2. GPCR/G Protein Neuronal Signaling
  3. Opioid Receptor
  4. BU72

BU72 is a highly potent and long-acting agonist of μ and κ opioid receptors, and also has a partial agonist effect on δ opioid receptors (EC50 values are 0.054, 0.033, and 0.58 nM, respectively). BU72 has a strong and long-lasting analgesic effect, which is mainly mediated by μ opioid receptors. BU72 has a long-lasting activity and can partially reverse the analgesic effect of morphine. BU72 can be used in the study of opioid dependence.

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BU72 Chemical Structure

BU72 Chemical Structure

CAS No. : 173265-76-4

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BU72 Related Antibodies

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μ Opioid Receptor/MOR κ Opioid Receptor/KOR δ Opioid Receptor/DOR NOP Receptor/ORL1

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Description

BU72 is a highly potent and long-acting agonist of μ and κ opioid receptors, and also has a partial agonist effect on δ opioid receptors (EC50 values are 0.054, 0.033, and 0.58 nM, respectively). BU72 has a strong and long-lasting analgesic effect, which is mainly mediated by μ opioid receptors. BU72 has a long-lasting activity and can partially reverse the analgesic effect of morphine. BU72 can be used in the study of opioid dependence[1].

IC50 & Target[1]

μ Opioid Receptor/MOR

0.054 nM (EC50)

κ Opioid Receptor/KOR

0.033 nM (EC50)

δ Opioid Receptor/DOR

0.58 nM (EC50)

Molecular Weight

428.57

Formula

C28H32N2O2
CAS No.
SMILES

CO[C@@]12[C@](N[C@@H]3C4=CC=CC=C4)([H])[C@@](C5=CC(O)=CC=C5C[C@@]6([H])N7C)(CC7)C6(C=C2)CC13C
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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BU72 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BU72173265-76-4BU 72BU-72Opioid Receptormu-opioid receptorNIH miceICR miceMacaca mulattaCHO cellsInhibitorinhibitorinhibit

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