2. Signaling Pathways
  3. Immunology/Inflammation
  4. Mesothelin

Mesothelin

MSLN

Mesothelin is a cell surface glycoprotein that is normally expressed at low levels on mesothelial cells. Mesothelin is overexpressed in several types of cancers, including mesothelioma, ovarian cancer, and pancreatic cancer. Mesothelin can interact with other molecules such as megakaryocyte potentiating factor (MPF) and play roles in cell adhesion, migration and signal transduction. Mesothelin is an important target for cancer immunotherapy and diagnosis due to its differential expression in cancer cells[1][2][3].

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-P99006
    Amatuximab
    		Inhibitor 99.90%
    Amatuximab (MORab-009) is a chimeric, humanized IgG1/k MAb that targets the cell surface mesothelin (MSLN). Mesothelin is a glycosylphosphatidyl inositol (GPI)-anchored membrane glycoprotein, which is present in a restricted set of normal adult tissues such as the mesothelium.
    Amatuximab
  • HY-P99352
    Anetumab
    		Inhibitor 98.78%
    Anetumab (Anti-MSLN Antibody) is a fully humanized anti mesothelin (MSLN) IgG1 antibody. Anetumab (Anti-MSLN Antibody) can be used to synthesize the ADC molecule Anetumab ravtansine (HY-141606). Anetumab (Anti-MSLN Antibody) can be used for the research of cancer.
    Anetumab
  • HY-P990833
    Anti-Mesothelin Antibody (YP218)
    		Inhibitor
    Anti-Mesothelin Antibody (YP218) is a kind of rabbit IgG chimeric antibody, targeting to human Mesothelin.
    Anti-Mesothelin Antibody (YP218)
  • HY-P991456
    LMB-100
    		Inhibitor
    LMB-100 is a human immunotoxin targeting MSLN/Mesothelin. LMB-100 induces systemic inflammation and CD8 T cell recruitment. LMB-100 enhances the antitumor effects of anti-PD-1 antibodies in a human peripheral blood mononuclear cell transplanted mesothelioma mouse model and a syngeneic lung adenocarcinoma mouse model expressing human mesothelin. LMB-100 can be used in mesothelioma research. Recommended isotype control: Fab fused with a fragment of Pseudomonas exotoxin A.
    LMB-100
  • HY-171269
    Anetumab-MMAE
    Anetumab-MMAE is an antibody-drug conjugate (ADC) (Anetumab antibody (HY-P99352), Linker: VC linker, Payload: MMAE (HY-15162)). Anetumab is an anti-mesothelin (MSLN) antibody.
    Anetumab-MMAE
  • HY-P991189
    AMG-305
    		Inhibitor
    AMG-305
  • HY-P990466
    Anti-Mesothelin Antibody
    		Inhibitor
    Anti-Mesothelin Antibody is a humanized antibody expressed in CHO that targets Mesothelin. The Anti-Mesothelin Antibody has a huIgG1 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 150 kDa. For isotype control of the Anti-Mesothelin Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
    Anti-Mesothelin Antibody
  • HY-P990929
    Misitatug
    		99.00%
    HY-P990929 is an MSLN-targeting IgG1κ type chimeric antibody, the recommed isotype control is Human IgG1 kappa, Isotype Control (HY-P99001).
    Misitatug
Cat. No. Product Name / Synonyms Application Reactivity