Search Result

Results for "

AGN 193109-d<sub>7</sub>

" in MedChemExpress (MCE) Product Catalog:

By Targets:	P-glycoprotein (20) 11β-HSD (3) 5 alpha Reductase (4) 5-HT Receptor (99) Acetolactate Synthase (ALS) (1) ADC Payload (14) Adenosine Receptor (19) Adrenergic Receptor (115) AIM2 (1) Akt (15) Aldehyde Dehydrogenase (ALDH) (2) Aldose Reductase (1) Amino Acid Derivatives (11) Aminopeptidase (2) AMPK (10) Amyloid-β (13) Anaplastic lymphoma kinase (ALK) (10) Androgen Receptor (27) Angiotensin Receptor (26) Angiotensin-converting Enzyme (ACE) (24) Antibiotic (219) Antifolate (8) AP-1 (1) Apical Sodium-Dependent Bile Acid Transporter (3) Apolipoprotein (1) Apoptosis (365) Arenavirus (1) Aryl Hydrocarbon Receptor (11) Atg7 (1) Atg8/LC3 (1) ATM/ATR (1) ATP Citrate Lyase (2) ATP Synthase (1) Aurora Kinase (1) Autophagy (358) Bacterial (341) Bcl-2 Family (6) Bcr-Abl (13) BCRP (3) Beta-lactamase (8) Beta-secretase (3) Biochemical Assay Reagents (71) Btk (4) c-Fms (3) c-Kit (21) c-Met/HGFR (6) Calcium Channel (70) Cannabinoid Receptor (13) Carbonic Anhydrase (12) Carboxylesterase (CES) (1) Casein Kinase (1) Caspase (14) CaSR (4) Cathepsin (1) CCR (1) CD73 (1) CDK (12) CFTR (12) CGRP Receptor (5) Checkpoint Kinase (Chk) (1) Chloride Channel (4) Cholinesterase (ChE) (23) CMV (3) Complement System (9) COMT (8) Constitutive Androstane Receptor (1) COX (85) CRFR (1) Cuproptosis (2) CXCR (1) Cyclophilin (2) Cytochrome P450 (48) Dengue Virus (2) Deubiquitinase (1) Dihydroorotate Dehydrogenase (3) Dihydropyrimidine Dehydrogenase (DPD) (1) Dipeptidyl Peptidase (24) Disulfidptosis (4) DNA Alkylator/Crosslinker (9) DNA Methyltransferase (5) DNA/RNA Synthesis (100) Dopamine Receptor (65) Drug Derivative (8) Drug Intermediate (14) Drug Isomer (2) Drug Metabolite (99) Drug-Linker Conjugates for ADC (6) DYRK (2) E1/E2/E3 Enzyme (2) EAAT (2) EBI2/GPR183 (1) EGFR (23) Elastase (1) Endogenous Metabolite (970) Endothelin Receptor (5) Enterovirus (6) Epigenetic Reader Domain (3) ERK (13) Estrogen Receptor/ERR (48) Factor Xa (7) FAK (1) Fatty Acid Synthase (FASN) (4) Ferroptosis (58) FGFR (14) FKBP (8) Flavivirus (4) FLT3 (11) Fluorescent Dye (7) Free Fatty Acid Receptor (1) Fungal (88) FXR (8) G protein-coupled Bile Acid Receptor 1 (3) G Protein-coupled Receptor Kinase (GRK) (1) G2A (GPR132) (1) GABA Receptor (36) Gap Junction Protein (4) GCGR (1) GLP Receptor (1) Glucocorticoid Receptor (32) Glucosylceramide Synthase (GCS) (2) Glutathione Peroxidase (2) Glutathione Reductase (GR) (1) Glutathione S-transferase (1) Glycosidase (4) GlyT (3) GnRH Receptor (6) GPR119 (1) GPR35 (1) GPR55 (2) GSK-3 (6) Guanylate Cyclase (2) HBV (12) HCV (24) HCV Protease (3) HDAC (20) Hedgehog (5) Herbicide (8) Hexokinase (2) HIF/HIF Prolyl-Hydroxylase (3) Histamine Receptor (48) Histone Acetyltransferase (8) Histone Demethylase (6) Histone Methyltransferase (2) HIV (83) HIV Integrase (15) HIV Protease (17) HMG-CoA Reductase (HMGCR) (18) HPPD (1) HSP (6) HSV (31) IGF-1R (5) iGluR (30) IKK (4) Imidazoline Receptor (6) IMPDH (1) Indoleamine 2,3-Dioxygenase (IDO) (2) Influenza Virus (40) Insecticide (4) Insulin Receptor (1) Integrin (1) Interleukin Related (16) IRE1 (1) Isocitrate Dehydrogenase (IDH) (2) Isotope-Labeled Compounds (3460) JAK (13) JNK (6) Keap1-Nrf2 (15) Ketohexokinase (2) Kinesin (1) LDLR (3) Leukotriene Receptor (12) Ligands for E3 Ligase (8) Ligands for Target Protein for PROTAC (2) Liposome (3) Lipoxygenase (3) LPL Receptor (7) mAChR (50) MAP3K (1) MDM-2/p53 (4) MEK (7) Melanocortin Receptor (2) Melatonin Receptor (9) mGluR (10) MHC (1) MicroRNA (1) Microsomal Triglyceride Transfer Protein (MTP) (1) Microtubule/Tubulin (19) Mineralocorticoid Receptor (13) Mitochondrial Metabolism (13) Mitophagy (53) MMP (11) Molecular Glues (13) Monoamine Oxidase (17) Monoamine Transporter (2) mTOR (11) Myosin (9) Na+/H+ Exchanger (NHE) (1) Na+/K+ ATPase (6) nAChR (13) NADPH Oxidase (1) Necroptosis (2) Neprilysin (8) Neurokinin Receptor (6) NF-κB (47) NKCC (2) NO Synthase (28) NOD-like Receptor (NLR) (3) Notch (7) Nuclear Factor of activated T Cells (NFAT) (2) Nuclear Hormone Receptor 4A/NR4A (2) Nucleoside Antimetabolite/Analog (68) OAT (1) Opioid Receptor (9) Orexin Receptor (OX Receptor) (1) Organoid (3) Orthopoxvirus (17) Oxidative Phosphorylation (2) P2X Receptor (3) P2Y Receptor (8) p38 MAPK (15) PAI-1 (1) PAK (8) Parasite (92) PARP (8) PDGFR (23) Penicillin-binding protein (PBP) (3) PERK (2) PGC-1α (1) Phosphatase (10) Phosphodiesterase (PDE) (32) Phospholipase (9) Photosensitizer (2) PI3K (6) PINK1/Parkin (1) PKA (2) PKC (12) Potassium Channel (37) PPAR (33) Prion Protein (1) Progesterone Receptor (31) Prostaglandin Receptor (35) PROTAC Linkers (3) Protease Activated Receptor (PAR) (1) Proteasome (1) Proton Pump (29) Protoporphyrinogen IX oxidase (1) Pyruvate Kinase (1) Quinone Reductase (1) Raf (10) RAR/RXR (33) Ras (3) Reactive Oxygen Species (ROS) (78) Reference Standards (15) Renin (2) RET (7) Reverse Transcriptase (18) ROCK (1) ROS Kinase (7) RSV (8) SARS-CoV (55) Ser/Thr Protease (2) Serotonin Transporter (37) SGLT (9) Sigma Receptor (4) Sirtuin (8) Small Interfering RNA (siRNA) (3) Smo (1) SOD (2) Sodium Channel (49) Somatostatin Receptor (1) Src (8) STAT (10) STING (2) Syk (1) TAM Receptor (3) Tau Protein (1) TGF-beta/Smad (7) Thrombin (11) Thrombopoietin Receptor (5) Thymidylate Synthase (5) Thyroid Hormone Receptor (7) TNF Receptor (10) Toll-like Receptor (TLR) (9) TOPK (1) Topoisomerase (29) Trk Receptor (5) TRP Channel (17) Tyrosinase (8) URAT1 (1) Vasopressin Receptor (1) VD/VDR (17) VEGFR (35) Virus Protease (18) VKOR (1) WDR5 (1) Wee1 (1) Xanthine Oxidase (7) YAP (1) β-catenin (4) γ-secretase (1)
By Research Areas:	Cancer (1140) Cardiovascular Disease (359) Endocrinology (269) Infection (564) Inflammation/Immunology (509) Metabolic Disease (547) Neurological Disease (593)
Click Chemistry:	Labeling and Fluorescence Imaging (1) Azide (2) Alkynes (17)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

4344

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

MCE Kits

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

4214

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oligonucleotides

Targets Recommended: P-glycoprotein

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W742417

Tazarotenic acid-d8 AGN 190299-d<sub>8sub>	Isotope-Labeled Compounds Drug Metabolite	Inflammation/Immunology
Tazarotenic acid-d₈ (AGN 190299-d₈) is the deuterium labeled Tazarotenic acid (HY-101108). Tazarotenic acid is the metabolite of Tazarotene (HY-15388) .

HY-U00449S

AGN 193109-d7	Isotope-Labeled Compounds RAR/RXR	Cancer
AGN 193109-d₇ is the deuterium labeled AGN 193109. AGN 193109 is a retinoid analog, and acts as a specific and highly effective antagonist of retinoic acid receptors (RARs), with Kds of 2 nM, 2 nM, and 3 nM for RARα, RARβ, and RARγ, respectively.

HY-123754

AGN-201904	Proton Pump	Inflammation/Immunology
AGN-201904 is a proton pump inhibitor. AGN-201904 is an omeprazole prodrug that can delay aging and can be used to prevent and treat peptic ulcers .

HY-146227

DNA topoisomerase II inhibitor 1	Topoisomerase Apoptosis	Cancer
DNA topoisomerase II inhibitor 1 (compound 8ed) is a potent DNA topoisomerase II inhibitor. DNA topoisomerase II inhibitor 1 shows anti-proliferative activity. DNA topoisomerase II inhibitor 1 induces apoptosis and cell cycle arrest at sub G1 phase .

HY-RS13999

SUB1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SUB1 Human Pre-designed siRNA Set A contains three designed siRNAs for SUB1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SUB1 Human Pre-designed siRNA Set A SUB1 Human Pre-designed siRNA Set A

HY-RS18793

Sub1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Sub1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Sub1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Sub1 Mouse Pre-designed siRNA Set A Sub1 Mouse Pre-designed siRNA Set A

HY-RS25282

Sub1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Sub1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Sub1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Sub1 Rat Pre-designed siRNA Set A Sub1 Rat Pre-designed siRNA Set A

HY-15388S3

Tazarotene-d6 AGN 190168-d<sub>6sub>	Isotope-Labeled Compounds	Inflammation/Immunology Cancer
Tazarotene-d₆ (AGN 190168-d₆) is deuterium labeled Tazarotene. Tazarotene (AGN 190168) is a selective retinoic acid receptor (RAR) agonist for the treatment of plaque psoriasis and acne vulgaris. Tazarotene is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-15388S

Tazarotene-d8 AGN 190168-d<sub>8sub>	Isotope-Labeled Compounds RAR/RXR Autophagy	Inflammation/Immunology Cancer
Tazarotene-d₈ is the deuterium labeled Tazarotene. Tazarotene (AGN 190168) is a selective retinoic acid receptor (RAR) agonist for the treatment of plaque psoriasis and acne vulgaris .

HY-15388S2

Tazarotene-13C6 AGN 190168-¹³C<sub>6sub>	Isotope-Labeled Compounds RAR/RXR Autophagy	Inflammation/Immunology Cancer
Tazarotene- ¹³C₆ (AGN 190168- ¹³C₆) is ¹³C labeled Tazarotene. Tazarotene (AGN 190168) is a selective retinoic acid receptor (RAR) agonist for the treatment of plaque psoriasis and acne vulgaris. Tazarotene is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-15388S1

Tazarotene-13C2,d2 AGN 190168-¹³C<sub>2sub>,d<sub>2sub>	Isotope-Labeled Compounds	Inflammation/Immunology Cancer
Tazarotene-13C2,d2 (AGN 190168-13C2,d2) is the ¹³C and deuterium labeled isotope of Tazarotene (HY-15388). Tazarotene (AGN 190168) is a selective retinoic acid receptor (RAR) agonist for the treatment of plaque psoriasis and acne vulgaris. Tazarotene is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups .

HY-118364

AGN 190727	RAR/RXR	Metabolic Disease
AGN 190727 is a structural isomer of AGN 190121 and has no activating effect on RAR/RXR. AGN 190121 is a RAR-specific agonist that causes a dose-dependent increase in serum triglycerides, leading to hypertriglyceridemia.

HY-14605S

Rasagiline-13C3 mesylate (R)-AGN1135-¹³C<sub>3sub> mesylate; TVP1012-¹³C<sub>3sub> mesylate	Isotope-Labeled Compounds Autophagy Monoamine Oxidase Apoptosis	Others
Rasagiline- ¹³C₃ ((R)-AGN1135- ¹³C₃; TVP1012- ¹³C₃) mesylate is the deuterium labeled Rasagiline (mesylate) (HY-14605) . Rasagiline (R-AGN1135) mesylate is a highly potent selective irreversible mitochondrial monoamine oxidase (MAO) inhibitor with IC₅₀s of 4.43 nM and 412 nM for rat brain MAO B and A activity, respectively .

HY-U00449A

AGN 193109 sodium	RAR/RXR	Cancer
AGN 193109 sodium is the sodium salt form of AGN 193109 (HY-U00449). AGN 193109 sodium is the pan antagonist for retinoic acid receptor (RAR), with K_d of 2, 2 and 3 nM, for RARα, RARβ and RARγ, respectively. AGN 193109 sodium reverses TTNPB-induced morphology changes and all-trans retinoic acid (tRA)/9-cis RA/13-cis RA-induced proliferation suppression in ECE16-1 cell. AGN 193109 sodium is the antidote for retinoic acidosis, that ameliorates the skin and mucosal toxicity .

HY-U00449G

AGN 193109	RAR/RXR	Cancer
AGN 193109 (GMP) is AGN 193109 (HY-U00449) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. AGN 193109 is a specific and highly effective retinoic acid receptor (RAR) antagonist . AGN 193109 (GMP) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. AGN 193109 is the antidote for retinoic acidosis, that ameliorates the skin and mucosal toxicity.

HY-105689

AGN 192870	RAR/RXR	Others
AGN 192870 is a RAR neutral antagonist with K_ds of 147, 33, and 42 nM for RARα, RARβ, and RARγ, respectively. AGN 192870 shows IC₅₀s of 87 and 32 nM for RARαand RARγ, respectively. AGN 192870 shows RARβ partial agonism . AGN 192870 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-123328

AGN 191976	Prostaglandin Receptor	Cardiovascular Disease
AGN 191976 is a potent and selective thromboxane A₂-sensitive (TP) receptor agonist with EC₅₀ values of 0.23 nM and 24 nM in rat aorta and human platelets, respectively. AGN 191976 has potent IOP-lowering effects in dogs and monkeys. AGN 191976 can be used to study vascular biology and the role of thromboxane A₂ in vascular function .

HY-U00449

**AGN 193109** 5+ Cited Publications	RAR/RXR	Cancer
AGN 193109 is a retinoid analog, and acts as a specific and highly effective antagonist of retinoic acid receptors (RARs), with K_ds of 2 nM, 2 nM, and 3 nM for RARα, RARβ, and RARγ, respectively. AGN 193109 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. AGN 193109 is the antidote for retinoic acidosis, that ameliorates the skin and mucosal toxicity.

HY-100273

AGN 194078	RAR/RXR Autophagy	Cancer
AGN 194078 is a selective RARα agonist with a K_d and EC₅₀ of 3 and 112 nM, respectively.

HY-19923

Aganepag isopropyl AGN-210961	Prostaglandin Receptor	Endocrinology
Aganepag isopropyl (AGN-210961) is an EP2 agonist .

HY-10844S1

Pretomanid-d5 PA-824-d<sub>5sub>; (S)-PA 824-d<sub>5sub>	Antibiotic Bacterial Isotope-Labeled Compounds	Infection Cancer
Pretomanid-d₅ is deuterated labeled Pretomanid (HY-10844). Pretomanid (PA-824) is an antibiotic used for the research of multi-drug-resistant tuberculosis affecting the lungs. Pretomanid exhibits a sub-micromolar MIC against M. tuberculosis (MTB). The MIC values of PA-824 against a panel of MTB pan-sensitive and Rifampin mono-resistant clinical isolates range from 0.015 to 0.25 μg/mL.

HY-101108S1

Tazarotenic acid-13C2,d2 AGN 190299-¹³C<sub>2sub>,d<sub>2sub>	Drug Metabolite Isotope-Labeled Compounds	Others
Tazarotenic acid-13C2,d2 (AGN 190299-13C2,d2) is the ¹³C and deuterium labeled isotope of Tazarotenic acid (HY-101108). Tazarotenic acid is the metabolite of Tazarotene. Tazarotenic acid binding to retinoic acid receptors (RARs) is the probable molecular target of retinoid action. Tazarotenic acid has the potential for the research of warty dyskeratoma .

HY-P10215

Ac-{Cpg}-Thr-Ala-{Ala(CO)}-Asp-{Cpg}-NH2	Parasite	Infection
Ac-{Cpg}-Thr-Ala-{Ala(CO)}-Asp-{Cpg}-NH2 (compound 40) is a potent **Plasmodium subtilisin-like protease 1 (SUB1)** inhibitor. SUB1-IN-1 shows IC₅₀ values of 12 nM and 10 nM against P. vivax and P. falciparum SUB1 (Pv- and PfSUB1), respectively .

HY-16684

AGN-195183 IRX-5183; VTP-195183; NRX-195183	RAR/RXR Autophagy	Cancer
AGN-195183 (IRX-5183) is a potent and selective agonist of RARα (K_d=3 nM) with improved binding selectivity relative to AGN 193836. AGN-195183 has no activity on RARβ/γ.

HY-117926

AGN 191701	RAR/RXR	Cancer
AGN 191701 is a selective retinoic acid X receptor (RXR) agonist that causes liver enlargement in rats without hepatocellular necrosis .

HY-14897

Rezatomidine AGN-203818	Adrenergic Receptor	Neurological Disease Metabolic Disease
Rezatomidine (AGN-203818) is a potent and selective α2-AR agonist. Rezatomidine can be used for diabetic neuropathy and neuropathic pain research .

HY-123662

AGN-201904Z	Proton Pump	Others
AGN-201904Z is a compound that inhibits gastric acid secretion and is a new type of proton pump inhibitor that can produce more significant and lasting acid suppression effects than esomeprazole.

HY-102053

Apimostinel NRX-1074; AGN-241660	iGluR	Neurological Disease
Apimostinel (NRX-1074; AGN-241660) is an orally active NMDA receptor partial agonist .

HY-16685

AGN 205327	RAR/RXR Autophagy	Cancer
AGN 205327 is a potent synthetic RARs agonist with EC50 of 3766/734/32 nM for RARα/β/γ respectively; no inhibition on RXR.

HY-B0191AS

5,6-trans-Bimatoprost-d5 5,6-trans-AGN 192024-d<sub>5sub>	Isotope-Labeled Compounds Prostaglandin Receptor	Cancer
5,6-trans-Bimatoprost-d₅ (5,6-trans-AGN 192024-d₅) is the deuterium labeled 5,6-trans-Bimatoprost (HY-B0191A). 5,6-trans-Bimatoprost is the isomer of Bimatoprost (HY-B0191), and can be used as an experimental control. Bimatoprost is a prostaglandin analogue that can be used in studies of ocular hypertension and glaucoma and also has anti-fat formation effects.

HY-16683

AGN 205728	RAR/RXR Autophagy	Cancer
AGN 205728 is a potent and selective RARγ antagonist with Ki/IC95 values of 3 nM/ 0.6 nM; no inhibiton on RARα and RARβ.

HY-101374A

AGN 192403 hydrochloride BRD4780 hydrochloride	Imidazoline Receptor	Cardiovascular Disease Neurological Disease
AGN 192403 (BRD4780) hydrochloride is an I1-Imidazoline receptor antagonist for cardiovascular and neurological research .

HY-12309

EC23 AGN 190205; BASF-46928	Organoid	Neurological Disease
EC23 (AGN 190205) is a stable synthetic retinoid analogue and induces neuronal differentiation .

HY-16681

AGN 194310 5+ Cited Publications VTP-194310	RAR/RXR Autophagy	Cancer
AGN 194310 (VTP-194310) is a high affinity, potent and selective retinioic acid receptors (RARs) pan-antagonist with K_d values of 3 nM, 2 nM, 5 nM for RARα, RARβ, RARγ, respectively . AGN 194310 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-14898

AGN 210676 Simenepag	Prostaglandin Receptor	Inflammation/Immunology Endocrinology
AGN 210676 is a selective prostaglandin EP₂ agonist extracted from patent US20070203222A1, Compound example 23, has an EC₅₀ of 5 nM.

HY-16682

AGN 196996 3 Publications Verification	RAR/RXR Autophagy	Cancer
AGN 196996 is a potent and selective RARα antagonist with Ki value of 2 nM; little binding affinity for RARβ(Ki=1087 nM) and RARγ(Ki=8523 nM).

HY-109164

Zelquistinel AGN-241751; GATE-251	iGluR	Neurological Disease
Zelquistinel (AGN-241751) is the orally active N-methyl-D-aspartate (NMDA) receptor partial agonist used for the research of depression, anxiety and other related psychiatric disorders .

HY-W719338

Pentane-1,2-diol-d7 (±)-Pentane-1,2-diol<sub>7sub>; 1,2-Dihydroxypentane<sub>7sub>; 1,2-Pentylene glycol<sub>7sub>; Diol PD<sub>7sub>; Hydrolite 5<sub>7sub>; NSC 513<sub>7sub>; 1,2-Pentanediol<sub>7sub>	Isotope-Labeled Compounds	Others
Pentane-1,2-diol-d₇ ((±)-Pentane-1,2-diol-d₇; 1,2-Dihydroxypentane-d₇; 1,2-Pentylene glycol-d₇; Diol PD-d₇; Hydrolite 5-d₇; NSC 513-d₇; 1,2-Pentanediol-d₇) is the deuterium labeled Pentane-1,2-diol (HY-Y1249).

HY-107327S

Carazolol-d7 (±)-Carazolol-d<sub>7sub>; DL-Carazolol-d<sub>7sub>; Suacron-d<sub>7sub>	Isotope-Labeled Compounds Adrenergic Receptor	Cardiovascular Disease
Carazolol-d₇ is the deuterium labeled Carazolol (HY-107327). Carazolol is a highly potent antagonist of β₁/β₂ adrenoceptor. Carazolol is also a potent, selective β₃-adrenoceptor agonist. Carazolol can be used in the research of hypertension .

HY-N0006S

Demethoxycurcumin-d7 Curcumin II-d<sub>7sub>; Desmethoxycurcumin-d<sub>7sub>; Monodemethoxycurcumin-d<sub>7sub>	Isotope-Labeled Compounds Apoptosis Autophagy Bacterial	Inflammation/Immunology Cancer
Demethoxycurcumin-d₇ is the deuterium labeled Demethoxycurcumin. Demethoxycurcumin(Curcumin II), a major active curcuminoid, possess anti-inflammatory properties; also exert cytotoxic effects in human cancer cells via induction of apoptosis.

HY-B0584S2

Travoprost-d7 Fluprostenol isopropyl ester-<sub>7sub>; AL6221-<sub>7sub>; Flu-Ipr-<sub>7sub>	Isotope-Labeled Compounds Prostaglandin Receptor	Cardiovascular Disease Endocrinology
Travoprost-d₇ (Fluprostenol isopropyl ester-d₇) is deuterium labeled Travoprost. Travoprost (Fluprostenol isopropyl ester), an isopropyl ester proagent, is a high affinity, selective FP prostaglandin full receptor agonist. Travoprost has the ocular hypotensive efficacy and has the potential for glaucoma and ocular hypertension .

HY-100300

AGN 192836	Adrenergic Receptor	Cardiovascular Disease Endocrinology
AGN 192836 is a potent and selective α2 adrenergic agonist with EC₅₀s of 8.7, 41 and 6.6 nM for α2A, α2B and α2C receptor, respectively.

HY-B0389S6

D-Glucose-d7 Glucose-d<sub>7sub>; D-(+)-Glucose-d<sub>7sub>; Dextrose-d<sub>7sub>	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease
D-Glucose-d₇7 is the deuterium labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response .

HY-66005S2

Acetaminophen-d7 Paracetamol-d<sub>7sub>; 4-Acetamidophenol-d<sub>7sub>; 4'-Hydroxyacetanilide-d<sub>7sub>	COX Endogenous Metabolite Histone Acetyltransferase	Inflammation/Immunology
Acetaminophen-d₇ is the deuterium labeled Acetaminophen. Acetaminophen (Paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 25.8 μM; is a widely used antipyretic and analgesic agent. Acetaminophen is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor.

HY-D0711S2

Indocyanine green-d7 Foxgreen-d<sub>7sub>; IC Green-d<sub>7sub>; Cardiogreen-d<sub>7sub>	Isotope-Labeled Compounds Fluorescent Dye	Others
Indocyanine green-d7 (Foxgreen-d7) is the deuterium labeled Indocyanine green (HY-D0711). Indocyanine green is a low toxicic fluorescent agent that has been widely used in medical diagnostics, such as determining cardiac output, hepatic function, and liver blood flow, and for ophthalmic angiography .

HY-107352S

Fosfenopril-d7 Fosinoprilat-d<sub>7sub>; Fosinoprilic acid-d<sub>7sub>; SQ 27519-d<sub>7sub>	Angiotensin-converting Enzyme (ACE) Interleukin Related NF-κB TNF Receptor Toll-like Receptor (TLR) Isotope-Labeled Compounds	Others
Fosfenopril-d₇ is deuterium labeled Fosfenopril.

HY-N7101S

Cefpodoxime proxetil-d7 U-76-d<sub>7sub>,252-d<sub>7sub>; CS-807-d<sub>7sub>	Isotope-Labeled Compounds Bacterial Antibiotic Penicillin-binding protein (PBP)	Infection
Cefpodoxime proxetil-d₇ (U-76-d₇,252-d₇; CS-807-d₇) is the deuterium labeled Cefpodoxime Proxetil (HY-N7101). Cefpodoxime Proxetil is an orally active broad spectrum third-generation cephalosporin with potent antibacterial activity against both Gram-positive and Gram-negative bacteria including staphylococci, streptococci, Haemophilus influenzae, Neisseria gonorrhoeae, Escherichia coli, Klebsiella pnuemoniae, Citrobacter spp, and Proteus spp. Cefpodoxime Proxetil binds to penicillin binding proteins (PBPs), which inhibits peptidoglycan synthesis, finally results in interfering bacterial cell wall biosynthesis. Cefpodoxime Proxetil can be used against skin structure infections, acute otitis media, pharyngitis, tonsillitis, upper respiratory tract infection, urinary tract infections and sexually transmitted diseases .

HY-12057S1

Vemurafenib-d7 PLX4032-d<sub>7sub>; RG7204-d<sub>7sub>; RO5185426-d<sub>7sub>	Isotope-Labeled Compounds Raf Autophagy	Cancer
Vemurafenib-d₇ is deuterium labeled Vemurafenib. Vemurafenib (PLX4032) is a first-in-class, selective, potent inhibitor of B-RAF kinase, with IC₅₀s of 31 and 48 nM for RAFV600E and c-RAF-1, respectively . Vemurafenib induces cell autophagy .

HY-15149S2

Romidepsin-d7 FK 228-d<sub>7sub>; FR 901228-d<sub>7sub>; NSC 630176-d<sub>7sub>	Isotope-Labeled Compounds HDAC Apoptosis	Cancer
Romidepsin-d₇ (FK 228-d₇) is deuterium labeled Romidepsin. Romidepsin (FK 228) is a Histone deacetylase (HDAC) inhibitor with anti-tumor activities. Romidepsin (FK 228) inhibits HDAC1, HDAC2, HDAC4, and HDAC6 with IC₅₀s of 36 nM, 47 nM, 510 nM and 1.4 μM, respectively . Romidepsin (FK 228) is produced by Chromobacterium violaceum, induces cell G2/M phase arrest and apoptosis .

HY-B1548S

Benznidazole-d7 Benznidazol-d<sub>7sub>; Ro 07-1051-d<sub>7sub>; Ro 71051-d<sub>7sub>	Isotope-Labeled Compounds Parasite Antibiotic	Infection
Benznidazole-d₇ (Benznidazol-d₇; Ro 07-1051-d₇; Ro 71051-d₇) is the deuterium labeled Benznidazole (HY-B1548). Benznidazole (Ro 07-1051) is an antiparasitic medication, with an IC₅₀ of 20.35 μM for Colombian T. cruzi strains, and has been used in the treatment of Chagas disease .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-125833

Alpha-Naphthoflavone 5+ Cited Publications	Flavonoids Flavones Source classification Indigofera heterantha Wall. ex Brand. Plants Compositae Disease Research Fields Cancer	Cytochrome P450 Aryl Hydrocarbon Receptor Apoptosis
Alpha-Naphthoflavone is an orally active flavonoid that is a potent, competitive inhibitor of aromatase< b>aromatase. < b > IC < sub > 50 < / sub > < / b > and < b > K < sub > I < / sub > < / b > value were 0.5 and 0.2 microns. Alpha-Naphthoflavone can inhibit cell proliferation and induce apoptosis .

HY-W011474

Geranylgeraniol	Structural Classification Natural Products Microorganisms	NF-κB
Geranylgeraniol is an orally acitve vitamin K₂ sub-type, an intermediate of the mevalonate pathway. Geranylgeraniol targets NF-kB signaling pathway and could alleviate LPS-induced microglial inflammation in animal model .

HY-P2274

Argifin	Infection Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Disease Research Fields	Parasite
Argifin is a sub-nanomolar chitinase inhibitor produced by soil microorganisms, with IC₅₀s of 0.025 μM, 6.4 μM , 1.1 μM and 4.5 μM for SmChiA (Serratia marcescens chitinaese A), SmChiB, Aspergillus fumigatus chitinase B1 and human chitotriosidase, respectively .

HY-W011474R

Geranylgeraniol (Standard)	Structural Classification Natural Products Microorganisms	Reference Standards NF-κB
Geranylgeraniol (Standard) is the analytical standard of Geranylgeraniol. This product is intended for research and analytical applications. Geranylgeraniol is an orally acitve vitamin K2 sub-type, an intermediate of the mevalonate pathway. Geranylgeraniol targets NF-kB signaling pathway and could alleviate LPS-induced microglial inflammation in animal model [4].

HY-N0662

Amentoflavone Maximum Cited Publications 10 Publications Verification Didemethyl-ginkgetin	Structural Classification Flavonoids Classification of Application Fields Source classification Phenols Polyphenols Selaginellaceae Plants Biflavones Selaginella tamariscina (P. Beauv.) Spring Disease Research Fields Cancer	Reactive Oxygen Species (ROS) Apoptosis Bacterial Fungal RSV GABA Receptor
Amentoflavone (Didemethyl-ginkgetin) is a potent and orally active GABA(A) negative modulator. Amentoflavone also shows anti-inflammatory, antioxidative, anti-viral, anti-tumor, anti-radiation, anti-fungal, antibacterial activity. Amentoflavone induces apoptosis and cell cycle arrest at sub-G1 phase .

HY-125833R

Alpha-Naphthoflavone (Standard)	Flavonoids Flavones Source classification Indigofera heterantha Wall. ex Brand. Plants Compositae	Cytochrome P450 Aryl Hydrocarbon Receptor Apoptosis
Alpha-Naphthoflavone (Standard) is the analytical standard of Alpha-Naphthoflavone. This product is intended for research and analytical applications. Alpha-Naphthoflavone is an orally active flavonoid that is a potent, competitive inhibitor of aromatase< b>aromatase. < b > IC < sub > 50 < / sub > < / b > and < b > K < sub > I < / sub > < / b > value were 0.5 and 0.2 microns. Alpha-Naphthoflavone can inhibit cell proliferation and induce apoptosis .

HY-N11799

Neochilenin 3-O-Methylquercetin 4′-O-glucoside	Structural Classification Flavonoids Source classification Plants Compositae Other Flavonoids	Others
Neochilenin (3-O-Methylquercetin 4 '-O-glucoside) is a glycoside of 3-O-methylquercetin, which can be isolated from the sub-family Cereoideae (Cactaceae). .

HY-N15356

9-Oxooctadecanedioic acid	Structural Classification Ketones, Aldehydes, Acids Source classification Plants Quercus suber L. Fagaceae	Bacterial
9-Oxooctadecanedioic acid is an α,ω-dicarboxylic fatty acid monomer found in the cork suberin of Quercus suber. It contributes to the formation of the hydrophobic barrier structure in plant cell walls and may play an important role in functions such as water resistance and protection against microbial penetration .

HY-N10192

Aculene D	Infection Microorganisms Classification of Application Fields Terpenoids Sesquiterpenes Source classification Disease Research Fields	Endogenous Metabolite Bacterial
Aculene D, a fungal metabolite, shows quorum sensing (QS) inhibitory activity against Chromobacterium violaceum CV026, and could significantly reduce violacein production in N-hexanoyl-l-homoserine lactone (C6-HSL) induced C. violaceum CV026 cultures at sub-inhibitory concentrations .

HY-N15496

Fusaproliferin FUS	Structural Classification Microorganisms Terpenoids Sesquiterpenes Source classification	Reactive Oxygen Species (ROS) NO Synthase Interleukin Related TNF Receptor p38 MAPK ERK IKK NF-κB
Fusaproliferin is a sesterterpene mycotoxin isolated from Fusarium solani. Fusaproliferin reverse Lipopolysaccharides (HY-D1056) stimulation and the NF-κB and MAPKs signaling pathways contribute to the anti-inflammatory process. Fusaproliferin exhibits affinity for the TLR4 protein with K_D values of 28.6 μM. Fusaproliferin shows cytotoxicity against pancreatic cancer cell with rapid and sub-micromolar IC₅₀ .

HY-W011370

Pelargonidin chloride 1 Publications Verification	Structural Classification Anthocyans Flavonoids Classification of Application Fields Leguminosae Source classification Other Diseases Phenols Polyphenols Plants Phaseolus vulgaris Linn. Disease Research Fields	Quinone Reductase Reactive Oxygen Species (ROS)
Pelargonidin chloride is an anthocyanidin and also is a scavenger of nitric oxide radical and has antioxidant activities. Pelargonidin inhibits cell viability and induces cell cycle arrest at sub-G1 phase. Pelargonidin chloride increases the mRNA and protein expression of HO-1, NQO1, Nrf2. Pelargonidin chloride improves Aβ-induced memory and learning impairment .

HY-P2274R

Argifin (Standard)	Structural Classification Natural Products Microorganisms Source classification	Reference Standards Parasite
Argifin (Standard) is the analytical standard of Argifin. This product is intended for research and analytical applications. Argifin is a sub-nanomolar chitinase inhibitor produced by soil microorganisms, with IC50s of 0.025 μM, 6.4 μM , 1.1 μM and 4.5 μM for SmChiA (Serratia marcescens chitinaese A), SmChiB, Aspergillus fumigatus chitinase B1 and human chitotriosidase, respectively[1].

HY-N0662R

Amentoflavone (Standard) Didemethyl-ginkgetin (Standard)	Structural Classification Flavonoids Source classification Phenols Polyphenols Selaginellaceae Plants Biflavones Selaginella tamariscina (P. Beauv.) Spring	Reference Standards Reactive Oxygen Species (ROS) Apoptosis Bacterial Fungal RSV GABA Receptor
Amentoflavone (Standard) is the analytical standard of Amentoflavone. This product is intended for research and analytical applications. Amentoflavone (Didemethyl-ginkgetin) is a potent and orally active GABA(A) negative modulator. Amentoflavone also shows anti-inflammatory, antioxidative, anti-viral, anti-tumor, anti-radiation, anti-fungal, antibacterial activity. Amentoflavone induces apoptosis and cell cycle arrest at sub-G1 phase .

HY-B0504S

Creatinine-d3 5 Publications Verification NSC13123-d<sub>3sub>	Classification of Application Fields Metabolic Disease Disease Research Fields	Isotope-Labeled Compounds Endogenous Metabolite
Creatinine-d₃ is a deuterium labeled Creatinine. Creatinine is a break-down product of creatine phosphate in muscle .

Cat. No.	Product Name	Chemical Structure

HY-W742417

Tazarotenic acid-d8
Tazarotenic acid-d₈ (AGN 190299-d₈) is the deuterium labeled Tazarotenic acid (HY-101108). Tazarotenic acid is the metabolite of Tazarotene (HY-15388) .

HY-14605S

Rasagiline-13C3 mesylate
Rasagiline- ¹³C₃ ((R)-AGN1135- ¹³C₃; TVP1012- ¹³C₃) mesylate is the deuterium labeled Rasagiline (mesylate) (HY-14605) . Rasagiline (R-AGN1135) mesylate is a highly potent selective irreversible mitochondrial monoamine oxidase (MAO) inhibitor with IC₅₀s of 4.43 nM and 412 nM for rat brain MAO B and A activity, respectively .

HY-U00449S

AGN 193109-d7
AGN 193109-d₇ is the deuterium labeled AGN 193109. AGN 193109 is a retinoid analog, and acts as a specific and highly effective antagonist of retinoic acid receptors (RARs), with Kds of 2 nM, 2 nM, and 3 nM for RARα, RARβ, and RARγ, respectively.

HY-15388S3

Tazarotene-d6
Tazarotene-d₆ (AGN 190168-d₆) is deuterium labeled Tazarotene. Tazarotene (AGN 190168) is a selective retinoic acid receptor (RAR) agonist for the treatment of plaque psoriasis and acne vulgaris. Tazarotene is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-15388S

Tazarotene-d8
Tazarotene-d₈ is the deuterium labeled Tazarotene. Tazarotene (AGN 190168) is a selective retinoic acid receptor (RAR) agonist for the treatment of plaque psoriasis and acne vulgaris .

HY-15388S2

Tazarotene-13C6
Tazarotene- ¹³C₆ (AGN 190168- ¹³C₆) is ¹³C labeled Tazarotene. Tazarotene (AGN 190168) is a selective retinoic acid receptor (RAR) agonist for the treatment of plaque psoriasis and acne vulgaris. Tazarotene is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-15388S1

Tazarotene-13C2,d2

Tazarotene-13C2,d2 (AGN 190168-13C2,d2) is the ¹³C and deuterium labeled isotope of Tazarotene (HY-15388). Tazarotene (AGN 190168) is a selective retinoic acid receptor (RAR) agonist for the treatment of plaque psoriasis and acne vulgaris. Tazarotene is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups .

HY-10844S1

Pretomanid-d5
Pretomanid-d₅ is deuterated labeled Pretomanid (HY-10844). Pretomanid (PA-824) is an antibiotic used for the research of multi-drug-resistant tuberculosis affecting the lungs. Pretomanid exhibits a sub-micromolar MIC against M. tuberculosis (MTB). The MIC values of PA-824 against a panel of MTB pan-sensitive and Rifampin mono-resistant clinical isolates range from 0.015 to 0.25 μg/mL.

HY-101108S1

Tazarotenic acid-13C2,d2
Tazarotenic acid-13C2,d2 (AGN 190299-13C2,d2) is the ¹³C and deuterium labeled isotope of Tazarotenic acid (HY-101108). Tazarotenic acid is the metabolite of Tazarotene. Tazarotenic acid binding to retinoic acid receptors (RARs) is the probable molecular target of retinoid action. Tazarotenic acid has the potential for the research of warty dyskeratoma .

HY-B0191AS

5,6-trans-Bimatoprost-d5
5,6-trans-Bimatoprost-d₅ (5,6-trans-AGN 192024-d₅) is the deuterium labeled 5,6-trans-Bimatoprost (HY-B0191A). 5,6-trans-Bimatoprost is the isomer of Bimatoprost (HY-B0191), and can be used as an experimental control. Bimatoprost is a prostaglandin analogue that can be used in studies of ocular hypertension and glaucoma and also has anti-fat formation effects.

HY-W719338

Pentane-1,2-diol-d7
Pentane-1,2-diol-d₇ ((±)-Pentane-1,2-diol-d₇; 1,2-Dihydroxypentane-d₇; 1,2-Pentylene glycol-d₇; Diol PD-d₇; Hydrolite 5-d₇; NSC 513-d₇; 1,2-Pentanediol-d₇) is the deuterium labeled Pentane-1,2-diol (HY-Y1249).

HY-107327S

Carazolol-d7
Carazolol-d₇ is the deuterium labeled Carazolol (HY-107327). Carazolol is a highly potent antagonist of β₁/β₂ adrenoceptor. Carazolol is also a potent, selective β₃-adrenoceptor agonist. Carazolol can be used in the research of hypertension .

HY-N0006S

Demethoxycurcumin-d7
Demethoxycurcumin-d₇ is the deuterium labeled Demethoxycurcumin. Demethoxycurcumin(Curcumin II), a major active curcuminoid, possess anti-inflammatory properties; also exert cytotoxic effects in human cancer cells via induction of apoptosis.

HY-B0584S2

Travoprost-d7
Travoprost-d₇ (Fluprostenol isopropyl ester-d₇) is deuterium labeled Travoprost. Travoprost (Fluprostenol isopropyl ester), an isopropyl ester proagent, is a high affinity, selective FP prostaglandin full receptor agonist. Travoprost has the ocular hypotensive efficacy and has the potential for glaucoma and ocular hypertension .

HY-B0389S6

D-Glucose-d7
D-Glucose-d₇7 is the deuterium labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response .

HY-66005S2

Acetaminophen-d7
Acetaminophen-d₇ is the deuterium labeled Acetaminophen. Acetaminophen (Paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 25.8 μM; is a widely used antipyretic and analgesic agent. Acetaminophen is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor.

HY-D0711S2

Indocyanine green-d7
Indocyanine green-d7 (Foxgreen-d7) is the deuterium labeled Indocyanine green (HY-D0711). Indocyanine green is a low toxicic fluorescent agent that has been widely used in medical diagnostics, such as determining cardiac output, hepatic function, and liver blood flow, and for ophthalmic angiography .

HY-107352S

Fosfenopril-d7
Fosfenopril-d₇ is deuterium labeled Fosfenopril.

HY-N7101S

Cefpodoxime proxetil-d7

Cefpodoxime proxetil-d₇ (U-76-d₇,252-d₇; CS-807-d₇) is the deuterium labeled Cefpodoxime Proxetil (HY-N7101). Cefpodoxime Proxetil is an orally active broad spectrum third-generation cephalosporin with potent antibacterial activity against both Gram-positive and Gram-negative bacteria including staphylococci, streptococci, Haemophilus influenzae, Neisseria gonorrhoeae, Escherichia coli, Klebsiella pnuemoniae, Citrobacter spp, and Proteus spp. Cefpodoxime Proxetil binds to penicillin binding proteins (PBPs), which inhibits peptidoglycan synthesis, finally results in interfering bacterial cell wall biosynthesis. Cefpodoxime Proxetil can be used against skin structure infections, acute otitis media, pharyngitis, tonsillitis, upper respiratory tract infection, urinary tract infections and sexually transmitted diseases .

HY-12057S1

Vemurafenib-d7
Vemurafenib-d₇ is deuterium labeled Vemurafenib. Vemurafenib (PLX4032) is a first-in-class, selective, potent inhibitor of B-RAF kinase, with IC₅₀s of 31 and 48 nM for RAFV600E and c-RAF-1, respectively . Vemurafenib induces cell autophagy .

HY-15149S2

Romidepsin-d7

Romidepsin-d₇ (FK 228-d₇) is deuterium labeled Romidepsin. Romidepsin (FK 228) is a Histone deacetylase (HDAC) inhibitor with anti-tumor activities. Romidepsin (FK 228) inhibits HDAC1, HDAC2, HDAC4, and HDAC6 with IC₅₀s of 36 nM, 47 nM, 510 nM and 1.4 μM, respectively . Romidepsin (FK 228) is produced by Chromobacterium violaceum, induces cell G2/M phase arrest and apoptosis .

HY-B1548S

Benznidazole-d7
Benznidazole-d₇ (Benznidazol-d₇; Ro 07-1051-d₇; Ro 71051-d₇) is the deuterium labeled Benznidazole (HY-B1548). Benznidazole (Ro 07-1051) is an antiparasitic medication, with an IC₅₀ of 20.35 μM for Colombian T. cruzi strains, and has been used in the treatment of Chagas disease .

HY-15027S4

5-Aminosalicylic acid-d7
5-Aminosalicylic acid-d₇ (5-ASA-d₇; Mesalamie-d₇; Mesalazie-d₇) is deuterium labeled 5-Aminosalicylic Acid. 5-Aminosalicylic acid (Mesalamine) acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB. 5-Aminosalicylic acid can inhibit the activity of osteopontin (OPN) .

HY-W653985

Cortodoxone-d7
Cortodoxone-d₇ (11-Deoxycortisol-d₇) is a deuterium labeled Cortodoxone (HY-77839). Cortodoxone (11-Deoxycortisol; cortexolone) is a glucocorticoid steroid hormone and also is a glucocorticoid antagonist. Cortodoxone increases tryptophan oxygenase (TO) activity and induces the secretion of corticosterone. Cortodoxone regulates T cell proliferation and activation .

HY-Y1309S1

1-Naphthol-d7
1-Naphthol-d7 is the deuterium labeled Naphthol .

HY-N7745S

Glucosylsphingosine-d7
Glucosylsphingosine-d₇ is deuterium labeled Glucosylsphingosine.

HY-B0191S

Bimatoprost-d5
Bimatoprost-d₅ is a deuterium labeled Bimatoprost. Bimatoprost is a prostaglandin analog and is a topical hypotensive agent frequently used for treating ocular hypertension and glaucoma. Bimatoprost also has an antiadipogenic effect .

HY-41700S3

D-Alanine-d7
D-Alanine-d₇ is the deuterium labeled D-Alanine. D-Alanine is a weak GlyR (inhibitory glycine receptor) and PMBA agonist, with an EC50 of 9 mM for GlyR.

HY-W778920

5α-Cholestan-3β-ol-d7
5α-Cholestan-3β-ol-d₇ (Dihydrocholesterol-d₇; 5α-Cholestanol-d₇; NSC 18188-d₇) is the deuterium labeled 5α-Cholestan-3β-ol (HY-107819). 5α-Cholestan-3β-ol is a derivitized steroid compound.

HY-N2334AS

Glycochenodeoxycholic acid-d7 sodium

Glycochenodeoxycholic acid-d₇ (sodium) is the deuterium labeled Glycochenodeoxycholic acid (sodium salt). Glycochenodeoxycholic acid sodium salt (Chenodeoxycholylglycine sodium salt) is a bile acid formed in the liver from chenodeoxycholate and glycine. It acts as a detergent to solubilize fats for absorption and is itself absorbed. Glycochenodeoxycholic acid sodium salt (Chenodeoxycholylglycine sodium salt) induces hepatocyte apoptosis .

HY-135328S

Norverapamil-d7
Norverapamil-d₇ is a deuterium labeled Norverapamil ((±)-Norverapamil). Norverapamil, an N-demethylated metabolite of Verapamil, is a L-type calcium channel blocker and a P-glycoprotein (P-gp) function inhibitor .

HY-135328AS

Norverapamil-d7 hydrochloride
Norverapamil-d₇ (hydrochloride) is a deuterium labeled Norverapamil. Norverapamil ((±)-Norverapamil), an N-demethylated metabolite of Verapamil, is a L-type calcium channel blocker and a P-glycoprotein (P-gp) function inhibitor .

HY-107370S

Atomoxetine-d7

Atomoxetine-d₇ (Tomoxetine-d₇) is deuterium labeled Atomoxetine. Atomoxetine (Tomoxetine) is a selective noradrenaline reuptake inhibitor with K_i values of 5, 77 and 1451 nM for norepinephrine (NE), serotonin (5-HT) and dopamine (DA) transporters, respectively. Atomoxetine (Tomoxetine) increases of DA_EX and NE_EX in the PFC and enhances catecholaminergic neurotransmission. Atomoxetine (Tomoxetine) is a potent Na ⁺ channels (VGSCs) blocker. Atomoxetine (Tomoxetine) can be used for attention-deficit hyperactivity disorder (ADHD) research .

HY-B1438S2

Canrenone-d7
Canrenone-d₇ (Aldadiene-d₇ ) is deuterium labeled Canrenone. Canrenone (Aldadiene) is an aldosterone antagonist extensively used as a diuretic agent.

HY-17025S

Rifabutin-d7
Rifabutin-d₇ is the deuterium labeled Rifabutin. Rifabutin (Ansamycin) is a semisynthetic ansamycin antibiotic with potent antimycobacterial properties. Rifabutin inhibits DNA-dependent RNA polymerase.

HY-107855S

DL-Mevalonolactone-d7
DL-Mevalonolactone-d₇ is the deuterium labeled DL-Mevalonolactone. DL-Mevalonolactone ((±)-Mevalonolactone) is the δ-lactone form of mevalonic acid, a precursor in the mevalonate pathway. DL-Mevalonolactone (Mevalonolactone) decreases mitochondrial membrane potential (?Ψm), NAD(P)H content and the capacity to retain Ca2+ in the brain, besides inducing mitochondrial swelling .

HY-109037S4

Mavacamten-d7
Mavacamten-d₇ (MYK461-d₇) is deuterium labeled Mavacamten. Mavacamten (MYK461) is an orally active modulator of cardiac myosin, with IC₅₀s of 490, 711 nM for bovine cardiac and human cardiac, respectively.

HY-B0391S2

Naftopidil-d7
Naftopidil-d₇ (KT-611-d₇ ) is deuterium labeled Naftopidil. Naftopidil (KT-611) is is a selective alpha1-adrenoceptor antagonist, with K_is of 3.7 nM, 20 nM and 1.2 nM for the cloned human α_1a-, α_1b- and α_1d-adrenoceptor subtypes, respectively. Naftopidil has antiproliferative effects. Naftopidil can be used for the research of prostate hyperplasia .

HY-N0650S11

L-Serine-d7
L-Serine-d₇ is the deuterium labeled L-Serine. L-Serine ((-)-Serine; (S)-Serine), one of the so-called non-essential amino acids, plays a central role in cellular proliferation.

HY-50898S4

Lapatinib-d7
Lapatinib-d₇ (GW572016-d₇) is deuterium labeled Lapatinib. Lapatinib (GW572016) is a potent inhibitor of the ErbB-2 and EGFR tyrosine kinase domains with IC₅₀ values against purified EGFR and ErbB-2 of 10.2 and 9.8 nM, respectively .

HY-30237S

(R)-Roscovitine-d7
(R)-Roscovitine-d₇ (Seliciclib-d₇; CYC202-d₇) is deuterium-labeled (R)-Roscovitine (HY-30237) .

HY-15662S

Tulathromycin A-d7
Tulathromycin A-d₇ (Tulathromycin-d₇) is deuterium labeled Tulathromycin A. Tulathromycin A (Tulathromycin), a macrolide antibiotic, inhibits protein synthesis (IC₅₀=0.26 μM) by targeting bacterial ribosome. Tulathromycin A is used for the research of respiratory disease in cattle and swine. Immunomodulatory effects .

HY-B1674S4

(±)-Leucine-d7
(±)-Leucine-d₇ is the deuterium labeled (±)-Leucine. (±)-Leucine (DL-Leucine), an isomer of Leucine, chemosterilant and dietary additive. (±)-Leucine inhibits growth of Escherichia coli HfrH by 92.08% .

HY-B0202S3

Irbesartan-d7
Irbesartan-d₇ is deuterated labeled Irbesartan (HY-B0202). Irbesartan (SR-47436) is an orally active Ang II type 1 (AT1) receptor blocker (ARB). Irbesartan can relax the blood vessels, low blood pressure and increase the supply of blood and oxygen to the heart. Irbesartan can be used for the research of high blood pressure, heart failure, and diabetic kidney disease .

HY-12296S

Navtemadlin-d7
Navtemadlin-d₇ is the deuterium labeled Navtemadlin. Navtemadlin (AMG 232) is a potent, selective and orally available inhibitor of p53-MDM2 interaction, with an IC₅₀ of 0.6 nM. Navtemadlin binds to MDM2 with a Kd of 0.045 nM .

HY-135853S

Molnupiravir-d7

Molnupiravir-d₇ is the deuterium labeled Molnupiravir. Molnupiravir (EIDD-2801) is an orally bioavailable prodrug of the ribonucleoside analog EIDD-1931. Molnupiravir has broad spectrum antiviral activity against influenza virus and multiple coronaviruses, such as SARS-CoV-2, MERS-CoV, SARS-CoV. Molnupiravir has the potential for the research of COVID-19, and seasonal and pandemic influenza .

HY-13720AS

Pergolide-d7 mesylate
Pergolide-d₇ (mesylate) is the deuterium labeled Pergolide mesylate. Pergolide mesylate (Pergolide methanesulfonate), an Ergoline derivative, is a potent and orally active dopamine D1 and D2 receptors agonist. Pergolide mesylate can be used for Parkinson's disease and hyperprolactinaemia research .

HY-50898S1

Lapatinib-d7 dihydrochloride
Lapatinib-d₇ dihydrochloride is the deuterium labeled Lapatinib dihydrochloride. Lapatinib (GW572016) dihydrochloride is a potent inhibitor of the ErbB-2 and EGFR tyrosine kinase domains with IC₅₀ values against purified EGFR and ErbB-2 of 10.2 and 9.8 nM, respectively .

HY-14268S1

Febuxostat-d7
Febuxostat-d₇ is deuterium labeled Febuxostat. Febuxostat (TEI 6720) is selective xanthine oxidase inhibitor with a K_i of 0.6 nM .

HY-B0679S

Lubiprostone-d7

Lubiprostone-d₇ (RU-0211-d7) is the deuterium labeled Lubiprostone. Lubiprostone (SPI-0211) increases intestinal fluid secretion through generation of CIC-2/CFTR and activation of cAMP signaling pathway. Lubiprostone inhibits myeloperoxidase (MPO) activity, downregulates Indomethacin (HY-14397)-induced iNOS and TNFα expression. Lubiprostone can be used for chronic constipation research .

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks