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  5. BAG3 Antibody (YA2240)

BAG3 Antibody (YA2240)

Cat. No.: HY-P82495
User Guide for Antibodies Technical Support

BAG3 Antibody (YA2240) is a non-conjugated IgG antibody, targeting BAG3, with a predicted molecular weight of 62 kDa (observed band size: 80 kDa). BAG3 Antibody (YA2240) can be used for WB experiment in human, rat background.

For research use only. We do not sell to patients.

Size Price Stock Quantity
10 μL Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks
50 μL Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks
100 μL Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks
250 μL   Get quote  
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Top Publications Citing Use of Products

【WB: Western Blot; IHC-P: Immunohistochemistry-Paraffin; IHC-F: Immunohistochemistry-Frozen; ICC/IF: Immunocytochemistry/Immunofluorescence; IF-Tissue: Immunofluorescence-Tissue; mIHC: Multiplex Immunohistochemical; IP: Immunoprecipitation; ChIP: Chromatin Immunoprecipitation; FC: Flow Cytometry; ELISA: Enzyme Linked Immunosorbent Assay】

  • Biological Activity

  • Technical Parameters

  • Properties

  • Documentation

Description

BAG3 Antibody (YA2240) is a non-conjugated IgG antibody, targeting BAG3, with a predicted molecular weight of 62 kDa (observed band size: 80 kDa). BAG3 Antibody (YA2240) can be used for WB experiment in human, rat background.
Background

BAG3 is a co-chaperone and adapter protein that connects different classes of molecular chaperones, including heat shock proteins 70 (HSP70s) such as HSPA1A/HSP70 or HSPA8/HSC70, and small heat shock proteins (sHSPs) like HSPB8. It functions as a nucleotide-exchange factor (NEF) by promoting the release of ADP from HSP70s, which triggers client protein release. Nucleotide release is mediated through BAG3 binding to the nucleotide-binding domain (NBD) of HSP70s, while client release occurs via binding to the substrate-binding domain (SBD). BAG3 exhibits anti-apoptotic activity and plays a role in HSF1 nucleocytoplasmic transport.
Gene ID
SwissProt ID
Synonyms
BAG3; BIS; BAG family molecular chaperone regulator 3; BAG-3; Bcl-2-associated athanogene 3; Bcl-2-binding protein Bis; Docking protein CAIR-1
Molecular Weight

Predicted band size: 62 kDa; Observed band size: 80 kDa
Purity

Affinity Purified
Conjugation

Non-conjugated
Modification

Unmodified
Research Field

Cell Biology
Product Categories

Primary Antibody; Recombinant Rabbit Monoclonal Antibody
Clonality

Recombinant, Monoclonal
Host

Rabbit
Reactivity

Human, Rat
Dilution Ratio

WB: 1/500-1/1000
Application

WB
Appearance

Liquid
Formulation

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.
Isotype

IgG
Sensitivity

Endogenous
Immunogen

Recombinant protein of human Bag3
Database

Entrez Gene: 9531 Human ; 293524 Rat

SwissProt: O95817 Human ;

OMIM: 612954 Human

Documentation
User Guide for Antibodies (1077 KB)

BAG3 Antibody (YA2240) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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BAG3 Antibody (YA2240)
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HY-P82495
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