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  5. Bok Antibody (YA2289)

Bok Antibody (YA2289)

Cat. No.: HY-P82544
User Guide for Antibodies Technical Support

Bok Antibody (YA2289) is a non-conjugated IgG antibody, targeting Bok, with a predicted molecular weight of 23 kDa (observed band size: 23 kDa). Bok Antibody (YA2289) can be used for WB experiment in human, rat background.

For research use only. We do not sell to patients.

Size Price Stock Quantity
10 μL Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks
50 μL Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks
100 μL Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks
250 μL   Get quote  
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Top Publications Citing Use of Products

【WB: Western Blot; IHC-P: Immunohistochemistry-Paraffin; IHC-F: Immunohistochemistry-Frozen; ICC/IF: Immunocytochemistry/Immunofluorescence; IF-Tissue: Immunofluorescence-Tissue; mIHC: Multiplex Immunohistochemical; IP: Immunoprecipitation; ChIP: Chromatin Immunoprecipitation; FC: Flow Cytometry; ELISA: Enzyme Linked Immunosorbent Assay】

  • Biological Activity

  • Technical Parameters

  • Properties

  • Documentation

Description

Bok Antibody (YA2289) is a non-conjugated IgG antibody, targeting Bok, with a predicted molecular weight of 23 kDa (observed band size: 23 kDa). Bok Antibody (YA2289) can be used for WB experiment in human, rat background.
Background

Bok is an apoptosis regulator that functions through different apoptotic signaling pathways (PubMed:15102863, PubMed:20673843, PubMed:27076518). It acts as a pro-apoptotic protein that positively regulates the intrinsic apoptotic process in a BAX- and BAK1-dependent or -independent manner (PubMed:15102863, PubMed:27076518). In response to endoplasmic reticulum stress, it promotes mitochondrial apoptosis through downstream BAX/BAK1 activation and positive regulation of PERK-mediated unfolded protein response (By similarity). It activates apoptosis independently of heterodimerization with survival-promoting BCL2 and BCL2L1 by inducing mitochondrial outer membrane permeabilization in a BAX- and BAK1-independent manner, in response to inhibition of the ERAD-proteasome degradation system, leading to cytochrome c release (PubMed:27076518). During DNA damage response, it mediates the intrinsic apoptotic process in a TP53-dependent manner (PubMed:15102863). It plays a role in granulosa cell apoptosis through CASP3 activation (PubMed:20673843). Conversely, it functions as an anti-apoptotic protein during neuronal apoptosis by negatively regulating poly ADP-ribose polymerase-dependent cell death through modulation of neuronal calcium homeostasis and mitochondrial bioenergetics in response to NMDA excitation (By similarity). Beyond apoptosis, it may regulate trophoblast cell proliferation during early placental development by influencing G1/S transition via CCNE1 expression regulation (PubMed:19942931). It may also act as an autophagy inducer by disrupting the MCL1-BECN1 interaction (PubMed:24113155).
Gene ID
SwissProt ID
Synonyms
BOKL; BCL2L9
Molecular Weight

Predicted band size: 23 kDa; Observed band size: 23 kDa
Purity

Affinity Purified
Conjugation

Non-conjugated
Modification

Unmodified
Research Field

Cell Biology
Product Categories

Primary Antibody; Recombinant Rabbit Monoclonal Antibody
Clonality

Recombinant, Monoclonal
Host

Rabbit
Reactivity

Human, Rat
Dilution Ratio

WB: 1/500-1/1000
Application

WB
Appearance

Liquid
Formulation

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.
Isotype

IgG
Sensitivity

Endogenous
Immunogen

A synthetic peptide of human Bok
Database

Entrez Gene: 666 Human ; 29884 Rat

SwissProt: Q9UMX3 Human ; Q792S6 Rat ;

OMIM: 605404 Human

Documentation
User Guide for Antibodies (1077 KB)

Bok Antibody (YA2289) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Bok Antibody (YA2289)
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HY-P82544
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