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  3. Cytokines and Growth Factors
  4. Interleukin & Receptors
  5. IL-18BP
  6. IL-18BP Protein, Cynomolgus (HEK293, His)

The IL-18BP protein is an inhibitor of IL-18, which binds to IL-18 and prevents IL-18 from binding to its receptor, thereby inhibiting IL-18-induced IFN-γ production. IL-18BP protein is constitutively expressed and secreted in monocytes. IFN-γ can enhance the expression of this protein. IL-18BP Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived IL-18BP protein, expressed by HEK293 , with C-His labeled tag.

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Description

The IL-18BP protein is an inhibitor of IL-18, which binds to IL-18 and prevents IL-18 from binding to its receptor, thereby inhibiting IL-18-induced IFN-γ production. IL-18BP protein is constitutively expressed and secreted in monocytes. IFN-γ can enhance the expression of this protein. IL-18BP Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived IL-18BP protein, expressed by HEK293 , with C-His labeled tag.
Background

Interleukin-18 is an interferon (IFN-γ) inducer and a member of the interleukin-1 (IL-1) cytokine family. IL-1 cytokines and their receptors are involved in inflammation, fever, and immune stimulation. IL-18 binding protein is an inhibitor of IL-18, which binds to IL-18 and prevents IL-18 from binding to its receptor, thereby inhibiting IL-18-induced IFN-γ production. IL-18 binding protein is constitutively expressed and secreted in monocytes. IFN-γ can enhance the expression of this protein[1][2].
Species

Cynomolgus
Source

HEK293
Tag

C-His
Accession

A0A2K5UDJ4 (T28-P207)
Gene ID
Molecular Construction
N-term
IL-18BP (T28-P207)
Accession # A0A2K5UDJ4
His
C-term
Synonyms
IL-18BP; Igifbp; Interleukin-18-binding protein
Molecular Weight

35-65 kDa
Purity

Greater than 95% as determined by reducing SDS-PAGE.
Endotoxin Level

<1 EU/μg, determined by LAL method.
Documentation
Handling Instructions (2659 KB)

IL-18BP Protein, Cynomolgus (HEK293, His) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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IL-18BP Protein, Cynomolgus (HEK293, His)
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