Pro-xylane  (Synonyms: Hydroxypropyl tetrahydropyrantriol)

Pro-xylane (Hydroxypropyl tetrahydropyrantriol) is a bioactive C-glycoside that targets the biosynthesis pathway of glycosaminoglycans/mucopolysaccharides (GAGs) in the skin matrix and can be absorbed transdermally. Pro-xylane stimulates the biosynthesis of GAGs in fibroblasts, enhances the structural stability of the skin extracellular matrix, improves skin elasticity and moisturizing ability, and delays wrinkle formation. Pro-xylane can effectively promote the synthesis of collagen fibers and hyaluronic acid in the dermis. Pro-xylane is used in the field of anti-aging cosmetics to improve skin hydration and elasticity. Pro-xylane is eco-friendly and biodegradable^[1][2][3][4].

Pro-xylane (0.3-3.0 mM; 96 h) stimulates the synthesis of GAGs in human fibroblasts^[1].
Pro-xylane is the catalytic substrate of the recombinant carbonyl reductase R129E/D210F, whose key activity lies in the high stereoselectivity of the β-S configuration. Under the catalysis of R129E/D210F, Pro-xylane produces >99% β,S-diastereomeric excess^[2].
Pro-xylane has the ability of efficient asymmetric synthesis^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Liposome gel loaded with Pro-xylane intermediate has a promoting effect on the recovery of chronic wounds. In a rat chronic wound model, Pro-xylane intermediate was encapsulated with liposomes to obtain PXYI liposome gel (PXYI-LG). PXYI-LG can promote the healing of chronic wounds in rats and shorten the healing time^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

192.21

C₈H₁₆O₅

439685-79-7

Solid

CC(O)C[C@H]1[C@@H]([C@H]([C@H](O)CO1)O)O

Room temperature in continental US; may vary elsewhere.

• [1]. Cavezza A, et al. Synthesis of Pro-Xylane: a new biologically active C-glycoside in aqueous media. Bioorg Med Chem Lett. 2009 Feb 1;19(3):845-9.  [Content Brief]

  [2]. Dou Z, et al. Extensive gene mining and facile engineering of a novel carbonyl reductase for asymmetric synthesis of anti-aging (S)-Pro-Xylane from d-xylose. Int J Biol Macromol. 2025 May;305(Pt 2):140976.  [Content Brief]

  [3]. Zhao Y, et al. Engineering a Carbonyl Reductase for High-Efficiency Synthesis of Optically Pure (S)-Pro-Xylane: An Alternative Synthetic Route. J Agric Food Chem. 2025 Apr 23;73(16):9759-9768.  [Content Brief]

  [4]. Wu B, et al. Liposomal gel loaded with pro-xylane intermediate promotes chronic wound healing. Pak J Pharm Sci. 2024 Jul;37(4):723-730.  [Content Brief]