2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. TRP Channel
  4. AMG 7905 TFA

AMG 7905 TFA is a hypothermia-inducing transient receptor potential vanilloid type 1 (TRPV1) antagonist. AMG 7905 TFA potentiates TRPV1 channels activation by protons and drives the reflectory inhibition of thermogenesis and tail-skin vasoconstriction, while potently blocking channel activation by capsaicin.

For research use only. We do not sell to patients.

AMG 7905 TFA Chemical Structure

AMG 7905 TFA Chemical Structure

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Other Forms of AMG 7905 TFA:

AMG 7905 TFA Related Antibodies

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Description

AMG 7905 TFA is a hypothermia-inducing transient receptor potential vanilloid type 1 (TRPV1) antagonist. AMG 7905 TFA potentiates TRPV1 channels activation by protons and drives the reflectory inhibition of thermogenesis and tail-skin vasoconstriction, while potently blocking channel activation by capsaicin[1][2].

Molecular Weight

597.58

Formula

C27H25F6N5O2S
SMILES

OC(C(F)(F)F)=O.FC(F)(C1=CC(NCC2CCCCC2)=C(C3=CC(NC4=CC5=C(N=CS5)C=C4)=NC=N3)C=C1)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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AMG 7905 TFA Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AMG 7905AMG7905AMG-7905TRP ChannelTransient receptor potential channelshypothermia-inducingTRPV1protonsreflectory inhibition of thermogenesistail-skin vasoconstrictionInhibitorinhibitorinhibit

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