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  4. Sodium bicarbonate, for cell culture

Sodium bicarbonate, for cell culture  (Synonyms: Sodium hydrogen carbonate for cell culture; Soda bicarbonate for cell culture)

Cat. No.: HY-W251598C Purity: ≥99.0%
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Handling Instructions Technical Support

Sodium bicarbonate, for cell culture (Sodium hydrogen carbonate for cell culture; Soda bicarbonate for cell culture) is an inorganic salt that is neutral to slightly alkaline and easily decomposes when exposed to moisture in the air. Sodium bicarbonate, for cell culture can maintain the pH of the culture medium, thereby affecting the expression of inducible nitric oxide synthase (iNOS) and nitric oxide (NO) production in macrophages and reversing the acidosis of the tumor microenvironment. Sodium bicarbonate is widely used in the fields of food, medicine, cosmetics, etc. Its main uses include buffers, flavoring agents, disinfectants, pharmaceuticals, and proton gradient regulators. Sodium bicarbonate is also commonly used as an antacid to inhibit gastrointestinal diseases, neutralize gastric acid, and reduce gastric discomfort.

For research use only. We do not sell to patients.

Sodium bicarbonate, for cell culture Chemical Structure

Sodium bicarbonate, for cell culture Chemical Structure

CAS No. : 144-55-8

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Based on 1 publication(s) in Google Scholar

Other Forms of Sodium bicarbonate, for cell culture:

Sodium bicarbonate, for cell culture Related Antibodies

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  • Purity & Documentation

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  • Customer Review

Description

Sodium bicarbonate, for cell culture (Sodium hydrogen carbonate for cell culture; Soda bicarbonate for cell culture) is an inorganic salt that is neutral to slightly alkaline and easily decomposes when exposed to moisture in the air. Sodium bicarbonate, for cell culture can maintain the pH of the culture medium, thereby affecting the expression of inducible nitric oxide synthase (iNOS) and nitric oxide (NO) production in macrophages and reversing the acidosis of the tumor microenvironment. Sodium bicarbonate is widely used in the fields of food, medicine, cosmetics, etc. Its main uses include buffers, flavoring agents, disinfectants, pharmaceuticals, and proton gradient regulators. Sodium bicarbonate is also commonly used as an antacid to inhibit gastrointestinal diseases, neutralize gastric acid, and reduce gastric discomfort[1][2][3][4][5][6].

In Vitro

Sodium bicarbonate (0.06-0.12 M; 48 h) significantly inhibits the growth of bacteria such as Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, and Saccharomyces cerevisiae[2].
Sodium bicarbonate (14-44 mM; 20 h) enhances iNOS protein expression and NO production in LPS/IFNγ-stimulated J774.1/JA-4 and RAW264.7 macrophages in a concentration-dependent manner by regulating intracellular and extracellular pH. At 44 mM, NO production increased by 2.7 times[3].
Sodium bicarbonate (0.3 M; 6 d) inhibits breast cancer cell migration and enhances the toxicity of doxorubicin to triple-negative breast cancer cells by increasing the pH of the tumor microenvironment to 7.39, reducing cell viability to 12%[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Sodium bicarbonate, for cell culture Related Antibodies
In Vivo

Sodium bicarbonate (200 mM; add in water, oral daily; 30-60 days) significantly reduces the number of lung, intestinal and diaphragmatic metastases and improves mouse survival in a severe combined immunodeficient (SCID) beige mice MDA-MB-231 adenocarcinoma model[4][5].
Sodium bicarbonate (0.25 g/kg; oral gavage; single dose) reduces alcohol intake by 20% and significantly reduces alcohol preference by 20% in mice[6].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

84.01

Formula

NaHCO3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=[C]OO[NaH]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

RT, protect from light

In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (1190.33 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 11.9033 mL 59.5167 mL 119.0334 mL
5 mM 2.3807 mL 11.9033 mL 23.8067 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: ≥99.0%

SDS (393 KB)

COA (247 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 11.9033 mL 59.5167 mL 119.0334 mL 297.5836 mL
5 mM 2.3807 mL 11.9033 mL 23.8067 mL 59.5167 mL
10 mM 1.1903 mL 5.9517 mL 11.9033 mL 29.7584 mL
15 mM 0.7936 mL 3.9678 mL 7.9356 mL 19.8389 mL
20 mM 0.5952 mL 2.9758 mL 5.9517 mL 14.8792 mL
25 mM 0.4761 mL 2.3807 mL 4.7613 mL 11.9033 mL
30 mM 0.3968 mL 1.9839 mL 3.9678 mL 9.9195 mL
40 mM 0.2976 mL 1.4879 mL 2.9758 mL 7.4396 mL
50 mM 0.2381 mL 1.1903 mL 2.3807 mL 5.9517 mL
60 mM 0.1984 mL 0.9919 mL 1.9839 mL 4.9597 mL
80 mM 0.1488 mL 0.7440 mL 1.4879 mL 3.7198 mL
100 mM 0.1190 mL 0.5952 mL 1.1903 mL 2.9758 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Sodium bicarbonate, for cell culture Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sodium bicarbonate, for cell culture144-55-8Sodium hydrogen carbonate for cell culture Soda bicarbonate for cell cultureBacterialInhibitorinhibitorinhibit

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