2. Immunology/Inflammation
  3. Interleukin Related
  4. Lokivetmab

Lokivetmab  (Synonyms: Anti-Canine IL31 Recombinant Antibody; CAN34D3-65; PF-06443537)

Cat. No.: HY-P99301 Purity: ≥99.0%
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Lokivetmab (Anti-Canine IL31 Recombinant Antibody) is an anti-canine IL-31 monoclonal antibody. Lokivetmab inhibits IL-31-mediated activation of pruritogenic signals in peripheral sensory neurons and reduces TH2-weighted inflammation. Lokivetmab demonstrates long-term efficacy in controlling pruritus and improving skin lesions in dogs with canine atopic dermatitis (CAD). Lokivetmab can be used for the research of atopic dermatitis (AD) in dogs.

For research use only. We do not sell to patients.

CAS No. : 1533403-95-0

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Based on 1 publication(s) in Google Scholar

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Description

Lokivetmab (Anti-Canine IL31 Recombinant Antibody) is an anti-canine IL-31 monoclonal antibody. Lokivetmab inhibits IL-31-mediated activation of pruritogenic signals in peripheral sensory neurons and reduces TH2-weighted inflammation. Lokivetmab demonstrates long-term efficacy in controlling pruritus and improving skin lesions in dogs with canine atopic dermatitis (CAD). Lokivetmab can be used for the research of atopic dermatitis (AD) in dogs[1].

Isotype

Caninized IgG2 kappa
Species Reactivity

Caninized
IC50 & Target[1]

IL-31

 

In Vivo

Lokivetmab (2 mg/kg, i.v. injection, every 4-8 weeks, 12 months) shows long-term efficacy in controlling pruritus and improving skin lesions in dogs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Canine atopic dermatitis (CAD) dog model[1]
Dosage: 2 mg/kg
Administration: i.v. injection, every 4-8 weeks, 12 months
Result: Achieved pruritus control with 87% (64/75) of dogs maintaining PVAS below baseline.
Improved skin lesions with mean VetVAS (skin lesion score).
Gene ID

256353430  [NCBI]

Accession

BAH97742
Application

ELISA, FACS, Functional assay
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Molecular Weight

147.51 kDa

CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Lokivetmab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • IgG2-kappa
Biological Activity
  • Immobilized IL-31 Protein, Canine (HEK293, His, HY-P703718) can bind Lokivetmab. The EC50 for this effect is 59.37 ng/mL.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lokivetmab1533403-95-0Anti-Canine IL31 Recombinant Antibody CAN34D3-65 PF-06443537PF06443537PF 06443537PF-06443537Interleukin RelatedILatopic dermatitiscanineIL-31Inhibitorinhibitorinhibit

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