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Cell-Surface

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ALCAM/CD166 (1) Acyltransferase (2) ADC Antibody (3) Akt (2) AMPK (1) Angiotensin Receptor (2) Antibiotic (1) Antibody-Drug Conjugates (ADCs) (3) Apoptosis (7) Arenavirus (2) Autophagy (3) Bacterial (10) Biochemical Assay Reagents (14) c-Fms (1) c-Kit (9) c-Met/HGFR (3) Calcium Channel (1) Carbonic Anhydrase (1) Caspase (1) CCR (1) CD22 (1) CD28 (1) CD3 (5) CD47 (1) CFTR (10) Complement System (1) Endogenous Metabolite (8) ERK (1) FAK (1) Ferroportin (1) FGFR (1) Fluorescent Dye (10) Furin (2) Galectin (1) Glucosylceramide Synthase (GCS) (2) Glycoprotein VI (2) HIV (4) HPV (2) HSP (2) iGluR (2) Integrin (6) Interleukin Related (3) IRE1 (1) Isotope-Labeled Compounds (1) JNK (1) LAG-3 (1) Lipase (1) Liposome (36) LYTACs (2) mAChR (1) MDM-2/p53 (1) Melanocortin Receptor (1) Melatonin Receptor (1) Mesothelin (2) MHC (1) Microtubule/Tubulin (1) Mitochondrial Metabolism (3) Mitosis (1) MMP (2) mRNA (11) mTOR (1) nAChR (1) Neurotensin Receptor (2) NF-κB (2) OGT (2) p38 MAPK (2) PACAP Receptor (1) Pantetheinase (2) Parasite (1) PD-1/PD-L1 (3) PDGFR (1) PERK (1) PI3K (2) Prion Protein (1) Prokineticin Receptor (1) PROTACs (3) PSMA (1) RSV (1) SARS-CoV (1) Serotonin Transporter (1) STING (1) TGF-β Receptor (3) TNF Receptor (4) Toll-like Receptor (TLR) (1) Topoisomerase (1) Transmembrane Glycoprotein (4) TROP2 (4) Wnt (1)
By Research Areas:	Cancer (89) Cardiovascular Disease (3) Endocrinology (2) Infection (17) Inflammation/Immunology (39) Metabolic Disease (11) Neurological Disease (12)
Click Chemistry:	Labeling and Fluorescence Imaging (1) DBCO (1) Azide (2) Tetrazine (1) Alkynes (1)
Oligonucleotides:	Pegylated Lipids (34) mRNA (11) Polymers (1)

196

Inhibitors & Agonists

Screening Libraries

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Biochemical Assay Reagents

Peptides

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188

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Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oligonucleotides

Targets Recommended: Programmed Cell Death 4 (PDCD4) Itk TOPK NAMPT ALCAM/CD166 GDNF Receptor VISTA BCL6 Tim3 BMI1

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-111496

Sulfo-NHS-SS-Biotin sodium 4 Publications Verification	Fluorescent Dye	Others
Sulfo-NHS-SS-biotin sodium is a long-chain cleavable and cell-impermeant amine-reactive biotinylation reagent. Sulfo-NHS-SS-biotin sodium can be used for the labeling and purifying of cell-surface protein .

HY-P0251

Neurotensin(8-13) 1 Publications Verification	Neurotensin Receptor	Neurological Disease
Neurotensin (8-13) is an active fragment of Neurotensin. Neurotensin(8-13) results in a decrease in cell-surface NT1 receptors (NTR1) density.

HY-P99454

Azintuxizumab vedotin ABBV-838	Antibody-Drug Conjugates (ADCs)	Cancer
Azintuxizumab vedotin (ABBV-838) is an antibody–drug conjugate (ADC) targeting a unique epitope of CD2 subset 1, a cell-surface glycoprotein expressed on multiple myeloma cells .

HY-130588A

Glutathione arsenoxide TFA GSAO TFA	Mitochondrial Metabolism	Cancer
Glutathione arsenoxide (GSAO) TFA is a potential anticancer agent and a tumour metabolism inhibitor. Glutathione arsenoxide TFA targets Mitochondrial endomycin nucleotide transferase (ANT). Glutathione arsenoxide TFA causes cell proliferation arrest and cell death. Glutathione arsenoxide TFA can be used to identify cell-surface proteins, such as Protein disulphide isomerase .

HY-P99230

Pinatuzumab	Integrin CD22	Cancer
Pinatuzumab is a humanized monoclonal antibody targeting cell-surface antigen CD22. Pinatuzumab can be used to synthesize antibody-drug conjugate (ADC) such as Pinatuzumab vedotin (HY-141602). Pinatuzumab can be studied in research on cancer such as non-Hodgkin lymphoma. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001) .

HY-W014605

Diphenylcyclopropenone Diphencyprone	Interleukin Related Apoptosis p38 MAPK IRE1	Inflammation/Immunology Cancer
Diphenylcyclopropenone (Diphencyprone) is a potent hapten acting as a topical immunomodulatory agent, which induces an allergic contact dermatitis. Diphenylcyclopropenone induces an increase of cell-surface thiols in cells of a human monocytic cell line, THP-1. Diphenylcyclopropenone acts on the autoreactive T-lymphocytes within the follicular milieu to induce Apoptosis. Diphenylcyclopropenone can be used for alopecia areata research .

HY-P0251A

Neurotensin(8-13) TFA	Neurotensin Receptor	Neurological Disease
Neurotensin (8-13) is an active fragment of Neurotensin. Neurotensin(8-13) TFA results in a decrease in cell-surface NT1 receptors (NTR1) density.

HY-130588

Glutathione arsenoxide GSAO	Mitochondrial Metabolism	Cancer
Glutathione arsenoxide (GSAO) is a potential anticancer agent and a tumour metabolism inhibitor. Glutathione arsenoxide targets Mitochondrial endomycin nucleotide transferase (ANT). Glutathione arsenoxide causes cell proliferation arrest and cell death. Glutathione arsenoxide can be used to identify cell-surface proteins, such as Protein disulphide isomerase .

HY-174781

Human ACVRL1 mRNA	mRNA	Cancer
Human ACVRL1 mRNA encodes the human activin A receptor like type 1 (ACVRL1) protein. ACVRL1 is a type I cell-surface receptor for the TGF-beta superfamily ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development.

HY-P5487

GluR23Y	iGluR	Others
GluR23Y is a biological active peptide. (This GluR23Y peptide was used in ELISA cell-surface assay for the insulin-stimulated endocytosis of native AMPA receptors in cultured hippocampal neurons. GluR23Y prevented any insulin-induced reduction. The blockade of insulin action was observed when the GluR23Y peptide was delivered into neurons by fusing it to the membrane transduction domain of HIV-1.)

HY-134884

INCB086550 1 Publications Verification PD-1/PD-L1-IN-8	PD-1/PD-L1	Cancer
INCB086550 is a potent, oral, small-molecule PD-L1 inhibitor with IC_50s value of 3.1, 4.9 and 1.9 nM for human, cynomolgus, and rat, respectively. INCB086550 promotes the dimerization of cell-surface PD-L1 and induces PD-L1 entry into Golgi vesicles then traffick to the nucleus. INCB086550 can be used for multiple cancers research .

HY-P4523

FA-Ala-Arg	Endogenous Metabolite	Endocrinology
FA-Ala-Arg is a dipeptide with furylacryloyl group. FA-Ala-Arg breaks down to produce arginine. While cell-surface Carboxypeptidase-D (CPD) also increases intracellular Arg, which is converted to nitric oxide (NO). FA-Ala-Arg enhances NO production in MCF-7 cells. FA-Ala-Arg also increases the cell survival of prolactin (PRL)-treated cells, PRL regulates CPD mRNA levels in cells .

HY-D1598

Sulfo-CY3 tetrazine potassium	Fluorescent Dye	Others
Sulfo-CY3 tetrazine potassium is a sulfo-Cyanine3 derivative that contains methyltetrazine moiety (Ex=548 nm, Em=563 nm). Sulfo-CY3 tetrazine potassium can be used for the labeling of metabolically engineered cell-surface glycoconjugates . Sulfo-CY3 tetrazine (potassium) is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.

HY-P991611

ART5803	iGluR	Inflammation/Immunology
ART5803 is a humanized IgG1 monoclonal antibody inhibitor targeting NMDAR. ART5803 binds to the N-terminal domain (NTD) of the NMDAR GluN1 subunit (GluN1-NTD) with a high affinity. ART5803 blocks NMDAR internalization induced by pathogenic autoantibodies and restores cell-surface NMDAR expression and functions. ART5803 reverses behavioral abnormalities and NMDAR expression in marmoset disease models. ABT-147 can be used to study anti-NMDAR encephalitis .

HY-P99109

Zimberelimab GLS-010; AB-122; WBP-3055	PD-1/PD-L1	Cancer
Zimberelimab (GLS-010) is a fully human IgG4 anti-PD-1 monoclonal antibody with an EC₅₀ of 210 pM for human PD-1. Zimberelimab effectively blocks the binding of PD-L1 and PD-L2 to cell-surface PD-1 in CHO-S cells, with IC₅₀ values of 580 pM and 670 pM, respectively. Zimberelimab shows antitumor activities, and can be used for various cancers research, including cervical cancer, non-small cell lung cancer and classical Hodgkin’s lymphoma .

HY-P99829

Cofetuzumab pelidotin PF-06647020; ABBV-647; h6M24-vc0101	Antibody-Drug Conjugates (ADCs) Microtubule/Tubulin	Cancer
Cofetuzumab pelidotin (PF-06647020) is a PTK7-targeting ADC comprising a humanized anti-PTK7 mAb (hu6M024, IgG1) joined to an auristatin microtubule inhibitor payload, auristatin-0101 (Aur0101; HY-12522), by a cleavable valine-citrulline (vc)-based linker. Cofetuzumab pelidotin has a DAR of 4. Cofetuzumab pelidotin binds to cell-surface PTK7 with an EC₅₀ of 1153 pM by flow cytometry. Cofetuzumab pelidotin has the potential for solid tumors research .

HY-171859

FC-14367	PROTACs HIV	Cancer
FC-14367 is a PROTAC degrader targeting HIV-1 Nef protein. FC-14367 forms a ternary complex by binding Nef and Cereblon E3 ubiquitin ligase, inducing Nef ubiquitination and proteasomal degradation, restoring cell-surface CD4 and MHC-I expression and inhibiting HIV-1 replication. FC-14367 can be used in research on HIV infection and AIDS . (Black: Glycolic acid (HY-W015967); Blue: 2-(2,6-Dioxopiperidin-3-yl)phthalimidine (HY-138793))

HY-171860

FC-14369	PROTACs HIV	Cancer
FC-14369 is a PROTAC degrader targeting HIV-1 Nef protein with a DC₅₀ value of 160 nM. FC-14369 binds to both Nef and Cereblon E3 ubiquitin ligase via its bifunctional structure, inducing Nef ubiquitination and proteasomal degradation to restore cell-surface CD4 and MHC-I expression and inhibit HIV-1 replication. FC-14369 can be used in research on HIV infection and AIDS . (Pink: Nef ligand-2 (HY-171862); Black: Ethylenediamine (HY-Y0275); Blue: Thalidomide (HY-14658))

HY-P99573

Tebotelimab MGD-013	LAG-3	Inflammation/Immunology Cancer
Tebotelimab (MGD-013) is a humanized IgG4κ bispecific PD-1/LAG-3 dual-affinity re-targeting (DART) antibody. Tebotelimab binds cell-surface expressed PD-1 and LAG-3 with EC₅₀s of 1.65 nM and 0.41 nM in NS0 cells, respectively. Tebotelimab blocks PD-1/PD-L1, PD-1/PD-L2 and LAG-3/HLA (MHC-II) interactions and PD-1 signaling. Tebotelimab restores exhausted T-cell responses and and enhances antitumour immunity .

HY-E70234

Sortase A, S. aureus 1 Publications Verification SrtA	Bacterial	Others
Sortase A, S. aureus (SrtA), a transpeptidase enzyme is present in many Gram-positive bacteria and helps in the recruitment of the cell surface proteins. Sortase A, S. aureus plays an important part in ligation of various molecules on the cell surfaces .

HY-N12918

Lewis X tetrasaccharide	Others	Infection
Lewis X tetrasaccharide is a cell surface glycan that can be used for diagnosis of microbial infections.

HY-E70234A

Sortase A, S. aureus (non-Ca²⁺-dependent)	Bacterial	Inflammation/Immunology
Sortase A, S. aureus (non-Ca ²⁺-dependent), a transpeptidase enzyme is present in many Gram-positive bacteria and helps in the recruitment of the cell surface proteins. Sortase A, S. aureus (non-Ca ²⁺-dependent) plays an important part in ligation of various molecules on the cell surfaces .

HY-D1399

Kdn probe-1	Fluorescent Dye	Others
Kdn probe-1 is a fluorescent Kdn probe and reveals the localization of AfS in vesicles at the cell surface.

HY-P4552

Hippuryl-Phe-Arg-OH	Angiotensin Receptor	Others
Hippuryl-Phe-Arg-OH is the active site on the cell surface of Angiotensin I converting enzyme (ACE) .

HY-P991708

Olsutamig	PSMA CD3	Cancer
Olsutamig is a bivalent humanized IgG4κ monoclonal antibody inhibitor targeting FOLH1/PSMA and CD3E. Olsutamig simultaneously binds to PSMA on the tumor cell surface and CD3E on the T cell surface, markedly activating T cells and thereby specifically killing prostate cancer cells .

HY-W332335

Sulfosuccinimidyl-6-(biotinamido)hexanoate sodium	Biochemical Assay Reagents	Others
Sulfosuccinimidyl-6-(biotinamido)hexanoate sodium is a protein crosslinker, and is a biotinylation reagentcan for labeling cell surface proteins .

HY-172479

DSPE-PEG2000-F3	Liposome	Cancer
DSPE-PEG2000-F3 is a PEG compound which composed of DSPE and a nucleolin targeting peptide (F3). F3 peptide can specifically bind to cell surface nucleolin and undergo an effective cell surface to nucleus transport. DSPE-PEG2000-F3 can be used for drug delivery .

HY-172479A

DSPE-PEG3400-F3	Liposome	Cancer
DSPE-PEG3400-F3 is a PEG compound which composed of DSPE and a nucleolin targeting peptide (F3). F3 peptide can specifically bind to cell surface nucleolin and undergo an effective cell surface to nucleus transport. DSPE-PEG3400-F3 can be used for drug delivery .

HY-172478

DSPE-PEG1000-F3	Liposome	Cancer
DSPE-PEG1000-F3 is a PEG compound which composed of DSPE and a nucleolin targeting peptide (F3). F3 peptide can specifically bind to cell surface nucleolin and undergo an effective cell surface to nucleus transport. DSPE-PEG1000-F3 can be used for drug delivery .

HY-172480

DSPE-PEG5000-F3	Liposome	Cancer
DSPE-PEG5000-F3 is a PEG compound which composed of DSPE and a nucleolin targeting peptide (F3). F3 peptide can specifically bind to cell surface nucleolin and undergo an effective cell surface to nucleus transport. DSPE-PEG5000-F3 can be used for drug delivery .

HY-P9981

Tafasitamab 1 Publications Verification XmAb5574; MOR00208; Tafasitamab-cxix; MOR-208	Apoptosis	Inflammation/Immunology Cancer
Tafasitamab (XmAb5574) is an Fc-modified, humanized monoclonal antibody that binds to the human B-cell surface antigenCD19 .

HY-101916

Heparan Sulfate 15+ Cited Publications	FGFR Wnt Endogenous Metabolite	Neurological Disease Inflammation/Immunology Cancer
Heparan sulfate, a complex and linear polysaccharide, exists as part of glycoproteins named heparan sulfate proteoglycans, which are expressed abundantly on the cell surface and in the extracellular matrix.

HY-D2355

tris-NTA Biotin	Biochemical Assay Reagents	Others
tris-NTA Biotin is a biotin-labeled tris-NTA. tris-NTA Biotin can be used as a reversible probe to label proteins and cell surfaces reversibly .

HY-158002

IDOR-4	CFTR	Inflammation/Immunology
IDOR-4 is a type IV CFTR corrector. IDOR-4 restores F508del-CFTR trafficking to the cell surface .

HY-P4129

Rabies Virus Matrix Protein Fragment(RV-MAT)	nAChR	Others
Rabies Virus Matrix Protein Fragment (RV-MAT) is a polypeptide. Rabies Virus Matrix Protein Fragment targets the acetylcholine receptor (AChR) that exists on the cell surface .

HY-16657

TAPI-1 10+ Cited Publications	MMP	Inflammation/Immunology Cancer
TAPI-1 is a TACE (ADAM17) inhibitor and blocks the shedding of several cell surface proteins . TAPI-1 is also a metalloproteinase (MMP) inhibitor .

HY-W168754

DB28	MHC	Others
DB28 is a novel MR1 ligand. DB28 decreases cell surface expression of MR1 and competitively inhibits activation of MAIT cells by agonist ligands .

HY-P99023

Girentuximab 1 Publications Verification G250; cG250	Carbonic Anhydrase	Cancer
Girentuximab (G250) is a chimeric monoclonal antibody that binds carbonic anhydrase IX (CAIX), a cell surface glycoprotein ubiquitously expressed in clear cell renal cell carcinoma (ccRCC) .

HY-P990717

Brenetafusp IMC-F106C	CD3	Inflammation/Immunology
Brenetafusp is a type of TCR/anti-CD3 bispecific fusion protein. Brenetafusp targets intracellularly derived peptides presented at the tumor cell surface in complex with human leukocyte antigen (HLA) .

HY-P991540

AT008	CCR	Cancer
AT008 is an anti-GPCR monoclonal antibody that blocks the binding of chemokine ligands to its cell surface receptor CCR4. AT008 can be studied in research for certain haematological and solid cancers.

HY-124512

Quercetin pentaacetate Pentaacetylquercetin	RSV	Infection Inflammation/Immunology
Quercetin pentaacetate could interact with F-protein with lower binding energy and better stability to block viral adhesion. Quercetin pentaacetate interacts with RSV and inhibit the viral adhesion on cell surface .

HY-117856

IND24	Prion Protein	Infection
IND24 is a potent antiprion agent with an EC₅₀ value of 1.27 µM. IND24 decreases abnormal, misfolded, pathogenic forms of benign normally occurring prion protein on the cell surface or inside the cell .

HY-W133898

Tryptone	Biochemical Assay Reagents	Others
Tryptone is a peptide-rich bacterial culture medium component that can regulate bacterial cell surface proteins and biofilm-related genes. Tryptone promotes the expression and assembly of bacterial adhesion proteins (such as LapA and LapF) by providing peptide substances as structural factors, enhancing cell surface hydrophobicity and intercellular adhesion, thereby stabilizing the biofilm matrix and supporting the maturation and maintenance of bacterial biofilms. The peptide mixture contained in Tryptone can specifically regulate the transcription of bacterial adhesion-related genes (such as activating LapA and inhibiting LapF), affecting the synthesis and localization of biofilm structural proteins .

HY-118481

H-Pro-Glu-OH	Lipase	Infection
H-Pro-Glu-OH is a protein secreted by pathogenic mycobacteria through the Type VII secretion system. H-Pro-Glu-OH targets LipY lipases to the cell Surface via the ESX-5 Pathway .

HY-141598

Datopotamab deruxtecan 2 Publications Verification DS-1062; Dato-DXd	TROP2 Antibody-Drug Conjugates (ADCs) Topoisomerase	Cancer
Datopotamab deruxtecan (DS-1062; Dato-DXd) is a *trophoblast cell surface* antigen 2 (TROP2)-directed antibody-drug conjugate (ADC)**. Datopotamab deruxtecan has a potent antitumor activity .

HY-P3913

Acetyl-Adhesin (1025-1044) amide	Bacterial	Infection
Acetyl-Adhesin (1025-1044) amide is a 20-peptide fragment of Streptococcus pyogenes cell surface adhesin that acts as an antimicrobial peptide to specifically inhibit the binding of adhesin to salivary receptors and prevent recolonization of Streptococcus pyogenes .

HY-P3430

JM3A	Biochemical Assay Reagents	Cancer
JM3A is a highly specific peptoid reagent that targets newly appears cell surface vimentin (CSV) on tumor-transformed early lung cancer cells. JM3A can detect and stain CSV by coupling with fluorophores .

HY-175485

GaSal-2	Bacterial	Infection
GaSal-2 is a water-soluble anti-pseudomonal agent that targets the extracellular hemocyte HasAp. It binds tightly to HasAp, blocks the transcriptional activation of the bacterial cell surface signaling cascade, and inhibits the growth of Pseudomonas aeruginosa .

HY-122066

NSC47924	Others	Infection
NSC47924 is a laminin receptor (LR) inhibitor. NSC47924 affects 37/67 kDa LR cell surface localization and interaction with the cellular prion protein. NSC47924 can be used for testing prion diseases .

HY-145499

XTT sodium hydrate	Fluorescent Dye	Others
XTT is a cell-impermeable, negatively charged tetrazolium dye that produces a water-soluble formazan when reduced at the cell surface by cellular-derived NADH and an electron mediator. It is frequently used in colorimetric assays to measure cell proliferation, cytotoxicity, and apoptosis.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-101916

Heparan Sulfate Maximum Cited Publications 16 Publications Verification	Polysaccharides Neurological Disease Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields Saccharides	FGFR Wnt Endogenous Metabolite
Heparan sulfate, a complex and linear polysaccharide, exists as part of glycoproteins named heparan sulfate proteoglycans, which are expressed abundantly on the cell surface and in the extracellular matrix.

HY-W008859

Tetrac 1 Publications Verification Tetraiodothyroacetic acid; 3,3',5,5'-Tetraiodothyroacetic acid	Monophenols Classification of Application Fields Ketones, Aldehydes, Acids Source classification Phenols Endogenous metabolite Disease Research Fields Cancer	Integrin Endogenous Metabolite
Tetrac (Tetraiodothyroacetic acid), a derivative of L-thyroxine (T4), is a thyrointegrin receptor antagonist. Tetrac blocks the actions of T4 and 3,5,3'-triiodo-L-thyronine (T3) at the cell surface receptor for thyroid hormone on integrin αvβ3. Tetra has anti-angiogenic and anti-tumor activities .

HY-B0633A

Hyaluronic acid 10+ Cited Publications Hyaluronan; Hyaluronate	Zea mays L. Classification of Application Fields Source classification Moisture Plants Endogenous metabolite Human Gut Microbiota Metabolites Polysaccharides Gramineae Cosmetic Research Disease Research Fields Saccharides Cancer	Endogenous Metabolite Bacterial Akt PI3K
Hyaluronic acid is a biopolymer composed of repeating units of disaccharides with various applications. Hyaluronic acid is a major component of the extracellular matrix (ECM). Hyaluronic acid is synthesized at the plasma membrane. Increased hyaluronic acid levels are associated with tumor cell growth, adhesion, migration, invasion and angiogenesis in digestive cancers. Hyaluronic acid participates in tissue remodeling and rapid cell proliferation in some physiological processes including embryonic morphogenesis and wound-healing. Hyaluronic acid activates the PI3K-Akt signaling. Hyaluronic acid acts as a regulator of cancer-associated lymphangiogenesis. Hyaluronic acid also enhances cell invasion and angiogenesis by promoting proteolytic MMP-9 binding to cell surface or stimulating MMP-9 binding to cell surface. Hyaluronic acid can be used as drug delivery for sodium butyrate to improve the anti-proliferative activity on breast cancer cell line. Hyaluronic acid can be studied in joint diseases, wound healing and cancer .

HY-B0633

Hyaluronic acid sodium 10+ Cited Publications Sodium hyaluronate	Microorganisms Animals Classification of Application Fields Source classification Cosmetic Research Disease Research Fields Saccharides Cancer	Endogenous Metabolite Bacterial PI3K Akt
Hyaluronic acid sodium (Sodium hyaluronate) is a biopolymer composed of repeating units of disaccharides with various applications. Hyaluronic acid sodium is a major component of the extracellular matrix (ECM). Hyaluronic acid sodium is synthesized at the plasma membrane. Increased hyaluronic acid sodium levels are associated with tumor cell growth, adhesion, migration, invasion and angiogenesis in digestive cancers. Hyaluronic acid sodium participates in tissue remodeling and rapid cell proliferation in some physiological processes including embryonic morphogenesis and wound-healing. Hyaluronic acid sodium activates the PI3K-Akt signaling. Hyaluronic acid sodium acts as a regulator of cancer-associated lymphangiogenesis. Hyaluronic acid sodium also enhances cell invasion and angiogenesis by promoting proteolytic MMP-9 binding to cell surface or stimulating MMP-9 binding to cell surface. Hyaluronic acid sodium can be used as drug delivery for sodium butyrate to improve the anti-proliferative activity on breast cancer cell line. Hyaluronic acid sodium can be studied in joint diseases, wound healing and cancer .

HY-W415798

Ac4GalNAlk	Natural Products Classification of Application Fields Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Ac4GalNAlk is a weakly alkyne-labeled reagent for metabolic oligosaccharide engineering (MOE) that can be used to detect protein glycosylation. MOE reagents can be activated by cellular biosynthetic machinery into nucleotide sugars, which can be further traced through the introduction of glycoproteins in bioorthogonal chemistry. Ac4GalNAlk promotes nucleotide-sugar biosynthesis and increases bioorthogonal cell surface markers .

HY-122485

α-Copaene	Natural Products Classification of Application Fields Leguminosae Source classification Other Diseases Sindora Plants Disease Research Fields	Bacterial
α-Copaene is a potent attractant for male Mediterranean fruit flies Ceratitis capitata.α-Copaene can be found as a minor component in the essential oils of various plant species. α-Copaene can inhibit bacterial growth with a minimum inhibitory concentration of 0.5-1 μL/mL. α-Copaene suppresses biofilm formation by decreasing the hydrophobicity of the cell surface. α-Copaene can be used as an oviposition promoter of Bactrocera oleae .

HY-N2055

Kaempferol 3-O-sophoroside	Panax ginseng C. A. Meyer Flavonols Flavonoids other families Classification of Application Fields Source classification Phenols Polyphenols Plants Inflammation/Immunology Disease Research Fields Araliaceae	Toll-like Receptor (TLR) NF-κB TNF Receptor AMPK
Kaempferol 3-O-sophoroside is an orally active derivative of Kaempferol. It exhibits anti-inflammatory, analgesic, and antidepressant effects. Kaempferol 3-O-sophoroside is an inhibitor of the cell surface receptor toll-like receptor (TLR) 2/4 for High mobility group box 1 (HMGB1), and it also exerts anti-inflammatory effects by blocking the activation of NF-κB expression and the production of TNF-α. Kaempferol 3-O-sophoroside promotes the production of brain-derived neurotrophic factor (BDNF) and enhances autophagy by binding to AMP-activated protein kinase (AMPK), thereby exerting antidepressant effects. Kaempferol 3-O-sophoroside holds promise for research in the fields of inflammation and neurodegenerative diseases .

HY-N12918

Lewis X tetrasaccharide	Polysaccharides Animals Source classification Saccharides	Others
Lewis X tetrasaccharide is a cell surface glycan that can be used for diagnosis of microbial infections.

HY-W008859R

Tetrac (Standard)	Monophenols Ketones, Aldehydes, Acids Source classification Phenols Endogenous metabolite	Integrin Endogenous Metabolite
Tetrac (Tetraiodothyroacetic acid), a derivative of L-thyroxine (T4), is a thyrointegrin receptor antagonist. Tetrac blocks the actions of T4 and 3,5,3'-triiodo-L-thyronine (T3) at the cell surface receptor for thyroid hormone on integrin αvβ3. Tetra has anti-angiogenic and anti-tumor activities .

HY-N15776

C24:1 GD2 Ceramide (d18:1/24:1)	Lipid	Biochemical Assay Reagents
C24:1 GD2 Ceramide (d18:1/24:1) is a sphingoid base linked to a fatty acid. C24:1 GD2 Ceramide (d18:1/24:1) interacts with other membrane lipids and allows GD2 to be tightly anchored to the cell surface .

Cat. No.	Product Name	Chemical Structure

HY-15448S

Tezacaftor-d4
Tezacaftor-d4 (VX-661-d4) is the deuterium-labeled Tezacaftor (HY-15448), a F508del CFTR corrector. Tezacaftor helps CFTR protein reach the cell surface .

HY-15448S1

Tezacaftor-d6

Tezacaftor-d₆ (VX-661-d₆) is deuterium labeled Tezacaftor. Tezacaftor (VX-661) is a F508del CFTR corrector. It helps CFTR protein reach the cell surface. However, Ivacaftor (VX-770, HY-13017), a CFTR potentiator, helps to prolong the opening time of cell surface CFTR protein channels. Tezacaftor combining with Ivacaftor, shows potent efficacy against cystic fibrosis and diseases with homozygous for the CFTR Phe508del mutation. Moreover, Elexacaftor (VX-445, HY-111772) is also a CFTR corrector. Elexacaftor-Tezacaftor-Ivacaftor aims at with cystic fibrosis (CF) with at least one Phe508del mutation, often avoids the indication for lung transplantation .

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