2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. TRP Channel
  4. AMG 7905 TFA

AMG 7905 TFA is a hypothermia-inducing transient receptor potential vanilloid type 1 (TRPV1) antagonist. AMG 7905 TFA potentiates TRPV1 channels activation by protons and drives the reflectory inhibition of thermogenesis and tail-skin vasoconstriction, while potently blocking channel activation by capsaicin.

For research use only. We do not sell to patients.

AMG 7905 TFA

AMG 7905 TFA Chemical Structure

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Based on 1 publication(s) in Google Scholar

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AMG 7905 TFA Related Antibodies

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Description

AMG 7905 TFA is a hypothermia-inducing transient receptor potential vanilloid type 1 (TRPV1) antagonist. AMG 7905 TFA potentiates TRPV1 channels activation by protons and drives the reflectory inhibition of thermogenesis and tail-skin vasoconstriction, while potently blocking channel activation by capsaicin[1][2].

Molecular Weight

597.58

Formula

C27H25F6N5O2S
Appearance

Solid

Color

Light yellow to yellow

SMILES

OC(C(F)(F)F)=O.FC(F)(C1=CC(NCC2CCCCC2)=C(C3=CC(NC4=CC5=C(N=CS5)C=C4)=NC=N3)C=C1)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (167.34 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6734 mL 8.3671 mL 16.7342 mL
5 mM 0.3347 mL 1.6734 mL 3.3468 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

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Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.6734 mL 8.3671 mL 16.7342 mL 41.8354 mL
5 mM 0.3347 mL 1.6734 mL 3.3468 mL 8.3671 mL
10 mM 0.1673 mL 0.8367 mL 1.6734 mL 4.1835 mL
15 mM 0.1116 mL 0.5578 mL 1.1156 mL 2.7890 mL
20 mM 0.0837 mL 0.4184 mL 0.8367 mL 2.0918 mL
25 mM 0.0669 mL 0.3347 mL 0.6694 mL 1.6734 mL
30 mM 0.0558 mL 0.2789 mL 0.5578 mL 1.3945 mL
40 mM 0.0418 mL 0.2092 mL 0.4184 mL 1.0459 mL
50 mM 0.0335 mL 0.1673 mL 0.3347 mL 0.8367 mL
60 mM 0.0279 mL 0.1395 mL 0.2789 mL 0.6973 mL
80 mM 0.0209 mL 0.1046 mL 0.2092 mL 0.5229 mL
100 mM 0.0167 mL 0.0837 mL 0.1673 mL 0.4184 mL
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AMG 7905 TFA Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AMG 7905AMG7905AMG-7905TRP ChannelTransient receptor potential channelshypothermia-inducingTRPV1protonsreflectory inhibition of thermogenesistail-skin vasoconstrictionInhibitorinhibitorinhibit

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