2. Autophagy Apoptosis
  3. Autophagy Ferroptosis
  4. PD146176

PD146176 (NSC168807), a 15-Lipoxygenase (15-LO) inhibitor, inhibits rabbit reticulocyte 15-LO (Ki=197 nM, IC50=0.54 μM). PD146176 reverses cognitive impairment, brain amyloidosis, and tau pathology by stimulating autophagy in aged triple transgenic mice.

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PD146176 Chemical Structure

PD146176 Chemical Structure

CAS No. : 4079-26-9

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Solution
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PD146176 Related Antibodies

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Description

PD146176 (NSC168807), a 15-Lipoxygenase (15-LO) inhibitor, inhibits rabbit reticulocyte 15-LO (Ki=197 nM, IC50=0.54 μM). PD146176 reverses cognitive impairment, brain amyloidosis, and tau pathology by stimulating autophagy in aged triple transgenic mice[1][2][3].

IC50 & Target

Ki: 197 nM (Rabbit reticulocyte 15-LO)[1]
IC50: 0.54 μM[2]
Cellular Effect
Cell Line Type Value Description References
HEK293 IC50
810 nM
Compound: PD-146176
Inhibition of human 12/15-LOX expressed in HEK293 cells after 30 mins by microplate reader analysis
Inhibition of human 12/15-LOX expressed in HEK293 cells after 30 mins by microplate reader analysis
[PMID: 26899595]
In Vitro

In intact IC21 cells transfected with human 15-LO, PD146176 inhibits 13-HODE production with an IC50 of 0.81 μM[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PD146176 Related Antibodies
In Vivo

PD146176 (80 mg/kg; Chowing; 12 weeks) reverses cognitive impairment, brain amyloidosis, and Tau pathology by stimulating autophagy in aged triple transgenic mice[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Triple transgenic (3xTg) mice[3]
Dosage: 80 mg/kg
Administration: Chowing; 12 weeks
Result: Significantly lower amyloid beta levels and deposition, less tau neuropathology, increased synaptic integrity, and autophagy activation.
Molecular Weight

237.32

Formula

C15H11NS
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

C1(N2)=C(CSC3=CC=CC=C31)C4=C2C=CC=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation

Purity: ≥99.0%

SDS (251 KB)

COA (255 KB)

Handling Instructions (2659 KB)
References
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PD146176 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PD1461764079-26-9NSC168807PD 146176PD-146176NSC 168807NSC-168807AutophagyFerroptosisIC21cellstripletransgenicmicerabbitreticulocytecognitiveimpairmentbrainamyloidosistaupathologyInhibitorinhibitorinhibit

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