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Results for "

RA

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (2) ADC Antibody (1) Adenosine Receptor (6) Akt (3) AMPK (1) Amyloid-β (2) Antifolate (1) Apoptosis (12) Arenavirus (1) Arp2/3 Complex (1) Arrestin (1) Autophagy (7) Bacterial (15) Bcl-2 Family (4) Beta-secretase (1) Biochemical Assay Reagents (1) Btk (3) c-Fms (4) c-Myc (1) C-type Lectin-like Receptors (CTLRs) (2) CaMK (1) Carbonic Anhydrase (1) Casein Kinase (1) Cathepsin (1) CCR (2) CD6 (1) CHIKV (2) ClpP (1) Collagen (1) Complement System (2) COX (5) CXCR (2) Cytochrome P450 (8) Deubiquitinase (1) Dihydroorotate Dehydrogenase (1) DNA-PK (1) DNA/RNA Synthesis (3) Drug Derivative (3) Drug Intermediate (2) Drug Metabolite (2) E1/E2/E3 Enzyme (2) Endogenous Metabolite (4) Endothelin Receptor (3) Epigenetic Reader Domain (2) Estrogen Receptor/ERR (1) Flavivirus (1) Fluorescent Dye (1) G Protein-coupled Receptor Kinase (GRK) (1) GCGR (1) GLP Receptor (1) GLUT (2) Histamine Receptor (12) Histone Acetyltransferase (1) Influenza Virus (1) Interleukin Related (38) IRAK (2) Isotope-Labeled Compounds (3) JAK (1) Keap1-Nrf2 (1) LPL Receptor (1) mAChR (2) MDM-2/p53 (1) MMP (3) mRNA (14) Neuropeptide Y Receptor (1) NF-κB (2) NO Synthase (2) Notch (1) Nucleoside Antimetabolite/Analog (8) Opioid Receptor (1) p38 MAPK (5) Parasite (2) PGE synthase (1) Phosphatase (1) Phosphodiesterase (PDE) (2) PI3K (2) Potassium Channel (1) Proteasome (2) Protein Arginine Deiminase (4) Radionuclide-Drug Conjugates (RDCs) (1) RAR/RXR (14) Reactive Oxygen Species (ROS) (4) Reference Standards (12) ROR (1) SARS-CoV (1) SGLT (2) Sigma Receptor (2) Sirtuin (1) Small Interfering RNA (siRNA) (43) STAT (1) Tau Protein (1) TNF Receptor (6) Toll-like Receptor (TLR) (2) Transmembrane Glycoprotein (3) TRP Channel (1) VEGFR (3) Virus Protease (2) Wnt (1)
By Research Areas:	Cancer (60) Cardiovascular Disease (15) Endocrinology (8) Infection (25) Inflammation/Immunology (137) Metabolic Disease (19) Neurological Disease (17)
Click Chemistry:	DBCO (1)
Oligonucleotides:	Adenosine (4) Nucleoside Phosphoramidites (5) Nucleoside Analogs (4) Rat Pre-designed siRNA Sets (13) Adenine (5) Mouse Pre-designed siRNA Sets (14) mRNA (14) Human Pre-designed siRNA Sets (16) Antisense Oligonucleotides (3) siRNAs (43)

264

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Peptides

Inhibitory Antibodies

Natural
Products

181

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-161762

RA-0002034 RA-2034	CHIKV Virus Protease	Infection
RA-0002034 is a Chikungunya virus (CHIKV) nsP2 protease inhibitor with an IC₅₀ of 58 nM. RA-0002034 covalently modifies the catalytic cysteine in a site-specific manner .

HY-136528

RA-9	Deubiquitinase Apoptosis	Cancer
RA-9 is a potent and selective proteasome-associated deubiquitinating enzymes (DUBs) inhibitor with favorable toxicity profile and anticancer activity. RA-9 blocks ubiquitin-dependent protein degradation without impacting 20S proteasome proteolytic activity. RA-9 selectively induces onset of apoptosis in ovarian cancer cell lines and primary cultures derived from donors. RA-9 induces endoplasmic reticulum (ER)-stress responses in ovarian cancer cells .

HY-136563

RA375	Proteasome Apoptosis Reactive Oxygen Species (ROS)	Cancer
RA375 is a RPN13 (26S proteasome regulatory subunit) inhibitor. RA375 activates UPR signaling, ROS production and apoptosis. RA375 exhibits ten-fold greater activity against cancer lines than RA190, reflecting its nitro ring substituents and the addition of a chloroacetamide warhead .

HY-N10790

RA-V	Wnt c-Myc Notch	Cancer
RA-V is a cyclic hexapeptide. RA-V has activity against Wnt, Myc and Notch with IC₅₀ values of 50, 75, and 93 ng/mL, respectively. RA-V can be used for the research of cancer-related signaling pathways .

HY-173117

RA306	CaMK	Cardiovascular Disease Cancer
RA306 is an orally active CAMK2 inhibitor. RA306 can block the PEAK1/CAMK2 signaling pathway. RA306 inhibits the proliferation, migration, and invasion of breast cancer cells and has anti-tumor activity. In addition, RA306 can improve dilated cardiomyopathy in mice and can be used in the research of heart diseases .

HY-110275

RA839	Keap1-Nrf2 NO Synthase	Infection Inflammation/Immunology
RA839 is a selective Nrf2/ARE pathway agonist and non-covalent small molecule binder of Keap1 (K_d is approximately 6 μM). RA839 prevents inducible nitric oxide synthase expression and nitric oxide release. RA839 exerts anti-rotaviral and anti-inflammatory effects .

HY-N10793

RA-XI	Others	Cancer
RA-XI is a bicyclic hexapeptide isolated from Rubia cordifolia with antitumour activity .

HY-118689

RA-2	Potassium Channel	Cardiovascular Disease Neurological Disease Inflammation/Immunology
RA-2 is a negative-gating modulator of KCa2/3 channels with an IC₅₀ of 17 nM. RA-2 inhibits bradykinin-induced endothelium-derived hyperpolarization (EDH)-type relaxation in U46619-precontracted rings. RA-2 can help to define the physiologic and pathomechanistic roles of KCa2/3 in the vasculature, central nervous system, and during inflammation .

HY-123019

RA-263	Nucleoside Antimetabolite/Analog	Cancer
RA-263, a 2-nitroimidazole nucleoside, is an effective radiosensitizer .

HY-162707

RA-0002323-01	Others	Infection
RA-0002323-01 is an antiviral agent targeting viral helicase and is an active compound from Heli-SMACC, a collection of small molecules targeting helicase .

HY-100739

RA190 4 Publications Verification	Proteasome	Cancer
RA190, a bis-benzylidine piperidon, inhibits proteasome function by covalently binding to cysteine 88 of ubiquitin receptor RPN13.

HY-106618

Mopidamol RA 233	Phosphodiesterase (PDE)	Cancer
Mopidamol (RA 233), a derivative of Dipyridamole (HY-B0312), is a phosphodiesterase inhibitor. Mopidamol can be used for non-small cell lung cancer (N-SCLC) research .

HY-176268

SGC-NSP2hel-1 RA-0188293; RA-NSP2-1	Virus Protease Flavivirus	Infection
SGC-NSP2hel-1 (RA-0188293), a chemical probe, is a potent, specific and orally active nsP2 inhibitor. SGC-NSP2hel-1 has broad spectrum activity against multiple alphaviruses of the nsP2 helicase with a CC₅₀ > 250 μM. SGC-NSP2hel-1 (RA-0188293) shows selectivity index > 4000 against human RNA helicases. SGC-NSP2hel-1 reduces virus replication and limited virus-induced pathology by forming a stable complex with nsP2 and ATP in a preclinical small animal model of CHIKV disease.

HY-P3502

Zilucoplan RA101495; RA3193	Complement System	Inflammation/Immunology
Zilucoplan (RA101495), a 15-amino acid macrocyclic peptide, is a potent complement component 5 (C5) inhibitor. Zilucoplan can be used in research of immune-mediated necrotising myopathy (IMNM) .

HY-172176

RA-PR058	Beta-secretase Tau Protein	Neurological Disease
RA-PR058 is an orally active Ramalin derivative with blood-brain barrier permeability, exhibiting multi-target regulatory effects and favorable pharmacokinetic properties. RA-PR058 demonstrates potential as a multi-target modulator for Alzheimer's disease by reducing the expression of BACE1, tau protein hyperphosphorylation, and anxiety-like behaviors .

HY-P2045

RA-VII	Arp2/3 Complex	Cancer
RA-VII is an antitumor agent that exhibits significant activity against L1210, B-16 melanoma, Lewis lung carcinoma, Colon 38 and Ehrlich carcinoma .

HY-P3502A

Zilucoplan TFA RA101495 TFA; RA3193 TFA	Complement System	Inflammation/Immunology
Zilucoplan TFA (RA101495), a 15-amino acid macrocyclic peptide, is a potent complement component 5 (C5) inhibitor. Zilucoplan TFA can be used in research of immune-mediated necrotising myopathy (IMNM) .

HY-119291

RA642	Phosphodiesterase (PDE)	Others
RA642 is a compound with vasodilatory and hypertensive effects, with the activity of increasing arterial blood pressure, enhancing cerebral blood flow, reducing cerebrovascular resistance and peripheral resistance, and having a papaverine-like relaxant effect on smooth muscle in anesthetized animals.

HY-RS19373

Raly Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Raly Mouse Pre-designed siRNA Set A contains three designed siRNAs for Raly gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Raly Mouse Pre-designed siRNA Set A Raly Mouse Pre-designed siRNA Set A

HY-RS11635

RALY Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
RALY Human Pre-designed siRNA Set A contains three designed siRNAs for RALY gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

RALY Human Pre-designed siRNA Set A RALY Human Pre-designed siRNA Set A

HY-RS25865

Raly Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Raly Rat Pre-designed siRNA Set A contains three designed siRNAs for Raly gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Raly Rat Pre-designed siRNA Set A Raly Rat Pre-designed siRNA Set A

HY-101526

GENZ-882706 RA03546849	c-Fms	Inflammation/Immunology
GENZ-882706 is a potent colony stimulating factor-1 receptor (CSF-1R) Inhibitor extracted from patent WO 2017015267A1.

HY-14750

Rabeximod ROB-803	Toll-like Receptor (TLR)	Neurological Disease Inflammation/Immunology
Rabeximod (ROB-803), an anti-rheumatic compound, impairs the differentiation and function of human pro-inflammatory dendritic cells and macrophages via downregulating TLR2 and TLR4 stimulation. Rabeximod (ROB-803) is used for rheumatoid arthritis (RA) research .

HY-107644

AQ-RA 741	mAChR	Cardiovascular Disease
AQ-RA 741 is a potent and selective M 2 antagonist. AQ-RA 741 inhibits the vagally or agonist-induced bradycardia in rats, cats and guinea-pigs. AQ-RA 741 is used in bradycardiac disorders research .

HY-161762A

(E/Z)-RA-0002034 (E/Z)-RA-2034	Influenza Virus CHIKV	Cancer
(E/Z)-RA-0002034 is a Chikungunya virus (CHIKV) nsP2 protease inhibitor with IC50 of 58 nM. RA-0002034 covalently modifies the catalytic cysteine in a site-specific manner.

HY-116472

alpha-RA-F α-RA-F	Endogenous Metabolite	Others
alpha-RA-F (α-RA-F) is a compound that can promote collagen synthesis and has the activity of reducing the expression level of matrix metalloproteinases (MMPs). alpha-RA-F enhances collagen synthesis in human fibroblasts without causing cytotoxicity. alpha-RA-F has demonstrated its important potential in the pharmaceutical, pharmaceutical and cosmetic industries by regulating collagen synthesis and MMPs expression levels .

HY-P9923A

Benralizumab (anti-IL5RA ) MEDI-563 (anti-IL5RA ); BIW-8405 (anti-IL5RA )	Interleukin Related	Inflammation/Immunology
Benralizumab (anti-IL5RA ) (MEDI-563 (anti-IL5RA ); BIW-8405 (anti-IL5RA )) is an interleukin-5 receptor α (IL-5Rα)-directed cytolytic monoclonal antibody that induces direct, rapid and nearly complete depletion of eosinophils via enhanced antibody-dependent cell-mediated cytotoxicity. Benralizumab can be used for severe eosinophilic asthma study .

HY-50084

CCR2-RA	CCR	Cancer
CCR2-RA is a allosteric antagonist of chemokine (C-C motif) receptor 2 (CCR 2), and it can be used in cancer research .

HY-174643

Human IL11RA mRNA	mRNA	Inflammation/Immunology
Human IL11RA mRNA encodes the human interleukin 11 receptor subunit alpha (IL11RA) protein, a member of the hematopoietic cytokine receptor family. IL11RA is essential for the normal development of craniofacial bones and teeth.

HY-W006102

Bz-rA Phosphoramidite DMT-2'O-TBDMS-RA(bz) PhosphoRAmidite	DNA/RNA Synthesis Nucleoside Antimetabolite/Analog	Others
Bz-rA Phosphoramidite is used for ribonucleotides modification .

HY-174612

Human IL27RA mRNA	mRNA	Inflammation/Immunology
Human IL27RA mRNA encodes the human interleukin 27 receptor subunit alpha (IL27RA) protein, a protein that is similar to the mouse T-cell cytokine receptor (Tccr) at the amino acid level. IL27RA is predicted to be a glycosylated transmembrane protein.

HY-174611

Human IL2RA mRNA	mRNA	Inflammation/Immunology
Human IL2RA mRNA encodes the human interleukin 2 receptor subunit alpha (IL2RA) protein, a receptor for interleukin-2. IL2RA is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity.

HY-174623

Human IL20RA mRNA	mRNA	Inflammation/Immunology
Human IL20RA mRNA encodes the human interleukin 20 receptor subunit alpha (IL20RA) protein, a member of the type II cytokine receptor family. IL20RA is a subunit of the receptor for interleukin 20, a cytokine that may involve in epidermal function.

HY-N4260

Ginsenoside Ra2	Others	Inflammation/Immunology
Ginsenoside Ra2 is a component from Panax ginseng .

HY-107730

NPY5RA-972	Neuropeptide Y Receptor	Neurological Disease
NPY5RA-972 is an orally active, central nervous system (CNS) penetrating, potent and selective NPY Y5 receptor antagonist that prevents feeding driven by activation of this receptor .

HY-W114886

DMT-OMe-rA(Bz)	Nucleoside Antimetabolite/Analog	Others
DMT-OMe-rA(Bz) is a nucleoside analog .

HY-174605

Human IL3RA mRNA	mRNA	Inflammation/Immunology
Human IL3RA mRNA encodes the human interleukin 3 receptor subunit alpha (IL3RA) protein, an interleukin 3 specific subunit of a heterodimeric cytokine receptor.

HY-174733

Human CSF2RA mRNA	mRNA	Inflammation/Immunology
Human CSF2RA mRNA encodes the human colony stimulating factor 2 receptor subunit alpha (CSF2RA) protein, a cytokine that controls the production, differentiation, and function of macrophages.

HY-174619

Human IL22RA1 mRNA	mRNA	Inflammation/Immunology
Human IL22RA1 mRNA encodes the human interleukin 22 receptor subunit alpha 1 (IL22RA1) protein, a member of the class II cytokine receptor family. IL22RA1 has been shown to be a receptor for interleukin 22 (IL22).

HY-W008388

Bz-rA N6-Benzoyladenosine	Nucleoside Antimetabolite/Analog	Others
Bz-rA (N6-Benzoyladenosine) is a nucleoside derivative with an N6 protecting group. Bz-rA is mainly used as a synthetic intermediate to participate in photocatalytic oxidative cyclization reactions and synthesize oligoribonucleotides. Bz-rA can be used to efficiently construct heterocyclic skeletons in photochemical conversions and protect the ribose moiety to regulate the cyclization pathway .

HY-174601

Human IL5RA mRNA	mRNA	Inflammation/Immunology
Human IL5RA mRNA encodes the human interleukin 5 receptor subunit alpha (IL5RA) protein, an interleukin 5 specific subunit of a heterodimeric cytokine receptor. IL5RA has been found to interact with syndecan binding protein (syntenin), which is required for IL5 mediated activation of the transcription factor SOX4.

HY-W1008069

3'-TBS-OMe-Bz-rA	Drug Derivative Drug Intermediate	Others
3'-TBS-OMe-Bz-rA is an adenosine derivative. 3'-TBS-OMe-Bz-rA can be used as an intermediate in the synthesis of modified oligonucleotides or other nucleic acid-related molecules.

HY-18099A

S1RA hydrochloride 2 Publications Verification E-52862 hydrochloride	Sigma Receptor 5-HT Receptor	Neurological Disease
S1RA (E-52862) hydrochloride is an orally active and selective sigma-1 receptor (σ1R) antagonist with a K_i value of 17 nM. S1RA hydrochloride shows good selectivity against σ2R (K_i >1000 nM). S1RA hydrochloride is a human 5-HT2B receptor antagonist with an IC₅₀ value of 4.7 μM. S1RA hydrochloride inhibits neuropathic pain and activity-induced spinal sensitization .

HY-N4259

Ginsenoside Ra3	Endogenous Metabolite	Cancer
Ginsenoside Ra3, isolated from Panax ginseng, possesses anti-cancer activity .

HY-P991219

Anti-IL11RA Antibody (X209) EnX209	Interleukin Related	Inflammation/Immunology
Anti-IL11RA Antibody (X209) is a human-derived IgG4, κ type antibody inhibitor, targeting to human IL-11RA. Recommend Isotype Controls: Human IgG4 kappa, Isotype Control (HY-P99003).

HY-174618

Human IL22RA2 mRNA	mRNA	Inflammation/Immunology
Human IL22RA2 mRNA encodes the human interleukin 22 receptor subunit alpha 2 (IL22RA2) protein, a member of the class II cytokine receptor family. IL22RA2 may be important in the regulation of inflammatory response, and has been implicated in the regulation of tumorigenesis in the colon.

HY-174635

Human IL15RA mRNA	mRNA	Inflammation/Immunology
Human IL15RA mRNA encodes the human interleukin 15 receptor subunit alpha (IL15RA) protein, a cytokine receptor that specifically binds interleukin 15 (IL15) with high affinity. IL15RA is reported to enhance cell proliferation and expression of apoptosis inhibitor BCL2L1/BCL2-XL and BCL2.

HY-18099

S1RA 2 Publications Verification E-52862	Sigma Receptor 5-HT Receptor	Neurological Disease
S1RA (E-52862) is a highly selective σ1 receptor (σ1R) antagonist with K_is of 17 nM and 23.5 nM for human σ1R and guinea pig σ1R, respectively. S1RA has Moderate antagonistic activity for human 5-HT_2B receptor (K_i= 328 nM). S1RA has antinociceptive effects in neuropathic pain models. S1RA prevents mechanical and cold hypersensitivity in Oxaliplatin (HY-17371)-treated mice .

HY-174637

Human IL13RA2 mRNA	mRNA	Inflammation/Immunology
Human IL13RA2 mRNA encodes the human interleukin 13 receptor subunit alpha 2 (IL13RA2) protein, a subuint of the interleukin 13 receptor complex. IL13RA2 binds IL13 with high affinity, but lacks cytoplasmic domain, and does not appear to function as a signal mediator. It is reported to play a role in the internalization of IL13.

HY-174645

Human IL10RA mRNA	mRNA	Metabolic Disease
Human IL10RA mRNA encodes the human interleukin 10 receptor subunit alpha (IL10RA) protein, a receptor for interleukin 10. IL10RA been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. It is also reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N10790

RA-V	Structural Classification Cyclopeptides Source classification Rubiaceae Plants Rubia cordifolia L.	Wnt c-Myc Notch
RA-V is a cyclic hexapeptide. RA-V has activity against Wnt, Myc and Notch with IC₅₀ values of 50, 75, and 93 ng/mL, respectively. RA-V can be used for the research of cancer-related signaling pathways .

HY-N10793

RA-XI	Structural Classification Cyclopeptides Source classification Rubiaceae Plants Rubia cordifolia L.	Others
RA-XI is a bicyclic hexapeptide isolated from Rubia cordifolia with antitumour activity .

HY-N4260

Ginsenoside Ra2	Panax ginseng C. A. Meyer Triterpenes Classification of Application Fields Terpenoids Source classification Plants Disease Research Fields Inflammation/Immunology Araliaceae	Others
Ginsenoside Ra2 is a component from Panax ginseng .

HY-N4259

Ginsenoside Ra3	Panax ginseng C. A. Meyer Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Plants Disease Research Fields Araliaceae Cancer	Endogenous Metabolite
Ginsenoside Ra3, isolated from Panax ginseng, possesses anti-cancer activity .

HY-N2506

Ginsenoside Ra1	Cardiovascular Disease Panax ginseng C. A. Meyer Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Plants Disease Research Fields Araliaceae	Others
Ginsenoside Ra1 is a component from ginseng, inhibits protein tyrosine kinase (PTK) activation induced by hypoxia/reoxygenation .

HY-N12648

Anemarsaponin E1	Structural Classification Polysaccharides Liliaceae Source classification Anemarrhena asphodeloides Bunge Plants Saccharides	Others
Anemarsaponin E1 can be isolated from Guizhi-Shaoyao-Zhimu decoction (GSZD), and can be used for research of rheumatoid arthritis (RA), gout, osteoarthritis, etc .

HY-N12015

Ginsenoside Ra6 Ginsenoside IV	Panax ginseng C. A. Meyer Structural Classification Polysaccharides Source classification Plants Saccharides Araliaceae	Others
Ginsenoside Ra6 (Ginsenoside IV) is a panaxadiol-type ginsenoside that can be isolated from the roots of ginseng .

HY-N11957

Angeloylbinankadsurin A	Structural Classification Source classification Lignans Phenylpropanoids Plants Kadsura coccinea (Lem.) A. C. Smith Schisandraceae	Others
Angeloylbinankadsurin A (compound 7) is an anti-rheumatoid arthritis (RA) agent that can be isolated from EtOAc and CH2Cl2 extracts of Black Tiger Beard. Angeloylbinankadsurin A exhibits inhibitory activity on RA-FLS cells (IC₅₀=11.70 μM). Angeloylbinankadsurin A is slightly toxic to human cancer cell lines (Hela and BGC-823) (IC₅₀=19.9 μM, 21.93 μM) .

HY-N2876

Anisofolin A	Structural Classification Monophenols Flavonoids Flavones Labiatae Source classification Phenols Plants Artemisia persica Boiss.	Parasite Bacterial
Anisofolin A is a flavonoid that can be isolated from Anisomeles indica. Anisofolin A has antimalarial activity (IC₅₀: 4.39 μM), and antimycobacterium activity (IC₅₀: 4.50 μM) against M. tuberculosis H37Ra .

HY-N11646

Ganorbiformin B	Triterpenes Structural Classification Microorganisms Terpenoids Source classification	Bacterial
Ganorbiformin B is a lanostane triterpenoid. Ganorbiformin B shares the same lanostane skeleton with known ganoderic acids. The C-3 epimer of ganoderic acid T exhibits potent antimycobacterial activity against Mycobacterium tuberculosis H37Ra .

HY-N3612

Communic acid (+)-Communic acid	Structural Classification Animals Ketones, Aldehydes, Acids Source classification	Bacterial Akt MMP
Communic acid ((+)-Communic acid) is a natural compound isolated from the branches of Platycladus orientalis. Communic acid displays minimum inhibitory concentration of 31 μM and IC₅₀ of 15 μM against M. tuberculosis *H37Ra*.Communic acid exhibits protective effects against UVB-induced skin aging .

HY-N1440

Koumine	Alkaloids Structural Classification Classification of Application Fields Source classification Loganiaceae Plants Gelsemium eleganis (Gardn. et Champ.) Benth. Inflammation/Immunology Disease Research Fields Indole Alkaloids	Bcl-2 Family
Koumine is an alkaloid separated from Gelsemium elegans, shows potent anti-tumor activity. Koumine up-regulates the Bax/Bcl-2 ratio and caspase-3 expression in human breast cancer cells . Koumine has anxiolytic, antistress, antipsoriatic, and analgesic activities , protects against the development of arthritis in Rheumatoid arthritis (RA) animal models .

HY-135453

(-)-Pinocembrin	Structural Classification Flavonoids Flavones Polygonaceae Source classification Persicaria glabra (Willd.) M. Gomez Plants	Bacterial
(-)-Pinocembrin exhibits anti-mycobacterium activity against mycobacteriuum tuberculosis H37Ra with an IC₅₀ value of 1.11 mg/mL in dormant phase and 1.21 mg/mL in active phase, respectively. (-)-Pinocembrin has potent antiproliferative activity with IC₅₀ values of 1.88-11.00 mg/mL against THP-1, A549, Panc-1, HeLa and MCF7 cell lines .

HY-126640

Phomoxanthone A	Quinones Structural Classification Microorganisms Anthraquinones Source classification	Parasite
Phomoxanthone A is a xanthone dimer, which can be isolated from Phomopsis. Phomoxanthone A exhibits antimalarial and antitubercular activities against Plasmodium falciparum (K1, multidrug-resistant strain, IC₅₀ is 0.11 µg/mL) and Mycobacterium tuberculosis (H37Ra strain, MIC is 0.50 µg/mL). Phomoxanthone A exhibits cytotoxicity in cells KB, BC-1 and Vero, IC₅₀ is 0.99, 0.51 and 1.4 µg/mL, respectively .

HY-N1440R

Koumine (Standard)	Alkaloids Structural Classification Source classification Loganiaceae Plants Gelsemium eleganis (Gardn. et Champ.) Benth. Indole Alkaloids	Reference Standards Bcl-2 Family
Koumine (Standard) is the analytical standard of Koumine. This product is intended for research and analytical applications. Koumine is an alkaloid separated from Gelsemium elegans, shows potent anti-tumor activity. Koumine up-regulates the Bax/Bcl-2 ratio and caspase-3 expression in human breast cancer cells . Koumine has anxiolytic, antistress, antipsoriatic, and analgesic activities , protects against the development of arthritis in Rheumatoid arthritis (RA) animal models .

HY-N1976

(+)-(3R,8S)-Falcarindiol 1 Publications Verification (3R,8S)-Falcarindiol; 3(R),8(S),9(Z)-Falcarindiol	Infection Structural Classification Natural Products Classification of Application Fields Source classification Decachaeta ovatifolia (DC.) R.M.King & H.Rob. Umbelliferae Plants Inflammation/Immunology Disease Research Fields	Bacterial
(+)-(3R,8S)-Falcarindiol is a polyacetylene found in carrots, has antimycobacterial activity, with an IC₅₀ of 6 μM and MIC of 24 μM against Mycobacterium tuberculosis H37Ra . Antineoplastic and anti-inflammatory activity . (+)-(3R,8S)-Falcarindiol is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-N0142

Phloretin Maximum Cited Publications 20 Publications Verification NSC 407292; RJC 02792	Structural Classification Classification of Application Fields Source classification Rosaceae Plants Dihydrochalcones Endogenous metabolite Human Gut Microbiota Metabolites Flavonoids Microorganisms Malus pumila Mill. Phenols Polyphenols Disease Research Fields Cancer	SGLT Endogenous Metabolite GLUT
Phloretin (NSC 407292; RJC 02792) is a flavonoid extracted from Malus pumila Mill.，has anti-inflammatory activities. Phloridzin is a specific，competitive and orally active inhibitor of sodium/glucose cotransporters in the intestine (SGLT1) and kidney (SGLT2). Phloretin inhibits Yeast-made GLUT1 as well as Human erythrocyte GLUT1 with IC₅₀values of 49 μM and 61 μM，respectively .Phloretin has the potential for the treatment of rheumatoid arthritis (RA) and allergic airway inflammation .

HY-N0142R

Phloretin (Standard) NSC 407292 (Standard); RJC 02792 (Standard)	Structural Classification Human Gut Microbiota Metabolites Flavonoids Classification of Application Fields Malus pumila Mill. Source classification Rosaceae Phenols Plants Endogenous metabolite Disease Research Fields Cancer	Reference Standards SGLT Endogenous Metabolite GLUT
Phloretin (Standard) is the analytical standard of Phloretin. This product is intended for research and analytical applications. Phloretin (NSC 407292; RJC 02792) is a flavonoid extracted from Malus pumila Mill., has anti-inflammatory activities. Phloridzin is a specific, competitive and orally active inhibitor of sodium/glucose cotransporters in the intestine (SGLT1) and kidney (SGLT2). Phloretin inhibits Yeast-made GLUT1 as well as Human erythrocyte GLUT1 with IC₅₀values of 49 μM and 61 μM, respectively .Phloretin has the potential for the treatment of rheumatoid arthritis (RA) and allergic airway inflammation .

HY-N11650

(22S,24E)-3β,22-Diacetoxylanosta-7,9(11),24-trien-26-oic acid	Triterpenes Structural Classification Microorganisms Terpenoids Source classification	Bacterial
(22S,24E)-3β,22-Diacetoxylanosta-7,9(11),24-trien-26-oic acid (compound 15) is an antitubercular agent with MIC value of 12.5 μg/mL for Mycobacterium tuberculosis H37Ra. (22S,24E)-3β,22-Diacetoxylanosta-7,9(11),24-trien-26-oic acid shows cytotoxicity with IC₅₀ value of 32 μM for Vero cells .

HY-N2435

[8]-Shogaol 3 Publications Verification	Zingiber officinale Roscoe Structural Classification Monophenols Classification of Application Fields Source classification Phenols Plants Disease Research Fields Zingiberaceae Cancer	COX Apoptosis
[8]-Shogaol, a kind of stimulating compound in ginger, has antiplatelet (IC₅₀=5 μM), anti-cancer and anti-inflammatory activity. [8]-Shogaol inhibited COX-2 (IC₅₀=17.5 μM), which led to the decline of human leukemia cells. 8-Shogaol Selective direction TAK1 sum TAK1-TAB1 (IC₅₀=5 μM), suppress IKK, Akt sum MAPK signal pathway, and reverse synovitis synovial sum Air dampness (RA).

HY-N2435R

[8]-Shogaol (Standard)	Zingiber officinale Roscoe Structural Classification Monophenols Source classification Phenols Plants Zingiberaceae	Reference Standards COX Apoptosis
-Shogaol (Standard) is the analytical standard of -Shogaol. This product is intended for research and analytical applications. -Shogaol, a kind of stimulating compound in ginger, has antiplatelet (IC₅₀=5 μM), anti-cancer and anti-inflammatory activity. -Shogaol inhibited COX-2 (IC₅₀=17.5 μM), which led to the decline of human leukemia cells. 8-Shogaol Selective direction TAK1 sum TAK1-TAB1 (IC₅₀=5 μM), suppress IKK, Akt sum MAPK signal pathway, and reverse synovitis synovial sum Air dampness (RA) .

Cat. No.	Product Name	Chemical Structure

HY-B0524AS

Betahistine-d3 dihydrochloride
Betahistine-d₃ (dihydrochloride) is the deuterium labeled Betahistine dihydrochloride. Betahistine dihydrochloride is an orally active histamine H1 receptor agonist and a H3 receptor antagonist . Betahistine dihydrochloride is used for the study of rheumatoid arthritis (RA) .

HY-150658S

DMT-2′O-TBDMS-rA(ac)-1-15N phosphoramidite
DMT-2′O-TBDMS-rA(ac)-1- ¹⁵N phosphoramidite is the ¹⁵N labeled DMT-2′O-TBDMS-rA(ac) phosphoramidite .

HY-175310S

Voderdeucitinib
Voderdeucitinib (Compoudn I) is a TYK2 inhibitor with an anti-inflammatory activity. Voderdeucitinib can be used for inflammatory and autoimmune disease research, such as rheumatoid arthritis (RA), multiple sclerosis and intestinal bowel disease (IBD) .

HY-B0524AS1

Betahistine-13C,d3 dihydrochloride
Betahistine- ¹³C,d₃ (dihydrochloride) is the ¹³C- and deuterium labeled Betahistine (dihydrochloride). Betahistine dihydrochloride is an orally active histamine H1 receptor agonist and a H3 receptor antagonist . Betahistine dihydrochloride is used for the study of rheumatoid arthritis (RA) .

HY-B0160S

Lafutidine-d10
Lafutidine-d₁₀ is deuterium labeled Lafutidine. Lafutidine (FRG-8813) is a histamine H2-receptor antagonist (H2RA), with proven gastric mucosal protective effects. Lafutidine can be used for the research of gastroesophageal reflux disease .

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