N4BP1 Antibody (YA3286)

N4BP1 Antibody (YA3286) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3286), targeting N4BP1, with a predicted molecular weight of 99 kDa (observed band size: 99 kDa). N4BP1 Antibody (YA3286) can be used for WB, IP experiment in human background.

N4BP1 is a potent suppressor of cytokine production that functions as a regulator of innate immune signaling and inflammation. It serves as a key negative regulator of select cytokine and chemokine responses triggered by TRIF-independent Toll-like receptors (TLRs), thereby limiting inflammatory cytokine responses to minor insults. In response to more threatening pathogens, N4BP1 is cleaved by CASP8 downstream of TLR3 or TLR4, leading to its inactivation and allowing the production of inflammatory cytokines. By similarity, N4BP1 acts as a restriction factor against some viruses by binding to mRNA viruses and mediating their degradation via its ribonuclease activity. Additionally, N4BP1 inhibits the E3 ubiquitin-protein ligase ITCH by interacting with its second WW domain, competing with ITCH's substrates and impairing their ubiquitination.

Q6A037

Predicted band size: 99 kDa; Observed band size: 99 kDa

Affinity Purified

Non-conjugated

Unmodified

Epigenetics and Nuclear Signaling

Primary Antibody; Recombinant Rabbit Monoclonal Antibody

Recombinant, Monoclonal

Rabbit

Human

WB: 1/500-1/1000;IP: 1/20

WB, IP

Liquid

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG

Endogenous

Recombinant protein of mouse N4BP1