2. Anti-infection
  3. HIV Reverse Transcriptase
  4. EFdA-TP tetralithium

EFdA-TP tetralithium is a potent nucleoside reverse transcriptase (RT) inhibitor. EFdA-TP tetralithium inhibits RT-catalyzed DNA synthesis as an effective immediate or delayed chain terminator (ICT or DCT). EFdA-TP tetralithium inhibits HIV-1 RT with multiple mechanisms.

For research use only. We do not sell to patients.

EFdA-TP tetralithium Chemical Structure

EFdA-TP tetralithium Chemical Structure

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1 mg In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of EFdA-TP tetralithium:

EFdA-TP tetralithium Related Antibodies

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Description

EFdA-TP tetralithium is a potent nucleoside reverse transcriptase (RT) inhibitor. EFdA-TP tetralithium inhibits RT-catalyzed DNA synthesis as an effective immediate or delayed chain terminator (ICT or DCT). EFdA-TP tetralithium inhibits HIV-1 RT with multiple mechanisms[1].

In Vitro

EFdA-TP (0.05-10 μM; for 15 min) tetralithium inhibits RT-catalyzed DNA synthesis as an ICT or DCT[1].
EFdA-TP tetralithium can block RT as a translocation-defective RT inhibitor that dramatically slows DNA synthesis, acting as a de facto immediate chain terminator[1].
EFdA-TP tetralithium can function as a delayed chain terminator, allowing incorporation of an additional dNTP before blocking DNA synthesis[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

EFdA-TP tetralithium Related Antibodies
Molecular Weight

556.93

Formula

C12H11FLi4N5O12P3
Appearance

Solid

Color

White to off-white

SMILES

O=[P](O[P](O[P](O[Li])(O[Li])=O)(O[Li])=O)(O[Li])OC[C@]1(O[C@@](C[C@@H]1O)([H])N2C3=NC(F)=NC(N)=C3N=C2)C#C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

H2O : ≥ 100 mg/mL (179.56 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7956 mL 8.9778 mL 17.9556 mL
5 mM 0.3591 mL 1.7956 mL 3.5911 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.7956 mL 8.9778 mL 17.9556 mL 44.8889 mL
5 mM 0.3591 mL 1.7956 mL 3.5911 mL 8.9778 mL
10 mM 0.1796 mL 0.8978 mL 1.7956 mL 4.4889 mL
15 mM 0.1197 mL 0.5985 mL 1.1970 mL 2.9926 mL
20 mM 0.0898 mL 0.4489 mL 0.8978 mL 2.2444 mL
25 mM 0.0718 mL 0.3591 mL 0.7182 mL 1.7956 mL
30 mM 0.0599 mL 0.2993 mL 0.5985 mL 1.4963 mL
40 mM 0.0449 mL 0.2244 mL 0.4489 mL 1.1222 mL
50 mM 0.0359 mL 0.1796 mL 0.3591 mL 0.8978 mL
60 mM 0.0299 mL 0.1496 mL 0.2993 mL 0.7481 mL
80 mM 0.0224 mL 0.1122 mL 0.2244 mL 0.5611 mL
100 mM 0.0180 mL 0.0898 mL 0.1796 mL 0.4489 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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EFdA-TP tetralithium Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EFdA-TP tetralithiumHIVReverse TranscriptaseHuman immunodeficiency virusInhibitorinhibitorinhibit

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