Search Result

Results for "

rats.

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (47) Acyltransferase (4) Adenosine Kinase (1) Adenosine Receptor (3) Adrenergic Receptor (23) Akt (10) Aldehyde Dehydrogenase (ALDH) (5) Aldose Reductase (4) Amino Acid Derivatives (5) Aminopeptidase (3) AMPK (2) Amyloid-β (4) Androgen Receptor (5) Angiotensin Receptor (8) Angiotensin-converting Enzyme (ACE) (9) Antibiotic (7) Apolipoprotein (1) Apoptosis (61) Aryl Hydrocarbon Receptor (2) Atg8/LC3 (2) ATP Citrate Lyase (3) ATP Synthase (3) Autophagy (14) Bacterial (18) Bcl-2 Family (2) BCRP (1) Beta-secretase (2) Biochemical Assay Reagents (31) Bradykinin Receptor (2) c-Fms (1) c-Met/HGFR (3) Calcium Channel (16) Cannabinoid Receptor (4) Carbonic Anhydrase (8) Caspase (2) CaSR (1) CCR (4) CDK (1) Ceramidase (1) Cholecystokinin Receptor (4) Cholinesterase (ChE) (13) COMT (1) Constitutive Androstane Receptor (1) COX (8) CRFR (5) CXCR (1) Cyclic GMP-AMP Synthase (1) Cytochrome P450 (9) DNA/RNA Synthesis (3) Dopamine Receptor (25) Dopamine Transporter (5) Dopamine β-hydroxylase (1) Drug Derivative (9) Drug Intermediate (5) Drug Isomer (1) Drug Metabolite (14) E1/E2/E3 Enzyme (1) EGFR (2) Endogenous Metabolite (76) Endothelin Receptor (10) Enterovirus (4) Epoxide Hydrolase (2) ERK (7) Estrogen Receptor/ERR (14) FAAH (1) Factor Xa (1) Fatty Acid Synthase (FASN) (1) Ferroptosis (2) FGFR (1) FLT3 (2) Fluorescent Dye (5) Free Fatty Acid Receptor (2) Fungal (14) FXR (1) G Protein-coupled Receptor Kinase (GRK) (1) GABA Receptor (21) Galectin (1) GCGR (1) GHSR (7) GLP Receptor (1) Glucocorticoid Receptor (2) Glucokinase (3) GLUT (1) Glutaminase (3) Glutathione Peroxidase (1) Glutathione S-transferase (1) Glycosidase (4) GlyT (1) GnRH Receptor (8) GPR119 (1) GPR35 (1) GPR55 (2) GPR88 (2) GSK-3 (2) Guanylate Cyclase (2) HBV (3) HCN Channel (1) HCV (3) HCV Protease (1) HDAC (4) Heme Oxygenase (HO) (2) Herbicide (4) HIF/HIF Prolyl-Hydroxylase (3) Histamine Receptor (17) Histone Demethylase (1) HIV (5) HIV Integrase (1) HIV Protease (1) HMG-CoA Reductase (HMGCR) (1) HPV (1) HSV (1) iGluR (15) IKK (3) Influenza Virus (4) Insecticide (5) Insulin Receptor (2) Integrin (2) Interleukin Related (9) IRAK (3) IRE1 (1) Isotope-Labeled Compounds (17) JAK (1) JNK (1) Kallikrein (1) Keap1-Nrf2 (3) Ketohexokinase (1) LDLR (3) Leukotriene Receptor (1) Lipase (2) Lipoxygenase (2) LPL Receptor (3) mAChR (23) MAP4K (1) MEK (1) Melanocortin Receptor (5) Melatonin Receptor (1) mGluR (11) Microtubule/Tubulin (4) Mineralocorticoid Receptor (2) Mitochondrial Metabolism (2) Mitophagy (1) MMP (7) Monoamine Oxidase (11) Monoamine Transporter (2) Myosin (2) Na+/H+ Exchanger (NHE) (1) nAChR (12) Necroptosis (8) Neprilysin (5) Neurokinin Receptor (5) Neuropeptide FF Receptor (2) Neuropeptide Y Receptor (10) Neurotensin Receptor (1) NF-κB (10) NO Synthase (14) NOD-like Receptor (NLR) (1) Nucleoside Antimetabolite/Analog (4) Nucleoside Transporters (1) Opioid Receptor (12) Orexin Receptor (OX Receptor) (4) Oxytocin Receptor (5) P-glycoprotein (1) P2X Receptor (2) p38 MAPK (4) p62 (2) Parasite (17) PARP (4) PCSK9 (1) PD-1/PD-L1 (1) PDHK (1) PDK-1 (1) PERK (2) PGE synthase (1) Phosphodiesterase (PDE) (9) Phospholipase (2) Photosystem II (3) PI3K (5) PKC (5) Platelet-activating Factor Receptor (PAFR) (2) Potassium Channel (20) PPAR (5) Progesterone Receptor (1) Prolyl Endopeptidase (PREP) (3) Prostaglandin Receptor (13) PROTAC Linkers (2) PROTACs (1) Protease Activated Receptor (PAR) (1) PTHR (3) Raf (1) RAR/RXR (1) Reactive Oxygen Species (15) Renin (2) ROR (1) RSV (1) RXFP Receptor (1) SARS-CoV (4) Ser/Thr Protease (2) Serotonin Transporter (3) SHP2 (1) Sigma Receptor (9) Sirtuin (1) Small Interfering RNA (siRNA) (3) Sodium Channel (3) Somatostatin Receptor (3) SphK (1) Src (2) STAT (3) Stearoyl-CoA Desaturase (SCD) (1) Survivin (2) Tau Protein (2) TGF-beta/Smad (3) TGF-β Receptor (1) Thrombin (1) Thyroid Hormone Receptor (4) TNF Receptor (8) Toll-like Receptor (TLR) (5) Trace Amine-associated Receptor (TAAR) (1) Transmembrane Glycoprotein (1) TRP Channel (11) TrxR (1) Tryptophan Hydroxylase (1) TSH Receptor (2) Tyrosinase (3) Tyrosine Hydroxylase (1) Urotensin Receptor (4) Vasopressin Receptor (4) VD/VDR (1) VEGFR (2) Virus Protease (1) Wnt (1) Xanthine Oxidase (2) γ-secretase (2)
By Research Areas:	Cancer (109) Cardiovascular Disease (157) Endocrinology (46) Infection (67) Inflammation/Immunology (161) Metabolic Disease (164) Neurological Disease (344)
Click Chemistry:	Alkynes (4)
Oligonucleotides:	Release-retarding Agents (1) Solvents (1) CpG ODNs (2) Adjuvant (1) Sweetening Agents (1)

911

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

132

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-107322

Barnidipine hydrochloride Mepirodipine hydrochloride; YM-09730-5	Calcium Channel	Cardiovascular Disease
Barnidipine (Mepirodipine) hydrochloride is an L-type calcium antagonist (CaA) with high affinity for [ ³H] initrendipine binding sites (K_i = 0.21 nmol/L, has selective action against CaA receptors. Barnidipine hydrochloride is an orally active antihypertensive agent that can reduce the level of platelet-derived growth factor B-chain mRNA and peripheral vascular resistance .

HY-B1513

α-Cyclodextrin 2 Publications Verification	Microtubule/Tubulin SARS-CoV	Infection Metabolic Disease Cancer
α-Cyclodextrin (α-CD) is a soluble fiber derived from corn. α-Cyclodextrin can deplete sphingolipids and phospholipids from cell membranes. α-Cyclodextrin interacts with tubulin. α-Cyclodextrin improves defenses against SARS-CoV-2 infection. α-Cyclodextrin enhances the anticancer efficacy of Crcumin (HY-N0005) against breast, lung and cervical cancer. α-Cyclodextrin has beneficial effects on body weight and blood lipids .

HY-B0962

Piperidolate hydrochloride	mAChR	Neurological Disease
Piperidolate hydrochloride is an antimuscarinic, inhibits intestinal cramp induced by acetylcholine (rats and dogs).

HY-B0962A

Piperidolate	mAChR	Neurological Disease
Piperidolate is an antimuscarinic, inhibits intestinal cramp induced by acetylcholine (rats and dogs).

HY-167654

Treloxinate	Others	Cardiovascular Disease
Treloxinate is an effective hypolipidemic agent. Treloxinate affects only triglyceride levels in Sprague-Dawley rats, but affects both triglyceride and cholesterol levels in Wistar rats .

HY-126021

Mobam	Cholinesterase (ChE)	Neurological Disease
Mobam is a insecticide against Anoplura Pediculidae. Mobam inhibits cholinesterase (ChE) levels in rats plasma, erythrocytes, and brain, suppresses the avoidance behavior in rats .

HY-105294

FR 64822	Dopamine Receptor	Others
FR 64822 is a dopamine D2 receptor agonist that can induce antinociceptive activity in rats and mice by indirectly stimulating dopamine D2 receptors. FR 64822 can promote penile erection in juvenile rats and improve amnesia in rats induced by scopolamine during passive avoidance tasks .

HY-135238

(rel)-RSD 921 PD-117302	Opioid Receptor	Others
(rel)-RSD 921 (PD-117302) is a κ-opioid receptor agonist. (rel)-RSD 921 did not have a greater food-inducing effect in obese than in lean Zucker rats; in both obese and lean Zucker rats, lean rats were more sensitive to its initial food-inducing effect but ultimately ate less.

HY-120481

JNJ-40413269	FAAH	Neurological Disease
JNJ-40413269 is an inhibitor for FAAH, that inhibits human FAAH and rats FAAH with IC₅₀ of 28 nM and 270 nM. JNJ-40413269 exhibits analgesic efficacy in rat spinal nerve ligation model and exhibits good pharmacokinetic characteristics in rats .

HY-15402

Edonentan BMS 207940	Endothelin Receptor	Cardiovascular Disease
Edonentan (BMS 207940) is an antagonist for endothelin receptor (ET_A receptor), with a K_i of 10 pM. Edonentan is metabolic stable, exhibits good pharmakokinetic characters in rats. Edonentan regulates the endothelin system, blocks the big Endothelin-induced pressor response in rats model .

HY-N4209

3α-Dihydrocadambine	Others	Cardiovascular Disease
3α-Dihydrocadambine is a natural product isolated from the heartwoods of Anthocephalus cadamba.3α-Dihydrocadambine exhibits dose-dependent hypotensive and anti-hypertensive effects in anesthetized normotensive rats and in conscious spontaneously hypertensive rats .

HY-W096159

D-Biotinol	Endogenous Metabolite	Metabolic Disease
D-Biotinol is the nutrition of Lactobacillus arabinosus, L. casei, or Saccharomyces cerevisiae. D-Biotinol replaces the D-biotin (HY-B0511) in saving egg white induced biotin deficiency in rats. D-Biotinol is orally active and displays to be converted to biotin by rats .

HY-N1115

Tubotaiwine (+)-Tubotaiwine; NSC 306222; Tubotaiwin	Others	Cardiovascular Disease
Tubotaiwine ((+)-Tubotaiwine), an alkaloid, has beneficial effect on cadmium (Cd) induced hypertension in rats. Tubotaiwine regulates systolic, diastolic and mean arterial blood pressure of the Cd exposed rats. Tubotaiwine reduces arterial stiffness, inhibits of oxidative stress and increases vascular remodeling .

HY-101417R

Diethyl phosphate (Standard) Diethyl phosphoric acid (Standard)	Endogenous Metabolite Interleukin Related	Others
Diethyl phosphate (Standard) is the analytical standard of Diethyl phosphate. This product is intended for research and analytical applications. Diethylphosphate (Diethyl phosphoric acid) is an orally active organophosphorus pesticides metabolite. Diethylphosphate can interfere with thyroid hormone-related mechanisms and affect intestinal microbes in rats[1][2][3].

HY-111081

(±)-PPCC	Sigma Receptor	Neurological Disease
(±)-PPCC is a sigma-1 agonist that mainly interacts with sigma-1 receptors with K_i of 1.5 nM. (±)-PPCC has effective anti-amnesia effects in rats with mild or severe cognitive impairment, and can improve the cognitive abilities of rats .

HY-107482

Picamilon Nicotinoyl-GABA; Nicotinoyl-γ-aminobutyric acid	GABA Receptor	Neurological Disease
Picamilon is an orally active derivative of γ-aminobutyric acid that has nootropic effect. Picamilon improves the epilepsy model in rats and promotes correction of functional disorders of the pancreas during Alloxan (HY-W017227)-induced diabetes mellitus in rats .

HY-B1978

Iprodione	Fungal Reactive Oxygen Species Androgen Receptor	Infection
Iprodione is an orally active diformimide fungicide. Iprodione can specifically cause oxidative damage by producing free radicals (ROS). Iprodione is also an antiandrogen agent that delays adolescent development in rats and reduces sexual behavior and reproductive ability in rats .

HY-107482A

Picamilon sodium Nicotinoyl-GABA sodium; Nicotinoyl-γ-aminobutyric acid sodium; Sodium 4-(nicotinamido)butanoate	GABA Receptor	Neurological Disease
Picamilon sodium is an orally active derivative of γ-aminobutyric acid that has nootropic effect. Picamilon sodium improves the epilepsy model in rats and promotes correction of functional disorders of the pancreas during Alloxan (HY-W017227)-induced diabetes mellitus in rats .

HY-121528

Nilestriol Nylestriol; EE3CPE	Estrogen Receptor/ERR	Endocrinology
Nilestriol is a estriol derivative, which inhibits osteoporosis on ovariectomized rats or postmenopausal women .

HY-W011873

Palmitoleic acid 5+ Cited Publications	Endogenous Metabolite	Neurological Disease
Palmitoleic acid, a composition of fatty acid, is implicated in the prevention of death from cerebrovascular disorders in SHRSP rats.

HY-W011873A

Palmitoleic acid sodium C16:1(9Z); C16:1 n-7; (9Z)-Hexadecenoic acid	Endogenous Metabolite	Neurological Disease
Palmitoleic acid sodium, a composition of fatty acid, is implicated in the prevention of death from cerebrovascular disorders in SHRSP rats.

HY-135761S

Penconazole-d7	Fungal Cholinesterase (ChE)	Infection
Penconazole-d₇ is the deuterium labeled Penconazole[1]. Penconazole is a typical triazole fungicide, and mainly applied on apples, grapes, and vegetables to control powdery mildew. Penconazole inhibits sterol biosynthesis in fungi. Penconazole decrease AChE activity in the cerebrum and cerebellum of rats[2][3].

HY-111081C

(±)-PPCC oxalate	Sigma Receptor	Neurological Disease
(±)-PPCC oxalate is a sigma-1 agonist that mainly interacts with sigma-1 receptors with K_i of 1.5 nM. (±)-PPCC oxalate has effective anti-amnesia effects in rats with mild or severe cognitive impairment, and can improve the cognitive abilities of rats .

HY-12586

AZD6564	Thrombin	Others
AZD6564 is an orally active inhibitor for fibrinolysis through disruption of plasma kinase-fibrin interaction. AZD6564 dissolves human plasma clot with an IC₅₀ of 0.44 μM. AZD6564 ameliorates hemorrhage in rats with EC₅₀ of 1.62 μM, and exhibits good pharmacokinetic characteristics in rats .

HY-P0037

Org-30850 Org 30850ANT	Others GnRH Receptor	Endocrinology
Org-30850 is a potent LHRH antagonist designed for treating hormone-dependent disorders. In animal studies, a single subcutaneous dose effectively inhibited ovulation in rats and significantly reduced testosterone levels in male rats for up to 48 hours post-administration. Daily doses of Org-30850 in female rats suppressed estrous cycles, decreased uterine and ovarian weights, and lowered estradiol and FSH serum levels. In male rats, prolonged treatment resulted in reversible reductions in gonadal function and testosterone levels, with almost complete recovery observed after cessation of treatment. Unlike comparable LHRH antagonists, Org-30850 exhibited minimal injection site irritation and no edematous reactions, suggesting a more favorable therapeutic profile .

HY-N11503

Disialyllacto-N-tetraose	Others	Inflammation/Immunology
Disialyllacto-N-tetraose is a human milk oligosaccharide that prevents necrotising enterocolitis in neonatal rats .

HY-105637

Cropropamide Propylbutamide	Drug Intermediate	Neurological Disease
Cropropamide is a component of the respiratory stimulant Prethamide. Cropropamide increases locomotor activity in rats .

HY-19005

GYKI-32887	Dopamine Receptor	Neurological Disease
GYKI-32887 is a dopaminergic agonist that can reduce the motor activity levels in rats .

HY-W013113

BTMPS	nAChR	Neurological Disease
BTMPS is a nicotine receptor (nAChR) antagonist that can lessen the negative effects of morphine on rats .

HY-100189

LS2265	PPAR Cytochrome P450 Autophagy	Metabolic Disease
LS2265 is a taurine derivative of fenofibrate and can induce proliferation of peroxisomes in liver cells of rats.

HY-119602

Rolziracetam CI-911	Others	Neurological Disease
Rolziracetam is a nootropic agent of the racetam family and improves short-term memory in rats and monkeys .

HY-107652

AF-DX 384	mAChR	Neurological Disease
AF-DX 384 is a selective antagonist of M2 and M4 muscarinic acetylcholine receptors (K_is=6.03 and 10 nM, respectively) . AF-DX 384 reverses deficits in novel object recognition and passive avoidance in aged rats, as well as in young rats with impairments induced by scopolamine .

HY-B0476S

Phenacetin-d5 Acetophenetidin-d₅	COX	Inflammation/Immunology
Phenacetin-d₅ is the deuterium labeled Phenacetin. Phenacetin (Acetophenetidin) is a non-opioid analgesic/antipyretic agent. Phenacetin is a selective COX-3 inhibitor. Phenacetin is used as probe of cytochrome P450 enzymes CYP1A2 in human liver microsomes and in rats[1][2][3].

HY-121550

ME3221	Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease
ME3221 is an angiotensin AT1 receptor antagonist that effectively antagonizes the pressor response to angiotensin II in rats and marmosets without affecting the hypotensive response to bradykinin. It demonstrates potent antihypertensive effects in renal hypertensive rats and spontaneously hypertensive rats (SHR), with efficacy comparable to or better than losartan in vivo. ME3221's repeated administration in SHR results in sustained and stable hypotensive effects without affecting heart rate, indicating its potential for treating both renal and essential hypertension similarly to losartan .

HY-117038

Anordiol	Estrogen Receptor/ERR	Endocrinology
Anordiol is an antiestrogenic compound with weak estrogenic activity. It can reduce the parameters of uterine growth (including uterine wet weight, soluble protein content, and DNA content) induced by estradiol in rats and can also regulate the estrous cycle in rats. Anordiol holds potential application value in the research of antiestrogen-related diseases .

HY-123904

UoS12258	iGluR	Neurological Disease
UoS12258 is a selective positive allosteric modulator of AMPA receptor. UoS12258 enhances AMPA receptor‐mediated synaptic transmission. UoS12258 improves performance in cognition rat models, including Scopolamine (HY-N0296)‐impaired rats and water maze learning and retention in aged rats .

HY-105454R

Recainam (Standard) Wy-42362 (Standard)	Others	Cardiovascular Disease
Recainam (Standard) is the analytical standard of Recainam. This product is intended for research and analytical applications. Recainam (Wy-42362) is an orally active anti-arrhythmic agent with Class I electrophysiological properties. Recainam suppresses complex ventricular arrhythmias. Racainam exhibits a good pharmacokinetic character in Sprague Dawley rats[1][2].

HY-145713

GS-8873 HBV-IN-19	HBV	Infection
GS-8873 is an orally active inhibitor for the production of hepatitis B virus (HBV) surface antigen (HBsAg) with an EC₅₀ of 4 nM. GS-8873 exhibits good pharmacokinetic characters in rats and metabolic stability in human hepatocytes. GS-8873 causes neurofunctional deficits in rats and cynomolgus monkeys .

HY-129208

Viridicatumtoxin	Antibiotic Fungal	Infection
Viridicatumtoxin is a new mycotoxin extracted from Penicillium viridicatum with a LD₅₀ of 122.4 mg/kg in rats.

HY-105495

Iliparcil	Others	Cardiovascular Disease
Iliparcil has a potent antithrombotic activity in the Wessler model in rats. Iliparcil has oral activity .

HY-114914

3-Hydroxylidocaine	Endogenous Metabolite	Cardiovascular Disease
3-Hydroxylidocaine is the major metabolite of Lidocaine (HY-B0185) in rats and sheep .

HY-106300

AA 193	Others	Cardiovascular Disease
AA 193 is a uricosuric agent. AA 193 increases urate excretion in hyperuricemic rats .

HY-124223

AF-DX 384 methanesulfonate	mAChR	Neurological Disease
AF-DX 384 (methanesulfonate) is a selective antagonist of M2 and M4 muscarinic acetylcholine receptors (K_is=6.03 and 10 nM, respectively) . AF-DX 384 (methanesulfonate) reverses deficits in novel object recognition and passive avoidance in aged rats, as well as in young rats with impairments induced by scopolamine .

HY-B0476S1

Phenacetin-13C	COX	Inflammation/Immunology
Phenacetin- ¹³C is the ¹³C labeled Phenacetin[1]. Phenacetin (Acetophenetidin) is a non-opioid analgesic/antipyretic agent. Phenacetin is a selective COX-3 inhibitor. Phenacetin is used as probe of cytochrome P450 enzymes CYP1A2 in human liver microsomes and in rats[2][3][4].

HY-121796

Mixanpril	Neprilysin	Others
Mixanpril is a compound with the ability to modulate insulin sensitivity and has the activity of regulating insulin sensitivity and femoral blood flow in obese Zucker rats. Mixanpril can affect insulin-mediated glucose disposal in obese Zucker rats and also has a regulatory effect on femoral blood flow, with different effects compared to the ACE inhibitor captopril.

HY-135222

MMAI hydrochloride 5-Methoxy-6-methyl-2-aminoindan hydrochloride	5-HT Receptor	Neurological Disease
MMAI (5-Methoxy-6-methyl-2-aminoindan) hydrochloride is a selective serotonin releaser that does not produce psychoactive or hallucinogenic effects in the context of drug discrimination in rats. MMAI hydrochloride induces a behavioral syndrome in rats, including hypokinesia with freezing, spinning, Straub tail, flat posture, and reduced sleep time .

HY-118683

KR-31378	Potassium Channel	Others
KR-31378 is a neuroprotectant with dose-dependent pharmacokinetic properties and relevant activity in rats. After intravenous and oral administration of KR-31378 in rats, its pharmacokinetic parameters showed dose-dependent changes, such as decreased clearance with increasing doses, good oral absorption, and comparable AUCs for intravenous and oral administration at different doses.

HY-118821

JTC-017	CRFR	Metabolic Disease
JTC-017, a specific corticotropin-releasing hormone receptor 1 antagonist, attenuates hippocampal noradrenaline release, visceral perception, adrenocorticotropic hormone release, and anxiety after acute colorectal distention in rats. JTC-017 blocks stress-induced changes in colonic motility after chronic colorectal distention in rats .

HY-129485

CM304	Sigma Receptor	Neurological Disease
CM304 is a potent S1R inhibitor that can inhibit drug-induced convulsions in rats .

HY-10655AR

Palosuran hydrochloride (Standard) ACT-058362 hydrochloride (Standard)	Urotensin Receptor	Cardiovascular Disease
Palosuran (hydrochloride) (Standard) is the analytical standard of Palosuran (hydrochloride). This product is intended for research and analytical applications. Palosuran hydrochloride (ACT-058362 hydrochloride) is a potent, selective, and orally active antagonist of urotensin II receptor, with an IC50 of 3.6 nM for CHO cell membranes expressing human recombinant receptors. Palosuran hydrochloride can improves pancreatic and renal function in diabetic rats[1][2].

Cat. No.	Product Name	Type

HY-B0377G

Famotidine (GMP) MK-208 (GMP)	Fluorescent Dye
Famotidine GMP (MK-208 GMP) is Famotidine (HY-B0377) produced in GMP guideline. Famotidine GMP is a competitive histamine H2-receptor antagonist, inhibits gastric secretion, activates the gastric mucosal defensive mechanisms. Famotidine GMP ameliorates peptic ulcer disease (PUD) and gastroesophageal reflux disease (GERD/GORD) in rats model .

HY-107614G

1-Oleoyl lysophosphatidic acid (sodium) (GMP)

1-Oleoyl-sn-glycero-3-phosphate (sodium) (GMP); 1-Oleoyl-LPA (sodium) (GMP)

Fluorescent Dye

1-Oleoyl lysophosphatidic acid sodium (GMP) is a GMP-grade 1-Oleoyl lysophosphatidic acid sodium that can be used as an auxiliary reagent in cell therapy. 1-Oleoyl lysophosphatidic acid sodium can stimulate neuronal differentiation in neural progenitor cells from mice or rats, and it also promotes the differentiation of human adipose-derived mesenchymal stem cells into myofibroblast-like cells in vitro by activating the autocrine TGF-β1-Smad signaling pathway .

Cat. No.	Product Name	Type

HY-D1005A22

Poloxamer 338 (F108) PEG-PPG-PEG, 14600 (Average)	Co-solvents
Poloxamer 338 F108 is block polymer of polyoxyethylene and polyoxypropylene with average molecular mass of 14600. Poloxamer 338 F108 reduces the aggregation of red blood cells, inhibits proliferation of human lymphocyte cell IIBR1. Poloxamer 338 F108 exhibits short-term and subchronic toxicity in rats .

HY-N0157C

Orotic acid potassium

2 Publications Verification

6-Carboxyuracil potassium; Vitamin B13 potassium

Cell Assay Reagents

Orotic acid potassium (Vitamin B13 potassium) is a precursor of pyrimidine bases and is involved in the synthesis of DNA and RNA. Orotic acid potassium stimulates the growth of animals, plants and microorganisms, participates in carbohydrate metabolism, and is necessary for the growth and life activities of organisms. Orotic acid potassium is a measurement indicator in routine newborn screening for urea cycle abnormalities. Orotic acid potassium can cause hepatic steatosis and hepatomegaly in rats .

HY-Y1275

N-Methylpyrrolidone NMP; 1-Methyl-2-pyrrolidinone	Co-solvents
N-Methylpyrrolidone (1-Methyl-2-pyrrolidinone), a five-membered cyclic amide, is an orally active organic polar solvent with teratogenicity and toxicity. N-Methylpyrrolidone is low in acute toxicity with a LD₅₀ value of 3914 mg/kg in rats and of 4050 mg/kg in mice. N-Methylpyrrolidone is extensively used in the manufacture of adhesives, paints, fuels, and pharmaceuticals .

HY-D1005A6

Poloxamer 124 (L44)

PEG-PPG-PEG, 2200 (Averag)

Co-solvents

Poloxamer 124 L44 is block polymer of polyoxyethylene and polyoxypropylene with average molecular mass of 2200. Poloxamer 124 L44 reveals toxicity with an oral LD₅₀ of 5 g/kg in albino rats. Poloxamer 124 L44 causes ocular irritation. Poloxamer 124 L44 forms thermoreversible hydrogel, that is utilized in food additives, drug delivery carriers in cosmetics, pharmaceutical ingredients and tissue engineering .

HY-W127391

1,2-Dilaurin

(Rac)-1,2-Didodecanoylglycerol

Drug Delivery

1,2-Dilaurin is a diacylglycerol containing lauric acid at the sn-1 and sn-2 positions. It has been used as an internal standard for the quantification of diglycerides in rat desheathed sciatic nerves. [1] Monomolecular films containing 1,2-dilauroyl-rac-glycerol have been used as substrates to measure surface pressure and the effect of pancreatic procolipase and colipase on porcine pancreatic lipase activity. [2] References: [1]. Zhu, X. and Eichberg, J. 1,2-Diacylglycerol content and its arachidonyl-containing molecular species are reduced in the sciatic nerve of streptozotocin-induced diabetic rats. J. Neurochemistry. 55(3), 1087-1090 (1990).[2]. Wieloch, T., Borgstr m, B., Piéroni, G. et al. Porcine trypsinogen and its trypsin-activated form: lipid binding and lipase activation on monomolecular membranes. FEBS Express. 128(2), 217-220 (1981).

HY-W203728

L-β-Imidazolelactic acid	Microbial Culture
L-β-Imidazolelactic acid is a histidine derivative and an oxidizing agent that can trigger antioxidant effects in the brain cortex of rats .

HY-D1005A16

Poloxamer 235 (P85) PEG-PPG-PEG, 4600 (Averag)	Co-solvents
Poloxamer 235 P85 is block polymer of polyoxyethylene and polyoxypropylene with average molecular mass of 4600. Poloxamer 235 P85 exhibits acute and subchronic toxicity in albino rats with an oral LD₅₀ of >34.6 g/kg. Poloxamer 235 P85 induces ocular irritation in rabbits .

HY-B0377G

Famotidine (GMP) MK-208 (GMP)	Biochemical Assay Reagents
Famotidine GMP (MK-208 GMP) is Famotidine (HY-B0377) produced in GMP guideline. Famotidine GMP is a competitive histamine H2-receptor antagonist, inhibits gastric secretion, activates the gastric mucosal defensive mechanisms. Famotidine GMP ameliorates peptic ulcer disease (PUD) and gastroesophageal reflux disease (GERD/GORD) in rats model .

HY-107614G

1-Oleoyl lysophosphatidic acid (sodium) (GMP)

1-Oleoyl-sn-glycero-3-phosphate (sodium) (GMP); 1-Oleoyl-LPA (sodium) (GMP)

Biochemical Assay Reagents

HY-W342458

Betamethasone 17-Propionate

Cell Assay Reagents

Betamethasone 17-Propionate is a compound used to study its effects on endotoxin-induced uveitis in rats. It has the activity of inhibiting the infiltration of cells into the aqueous humor in endotoxin-induced uveitis by eye drops and systemic administration at a certain dose. However, its inhibitory effect is relatively weak compared with some other compounds. At the same time, the dose for systemic administration is 1mg/kg. In addition, Betamethasone 17-Propionate has a weaker inhibitory effect on the release of IL-8 from rat peritoneal exudate cells in an in vitro interleukin-8 (IL-8) release assay than betamethasone. Moreover, the simultaneous addition of betamethasone dipropionate and betamethasone 17-Propionate reduces the inhibitory effect of betamethasone on cell infiltration and IL-1β gene expression.

Cat. No.	Product Name	Target	Research Area

HY-145633

Sozinibercept OPT 302; VGX-300	VEGFR	Cardiovascular Disease
Sozinibercept (OPT 302; VGX-300) is a soluble form of VEGFR-3, potently inhibits the activity of VEGF-C/D, which are the proangiogenic factors, inhibiting angiogenesis and vascular leakage. Sozinibercept also inhibits diabetic retinal edema in rats .

HY-P990093

Stapokibart CM310	Interleukin Related	Inflammation/Immunology
Stapokibart (CM310) is a humanised monoclonal antibody targeting IL-4Rα and efficiently blocks the interaction of cytokines IL-4 and IL-13 with their co-receptor subunit IL-4Rα. Stapokibart has the capacity to interact with IL-4Rα in humans, cynomolgus monkeys, and rats .

HY-P990679

Rat IgG2a kappa, Isotype Control	Inhibitory Antibodies	Others Cancer
Rat IgG2a kappa, Isotype Control is a monoclonal antibody derived from rats, representing the immunoglobulin G2a (IgG2a) subclass with a kappa light chain. Rat IgG2a kappa, Isotype Control exhibits high efficiency in inducing K cell mediated cytotoxicity. Rat IgG2a kappa, Isotype Control is utilized in research investigating the roles of different immunoglobulin subclasses in tumor immunology .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B1513

α-Cyclodextrin 2 Publications Verification	Structural Classification Zea mays L. Polysaccharides Classification of Application Fields Gramineae Source classification Other Diseases Plants Disease Research Fields Saccharides	Microtubule/Tubulin SARS-CoV
α-Cyclodextrin (α-CD) is a soluble fiber derived from corn. α-Cyclodextrin can deplete sphingolipids and phospholipids from cell membranes. α-Cyclodextrin interacts with tubulin. α-Cyclodextrin improves defenses against SARS-CoV-2 infection. α-Cyclodextrin enhances the anticancer efficacy of Crcumin (HY-N0005) against breast, lung and cervical cancer. α-Cyclodextrin has beneficial effects on body weight and blood lipids .

HY-W096159

D-Biotinol	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
D-Biotinol is the nutrition of Lactobacillus arabinosus, L. casei, or Saccharomyces cerevisiae. D-Biotinol replaces the D-biotin (HY-B0511) in saving egg white induced biotin deficiency in rats. D-Biotinol is orally active and displays to be converted to biotin by rats .

HY-W011873

Palmitoleic acid 5+ Cited Publications	Structural Classification Human Gut Microbiota Metabolites Microorganisms Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Endogenous Metabolite
Palmitoleic acid, a composition of fatty acid, is implicated in the prevention of death from cerebrovascular disorders in SHRSP rats.

HY-N11503

Disialyllacto-N-tetraose	Structural Classification Polysaccharides Source classification Endogenous metabolite Saccharides	Others
Disialyllacto-N-tetraose is a human milk oligosaccharide that prevents necrotising enterocolitis in neonatal rats .

HY-N4209

3α-Dihydrocadambine	Uncaria tomentosa (Willd. ex Schult.) DC. Structural Classification Alkaloids Other Alkaloids Source classification Rubiaceae Plants	Others
3α-Dihydrocadambine is a natural product isolated from the heartwoods of Anthocephalus cadamba.3α-Dihydrocadambine exhibits dose-dependent hypotensive and anti-hypertensive effects in anesthetized normotensive rats and in conscious spontaneously hypertensive rats .

HY-N1115

Tubotaiwine (+)-Tubotaiwine; NSC 306222; Tubotaiwin	Apocynaceae Structural Classification Alkaloids Other Alkaloids Source classification Hunteria zeylanica Plants	Others
Tubotaiwine ((+)-Tubotaiwine), an alkaloid, has beneficial effect on cadmium (Cd) induced hypertension in rats. Tubotaiwine regulates systolic, diastolic and mean arterial blood pressure of the Cd exposed rats. Tubotaiwine reduces arterial stiffness, inhibits of oxidative stress and increases vascular remodeling .

HY-101417R

Diethyl phosphate (Standard) Diethyl phosphoric acid (Standard)	Structural Classification Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Endogenous Metabolite Interleukin Related
Diethyl phosphate (Standard) is the analytical standard of Diethyl phosphate. This product is intended for research and analytical applications. Diethylphosphate (Diethyl phosphoric acid) is an orally active organophosphorus pesticides metabolite. Diethylphosphate can interfere with thyroid hormone-related mechanisms and affect intestinal microbes in rats[1][2][3].

HY-N13127

Segetalin C	Structural Classification Natural Products Source classification Plants Vaccaria hispanica Caryophyllaceae	Others
Segetalin C is a cyclic peptide that increases uterine weight in ovariectomized rats (2.5 mg/kg).

HY-129208

Viridicatumtoxin	Other Terpenoids Infection Microorganisms Classification of Application Fields Terpenoids Source classification Disease Research Fields	Antibiotic Fungal
Viridicatumtoxin is a new mycotoxin extracted from Penicillium viridicatum with a LD₅₀ of 122.4 mg/kg in rats.

HY-N9226

Glucocheirolin	Structural Classification Source classification Glucosinolates Plants Brassicaceae	Others
Glucocheirolin, a natural compound that can be isolated from Erysimum corinthium Boiss, possesses antinutritional and toxic effects in rats .

HY-N0300

Tetrahydropalmatine 2 Publications Verification DL-Tetrahydropalmatine	Alkaloids Structural Classification Corydalis yanhusuo W. T. Wang Source classification Plants Isoquinoline Alkaloids Papaveraceae	Dopamine Receptor Apoptosis
Tetrahydropalmatine possesses analgesic effects. Tetrahydropalmatine acts through inhibition of amygdaloid release of dopamine to inhibit an epileptic attack in rats .

HY-N15336

Tschimganin	Ferula tschimganica Lipsky ex Korovin Structural Classification Monophenols Source classification Phenols Umbelliferae Plants	Estrogen Receptor/ERR
Tschimganin is an ester of terpenoid acids with estrogen activity, which is found in F. tschimganica. Tschimganin can increase the growth of uterus of immature rats .

HY-N0300A

Tetrahydropalmatine hydrochloride 2 Publications Verification DL-Tetrahydropalmatine hydrochloride	Alkaloids Structural Classification Corydalis yanhusuo W. T. Wang Source classification Plants Isoquinoline Alkaloids Papaveraceae	Dopamine Receptor
Tetrahydropalmatine (DL-Tetrahydropalmatine) hydrochloride possesses analgesic effects. Tetrahydropalmatine hydrochloride acts through inhibition of amygdaloid release of dopamine to inhibit an epileptic attack in rats .

HY-N11449

Nardoaristolone B	Structural Classification Terpenoids Sesquiterpenes Source classification Nardostachys jatamansi (D. Don) DC. Plants Valerianaceae	Others
Nardoaristolone B, a non-sesquiterpene compound isolated from the root of Nardostachys jatamansi, has protective effects on cardiomyocyte injury in neonatal rats .

HY-N7981

Pratensein	Structural Classification Trifolium pratense L. Flavonoids Leguminosae Source classification Phenols Polyphenols Plants Isoflavones	NF-κB
Pratensein, a flavonoid, ameliorates β-amyloid-induced cognitive impairment in rats via reducing oxidative damage and restoring synapse and BDNF levels .

HY-126848

Diclofenac acyl glucuronide D-1-O-G	Structural Classification Alkaloids Classification of Application Fields Other Alkaloids Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	Drug Metabolite Endogenous Metabolite
Diclofenac acyl glucuronide (D-1-O-G) is a major bile metabolite directly involved in small intestinal ulceration in rats .

HY-N11948

Simmondsin	Structural Classification Polysaccharides Source classification Plants Simmondsia chinensis (Link) C. K. Schneid. Saccharides Simmondsiaceae	Reactive Oxygen Species Endogenous Metabolite
Simmondsin, derived from the jojoba plant (Simmondsia chinensis), has been shown to decrease food intake and body weight in rats without any noticeable adverse effects.

HY-P1742

Gluten Exorphin B5	Natural Products Monophenols Classification of Application Fields Source classification Agrostidoideae Phenols Metabolic Disease Plants Disease Research Fields Triticum aestivum L.	Opioid Receptor
Gluten Exorphin B5 is an exogenous opioid peptides derived from wheat gluten, acts on opioid receptor, increases postprandial plasma insulin level in rats .

HY-101417

Diethyl phosphate Diethyl phosphoric acid	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite Interleukin Related
Diethylphosphate (Diethyl phosphoric acid) is an orally active organophosphorus pesticides metabolite. Diethylphosphate can interfere with thyroid hormone-related mechanisms and affect intestinal microbes in rats .

HY-N9483

7-Keto-DHEA 7-Oxo-DHEA; 7-Ketodehydroepiandrosterone; 7-Oxodehydroepiandrosterone	Structural Classification Source classification Endogenous metabolite Steroids	GABA Receptor
7-Keto-DHEA binds to GABA Receptor, and reduces the ethanol intake in rats. 7-Keto-DHEA exhibits potential in investigation of alcohol dependence disorders .

HY-W751152

α,β-Thujone	Structural Classification Terpenoids Source classification Artemisia austriaca Jacq. Plants Compositae	GABA Receptor
α,β-Thujone is a component of the essential oils of some plants. α,β-Thujone causes cancers in male rats and induces seizures in the highest doses .

HY-B0940

Ethylvanillin	Microorganisms Source classification	Cytochrome P450
Ethylvanillin is an orally active antioxidant that can affect cytochrome P450 activity in rats. It can also be used as a food flavoring agent in the field of food processing .

HY-N14226

Eurystatin B	Structural Classification Microorganisms Antibiotics Source classification Beta-lactam Antibiotics	Prolyl Endopeptidase (PREP)
Eurystatin B is a prolyl endopeptidase (PED) inhibitor. Eurystatin B has a protective effect during Scopolamine (HY-N0296)-induced amnesia in rats .

HY-N8931

Monomethyl lithospermate Lithospermic acid monomethyl ester	Structural Classification Labiatae Source classification Samanea saman (Jacq.) Merr. Phenols Polyphenols Plants	Akt
Monomethyl lithospermate activates the PI3K/AKT pathway, which plays a protective role in nerve injury. Monomethyl lithospermate can improve the survival ability of SHSY-5Y cells, inhibit the breakdown of mitochondrial membrane potential (MMOP) and inhibit cell apoptosis. Monomethyl lithospermate also reduced the level of oxidative stress in the brain tissue of rats with middle artery occlusion (MCAO) and improved nerve damage in rats with ischemic stroke (IS) .

HY-N9363

Corymbiferin	Structural Classification other families Xanthones Classification of Application Fields Source classification Phenols Polyphenols Metabolic Disease Plants Disease Research Fields	Others
Corymbiferin is one of active constituents, responsible for anti-diabetic properties. Corymbiferin improves antioxidant capacity and carbohydrate metabolism in diabetic rats, along with the improvement of histopathology of livers and pancreatic β cells .

HY-118383

Agathisflavone	Structural Classification Flavonoids Flavones Source classification Araucariaceae Agathis robusta (C. Moore ex F. Muell.) F. M. Bailey Plants	Parasite
Agathisflavone is a flavonoid with antioxidant, anti-inflammatory, antiviral, antiparasitic, cytotoxic, neuroprotective, and hepatoprotective activities. Agathisflavone can improve tissue repair in a spinal cord injury model in rats .

HY-127152

Hippadine Pratorine	Structural Classification Natural Products Crinum bulbispermum (Burm.f.) Milne-Redh. & Schweick. Source classification Plants Amaryllidaceae	Endogenous Metabolite
Hippadine (Pratorine) is an alkaloid, which can be isolated from the plant Crinum macowanii. Hippadine exhibits heart-rate lowering and blood-pressure lowering effects in rats models with spontaneously hypertensive .

HY-121401A

(−)-Myrtenal (1R)-(−)-Myrtenal; (−)-(1R,5S)-Myrtenal	Structural Classification Other Monoterpenes Classification of Application Fields Terpenoids Labiatae Source classification Erythrina poeppigiana Metabolic Disease Plants Disease Research Fields	Akt
(-)-Myrtenal ((1R)-(-)-Myrtenal) is an orally active terpene with antitumour activity. (-)-Myrtenal ameliorates hyperglycemia by enhancing GLUT2 through Akt in the skeletal muscle and liver of diabetic rats .

HY-N6910

Pseudolaric Acid C2	other families Classification of Application Fields Terpenoids Source classification Metabolic Disease Diterpenoids Plants Disease Research Fields	Others
Pseudolaric Acid C2, a diterpenoid isolated from Pseudolarix kaempferi, is identified as the specific metabolite of Pseudolaric acid B in plasma, urine, bile and feces after both oral and intravenous administration to rats .

HY-N0300R

Tetrahydropalmatine (Standard)	Alkaloids Structural Classification Corydalis yanhusuo W. T. Wang Source classification Plants Isoquinoline Alkaloids Papaveraceae	Dopamine Receptor Apoptosis
Tetrahydropalmatine (Standard) is the analytical standard of Tetrahydropalmatine. This product is intended for research and analytical applications. Tetrahydropalmatine possesses analgesic effects. Tetrahydropalmatine acts through inhibition of amygdaloid release of dopamine to inhibit an epileptic attack in rats .

HY-107248

Escin IIa	Triterpenes Structural Classification other families Classification of Application Fields Terpenoids Hippocastanaceae Source classification Aesculus hippocastanum Plants Inflammation/Immunology Disease Research Fields	Others
Escin IIa, isolated from horse chestnut, the seeds of Aesculus hippocastanum L., has positive effects on acute inflammation in animals. Escin IIa has gastroprotections on ethanol-induced gastric mucosal lesions in rats .

HY-127166

Colchiceine O10-Demethylcolchicine	Colchicaceae Structural Classification Alkaloids Other Alkaloids Source classification Plants Colchicum autumnale L.	Microtubule/Tubulin
Colchiceine is one of several metabolites of the anti-gout medication Colchicine (HY-16569). Colchicine is a tubulin inhibitor and a microtubule disrupting agent, and may protect rats from developing liver injury and fibrosis .

HY-N0723

Neomangiferin	Structural Classification Liliaceae Xanthones Classification of Application Fields Source classification Phenols Polyphenols Metabolic Disease Anemarrhena asphodeloides Bunge Plants Disease Research Fields	Others
Neomangiferin is a natural C-glucosyl xanthone isolated from m the dried rhizome of Anemarrhena asphodeloides. Neomangiferin has significant therapeutic effects on high-fat diet-induced nonalcoholic fatty liver disease (NAFLD) in rats .

HY-N2531

Notoginsenoside Fc	Cardiovascular Disease Triterpenes Structural Classification Panax notoginseng (Burkill) F. H. Chen ex C. H. Chow Classification of Application Fields Terpenoids Source classification Plants Disease Research Fields Araliaceae	Autophagy
Notoginsenoside Fc, a protopanaxadiol- (PPD-) type saponin isolated from the leaves of Panax notoginseng, effectively counteracts platelet aggregation. Notoginsenoside Fc can accelerate reendothelialization following vascular injury in diabetic rats by promoting autophagy .

HY-75087

(R)-pyrrolidine-2-carboxylic acid (+)-(R)-Proline; (R)-(+)-Proline; (R)-2-Carboxypyrrolidine; (R)-Proline	Structural Classification Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
(R)-pyrrolidine-2-carboxylic acid ((+)-(R)-Proline) is a proline isomer that exhibits high renal and hepatotoxicity in rats. (R)-pyrrolidine-2-carboxylic acid can be used to study amino acid metabolism and toxicity mechanisms .

HY-N0691

Schisandrin 3 Publications Verification Schizandrin; Schizandrol; Schizandrol-A	Structural Classification Classification of Application Fields Source classification Lignans Phenylpropanoids Plants Schisandraceae Schisandra chinensis (Turcz.) Baill. Disease Research Fields Cancer	Autophagy
Schisandrin (Schizandrin), a dibenzocyclooctadiene lignan, is isolated from the fruit of Schisandra chinensis Baill. Schisandrin exhibits antioxidant, hepatoprotective, anti-cancer and anti-inflammatory activities. Schisandrin also can reverses memory impairment in rats .

HY-N2196

Ajugasterone C	Structural Classification Classification of Application Fields Ranunculaceae Source classification Plants Inflammation/Immunology Disease Research Fields Pulsatilla chinensis (Bunge) Regel Steroids	Others
Ajugasterone C is an ecdysteroid isolated from Leuzea carthamoides. Ajugasterone C shows significant inhibitory effect at 100 mg/kg dose on rat paw oedema development due to Carrageenan-induced inflammation in Sprague Dawley rats .

HY-16197

Epicochlioquinone A	Structural Classification Natural Products Microorganisms Source classification	Acyltransferase
Epicochlioquinone A can inhibit rat liver microsomal ACAT with IC₅₀ of 1.7 μM, inhibit plasma lecithin cholesterol acyltransferase (LCAT) with IC₅₀ of 15.8 μM, and inhibit cholesterol absorption in rats by 50% at 75 mg/kg .

HY-N9113

1,3,5,6-Tetrahydroxyxanthone	Flavonoids Source classification Guttiferae Hyperlcurn perforatum L. Plants Other Flavonoids	Others
1,3,5,6-Tetrahydroxyxanthone is a natural xanthone that can be isolated from Garcinia achachairu Rusby (Clusiaceae) branches. 1,3,5,6-Tetrahydroxyxanthone induces diuresis and saluresis in normotensive and hypertensive rats .

HY-W012946

2-Furoic acid Pyromucic acid	Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	ATP Citrate Lyase Acyltransferase Endogenous Metabolite
2-Furoic acid (Furan-2-carboxylic acid) is an organic compound produced through furfural oxidation . 2-Furoic acid exhibits hypolipidemic effet, lowers both serum cholesterol and serum triglyceride levels in rats .

HY-N10226

Thielavin B	Cardiovascular Disease Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Phenols Polyphenols Disease Research Fields	Prostaglandin Receptor
Thielavin B is an inhibitor of prostaglandin biosynthesis produced by Thielavia terricola. Thielavin B effectively influences the prostaglandin E2 synthesis from the endoperoxide. Thielavin B is significantly effective on carrageenan-induced oedema of rats when administered intravenously .

HY-N4009

Iriflophenone 2-O-α-rhamnoside	Structural Classification Thymelaeaceae Source classification Phenols Polyphenols Plants Aquilaria sinensis (Lour.) Spreng.	Others
Iriflophenone 2-O-α-rhamnoside can be isolated from the leaves of Aquilaria sinensis. Iriflophenone 2-O-α-rhamnoside has a half-life value of 2.44 min in rats at the administration of 25 mg/kg .

HY-135319

Strictinin	Structural Classification Source classification Phenols Polyphenols Camellia sinensis (L.) O. Ktze. Plants Theaceae	Bacterial Antibiotic
Strictinin is a phenolic compound isolated from Pu'er teas. Strictinin has potential antiviral, antibacterial and laxative activities. Strictinin occurs by accelerating intestinal transit rather than enhancing gastric emptying, increasing food intake, or inducing diarrhea in rats.

HY-B0770

Artemotil 1 Publications Verification β-Arteether; (+)-Arteether; Arteether	Structural Classification Natural Products Classification of Application Fields Source classification Artemisia carvifolia Buch.-Ham. ex Roxb. Plants Compositae Disease Research Fields Cancer	CXCR Parasite
Artemotil (β-Arteether) has antimalarial activity for the treatment of chloroquine-resistant *Plasmodium falciparum* malaria with an IC₅₀ of 1.61 nM. Artemotil also has central nervous system (CNS) neurotoxicity and anorectic toxicity in rats, dogs and monkeys .

HY-N1131B

Triacetonamine monohydrate 2,2,6,6-Tetramethyl-4-piperidone monohydrate	Alkaloids Piperidine Alkaloids Structural Classification other families Classification of Application Fields Source classification Other Diseases Plants Disease Research Fields	Biochemical Assay Reagents
Triacetonamine (2,2,6,6-Tetramethyl-4-piperidone) monohydrate is used as an intermediate for the synthesis of pharmaceutical products, pesticides and photostabilizers for polymers. Triacetonamine hydrochloride has oral activity and can induce acute liver failure (ALF) in rats .

HY-N1131

Triacetonamine 1 Publications Verification 2,2,6,6-Tetramethyl-4-piperidone	Tribulus terrester Linn. Alkaloids Piperidine Alkaloids Structural Classification Classification of Application Fields Zygophyllaceae Source classification Other Diseases Plants Disease Research Fields	Biochemical Assay Reagents
Triacetonamine (2,2,6,6-Tetramethyl-4-piperidone) is used as an intermediate for the synthesis of pharmaceutical products, pesticides and photostabilizers for polymers. Triacetonamine has oral activity and can induce acute liver failure (ALF) in rats .

HY-N2086

Ethyl palmitate 2 Publications Verification Ethyl hexadecanoate	Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Other Diseases Dicerothamnus rhinocerotis Umbelliferae Plants Disease Research Fields	TNF Receptor Interleukin Related NF-κB
Ethyl palmitate (Ethyl hexadecanoate) is a CHIKV virus inhibitor with an EC₅₀ value of 0.0068 μM. Ethyl palmitate can reduce levels of TNF-α, IL-6, and NF-κB in endotoxemic rats, showing anti-inflammatory activity .

HY-124412

Paynantheine	Structural Classification Alkaloids Quinolizidine Alkaloids Source classification Rubiaceae Mitragyna speciosa Korth. Plants Indole Alkaloids	5-HT Receptor
Paynantheine is an alkaloid with antinociceptive activity, which is found in Mitragyna speciosa. Paynantheine is also a 5-HT_1AR and 5-HT_2BR agonist that induces lower lip retraction and antinociception in rats .

HY-N3015

Bruceine E	Structural Classification Simaroubaceae Classification of Application Fields Terpenoids Source classification Metabolic Disease Diterpenoids Plants Disease Research Fields Brucea javanica (L.) Merr.	Others
Bruceine E is a quassinoid from seeds of Brucea javanica (L.) Merr, exhibiting hypoglycemia effect . Bruceine E exhibits blood glucose lowering effect in both nondiabetic mice and Streptozotocin (STZ (HY-13753))-induced diabetic rats at lower dose .

HY-N15473

Isopaucifloral F (±)-Isopaucifloral F	Structural Classification Source classification Phenols Polyphenols Plants Dipterocarpaceae Vatica pauciflora (Korth.) Blume	Estrogen Receptor/ERR Drug Derivative
Isopaucifloral F ((±)-Isopaucifloral F) is a Resveratrol (HY-16561)-derived sesquiterpenes. Isopaucifloral F is an orally active ERβ agonist (EC₅₀: 46.96 μM). Isopaucifloral F has antiosteoporosis activity. LD₅₀ in rats: > 5 mg/kg .

Cat. No.	Product Name	Chemical Structure

HY-135761S

Penconazole-d7
Penconazole-d₇ is the deuterium labeled Penconazole[1]. Penconazole is a typical triazole fungicide, and mainly applied on apples, grapes, and vegetables to control powdery mildew. Penconazole inhibits sterol biosynthesis in fungi. Penconazole decrease AChE activity in the cerebrum and cerebellum of rats[2][3].

HY-B0476S

Phenacetin-d5
Phenacetin-d₅ is the deuterium labeled Phenacetin. Phenacetin (Acetophenetidin) is a non-opioid analgesic/antipyretic agent. Phenacetin is a selective COX-3 inhibitor. Phenacetin is used as probe of cytochrome P450 enzymes CYP1A2 in human liver microsomes and in rats[1][2][3].

HY-W012946S

2-Furoic acid-d3
2-Furoic acid-d₃ is the deuterium labeled 2-Furoic acid[1]. 2-Furoic acid (Furan-2-carboxylic acid) is an organic compound produced through furfural oxidation[2]. 2-Furoic acid exhibits hypolipidemic effet, lowers both serum cholesterol and serum triglyceride levels in rats[3].

HY-N2026S1

Propylparaben-d4

Propylparaben-d₄ is the deuterium labeled Propylparaben[1]. Propylparaben (Propyl parahydroxybenzoate) is an antimicrobial preservative which can be produced naturally by plants and bacteria. Propylparaben is prevalently used in cosmetics, pharmaceuticals, and foods. Propylparaben disrupts antral follicle growth and steroidogenic function by altering the cell-cycle, apoptosis, and steroidogenesis pathways. Propylparaben also decreases sperm number and motile activity in rats[2][3][4].

HY-W011873S2

Palmitoleic acid-13C16
Palmitoleic acid- ¹³C₁₆ is the ¹³C labeled Palmitoleic acid. Palmitoleic acid, a composition of fatty acid, is implicated in the prevention of death from cerebrovascular disorders in SHRSP rats.

HY-W011873S1

Palmitoleic acid-d13
Palmitoleic acid-d₁₃ is the deuterium labeled Palmitoleic acid. Palmitoleic acid, a composition of fatty acid, is implicated in the prevention of death from cerebrovascular disorders in SHRSP rats.

HY-B0476S1

Phenacetin-13C
Phenacetin- ¹³C is the ¹³C labeled Phenacetin[1]. Phenacetin (Acetophenetidin) is a non-opioid analgesic/antipyretic agent. Phenacetin is a selective COX-3 inhibitor. Phenacetin is used as probe of cytochrome P450 enzymes CYP1A2 in human liver microsomes and in rats[2][3][4].

HY-W750297

p,p'-DDD-13C12
p,p'-DDD- ¹³C₁₂ is ¹³C labeled p,p'-DDD. p,p'-DDD is a major metabolite of p,p'-DDT. p,p'-DDD occurs in the feces and livers of rats, that are given p,p'-DDT by stomach tube, but not of rats injected intraperitoneally with p,p'-DDT .

HY-B1448AS

(Rac)-Benidipine-d7
(Rac)-Benidipine-d₇ is the deuterium labeled Benidipine[1]. Benidipine is a potent and orally active calcium channel antagonist[2]. Benidipine shows anti-apoptosis effects in ischaemic/reperfused myocardial cells[3]. Benidipine increases the activity of endothelial cell-type nitric oxide synthase and improves coronary circulation in hypertensive rats[4].

HY-W011873S

Palmitoleic acid-d14
Palmitoleic acid-d₁₄ is the deuterium labeled Palmitoleic acid. Palmitoleic acid, a composition of fatty acid, is implicated in the prevention of death from cerebrovascular disorders in SHRSP rats.

HY-N0157S1

Orotic acid-13C,15N2 monohydrate

Orotic acid- ¹³C, ¹⁵N₂ (monohydrate) is the ¹³C and ¹⁵N labeled Orotic acid[1]. Orotic acid (6-Carboxyuracil), a precursor in biosynthesis of pyrimidine nucleotides and RNA, is released from the mitochondrial dihydroorotate dehydrogenase (DHODH) for conversion to UMP by the cytoplasmic UMP synthase enzyme. Orotic acid is a marker for measurement in routine newborn screening for urea cycle disorders. Orotic acid can induce hepatic steatosis and hepatomegaly in rats[2][3][4].

HY-B1971S

Deltamethrin-d5
Deltamethrin-d₅ is the deuterium labeled Deltamethrin. Deltamethrin (Decamethrin), a neurotoxic pyrethroid insecticide, produces a reversible sequence of motor symptoms in rats involving hind limb rigidity and choreoathetosis[1][2].

HY-101417S1

Diethyl phosphate-d10-1
Diethyl phosphate-d₁₀-1 is the deuterium labeled Diethyl phosphate. Diethylphosphate (Diethyl phosphoric acid) is an orally active organophosphorus pesticides metabolite. Diethylphosphate can interfere with thyroid hormone-related mechanisms and affect intestinal microbes in rats .

HY-B0099S

Edaravone-d5
Edaravone-d₅ is a deuterium labeled Edaravone. Edaravone is a strong novel free radical scavenger, and inhibits MMP-9-related brain hemorrhage in rats treated with tissue plasminogen activator[1][2][3][4].

HY-N1131S

Triacetonamine-d17
Triacetonamine-d17 (2,2,6,6-Tetramethyl-4-piperidone-d17) is the deuterium labeled Triacetonamine. Triacetonamine has oral activity and can induce acute liver failure (ALF) in rats .

HY-B1198S

Piperonyl butoxide-d9
Piperonyl butoxide-d₉ is the deuterium labeled Piperonyl butoxide.Piperonyl butoxide (ENT-14250) is a pesticide synergist and food additive. Piperonyl butoxide has adverse effects on reproduction, development and behavior in mice. Piperonyl butoxide can activate c-Jun and ATF-2 in mouse hepatocytes. Piperonyl butoxide is a liver cancer carcinogen in rats and mice .

HY-A0039S1

Eletriptan-d5
Eletriptan-d₅ is the deuterium labeled Eletriptan[1]. Eletriptan (UK-116044) is a highly selective and orally active serotonin 5-HT1B and 5-HT1D receptor agonist, with pKi values of 8.0 and 8.9, respectively. Eletriptan has inhibitory effects on markers of neurogenic inflammation in rats. Eletriptan can be used for researching migraine[2].

HY-N0264S1

Ligustrazine-d12

Ligustrazine-d₁₂ (Chuanxiongzine-d₁₂) is deuterium labeled Ligustrazine. Ligustrazine (Chuanxiongzine), an alkylpyrazine isolated from Ligusticum chuanxiong Hort. (Chuan Xiong) , is present in french fries, bread, cooked meats, tea, cocoa, coffee, beer, spirits, peanuts, filberts, dairy products and soy products as fragrance and flavouring ingredienexhibits. Ligustrazine also has potential nootropic and anti-inflammatory activities in rats .

HY-W010320S

Ethyl maltol-d5
Ethyl maltol-d₅ is the deuterium labeled Ethyl maltol. Ethyl maltol (2-Ethyl-3-hydroxy-4H-pyran-4-one) is an orally active and important food additive and flavor enhancer. Ethyl maltol is less toxic to rats and dogs. Ethyl maltol can enhance copper-mediated cytotoxicity and induce apoptosis in lung epithelial cells .

HY-W654020

Propyl paraben-13C6

Propyl paraben- ¹³C₆ (Propyl parahydroxybenzoate- ¹³C₆) is ¹³C labeled Propylparaben. Propylparaben (Propyl parahydroxybenzoate) is an antibacterial preservative that can be produced by plants and bacteria. Propylparaben is commonly used in cosmetics, pharmaceuticals and foods. Propylparaben disrupts follicular growth and steroidogenic function by altering cell cycle, apoptosis and steroidogenic pathways. Propylparaben also reduced sperm count and motility in rats .

HY-B0130S1

Perindopril-d5

Perindopril-d₅ (S-9490-d₅) is deuterium labeled Perindopril. Perindopril (S-9490) is an orally available, long-acting angiotensin-converting enzyme (ACE) inhibitor. Perindopril inhibits inflammatory cell influx and intimal thickening, preserving elastin on the inside of the aorta. Perindopril effectively inhibits experimental abdominal aortic aneurysm (AAA) formation in a rat model and reduces pulmonary vasoconstriction in rats with pulmonary hypertension .

HY-A0039S2

Eletriptan-d5 hydrochloride

Eletriptan-d₅ (hydrochloride) is the deuterium labeled Eletriptan hydrochloride[1]. Eletriptan (UK-116044) hydrochloride is a highly selective and orally active serotonin 5-HT1B and 5-HT1D receptor agonist, with pKi values of 8.0 and 8.9, respectively. Eletriptan hydrochloride has inhibitory effects on markers of neurogenic inflammation in rats. Eletriptan hydrochloride can be used for researching migraine[2].

HY-76569S1

(R)-Hydroxytolterodine-d14

(R)-Hydroxytolterodine-d₁₄ is deuterated labeled Desfesoterodine (HY-76569). Desfesoterodine (PNU-200577) is a potent and selective muscarinic receptor (mAChR) antagonist with a K_B and a pA₂ of 0.84 nM and 9.14, respectively . Desfesoterodine is a major pharmacologically active metabolite of Tolterodine (PNU-200583; HY-A0024) and Fesoterodine (HY-70053) . Desfesoterodine improves cerebral infarction induced detrusor overactivity in rats .

HY-N2026S

Propylparaben-d7

Propylparaben-d₇ (Propyl parahydroxybenzoate-d₇) is the deuterium labeled Propylparaben (HY-N2026) . Propylparaben (Propyl parahydroxybenzoate) is an antimicrobial preservative which can be produced naturally by plants and bacteria. Propylparaben is prevalently used in cosmetics, pharmaceuticals, and foods. Propylparaben disrupts antral follicle growth and steroidogenic function by altering the cell-cycle, apoptosis, and steroidogenesis pathways. Propylparaben also decreases sperm number and motile activity in rats .

HY-Y1275S

N-Methylpyrrolidone-d9

N-Methylpyrrolidone-d₉ (NMP-d₉) is deuterium labeled N-Methylpyrrolidone. N-Methylpyrrolidone (1-Methyl-2-pyrrolidinone), a five-membered cyclic amide, is an orally active organic polar solvent with teratogenicity and toxicity. N-Methylpyrrolidone is low in acute toxicity with a LD₅₀ value of 3914 mg/kg in rats and of 4050 mg/kg in mice. N-Methylpyrrolidone is extensively used in the manufacture of adhesives, paints, fuels, and pharmaceuticals .

HY-166341S

S 8849-1-d4 free base
S 8849-1-d₄ (free base) (Tianeptine metabolite MC5-d₄) is deuterium labeled S 8849-1 (free base). S 8849-1 (free base) (Tianeptine metabolite MC5) is a Tianeptine (HY-90003) metabolite that is found in plasma. The mean elimination half-lives of S 8849-1 (free base) is 7.53 h in rats. S 8849-1 (free base) is promising for research of antidepressants .

HY-B0124S2

Zonisamide-13C6

Zonisamide- ¹³C₆ (AD 810- ¹³C₆) is ¹³C labeled Zonisamide. Zonisamide (AD 810) is an orally active carbonic anhydrase inhibitor, with K_is of 35.2 and 20.6 nM for hCA II and hCA V, respectively. Zonisamide exerts neuroprotective effects through anti-apoptosis and upregulating MnSOD levels. Zonisamide also increases the expression of Hrd1, thereby improving cardiac function in AAC rats. Zonisamide can be used in studies of seizure, parkinson’s disease and cardiac hypertrophy .

HY-W014839S

Cyclamic acid-d11 sodium

Cyclamic acid-d₁₁ (Sodium cyclamate-d₁₁) sodiumis deuterium labeled Cyclamic acid (sodium). Cyclamic acid sodium (Sodium cyclamate) is a commonly used sweetener. Cyclamic acid sodium is toxic to osteoblasts and can inhibit cell proliferation, induce apoptosis and reduce cell mineralization. Cyclamic acid sodium causes focal necrosis of bladder organs in rats in vitro, which can promote bladder cancer, but some studies have shown that low doses of Cyclamic acid sodium have no carcinogenic effect. In addition, Cyclamic acid sodium has no effect on insulin and glucagon secretion induced by arginine .

HY-N0573S

Umbelliferone-d5

Umbelliferone-d₅ (7-Hydroxycoumarin-d₅) is the deuterium labeled Umbelliferone (HY-N0573 ). Umbelliferone (7-Hydroxycoumarin), a natural orally active product of the coumarin family, is a fluorescing compound which can be used as a sunscreen agent. Umbelliferone induces cell cycle arrest, apoptosis and DNA fragmentation in HepG2 cells. Umbelliferone exhibits significant anticancer effects. Umbelliferone attenuates the alteration characteristics of allergic airway inflammation. Umbelliferone displays the neuroprotective effects and cross the blood-brain barrier. Umbelliferone exhibits anti-inflammatory and antioxidant effects in chronic alcohol-fed rats .

HY-B1984S

p,p'-DDD-d8

p,p'-DDD-d₈ is the deuterium labeled p,p'-DDD[1]. p,p'-DDD (4,4’-DDD) is an organochlorine insecticide, a major metabolite of p,p'-DDT. p,p'-DDD is an agonist at estrogen receptor α(ERα) and ERβ. p,p'-DDD increases DNA damage, apoptosis and necrosis in peripheral blood. p,p'-DDD stimulates cell proliferation in SKBR3 cells. p,p'-DDD activates the AP-1 transcription factor. p,p'-DDD decreases sleep times of barbiturates and steroids in rats .

HY-W653921

Tenuazonic acid-d13

Tenuazonic acid-d₁₃ is deuterium labeled Tenuazonic acid. Tenuazonic acid is a nonhost-selective mycotoxin belonging to the tetramic acids family. Tenuazonic acid inhibits protein biosynthesis on ribosomes by suppressing the release of new protein. Tenuazonic acid is acutely toxic, and oral LD₅₀ is set between 81-186 mg/kg in rats and mice. Tenuazonic acid blocks electron transport beyond the primary quinone receptor (QA) by interacting with the D1 protein and is a photosystem II (PSII) inhibitor. In addition, Tenuazonic acid has antiviral effects on measles virus, enterovirus, respiratory virus and so on. Tenuazonic acid has an inhibitory effect on skin cancer .

Cat. No.	Product Name		Classification

HY-121528

Nilestriol Nylestriol; EE3CPE		Alkynes
Nilestriol is a estriol derivative, which inhibits osteoporosis on ovariectomized rats or postmenopausal women .

HY-118950

J 628		Alkynes
J 628 is an estrogen derivative used to study antifertility effects after sexual intercourse in mice, rats, and rabbits .

HY-120276

Golexanolone GR3027		Alkynes
Golexanolone is a GABA_A receptor modulating steroid antagonist. Golexanolone reduces peripheral inflammation and neuroinflammation and improves cognitive and motor function in hyperammonemic rats .

HY-120329

Lu 26-046		Alkynes
Lu 26-046 is the agonist for muscarinic M1 receptor and M2 receptor and a weak antagonist for M3 receptor, with K_i of 0.51, 26 and 5 nM, respectively. Lu 26-046 exhibits specific stimulus property, that can be recognized by rats .

Cat. No.	Product Name		Classification

HY-B1513

α-Cyclodextrin 2 Publications Verification		Others
α-Cyclodextrin (α-CD) is a soluble fiber derived from corn. α-Cyclodextrin can deplete sphingolipids and phospholipids from cell membranes. α-Cyclodextrin interacts with tubulin. α-Cyclodextrin improves defenses against SARS-CoV-2 infection. α-Cyclodextrin enhances the anticancer efficacy of Crcumin (HY-N0005) against breast, lung and cervical cancer. α-Cyclodextrin has beneficial effects on body weight and blood lipids .

HY-152927

Hydroxypropylmethyl cellulose acetate succinate (Mw: 20-100k Da)		Release-retarding Agents
Hydroxypropylmethyl cellulose acetate succinate (Mw: 20-100k Da) is a cosolvent for preparing SDDs of low-solubility agents. Hydroxypropylmethyl cellulose acetate succinate (Mw: 20-100k Da) exhibits no acute/subchronic/chronic toxicity in rats, with oral activity and LD₅₀ >2.5 g/kg .

HY-N7103

Ethyl oleate		Solvents
Ethyl oleate is an orally active fatty acid ester formed from the condensation of oleic acid and ethanol. Ethyl oleate is the main fatty acid ethyl ester in the blood after alcohol ingestion. Ethyl oleate has no obvious toxicity to rats and its absorption, distribution and excretionare similar to triacylglycerol. Ethyl oleate can accelerate the drying process of certain foods and can also be used as a liquid lipid component in nanostructured lipid carriers .

HY-W014839

Cyclamic acid sodium Sodium cyclamate; Cyclohexylsulfamic acid sodium		Sweetening Agents
Cyclamic acid sodium (Sodium cyclamate) is a commonly used sweetener. Cyclamic acid sodium is toxic to osteoblasts and can inhibit cell proliferation, induce apoptosis and reduce cell mineralization. Cyclamic acid sodium causes focal necrosis of bladder organs in rats in vitro, which can promote bladder cancer, but some studies have shown that low doses of Cyclamic acid sodium have no carcinogenic effect. In addition, Cyclamic acid sodium has no effect on insulin and glucagon secretion induced by arginine .

HY-153808B

Complete Freund's adjuvant (CFA, 1 mg/ml)		Adjuvant
Complete Freund's adjuvant (CFA, 1 mg/ml) is an immunoadjuvant emulsified with antigen that can enhance an animal's immune response to an antigen. Complete Freund's adjuvant (CFA, 1 mg/ml) is also an inducer of the Th1 immune response and a ligand of TLRs. Complete Freund's adjuvant (CFA, 1 mg/ml) contains heat-killed inactive tuberculosis bacilli and consists of a paraffin oil-in-water emulsion. Complete Freund's adjuvant (CFA, 1 mg/ml) stimulates a strong and durable immune response and can be used to induce rheumatoid arthritis in rats, and more .

HY-150214

ODN MT01		CpG ODNs
ODN MT01 was designed based on human mitochondrial DNA sequences, which is an inhibitory ODN that promotes osteocyte differentiation. ODN MT01 could promote osteoblast maturation and activation in rats, reduce rat alveolar bone absorption caused by periodontitis, regulate the expression levels of osteogenesis-related factors.

HY-150214A

ODN MT 01 sodium		CpG ODNs
ODN MT01 sodium was designed based on human mitochondrial DNA sequences, which is an inhibitory ODN that promotes osteocyte differentiation. ODN MT01 sodium could promote osteoblast maturation and activation in rats, reduce rat alveolar bone absorption caused by periodontitis, regulate the expression levels of osteogenesis-related factors.

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

rats.

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

NaturalProducts

Isotope-Labeled Compounds

Click Chemistry

Oligonucleotides

Natural
Products