Anti-GPC3 Antibody (YP7) 

Anti-GPC3 Antibody (YP7) is a kind of mouse IgG1 κ chimeric antibody, targeting to human GPC3. Anti-GPC3 Antibody (YP7) reacts with the C-lobe of cell surface-associated glypican-3 (GPC3). Anti-GPC3 Antibody (YP7) can be used for the research of cancer, such as hepatocellular carcinoma (HCC)^[1][2].

Mouse IgG1 kappa

Human

GPC3

Anti-GPC3 Antibody (YP7) (1 μg/mL) has excellent binding affinity and specificity for the native form of GPC3 in hepatocellular carcinoma (HCC) and other GPC3-expressing cancers^[1].
Anti-GPC3 Antibody (YP7) (IR700-YP7, IR700 and YP7 conjugation) (10 μg/mL, 6 h) induces lysosome swelling, budding and rupture in A431/G1 cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-GPC3 Antibody (YP7) (5 mg/kg, i.v., twice a week for 2 weeks) inhibits tumor growth in HepG2 tumor BALB/c nude mice^[1].
Anti-GPC3 Antibody (YP7) (IR700-YP7, IR700 and YP7 conjugation) (100 μg, i.v.) inhibits tumor growth companied with NIR light in A431/G1 tumor mice (homozygote athymic nude mice)^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

14734  [NCBI]

P51654

ELISA, FACS, Functional assay, Research in vivo

Unconjugated

The product can be reconstituted/diluted with sterile PBS or saline.

150 kDa

Liquid

Colorless to light yellow

[Anti-GPC3 Antibody (YP7)]

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Phung Y, et al. High-affinity monoclonal antibodies to cell surface tumor antigen glypican-3 generated through a combination of peptide immunization and flow cytometry screening. MAbs. 2012 Sep-Oct;4(5):592-9.  [Content Brief]

  [2]. Hanaoka H, et al. Photoimmunotherapy of hepatocellular carcinoma-targeting Glypican-3 combined with nanosized albumin-bound paclitaxel. Nanomedicine (Lond). 2015;10(7):1139-47.  [Content Brief]