCC1	Classification of Application Fields Source classification Rosaceae Crataegus pinnatifida Bge. Plants Flavonoids Functional Molecules Research of Health Products Phenols Polyphenols Biflavones Disease Research Fields Cancer	Apoptosis
Procyanidin C1 (PCC1), a natural polyphenol with oral activity, causes DNA damage, cell cycle arrest and induces apoptosis. Procyanidin C1 decreases the level of Bcl-2, but enhances BAX, caspase 3 and 9 expression in cancer cells. Procyanidin C1 shows senotherapeutic activity and increases lifespan in mice ^[2].

HY-N2741

Vitexin B-1	Monophenols Verbenaceae Source classification Phenols Plants Vitex negundo Linn.	Bcl-2 Family
Vitexin B-1 is an inhibitor of *Bcl-2* and the agonist of Caspase. Vitexin B-1 has cytotoxic effect and induces apoptosis in MCF-7, ZR-75-1, MDA-MB-231, and COC1 cells with IC₅₀s of 3.2, 2.1, 1.8 and 0.39 μM, respectively .

HY-N1414A

3′,6-Disinapoylsucrose 1 Publications Verification	Natural Products Polymer products Plants Brassicaceae Raphanus sativus Linn.	Bcl-2 Family Apoptosis
3′,6-Disinapoylsucrose is a type of oligosaccharide that's effective when taken orally, and it has antidepressant, anti-anxiety, and antioxidant properties. 3′,6-Disinapoylsucrose inhibits neuronal apoptosis by lowering the ratio of Bax to *Bcl-2* in hippocampal neurons, and it enhances cognitive function in APP/PS1 transgenic mice by activating the CREB/BDNF signaling pathway ^[2].

HY-N1930

(-)-Hinesol Hinesol	Natural Products Plants Compositae Erythrina sigmoidea Hua	Apoptosis
(-)-Hinesol (Hinesol) is a potent anticancer agent. (-)-Hinesol induces apoptosis and cell cycle arrest at G0/G1 phase. (-)-Hinesol downregulates MEK/ERK pathway and NF-κB pathway and mediates theexpression of cyclin D1, Bax and Bcl-2. (-)-Hinesol has the potential for the research of non–small cell lung cancer .

HY-N0068

Solasodine 4 Publications Verification Purapuridine; Solancarpidine; Solasodin	Infection Cardiovascular Disease Alkaloids Piperidine Alkaloids Neurological Disease Classification of Application Fields Source classification Solanum nigrum Linn. Solanaceae Plants Inflammation/Immunology Disease Research Fields	MDM-2/p53 Fungal E1/E2/E3 Enzyme Apoptosis
Solasodine (Purapuridine) is a steroidal alkaloid that occurs in plants of the Solanaceae family. Solasodine induces apoptosis by inhibiting the p53-MDM2 complex, p21Waf1/Cip1, and Bcl-2 proteins. Solasodine has neuroprotective, antifungal, hypotensive, anticancer, antiatherosclerotic, antiandrogenic and anti-inflammatory activities ^[2] .

HY-N6690

Destruxin B	Infection Microorganisms Classification of Application Fields Cyclopeptides Source classification Disease Research Fields	Bcl-2 Family Caspase Apoptosis
Destruxin B, isolated from entomopathogenic fungus Metarhizium anisopliae, is one of the cyclodepsipeptides with insecticidal and anticancer activities. Destruxin B induces apoptosis via a Bcl-2 Family-dependent mitochondrial pathway in human nonsmall cell lung cancer cells . Destruxin B significantly activates caspase-3 and reduces tumor cell proliferation through caspase-mediated apoptosis, not only in vitro but also in vivo ^[2].

HY-N2416

Taccalonolide A	Classification of Application Fields Source classification Plants Disease Research Fields Tacca chantrieri Andre Taccaceae Steroids Cancer	Microtubule/Tubulin Apoptosis
Taccalonolide A is a microtubule stabilizer, which is a steroid isolated from Tacca chantrieri, with cytotoxic and antimalarial activities ^[2]. Taccalonolide A causes G₂-M accumulation, Bcl-2 phosphorylation and initiation of apoptosis . Taccalonolide A is effective in vitro against cell lines that overexpress P-glycoprotein (Pgp) and multidrug resistance protein 7 (MRP7), with an IC₅₀ of 622 nM for SK-OV-3 cells .

HY-N0361

Dihydrocapsaicin 3 Publications Verification	Alkaloids Monophenols Capsicum annuum L. Classification of Application Fields Other Alkaloids Source classification Phenols Metabolic Disease Solanaceae Plants Disease Research Fields	TRP Channel Reactive Oxygen Species (ROS) Apoptosis Caspase Bcl-2 Family Akt PI3K
Dihydrocapsaicin, a capsaicin, is a potent and selective TRPV1 (transient receptor potential vanilloid channel 1) agonist. Dihydrocapsaicin reduces AIF, Bax, and Caspase-3 expressions, and increased *Bcl-2, Bcl-xL* and p-Akt levels. Dihydrocapsaicin enhances the hypothermia-induced neuroprotection following ischemic stroke via PI3K/Akt regulation in rat ^[2] .

HY-N0087

Gambogic Acid 5 Publications Verification Beta-Guttiferrin	Natural Products Classification of Application Fields Guttiferae Plants Garcinia hanburyi Hook. f. Disease Research Fields Cancer	Bcl-2 Family Autophagy
Gambogic Acid (Beta-Guttiferrin) is derived from the gamboges resin of the tree Garcinia hanburyi. Gambogic Acid (Beta-Guttiferrin) inhibits *Bcl-X_L, Bcl-2, Bcl-W, Bcl-B, Bfl-1* and Mcl-1 with IC₅₀s of 1.47 μM, 1.21 μM, 2.02 μM, 0.66 μM, 1.06 μM and 0.79 μM.

HY-N0867

13-Oxyingenol-13-dodecanoate	Classification of Application Fields Terpenoids Gramineae Source classification Other Diseases Diterpenoids Leptochloa chinensis (Linn.) Nees Plants Disease Research Fields	HIV ULK Bcl-2 Family
13-Oxyingenol-dodecanoate (13OD) is a tumor suppressor agent. 13-Oxyingenol-dodecanoate has anti-HIV-1 activity with EC₅₀ value of 33.7 nM .13-Oxyingenol-dodecanoate can induce the expression of ULK1 to effect mitochondrial dysfunction and cellular autophagy. 13-Oxyingenol-dodecanoate also increases the expression of BAX and suppresses the expression of *BCL-2* to effect apoptosis ^[2].

HY-N0674A

Dehydrocorydaline chloride 35+ Cited Publications 13-Methylpalmatine chloride	Infection Alkaloids other families Classification of Application Fields Source classification Plants Isoquinoline Alkaloids Disease Research Fields	Bcl-2 Family Caspase PARP p38 MAPK Parasite Autophagy
Dehydrocorydaline chloride (13-Methylpalmatine chloride) is an alkaloid that regulates protein expression of Bax, *Bcl-2; activates caspase-7, caspase-8, and inactivates PARP* . Dehydrocorydaline chloride elevates p38 MAPK activation. Anti-inflammatory and anti-cancer activities ^[2]. Dehydrocorydaline chloride shows strong anti-malarial effects (IC₅₀?=38 nM), and low cytotoxicity (cell viability?>?90%) using P. falciparum 3D7 strain .

HY-N2342R

Procyanidin C1 (Standard) PCC1 (Standard)	Flavonoids Source classification Rosaceae Phenols Polyphenols Crataegus pinnatifida Bge. Plants Biflavones	Reference Standards Apoptosis
Procyanidin C1 (Standard) is the analytical standard of Procyanidin C1. This product is intended for research and analytical applications. Procyanidin C1 (PCC1), a natural polyphenol with oral activity, causes DNA damage, cell cycle arrest and induces apoptosis. Procyanidin C1 decreases the level of Bcl-2, but enhances BAX, caspase 3 and 9 expression in cancer cells. Procyanidin C1 shows senotherapeutic activity and increases lifespan in mice ^[2].

HY-N2067R

Vanillyl alcohol (Standard) p-(Hydroxymethyl)guaiacol (Standard)	Monophenols Microorganisms Gastrodia elata Bl. Orchidaceae Source classification Phenols Plants	Reference Standards Reactive Oxygen Species (ROS) Bcl-2 Family
Vanillyl alcohol (Standard) is the analytical standard of Vanillyl alcohol (HY-N2067). This product is intended for research and analytical applications. Vanillyl alcohol (p-(Hydroxymethyl)guaiacol) is an orally active phenolic alcohol. Vanillyl alcohol reduces ROS generation. suppresses Bax, increases *Bcl-2*. Vanillyl alcohol has anti-angiogenic, anti-inflammatory, anti-nociceptive and neuroprotective effects. Vanillyl alcohol is used as a flavoring agent in foods and beverages ^[2] .

HY-N0674B

Dehydrocorydaline (hydroxyl) 35+ Cited Publications 13-Methylpalmatine (hydroxyl)	Alkaloids Corydalis yanhusuo W. T. Wang Source classification Plants Papaveraceae	Bcl-2 Family Caspase PARP p38 MAPK Parasite Autophagy
Dehydrocorydaline (13-Methylpalmatine) hydroxyl is an alkaloid that regulates protein expression of Bax, Bcl-2; activates caspase-7, caspase-8, and inactivates PARP. Dehydrocorydaline hydroxyl elevates p38 MAPK activation. Anti-inflammatory and anti-cancer activities. Dehydrocorydaline hydroxyl shows strong anti-malarial effects (IC50=38 nM), and low cytotoxicity (cell viability > 90%) using P. falciparum 3D7 strain.

HY-N15424

Himachalol	Cedrus deodara (Roxburgh) G. Don Pinaceae Terpenoids Sesquiterpenes Source classification Plants	Apoptosis Bcl-2 Family
Himachalol, a sesquiterpene, is an orally active antispasmodic and anticancer constituent found in the wood of Cedrus deodara. Himachalol has anti-proliferative activity against the melanoma cells, and induces apoptosis (decreases Bcl-2 level and increases Bax level). Himachalol has systemic hypotension and peripheral vasodilation effect. Himachalol inhibits Carbachol-induced spasm of the intestine. The LD₅₀ of Himachalol in mice is 265 mg/kg (p.o.) and 247 mg/kg (i.p.) ^[2].

HY-N0674

Dehydrocorydaline 35+ Cited Publications 13-Methylpalmatine	Infection Alkaloids Corydalis yanhusuo W. T. Wang Classification of Application Fields Source classification Plants Isoquinoline Alkaloids Disease Research Fields Papaveraceae	Bcl-2 Family Caspase PARP p38 MAPK Parasite Autophagy
Dehydrocorydaline (13-Methylpalmatine) is an alkaloid that regulates protein expression of Bax, *Bcl-2; activates caspase-7, caspase-8, and inactivates PARP* . Dehydrocorydaline elevates p38 MAPK activation. Anti-inflammatory and anti-cancer activities ^[2]. Dehydrocorydaline shows strong anti-malarial effects (IC₅₀=38 nM), and low cytotoxicity (cell viability > 90%) using P. falciparum 3D7 strain .

HY-119833

Rubone	Chalcones Flavonoids Leguminosae Source classification Plants Brachypterum robustum (Roxburgh ex Candolle) Dalzell & Gibson	MicroRNA
Rubone, a chalcone analog, is a modulator of miR-34a. Rubone upregulates miR-34a expression in a p53 dependent manner, downregulates the downstream target Bcl-2 and Cyclin D1 expression, and suppresses hepatocellular carcinoma (HCC) growth in vivo. Rubone enhances the anticancer effect of Paclitaxel (PTX; HY-B0015) in PTX-resistant prostate cancer cell lines by reversing the expression of miR-34a downstream targets ^[2] .

HY-N16483

Procyanidin B2-3'-O-gallate	Structural Classification Source classification Vitis vinifera cv. Zalema Phenols Polyphenols Plants Vitaceae	Apoptosis Caspase Bcl-2 Family PARP Androgen Receptor
Procyanidin B2-3'-O-gallate is a mono-gallate ester that can be isolated from grape seed extract. Procyanidin B2-3'-O-gallate has anti-cancer efficacy and reduces the viability of prostate carcinoma LNCaP cells. Furthermore, Procyanidin B2-3'-O-gallate induces apoptosis, and causes caspases-9 and -3 and PARP cleavage, and down-regulates *Bcl-2, Bcl-Xl* and androgen receptor levels .

HY-N4238

Dehydrocorydaline nitrate 35+ Cited Publications 13-Methylpalmatine nitrate	Infection Alkaloids other families Classification of Application Fields Source classification Plants Isoquinoline Alkaloids Disease Research Fields	Bcl-2 Family Caspase PARP p38 MAPK Parasite Autophagy
Dehydrocorydaline nitrate (13-Methylpalmatine nitrate) is an alkaloid. Dehydrocorydaline regulates protein expression of Bax, *Bcl-2; activates caspase-7, caspase-8, and inactivates PARP* . Dehydrocorydaline nitrate elevates p38 MAPK activation. Anti-inflammatory and anti-cancer activities. ^[2]. Dehydrocorydaline nitrate shows strong anti-malarial effects (IC₅₀ =38 nM), and low cytotoxicity (cell viability > 90%) using P. falciparum 3D7 strain .

HY-N0361R

Dihydrocapsaicin (Standard)	Alkaloids Monophenols Capsicum annuum L. Other Alkaloids Source classification Phenols Solanaceae Plants	Reference Standards TRP Channel Reactive Oxygen Species (ROS) Apoptosis Caspase Bcl-2 Family Akt PI3K
Dihydrocapsaicin (Standard) is the analytical standard of Dihydrocapsaicin. This product is intended for research and analytical applications. Dihydrocapsaicin, a capsaicin, is a potent and selective TRPV1 (transient receptor potential vanilloid channel 1) agonist. Dihydrocapsaicin reduces AIF, Bax, and Caspase-3 expressions, and increased Bcl-2, Bcl-xL and p-Akt levels. Dihydrocapsaicin enhances the hypothermia-induced neuroprotection following ischemic stroke via PI3K/Akt regulation in rat ^[2] .

HY-N0087R

Gambogic Acid (Standard) Beta-Guttiferrin (Standard)	Natural Products Guttiferae Plants Garcinia hanburyi Hook. f.	Reference Standards Bcl-2 Family Autophagy
Gambogic Acid (Standard) is the analytical standard of Gambogic Acid. This product is intended for research and analytical applications. Gambogic Acid (Beta-Guttiferrin) is derived from the gamboges resin of the tree Garcinia hanburyi. Gambogic Acid (Beta-Guttiferrin) inhibits Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1 with IC₅₀s of 1.47 μM, 1.21 μM, 2.02 μM, 0.66 μM, 1.06 μM and 0.79 μM.

HY-N0168

Hesperetin 20+ Cited Publications	Flavonoids other families Neurological Disease Classification of Application Fields Sunscreen Flavonones Source classification Cosmetic Research Plants Disease Research Fields Cancer	p38 MAPK Autophagy Apoptosis Reactive Oxygen Species (ROS) NF-κB Bcl-2 Family
Hesperetin is a natural flavanone that can be found in citrus, and acts as a potent and orally active broad-spectrum inhibitor against human UGT activity. Hesperetin induces apoptosis via p38 MAPK activation. Hesperetin displays a range of bioactivities including antioxidant, anti-inflammatory, and anti-cancer. Hesperetin is found to induce cell-cycle arrest at G2/M phase. Hesperetin can reduce *Bcl-2* and enhance BaxM. Hesperetin induces apoptosis through inhibiting NF-κB receptor ^[2] .

HY-N3405

Lariciresinol 1 Publications Verification	Human Gut Microbiota Metabolites Source classification Lignans Arabidopsis thaliana Phenylpropanoids Plants Brassicaceae Endogenous metabolite	Glycosidase Bcl-2 Family Apoptosis TGF-β Receptor NF-κB Fungal
Lariciresinol is an orally active ingredient. Lariciresinol can be isolated from Arabidopsis thaliana. Lariciresinol inhibits α-glucosidase activity (IC₅₀ of 6.97 μM; K_i of 0.046 μM). Lariciresinol dereases *Bcl-2, upregulates Bax* and induces Apoptosis. Lariciresinol regulates TGF-β and NF-κB pathways. Lariciresinol has antitumor activity against liver cancer, gastric cancer, and breast cancer. Lariciresinol shows antifungal activity and anti-diabetic activity ^[2] .

HY-N0168A

(Rac)-Hesperetin	Flavonoids other families Flavonones Source classification Phenols Polyphenols Plants	p38 MAPK Apoptosis Autophagy Reactive Oxygen Species (ROS) NF-κB Bcl-2 Family
(Rac)-Hesperetin is the racemate of Hesperetin. Hesperetin is a natural flavanone that can be found in citrus, and acts as a potent and orally active broad-spectrum inhibitor against human UGT activity. Hesperetin induces apoptosis via p38 MAPK activation. Hesperetin displays a range of bioactivities including antioxidant, anti-inflammatory, and anti-cancer. Hesperetin is found to induce cell-cycle arrest at G2/M phase. Hesperetin can reduce *Bcl-2* and enhance BaxM. Hesperetin induces apoptosis through inhibiting NF-κB receptor ^[2] .

HY-N0292

Oleuropein 5 Publications Verification	Cardiovascular Disease Classification of Application Fields Anti-aging Source classification Plants Burseraceae Iridoids Canarium album (Lour.) Rauesch. Terpenoids Phenols Polyphenols Inflammation/Immunology Disease Research Fields Cancer	Cytochrome P450 PPAR Apoptosis
Oleuropein, found in olive leaves and oil, exerts antioxidant, anti-inflammatory and anti-atherogenic effects through direct inhibition of PPARγ transcriptional activity . Oleuropein induces apoptosis in breast cancer cells via the p53-dependent pathway and through the regulation of Bax and Bcl2 genes. Oleuropein also inhibits aromatase ^[2].

HY-126477

NNK 2 Publications Verification	Alkaloids Classification of Application Fields Source classification Pyridine Alkaloids Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite
NNK is a nicotine-nitrosated derivative. NNK simultaneously stimulates *Bcl2* phosphorylation exclusively at Ser ⁷⁰ and c-Myc at Thr ⁵⁸ and Ser ⁶² through activation of both *ERK1/2* and PKCα . NNK induces survival and proliferation of human lung cancer cells. NNK can be used for lung cancer mice model structure ^[2].

HY-N2132

Flavokawain B 2 Publications Verification Flavokavain B	Chalcones Monophenols Flavonoids other families Classification of Application Fields Source classification Phenols Plants Disease Research Fields Cancer	Apoptosis Caspase PARP Bcl-2 Family NF-κB PI3K Akt p38 MAPK MMP Reactive Oxygen Species (ROS)
Flavokawain B (Flavokavain B) is an orally active chalcone. Flavokawain B results in activation of caspase-9, -3 and -8, cleavage of PARP. Flavokawain B down-regulates *Bcl-2* with concomitant increase in Bax level. Flavokawain B inhibits NF-κB, PI3K/Akt and MAPK signaling pathway. Flavokawain B exhibits Apoptotic effects. Flavokawain B inhibits MMP-9 and promotes ROS generation. Flavokawain B inhibits multiple tumors and inflammation ^[2] .

HY-N6576

Hellebrigenin	Animals Classification of Application Fields Source classification Disease Research Fields Steroids Cancer	p38 MAPK ERK JNK IAP PARP Apoptosis Caspase
Hellebrigenin is an inhibitor that selectively targets the MAPK signaling pathway (ERK, p38, JNK) and XIAP, and can inhibit Akt expression and phosphorylation. Hellebrigenin can activate endogenous apoptosis pathways (such as mitochondrial membrane potential disruption, Caspase family activation, PARP cleavage), downregulate anti-apoptotic proteins (Bcl-2, *Bcl-xL) and upregulate pro-apoptotic proteins (Bax, Bak). Hellebrigenin can also induce DNA double-strand breaks to activate the ATM* pathway. Hellebrigenin can inhibit tumor cell proliferation and clone formation, and is mainly used in the study of oral squamous cell carcinoma, liver cancer and other cancers ^[2].

HY-N0763

Angelicin 5+ Cited Publications Isopsoralen	Classification of Application Fields Leguminosae Source classification Coumarins Phenylpropanoids Psoralea corylifolia L. Plants Disease Research Fields Cancer	Apoptosis Virus Protease NF-κB p38 MAPK JNK Caspase
Angelicin is a furanocoumarin compound that functions as an inhibitor of NF-κB and MAPK signaling pathways, exhibiting anti-inflammatory, antiviral, and antitumor activities. It suppresses the lytic replication of γ-herpesviruses, such as MHV-68, early during viral infection, potentially inhibiting RTA gene expression (IC₅₀=28.95 μM). Angelicin also mitigates inflammation by inhibiting the phosphorylation and nuclear translocation of NF-κB, and the phosphorylation of p38 and JNK. Furthermore, it induces apoptosis in neuroblastoma cells by downregulating anti-apoptotic proteins like *Bcl-2, Bcl-xL, and Mcl-1, while activating caspase-9* and caspase-3.

HY-N3584

Paris saponin VII 4 Publications Verification Chonglou Saponin VII	Liliaceae Classification of Application Fields Source classification Trillium tschonoskii Maxim. Plants Disease Research Fields Steroids Cancer	Akt p38 MAPK P-glycoprotein Bcl-2 Family Caspase PARP Autophagy Apoptosis
Paris saponin VII (Chonglou Saponin VII) is a steroidal saponin isolated from the roots and rhizomes of Trillium tschonoskii. Paris saponin VII-induced apoptosis in K562/ADR cells is associated with Akt/MAPK and the inhibition of P-gp. Paris saponin VII attenuates mitochondrial membrane potential, increases the expression of apoptosis-related proteins, such as Bax and cytochrome c, and decreases the protein expression levels of Bcl-2, caspase-9, caspase-3, PARP-1, and p-Akt. Paris saponin VII induces a robust autophagy in K562/ADR cells and provides a biochemical basis in the treatment of leukemia .

HY-107738

Guggulsterone 15+ Cited Publications Z/E-Guggulsterone	Triterpenes Classification of Application Fields Terpenoids Plants Burseraceae Disease Research Fields Commiphora wightii Cancer	Apoptosis JNK Akt Caspase FXR Autophagy
Guggulsterone is a plant sterol derived from the gum resin of the tree Commiphora wightii. Guggulsterone inhibits the growth of a wide variety of tumor cells and induces apoptosis through down regulation of antiapoptotic gene products (*IAP1, xIAP, Bfl-1/A1, Bcl-2, cFLIP and survivin), modulation of cell cycle proteins (cyclin D1 and c-Myc), activation of caspases and JNK, inhibition of Akt* ^[2]. Guggulsterone, a farnesoid X receptor (FXR) antagonist, with IC₅₀s of 24.06 μM and 39.05 μM for (-)-(E)-Guggulsterone (HY-N7781) and (Z)-Guggulsterone (HY-110066), respectively .

HY-N0168AR

(Rac)-Hesperetin (Standard)	Flavonoids other families Flavonones Source classification Phenols Polyphenols Plants	Reference Standards p38 MAPK Apoptosis Autophagy Reactive Oxygen Species (ROS) Bcl-2 Family NF-κB
(Rac)-Hesperetin (Standard) is the analytical standard of (Rac)-Hesperetin. This product is intended for research and analytical applications. (Rac)-Hesperetin is the racemate of Hesperetin. Hesperetin is a natural flavanone that can be found in citrus, and acts as a potent and orally active broad-spectrum inhibitor against human UGT activity. Hesperetin induces apoptosis via p38 MAPK activation. Hesperetin displays a range of bioactivities including antioxidant, anti-inflammatory, and anti-cancer. Hesperetin is found to induce cell-cycle arrest at G2/M phase. Hesperetin can reduce *Bcl-2* and enhance BaxM. Hesperetin induces apoptosis through inhibiting NF-κB receptor ^[2] .

HY-N0292R

Oleuropein (Standard)	Iridoids Canarium album (Lour.) Rauesch. Terpenoids Source classification Phenols Polyphenols Plants Burseraceae	Cytochrome P450 Reference Standards PPAR Apoptosis
Oleuropein (Standard) is the analytical standard of Oleuropein. This product is intended for research and analytical applications. Oleuropein, found in olive leaves and oil, exerts antioxidant, anti-inflammatory and anti-atherogenic effects through direct inhibition of PPARγ transcriptional activity . Oleuropein induces apoptosis in breast cancer cells via the p53-dependent pathway and through the regulation of Bax and Bcl2 genes. Oleuropein also inhibits aromatase ^[2].

HY-126477R

NNK (Standard)	Alkaloids Source classification Pyridine Alkaloids Endogenous metabolite	Reference Standards Endogenous Metabolite
NNK (Standard) is the analytical standard of NNK. This product is intended for research and analytical applications. NNK is a nicotine-nitrosated derivative. NNK simultaneously stimulates Bcl2 phosphorylation exclusively at Ser70 and c-Myc at Thr58 and Ser62 through activation of both ERK1/2 and PKCα . NNK induces survival and proliferation of human lung cancer cells. NNK can be used for lung cancer mice model structure ^[2].

HY-107738R

Guggulsterone (Standard)	Triterpenes Terpenoids Plants Burseraceae Commiphora wightii	Apoptosis JNK Akt Caspase FXR Autophagy Reference Standards
Guggulsterone (Standard) is the analytical standard of Guggulsterone (HY-107738). This product is intended for research and analytical applications. Guggulsterone is a plant sterol derived from the gum resin of the tree Commiphora wightii. Guggulsterone inhibits the growth of a wide variety of tumor cells and induces apoptosis through down regulation of antiapoptotic gene products (*IAP1, xIAP, Bfl-1/A1, Bcl-2, cFLIP and survivin), modulation of cell cycle proteins (cyclin D1 and c-Myc), activation of caspases and JNK, inhibition of Akt. Guggulsterone, a farnesoid X receptor (FXR)* antagonist, with IC₅₀s of 24.06 μM and 39.05 μM for (-)-(E)-Guggulsterone (HY-N7781) and (Z)-Guggulsterone (HY-110066), respectively.

Species:	Human (14) Mouse (4)
Tag:	His (15) Tag Free (2) Myc (1) GST (1)
Source:	E. coli Cell-free (1) P. pastoris (1) E. coli (16)

Cat. No.	Compare	Product Name	Species	Source

HY-P72101

	BCL2 Protein, Mouse (His) 1 Publications Verification Bcl2; Bcl-2; Apoptosis regulator Bcl-2	Mouse	E. coli
	BCL2 protein crucially regulates cell death by controlling mitochondrial membrane permeability. It interacts with caspases in a feedback loop, inhibiting their activity. BCL2 prevents cytochrome c release from mitochondria and binds to apoptosis-activating factor (APAF-1). BCL2 Protein, Mouse (His) is the recombinant mouse-derived BCL2 protein, expressed by E. coli , with N-6*His labeled tag.

HY-P7537

	BCL2 Protein, Human (His) rHuApoptosis Regulator Bcl-2, His; B-cell Lymphoma 2; Apoptosis Regulator Bcl-2	Human	E. coli
	BCL2 Protein regulates the mitochondrial membrane permeability, and inhibits the caspase activity, thereby suppressing the apoptosis in various cell types. BCL2 Protein interacts with BECN1 and AMBRA1, and inhibits the autophagy. BCL2 Protein, Human (His) is the human-derived resombinant BCL2 Protein that is expressed in in E. coli with a His tag at the C-terminus.

HY-P75590

	BCL2A1 Protein, Human (His) Bcl-2-related protein A1; Protein BFL-1; BCL2L5; BFL1; GRS; HBPA1	Human	E. coli
	The BCL2A1 protein plays a critical role in resisting apoptosis triggered by IL-3 deprivation, suggesting its importance in the response of hematopoietic cells to external signals and may be involved in protecting endothelial cell survival during infection. It also inhibits serum starvation-induced apoptosis in mammary epithelial cells (HC11). BCL2A1 Protein, Human (His) is the recombinant human-derived BCL2A1 protein, expressed by E. coli , with N-His labeled tag.

HY-P7650

	Bcl-2-like protein 1 Protein, Human (His) rHuBcl-2-like protein 1, His; Bcl-2-Like Protein 1; Apoptosis Regulator Bcl-X; BCL2L;	Human	E. coli
	Bcl-2-like protein 1 Protein, Human (His) is an important apoptosis regulating gene that codes for both an anti-apoptotic (Bcl-x_L) and a pro-apoptotic (Bcl-x_S) splice variant.

HY-P7653

	Bcl-2-like protein 2 Protein, Human (His) rHuBcl-2-like protein 2, His; Bcl-2-Like Protein 2; Apoptosis Regulator Bcl-W; BCL2L2; KIAA0271	Human	E. coli
	Bcl-2-like protein 2 is a key regulator that promotes cell survival and prevents dexamethasone-induced apoptosis, which is critical for postmitotic Sertoli cells. It inhibits BAX, emphasizing its role in survival mechanisms. Bcl-2-like protein 2 Protein, Human (His) is the recombinant human-derived Bcl-2-like protein 2 protein, expressed by E. coli , with C-6*His labeled tag.

HY-P72846

	Bcl-XL Protein, Mouse (His) Bcl-2-like protein 1; Bcl2-L-1; Apoptosis regulator Bcl-X; Bclx	Mouse	E. coli
	Bcl-XL protein forms heterodimers with BAX, BAK, or BCL2, but its antiapoptotic activity does not require heterodimerization with BAX. Bcl-XL Protein, Mouse (His) is the recombinant mouse-derived Bcl-XL protein, expressed by E. coli , with C-His labeled tag.

HY-P72846A

	Bcl-XL Protein, Mouse (C-His) Bcl-2-like protein 1; Bcl2-L-1; Apoptosis regulator Bcl-X; Bclx	Mouse	E. coli
	Bcl-XL protein forms heterodimers with BAX, BAK, or BCL2, but its antiapoptotic activity does not require heterodimerization with BAX. Bcl-XL Protein, Mouse (C-His) is the recombinant mouse-derived Bcl-XL, expressed by E. coli , with C-6*His labeled tag.

HY-P7651

	Bax Protein, Human (His) rHuBCL2L4, His; Apoptosis Regulator BAX; Bcl-2-Like Protein 4; BCL2L4; BAX	Human	E. coli
	Bax Protein, Human (His) suppresses tumorigenesis and stimulates apoptosis. BCL2L4 (BAX) is the proapoptotic members of the Bcl-2 family that are ubiquitously expressed in different tissues.

HY-P76165

	BCL2L12 Protein, Human (GST) Bcl-2-like protein 12; Bcl2-L-12; Bcl-2-related proline-rich protein; BPR	Human	E. coli
	BCL2-like 12 (BCL2L12) is a new member of the apoptosis-related BCL2 gene family. BCL2L12 contains a highly conserved BH2 domain, a BH3-like domain and a proline-rich region. BCL2L12 exhibits pro-apoptotic activity in breast tumor and gastric cancer. BCL2L12 is an inhibitor of post-mitochondrial effector caspase activation, as it binds to and inhibits caspase-7 and upregulates the caspase-3-specific inhibitor 伪B-crystallin (CRYAB). BCL2L12 attenuates endogenous p53-directed transcriptomic changes after genotoxic stress and inhibits p53-dependent DNA damage-induced apoptosis. BCL2L12 Protein, Human (GST) is the recombinant human-derived BCL2L12 protein, expressed by E. coli , with N-GST labeled tag.

HY-P75473

	BMF Protein, Human (His) Bcl-2-modifying factor; BMF	Human	E. coli
	BMF proteins may play a key role in apoptosis, with isoform 1 being the major promoter. It interacts with anti-apoptotic proteins (including MCL1, BCL2, BCL2L1/BCL-Xl, BCL2A1 and BCL2L2/BCL-w), suggesting involvement in the regulatory network of cell death. BMF Protein, Human (His) is the recombinant human-derived BMF protein, expressed by E. coli , with N-His labeled tag.

HY-P700303

	Bcl-2-like Protein 11 Protein, Human (His) rHuBcl-2-like Protein 11, His; Bcl-2-like protein 11; BIML	Human	E. coli
	Bcl-2-like protein 11 (BCL2L11), despite its classification, does not interact with humanin. This unique feature distinguishes BCL2L11 from expected protein-protein interactions typically associated with Bcl-2 family members. Bcl-2-like Protein 11 Protein, Human (His) is the recombinant human-derived Bcl-2-like Protein 11 protein, expressed by E. coli , with N-6*His labeled tag.

HY-P702614

	Bax Protein, Human (Cell-Free, His) rHuBCL2L4, His; Apoptosis Regulator BAX; Bcl-2-Like Protein 4; BCL2L4; BAX	Human	E. coli Cell-free
	Bax Protein, Human (Cell-Free, His) is the recombinant human-derived Bax, expressed by E. coli Cell-free, with N-10*His labeled tag.

HY-P702954

	BAD Protein, Human (His, Myc) BBC6; BCL2L8	Human	E. coli
	BAD Protein, Human (His, Myc) is the recombinant human-derived BAD, expressed by E.coli, with His, Myc labeled tag.

HY-P703089

	BAK1 Protein, Human BAK; BCL2L7; CDN1	Human	E. coli
	BAK1 Protein, Human is the recombinant human-derived BAK1, expressed by E. coli, with tag free labeled tag.

HY-P71848

	BAG-3 Protein, Mouse (P.pastoris, His) Bag3; Bis; MNCb-2243BAG family molecular chaperone regulator 3; BAG-3; Bcl-2-associated athanogene 3; Bcl-2-binding protein Bis	Mouse	P. pastoris
	The BAG-3 protein is a co-chaperone of HSP70 and HSC70, acting as a nucleotide exchange factor to promote the release of ADP from these partners, thus triggering substrate release. BAG-3 Protein, Mouse (P.pastoris, His) is the recombinant mouse-derived BAG-3 protein, expressed by P. pastoris , with N-His labeled tag.

HY-P7647

	BAG-2 Protein, Human (His) rHuBAG2, His; BAG Family Molecular Chaperone Regulator 2; BAG-2; Bcl-2-Associated Athanogene 2; BAG2	Human	E. coli
	BAG2 Protein, Human (His) promotes tumorigenesis through enhancing mutant p53 protein levels and function. BAG2 is a target of the c-Myc gene and is involved in cellular senescence via the p21CIP1 pathway.

HY-P7670

	BNIP3/NIP3 Protein, Human (His) rHuBNIP3, His; BNIP3; NIP3; BCL2/Adenovirus E1B 19 kDa Protein-Interacting Protein 3	Human	E. coli
	BNIP3/NIP3 Protein, Human (His) expresses in E. coliwith a His tag. BNIP3 belongs to the Bcl-2 protein family that regulates programmed cell death.

HY-P75471

	BNIP3L Protein, Human BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like; NIP3L; BNIP3L; BNIP3A; BNIP3H; NIX	Human	E. coli
	BNIP3L, a pro-apoptotic member of the Bcl-2 family, possesses a BH3 domain and binds to Bcl-2. It directly targets mitochondria, inducing apoptotic changes like membrane potential loss and cytochrome c release. With ubiquitous expression, especially in fat and ovary, the gene suggests involvement in diverse physiological processes across multiple organs, emphasizing its potential significance. BNIP3L Protein, Human is the recombinant human-derived BNIP3L protein, expressed by E. coli , with tag free.

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Cat. No.	Product Name	Chemical Structure

HY-10087S

Navitoclax-d8 1 Publications Verification
Navitoclax-d₈ is the deuterium labeled Navitoclax. Navitoclax (ABT-263) is a potent and orally active Bcl-2 family protein inhibitor that binds to multiple anti-apoptotic Bcl-2 family proteins, such as Bcl-xL, Bcl-2 and Bcl-w, with a Ki of less than 1 nM .

HY-15531S

Venetoclax-d8
Venetoclax-d₈ is deuterium labeled Venetoclax. Venetoclax (ABT-199; GDC-0199) is a highly potent, selective and orally bioavailable Bcl-2 inhibitor with a K_i of less than 0.01 nM. Venetoclax induces autophagy ^[2] .

HY-50907S

ABT-737-d8

ABT 737-d₈ is the deuterium labeled ABT-737. ABT-737, a BH3 mimetic, is a potent Bcl-2, Bcl-x_L and Bcl-w inhibitor with EC₅₀s of 30.3 nM, 78.7 nM, and 197.8 nM, respectively. ABT-737 induces the disruption of the BCL-2/BAX complex and BAK-dependent but BIM-independent activation of the intrinsic apoptotic pathway. ABT-737 induces autophagy and has the potential for acute myeloid leukemia (AML) research ^[2] .

HY-N0361S

Dihydrocapsaicin-d3

Dihydrocapsaicin-d₃ is the deuterium labeled Dihydrocapsaicin (HY-N0361) . Dihydrocapsaicin, a capsaicin, is a potent and selective TRPV1 (transient receptor potential vanilloid channel 1) agonist. Dihydrocapsaicin reduces AIF, Bax, and Caspase-3 expressions, and increased Bcl-2, Bcl-xL and p-Akt levels. Dihydrocapsaicin enhances the hypothermia-induced neuroprotection following ischemic stroke via PI3K/Akt regulation in rat ^[2] .

HY-B0011S

Docetaxel-d9
Docetaxel-d₉ is the deuterium labeled Docetaxel. Docetaxel (RP-56976) is a microtubule?depolymerization inhibitor, with an IC₅₀ of 0.2 μM. Docetaxel attenuates the effects of?bcl-2 and bcl-xL gene expression. Docetaxel arrests the cell cycle at G2/M and leads to cell apoptosis. Docetaxel has anti-cancer activity .

HY-15531S1

Venetoclax-d6
Venetoclax-d₆ (ABT-199-d₆) is deuterium labeled Venetoclax. Venetoclax (ABT-199; GDC-0199) is a highly potent, selective and orally bioavailable *Bcl-2* inhibitor with a K_i of less than 0.01 nM. Venetoclax induces autophagy ^[2] .

HY-18628S

UMI-77-d4
UMI-77-d₄ is the deuterium labeled UMI-77. UMI-77 is a selective Mcl-1 inhibitor, which shows high binding affinity to Mcl-1 (IC50=0.31 μM). UMI-77 binds to the BH3 binding groove of Mcl-1 with Ki of 490 nM, showing selectivity over other members of anti-apoptotic Bcl-2 members.

HY-W713297

Moroxydine hydrochloride-d8

Moroxydine hydrochloride-d₈ (ABOB hydrochloride-d₈) is the deuterium labeled Moroxydine (ABOB) hydrochloride (HY-B0420A). Moroxydine hydrochloride is a broad-spectrum agent with multi-antiviral activities against DNA and RNA viruses, including influenza virus, herpes simplex, varicella zoster, measles, mumps disease, hepatitis C virus, etc. Moroxydine hydrochloride exhibits excellent antiviral activity and shows low cytotoxicity to cells infected by dsRNA viruses (grass carp reovirus, GCRV) and large DNA viruses (giant salamander iridovirus, GSIV). Moroxydine hydrochloride blocks the GCRV-induced cytopathic effects and eliminates nucleocapsids in ctenopharyngodon idella kidney (CIK) cells to keep the normal morphological structure. Moroxydine hydrochloride significantly inhibits the apoptosis, the caspase 3 activity, Bax expression and down-regulates Bcl-2 levels ^[1][2][3].

HY-B0011AS

Docetaxel-d5 trihydrate

Docetaxel-d₅ (trihydrate) is the deuterium labeled Docetaxel (Trihydrate). Docetaxel Trihydrate (RP-56976 Trihydrate) is an antineoplastic agent and inhibits microtubule?depolymerization with an IC₅₀ value of 0.2 μM . Docetaxel Trihydrate is a semisynthetic analog of taxol and attenuates the effects of?bcl-2?and?bcl-xL?gene expression. Docetaxel Trihydrate arrests the cell cycle at G2/M and leads to cell apoptosis .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P80565

	Bcl-2 Antibody (YA824) BCL2; Apoptosis regulator Bcl-2	WB	Human, Rat, Mouse
	Bcl-2 Antibody (YA824) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Bcl-2.

HY-P80566

	Bcl-2 Antibody (YA590) Maximum Cited Publications 6 Publications Verification BCL2; Apoptosis regulator Bcl-2	WB, IHC-P	Human, Mouse
	Bcl-2 Antibody (YA590) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Bcl-2.

HY-P86421

	Bcl-2 Antibody (YA6113) BCL2; Apoptosis regulator Bcl-2	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	Bcl-2 Antibody (YA6113) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Bcl-2.

HY-P80029

	Bcl-2 Antibody (YA589) 4 Publications Verification	WB, ICC/IF, IHC-P, FC	Human, Mouse, Rat
	Bcl-2 Antibody (YA589) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Bcl-2.

HY-P83740

	Bcl-2 Antibody (YA3469) BCL2; Apoptosis regulator Bcl-2	WB, IHC-P, IHC-F, ICC/IF	Human, Chicken
	Bcl-2 Antibody (YA3469) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Bcl-2.

HY-P85653

	Bcl-2 Antibody (YA5345) BCL2; Apoptosis regulator Bcl-2	WB, ICC/IF, ELISA	Human, Mouse, Rat
	Bcl-2 Antibody (YA5345) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to Bcl-2.

HY-P86688

	Bcl-2 Antibody (YA6380) Apoptosis regulator Bcl 2; Apoptosis regulator Bcl2; AW986256; B cell CLL/lymphoma 2; B cell leukemia/lymphoma 2; B cell lymphoma 2; Bcl 2; Bcl-2; Bcl2; BCL2 protein; C430015F12Rik; D630044D05Rik; D830018M01Rik; Leukemia/lymphoma, B-cell, 2; Oncogene B-cell leukemia 2; BCL2_HUMAN.	WB, IHC-P, IHC-F, IF-Tissue	Human
	Bcl-2 Antibody (YA6380) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Bcl-2.

HY-P86712

	Bcl-2 Antibody (YA6404) Apoptosis regulator Bcl 2; Apoptosis regulator Bcl2; AW986256; B cell CLL/lymphoma 2; B cell leukemia/lymphoma 2; B cell lymphoma 2; Bcl 2; Bcl-2; Bcl2; BCL2 protein; C430015F12Rik; D630044D05Rik; D830018M01Rik; Leukemia/lymphoma, B-cell, 2; Oncogene B-cell leukemia 2; BCL2_HUMAN.	WB, ICC/IF, FC	Human
	Bcl-2 Antibody (YA6404) is a Mouse-derived and non-conjugated IgG monoclonal antibody, targeting to Bcl-2.

HY-P82995

	Bcl2 L14 Antibody (YA2740) BCLG	WB, ICC/IF, IP	Human, Mouse, Rat
	Bcl2 L14 Antibody (YA2740) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Bcl2 L14.

HY-P82691

	BMF Antibody (YA2436) Bcl2 modifying factor; Bmf	WB, FC	Human, Mouse, Rat
	BMF Antibody (YA2436) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to BMF.

HY-P82648

	BPR Antibody (YA2393) BCL2 like 12; BCL2L12; BPR	WB, IHC-P, ICC/IF, IP, FC	Human
	BPR Antibody (YA2393) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to BPR.

HY-P85607

	BAG1 Antibody (YA5299) Bag 1; BAG family molecular chaperone regulator 1; BAG-1; BAG1; BAG1_HUMAN; BCL 2 Associated Athanogene 1; BCL 2 associated athanogene; BCL 2 binding athanogene 1; Bcl-2-associated athanogene 1; BCL2 associated athanogene 1; BCL2 associated athanogene; Glucocorticoid receptor-associated protein RAP46; HAP1; Haptoglobin; RAP 46; RAP46.	WB	Human, Mouse
	BAG1 Antibody (YA5299) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to BAG1.

HY-P86533

	Bad Antibody (YA6225) BAD; BBC6; BCL2L8; Bcl2 antagonist of cell death; BAD; Bcl-2-binding component 6; Bcl-2-like protein 8; Bcl2-L-8; Bcl-XL/Bcl-2-associated death promoter	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	Bad Antibody (YA6225) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Bad.

HY-P83354

	Phospho-Bad (Ser112) Antibody (YA3099) BAD; BBC6; BCL2L8; Bcl2 antagonist of cell death; BAD; Bcl-2-binding component 6; Bcl-2-like protein 8; Bcl2-L-8; Bcl-XL/Bcl-2-associated death promoter	WB, IP	Human, Mouse, Rat
	Phospho-Bad (Ser112) Antibody (YA3099) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-Bad (Ser112).

HY-P82998

	Bcl2 A1 Antibody (YA2743) BCL2A1; ACC-1; ACC-2; Bcl-2-like protein 5; Bcl-2-related protein A1; BCL2-related protein A1; BFL1; Bcl2-L-5; BCL2L5; GRS; HBPA1; Protein BFL-1; Protein GRS	WB, IHC-P, FC	Human, Mouse, Rat
	Bcl2 A1 Antibody (YA2743) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Bcl2 A1.

HY-P80563

	Bak Antibody 1 Publications Verification BAK1; BAK; BCL2L7; CDN1; Bcl-2 homologous antagonist/killer; Apoptosis regulator BAK; Bcl-2-like protein 7; Bcl2-L-7	WB, IHC-P, ICC/IF, IP, FC	Human, Mouse
	Bak Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to Bak.

HY-P86353

	Bak Antibody (YA6045) BAK1; BAK; BCL2L7; CDN1; Bcl-2 homologous antagonist/killer; Apoptosis regulator BAK; Bcl-2-like protein 7; Bcl2-L-7	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	Bak Antibody (YA6045) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Bak.

HY-P86326

	Bim Antibody (YA6018) BCL2L11; BIM; Bcl-2-like protein 11; Bcl2-L-11; Bcl2-interacting mediator of cell death	WB, ICC/IF, IP, ELISA	Human, Mouse, Rat
	Bim Antibody (YA6018) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Bim.

HY-P80027

	Bax Antibody (YA825) 3 Publications Verification Apoptosis regulator BAX; BAX; Bcl-2-like protein 4; BCL2-associated X protein; Bcl2-L-4; BCL2L4	WB, IHC-P	Human, Mouse, Rat
	Bax Antibody (YA825) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to Bax.

HY-P80564

	Bax Antibody (YA826) Apoptosis regulator BAX; BAX; Bcl-2-like protein 4; BCL2-associated X protein; Bcl2-L-4; BCL2L4	WB	Human, Monkey
	Bax Antibody (YA826) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to Bax.

HY-P81614

	Bcl-XL Antibody (YA1359) BCL2L1; BCL2L; BCLX; Bcl-2-like protein 1; Bcl2-L-1; Apoptosis regulator Bcl-X	FC, ELISA	Human
	Bcl-XL Antibody (YA1359) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Bcl-XL.

HY-P86554

	Bcl-XL Antibody (YA6246) BCL2L1; BCL2L; BCLX; Bcl-2-like protein 1; Bcl2-L-1; Apoptosis regulator Bcl-X	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	Bcl-XL Antibody (YA6246) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Bcl-XL.

HY-P83584

	BNIP1 Antibody (YA3329) BCL2 adenovirus E1B 19kD interacting protein 1; BNIP1; Nip1; sec20; SEC20L; Transformation-related gene 8 protein; TRG8; Vesicle transport protein SEC20	WB, IHC-P	Human, Mouse, Rat
	BNIP1 Antibody (YA3329) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to BNIP1.

HY-P86515

	Bax Antibody (YA6207) BAX; BCL2L4; Apoptosis regulator BAX; Bcl-2-like protein 4; Bcl2-L-4	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	Bax Antibody (YA6207) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Bax.

HY-P84812

	BCL2L10 Antibody (YA4509) Boo; Diva; BCL-B; bcl2-L-10	IHC-P, ICC/IF, FC, ELISA	Human
	BCL2L10 Antibody (YA4509) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to BCL2L10.

HY-P85269

	MCL1 Antibod (YA4961) MCL1; BCL2L3; Induced myeloid leukemia cell differentiation protein Mcl-1; Bcl-2-like protein 3; Bcl2-L-3; Bcl-2-related protein EAT/mcl1; mcl1/EAT	WB; ICC/IF; IP; FC	Human, Mouse, Rat
	MCL1 Antibody (YA4961) is a Rabbit-derived and non-conjugated monoclonal antibody, targeting to MCL1.

HY-P86177

	MCL1 Antibody (YA5869) MCL1; BCL2L3; Induced myeloid leukemia cell differentiation protein Mcl-1; Bcl-2-like protein 3; Bcl2-L-3; Bcl-2-related protein EAT/mcl1; mcl1/EAT	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	MCL1 Antibody (YA5869) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MCL1.

HY-P84709

	BCL2L2 Antibody (YA4406) BCLW; BCL-W; PPP1R51; BCL2-L-2	WB, IHC-P, ICC/IF, FC, ELISA	Human
	BCL2L2 Antibody (YA4406) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to BCL2L2.

HY-P87568

	BCL2L15 Antibody (YA7252)	IHC-P, IHC-F, IF-Tissue, FC, ICC/IF

HY-P84506

	Bax Antibody (YA4203) BCL2L4	WB, IHC-P, FC, ELISA	Human, Mouse, Rat, Rabbit, Monkey
	Bax Antibody (YA4203) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to Bax.

HY-P82544

	Bok Antibody (YA2289) BOKL; BCL2L9	WB	Human, Rat
	Bok Antibody (YA2289) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Bok.

HY-P84615

	Bak Antibody (YA4312) BAK; CDN1; BCL2L7; BAK-LIKE	IHC-P, FC, ELISA	Human
	Bak Antibody (YA4312) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to Bak.

HY-P82495

	BAG3 Antibody (YA2240) BAG3; BIS; BAG family molecular chaperone regulator 3; BAG-3; Bcl-2-associated athanogene 3; Bcl-2-binding protein Bis; Docking protein CAIR-1	WB	Human, Rat
	BAG3 Antibody (YA2240) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to BAG3.

HY-P86461

	BAG3 Antibody (YA6153) BAG3; BIS; BAG family molecular chaperone regulator 3; BAG-3; Bcl-2-associated athanogene 3; Bcl-2-binding protein Bis; Docking protein CAIR-1	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	BAG3 Antibody (YA6153) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to BAG3.

HY-P86374

	Beclin 1 Antibody (YA6066) Beclin-1 (Coiled-coil myosin-like BCL2-interacting protein) (Protein GT197)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	Beclin 1 Antibody (YA6066) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Beclin 1.

HY-P86329

	PUMA Antibody (YA6021) BBC3; PUMA; Bcl-2-binding component 3; JFY-1; p53 up-regulated modulator of apoptosis	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	PUMA Antibody (YA6021) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PUMA.

HY-P81259

	BAG1 Antibody (YA932) BAG1; HAP; BAG family molecular chaperone regulator 1; BAG-1; Bcl-2-associated athanogene 1	WB	Human, Mouse, Rat
	BAG1 Antibody (YA932) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to BAG1.

HY-P81259A

	BAG1 Antibody (YA933) BAG1; HAP; BAG family molecular chaperone regulator 1; BAG-1; Bcl-2-associated athanogene 1	WB, IHC-P, IP	Human
	BAG1 Antibody (YA933) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to BAG1.

HY-P82213

	SODD Antibody (YA1958) BAG4; SODD; BAG family molecular chaperone regulator 4; BAG-4; Bcl-2-associated athanogene 4; Silencer of death domains	WB, IHC-F, IHC-P, ICC/IF	Human
	SODD Antibody (YA1958) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SODD.

HY-P86277

	TP53BP2 Antibod (YA5969) TP53BP2; ASPP2; BBP; Apoptosis-stimulating of p53 protein 2 ; Bcl2-binding protein; Bbp; Renal carcinoma antigen NY-REN-51; Tumor suppressor p53-binding protein 2; 53BP2; p53-binding protein 2; p53BP2;	WB, IHC-P, ICC/IF, ICC	Human
	TP53BP2 Antibody (YA5969) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to TP53BP2.

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Cat. No.	Product Name		Classification

HY-118874A

Oblimersen sodium		Antisense Oligonucleotides
Oblimersen sodium is a *BCL-2* inhibitor targeting BCL-2 RNA. Oblimersen sodium specifically binds to the first six codons of the bcl-2 mRNA sequence, resulting in degradation of bcl-2 mRNA and induces apoptosis by down-regulating expression of Bcl-2. Oblimersen sodium can be used for cancer research ^[2] .

HY-RS01417

BCL2 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
BCL2 Rat Pre-designed siRNA Set A contains three designed siRNAs for BCL2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS01415

BCL2 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
BCL2 Human Pre-designed siRNA Set A contains three designed siRNAs for BCL2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS01416

Bcl2 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Bcl2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Bcl2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-118874

Oblimersen		Antisense Oligonucleotides
Oblimersen is a *BCL-2* inhibitor targeting BCL-2 RNA. Oblimersen specifically binds to the first six codons of the bcl-2 mRNA sequence, resulting in degradation of bcl-2 mRNA and induces apoptosis by down-regulating expression of Bcl-2. Oblimersen can be used for cancer research ^[2] .

HY-174776

Human BAX mRNA		mRNA
Human BAX mRNA encodes the human BCL2 associated X, apoptosis regulator (BAX) protein, a member of the BCL2 protein family. BAX forms a heterodimer with BCL2, and functions as an apoptotic activator. It also plays a role in the mitochondrial apoptotic process.

HY-177618A

Beclanorsen sodium SPC2996 sodium		Antisense Oligonucleotides
Beclanorsen sodium is an antisense oligonucleotide targeted to the mRNA of the Bcl-2 oncoprotein.

HY-177618

Beclanorsen SPC2996		Antisense Oligonucleotides
Beclanorsen is an antisense oligonucleotide targeted to the mRNA of the Bcl-2 oncoprotein.

HY-174635

Human IL15RA mRNA		mRNA
Human IL15RA mRNA encodes the human interleukin 15 receptor subunit alpha (IL15RA) protein, a cytokine receptor that specifically binds interleukin 15 (IL15) with high affinity. IL15RA is reported to enhance cell proliferation and expression of apoptosis inhibitor BCL2L1/BCL2-XL and BCL2.

HY-174777

Human BAK1 mRNA		mRNA
Human BAK1 mRNA encodes the human BCL2 antagonist/killer 1 (BAK1) protein, a member of the BCL2 protein family. BAK1 localizes to mitochondria, and functions to induce apoptosis. It also interacts with the tumor suppressor P53 after exposure to cell stress.

HY-RS01422

Bcl2l1 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Bcl2l1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Bcl2l1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS01426

Bcl2l10 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Bcl2l10 Rat Pre-designed siRNA Set A contains three designed siRNAs for Bcl2l10 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS01418

BCL2A1 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
BCL2A1 Human Pre-designed siRNA Set A contains three designed siRNAs for BCL2A1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS01421

BCL2L1 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
BCL2L1 Human Pre-designed siRNA Set A contains three designed siRNAs for BCL2L1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS01430

BCL2L12 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
BCL2L12 Human Pre-designed siRNA Set A contains three designed siRNAs for BCL2L12 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS01424

BCL2L10 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
BCL2L10 Human Pre-designed siRNA Set A contains three designed siRNAs for BCL2L10 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS21989

Bcl2l12 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Bcl2l12 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Bcl2l12 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS01432

BCL2L14 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
BCL2L14 Human Pre-designed siRNA Set A contains three designed siRNAs for BCL2L14 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS01425

Bcl2l10 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Bcl2l10 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Bcl2l10 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS01433

BCL2L15 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
BCL2L15 Human Pre-designed siRNA Set A contains three designed siRNAs for BCL2L15 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS01431

BCL2L13 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
BCL2L13 Human Pre-designed siRNA Set A contains three designed siRNAs for BCL2L13 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS01428

Bcl2l11 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Bcl2l11 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Bcl2l11 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS01419

Bcl2a1 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Bcl2a1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Bcl2a1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS01434

BCL2L2 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
BCL2L2 Human Pre-designed siRNA Set A contains three designed siRNAs for BCL2L2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS01435

Bcl2l2 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Bcl2l2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Bcl2l2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS01436

Bcl2l2 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Bcl2l2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Bcl2l2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS01423

Bcl2l1 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Bcl2l1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Bcl2l1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS28507

Bcl2l12 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Bcl2l12 Rat Pre-designed siRNA Set A contains three designed siRNAs for Bcl2l12 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS01427

BCL2L11 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
BCL2L11 Human Pre-designed siRNA Set A contains three designed siRNAs for BCL2L11 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS01429

Bcl2l11 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Bcl2l11 Rat Pre-designed siRNA Set A contains three designed siRNAs for Bcl2l11 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-153494A

Rosomidnar sodium PNT100 sodium		Antisense Oligonucleotides
PNT100 sodium is a 24-base, chemically unmodified DNA oligonucleotide sequence that is complementary to the regulatory region upstream of the BCL-2 gene. Exposure of tumor cells to PNT100 results in suppression of proliferation and cell death.

HY-153494

Rosomidnar PNT100		Antisense Oligonucleotides
PNT100 is a 24-base, chemically unmodified DNA oligonucleotide sequence that is complementary to the regulatory region upstream of the BCL-2 gene. Exposure of tumor cells to PNT100 results in suppression of proliferation and cell death.

HY-RS01420

Bcl2a1a Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Bcl2a1a Mouse Pre-designed siRNA Set A contains three designed siRNAs for Bcl2a1a gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-126437

Poly-L-lysine hydrobromide (MW 30000-70000) 1 Publications Verification		Polymers
Poly-L-lysine hydrobromide (MW 30000-70000) is a water-soluble synthetic polypeptide. Poly-L-lysine hydrobromide (MW 30000-70000) downregulates *Bcl-2* and upregulates Bax and p53 proteins. Poly-L-lysine hydrobromide (MW 30000-70000) promotes Apoptosis and reduces VEGF expression. Poly-L-lysine hydrobromide (MW 30000-70000) shows anticancer activity against a variety of tumors. Poly-L-lysine hydrobromide (MW 30000-70000) can also be used as a coating material ^[2] .

HY-147081

AS 1411 2 Publications Verification AGRO-100		Aptamers
AS 1411 (AGRO-100) is an oligonucleotide aptamer targeting nucleoproteins. AS 1411 inhibits tumor cell proliferation by affecting the activity of nucleoprotein-containing complexes and can be used as a carrier to precisely deliver nanoparticles, oligonucleotides and small molecules to cancer cells. AS 1411 reduces PRMT5 expression to inhibit tumor growth in DU145 prostate cancer cells. AS 1411 works by blocking the binding of nucleoproteins to *bcl-2* mRNA in MCF-7 breast cancer cells. AS 1411-coupled Jin nanospheres can inhibit breast cancer cell proliferation in vitro and in mouse models, has the ability to cross the blood-brain barrier with low tissue toxicity ^[2] .

HY-N0171

Beta-Sitosterol (purity>80%) Maximum Cited Publications 15 Publications Verification		Cholesterol
Beta-Sitosterol (purity≥80%) is orally active. Beta-Sitosterol exhibits multiple activities, including anti-inflammatory, anticancer, antioxidant, antimicrobial, antidiabetic, antioxidant enzyme, and analgesic. Beta-Sitosterol inhibits inflammation and impaired adipogenesis in bovine mammary epithelial cells by reducing levels of ROS, TNF-α, IL-1β, and NF-κB p65 and restoring the activity of the HIF-1α/mTOR signaling pathway. Beta-Sitosterol induces apoptosis in cancer cells through ROS-mediated mitochondrial dysregulation and p53 activation. Beta-Sitosterol exerts its anticancer effects in cancer cells by activating caspase-3, caspase-8, and caspase-9, mediating PARP inactivation, MMP loss, altered *Bcl-2-Bax* ratio, and cytochrome c release. Beta-Sitosterol modulates macrophage polarization and reduces rheumatoid inflammation in mice. Beta-Sitosterol inhibits tumor growth in multiple mouse cancer models. Beta-Sitosterol can be used in the research of arthritis, lung cancer, breast cancer and other cancers, diabetes, etc ^[2] .

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