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Results for "

ICP/BP

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (2) Acyltransferase (1) ADC Cytotoxin (1) Adrenergic Receptor (1) Androgen Receptor (1) Angiotensin-converting Enzyme (ACE) (1) Antibiotic (2) Apoptosis (16) ATM/ATR (2) Autophagy (21) Bacterial (11) Biochemical Assay Reagents (14) Btk (1) c-Met/HGFR (1) Calcium Channel (16) Casein Kinase (1) CDK (2) CRFR (3) Cyclophilin (1) Dengue Virus (1) Deubiquitinase (1) DNA/RNA Synthesis (7) Dopamine Receptor (3) Drug Derivative (1) E3 Ligase Ligand-Linker Conjugates (1) Endogenous Metabolite (1) FAP (4) FGFR (1) Fluorescent Dye (42) Hedgehog (2) Hexokinase (1) HSP (1) HSV (2) IFNAR (1) Insulin Receptor (3) Integrin (4) Interleukin Related (2) Isotope-Labeled Compounds (5) Ligands for E3 Ligase (1) Ligands for Target Protein for PROTAC (2) LPL Receptor (1) MDM-2/p53 (2) Microtubule/Tubulin (1) Mitophagy (5) mTOR (4) nAChR (1) Neprilysin (1) Organoid (4) p38 MAPK (4) p97 (1) PDGFR (1) Phosphatase (1) Phosphodiesterase (PDE) (2) PI3K (1) Pim (1) PROTACs (3) Pyroptosis (1) Radionuclide-Drug Conjugates (RDCs) (1) Reactive Oxygen Species (1) SARS-CoV (1) Small Interfering RNA (siRNA) (59) Sodium Channel (7) STAT (4) STING (3) Topoisomerase (1) VEGFR (2) Virus Protease (1)
By Research Areas:	Cancer (82) Cardiovascular Disease (22) Endocrinology (1) Infection (12) Inflammation/Immunology (14) Metabolic Disease (9) Neurological Disease (19)
Click Chemistry:	TCO (1) Labeling and Fluorescence Imaging (1) Alkynes (4)
Oligonucleotides:	Aptamers (1) Rat Pre-designed siRNA Sets (11) Mouse Pre-designed siRNA Sets (11) Human Pre-designed siRNA Sets (37) Antisense Oligonucleotides (2) siRNAs (59)

225

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

MCE Kits

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-129390

Orelabrutinib 2 Publications Verification ICP-022	Btk	Cancer
Orelabrutinib (ICP-022) is a potent, orally active, and irreversible Bruton's tyrosine kinase (BTK) inhibitor with potential antineoplastic activity. Orelabrutinib prevents both the activation of the B-cell antigen receptor (BCR) signaling pathway and BTK-mediated activation of downstream survival pathways, inhibiting the growth of malignant B-cells that overexpress BTK .

HY-132817

Gunagratinib ICP-192	FGFR	Cancer
Gunagratinib (ICP-192) is a low toxicity and orally active pan-FGFR (fibroblast growth factor receptors) inhibitor that potently and selectively inhibits FGFR activities irreversibly by covalent binding. Gunagratinib can be used for the research of cancer . Gunagratinib is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups .

HY-P10131

3BP-3940	Radionuclide-Drug Conjugates (RDCs) FAP	Cancer
3BP-3940 is a highly potent and selective peptide inhibitor of FAP that targets cancer-associated fibroblasts (CAFs) in the tumor microenvironment. 3BP-3940 can be labeled with radionuclides (such as Ga-68) for precise tumor imaging or Lu-177 for the development of targeted anticancer technologies. 3BP-3940 accumulates in tumor lesions and can be used to diagnose and inhibit various solid cancers and CAFs-related diseases .

HY-P3441A

3BP-4089 TFA	FAP	Cancer
3BP-4089 TFA is a highly potent fibroblast activation protein (FAP)-targeting peptide for theranostics. 3BP-4089 TFA is often coupled with radionuclides for tumor diagnosis and research .

HY-156110

IGF2BP1-IN-1	Insulin Receptor	Cancer
IGF2BP1-IN-1 (Compound A11) is a *IGF2BP1* inhibitor and inhibits downstream signaling. IGF2BP1-IN-1 binds to IGF2BP1 protein with a K_D value of 2.88 nM. IGF2BP1-IN-1 inhibits cancer cells proliferation (IC₅₀: 9 nM for A549 cell, 34 nM for HCT116). IGF2BP1-IN-1 induces cancer cell apoptosis. GF2BP1-IN-1 inhibits tumor growth in A549 xenograft mouse model .

HY-125151

BP-1-108	STAT Apoptosis	Cancer
BP-1-108 is a selective inhibitor of STAT5 (K_i=8.3 μM) with anticancer activity. BP-1-108 induces apoptosis of leukemia cells by inhibiting the phosphorylation of STAT5. BP-1-108 can be used in the study of acute myeloid leukemia and prostate cancer .

HY-P3441

3BP-4089	FAP	Cancer
3BP-4089 is a highly potent fibroblast activation protein (FAP)-targeting peptide for theranostics. 3BP-4089 is often coupled with radionuclides for tumor diagnosis and research .

HY-176440

BP-198	Virus Protease SARS-CoV PROTACs	Infection
BP-198 is an Mpro PROTAC degrader. BP-198 promotes the ubiquitination and degradation of Mpro. BP-198 has antiviral effects against SARS-CoV-2 (IC50: 11.8 μM) and has stronger activity against drug-resistant viruses. (Pink: target protein ligand (HY-176442); blue: E3 ligase ligand (HY-176441); black: linker (HY-W457968); E3 ligase-linker conjugate (HY-176443)) .

HY-109743

BP14979	Dopamine Receptor	Neurological Disease
BP14979 is a dopamine D3 receptor agonist with activity in the study of neurological diseases. BP14979 can be used to develop ligands with higher selectivity and affinity for D3 receptors. The structural characteristics of BP14979 make it potential in modulating the efficacy of D3 receptors. The design of BP14979 is based on the difference in efficacy with D3R selective antagonists, providing opportunities for optimizing new drug development .

HY-136797

BP13944	Dengue Virus	Infection
BP13944 is a potential small molecule inhibitor discovered by high-throughput screening. It can effectively inhibit the expression of dengue virus (DENV) replicons with an EC50 value of 1.03±0.09 μM. BP13944 can inhibit the replication or viral RNA synthesis of all four serotypes of DENV, but is ineffective against Japanese encephalitis virus. BP13944 may target the DENV NS3 protease, and the E66G amino acid substitution in the NS3 protease region will cause the virus to become resistant to BP13944. BP13944 has no obvious cytotoxicity. As there is currently no effective dengue vaccine and treatment, BP13944, as an effective small molecule inhibitor, may become a potential agent for the treatment of dengue in the future.

HY-114085

BP 897	Dopamine Receptor	Neurological Disease
BP 897 is a potent and partial dopamine D3 receptor agonist and a weak D2 receptor antagonist. BP 897 displays a high affinity at the dopamine D3 receptor (K_i=0.92 nM) and a 70 times lower affinity at the D2 receptor (K_i=61 nM) .

HY-106660

BP 897 hydrochloride	Dopamine Receptor	Neurological Disease
BP 897 hydrochloride is a potent and partial dopamine D3 receptor agonist and a weak D2 receptor antagonist. BP 897 hydrochloride displays a high affinity at the dopamine D3 receptor (K_i=0.92 nM) and a 70 times lower affinity at the D2 receptor (K_i=61 nM) .

HY-100493

BP-1-102 10+ Cited Publications	STAT	Cancer
BP-1-102 is an orally available, small-molecule inhibitor of transcription factor Stat3, with an IC₅₀ of 6.8 μM.

HY-D1418

CP-BP-SFAC	Fluorescent Dye	Others
CP-BP-SFAC is a luminogenic molecule. CP-BP-SFAC exhibits strong sky-blue delayed fluorescence in neat films .

HY-W668749

3BP-3580	FAP	Cancer
3BP-3580 is a fibroblast activation protein (FAP) inhibitor (pIC₅₀: 8.6), and can be used for cancer research .

HY-P6010

αvβ6-BP	Integrin	Cancer
αvβ6-BP is a selective αvβ6 binding peptide, and can be used for molecular imaging .

HY-D1417

P-BP-SFAC	Fluorescent Dye	Others
P-BP-SFAC is a fluorescence molecule. P-BP-SFAC exhibits an apparent absorption band with a peak at about 377 nm, indicative of a stronger ICT effect .

HY-110087

4BP-TQS	nAChR	Neurological Disease
4BP-TQS is a potent allosteric agonist of α7 nAChR. 4BP-TQS activates nAChRs via an allosteric transmembrane site .

HY-P6009

Cys-αvβ6-BP	Integrin	Cancer
Cys-αvβ6-BP is a cysteine-terminated αvβ6 binding peptide .

HY-170873

G3BP1/2-Targeting ligand-1	Ligands for Target Protein for PROTAC	Cancer
G3BP1/2-Targeting ligand-1 is the ligand for *G3BP1/2* that can be used as target protein ligand for synthesis of G3BP1/2 PROTAC degrader PT-129 (HY-170872) .

HY-176471

IGF2BP3-IN-1	Insulin Receptor	Cancer
IGF2BP3-IN-1 is an *IGF2BP3* (a RNA binding protein) inhibitor (IC₅₀: > 50 μM), and can be used for cancer research .

HY-P6010A

αvβ6-BP TFA	Integrin	Cancer
αvβ6-BP TFA is a selective αvβ6 binding peptide, and can be used for research of molecular imaging .

HY-D1419

mCP-BP-SFAC	Fluorescent Dye	Others
mCP-BP-SFAC is a luminogenic molecule. mCP-BP-SFAC exhibits strong sky-blue delayed fluorescence in neat films, with photoluminescence (PL) peaks at ~483 nm and delayed fluorescence lifetimes of 5.4 to 5.7 μs .

HY-D1420

TCP-BP-SFAC	Fluorescent Dye	Others
TCP-BP-SFAC is a luminogenic molecule. TCP-BP-SFAC exhibits strong sky-blue delayed fluorescence in neat films, with photoluminescence (PL) peaks at ~483 nm and delayed fluorescence lifetimes of 5.4 to 5.7 μs .

HY-P6009A

Cys-αvβ6-BP TFA	Integrin	Cancer
Cys-αvβ6-BP TFA is a cysteine-terminated αvβ6 binding peptide .

HY-157850

BP-M345	Microtubule/Tubulin	Cancer
BP-M345 (compound 5) is a potent, cancer cell-targeting antiproliferative agent that exhibits low toxicity to non-tumor cells. BP-M345 inhibits cancer cell proliferation with a GI₅₀ value ranging from 0.17 to 0.45 μM .

HY-D2754

BP Light 550 carboxylic acid	Fluorescent Dye	Others
BP Light 550 acid is a vibrant orange-to-red fluorochrome with better performance t han other rhodamine derivatives, including BP Fluor 555, TRITC, and Cy3 dye for fluorescent applications. The high water solubility of BP Light Fluors means that a high dye-to-protein ratio can be attained without causing precipitation of the conjugates.

HY-115997

PROTAC HSP90 degrader BP3	PROTACs HSP	Cancer
PROTAC HSP90 degrader BP3 is a potent and selective degradation of HSP90 in a CRBN-dependent fashion. PROTAC HSP90 degrader BP3 has a certain degradation effect on HSP90 protein in MCF-7 cells (DC₅₀=0.99 μM). PROTAC HSP90 degrader BP3 inhibits the growth of breast cancer cell . PROTAC HSP90 degrader BP3 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-W800699

BP Fluor 430 DBCO	Fluorescent Dye	Others
BP Fluor 430 DBCO reacts with azides via a copper-free click chemistry reaction to form a stable triazole and does not require a Cu-catalyst or elevated temperatures. In applications where the presence of copper is a concern, BP Fluor 430 DBCO is an ideal alternative to copper requiring fluorescent alkynes. BP Fluor 430 is a bright, photostable, green-fluorescent probe optimally excited near its absorption maximum at 432 nm. Its emission peak at 539 nm is pH independent over a wide pH range. BP Fluor DBCO reagent is not suitable for staining intracellular components of fixed and permeabilized cells due to high backgrounds.

HY-U00035

MGB-BP-3	Bacterial	Infection
MGB-BP-3 is an antibiotic that has been shown to be active against a broad range of important multi-resistant Gram-positive pathogens.

HY-W800704

BP Fluor 594 alkyne	Fluorescent Dye	Others
BP Fluor 594 alkyne is a bright, red-fluorescent alkyne-activated probe routinely used for imaging of azide-containing biomolecules. BP Fluor 594 alkyne reacts with azides via a copper-catalyzed click reaction (CuAAC) to form a stable triazole linker.

HY-W800698

BP Fluor 430 alkyne	Fluorescent Dye	Others
BP Fluor 430 Alkyne is a green-fluorescent alkyne-activated probe routinely used for imaging of moderate to high abundance azide-containing biomolecules. BP Fluor 430 Alkyne reacts with azides via a copper-catalyzed click reaction (CuAAC) to form a stable triazole linker. BP Fluor 430 is a bright, photostable, green-fluorescent probe optimally excited near 430 nm. This probe is water-soluble and its fluorescence is pH independent over a wide pH range.

HY-D2745

BP Fluor 594 NHS ester	Fluorescent Dye	Others
BP Fluor 594 NHS ester is the most popular tool for modifying proteins or antibodies through the primary amines (Lys), amine-modified oligonucleotides, and other amine-containing biomolecules with BP Fluor 594 label. The labeling occurs most efficiently at pH 7-9 and forms a stable, covalent amide bond. BP Fluor 594 dye can be used for proteins labeling at high molar ratios without significant self-quenching, enabling brighter conjugates and more sensitive detection. BP Fluor 594 is bright, water-soluble, and pH-insensitive from pH 4 to pH 10 red-fluorescent dye with absorption and emission maxima at 590 and 617 nm, respectively. It can be used with the 561 nm and 594 nm laser lines. BP Fluor 594 dye conjugated to a variety of antibodies, peptides, proteins, tracers, and amplification substrates often used for generation of stable signal in imaging and flow cytometry.

HY-D2738

BP Fluor 532 NHS ester	Fluorescent Dye	Others
BP Fluor 532 NHS ester is an amine reactive, yellow-emitting dye routinely used to label proteins or antibodies through primary amines (Lys), amine-modified oligonucleotides, and other amine-containing biomolecules. The labeling occurs most efficiently at pH 7-9 and forms a stable, covalent amide bond. BP Fluor 532 is a bright yellow-fluorescent dye with pH insensitive emission from pH 4 to pH 10. The excitation of BP Fluor 532 is ideally suited for the frequency-doubled Nd:YAG laser line. BP Fluor 532 can be conjugated to a variety of antibodies, peptides, proteins, tracers, and amplification substrates, and is often used for the generation of stable signals in imaging and flow cytometry.

HY-D2755

BP Light 650 carboxylic acid	Fluorescent Dye	Others
BP Light 650 carboxylic acid is an vibrant far-red fluorochrome with comparable or improved performance over other dyes, including BP Fluor 647 and Cy5 dye, for fluorescent applications. It is used to label antibodies and other proteins as molecular probes for cellular imaging and other fluorescence detection methods application.

HY-D2771

BP Fluor 405 NHS ester	Fluorescent Dye	Others
BP Fluor 405 NHS Ester is a water-soluble, blue-fluorescent dye that is often used in multi-color applications, including flow cytometry and super-resolution microscopy using STORM. Its excitation is ideally suited for the 407 nm spectral line of the krypton laser or the 408 nm violet laser diode. BP Fluor 405 conjugates are pH-insensitive from pH 4 to pH 10. The NHS ester (or succinimidyl ester) is the most popular amine reactive group for labeling with the primary amines of proteins (Lys), amine-modified oligonucleotides, and other amine-containing molecules. Proteins can be labeled with BP Fluor 405 NHS Ester at high molar ratios without significant self-quenching, leading to brighter conjugates and more sensitive detection. BP Fluor 405 conjugates can also be used for the detection of abundance targets.

HY-W800701

BP Fluor 546 DBCO	Biochemical Assay Reagents	Others
BP Fluor 546 DBCO is an azide-reactive probe that can be used for imaging azide-tagged biomolecules via a copper-free click reaction. The DBCO moiety reacts with azides to form a stable triazole and does not require a Cu-catalyst or elevated temperatures. In applications where the presence of copper is a concern, BP Fluor 546 DBCO is an ideal alternative to copper-requiring fluorescent alkynes. BP Fluor 546 is a water-soluble, pH-insensitive (from pH 4-10), orange-fluorescent dye with absorption and emission maxima at 554 and 570 nm, respectively. It can be used with the 488 nm and 532 nm laser lines. BP Fluor 546 dye conjugates to a variety of antibodies, peptides, proteins, tracers, and amplification substrates, which are often used for generating stable signals in imaging and flow cytometry.

HY-W800838

BP Fluor 488 Tetrazine	Fluorescent Dye	Cancer
BP Fluor 488 Tetrazine is a bright, green-fluorescent probe used for detection TCO-tagged biopolymers. BP Fluor 488 Tetrazine demonstrates exceptionally fast cycloaddition kinetics (up to 30 000 M-1 s-1) with trans-cyclooctenes (TCO) as the dienophile, the fastest kinetics ever reported for any bioorthogonal reaction. In applications such as in vivo cancer imaging or pre?targeted cell labeling studies where rapid reaction kinetics is a must BP Fluor 488 Tetrazine probe would of great value.

HY-D2751

BP Fluor 488 cadaverine	Fluorescent Dye	Others
BP Fluor 488 Cadaverine is a carboxyl/carbonyl reactive building block used widely to modify carboxylic groups in the presence of activators (e.g. EDC or DCC) or activated esters (e.g. NHS esters) through a stable amide bond. BP Fluor 488 dye has an excitation peak at 499 nm and an emission peak at 520 nm. The conjugates are widely used in microscopy, flow cytometry, and other applications. BP Fluor 488 is a pure 5-sulfonated rhodamine molecule and it eliminates the lot-to-lot variation caused by two isomers ratio differences.

HY-RS26345

Lgals3bp Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Lgals3bp Rat Pre-designed siRNA Set A contains three designed siRNAs for Lgals3bp gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Lgals3bp Rat Pre-designed siRNA Set A Lgals3bp Rat Pre-designed siRNA Set A

HY-RS21093

Arl2bp Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Arl2bp Mouse Pre-designed siRNA Set A contains three designed siRNAs for Arl2bp gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Arl2bp Mouse Pre-designed siRNA Set A Arl2bp Mouse Pre-designed siRNA Set A

HY-RS21866

Hsf2bp Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Hsf2bp Mouse Pre-designed siRNA Set A contains three designed siRNAs for Hsf2bp gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Hsf2bp Mouse Pre-designed siRNA Set A Hsf2bp Mouse Pre-designed siRNA Set A

HY-RS00986

ARL2BP Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
ARL2BP Human Pre-designed siRNA Set A contains three designed siRNAs for ARL2BP gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

ARL2BP Human Pre-designed siRNA Set A ARL2BP Human Pre-designed siRNA Set A

HY-RS14095

SYNJ2BP Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SYNJ2BP Human Pre-designed siRNA Set A contains three designed siRNAs for SYNJ2BP gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SYNJ2BP Human Pre-designed siRNA Set A SYNJ2BP Human Pre-designed siRNA Set A

HY-RS12441

SAP30BP Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SAP30BP Human Pre-designed siRNA Set A contains three designed siRNAs for SAP30BP gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SAP30BP Human Pre-designed siRNA Set A SAP30BP Human Pre-designed siRNA Set A

HY-RS28383

Hsf2bp Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Hsf2bp Rat Pre-designed siRNA Set A contains three designed siRNAs for Hsf2bp gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Hsf2bp Rat Pre-designed siRNA Set A Hsf2bp Rat Pre-designed siRNA Set A

HY-RS27611

Arl2bp Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Arl2bp Rat Pre-designed siRNA Set A contains three designed siRNAs for Arl2bp gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Arl2bp Rat Pre-designed siRNA Set A Arl2bp Rat Pre-designed siRNA Set A

HY-RS18310

Il18bp Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Il18bp Mouse Pre-designed siRNA Set A contains three designed siRNAs for Il18bp gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Il18bp Mouse Pre-designed siRNA Set A Il18bp Mouse Pre-designed siRNA Set A

HY-RS07605

LGALS3BP Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
LGALS3BP Human Pre-designed siRNA Set A contains three designed siRNAs for LGALS3BP gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

LGALS3BP Human Pre-designed siRNA Set A LGALS3BP Human Pre-designed siRNA Set A

HY-RS06709

IL18BP Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
IL18BP Human Pre-designed siRNA Set A contains three designed siRNAs for IL18BP gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

IL18BP Human Pre-designed siRNA Set A IL18BP Human Pre-designed siRNA Set A

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-121254

GERI-BP002-A	Structural Classification Natural Products Microorganisms Source classification	Acyltransferase
GERI-BP002-A is an inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT) produced by Aspergillus fumigatus F93, which can be used in cancer research .

HY-N0848

Epibrassinolide 10+ Cited Publications 24-Epibrassinolide; B1105; BP55	Structural Classification Natural Products Classification of Application Fields Source classification Plants Biological Pesticide Research Agricultural Research Brassinolide Phytohormone Brassicaceae Brassica campestris L. Disease Research Fields Cancer	Apoptosis
Epibrassinolide (24-Epibrassinolide) is a ubiquitously occurring plant growth hormone which shows great potential to alleviate heavy metals and pesticide stress in plants . Epibrassinolide is a potential apoptotic inducer in various cancer cells without affecting the non-tumor cell growth .

HY-N0252

Catharanthine (+)-3,4-Didehydrocoronaridine	Apocynaceae Cardiovascular Disease Alkaloids Structural Classification Classification of Application Fields Source classification Plants Disease Research Fields Indole Alkaloids Catharanthus roseus (L.) G. Don	Calcium Channel
Catharanthine ((+)-3,4-Didehydrocoronaridine), a constituent of anticancer vinca alkaloids, inhibits voltage-operated L-type Ca ²⁺ channel (VOCC). Catharanthine has IC₅₀s of 220 μM and 8 μM for VOCC currents in cardiomyocytes and vascular smooth muscle cells (VSMCs), respectively. Catharanthine lowers blood pressure (BP), heart rate (HR). Catharanthine has anti-cancer activity .

HY-N0252A

Catharanthine Tartrate (+)-3,4-Didehydrocoronaridine Tartrate	Apocynaceae Cardiovascular Disease Alkaloids Structural Classification Classification of Application Fields Source classification Plants Disease Research Fields Indole Alkaloids Catharanthus roseus (L.) G. Don Cancer	Calcium Channel
Catharanthine ((+)-3,4-Didehydrocoronaridine) Tartrate, a constituent of anticancer vinca alkaloids, inhibits voltage-operated L-type Ca ²⁺ channel (VOCC). Catharanthine Tartrate has IC₅₀s of 220 μM and 8 μM for VOCC currents in cardiomyocytes and vascular smooth muscle cells (VSMCs), respectively. Catharanthine Tartrate lowers blood pressure (BP), heart rate (HR). Catharanthine Tartrate has anti-cancer activity .

HY-N6954

Garcinone C 2 Publications Verification	Structural Classification other families Xanthones Classification of Application Fields Garcinia oblongifolia Champ. ex Benth. Guttiferae Source classification Phenols Polyphenols Plants Disease Research Fields Cancer	ATM/ATR STAT CDK Hedgehog
Garcinone C, a xanthone derivative, is a natural compound extracted from Garcinia oblongifolia that is used as an anti-inflammatory, astringency and granulation-promoting medicine, and has potential cytotoxic effects on certain cancers. Garcinone C stimulates the expression levels of ATR and *4E-BP1, arrests the cell cycle, inhibits cell viability of the human Nasopharyngeal carcinoma (NPC) cell lines CNE1, CNE2, HK1 and HONE1 in a time‑ and dose‑dependent manner through inhibition of Hedgehog* signaling pathway. Garcinone C is orally active .

HY-P1974

FR 901379 WF11899A	Structural Classification Microorganisms Antibiotics Source classification Other Antibiotics	Antibiotic
FR901379 (WF11899A) is a novel echinocandin-type lipopeptide antibiotic. FR901379 is primarily produced by mutant strain M-7 of Coleophoma empetri F-11899 (FERM BP-2635) .

HY-N14769

2-Hydroxyaclacinomycin B	Quinones Structural Classification Microorganisms Anthraquinones Source classification	Bacterial
2-Hydroxyaclacinomycin B is an anthracycline antibiotic. 2-Hydroxyaclacinomycin B can be found in Strptomyces galilaeus A-862 (FERM BP-45). 2-Hydroxyaclacinomycin B inhibits RNA synthesis and has anti-tumor activity .

HY-N0848R

Epibrassinolide (Standard) 24-Epibrassinolide (Standard); B1105 (Standard); BP55 (Standard)	Structural Classification Natural Products Source classification Plants Brassicaceae Brassica campestris L.	Apoptosis
Epibrassinolide (Standard) is the analytical standard of Epibrassinolide. This product is intended for research and analytical applications. Epibrassinolide (24-Epibrassinolide) is a ubiquitously occurring plant growth hormone which shows great potential to alleviate heavy metals and pesticide stress in plants[1]. Epibrassinolide is a potential apoptotic inducer in various cancer cells without affecting the non-tumor cell growth[2].

HY-N0252B

Catharanthine Sulfate (+)-3,4-Didehydrocoronaridine Sulfate	Cardiovascular Disease Apocynaceae Alkaloids Structural Classification Classification of Application Fields Source classification Plants Disease Research Fields Indole Alkaloids Catharanthus roseus (L.) G. Don	Calcium Channel
Catharanthine ((+)-3,4-Didehydrocoronaridine) Sulfate, a constituent of anticancer vinca alkaloids, inhibits voltage-operated L-type Ca ²⁺ channel (VOCC). Catharanthine Sulfate has IC₅₀s of 220 μM and 8 μM for VOCC currents in cardiomyocytes and vascular smooth muscle cells (VSMCs), respectively. Catharanthine Sulfate lowers blood pressure (BP), heart rate (HR). Catharanthine Sulfate has anti-cancer activity .

HY-N0252R

Catharanthine (Standard)	Apocynaceae Alkaloids Structural Classification Source classification Plants Indole Alkaloids Catharanthus roseus (L.) G. Don	Calcium Channel
Catharanthine (Standard) is the analytical standard of Catharanthine. This product is intended for research and analytical applications. Catharanthine ((+)-3,4-Didehydrocoronaridine), a constituent of anticancer vinca alkaloids, inhibits voltage-operated L-type Ca2+ channel (VOCC). Catharanthine has IC₅₀s of 220 μM and 8 μM for VOCC currents in cardiomyocytes and vascular smooth muscle cells (VSMCs), respectively. Catharanthine lowers blood pressure (BP), heart rate (HR). Catharanthine has anti-cancer activity .

HY-N6954R

Garcinone C (Standard)	Structural Classification other families Xanthones Garcinia oblongifolia Champ. ex Benth. Guttiferae Source classification Phenols Polyphenols Plants	ATM/ATR STAT CDK Hedgehog
Garcinone C (Standard) is the analytical standard of Garcinone C. This product is intended for research and analytical applications. Garcinone C, a xanthone derivative, is a natural compound extracted from Garcinia oblongifolia that is used as an anti-inflammatory, astringency and granulation-promoting medicine, and has potential cytotoxic effects on certain cancers. Garcinone C stimulates the expression levels of ATR and *4E-BP1, arrests the cell cycle, inhibits cell viability of the human Nasopharyngeal carcinoma (NPC) cell lines CNE1, CNE2, HK1 and HONE1 in a time‑ and dose‑dependent manner through inhibition of Hedgehog* signaling pathway. Garcinone C is orally active .

Cat. No.	Product Name	Chemical Structure

HY-B0309S2

Felodipine-d3
Felodipine-d₃ is the deuterium labeled Felodipine. Felodipine, a dihydropyridine, is a potent, vasoselective calcium channel antagonist. Felodipine lowers blood pressure (BP) by selective action on vascular smooth muscle, especially in the resistance vessels. Felodipine, an anti-hypertensive agent, induces autophagy. Felodipine can cross the blood-brain barrier .

HY-17401S

Ranolazine-d8 dihydrochloride

Ranolazine-d₈ (dihydrochloride) is the deuterium labeled Ranolazine dihydrochloride. Ranolazine dihydrochloride (CVT 303 dihydrochloride) is an anti-angina agent that achieves its effects by inhibiting the late phase of inward sodium current (INa and IKr with IC₅₀ values of 6 μM and 12 μM, respectively) without affecting heart rate or blood pressure (BP) . Ranolazine dihydrochloride is also a partial fatty acid oxidation inhibitor .

HY-B0280S2

Ranolazine-d3
Ranolazine-d₃ is the deuterium labeled Ranolazine. Ranolazine (CVT 303) is an anti-angina agent that achieves its effects by inhibiting the late phase of inward sodium current (INa and IKr with IC₅₀ values of 6 μM and 12 μM, respectively) without affecting heart rate or blood pressure (BP) . Ranolazine is also a partial fatty acid oxidation (FAO) inhibitor . Antianginal agent.

HY-B0280S1

Ranolazine-d8
Ranolazine-d₈ is the deuterium labeled Ranolazine. Ranolazine (CVT 303) is an anti-angina agent that achieves its effects by inhibiting the late phase of inward sodium current (INa and IKr with IC₅₀ values of 6 μM and 12 μM, respectively) without affecting heart rate or blood pressure (BP) . Ranolazine is also a partial fatty acid oxidation (FAO) inhibitor . Antianginal agent.

HY-13777S

Zoledronic acid-d5
Zoledronic acid-d₅ is deuterated labeled Zoledronic Acid (HY-13777). Zoledronic Acid (Zoledronate) is a third-generation bisphosphonate (BP), with potent anti-resorptive activity. Zoledronic Acid inhibits the differentiation and apoptosis of osteoclasts. Zoledronic Acid also has anti-cancer effects .

HY-B0309S1

Felodipine-d5
Felodipine-d₅ is deuterium labeled Felodipine. Felodipine, a dihydropyridine, is a potent, vasoselective calcium channel antagonist. Felodipine lowers blood pressure (BP) by selective action on vascular smooth muscle, especially in the resistance vessels. Felodipine, an anti-hypertensive agent, induces autophagy. Felodipine can cross the blood-brain barrier .

HY-132670S

(R)-(-)-Felodipine-d5

(R)-(-)-Felodipine-d₅ is the deuterium labeled (R)-(-)-Felodipine. (R)-(-)-Felodipine is the S enantiomer of Felodipine. Felodipine, a dihydropyridine, is a potent, vasoselective calcium channel antagonist. Felodipine lowers blood pressure (BP) by selective action on vascular smooth muscle, especially in the resistance vessels. Felodipine, an anti-hypertensive agent, induces autophagy. Felodipine can cross the blood-brain barrier .

HY-B0280S

Ranolazine-d5
Ranolazine-d₅ is the deuterium labeled Ranolazine. Ranolazine (CVT 303) is an anti-angina drug that achieves its effects by inhibiting the late phase of inward sodium current (INa and IKr with IC₅₀ values of 6 μM and 12 μM, respectively) without affecting heart rate or blood pressure (BP) . Ranolazine is also a partial fatty acid oxidation (FAO) inhibitor . Antianginal agent.

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