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  4. Monoclonal Antibodies
  5. BAG1 Antibody (YA932)

BAG1 Antibody (YA932)

Cat. No.: HY-P81259
User Guide for Antibodies Technical Support

BAG1 Antibody (YA932) is a non-conjugated IgG1 antibody, targeting BAG1, with a predicted molecular weight of 39 kDa (observed band size: 52,46,33 kDa). BAG1 Antibody (YA932) can be used for WB experiment in human, mouse, rat background.

For research use only. We do not sell to patients.

Size Price Stock Quantity
10 μL Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks
50 μL Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks
100 μL Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks
250 μL   Get quote  
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Top Publications Citing Use of Products

【WB: Western Blot; IHC-P: Immunohistochemistry-Paraffin; IHC-F: Immunohistochemistry-Frozen; ICC/IF: Immunocytochemistry/Immunofluorescence; IF-Tissue: Immunofluorescence-Tissue; mIHC: Multiplex Immunohistochemical; IP: Immunoprecipitation; ChIP: Chromatin Immunoprecipitation; FC: Flow Cytometry; ELISA: Enzyme Linked Immunosorbent Assay】

  • Biological Activity

  • Technical Parameters

  • Properties

  • Documentation

Description

BAG1 Antibody (YA932) is a non-conjugated IgG1 antibody, targeting BAG1, with a predicted molecular weight of 39 kDa (observed band size: 52,46,33 kDa). BAG1 Antibody (YA932) can be used for WB experiment in human, mouse, rat background.
Background

BAG1 is a co-chaperone for HSP70 and HSC70 chaperone proteins, functioning as a nucleotide-exchange factor (NEF) that promotes ADP release from HSP70 and HSC70, thereby triggering client/substrate protein release. Nucleotide release is mediated by its binding to the nucleotide-binding domain (NBD) of HSPA8/HSC70, while substrate release is mediated by its binding to the substrate-binding domain (SBD) of HSPA8/HSC70. BAG1 inhibits the pro-apoptotic function of PPP1R15A and exhibits anti-apoptotic activity, significantly enhancing the anti-cell death function of BCL2 induced by various stimuli. Additionally, BAG1 is involved in STUB1-mediated proteasomal degradation of ESR1 in response to age-related circulating estradiol (17-beta-estradiol/E2) decline, thereby promoting neuronal apoptosis in response to ischemic reperfusion injury (By similar).
Gene ID
SwissProt ID
Synonyms
BAG1; HAP; BAG family molecular chaperone regulator 1; BAG-1; Bcl-2-associated athanogene 1
Molecular Weight

Predicted band size: 39 kDa; Observed band size: 52,46,33 kDa
Purity

Affinity Purified
Conjugation

Non-conjugated
Modification

Unmodified
Research Field

Cell Biology
Product Categories

Primary Antibody; Mouse Monoclonal Antibody
Clonality

Monoclonal
Host

Mouse
Reactivity

Human, Mouse, Rat
Dilution Ratio

WB: 1/500-1/1000
Application

WB
Appearance

Liquid
Formulation

Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.
Isotype

IgG1
Sensitivity

Transfected
Immunogen

Purified recombinant human Bag1 protein fragments expressed in E.coli.
Database

Entrez Gene: 573 Human ; 12017 Mouse ; 297994 Rat

SwissProt: Q99933 Human ; Q60739 Mouse ; B0K019 Rat

OMIM: 601497 Human

Documentation
User Guide for Antibodies (1077 KB)

BAG1 Antibody (YA932) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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BAG1 Antibody (YA932)
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