BAG1 Antibody (YA5299)

BAG1 Antibody (YA5299) is a mouse-derived and non-conjugated monoclonal antibody, targeting to Bag1. It can be applicated for WB assays, in the background of human, mouse.

BAG1 is a co-chaperone for HSP70 and HSC70 chaperone proteins, functioning as a nucleotide-exchange factor (NEF) that promotes ADP release from HSP70 and HSC70, thereby triggering client/substrate protein release. Nucleotide release is mediated by its binding to the nucleotide-binding domain (NBD) of HSPA8/HSC70, while substrate release is mediated by its binding to the substrate-binding domain (SBD) of HSPA8/HSC70. BAG1 inhibits the pro-apoptotic function of PPP1R15A and exhibits anti-apoptotic activity, significantly enhancing the anti-cell death function of BCL2 induced by various stimuli. Additionally, BAG1 is involved in STUB1-mediated proteasomal degradation of ESR1 in response to age-related circulating estradiol (17-beta-estradiol/E2) decline, thereby promoting neuronal apoptosis in response to ischemic reperfusion injury (By similar).

Q99933

Observed band size: 52,46，33 kDa

affinity chromatography.

Non-conjugated

Unmodified

Primary Antibody; Mouse Monoclonal Antibody

Monoclonal

Mouse

Human, Mouse

Rat

WB: 1:1000

WB

Liquid

Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

Transfected

Purified recombinant human Bag1 protein fragments expressed in E.coli.