Anti-Mesothelin Antibody (YP218)

Cat. No.: HY-P990833 Purity: 95.00%: Data Sheet
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Anti-Mesothelin Antibody (YP218) is a kind of rabbit IgG chimeric antibody, targeting to human Mesothelin. Anti-Mesothelin Antibody (YP218) reacts with a epitope in the C-terminal end close to the tumor cell surface of human mesothelin (MSLN). Anti-Mesothelin Antibody (YP218) can be used for the research of cancer, such as A431/H9 tumor.

For research use only. We do not sell to patients.

Anti-Mesothelin Antibody (YP218) Chemical Structure

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Description

Isotype

Rabbit IgG

Recommend Isotype Controls

Rabbit IgG1 kappa, Isotype Control

Species Reactivity

Human

IC₅₀ & Target

Mesothelin

In Vitro

Anti-Mesothelin Antibody (YP218) (humanized YP218 and IR700 conjugation) (3 μg/mL, 6 h) showed a high fluorescence signal in A431/H9 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Anti-Mesothelin Antibody (YP218) (humanized YP218 and IR700 conjugation) (100 μg, i.v., a single dose) inhibitss tumor growth companied with near infrared-photoimmunotherapy in A431/H9 tumor mice (athymic nude mice)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	A431/H9 tumor mice (6-8 weeks, female homozygote athymic nude mice)^[1]
Dosage:	100 μg (humanized YP218 and IR700 conjugation)
Administration:	Intravenously injection
Result:	Showed higher fluorescence intensity.

Gene ID

56047 [NCBI]

Accession

Q61468

Application

ELISA, FACS, Functional assay, Research in vivo

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Molecular Weight

150 kDa

Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Anti-Mesothelin Antibody (YP218)]

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Purity: 95.00%

Select Batch:

Data Sheet (257 KB) SDS (251 KB)

COA (232 KB)

Inhibitory Antibodies User Guide (602 KB)

References

[1]. Nagaya T, et al. Near infrared photoimmunotherapy with an anti-mesothelin antibody. Oncotarget. 2016 Apr 26;7(17):23361-9. [Content Brief]

Anti-Mesothelin Antibody (YP218) Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mesothelin Antibody (YP218)MesothelinMSLNA431/H9Inhibitorinhibitorinhibit

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