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By Research Areas:	Cancer (198) Cardiovascular Disease (41) Endocrinology (16) Infection (321) Inflammation/Immunology (90) Metabolic Disease (49) Neurological Disease (133)
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Oligonucleotides:	Nucleotides and their Analogs (4) A (1) Nucleosides and their Analogs (6) C (4) Nucleoside Phosphoramidites (1) Aptamers (3) G (1) I (1) Cap Analogs (1)

737

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

MCE Kits

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oligonucleotides

Targets Recommended: Reverse Transcriptase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-130241

Reverse transcriptase-IN-1	HIV	Infection
Reverse transcriptase-IN-1 (Compound 12z), a diarylbenzopyrimidine (DABP) analogue, is a potent, orally active *HIV-1 nonnucleoside reverse* transcriptase** inhibitor. Reverse transcriptase-IN-1 has antiviral activity with EC₅₀ values of 3.4 nM, 4.3 nM and 3.6 nM for HIV-1 III_B, E138K and K103N mutants, respectively. Reverse transcriptase-IN-1 also has an IC₅₀of 13.7 nM against *HIV-1 reverse* transcriptase enzyme** .

HY-W010696

Reverse T3 2 Publications Verification 3′,5′,3-Triiodothyronine	Thyroid Hormone Receptor	Cardiovascular Disease
Reverse T3 is a thyroid hormone that can be generated by deiodination of the prohormone thyroxine . Reverse T3 inhibits the increase of sodium current generated by other thyroid hormone analogs in neonatal rat myocytes .

HY-W010696AS

Reverse T3-13C6 hydrochloride 3′,5′,3-Triiodothyronine-¹³C₆ hydrochloride	Thyroid Hormone Receptor Isotope-Labeled Compounds	Others
Reverse T3- ¹³C₆ (hydrochloride) is the ¹³C labeled Reverse T3 .

HY-14920

Dexelvucitabine reverset; d-d4FC	Reverse Transcriptase HIV	Infection
Dexelvucitabine (Reverset; d-d4FC), a Cytidine (HY-B0158) analog, is an orally active *nucleoside reverse* transcriptase inhibitor. Dexelvucitabine is a powerful agent against HIV-1-resistant viruses containing a thymidine analog and/or M184V mutation in the viral polymerase. Dexelvucitabine is a 2′-Deoxycytidine antiretroviral** agent .

HY-131161

*M-MLV Reverse* transcriptase** M-MLV RT	Reverse Transcriptase	Infection
M-MLV Reverse transcriptase (M-MLV RT) is a kind of Reverse transcriptase, from the moroni mouse leukemia virus (MoMLV) .

HY-152233

Reverse transcriptase-IN-4	HIV	Infection
Reverse transcriptase-IN-4 (compound F10) is a potent and selective non-nucleoside reverse transcriptase (NNRT) inhibitor with an EC₅₀ value of 0.053 μM for wild-type HIV-1 and an EC₅₀ value of 0.26 μM for HIV-1 mutant E138K . Reverse transcriptase-IN-4 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-151938

Reverse transcriptase-IN-3	HIV	Infection
Reverse transcriptase-IN-3 is a pyrimidine-5-carboxamide derivative, acts as an inhibitor of HIV-1. Reverse transcriptase-IN-3 shows potent activity against the HIV-1 wild-type and mutant strains .

HY-W010696R

Reverse T3 (Standard) 3′,5′,3-Triiodothyronine (Standard)	Reference Standards Thyroid Hormone Receptor	Cardiovascular Disease
Reverse T3 (Standard) is the analytical standard of Reverse T3. This product is intended for research and analytical applications. Reverse T3 is a thyroid hormone that can be generated by deiodination of the prohormone thyroxine . Reverse T3 inhibits the increase of sodium current generated by other thyroid hormone analogs in neonatal rat myocytes .

HY-W779345

Reverse T3-13C6 3′,5′,3-Triiodothyronine-¹³C₆	Isotope-Labeled Compounds	Others
3,3',5'-Triiodo-L-thyronine- ¹³C₆ is ¹³C labeled 3,3',5'-Triiodo-L-thyronine .

HY-E70403

*Warm-Start M-MLV Reverse* Transcriptase**	Biochemical Assay Reagents	Others
Warm-Start M-MLV Reverse Transcriptase is a reverse transcriptase active below 37°C and can completely release reverse transcription activity at 55°C without affecting cDNA synthesis .

HY-118632

BILR 355	Reverse Transcriptase HIV	Infection
BILR 355 is a second-generation nonnucleoside reverse transcriptase inhibitor (NNRTI). BILR 355 is highly specific toward *HIV-1 reverse* transcriptase** (RT). BILR 355 can be used for HIV infections research .

HY-135330

Lamivudine-13C,15N2	HIV Reverse Transcriptase	Infection
Lamivudine- ¹³C, ¹⁵N₂ is a labelled impurity of Lamivudine (BCH-189). Lamivudine is a nucleoside reverse transcriptase inhibitors (NRTIs), and can inhibit HIV reverse transcriptase 1/2 and the reverse transcriptase of hepatitis B virus .

HY-P1311

RLLFT-NH2	Drug Isomer	Others
RLLFT-NH2 is a reversed amino acid sequence negative control peptide for TFLLR-NH2 .

HY-114634

Mesoxalate Ketomalonic acid; Mesoxalic acid; Oxomalonic acid	HIV	Infection
Mesoxalate (Ketomalonic acid) a dicarboxylic acid and a ketonic acid which blocks HIV-1 reverse transcriptase (RT), with the IC₅₀ of 2.2 μM .

HY-19111

R-82150 TIBO-R 82150	HIV Reverse Transcriptase	Infection
R-82150 (TIBO-R 82150) is an *HIV-1 reverse* transcriptase** inhibitor that blocks the reverse transcription of viral RNA by binding to the non-substrate binding site of reverse transcriptase, thereby inhibiting viral replication. R-82150 does not inhibit the replication of HIV-2, other RNA viruses, and DNA viruses .

HY-107001

DPC 961 (S)-DPC 961; DMP 961	HIV Reverse Transcriptase	Infection
DPC 961 (DMP 961) is a non-nucleoside reverse transcriptase inhibitor (NNRTI). DPC 961 is a potent and specific inhibitor of *HIV-1 reverse* transcriptase, which inhibits the activity of HIV-1 reverse transcriptase** in a non-competitive manner, thereby preventing viral replication. DPC 961 can be used for research on AIDS .

HY-168476

BRN3OMe	HIV	Infection
BRN3OMe is a potent *HIV-1 reverse* transcriptase** inhibitor. BRN3OMe has the potential for the research of antiviral agent .

HY-P1311A

RLLFT-NH2 TFA	Protease Activated Receptor (PAR)	Others
RLLFT-NH2 TFA is a reversed amino acid sequence negative control peptide for TFLLR-NH2 (HY-P0226) .

HY-162461

HIV-1 inhibitor-66	Reverse Transcriptase HIV	Infection
HIV-1 inhibitor-66 is an orally active non-nucleoside reverse transcription inhibitor (NNRTI). HIV-1 inhibitor-66 shows inhibitory activity against wild-type *HIV-1 reverse* transcriptase with an IC₅₀** of 40 nM .

HY-138592

7-Deaza-2',3'-dideoxyguanosine 7-Deaza-ddG	HIV	Infection
7-Deaza-2',3'-dideoxyguanosine (7-Deaza-ddG) is a 2′,3′-dideoxynucleoside 5′-triphosphate, which can inhibit *HIV-1 reverse* transcriptase with a K_i** of 25 nM .

HY-117477

DPC 963	Reverse Transcriptase HIV	Infection
DPC-963 is an oral active *non-nucleoside reverse* transcriptase inhibitor with the IC₅₀** of 18 nM. DPC-963 can be used for study of HIV .

HY-146031

A3N19	HIV	Infection
A3N19 is a potent *HIV-1 non-nucleoside reverse* transcriptase inhibitor, with an EC₅₀** of 3.28 nM against HIV-1 IIIB .

HY-159984

HIV-1 inhibitor-78	HIV	Infection
HIV-1 inhibitor-78 (compound 15f) is a potent and broad-spectrum *non-nucleoside reverse* transcriptase inhibitor, with an EC₅₀ of 3 nM for wild-type HIV-1**. HIV-1 inhibitor-78 can be used for the research of HIV infection .

HY-122935

Nigranoic acid	HIV Reverse Transcriptase	Infection
Nigranoic acid is a triterpenoid separated from Schisandra chinensis. Nigranoic acid inhibits *HIV-1 reverse* transcriptase**. Nigranoic acid exhibits protective effects on brain through PARP/AIF signaling pathway in cerebral ischemia-reperfusion animal model .

HY-N1034

12-Oxocalanolide A (±)-12-Oxocalanolide A	HIV	Infection
12-Oxocalanolide A (compound 6) is a potent inhibitor of reverse transcriptase from human immunodeficiency virus type 1 (HIV-1) with an IC₅₀ and EC₅₀ of 2.8 and 12 μM, respectively. 12-Oxocalanolide A is the analogue of Calanolide .

HY-N7232

Limocrocin	Reverse Transcriptase	Infection
Limochromin is a pigment produced by Streptomyces limosus that strongly inhibits the reverse transcriptase of avian myeloid leukemia virus (AMV). The inhibitory activity of limochromin is not affected by changes in the concentration of template-primer, substrate or carrier protein, but its inhibitory effect is significantly reduced when the concentration of AMV reverse transcriptase increases. Limochromin can be used to develop antiviral treatments .

HY-P2039

Retrobradykinin	Bradykinin Receptor Endogenous Metabolite	Cardiovascular Disease Endocrinology
Retrobradykinin has the reverse sequence of Bradykinin (HY-P0206). Retrobradykinin exhibits no kinin activity and can be used as a negative control for Bradykinin .

HY-118423

SJ-3366 IQP-0410	HIV	Inflammation/Immunology
SJ-3366 (IQP-0410) is a potent inhibitor of HIV nonnucleoside reverse transcriptase . SJ-3366 (IQP-0410) inhibits HIV at sub-nanomolar concentrations primarily through a typical non-nucleoside mechanism .

HY-14294

Capravirine S-1153	Reverse Transcriptase HIV	Infection
Capravirine (S-1153) is an orally active non-nucleoside reverse transcriptase inhibitor (NNRTI) with potent antiviral activity. Capravirine inhibits replication of HIV-1 strains that are resistant to nucleoside/nucleotide reverse transcriptase inhibitors and other NNRTIs. Capravirine is metabolized by the cytochrome P450 enzyme CYP3A4 .

HY-116154

Metacavir	Reverse Transcriptase HBV	Infection
Metacavir is an orally active, potent and specific *nucleoside reverse* transcriptase** inhibitor against hepatitis B virus (HBV) with antiviral activity .

HY-132291

HIV-1 inhibitor-8	HIV	Infection
HIV-1 inhibitor-8 is an orally active, low-toxicity and potent HIV‑1 non-nucleoside reverse transcriptase inhibitor (NNRTI). HIV-1 inhibitor-8 yields exceptionally potent antiviral activities (EC₅₀=4.44~54.5 nM) against various HIV‑1 strains. The IC₅₀ of HIV-1 inhibitor-8 against WT HIV-1 reverse transcriptase is 0.081 μM .

HY-136548

Tenofovir diphosphate TFV-DP	Reverse Transcriptase HIV	Infection Inflammation/Immunology
Tenofovir diphosphate is an antiretroviral agent. Tenofovir diphosphate is an inhibitor of HIV reverse transcriptase DNA (K_i = 1.55 μM) and RNA (K_i = 0.022 μM). Tenofovir diphosphate can be used for the research of AIDS .

HY-P1310

VKGILS-NH2 1 Publications Verification	Protease Activated Receptor (PAR)	Inflammation/Immunology
VKGILS-NH2 is a reversed amino acid sequence control peptide for SLIGKV-NH2 (protease-activated receptor 2 (PAR2) agonist). VKGILS-NH2 has no effect on DNA synthesis in cells .

HY-127078

Salaspermic acid	HIV	Others
Salaspermic acid is a new triterpene acid isolated from Salacia macrosperma Wight. Salaspermic acid is an inhibitor of *HIV reverse* transcriptase** and HIV replication in H9 lymphocyte cells .

HY-P1310A

VKGILS-NH2 TFA	Protease Activated Receptor (PAR)	Inflammation/Immunology
VKGILS-NH2 TFA is a reversed amino acid sequence control peptide for SLIGKV-NH2 (protease-activated receptor 2 (PAR2) agonist). VKGILS-NH2 TFA has no effect on DNA synthesis in cells .

HY-149928

NNRT-IN-1	HIV	Infection
NNRT-IN-1 (compound 8r) is a potent *non-nucleoside reverse* transcriptase (NNRT) inhibitor featuring significantly anti-resistance efficacy. NNRT-IN-1 inhibits the wild-type HIV-1 and five mutant strains with EC₅₀**s in the nanomolar range. NNRT-IN-1 displays favorable pharmacokinetic properties .

HY-136548B

Tenofovir diphosphate disodium 1 Publications Verification TFV-DP disodium	HIV Reverse Transcriptase	Infection Inflammation/Immunology
Tenofovir diphosphate disodium is an antiretroviral agent. Tenofovir diphosphate disodium is an inhibitor of HIV reverse transcriptase DNA (K_i = 1.55 μM) and RNA (K_i = 0.022 μM). Tenofovir diphosphate disodium can be used for the research of AIDS .

HY-105240

Delparantag PMX-60056	Factor Xa	Cardiovascular Disease
Delparantag (PMX-60056) is a salicylamide derivative and an effective unfractionated heparin (UFH) and low molecular weight heparin (LMWH) reversing agent. Delparantag shows ability to neutralize the anticoagulation and bleeding effects of UFH and LMWH .

HY-136548A

Tenofovir diphosphate triethylamine TFV-DP triethylamine	Reverse Transcriptase HIV	Infection Inflammation/Immunology
Tenofovir diphosphate triethylamine is an antiretroviral agent. Tenofovir diphosphate triethylamine is an inhibitor of HIV reverse transcriptase DNA (K_i = 1.55 μM) and RNA (K_i = 0.022 μM). Tenofovir diphosphate triethylamine can be used for the research of AIDS .

HY-146308

HIV-1 inhibitor-26	HIV	Infection
HIV-1 inhibitor-26 (compound 9a) is a potent *HIV-1 reverse* transcriptase (RT) inhibitor with an IC₅₀ value of 1.4 μM. HIV-1 inhibitor-26 has low cytotoxicity with a CC₅₀** of 1486 μM in PBMCs. HIV-1 inhibitor-26 can be used for researching AIDS .

HY-19925

AIC-292	HIV	Infection
AIC-292 is a potent and selective inhibitor of HIV-1 nonnucleoside reverse transcriptase. AIC-292 inhibits wild-type HIV-1 laboratory strains at low nanomolar concentrations. AIC-292 displays potent antiviral in vivo efficacy in a mouse xenograft model. AIC-292 has the potential for the research of HIV-1 infection .

HY-19509

IQP-0528	Reverse Transcriptase HIV	Infection
IQP-0528 is a highly potent *nonnucleoside reverse* transcriptase inhibitor** (NNRTI). IQP-0528 shows nanomolar activity against both HIV-1 and HIV-2, with EC₅₀s of 0.2 nM and 100 nM, respectively .

HY-N13716

Lucidenic acid O	DNA/RNA Synthesis HIV Reverse Transcriptase	Infection
Lucidenic acid O is a terpene compound, is a DNA polymerases inhibitor. Lucidenic lactone inhibits calf DNA polymerase-α, rat DNA polymerase-β, and *HIV-1 reverse* transcriptase with IC₅₀** values of 42 μM, 99 μM, and 69 μM, respectively .

HY-172996

NNRT-IN-8	HIV Reverse Transcriptase	Infection
NNRT-IN-8 (compound 9K) is a potent *non-nucleoside reverse* transcriptase inhibitor with EC₅₀** values of 0.0014, 0.0041, 0.0077 µM for WT HIV-1, K103N, E138K, respectively .

HY-N13712

Lucidenic lactone	DNA/RNA Synthesis HIV Reverse Transcriptase	Infection
Lucidenic lactone is a terpene compound, is a DNA polymerase inhibitor. Lucidenic lactone inhibits calf DNA polymerase-α, rat DNA polymerase-β, and *HIV-1 reverse* transcriptase with IC₅₀** values of 42 μM, 99 μM, and 69 μM, respectively .

HY-116454

GSK5750	Reverse Transcriptase HIV	Infection
GSK5750 is a specific and potent *HIV-1 reverse* transcriptase ribonuclease H inhibitor with an IC₅₀** value of 0.33 μM. GSK5750 is bound at the RNase H active site through a metalion chelation mechanism .

HY-121075

Alizarin complexone	Reverse Transcriptase	Infection
Alizarin complexone is a calcium-tracer and a chelating agent. Alizarin complexone is Rous-associated virus 2 reverse transcriptase (RAV-2 RT) inhibitor .

HY-152200

HIV-1 inhibitor-53	HIV Protease Reverse Transcriptase	Infection Inflammation/Immunology
HIV-1 inhibitor-53 is a *dual HIV-1 protease and reverse* transcriptase** inhibitor. HIV-1 inhibitor-53 inhibits HIV-1 protease (PR) and reverse transcriptase (RT) activity with IC₅₀ values of 1.93 nM and 2.35 μM, respectively. HIV-1 inhibitor-53 can be used for the research of acquired immune deficiency syndrome (AIDS) .

HY-W325699

HIV-1 inhibitor-48	HIV Reverse Transcriptase	Infection
HIV-1 inhibitor-48 (compound 13o) is a novel non-nucleoside reverse transcriptase inhibitor (NNRTI) and exhibits anti-HIV-1 activity .

HY-15353

Emivirine MKC-442	HIV	Infection Inflammation/Immunology
Emivirine (MKC-442) is a *non-nucleoside reverse* transcriptase inhibitors (NNRTIs) with K_i** values of 0.20 and 0.01 μM for dTTP- and dGTP-dependent DNA or RNA polymerase activity, respectively. Emivirine displays potent and selective anti-human immunodeficiency virus type 1 (HIV-1) activity .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-122935

Nigranoic acid	Infection Triterpenes Classification of Application Fields Terpenoids Source classification Plants Schisandraceae Disease Research Fields Schisandra chinensis (Turcz.) Baill.	HIV Reverse Transcriptase
Nigranoic acid is a triterpenoid separated from Schisandra chinensis. Nigranoic acid inhibits *HIV-1 reverse* transcriptase**. Nigranoic acid exhibits protective effects on brain through PARP/AIF signaling pathway in cerebral ischemia-reperfusion animal model .

HY-N0365

Sennoside A 3 Publications Verification	Infection Quinones Structural Classification Classification of Application Fields Leguminosae Anthraquinones Source classification Folium Sennae Cassia angustifolia Vahl Cassia acutifolia Del. Plants Disease Research Fields	HIV
Sennoside A is an anthraquinone glycoside found in senna (Cassia angustifolia). Sennoside A is an HIV-1 inhibitor (IC₅₀=3.8 μM) that inhibits HIV-1 replication. Sennoside A also inhibits HIV-1 reverse transcriptase (RT)-related DNA polymerase (RDDP) and ribonuclease H (Ribonuclease H) with IC₅₀s of 1.9 μM and 5.3 μM, respectively .

HY-N0453

Hypericin 5 Publications Verification	Structural Classification Natural Products Classification of Application Fields Guttiferae Source classification Phenols Polyphenols Hyperlcurn perforatum L. Plants Disease Research Fields Cancer	Apoptosis Influenza Virus Antibiotic Monoamine Oxidase PKC Cytochrome P450 Dopamine β-hydroxylase Reverse Transcriptase Telomerase
Hypericin is a naturally occurring substance found in Hyperlcurn perforatum L. Hypericin is an inhibitor of PKC (protein kinase C), MAO (monoaminoxidase), dopamine-beta-hydroxylase, reverse transcriptase, telomerase and CYP (cytochrome P450). Hypericin shows antitumor, antiviral, antidepressive activities, and can induce apoptosis .

HY-N7232

Limocrocin	Structural Classification Natural Products Microorganisms Source classification	Reverse Transcriptase
Limochromin is a pigment produced by Streptomyces limosus that strongly inhibits the reverse transcriptase of avian myeloid leukemia virus (AMV). The inhibitory activity of limochromin is not affected by changes in the concentration of template-primer, substrate or carrier protein, but its inhibitory effect is significantly reduced when the concentration of AMV reverse transcriptase increases. Limochromin can be used to develop antiviral treatments .

HY-127078

Salaspermic acid	Triterpenes Structural Classification Salacia macrosperma Wight Terpenoids Source classification Celastraceae Plants	HIV
Salaspermic acid is a new triterpene acid isolated from Salacia macrosperma Wight. Salaspermic acid is an inhibitor of *HIV reverse* transcriptase** and HIV replication in H9 lymphocyte cells .

HY-N13716

Lucidenic acid O	Triterpenes Structural Classification Microorganisms Terpenoids Source classification	DNA/RNA Synthesis HIV Reverse Transcriptase
Lucidenic acid O is a terpene compound, is a DNA polymerases inhibitor. Lucidenic lactone inhibits calf DNA polymerase-α, rat DNA polymerase-β, and *HIV-1 reverse* transcriptase with IC₅₀** values of 42 μM, 99 μM, and 69 μM, respectively .

HY-N13712

Lucidenic lactone	Other Terpenoids Structural Classification Microorganisms Terpenoids Source classification	DNA/RNA Synthesis HIV Reverse Transcriptase
Lucidenic lactone is a terpene compound, is a DNA polymerase inhibitor. Lucidenic lactone inhibits calf DNA polymerase-α, rat DNA polymerase-β, and *HIV-1 reverse* transcriptase with IC₅₀** values of 42 μM, 99 μM, and 69 μM, respectively .

HY-130050

Luzopeptin A BBM-928 A	Structural Classification Microorganisms Antibiotics Source classification	Antibiotic HIV
Luzopeptin A (BBM-928 A) is an actinoleukin-like antitumor antibiotic. Luzopeptin A is a bifunctional DNA intercalator which can interact with isolated DNA molecules. Luzopeptin A induces an unwinding-rewinding process of the closed superhelical PM2 DNA. Luzopeptin A is active against HIV-1 and HIV-2 reverse transcriptase with IC₅₀s of 7 nM and 68 nM for HIV-1 RT and HIV-2 RT, respectively .

HY-N14284

Mniopetal A	Structural Classification Microorganisms Terpenoids Sesquiterpenes Source classification	Reverse Transcriptase
Mniopetal A is a reverse transcriptase inhibitor found in Mniopetalum sp. 87256 .

HY-N14288

Mniopetal E	Structural Classification Microorganisms Terpenoids Sesquiterpenes Source classification	Reverse Transcriptase
Mniopetal E is a reverse transcriptase inhibitor found in Mniopetalum sp. 87256 .

HY-N14285

Mniopetal B	Structural Classification Microorganisms Terpenoids Sesquiterpenes Source classification	Reverse Transcriptase
Mniopetal B is a reverse transcriptase inhibitor found in Mniopetalum sp. 87256 .

HY-N14287

Mniopetal D	Structural Classification Microorganisms Terpenoids Sesquiterpenes Source classification	Reverse Transcriptase
Mniopetal D is a reverse transcriptase inhibitor found in Mniopetalum sp. 87256 .

HY-N14289

Mniopetal F	Structural Classification Microorganisms Terpenoids Sesquiterpenes Source classification	Reverse Transcriptase
Mniopetal F is a reverse transcriptase inhibitor found in Mniopetalum sp. 87256 .

HY-N14286

Mniopetal C	Structural Classification Microorganisms Terpenoids Sesquiterpenes Source classification	Reverse Transcriptase
Mniopetal C is a reverse transcriptase inhibitor found in Mniopetalum sp. 87256 .

HY-N0459

3,5-O-Dicaffeoylquinic acid 1 Publications Verification	other families Simple Phenylpropanols Source classification Phenylpropanoids Plants	Others
3,5-O-Dicaffeoylquinic acid reverses Trimethyltin-induced learning and memory deficits .

HY-B1744

Pyridoxal phosphate 1 Publications Verification Pyridoxal 5′-phosphate; Pyridoxyl phosphate	Structural Classification Human Gut Microbiota Metabolites Immune System Disorder Microorganisms Ketones, Aldehydes, Acids Source classification Disease markers Endocrine diseases Nervous System Disorder Endogenous metabolite	Reverse Transcriptase Endogenous Metabolite ERK Amyloid-β
Pyridoxal phosphate is the active form of vitamin B6, acts as an inhibitor of reverse transcriptases, and is used for the treatment of tardive dyskinesia.

HY-N2571

Corydine	Infection Alkaloids Monophenols other families Classification of Application Fields Source classification Phenols Plants Isoquinoline Alkaloids Disease Research Fields	Reverse Transcriptase HIV
Corydine is a naturally occurring alkaloid which can be extracted from plants such as Croton echinocarpus leaves. Corydine is efficient on inhibiting reverse transcriptase (RT) activity with an IC₅₀ of 356.8 μg/mL. Corydine displays significant in vitro anti-HIV potential, inhibiting 40% of the HIV-1 reverse transcriptase enzyme activity at a concentration of 450 μg/mL of Corydine .

HY-17427

Emtricitabine 5 Publications Verification BW1592	Infection Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields	HIV Reverse Transcriptase Endogenous Metabolite
Emtricitabine is a nucleoside reverse transcriptase inhibitor (NRTI) with an EC₅₀ of 0.01 μM in PBMC cell. It is an antiviral agent for the treatment of HIV infection.

HY-10571

Delavirdine 3 Publications Verification U 90152; BHAP-U 90152	Infection Classification of Application Fields Disease Research Fields	HIV Reverse Transcriptase
Delavirdine (U 90152) is a potent, highly specific and orally active *non-nucleoside reverse* transcriptase** inhibitor (NNRTI). Delavirdine selectively inhibits HIV-1 reverse transcriptase (RT) (IC₅₀=0.26 μM) over DNA polymerase α (IC₅₀=440 μM) and polymerase δ (IC₅₀>550 μM). Delavirdine is an inhibitor of HIV-1 replication and can can be used for the study of AIDs .

HY-N3981

Guajadial	Structural Classification Natural Products Source classification Psidium guajava Linn. Myrtaceae Plants	Others
Guajadial, a caryophyllene-based meroterpenoid, has anti-estrogenic and anticancer effect. Guajadial reverses multidrug resistance in cancer. Guajadial can be isolated from Psidium guajava leaves .

HY-N2103

Tenacissoside G	Structural Classification other families Classification of Application Fields Source classification Plants Disease Research Fields Steroids Cancer	P-glycoprotein
Tenacissoside G is a C21 steroid from the stems of Marsdenia tenacissima. Tenacissoside G reverses multidrug resistance in P-glycoprotein (Pgp)-overexpressing multidrug-resistant cancer cells .

HY-N14666

Agrocybin	Structural Classification Natural Products Microorganisms Source classification	Fungal HIV Reverse Transcriptase
Agrocybin is an antifungal peptide that exerts antifungal activity against several fungal species but lacks inhibitory activity against bacteria. Agrocybin attenuates the activity of *HIV-1 reverse* transcriptase** .

HY-B1744R

Pyridoxal phosphate (Standard) Pyridoxal 5′-phosphate (Standard); Pyridoxyl phosphate (Standard)	Structural Classification Human Gut Microbiota Metabolites Immune System Disorder Microorganisms Ketones, Aldehydes, Acids Source classification Disease markers Endocrine diseases Nervous System Disorder Endogenous metabolite	Reference Standards Reverse Transcriptase Endogenous Metabolite
Pyridoxal phosphate (Standard) is the analytical standard of Pyridoxal phosphate. This product is intended for research and analytical applications. Pyridoxal phosphate is the active form of vitamin B6, acts as an inhibitor of reverse transcriptases, and is used for the treatment of tardive dyskinesia.

HY-N1251

Scholaricine	Apocynaceae Structural Classification Alkaloids Alstonia spatulata Blume Other Alkaloids Source classification Plants	Others
Scholaricine (compound 13 ) is an alkaloid isolated from the leaf and stem-bark extracts of Alstonia spatulata. Scholaricine reverse multidrug resistance in vincristine-resistant KB cells with an IC₅₀ value of 13.35 μM .

HY-N1916

Coniferyl ferulate	Structural Classification Classification of Application Fields Simple Phenylpropanols Source classification Phenols Polyphenols Dicerothamnus rhinocerotis Phenylpropanoids Umbelliferae Plants Disease Research Fields Cancer	Glutathione S-transferase P-glycoprotein
Coniferyl ferulate, a strong inhibitor of glutathione S-transferase (GST), reverses multidrug resistance and downregulates P-glycoprotein. Coniferyl ferulate shows strong inhibition of human placental GST with an IC50 of 0.3 μM.

HY-17427R

Emtricitabine (Standard) BW1592 (Standard)	Structural Classification Natural Products Source classification Endogenous metabolite	Reference Standards HIV Reverse Transcriptase Endogenous Metabolite
Emtricitabine (Standard) is the analytical standard of Emtricitabine. This product is intended for research and analytical applications. Emtricitabine is a nucleoside reverse transcriptase inhibitor (NRTI) with an EC₅₀ of 0.01 μM in PBMC cell. It is an antiviral agent for the treatment of HIV infection.

HY-150177

Mannose 6 phosphate	Human Gut Microbiota Metabolites Microorganisms Source classification Endogenous metabolite	Endogenous Metabolite
Mannose 6 phosphate is a source of energy for cellular metabolism through their involvement in glycolysis. Mannose 6 phosphate can protect proteins in the dermis scaffold against oxidation and degradation. Mannose 6 phosphate can reverse the visible signs of aging .

HY-N3312

Matairesinol	Infection Structural Classification other families Classification of Application Fields Anti-aging Source classification Lignans Phenols Polyphenols Phenylpropanoids Plants Disease Research Fields	Endogenous Metabolite
Matairesinol confers anti-allergic effects in an allergic dermatitis mouse model. DfE-induced changes in IL-4 and IFN-γ mRNA expression in the ears of NC/Nga mice were reversed by matairesinol application .

HY-10572

Efavirenz 5+ Cited Publications DMP 266; EFV; L-743726	Infection Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Cancer	Reverse Transcriptase HIV Autophagy Endogenous Metabolite Parasite
Efavirenz (DMP 266) is a potent inhibitor of the wild-type *HIV-1 reverse* transcriptase with a K_i of 2.93 nM and exhibits an IC₉₅** of 1.5 nM for the inhibition of HIV-1 replicative spread in cell culture .

HY-N1219

Stephanine (-)-Stephanine; l-Stephanine	Structural Classification Alkaloids Piperidine Alkaloids Source classification Plants Menispermaceae Stephania japonica (Thunb.) Miers	Apoptosis Parasite
Stephanine ((-)-Stephanine) is an isoquinoline aporphine-type alkaloid. Stephanine induce apoptosis through the reverse of mitotic exit. Stephanine exhibits Antiplasmodial activity. Stephanine can be used for the research of stomach pain, abdominal pain, arthritis and cancer .

HY-N0691

Schisandrin 3 Publications Verification Schizandrin; Schizandrol; Schizandrol-A	Structural Classification Classification of Application Fields Source classification Lignans Phenylpropanoids Plants Schisandraceae Schisandra chinensis (Turcz.) Baill. Disease Research Fields Cancer	Autophagy
Schisandrin (Schizandrin), a dibenzocyclooctadiene lignan, is isolated from the fruit of Schisandra chinensis Baill. Schisandrin exhibits antioxidant, hepatoprotective, anti-cancer and anti-inflammatory activities. Schisandrin also can reverses memory impairment in rats .

HY-N5166

Ardeemin (-)-Ardeemin	Structural Classification Alkaloids Microorganisms Source classification Indole Alkaloids	P-glycoprotein
Ardeemin ((-)-Ardeemin) binds to the P-glycoprotein, preventing anticancer agent from being pumped out of cells. Ardeemin reverses the multidrug resistance phenotype of tumor cells and increases the sensitivity of tumor cells to anticancer agent in mammary carcinoma xenografts .

HY-N0459R

3,5-O-Dicaffeoylquinic acid (Standard)	Structural Classification other families Simple Phenylpropanols Source classification Phenylpropanoids Plants	Reference Standards Others
3,5-O-Dicaffeoylquinic acid (Standard) is the analytical standard of 3,5-O-Dicaffeoylquinic acid. This product is intended for research and analytical applications. 3,5-O-Dicaffeoylquinic acid reverses Trimethyltin-induced learning and memory deficits .

HY-N14957

Clavicoronic acid	Structural Classification Natural Products Microorganisms Source classification	Antibiotic
Clavicoronic acid is an avian myeloblastosis virus and Moloney murine leukemia virus reverse transcriptases inhibitor with K_i values of 130, 68 µM, respectively. Clavicoronic acid inhibits the multiplication of vesicular stomatitis virus by interfering with this virus's RNA-directed RNA-polymerase. Clavicoronic acid shows no cytotoxicity .

HY-113796

Kopsoffinol	Apocynaceae Structural Classification Alkaloids Other Alkaloids Source classification Kopsia pauciflora Hook.f. Plants	Others
Kopsoffinol, a bisindole alkaloid, shows in vitro growth inhibitory activity against human PC-3, HCT-116, MCF-7, and A549 cells and moderate effects in reversing multidrug-resistance in vincristine-resistant human KB cells .

HY-N144114

P-gp inhibitor 2	Classification of Application Fields Disease Research Fields Cancer	P-glycoprotein
P-gp inhibitor 2 is a potent P-gp inhibitor. P-gp inhibitor 2 shows reverse Doxorubicin resistance (IC₅₀=0.22 µM) in P-gp overexpressing human colorectal carcinoma cells (SW600 Ad300) .

HY-N6608

Physostigmine 2 Publications Verification Eserine	Alkaloids Lablab purpureus (L.) Sweet Leguminosae Source classification Plants Indole Alkaloids	Cholinesterase (ChE)
Physostigmine (Eserine) is a reversible acetylcholinesterase (AChE) inhibitor. Physostigmine can crosses the blood-brain barrier and stimulates central cholinergic neurotransmission. Physostigmine can reverse memory deficits in transgenic mice with Alzheimer's disease. Physostigmine is also an antidote for anticholinergic poisoning .

HY-W014787

Decanedioic acid Sebacic acid	Structural Classification Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease markers Endocrine diseases Metabolic Disease Endogenous metabolite Disease Research Fields Cardiovascular System Disorder	Endogenous Metabolite
Decanedioic acid is a straight-chain dicarboxylic acid. Dodecanedioic acid overcomes metabolic inflexibility in type 2 diabetes. Decanedioic acid prevents and reverses metabolic-associated liver disease and obesity. Decanedioic acid is associated with carnitine-acylcarnitine translocase deficiency and medium chain acyl-CoA dehydrogenase deficiency .

HY-113137

N2,N2-Dimethylguanosine 3 Publications Verification	Structural Classification Natural Products Other disease Classification of Application Fields Source classification Disease markers Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite
N2,N2-Dimethylguanosine is a methylated nucleoside present in RNA and a structural modification component of tRNA. N2,N2-Dimethylguanosine hinders reverse transcriptase-mediated cDNA synthesis and is one of the key modifications that affect sequencing efficiency in high-throughput RNA sequencing. N2,N2-Dimethylguanosine can selectively remove one of the methyl groups through AlkB mutant enzymes (such as D135S/L118V) and convert it into N2-methylguanosine, thereby reducing the hindrance to reverse transcription .

HY-P1346

APETx2	Structural Classification Natural Products Animals Source classification	Sodium Channel
APETx2, a sea anemone peptide from Anthopleura elegantissima, is a selective and reversible ASIC3 inhibitor, with an IC₅₀ of 63 nM. APETx2 directly inhibits the ASIC3 channel by acting at its external side. APETx2 could reverses acid‐induced and inflammatory pain .

HY-116694

Digallic acid	Structural Classification Pistacia lentiscus var. Chia Source classification Phenols Polyphenols Plants Anacardiaceae	Apoptosis Reactive Oxygen Species (ROS) Reverse Transcriptase Xanthine Oxidase URAT1
Digallic acid is an antioxidant, antimutagenic, antigenotoxic, and anti-hyperuricemic compound. Digallic acid is a reverse transcriptase and XOD, URAT1 (IC₅₀: 5.34 μM) inhibitor. Digallic acid scavenges DPPH· and O2·− radicals. Digallic acid induces apoptosis. Digallic acid can be isolated from the fruits of Pistascia lentiscus .

HY-N3312R

Matairesinol (Standard)	Structural Classification other families Source classification Lignans Phenols Polyphenols Phenylpropanoids Plants	Reference Standards Endogenous Metabolite
Matairesinol (Standard) is the analytical standard of Matairesinol. This product is intended for research and analytical applications. Matairesinol confers anti-allergic effects in an allergic dermatitis mouse model. DfE-induced changes in IL-4 and IFN-γ mRNA expression in the ears of NC/Nga mice were reversed by matairesinol application .

HY-10572R

Efavirenz (Standard) DMP 266 (Standard); EFV (Standard); L-743726 (Standard)	Structural Classification Natural Products Source classification Endogenous metabolite	Reference Standards Reverse Transcriptase HIV Autophagy Endogenous Metabolite Parasite
Efavirenz (Standard) is the analytical standard of Efavirenz. This product is intended for research and analytical applications. Efavirenz (DMP 266) is a potent inhibitor of the wild-type *HIV-1 reverse* transcriptase with a K_i of 2.93 nM and exhibits an IC₉₅** of 1.5 nM for the inhibition of HIV-1 replicative spread in cell culture .

HY-130778

N,N'-Diacetylchitobiose	Structural Classification Microorganisms Animals Classification of Application Fields Source classification Other Diseases Disease Research Fields Saccharides	Endogenous Metabolite
N,N'-Diacetylchitobiose is a dimer of β(1,4) linked N-acetyl-D glucosamine. N,N'-Diacetylchitobiose is the hydrolysate of chitin and can be used as alternative carbon source by E. coli. N,N'-Diacetylchitobiose also reverses myocardial depression .

HY-N0691R

Schisandrin (Standard) Schizandrin (Standard); Schizandrol (Standard); Schizandrol-A (Standard)	Structural Classification Source classification Lignans Phenylpropanoids Plants Schisandraceae Schisandra chinensis (Turcz.) Baill.	Reference Standards Autophagy
Schisandrin (Standard) is the analytical standard of Schisandrin. This product is intended for research and analytical applications. Schisandrin (Schizandrin), a dibenzocyclooctadiene lignan, is isolated from the fruit of Schisandra chinensis Baill. Schisandrin exhibits antioxidant, hepatoprotective, anti-cancer and anti-inflammatory activities. Schisandrin also can reverses memory impairment in rats .

HY-142074

Inophyllum B (+)-Inophyllum B	Structural Classification Source classification Rosaceae Coumarins Phenylpropanoids Plants Photinia serratifolia (Desf.) Kalkman	Reverse Transcriptase HIV
Inophyllum B ((+)-Inophyllum B) is a potent HIV Reverse Transcriptase inhibitor with an IC₅₀ value of 38 nM. Inophyllum B inhibits HIV-1 (IC₅₀=1.4 μM) in vitro cell culture. Inophyllum B can be isolated from the acetone extract of the giant African snail, Achatina fulica .

HY-129297

CMPF	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
CMPF can be found in trace constituent of urine and blood. CMPF is a biomarker of type 2 diabetes. CMPF can act on the β cell and induces impaired mitochondrial function. CMPF decreases glucose-induced ATP accumulation, and induces oxidative stress. CMPF reverses hepatic lipid accumulation and improves insulin sensitivity in obese mice .

HY-N0088

Apocynin Maximum Cited Publications 23 Publications Verification Acetovanillone	Structural Classification Monophenols Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Orchidaceae Source classification Phenols Anoectochilus roxburghii (Wall.) Lindl. Plants Disease Research Fields Cancer	NADPH Oxidase
Apocynin is a selective NADPH-oxidase inhibitor with an IC₅₀ of 10 μM . Apocynin improves acute lung inflammation in Carrageenan (HY-125474)-induced pleurisy mice model . Apocynin can also be used for cancer research . Apocynin reverses the aging process in mesenchymal stem cells to promote osteogenesis and increases bone mass .

HY-N14349

Asterriquinone ARQ; Asterriquinone SU5504	Structural Classification Natural Products Microorganisms Source classification	EGFR HIV Reverse Transcriptase
Asterriquinone (ARQ), a Asterriquinone analog, is a Grb-2 binding inhibitor. Asterriquinone inhibits the Grb-2 binding activity to tyrosine phosphorylated EGFR, with an IC₅₀ of 8.37 μM. Asterriquinone is a *HIV1 reverse* transcriptase inhibitor with a K_i** of 2.3 μM. Asterriquinone also inhibits Grb-7 and PLC-γ binding activities. .

HY-108694

γ-Tocotrienol 1 Publications Verification	Structural Classification Monophenols Microorganisms other families Classification of Application Fields Source classification Phenols Plants Inflammation/Immunology Disease Research Fields	Endogenous Metabolite NF-κB
γ-Tocotrienol is an active form of vitamin E. γ-tocotrienol reverses the multidrug resistance (MDR) of breast cancer cells through the signaling pathway of NF-κB and P-gp. γ-Tocotrienol is also a novel radioprotector agent, can mitigate bone marrow radiation damage during targeted radionuclide treatment .

Cat. No.	Product Name	Chemical Structure

HY-W010696AS

Reverse T3-13C6 hydrochloride
Reverse T3- ¹³C₆ (hydrochloride) is the ¹³C labeled Reverse T3 .

HY-W654247

Lamivudine-13C,d2
Lamivudine- ¹³C,d₂ is the deuterium labeled and ¹³C-labeled Lamivudine. Lamivudine (BCH-189) is an orally active nucleoside reverse transcriptase inhibitor (NRTI). Lamivudine can inhibit HIV reverse transcriptase 1/2 and also the reverse transcriptase of hepatitis B virus. Lamivudine salicylate can penetrate the CNS .

HY-W779345

Reverse T3-13C6
3,3',5'-Triiodo-L-thyronine- ¹³C₆ is ¹³C labeled 3,3',5'-Triiodo-L-thyronine .

HY-135330

Lamivudine-13C,15N2
Lamivudine- ¹³C, ¹⁵N₂ is a labelled impurity of Lamivudine (BCH-189). Lamivudine is a nucleoside reverse transcriptase inhibitors (NRTIs), and can inhibit HIV reverse transcriptase 1/2 and the reverse transcriptase of hepatitis B virus .

HY-173427S

ZK-316
ZK-316 is a potent and broad-spectrum NNRTI inhibitor with an EC₅₀s ranging from 0.99 to 75.1 nM. ZK-316 can be used in the study of HIV .

HY-B0250S

Lamivudine-15N,d2
Lamivudine- ¹⁵N,d₂ is ¹⁵N and deuterated labeled Lamivudine (HY-B0250). Lamivudine (BCH-189) is an orally active *nucleoside reverse* transcriptase inhibitor (NRTI). Lamivudine can inhibit HIV reverse transcriptase 1/2** and also the reverse transcriptase of hepatitis B virus. Lamivudine salicylate can penetrate the CNS .

HY-B0250S2

Lamivudine-13C,15N3
Lamivudine- ¹³C, ¹⁵N₃ (BCH-189- ¹³C, ¹⁵N₃) is ¹³C and ¹⁵N labeled Lamivudine. Lamivudine (BCH-189) is an orally active *nucleoside reverse* transcriptase inhibitor (NRTI). Lamivudine can inhibit HIV reverse transcriptase 1/2** and also the reverse transcriptase of hepatitis B virus. Lamivudine salicylate can penetrate the CNS .

HY-B0250S1

Lamivudine-13C,15N2,d2
Lamivudine-13C,15N2,d2 (BCH-189-13C,15N2,d2) is a 13C, 15N, and deuterium labeled Lamivudine (HY-B0250). Lamivudine is an orally active and blood-brain barrier permeable nucleoside reverse transcriptase inhibitor (NRTI). Lamivudine inhibits HIV reverse transcriptase 1 and 2 and hepatitis B virus (HBV) reverse transcriptase .

HY-14266S

Dapivirine-d11
Dapivirine-d₁₁ is the deuterium labeled Dapivirine. Dapivirine (TMC120), the prototype of diarylpyrimidines (DAPY), is an orally active and nonnucleoside reverse transcriptase inhibitor (NRTI). Dapivirine (TMC120) binds directly to HIV-1 reverse transcriptase. Dapivirine (TMC120) regulates autophagy and induced Akt, Bad and SAPK/JNK activations .

HY-B0249S

Didanosine-d2
Didanosine-d₂ is the deuterium labeled Didanosine. Didanosine (Videx) is a reverse transcriptase inhibitor with an IC50 of 0.49 μM.

HY-90005S

Etravirine D4
Etravirine-d₄ is the deuterium labeled Etravirine. Etravirine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used for the treatment of HIV.

HY-17423S

Abacavir-d4
Abacavir-d₄ is the deuterium labeled Abacavir. Abacavir is a potent nucleoside analog reverse-transcriptase inhibitor (NRTI)[1][2].

HY-17413S

Zidovudine-d3
Zidovudine-d₃ is the deuterium labeled Zidovudine. Zidovudine is a nucleoside reverse transcriptase inhibitor (NRTI), widely used to treat HIV infection.

HY-14266S1

Dapivirine-d4
Dapivirine-d₄ (TMC120-d₄) is deuterium labeled Dapivirine. Dapivirine (TMC120), the prototype of diarylpyrimidines (DAPY), is an orally active and *nonnucleoside reverse* transcriptase inhibitor (NRTI)*. Dapivirine (TMC120) binds directly to HIV-1 reverse* transcriptase. Dapivirine (TMC120) regulates autophagy and induced Akt, Bad and SAPK/JNK activations .

HY-132508S

Etravirine-d8
Etravirine-d₈ is the deuterium labeled Etravirine. Etravirine (R165335) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used for the treatment of HIV .

HY-17413S2

Zidovudine-d4
Zidovudine-d₄ is deuterated labeled Zidovudine (HY-17413). Zidovudine is a nucleoside reverse transcriptase inhibitor (NRTI), widely used to treat HIV infection.

HY-16767S1

Doravirine-13C,d3
Doravirine-13C,d3 (MK-1439-13C,d3) is the deuterium labeled Doravirine (HY-16767). Doravirine (MK-1439) is a highly specific *HIV-1 nonnucleoside reverse* transcriptase inhibitor with IC₅₀s of 4.5 nM, 5.5 nM and 6.1 nM against the wild type and K103N and Y181C** reverse transcriptase mutants, respectively .

HY-113904S

(Rac)-Tenofovir-d6
(Rac)-Tenofovir-d₆ is a labelled racemic Tenofovir. Tenofovir (GS 1278) is a nucleotide reverse transcriptase inhibitor to treat HIV and chronic Hepatitis B (HBV) .

HY-17413S1

Zidovudine-13C,d3
Zidovudine- ¹³C,d₃ is the ¹³C- and deuterium labeled Zidovudine. Zidovudine is a nucleoside reverse transcriptase inhibitor (NRTI), widely used to treat HIV infection.

HY-10570S

Nevirapine-d4
Nevirapine-d₄ is deuterium labeled Nevirapine. Nevirapine is a non-nucleoside inhibitor of HIV-1 reverse transcriptase used to treat and prevent HIV/AIDS; with a K_i of 270 μM .

HY-B1744S

Pyridoxal phosphate-d5
Pyridoxal phosphate-d₅ is the deuterium labeled Pyridoxal phosphate. Pyridoxal phosphate is the active form of vitamin B6, acts as an inhibitor of reverse transcriptases, and is used for the treatment of tardive dyskinesia .

HY-10570S3

Nevirapine-d5
Nevirapine-d₅ (BI-RG 587-d₅) is deuterium labeled Nevirapine. Nevirapine is a non-nucleoside inhibitor of HIV-1 reverse transcriptase used to treat and prevent HIV/AIDS; with a K_i of 270 μM .

HY-17427S

Emtricitabine-15N,d2
Emtricitabine- ¹⁵N,d₂ is a ¹⁵N-labeled and deuterium labeled Emtricitabine. Emtricitabine is a nucleoside reverse transcriptase inhibitor (NRTI) with an EC50 of 0.01 μM in PBMC cell. It is an antiviral agent for the treatment of HIV infection.

HY-17427S4

Emtricitabine-d2
Emtricitabine-d₂ (BW1592-d₂) is deuterium labeled Emtricitabine. Emtricitabine is a nucleoside reverse transcriptase inhibitor (NRTI) with an EC₅₀ of 0.01 μM in PBMC cell. It is an antiviral agent for the treatment of HIV infection.

HY-10570S1

Nevirapine-d3
Nevirapine-d₃ (BI-RG 587-d₃) is the deuterium labeled Nevirapine. Nevirapine is a non-nucleoside inhibitor of HIV-1 reverse transcriptase used to treat and prevent HIV/AIDS; with a K_i of 270 μM .

HY-10570S2

Nevirapine-d8
Nevirapine-d₈ (BI-RG 587-d₈) is deuterium labeled Nevirapine. Nevirapine is a non-nucleoside inhibitor of HIV-1 reverse transcriptase used to treat and prevent HIV/AIDS; with a K_i of 270 μM .

HY-W777351

Etravirine-13C3
Etravirine- ¹³C₃ (R165335- ¹³C₃) is the ¹³C-labeled Etravirine (HY-90005). Etravirine (R165335; TMC125) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used for the treatment of HIV.

HY-15232S2

Tenofovir alafenamide-d6
Tenofovir alafenamide-d₆ (GS-7340-d₆) is deuterium labeled Tenofovir alafenamide. Tenofovir alafenamide (GS-7340) is an investigational oral proagent of Tenofovir. Tenofovir is a HIV-1 nucleotide reverse transcriptase inhibitor .

HY-N3312S

Matairesinol-d6
Matairesinol-d₆ is the deuterium labeled Matairesinol. Matairesinol confers anti-allergic effects in an allergic dermatitis mouse model. DfE-induced changes in IL-4 and IFN-γ mRNA expression in the ears of NC/Nga mice were reversed by matairesinol application .

HY-W653961

Tenofovir alafenamide-d5 fumarate
Tenofovir alafenamide-d₅ fumarate (GS-7340-d₅ fumarate) is the deuterium labeled Tenofovir alafenamide fumarate (HY-15232A). Tenofovir alafenamide fumarate (GS-7340 fumarate) is an investigational oral proagent of Tenofovir. Tenofovir is a HIV-1 nucleotide reverse transcriptase inhibitor.

HY-10572S1

Efavirenz-13C6
Efavirenz- ¹³C₆ is the ¹³C-labeled Efavirenz. Efavirenz (DMP 266) is a potent inhibitor of the wild-type HIV-1 reverse transcriptase with a K_i of 2.93 nM and exhibits an IC₉₅ of 1.5 nM for the inhibition of HIV-1 replicative spread in cell culture .

HY-13580S

Budesonide-d8
Budesonide-d₈ is the deuterium labeled Budesonide. Budesonide, an inhaled glucocortical steroid, is an orally active glucocorticoid receptor agonist. Budesonide decreases the size of lung tumors, reverses DNA hypomethylation and modulates mRNA expression of genes. Budesonide is an anti-inflammatory agent used for asthma .

HY-W742981

Budesonide-d6
Budesonide-d₆ is deuterium labeled Budesonide. Budesonide, an inhaled glucocortical steroid, is an orally active glucocorticoid receptor agonist. Budesonide decreases the size of lung tumors, reverses DNA hypomethylation and modulates mRNA expression of genes. Budesonide is an anti-inflammatory agent used for asthma .

HY-N6608S

Physostigmine-d3
Physostigmine-d₃ is the deuterium labeled Physostigmine. Physostigmine (Eserine) is a reversible acetylcholinesterase (AChE) inhibitor. Physostigmine can crosses the blood-brain barrier and stimulates central cholinergic neurotransmission. Physostigmine can reverse memory deficits in transgenic mice with Alzheimer's disease. Physostigmine is also an antidote for anticholinergic poisoning .

HY-17427S2

Emtricitabine-13C,15N2
Emtricitabine- ¹³C, ¹⁵N₂ (BW1592- ¹³C, ¹⁵N₂) is a ¹³C- and ¹⁵N-labeled Emtricitabine (HY-17427). Emtricitabine is a nucleoside reverse transcriptase inhibitor (NRTI) with an EC₅₀ of 0.01 μM in PBMC cell. It is an antiviral agent for the treatment of HIV infection.

HY-W014787S

Decanedioic acid-d4

Decanedioic acid-d₄ is the deuterium labeled Decanedioic acid (HY-W014787). Decanedioic acid is a straight-chain dicarboxylic acid. Dodecanedioic acid overcomes metabolic inflexibility in type 2 diabetes. Decanedioic acid prevents and reverses metabolic-associated liver disease and obesity. Decanedioic acid is associated with carnitine-acylcarnitine translocase deficiency and medium chain acyl-CoA dehydrogenase deficiency .

HY-W014787S1

Decanedioic acid-d16

Decanedioic acid-d₁₆ is the deuterium labeled Decanedioic acid (HY-W014787). Decanedioic acid is a straight-chain dicarboxylic acid. Dodecanedioic acid overcomes metabolic inflexibility in type 2 diabetes. Decanedioic acid prevents and reverses metabolic-associated liver disease and obesity. Decanedioic acid is associated with carnitine-acylcarnitine translocase deficiency and medium chain acyl-CoA dehydrogenase deficiency .

HY-W653970

5-Azacytidine-15N4
5-Azacytidine- ¹⁵N₄ is ¹³C and ¹⁵N labeled 5-Azacytidine. 5-Azacytidine (Azacitidine; 5-AzaC; Ladakamycin) is a nucleoside analogue of cytidine that specifically inhibits DNA methylation. 5-Azacytidine is incorporated into DNA to covalently trap DNA methyltransferases and contributes to reverse epigenetic changes. 5-Azacytidine induces cell autophagy .

HY-10574S

Rilpivirine-d6
Rilpivirine-d₆ is the deuterium labeled Rilpivirine. Rilpivirine (R278474) is a potent and specific diarylpyrimidine (DAPY) non-nucleoside reverse transcriptase inhibitor (NNRTI). Rilpivirine has high antiviral activity against wild-type HIV (EC₅₀=0.4 nM) and mutant viruses (EC₅₀=0.1-2.0 nM). Rilpivirine has a high genetic barrier to resistance development of HIV .

HY-B0116S

Stavudine-d4
Stavudine-d₄ is the deuterium labeled Stavudine. Stavudine (d4T) is an orally active nucleoside reverse transcriptase inhibitor (NRTI). Stavudine has activity against HIV-1 and HIV-2. Stavudine also inhibits the replication of mitochondrial DNA (mtDNA). Stavudine reduces NLRP3 inflammasome activation and modulates Amyloid-β autophagy. Stavudine induces apoptosis .

HY-137522AS1

Zidovudine Glucuronide-13C6
Zidovudine Glucuronide- ¹³C₆ (3'-Azido-3'-deoxythymidine β-D-glucuronide- ¹³C₆) is ¹³C labeled Zidovudine O-β-D-glucuronide. Zidovudine O-β-D-glucuronide (3'-Azido-3'-deoxythymidine β-D-glucuronide) sodium is the major metabolite of Zidovudine. Zidovudine is a nucleoside reverse transcriptase inhibitor (NRTI), widely used to treat HIV infection .

HY-10572BS

(Rac)-Efavirenz-d4

(Rac)-Efavirenz-d₄ is a labelled racemic Efavirenz. Efavirenz (DMP 266) is a potent inhibitor of the wild-type HIV-1 reverse transcriptase with a K_i of 2.93 nM and exhibits an IC₉₅ of 1.5 nM for the inhibition of HIV-1 replicative spread in cell culture . (Rac)-Efavirenz-d4 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-W765997

Didanosine-13C2,15N
Didanosine- ¹³C₂, ¹⁵N (2',3'-Dideoxyinosine- ¹³C₂, ¹⁵N; ddI- ¹³C₂, ¹⁵N) is the ¹³C- and ¹⁵N-labeled labeled Didanosine (HY-B0249). Didanosine (2',3'-Dideoxyinosine; ddI) is a a potent and orally active dideoxynucleoside analogue, and also is a potent nucleoside reverse transcriptase inhibitor. Didanosine shows antiretroviral activity for HIV .

HY-10574S1

Rilpivirine-13C6

Rilpivirine- ¹³C₆ (R278474- ¹³C₆) is ¹³C labeled Rilpivirine. Rilpivirine (R278474) is a potent and specific diarylpyrimidine (DAPY) non-nucleoside reverse transcriptase inhibitor (NNRTI). Rilpivirine has high antiviral activity against wild-type HIV (EC₅₀=0.4 nM) and mutant viruses (EC₅₀=0.1-2.0 nM). Rilpivirine has a high genetic barrier to resistance development of HIV .

HY-10572S

Efavirenz-d5

Efavirenz-d₅ (DMP 266-d₅) is the deuterium labeled Efavirenz. Efavirenz (DMP 266) is a potent inhibitor of the wild-type HIV-1 reverse transcriptase with a K_i of 2.93 nM and exhibits an IC₉₅ of 1.5 nM for the inhibition of HIV-1 replicative spread in cell culture . Efavirenz-d₅ is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-137522S

Zidovudine O-β-D-glucuronide-d3 sodium

Zidovudine O-β-D-glucuronide-d₃ (sodium) (3'-Azido-3'-deoxythymidine β-D-glucuronide-d₃ (sodium)) is a deuterium labeled Zidovudine O-β-D-glucuronide (sodium) (HY-137522). Zidovudine O-β-D-glucuronide (3'-Azido-3'-deoxythymidine β-D-glucuronide) sodium is the major metabolite of Zidovudine. Zidovudine is a nucleoside reverse transcriptase inhibitor (NRTI), widely used to treat HIV infection .

HY-167855S

1’-Epi Gemcitabine hydrochloride-13C,15N2

1’-Epi Gemcitabine hydrochloride- ¹³C, ¹⁵N₂ is the ¹³C- and ¹⁵N-labeled MRS4833 (HY-167855). MRS4833 (compound 15) is an orally active, potent, competitive P2Y14R antagonist with an of IC₅₀ of 5.92 nM for hP2Y14R and an IC₅₀ of 4.8 nM for mP2Y14R. MRS4833 reduces airway eosinophilia in a protease-mediated asthma model and reverses chronic neuropathic pain in a mouse CCI model .

HY-W251598S

Bicarbonate-13C sodium

Bicarbonate- ¹³C sodium is the ¹³C-labeled Sodium bicarbonate (HY-Y0756). Sodium bicarbonate is an inorganic salt that is neutral to slightly alkaline and easily decomposes when exposed to moisture in the air. Sodium bicarbonate can maintain the pH of the culture medium, thereby affecting the expression of inducible nitric oxide synthase (iNOS) and nitric oxide (NO) production in macrophages and reversing the acidosis of the tumor microenvironment. Sodium bicarbonate is widely used in the fields of food, medicine, cosmetics, etc. Its main uses include buffers, flavoring agents, disinfectants, pharmaceuticals, and proton gradient regulators. Sodium bicarbonate is also commonly used as an antacid to inhibit gastrointestinal diseases, neutralize gastric acid, and reduce gastric discomfort .

HY-W012382S

N-Acetyl-L-tyrosine-d3

N-Acetyl-L-tyrosine-d₃ is the deuterated form of N-Acetyl-L-tyrosine (HY-W012382). N-Acetyl-L-tyrosine is an orally active endogenous mitochondrial stress response regulator that can permeate the cell membrane by passive diffusion. N-Acetyl-L-tyrosine induces low-level reactive oxygen species (ROS) generation by transiently perturbing mitochondrial membrane potential, triggering reverse signaling to activate FoxO and Keap1 pathways. As a result, N-Acetyl-L-tyrosine enhances the expression of antioxidant enzyme genes, exerting anti-stress and cytoprotective effects. N-Acetyl-L-tyrosine can improve heat stress tolerance, inhibit tumor growth, and regulate energy metabolism. N-Acetyl-L-tyrosine can be used in the research of aging, metabolic diseases (such as diabetes), and cancer .

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