2. Cell Cycle/DNA Damage Epigenetics Apoptosis
  3. HDAC Apoptosis
  4. Chlopynostat

Chlopynostat (Compound 6c) is a HDAC1 inhibitor with a IC50 value of 67 nM. Chlopynostat reverses STAT4/p66Shc defects by inhibiting HDAC1-induced < b>Apoptosis.

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Chlopynostat Chemical Structure

Chlopynostat Chemical Structure

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Based on 1 publication(s) in Google Scholar

Chlopynostat Related Antibodies

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View All HDAC Isoform Specific Products:

View All Isoforms
HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

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Description

Chlopynostat (Compound 6c) is a HDAC1 inhibitor with a IC50 value of 67 nM. Chlopynostat reverses STAT4/p66Shc defects by inhibiting HDAC1-induced < b>Apoptosis[1].

IC50 & Target

HDAC1

67 nM (IC50)

Molecular Weight

404.85

Formula

C22H17ClN4O2
Appearance

Solid

Color

White to off-white

SMILES

O=C1N(CC2=CC=C(C(NC3=CC=CC=C3N)=O)C=C2)C=NC4=CC(Cl)=CC=C41
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (123.50 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4701 mL 12.3503 mL 24.7005 mL
5 mM 0.4940 mL 2.4701 mL 4.9401 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4701 mL 12.3503 mL 24.7005 mL 61.7513 mL
5 mM 0.4940 mL 2.4701 mL 4.9401 mL 12.3503 mL
10 mM 0.2470 mL 1.2350 mL 2.4701 mL 6.1751 mL
15 mM 0.1647 mL 0.8234 mL 1.6467 mL 4.1168 mL
20 mM 0.1235 mL 0.6175 mL 1.2350 mL 3.0876 mL
25 mM 0.0988 mL 0.4940 mL 0.9880 mL 2.4701 mL
30 mM 0.0823 mL 0.4117 mL 0.8234 mL 2.0584 mL
40 mM 0.0618 mL 0.3088 mL 0.6175 mL 1.5438 mL
50 mM 0.0494 mL 0.2470 mL 0.4940 mL 1.2350 mL
60 mM 0.0412 mL 0.2058 mL 0.4117 mL 1.0292 mL
80 mM 0.0309 mL 0.1544 mL 0.3088 mL 0.7719 mL
100 mM 0.0247 mL 0.1235 mL 0.2470 mL 0.6175 mL
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Chlopynostat Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ChlopynostatHDACApoptosisHistone deacetylasesHDAC1InhibitorChronic lymphocytic leukemiainhibitorinhibit

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