CD33 Antibody (YA4780)

CD33 Antibody (YA4780) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to CD33.

CD33 is a sialic-acid-binding immunoglobulin-like lectin (Siglec) involved in mediating cell-cell interactions and maintaining immune cells in a resting state. It preferentially recognizes and binds alpha-2,3- and more avidly alpha-2,6-linked sialic acid-bearing glycans. Upon ligand engagement (e.g., C1q or sialylated glycoproteins), two immunoreceptor tyrosine-based inhibitory motifs (ITIMs) in its cytoplasmic tail are phosphorylated by Src-like kinases (e.g., LCK), recruiting and activating protein-tyrosine phosphatases PTPN6/SHP-1 and PTPN11/SHP-2. These phosphatases regulate downstream pathways by dephosphorylating signaling molecules. One inhibitory effect of CD33 on monocyte activation requires phosphoinositide 3-kinase/PI3K.

P20138

Predicted band size: 40 kDa;

affinity purified.

Non-conjugated

Unmodified

Primary Antibody; Mouse Monoclonal Antibody

Monoclonal

Mouse

Human

WB: 1:500-1:2000; ELISA: 1:10000

WB, ELISA

Liquid

Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

Purified recombinant fragment of CD33 (48-258) expressed in E. Coli.