Search Result

Results for "

| facial skin blemishes

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (7) Acyltransferase (1) Adrenergic Receptor (7) Akt (6) Amino Acid Derivatives (3) AMPK (2) Amyloid-β (1) Androgen Receptor (3) Angiotensin Receptor (3) Angiotensin-converting Enzyme (ACE) (1) Annexin A (1) Antibiotic (89) Antibody-Drug Conjugates (ADCs) (1) AP-1 (1) Apoptosis (64) Aryl Hydrocarbon Receptor (8) Atg8/LC3 (1) Aurora Kinase (1) Autophagy (15) Bacterial (175) Beta-lactamase (7) Biochemical Assay Reagents (91) Bombesin Receptor (1) c-Kit (1) Calcium Channel (5) Cannabinoid Receptor (3) Casein Kinase (1) Caspase (9) Cathepsin (1) CCR (1) Cdc42-binding kinase (1) CDK (2) CFTR (2) CGRP Receptor (1) Cholinesterase (ChE) (1) Collagen (3) COX (18) CRFR (2) Cytochrome P450 (7) Dengue Virus (1) DNA Alkylator/Crosslinker (2) DNA Methyltransferase (1) DNA/RNA Synthesis (15) Dopamine Receptor (2) Drug Derivative (7) Drug Intermediate (6) Drug Metabolite (8) EBV (1) EGFR (2) Elastase (1) Endogenous Metabolite (59) Enterovirus (3) ERK (4) Estrogen Receptor/ERR (11) Eukaryotic Initiation Factor (eIF) (1) FAK (2) Fatty Acid Synthase (FASN) (1) Ferroptosis (7) Filovirus (3) FKBP (2) Fluorescent Dye (2) Free Fatty Acid Receptor (3) Fungal (51) Glucocorticoid Receptor (24) Glucosylceramide Synthase (GCS) (2) Glutathione Peroxidase (1) Glutathione S-transferase (1) Glycosidase (1) GSK-3 (2) HBV (2) HCV (2) HDAC (3) HIF/HIF Prolyl-Hydroxylase (1) Histamine Receptor (19) HIV (5) HPV (1) HSP (5) HSV (2) IFNAR (4) Imidazoline Receptor (3) Influenza Virus (4) Integrin (1) Interleukin Related (25) IRAK (2) Isotope-Labeled Compounds (38) JAK (12) JNK (3) Keap1-Nrf2 (3) Leukotriene Receptor (2) Lipase (2) Liposome (5) Lipoxygenase (4) LPL Receptor (1) LRRK2 (1) LXR (1) MAP3K (2) MAPKAPK2 (MK2) (1) Mas-related G-protein-coupled Receptor (MRGPR) (6) MDM-2/p53 (2) MEK (3) Melanocortin Receptor (10) mGluR (1) Mitochondrial Metabolism (3) Mitophagy (2) MMP (20) Monoamine Oxidase (6) Monocarboxylate Transporter (1) mTOR (2) Na+/K+ ATPase (3) Necroptosis (1) Neurokinin Receptor (2) Neuropeptide Y Receptor (1) Neurotensin Receptor (2) NF-κB (13) NO Synthase (6) NOD-like Receptor (NLR) (1) Opioid Receptor (6) Organoid (1) P-glycoprotein (1) P2X Receptor (1) p38 MAPK (9) Parasite (20) PARP (4) PD-1/PD-L1 (1) Penicillin-binding protein (PBP) (10) PERK (2) PGC-1α (1) PGE synthase (1) Phosphatase (3) Phosphodiesterase (PDE) (3) Photosensitizer (5) Photosystem II (3) PI3K (8) PKA (3) PKC (5) Potassium Channel (2) PPAR (4) Procollagen C Proteinase (1) Prostaglandin Receptor (3) PROTACs (1) Pyroptosis (2) Raf (2) RAR/RXR (10) Ras (2) Reactive Oxygen Species (ROS) (21) Reference Standards (16) ROCK (1) ROR (3) Sigma Receptor (1) Sirtuin (2) Smo (2) SOD (2) Sodium Channel (5) SphK (1) Src (1) STAT (4) Stearoyl-CoA Desaturase (SCD) (2) Syk (1) TGF-beta/Smad (2) TGF-β Receptor (3) Thymidylate Synthase (1) Thyroid Hormone Receptor (1) TNF Receptor (3) Toll-like Receptor (TLR) (1) TOPK (4) Topoisomerase (2) TRP Channel (5) TSH Receptor (1) Tyrosinase (30) VD/VDR (3) VEGFR (2) Virus Protease (1) Wnt (3) YAP (1) β-catenin (3)
By Research Areas:	Cancer (189) Cardiovascular Disease (35) Endocrinology (39) Infection (233) Inflammation/Immunology (263) Metabolic Disease (61) Neurological Disease (65)
Click Chemistry:	Alkynes (2)
Oligonucleotides:	Solvents (1) Thickeners (1) Liposomal Film-forming Agents (1) Disintegrants (1) Suspending Agents (1) Emulsifiers (3) Phospholipids (1) Bases (1) Antisense Oligonucleotides (2)

774

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

128

Peptides

Inhibitory Antibodies

162

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0633C

Hyaluronic acid (Mw:1000-2000Da)	Biochemical Assay Reagents Interleukin Related Atg8/LC3	Inflammation/Immunology
Hyaluronic acid (Mw:1000-2000Da) is a long-chain, unbranched polysaccharide with a molecular weight of 1000-2000 Dalton. Hyaluronic acid (Mw:1000-2000Da) regulates tissue homeostasis and stress resistance, exhibits a pro-inflammatory effect (while hyaluronic acid with high molecular weight exhibits an anti-inflammatory effect), and promotes angiogenesis and tissue remodeling. Hyaluronic acid (Mw:1000-2000Da) exhibits good biocompatible and biodegradable characteristics, that can be used in drug delivery systems and tissue engineering .

HY-NP101

Highly purified Type I collagen, from bovine skin Bovine Type I collagen, immunization grade	Biochemical Assay Reagents	Inflammation/Immunology
Highly purified Type I collagen, from bovine skin (Bovine Type I collagen, immunization grade) plays an important role in the structure and function of skin, bone, tendons, and many others. Type I collagen potently stimulates angiogenesis in vitro and in vivo. Highly purified Type I collagen, from bovine skin is an immunization grade that can be used for immunization to generate antibodies .

HY-NP175

*Collagen (bovine skin)*	Biochemical Assay Reagents	Others
Collagen (bovine skin) plays an important role in the structure and function of skin, bone, tendons, and many others. Collagen, from bovine skin can be used to provide a scaffold for biomimetic collagen mineralization .

HY-N13232

*Grape Skin* Extract**	Amyloid-β	Neurological Disease
Grape Skin Extract is a grape skin extract, and its ingredients include: Polyphenols. Grape Skin Extract has neuroprotective effects and can improve Aβ-induced cytotoxicity to SH-SY5Y cells. Grape Skin Extract can increase the proliferation and memory of neurogenic areas, but reduce the oxidative stress associated with proinflammatory cytokines during aging, thereby protecting neurons. .

HY-P5890

YVAD-CHO	Interleukin Related Caspase	Neurological Disease
YVAD-CHO is an interleukin-1β converting enzyme (ICE, caspase 1) inhibitor that can partially delay motoneurone death in lesioned facial nerve mice .

HY-Y1365L

*Porcine skin* Gelatin,suitable for cell culture(high gel strength)**	Biochemical Assay Reagents	Others
Porcine skin Gelatin,suitable for cell culture(high gel strength) 可用于包被细胞以改善细胞的附着。

HY-Y1365E

*Porcine skin* Gelatin,suitable for cell culture(medium gel strength)**	Biochemical Assay Reagents	Others
Porcine skin Gelatin,suitable for cell culture (medium gel strength) 可用于包被细胞以改善细胞的附着。

HY-N15152

Isoaesculioside D	Others	Metabolic Disease
Isoaesculioside D (compound 3) is an agent for preventing or ameliorating skin aging. Isoaesculioside D exhibits an excellent effect on the suppression of formation, or the amelioration, of wrinkles on the skin or sagging skin .

HY-P5263

YYRADDA	MMP	Others
YYRADDA is a polypeptide. YYRADDA stimulates the growth of collagen in the extracellular matrix of the skin. YYRADDA improves the appearance of the skin and promotes the healing of damaged skin .

HY-NP127

Highly purified Type I collagen, from canine skin Canine Type I collagen, immunization grade	MMP	Inflammation/Immunology
Highly purified Type I collagen, from canine skin (Canine Type I collagen, immunization grade) is an immune grade collagen derived from canine skin, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .

HY-NP122

Highly purified Type I collagen, from porcine skin Porcine Type I collagen, immunization grade	MMP	Inflammation/Immunology
Highly purified Type I collagen, from porcine skin (Porcine Type I collagen, immunization grade) is an immune grade collagen derived from porcine skin, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .

HY-NP124

Highly purified Type III collagen, from porcine skin Porcine Type III collagen, immunization grade	MMP	Inflammation/Immunology
Highly purified Type III collagen, from porcine skin (Porcine Type III collagen, immunization grade) is an immune grade collagen derived from porcine skin, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .

HY-NP128

Highly purified Type I collagen, from rabbit skin Rabbit Type I collagen, immunization grade	MMP	Inflammation/Immunology
Highly purified Type I collagen, from rabbit skin (Canine Type I collagen, immunization grade) is an immune grade collagen derived from rabbit skin, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .

HY-NP103

Highly purified Type III collagen, from bovine skin Bovine Type III collagen, immunization grade	MMP	Inflammation/Immunology
Highly purified Type III collagen, from bovine skin (Bovine Type III collagen, immunization grade) is an immune grade collagen derived from bovine skin, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .

HY-NP107

Highly purified Type I collagen, from rat skin Rat Type I collagen, immunization grade	MMP	Inflammation/Immunology
Highly purified Type I collagen, from rat skin (Rat Type I collagen, immunization grade) is an immune grade collagen derived from rat skin, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .

HY-NP109

Highly purified type I collagen, from mouse skin Mouse Type I collagen, immunization grade	MMP	Inflammation/Immunology
Highly purified type I collagen, from mouse skin (Mouse Type I collagen, immunization grade) is an immune grade collagen derived from mouse skin, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .

HY-NP112

Highly purified Type I collagen, from chick skin Chick type I collagen, immunization grade	MMP	Inflammation/Immunology
Highly purified Type I collagen, from chick skin (Chick type I collagen, immunization grade) is an immune grade collagen derived from chick skin, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .

HY-P0045

Palmitoyl pentapeptide 4 Matrixyl; Palmitoyl pentapeptide 3; Matrixyl (Palmitoyl Pentapeptide)	Collagen	Others
Palmitoyl pentapeptide 4 (Matrixyl; Palmitoyl pentapeptide 3; Matrixyl (Palmitoyl Pentapeptide) is a bioactive peptide with anti-ageing effect and has been reported used as a cosmetic ingredient ^[1]

HY-N10496

Sericoside	Others	Inflammation/Immunology
Sericoside is a triterpenoid with anti-inflammatory activity, can be isolated form Terminalia. Sericoside has a strong lipolytic activity. Sericoside can also reduce skin wrinkles and ameliorating skin texture .

HY-125920

Lauroylsarcosine sodium Sarkosyl NL sodium	Biochemical Assay Reagents	Others
Lauroylsarcosine sodium is a surfactant commonly used in personal care and cosmetics such as shampoos, facial cleansers and toothpaste. It works by lowering the surface tension of water, allowing it to better penetrate and clean surfaces. Lauroylsarcosine sodium is considered safe for cosmetic use and is approved for use in several countries. However, it can cause skin irritation in high concentrations or with prolonged exposure.

HY-U00058

Diflucortolone valerate	Fungal Bacterial	Infection Inflammation/Immunology
Diflucortolone valerate is a powerful corticosteroid used topically for the research of various skin diseases .

HY-133027

Myristyl nicotinate Tetradecyl nicotinate	Biochemical Assay Reagents	Cancer
Myristyl nicotinate (Tetradecyl nicotinate) is an ester proagent and a lipophilic derivative of Nicotinic acid. Myristyl nicotinate is being developed for delivery of Nicotinic acid into the skin for prevention of actinic keratosis and its progression to skin cancer. Myristyl nicotinate shows to stimulate epidermal differentiation in photodamaged skin, increasing skin NAD content and strengthening the skin barrier .

HY-157418

1-Deoxy-Cer	Others	Others
1-Deoxy-Cer is a Ceramide which is essential component of the skin permeability barrier.

HY-W009051

Decamethylcyclopentasiloxane	Biochemical Assay Reagents	Others
Decamethylcyclopentasiloxane (D5), an organosilicon compound that is used as a skin emollient in cosmetics and personal products .

HY-W040996

2-Octyldodecanol	Others	Others
2-Octyldodecanol can enhance the skin permeation of formoterol fumarate (HY-B0010) .

HY-164066

Sodium Acetylated Hyaluronate	Biochemical Assay Reagents	Others
Sodium Acetylated Hyaluronate is an acetylated hyaluronic acid derivative with anti-wrinkle and deep skin penetration properties, which can be used in skin aging research and cosmetic development .

HY-169328

Tyrosinase-IN-39	Tyrosinase	Metabolic Disease
Tyrosinase-IN-39 (compound 5r) is a competitive tyrosinase inhibitor with the IC₅₀ of 6.4 μM and can be used for study of skin diseases .

HY-133027R

Myristyl nicotinate (Standard)	Biochemical Assay Reagents	Cancer
Myristyl nicotinate (Standard) is the analytical standard of Myristyl nicotinate. This product is intended for research and analytical applications. Myristyl nicotinate (Tetradecyl nicotinate) is an ester proagent and a lipophilic derivative of Nicotinic acid. Myristyl nicotinate is being developed for delivery of Nicotinic acid into the skin for prevention of actinic keratosis and its progression to skin cancer. Myristyl nicotinate shows to stimulate epidermal differentiation in photodamaged skin, increasing skin NAD content and strengthening the skin barrier .

HY-125920R

Lauroylsarcosine sodium (Standard) Sarkosyl NL sodium (Standard)	Biochemical Assay Reagents	Others
Lauroylsarcosine (sodium) (Standard) is the analytical standard of Lauroylsarcosine (sodium). This product is intended for research and analytical applications. Lauroylsarcosine sodium is a surfactant commonly used in personal care and cosmetics such as shampoos, facial cleansers and toothpaste. It works by lowering the surface tension of water, allowing it to better penetrate and clean surfaces. Lauroylsarcosine sodium is considered safe for cosmetic use and is approved for use in several countries. However, it can cause skin irritation in high concentrations or with prolonged exposure.

HY-132818

Idrevloride P-1037	Sodium Channel	Others
Idrevloride, an epithelial sodium channel (ENaC) inhibitor (WO2016133967), can be used for the research of skin disorders .

HY-12538

Graveoline Rutamine	Apoptosis Autophagy Fungal	Infection Cancer
Graveoline (Rutamine) is an anti-cancer agent that can trigger apoptosis and autophagy in skin melanoma cells. Graveoline also exhibits antifungal activity .

HY-121069

Elubiol Dichlorophenyl imidazoldioxolan	Fungal	Others
Elubiol (Dichlorophenyl imidazoldioxolan) has moderate sebum-inhibiting activity and can be used in the treatment of oily skin or dandruff .

HY-W010056

Diethyl fumarate 1 Publications Verification	Biochemical Assay Reagents	Neurological Disease Inflammation/Immunology
Diethyl fumarate is a decomposition product of Malathion 9 (a pesticide) and reactant in the Diels-Alder reaction. Diethyl fumarate is a reputed skin irritant. Diethyl fumarate can causes non-immunologic contact urticaria on skin. Diethyl fumarate and Curcumin (HY-N0005) hybridize to exert neuroprotective effects .

HY-N10337

Norjuziphine (-)-Norjuziphine	Drug Derivative	Cancer
Norjuziphine ((-)-Norjuziphine) is an alkaloid found in the lotus flower (Nelumbo nucifera). Norjuziphine inhibits the melanogenesis of murine B16 melanoma 4A5 cells stimulated by Theophylline (HY-B0809) (IC₅₀=14.4 μM). Norjuziphine is promising for research of skin whitening and related skin pigmentation diseases .

HY-106647

Abacavir hydroxyacetate	Interleukin Related	Inflammation/Immunology
Abacavir hydroxyacetate is an orally active inhibitor of IL-20 and PRINS. Abacavir hydroxyacetate reduces proliferation rate of skin in psoriasis as an immune modulator. Abacavir hydroxyacetate can be used for the research of inflammatory skin problems .

HY-W009051R

Decamethylcyclopentasiloxane (Standard)	Biochemical Assay Reagents	Others
Decamethylcyclopentasiloxane (Standard) is the analytical standard of Decamethylcyclopentasiloxane. This product is intended for research and analytical applications. Decamethylcyclopentasiloxane (D5), an organosilicon compound that is used as a skin emollient in cosmetics and personal products .

HY-112809

GSK2646264	Syk Src LRRK2 GSK-3 JAK VEGFR Aurora Kinase	Inflammation/Immunology
GSK2646264 (Compound 44) is a potent and selective spleen tyrosine kinase (SYK) inhibitor with a pIC₅₀ of 7.1. GSK2646264 also inhibits other kinases with pIC₅₀ values of 5.4, 5.4, 5.3, 5, 4.5, <4.6 and <4.3 against LCK, LRRK2, GSK3β, JAK2, VEGFR2, Aurora B and Aurora A, respectively. GSK2646264 is penetrable into the epidermis and dermis of the skin .

HY-173512

mTYR-IN-1	Tyrosinase	Metabolic Disease
mTYR-IN-1 (compound 3e) is a reversible and competitive mTYR inhibitor with an IC₅₀ of 4.86 μM. mTYR-IN-1 can be used in the study of skin pigmentation .

HY-P3915

Esculentin 1A	Bacterial	Infection
Esculentin 1A is a frog skin-derived antimicrobial peptide (AMP) with potent in vitro anti-Pseudomonas activity .

HY-P3452

Tetrapeptide-30	Tyrosinase	Inflammation/Immunology
Tetrapeptide-30 is a skin-brightening peptide consisting of four amino acids. Tetrapeptide-30 can act as a tyrosinase inhibitor, lightening hyperpigmentation and evening out skin tone by reducing the amount of tyrosinase and inhibiting melanocyte activation .

HY-P991285

MEDI-9314	Interleukin Related	Inflammation/Immunology
MEDI-9314 is a humanized monoclonal anti-CD124/IL4R/IL-4Rα antibody. MEDI-9314 can be used in research related to skin allergy .

HY-B1365

Prednicarbate	Glucocorticoid Receptor	Inflammation/Immunology
Prednicarbate is a topical corticosteroid agent. Prednicarbate can be used for the research of inflammatory skin diseases, such as atopic dermatitis .

HY-112959

Telavancin TD-6424	Antibiotic Bacterial	Infection
Telavancin (TD-6424) is a semisynthetic lipoglycopeptide vancomycin-derivative, is a novel antimicrobial agent developed by Theravance for overcoming resistant Gram-positive bacterial infections, specifically methicillin-resistant Staphylococcus aureus (MRSA). Telavancin disrupts cell membrane integrity, can be used for research of complicated skin and skin structure infections (cSSSIs) caused by Gram-positive bacteria .

HY-N3002R

α-Arbutin (Standard)	Tyrosinase	Metabolic Disease
α-Arbutin (Standard) is the analytical standard of α-Arbutin. This product is intended for research and analytical applications. α-Arbutin (4-Hydroxyphenyl α-D-glucopyranoside) is emerging as popular and effective skin whiteners, acting as tyrosinase inhibitor .

HY-N7132

Menthyl acetate L-Menthyl acetate; (-)-Menthyl acetate	Others	Others
Menthyl acetate (L-Menthyl acetate) is a derivative of L-menthol. Menthyl acetate is effective to enhance 5-aminolevulinic acid (ALA) skin permeation .

HY-W015300

Suberic acid Octanedioic acid	Endogenous Metabolite Akt TGF-β Receptor p38 MAPK	Metabolic Disease
Suberic acid (Octanedioic acid) is an orally active crystalline dibasic acid. Suberic acid activates the Akt signaling pathway and regulates the expression of molecules related to the TGF-β and MAPK signaling pathways. Suberic acid inhibits skin dryness .

HY-P0095

Acetyl tetrapeptide-5	Angiotensin-converting Enzyme (ACE)	Others
Acetyl tetrapeptide-5 inhibits glycosylation and ACE-1 activity. Acetyl tetrapeptide-5 reduces edema and relieves vascular pressure by improving the vascular system and strengthening the skin under the eyes. Acetyl tetrapeptide-5 can be used in the research of Antioxidant, anti-aging skin care .

HY-30272R

Monobenzone (Standard)	DNA/RNA Synthesis Apoptosis	Inflammation/Immunology
Monobenzone (Standard) is the analytical standard of Monobenzone. This product is intended for research and analytical applications. Monobenzone is a potent skin depigmenting agent. Monobenzone induces depigmentation and active human vitiligo and exhibits good potential for vitiligo research .

HY-W040996R

2-Octyldodecanol (Standard)	Biochemical Assay Reagents	Others
2-Octyldodecanol (Standard) is the analytical standard of 2-Octyldodecanol. This product is intended for research and analytical applications. 2-Octyldodecanol can enhance the skin permeation of formoterol fumarate (HY-B0010) .

HY-12538R

Graveoline (Standard)	Apoptosis Autophagy Fungal	Infection Cancer
Graveoline (Standard) is the analytical standard of Graveoline. This product is intended for research and analytical applications. Graveoline (Rutamine) is an anti-cancer agent that can trigger apoptosis and autophagy in skin melanoma cells. Graveoline also exhibits antifungal activity .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N10496

Sericoside	Triterpenes Terminalia sericea Burch. ex DC. Terpenoids Combretaceae Source classification Plants	Others
Sericoside is a triterpenoid with anti-inflammatory activity, can be isolated form Terminalia. Sericoside has a strong lipolytic activity. Sericoside can also reduce skin wrinkles and ameliorating skin texture .

HY-12538

Graveoline Rutamine	Structural Classification Alkaloids Source classification Ruta graveolens Linn. Rutaceae Quinoline Alkaloids Plants	Apoptosis Autophagy Fungal
Graveoline (Rutamine) is an anti-cancer agent that can trigger apoptosis and autophagy in skin melanoma cells. Graveoline also exhibits antifungal activity .

HY-W010056

Diethyl fumarate 1 Publications Verification	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	Biochemical Assay Reagents
Diethyl fumarate is a decomposition product of Malathion 9 (a pesticide) and reactant in the Diels-Alder reaction. Diethyl fumarate is a reputed skin irritant. Diethyl fumarate can causes non-immunologic contact urticaria on skin. Diethyl fumarate and Curcumin (HY-N0005) hybridize to exert neuroprotective effects .

HY-N7132

Menthyl acetate L-Menthyl acetate; (-)-Menthyl acetate	Structural Classification Natural Products Classification of Application Fields Acacia farnesiana (Linn.) Willd. Labiatae Source classification Other Diseases Plants Disease Research Fields	Others
Menthyl acetate (L-Menthyl acetate) is a derivative of L-menthol. Menthyl acetate is effective to enhance 5-aminolevulinic acid (ALA) skin permeation .

HY-W015300

Suberic acid Octanedioic acid	Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease markers Endocrine diseases Metabolic Disease Endogenous metabolite Disease Research Fields Cardiovascular System Disorder	Endogenous Metabolite Akt TGF-β Receptor p38 MAPK
Suberic acid (Octanedioic acid) is an orally active crystalline dibasic acid. Suberic acid activates the Akt signaling pathway and regulates the expression of molecules related to the TGF-β and MAPK signaling pathways. Suberic acid inhibits skin dryness .

HY-N15152

Isoaesculioside D	Triterpenes Structural Classification Terpenoids Hippocastanaceae Aesculus hippocastanum Source classification Plants	Others
Isoaesculioside D (compound 3) is an agent for preventing or ameliorating skin aging. Isoaesculioside D exhibits an excellent effect on the suppression of formation, or the amelioration, of wrinkles on the skin or sagging skin .

HY-N10337

Norjuziphine (-)-Norjuziphine	Structural Classification Alkaloids Source classification Nelumbo nucifera Gaertn. Quinoline Alkaloids Plants Nymphaeaceae	Drug Derivative
Norjuziphine ((-)-Norjuziphine) is an alkaloid found in the lotus flower (Nelumbo nucifera). Norjuziphine inhibits the melanogenesis of murine B16 melanoma 4A5 cells stimulated by Theophylline (HY-B0809) (IC₅₀=14.4 μM). Norjuziphine is promising for research of skin whitening and related skin pigmentation diseases .

HY-N3002R

α-Arbutin (Standard)	Structural Classification Monophenols Source classification Phenols Ericaceae Plants	Tyrosinase
α-Arbutin (Standard) is the analytical standard of α-Arbutin. This product is intended for research and analytical applications. α-Arbutin (4-Hydroxyphenyl α-D-glucopyranoside) is emerging as popular and effective skin whiteners, acting as tyrosinase inhibitor .

HY-12538R

Graveoline (Standard)	Structural Classification Alkaloids Ruta graveolens Linn. Source classification Rutaceae Quinoline Alkaloids Plants	Apoptosis Autophagy Fungal
Graveoline (Standard) is the analytical standard of Graveoline. This product is intended for research and analytical applications. Graveoline (Rutamine) is an anti-cancer agent that can trigger apoptosis and autophagy in skin melanoma cells. Graveoline also exhibits antifungal activity .

HY-120860

Sporidesmolide I	Structural Classification Microorganisms Cyclopeptides Source classification	Others
Sporidesmolide I can be found in Sporidesmium bakeri. Sporidesmolide I is promising for research into diseases such as mammalian facial eczema .

HY-N14828

Sporidesmin	Structural Classification Natural Products Microorganisms Source classification	Wnt
Sporidesmin A is a mycotoxin responsible for the hepatogenous photosensitisation disease facial eczema in ruminants. Sporidesmin A has a role as a mycotoxin and a Wnt signalling activator .

HY-N7132R

Menthyl acetate (Standard)	Structural Classification Natural Products Acacia farnesiana (Linn.) Willd. Labiatae Source classification Plants	Others
Menthyl acetate (Standard) is the analytical standard of Menthyl acetate. This product is intended for research and analytical applications. ?Menthyl acetate (L-Menthyl acetate) is a derivative of L-menthol. ?Menthyl acetate is effective to enhance 5-aminolevulinic acid (ALA) skin permeation .

HY-B1695

Methyl nicotinate Nicotinic acid methyl ester	Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Inflammation/Immunology Disease Research Fields	Others
Methyl nicotinate (Nicotinic acid methyl ester) is an orally active vasodilator. Methyl nicotinate has analgesic activity. Methyl nicotinate causes local skin erythema when applied topically to the skin. Methyl nicotinate is used as an active ingredient in over-the-counter topical preparations for the study of muscle and joint pain .

HY-N15534

5β,6α-Dihydroxy-3β-(β-glucopyranosyloxy)-7-megastigmen-9-one	Structural Classification Source classification Piperaceae Piper crocatum Ruiz & Pav. Plants Saccharides Monosaccharides	Others
5β,6α-Dihydroxy-3β-(β-glucopyranosyloxy)-7-megastigmen-9-one (Compound 2) is a compound found in Agastache rugosa. 5β,6α-Dihydroxy-3β-(β-glucopyranosyloxy)-7-megastigmen-9-one (Compound 2) is promising for research of skin pigment-related diseases .

HY-118157

3,5,7-Trimethoxyflavone	Structural Classification Flavonoids Flavones Orchidaceae Source classification Plants Nervilia concolor (Blume) Schltr.	MMP
3,5,7-Trimethoxyflavone, a flavonoid compound, can inhibit the TNF-α-induced high expression and secretion of MMP-1 by cells. 3,5,7-Trimethoxyflavone can be used to ameliorate skin damage .

HY-B1695R

Methyl nicotinate (Standard)	Structural Classification Natural Products Microorganisms Source classification	Others
Methyl nicotinate (Standard) is the analytical standard of Methyl nicotinate. This product is intended for research and analytical applications. Methyl nicotinate (Nicotinic acid methyl ester) is an orally active vasodilator. Methyl nicotinate has analgesic activity. Methyl nicotinate causes local skin erythema when applied topically to the skin. Methyl nicotinate is used as an active ingredient in over-the-counter topical preparations for the study of muscle and joint pain .

HY-N2059

Santalol	Structural Classification other families Classification of Application Fields Santalum album Linn. Terpenoids Sesquiterpenes Source classification Plants Disease Research Fields Santalaceae Cancer	Apoptosis
Santalol is a mixture of α and β-isomer santalol. α-Santalol is found in sandalwood oil. α-Santalol is a promising anti-cancer agent against cancers such as oral, breast, prostate and skin cancer. Santalol has sedative activity .

HY-N7113

Squalane	Structural Classification Natural Products Animals Classification of Application Fields Source classification Disease Research Fields Cancer	Others
Squalane, found in certain fish oils (especially shark liver oil), and some vegetable oils, is a saturated derivative of Squalene. Squalane shows anticancer, antioxidant, skin hydrating, and emollient activities .

HY-101078A

(±)-Epibatidine dihydrochloride CMI 545 dihydrochloride	Alkaloids Structural Classification Animals Source classification Pyridine Alkaloids	Dopamine Receptor
(±)-Epibatidine (CMI 545) dihydrochloride is an agonist of nicotinic with potent analgetic activity. (±)-Epibatidine (CMI 545) dihydrochloride is an alkaloid originally characterized from frog skin. (±)-Epibatidine (CMI 545) dihydrochloride have little or no activity at a variety of other central receptors, including opioid receptors, muscarinic receptors, adrenergic receptors, dopamine receptors, serotonin receptors, and gamma-aminobutyric acid receptors .

HY-118834

Teleocidin A1 Lyngbyatoxin A	Alkaloids Microorganisms Classification of Application Fields Source classification Disease Research Fields Indole Alkaloids Cancer	PKC
Teleocidin A1 (Lyngbyatoxin A), a highly toxic skin irritant, is a potent activator of protein kinase C (PKC). Teleocidin A1 shows antiproliferative activity against HeLa cancer cells (IC₅₀=9.2 nM) .

HY-P0244

Dermorphin	Structural Classification Natural Products Animals Source classification Phenols Polyphenols	Opioid Receptor
Dermorphin is a natural heptapeptide μ-opioid receptor (MOR) agonist found in amphibian skin. Inhibition of neuropathic pain .

HY-P0244A

Dermorphin TFA	Structural Classification Animals Source classification Phenols Polyphenols	Opioid Receptor
Dermorphin TFA is a natural heptapeptide μ-opioid receptor (MOR) agonist found in amphibian skin. Inhibition of neuropathic pain .

HY-N3612

Communic acid (+)-Communic acid	Structural Classification Animals Ketones, Aldehydes, Acids Source classification	Bacterial Akt MMP
Communic acid ((+)-Communic acid) is a natural compound isolated from the branches of Platycladus orientalis. Communic acid displays minimum inhibitory concentration of 31 μM and IC₅₀ of 15 μM against M. tuberculosis H37Ra.Communic acid exhibits protective effects against UVB-induced skin aging .

HY-N2551

Vitamin U chloride S-Methylmethionine sulfonium chloride	Plants Compositae	Others
Vitamin U (S-Methylmethionine sulfonium) chloride is an orally active anti-ulcer agent with antioxidant activity. Vitamin U inhibits adipocyte differentiation. Vitamin U promotes skin wound healing.Vitamin U can be used in the research of gastrointestinal ulceration .

HY-101546A

Cavidine (+)-Cavidine	Structural Classification Alkaloids Corydalis yanhusuo W. T. Wang Source classification Plants Isoquinoline Alkaloids Papaveraceae	COX
Cavidine ((+)-Cavidine) is a selective COX-2 inhibitor which possesses anti-inflammatory activity. Cavidine can be used for the research of skin injuries, hepatitis, cholecystitis, and scabies. Cavidine ameliorates LPS (HY-D1056)-induced acute lung injury via NF-κB signaling pathway .

HY-N7113R

Squalane (Standard)	Structural Classification Natural Products Animals Source classification	Others
Squalane (Standard) is the analytical standard of Squalane. This product is intended for research and analytical applications. Squalane, found in certain fish oils (especially shark liver oil), and some vegetable oils, is a saturated derivative of Squalene. Squalane shows anticancer, antioxidant, skin hydrating, and emollient activities .

HY-N7677

Isookanin	Structural Classification Classification of Application Fields Source classification Plants Compositae Infection Flavonoids Deguelia rufescens (Benth.) R.A.Camargo & A.M.G.Azevedo Flavonones Phenols Polyphenols Inflammation/Immunology Disease Research Fields	HSV
Isookanin can be used for the research of various illnesses including cancers, skin rashes, snake and insects bites, diabetes mellitus, diarrhoea. Isookanin acts as an anti-viral agent against HSV and varicella-zoster virus (VZV). Antioxidant activity .

HY-N3127

Orobol	Flavonoids Classification of Application Fields Leguminosae Glycine max (L.) merr Source classification Phenols Polyphenols Metabolic Disease Plants Disease Research Fields Isoflavones	Casein Kinase PI3K VEGFR
Orobol is one of the major soy isoflavones and has various pharmacological activities, including anti-skin-aging and anti-obesity effects. Orobol inhibits CK1ε, VEGFR2, MAP4K5, MNK1, MUSK, TOPK, and TNIK (IC₅₀=1.24-4.45 μM). Orobol also inhibits PI3K isoforms (IC₅₀=3.46-5.27 μM for PI3K α/β/γ/K/δ) .

HY-N0543

Allantoin 2 Publications Verification 5-Ureidohydantoin	Structural Classification Natural Products Microorganisms Classification of Application Fields Anti-aging Source classification Disease markers Nervous System Disorder Endogenous metabolite Inflammation/Immunology Disease Research Fields Cancer	Imidazoline Receptor Endogenous Metabolite
Allantoin is a skin conditioning agent that promotes healthy skin, stimulates new and healthy tissue growth.

HY-N3002

α-Arbutin 4-Hydroxyphenyl α-D-glucopyranoside	Structural Classification Monophenols Classification of Application Fields Source classification Phenols Metabolic Disease Cosmetic Research Ericaceae Plants Disease Research Fields	Tyrosinase
α-Arbutin (4-Hydroxyphenyl α-D-glucopyranoside) is a tyrosinase inhibitor, which is used as an effective skin whiteners. α-Arbutin is promising for research of various diseases such as hyperpigmentation disorders, types of cancers, central nervous system disorders, osteoporosis, diabetes .

HY-N6715

Tenuazonic acid	Infection Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease Research Fields Biological Pesticide Research Agricultural Research	Influenza Virus Bacterial Enterovirus Photosystem II
Tenuazonic acid is a nonhost-selective mycotoxin belonging to the tetramic acids family. Tenuazonic acid inhibits protein biosynthesis on ribosomes by suppressing the release of new protein. Tenuazonic acid is acutely toxic, and oral LD₅₀ is set between 81-186 mg/kg in rats and mice. Tenuazonic acid blocks electron transport beyond the primary quinone receptor (QA) by interacting with the D1 protein and is a *photosystem II (PSII)* inhibitor. In addition, Tenuazonic acid has antiviral effects on measles virus, enterovirus, respiratory virus and so on. Tenuazonic acid has an inhibitory effect on skin cancer .

HY-N0543R

Allantoin (Standard)	Structural Classification Natural Products Microorganisms Source classification Disease markers Nervous System Disorder Endogenous metabolite	Imidazoline Receptor Endogenous Metabolite
Allantoin (Standard) is the analytical standard of Allantoin. This product is intended for research and analytical applications. Allantoin is a skin conditioning agent that promotes healthy skin, stimulates new and healthy tissue growth.

HY-117081

C30(ω-hydroxy) Ceramide (d18:1/30:0)	Structural Classification Natural Products Classification of Application Fields Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
C30(ω-hydroxy) Ceramide (d18:1/30:0), a sphingolipid, is an epidermis-specifically vital component of the water barrier in mammalian skin. C30(ω-hydroxy) Ceramide (d18:1/30:0) is expressed in epidermal keratinocytes and male germ cells during their differentiation and maturation. C30(ω-hydroxy) Ceramide (d18:1/30:0) deficiency in the epiderm of Elovl4 deletion or mutation mice .

HY-N2278

Kushenol A 1 Publications Verification Leachianone E	Structural Classification Flavonoids Classification of Application Fields Leguminosae Flavonones Source classification Phenols Polyphenols Sophora flavescens Aiton Plants Disease Research Fields Cancer	Tyrosinase Glycosidase
Kushenol A (Leachianone E) is isolated from the root of Sophora flavescent. Kushenol A is a non-competitive tyrosinase inhibitor to block the conversion of L-tyrosine to L-DOPA, shows IC₅₀ and K_ivalues of 1.1 μM and 0.4 μM, respectively . Kushenol A is a flavonoid antioxidant, has inhibitory effects on alpha-glucosidase (IC₅₀: 45 μM; K_i: 6.8 μM) and β-amylase . Kushenol A is confirmed as potential inhibitors of enzymes targeted by cosmetics for skin whitening and aging .

HY-N2877

Annonacin	Structural Classification Natural Products Neurological Disease Classification of Application Fields Annona muricata Linn. Source classification Plants Annonaceae Disease Research Fields	Potassium Channel Sodium Channel Na+/K+ ATPase Calcium Channel Apoptosis
Annonacin is an acetylgenin that is toxic by inhibiting the pathway of the mitochondrial complex. Annonacin increases tau phosphorylation in R406W ^+/+ mice. Annonacin acts as an inhibitor of the sodium/potassium and sarcoplasmic reticulum (SERCA) ATPase pumps. Annonacin has significant killing effect on ovarian cancer cell, cervical cancer cell, breast cancer cell, bladder cancer cell and skin cancer cell. Annonacin induces apoptosis through Bax and Caspase-3-related pathways .

HY-W011303

Phytosphingosine 1 Publications Verification 4-Hydroxysphinganine	Infection Structural Classification Natural Products Human Gut Microbiota Metabolites Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Cancer	Apoptosis Endogenous Metabolite Fungal Free Fatty Acid Receptor
Phytosphingosine is a phospholipid with anti-inflammatory, antibacterial, and anti-cancer activities, which can induce apoptosis. Phytosphingosine is an immune regulator and can be used in the study of inflammatory skin diseases. Phytosphingosine is also an activator of GPR120 with an IC₅₀ value of 33.4 μM and can be used in the study of type II diabetes .

HY-Y1129

3-Hydroxypyridine	Alkaloids Structural Classification Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Source classification Other Diseases Pyridine Alkaloids Endogenous metabolite Disease Research Fields	Photosensitizer Apoptosis
3-Hydroxypyridine is a compound that can be isolated from bamboo grass. As an endogenous photosensitizer present in human skin, 3-hydroxypyridine can mediate oxidative stress, proliferation inhibition and apoptosis of skin cells through UVA/UVB excitation .

HY-W015967

Glycolic acid 1 Publications Verification Hydroxyethanoic acid	Structural Classification Immune System Disorder Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Disease markers Endocrine diseases Metabolic Disease Nervous System Disorder Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite Tyrosinase
Glycolic acid is an inhibitor of tyrosinase, suppressing melanin formation and lead to a lightening of skin colour.

HY-113008

Urocanic acid 1 Publications Verification	Structural Classification Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease markers Endocrine diseases Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite
Urocanic acid, produced in the upper layers of mammalian skin, is a major absorber of ultraviolet radiation (UVR).

HY-B0900

Anethole 1 Publications Verification Anise camphor; p-Propenylanisole; Isoestragole	Structural Classification Classification of Application Fields Source classification Plants Microorganisms Simple Phenylpropanols Leguminosae Phenylpropanoids Umbelliferae Vernonia Schreb. Glycyrrhiza uralensis Fisch. Disease Research Fields Cancer	Apoptosis Fungal Bacterial MMP NF-κB
Anethole is a type of orally active aromatic compound that is widely found in nature and used as a flavoring agent. Anethole possesses anticancer, anti-inflammatory, antioxidant, antibacterial, antifungal, anesthetic, estrogenic, central nervous system depressant, hypnotic, insecticidal, and gastroprotective effects. Anethole can be used in the study of oxidative stress-related skin diseases and prostate cancer .

HY-N14650

Hazimycin 6	Structural Classification Natural Products Microorganisms Source classification	Bacterial
Hazimycin 6 has weak activity against Gram-negative bacteria, yeast and skin fungi .

HY-141579

Sphingosine (d17:1)	Animals Source classification	Biochemical Assay Reagents
Sphingosine (d17:1) is a 17-carbon sphingosine found in human skin .

HY-N14644

Hazimycin 5	Structural Classification Natural Products Microorganisms Source classification	Bacterial
Hazimycin 5 has weak activity against Gram-negative bacteria, yeast and skin fungi .

HY-W011303R

Phytosphingosine (Standard) 4-Hydroxysphinganine (Standard)	Structural Classification Natural Products Human Gut Microbiota Metabolites Source classification Endogenous metabolite	Apoptosis Endogenous Metabolite Fungal Free Fatty Acid Receptor
Phytosphingosine (Standard) is the analytical standard of Phytosphingosine. This product is intended for research and analytical applications. Phytosphingosine is a phospholipid with anti-inflammatory, antibacterial, and anti-cancer activities, which can induce apoptosis. Phytosphingosine is an immune regulator and can be used in the study of inflammatory skin diseases. Phytosphingosine is also an activator of GPR120 with an IC50 value of 33.4 μM and can be used in the study of type II diabetes[1][2][3][4].

HY-N11874

Staphyloferrin A	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source classification	Bacterial
Staphyloferrin A is a siderophore protein that can be combined with antibiotics to study drug-resistant bacteria that cause skin diseases .

HY-N5098

Arenobufagin 3-hemisuberate	Cardiovascular Disease Classification of Application Fields Animals Source classification Disease Research Fields Steroids	Others
Arenobufagin 3-hemisuberate is a natural compound as a cardiotonic steroid isolated from the skin of Japanese toad .

HY-N11023

Mahanimbidine	Structural Classification Alkaloids Pyrrole Alkaloids Source classification Rutaceae Murraya koenigii (L.) Spreng Plants	Others
Mahanimbidine is a terpenoid alkaloid. Mahanimbidine can be isolated from the leaves and stem skins of the Murraya koenigii Spreng .

HY-P0253

Xenopsin	Structural Classification Natural Products Animals Classification of Application Fields Source classification Metabolic Disease Disease Research Fields	Neurotensin Receptor
Xenopsin, a neurotensin-like octapeptide from Xenopus laevis skin . Xenopsin is an inhibitor of Tetragastrin stimulated gastric acid secretion .

HY-B1183

Hydrocortisone acetate 1 Publications Verification Hydrocortisone 21-acetate; Cortisol 21-acetate	Structural Classification Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Endocrinology Steroids	Glucocorticoid Receptor Endogenous Metabolite
Hydrocortisone acetate (Hydrocortisone 21-acetate) is a corticosteroid used to reduce swelling, itching and pain caused by minor skin irritations or hemorrhoids .

HY-119358

Traumatic Acid 2 Publications Verification	Structural Classification Classification of Application Fields Source classification Plants Phaseolus vulgaris Linn. Cytokinin Agricultural Research Microorganisms Leguminosae Ketones, Aldehydes, Acids Phytohormone Inflammation/Immunology Disease Research Fields	Reactive Oxygen Species (ROS) Apoptosis
Traumatic Acid is a wound healing agent and a cytokinin (phytohormone). Traumatic Acid enhances the biosynthesis of collagen in cultured human skin fibroblasts. Traumatic Acid inhibits MCF-7 breast cancer cells viability and enhances apoptosis and oxidative stress. Traumatic Acid can be used in studies of cancer, circulatory disorders (including arterial hypertension), and skin diseases associated with oxidative stress and impaired collagen biosynthesis .

Cat. No.	Product Name	Chemical Structure

HY-N0543S

Allantoin-13C2,15N4
Allantoin- ¹³C₂, ¹⁵N₄ is the ¹³C and ¹⁵N labeled Allantoin . Allantoin is a skin conditioning agent that promotes healthy skin, stimulates new and healthy tissue growth .

HY-W015967S

Glycolic acid-d2
Glycolic acid-d₂ is the deuterium labeled Glycolic acid. Glycolic acid is an inhibitor of tyrosinase, suppressing melanin formation and lead to a lightening of skin colour.

HY-130187S

Sapienic acid-d19

Sapienic acid-d19 is a deuterated labeled Sapienic acid . Sapienic acid is a fatty acid commonly found on the skin and in mucosa. Sapienic acid has variable antimicrobial activities against Gram-positive and Gram-negative bacteria found on the skin and in the oral cavity. Sapienic acid is active against Streptococcus sanguinis, Streptococcus mitis and Fusobacterium nucleatum with MBC values of 31.3 μg/mL, 375.0 μg/mL and 93.8 μg/mL, respectively .

HY-B0928S

Homosalate-d4
Homosalate-d₄ is the deuterium labeled Homosalate. Homosalate is an organic compound used in some sunscreens, it is used as a chemical UV filter, protecting the skin from sun damage.

HY-W009326S

Laurocapram-15N
Laurocapram-15N is a deuterated labeled Laurocapram . Laurocapram is a chemical penetration enhancer that increases the permeability of compounds through the skin and mucous membranes, thereby improving their local or systemic efficacy. Laurocapram improves the skin permeability of a variety of hydrophilic and lipophilic compounds .

HY-B0220S3

Erythromycin-13C2
Erythromycin- ¹³C₂ is a macrolide antibiotic that can be used to treat respiratory infections, skin infections, and chlamydia infections .

HY-Y1129S

3-Hydroxypyridine-d4
3-Hydroxypyridine-d₄ is the deuterium labeled 3-Hydroxypyridine (HY-Y1129). 3-Hydroxypyridine is a compound that can be isolated from bamboo grass. As an endogenous photosensitizer present in human skin, 3-hydroxypyridine can mediate oxidative stress, proliferation inhibition and apoptosis of skin cells through UVA/UVB excitation .

HY-B0485S

Fluocinonide-d6
Fluocinonide-d₆ is deuterated labeled Fluocinonide (HY-B0485). Fluocinonide (Vanos) is a glucocorticoid steroid with anti-inflammatory activity that acts on skin diseases.

HY-113008S1

Urocanic acid-13C3
Urocanic acid- ¹³C₃ is the ¹³C labeled Urocanic acid . Urocanic acid, produced in the upper layers of mammalian skin, is a major absorber of ultraviolet radiation (UVR) .

HY-30270S

Mequinol-d4
Mequinol-d₄ is the deuterium labeled Mequinol[1]. Mequinol (4-Methoxyphenol) is one of bioactive components in Mercurialis. Mequinol is used for skin depigmentation[2].

HY-B0704S

Azelaic acid-d14
Azelaic acid-d₁₄ is the deuterium labeled Azelaic acid . Azelaic acid is an organic compound produced by the ozonolysis of oleic acid;component of a number of hair and skin conditioners .

HY-W740028

Cefditoren-d3 sodium

Cefditoren-d₃ (sodium) (ME 1206-d₃) is deuterium labeled Cefditoren (sodium). Cefditoren sodium (ME 1206) is a broad-spectrum, third-generation, oral cephalosporin antibacterial with enhanced stability against many common β lactamases. Cefditoren sodium has activity against Gram-negative organisms and Gram-positive organisms. Cefditoren sodium can be used in the research of infection diseases such as acute exacerbations of chronic bronchitis, community-acquired pneumonia (CAP), streptococcal pharyngitis/tonsillitis, or uncomplicated skin and skin structure infections .

HY-W778203

Glycolic acid-13C2
Glycolic acid- ¹³C₂ is the ¹³C-labeled Glycolic acid (HY-W015967). Glycolic acid- ¹³C₂ is an inhibitor of tyrosinase, suppressing melanin formation and lead to a lightening of skin colour.

HY-14957AS

Ozenoxacin-d3 hydrochloride
Ozenoxacin-d₃ (hydrochloride) is the deuterium labeled Ozenoxacin hydrochloride. Ozenoxacin hydrochloride is a nonfluorinated quinolone antibacterial, which shows potent activities against the main microorganisms isolated from skin and soft tissue infections .

HY-17452AS

Cefditoren Pivoxil-d3

Cefditoren Pivoxil-d₃ (Cefditoren pivoxyl-d₃) is deuterium labeled Cefditoren Pivoxil. Cefditoren Pivoxil (ME 1207) is a broad-spectrum, third-generation, oral cephalosporin antibacterial with enhanced stability against many common β lactamases. Cefditoren Pivoxil has activity against Gram-negative organisms and Gram-positive organisms. Cefditoren Pivoxil can be used in the research of infection diseases such as acute exacerbations of chronic bronchitis, community-acquired pneumonia (CAP), streptococcal pharyngitis/tonsillitis, or uncomplicated skin and skin structure infections .

HY-14957S

Ozenoxacin-d3
Ozenoxacin-d₃ is the deuterium-labeled Ozenoxacin (HY-14957). Ozenoxacin-d₃ is a nonfluorinated quinolone antibacterial, which shows potent activities against the main microorganisms isolated from skin and soft tissue infections.

HY-13600S1

Clobetasol propionate-d5
Clobetasol propionate-d₅ is a deuterium substitute of Clobetasol propionate. Clobetasol propionate is a potent, selective CYP3A5 inhibitor with a IC₅₀ of 0.206 μM and has potential for use in the study of psoriasis and other skin diseases .

HY-W020044S1

DL-alpha-Tocopherol-d9
DL-alpha-Tocopherol-d₉ is the deuterium labeled DL-alpha-Tocopherol . DL-alpha-Tocopherol is a synthetic vitamin E, with antioxidation effect. DL-alpha-Tocopherol protects human skin fibroblasts against the cytotoxic effect of UVB .

HY-B0935S

Benzyl benzoate-d5
Benzyl benzoate-d₅ is the deuterium labeled Benzyl benzoate . Benzyl benzoate (Benzoic acid benzyl ester) is a fragrance ingredient in cosmetic products. Benzyl benzoate can be used for the research of Scabies and Demodex-associated inflammatory skin conditions .

HY-109044S

Tapinarof-d5
Tapinarof-d₅ (WBI-1001-d₅) is deuterium labeled Tapinarof. Tapinarof (WBI-1001) is a natural aryl hydrocarbon receptor (AhR) agonist with an EC₅₀ of 13 nM. Tapinarof resolves skin inflammation in mice .

HY-N7113S

Squalane-d62
Squalane-d₆₂ is the deuterium labeled Squalane . Squalane, found in certain fish oils (especially shark liver oil), and some vegetable oils, is a saturated derivative of Squalene. Squalane shows anticancer, antioxidant, skin hydrating, and emollient activities .

HY-B0935S1

Benzyl benzoate-d12
Benzyl benzoate-d₁₂ is the deuterium labeled Benzyl benzoate . Benzyl benzoate (Benzoic acid benzyl ester) is a fragrance ingredient in cosmetic products. Benzyl benzoate can be used for the research of Scabies and Demodex-associated inflammatory skin conditions .

HY-125407S

Palmitoyl serinol-d5
Palmitoyl serinol-d₅ is the deuterium labeled Palmitoyl serinol . Palmitoyl serinol (N-Palmitoyl serinol) is an analog of the endocannabinoid N-palmitoyl ethanolamine (PEA). Palmitoyl serinol improves the epidermal permeability barrier in both normal and inflamed skin .

HY-W020044S

DL-alpha-Tocopherol-13C3
DL-alpha-Tocopherol- ¹³C₃ is the ¹³C-labeled DL-alpha-Tocopherol. DL-alpha-Tocopherol is a synthetic vitamin E, with antioxidation effect. DL-alpha-Tocopherol protects human skin fibroblasts against the cytotoxic effect of UVB .

HY-B0316S1

Avobenzone-d3
Avobenzone-d₃ is deuterium labeled Avobenzone. Avobenzone, a dibenzoylmethane compound, is one of the most widely used filters in sunscreens for skin photoprotection in the UVA band. Avobenzone is an endocrine disruptor that directly binds to estrogen receptor β and acts as an estrogen agonist .

HY-76025S

1,4-Dibromobenzene-d4
1,4-Dibromobenzene-d₄ is a deuterium labeled 1,4-Dibromobenzene. 1,4-Dibromobenzene is used as a fumigant and as a chemical intermediate for pharmaceuticals. Inhalation exposure gives rise to dizziness and chokingwhereas contact with skin or eye produces inflammation and burning in humans .

HY-B0316S

Avobenzone-13C,d3
Avobenzone- ¹³C,d₃ is the ¹³C- and deuterium labeled Avobenzone. Avobenzone, a dibenzoylmethane compound, is one of the most widely used filters in sunscreens for skin photoprotection in the UVA band. Avobenzone is an endocrine disruptor that directly binds to estrogen receptor β and acts as an estrogen agonist .

HY-N2086S

Ethyl palmitate-d31
Ethyl palmitate-d₃₁ is the deuterium labeled Ethyl palmitate. Ethyl palmitate, a fatty acid ethyl ester (FAEE), shows a marked preference for the synthesis of ethyl palmitate and ethyl oleate over other FAEEs in human subjects after ethanol consumption. Ethyl palmitate is used as a hair- and skin-conditioning agent .

HY-30151S

Methoxsalen-d3
Methoxsalen-d₃ is the deuterium labeled Methoxsalen[1]. Methoxsalen (8-Methoxypsoralen) is a potent tricyclic furocoumarin suicide inhibitor of CYP (cytochrome P-450), is an agent used to treat psoriasis, eczema, vitiligo and some cutaneous Lymphomas in conjunction with exposing the skin to sunlight[2].

HY-B0458AS

Cefprozil-d4
Cefprozil-d₄ is the deuterium labeled Cefprozi (HY-B0458A) . Cefprozil is a second-generation cephalosporin type antibiotic. Cefprozil exhibits broad-spectrum antibacterial activity, and is orally active. Cefprozil can be used for the study of pharyngitis, tonsillitis, otitis media, and uncomplicated skin infections .

HY-14283S1

Luliconazole-d3
Luliconazole-d₃ (NND 502-d₃) is deuterium labeled Luliconazole. Luliconazole (NND 502)?is a topical antifungal imidazole antibiotic with broad-spectrum and potent antifungal activity. Luliconazole can be used for the research of skin infection, including?dermatophytosis, tinea corporis, tinea pedis?et al .

HY-14283S

Luliconazole-13C7
Luliconazole- ¹³C₇ (NND 502- ¹³C₇) is ¹³C labeled Luliconazole. Luliconazole (NND 502)?is a topical antifungal imidazole antibiotic with broad-spectrum and potent antifungal activity. Luliconazole can be used for the research of skin infection, including?dermatophytosis, tinea corporis, tinea pedis?et al .

HY-108411S

Emedastine-13C,d3 fumarate
Emedastine- ¹³C,d₃ fumarate is the ¹³C- and deuterium labeled Emedastine. Emedastine is an orally active, selective and high affinity histamine H1 receptor antagonist with a K_i value of 1.3 nM. Emedastine is a benzimidazole derivative with potent antiallergic properties and used for allergic rhinitis, allergic skin diseases and allergic conjunctivitis .

HY-B1805S

Triclocarban-d4

Triclocarban-d₄ is the deuterium labeled Triclocarban. Triclocarban (3,4,4′-Trichlorocarbanilide), a broad spectrum antibacterial compound, is widely used in a broad range of applications such as the production of soaps, skin creams, toothpastes and deodorants. Triclocarban is a potential endocrine-disrupting chemical with the capacity to modulate androgen and estrogen activities as well as other hormone-mediated biological processes .

HY-B0688S

Dapsone-d8
Dapsone-d₈ is a deuterium labeled Dapsone. Dapsone is an orally active and blood-brain penetrant sulfonamide antibiotic with antibacterial, antigenic and anti-inflammatory activities . Dapsone?exerts effective antileprosy activity?and inhibits folate synthesis in cell extracts of?M. leprae. Dapsone can be used as an anticonvulsant and also in the research of skin and glioblastoma diseases .

HY-W014612S

Eugenol acetate-d3
Eugenol acetate-d₃ is the deuterated labeled Eugenol acetate (HY-W014612). Eugenol acetate (Eugenyl acetate) is an antibacterial, anticancer, anti-inflammatory and antioxidant. Eugenol acetate inhibits NF-κB and enhances the expression of p53 and p21 (WAF1). Eugenol acetate can prevent chemically induced skin cancer, inhibit cancer cell proliferation and induce apoptosis .

HY-A0067S

Oxybenzone-d5
Oxybenzone-d₅ is the deuterium labeled Oxybenzone . Oxybenzone (Benzophenone 3) is a commonly used UV filter in sun tans and skin protectants. Oxybenzone act as endocrine disrupting chemicals (EDCs) and can pass through the placental and blood-brain barriers. Benzophenone-3 impairs autophagy, alters epigenetic status, and disrupts retinoid X receptor signaling in apoptotic neuronal cells .

HY-W707384

Candesartan Cilexetil-d11
Candesartan Cilexetil-d₁₁ (TCV-116-d₁₁) is deuterium labeled Candesartan Cilexetil. Candesartan Cilexetil (TCV-116) is an angiotensin II receptor inhibitor. Candesartan Cilexetil ameliorates the pulmonary fibrosis and has antiviral and skin wound healing effect. Candesartan Cilexetil can be used for the research of high blood pressure .

HY-W585956

Triclocarban-13C6

Triclocarban- ¹³C₆ is the ¹³C labeled isotope of Triclocarban (HY-B1805). Triclocarban (3,4,4′-Trichlorocarbanilide), a broad spectrum antibacterial compound, is widely used in a broad range of applications such as the production of soaps, skin creams, toothpastes and deodorants. Triclocarban is a potential endocrine-disrupting chemical with the capacity to modulate androgen and estrogen activities as well as other hormone-mediated biological processes .

HY-141582S

Ceramide 3-d3

Ceramide 3-d₃ (N-Stearoyl phytosphingosine-d₃) is deuterium labeled Ceramide 3. C18 Phytoceramide (t18:0/18:0) (Cer(t18:0/18:0)) is a bioactive sphingolipid found in the stratum corneum of Saccharomyces cerevisiae, wheat grain, and mammalian epidermis. Cer(t18:0/18:0) consists of a phytosphingosine backbone amine linked to a C18 fatty acid chain. Cer(t18:0/18:0) has the function of regulating apoptosis, cell differentiation, proliferation of smooth muscle cells and inhibition of mitochondrial respiratory chain. It also suppresses the expression of allergic cytokines IL-4, TNF-α, and transcription factors c-Jun and NF-κB in histone-stimulated mouse skin tissue. Formulations containing cer(t18:0/18:0) have been used as skin protectants in cosmetics as they reduce water loss and prevent epidermal dehydration and irritation .

HY-B0226S

Nitrofurazone-13C,15N2

Nitrofurazone- ¹³C, ¹⁵N₂ (Nitrofural- ¹³C, ¹⁵N₂) is the ¹³C and ¹⁵N labled Nitrofurazone (HY-B0226) . Nitrofurazone is a potential antibiotic that can be used topically to treat wounds, burns, ulcers and skin infections to combat various microorganisms and to prepare surfactants . Nitrofurazone may affect the ecosystem function in Marine environment and affect the functional processes of epiphytic fauna .

HY-W011303S

Phytosphingosine-d7

Phytosphingosine-d₇ (4-Hydroxysphinganine-d₇) is deuterium labeled Phytosphingosine. Phytosphingosine is a phospholipid with anti-inflammatory, antibacterial, and anti-cancer activities, which can induce apoptosis. Phytosphingosine is an immune regulator and can be used in the study of inflammatory skin diseases. Phytosphingosine is also an activator of GPR120 with an IC₅₀ value of 33.4 μM and can be used in the study of type II diabetes .

HY-A0294S

Ertapenem-d4
Ertapenem-d₄ (MK-0826-d₄) is deuterium labeled Ertapenem. Ertapenem (MK-0826) is a broad spectrum and long acting β-lactam antibiotic. Ertapenem has a broad-spectrum anti-anaerobic activity against a variety of anaerobes with a mode MIC of 0.12 μg/mL. Ertapenem can be used for the research of severe infections caused by bacteria in the skin, lungs, stomach, pelvis, and urinary tract .

HY-B0136S

Cefdinir-13C,15N2

Cefdinir- ¹³C, ¹⁵N₂ (FK-482- ¹³C, ¹⁵N₂) is ¹³C and ¹⁵N labeled Cefdinir. Cefdinir (FK-482) is a semi-synthetic, broad-spectrum antibiotic in the third generation of the cephalosporin class, which is proved to be effective for infections caused by several Gram-negative and Gram-positive bacteria. Cefdinir can be used for the research of common bacterial infections of the ear, sinus, throat, and skin .

HY-A0067S1

Oxybenzone-13C6

Oxybenzone- ¹³C₆ (Benzophenone 3- ¹³C₆) is the ¹³C-labeled Oxybenzone (HY-A0067). Oxybenzone (Benzophenone 3) is a commonly used UV filter in sun tans and skin protectants. Oxybenzone act as endocrine disrupting chemicals (EDCs) and can pass through the placental and blood-brain barriers. Benzophenone-3 impairs autophagy, alters epigenetic status, and disrupts retinoid X receptor signaling in apoptotic neuronal cells .

HY-W653958

Oxybenzone-d3

Oxybenzone-d₃ (Benzophenone 3-d₃) is a deuterium labeled Oxybenzone (HY-A0067). Oxybenzone (Benzophenone 3) is a commonly used UV filter in sun tans and skin protectants. Oxybenzone act as endocrine disrupting chemicals (EDCs) and can pass through the placental and blood-brain barriers. Benzophenone-3 impairs autophagy, alters epigenetic status, and disrupts retinoid X receptor signaling in apoptotic neuronal cells .

HY-B1805S1

Triclocarban-13C13

Triclocarban- ¹³C₁₃ (3,4,4'-Trichlorocarbanilide- ¹³C₁₃) is ¹³C labeled Triclocarban. Triclocarban (3,4,4′-Trichlorocarbanilide), a broad spectrum antibacterial compound, is widely used in a broad range of applications such as the production of soaps, skin creams, toothpastes and deodorants. Triclocarban is a potential endocrine-disrupting chemical with the capacity to modulate androgen and estrogen activities as well as other hormone-mediated biological processes .

HY-W004305S

Hexadecanal-d5

Hexadecanal-d₅ (Palmitaldehyde-d₅) is deuterium labeled Hexadecanal. Hexadecanal (Palmitaldehyde) , a volatile long-chain aliphatic aldehyde, is emitted from human feces, skin, and breath. The receptor for hexadecanal(OR37B) is highly conserved across mammals. Hexadecanal may exert its effects by modulating functional connectivity between the brain substrates of social appraisal and the brain substrates of aggressive execution. Also, Hexadecanal is confirmed to be highly deterrent to the ant Lasius niger. Hexadecanal is promising for the research of startle responses and aggression

HY-B1057S2

Nefopam-d3
Nefopam-d₃ is a deuterium labeled Nefopam (Fenazoxine). Nefopam is a centrally-acting but non-opioid analgesic drug, and Nefopam targets β-catenin protein level in mesenchymal cells .

HY-W653921

Tenuazonic acid-d13

Tenuazonic acid-d₁₃ is deuterium labeled Tenuazonic acid. Tenuazonic acid is a nonhost-selective mycotoxin belonging to the tetramic acids family. Tenuazonic acid inhibits protein biosynthesis on ribosomes by suppressing the release of new protein. Tenuazonic acid is acutely toxic, and oral LD₅₀ is set between 81-186 mg/kg in rats and mice. Tenuazonic acid blocks electron transport beyond the primary quinone receptor (QA) by interacting with the D1 protein and is a photosystem II (PSII) inhibitor. In addition, Tenuazonic acid has antiviral effects on measles virus, enterovirus, respiratory virus and so on. Tenuazonic acid has an inhibitory effect on skin cancer .

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks