Mucin 1 Antibody (YA5526)

Mucin 1 Antibody (YA5526) is a mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Mucin 1. It can be applicated for IHC-P, WB, ICC/IF, ELISA assays, in the background of human.

CD227 is a protein with cell adhesive properties. Its alpha subunit can function both as an adhesion and anti-adhesion protein, potentially forming a protective layer on epithelial cells against bacterial and enzymatic attack. The beta subunit contains a C-terminal domain involved in cell signaling, modulating pathways such as ERK, SRC, and NF-kappa-B through phosphorylations and protein-protein interactions. In activated T-cells, it directly or indirectly influences the Ras/MAPK pathway, promoting tumor progression. Additionally, CD227 regulates TP53-mediated transcription and determines cell fate during genotoxic stress response. It binds the PE21 promoter element of TP53 together with KLF4, repressing TP53 activity.

P15941

Predicted band size: 122 kDa; Observed band size: 122 kDa

Protein G

Non-conjugated

Unmodified

Primary Antibody; Mouse Monoclonal Antibody

Monoclonal

Mouse

Human

IHC: 1:200-1000; WB: 1:500-2000; ICC/IF: 1:100-500; ELISA: 1:1000-5000

IHC-P, WB, ICC/IF, ELISA

Liquid

Supplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG1

Synthesized peptide derived from human Epithelial Membrane Antigen(MUC1) AA range: 100-200