2. GPCR/G Protein Neuronal Signaling
  3. mGluR
  4. VU6031545

VU6031545 is a potent mGlu 5 negative allosteric modulator with an IC50 of 15 nM. VU6031545 has excellent brain penetrant and oral bioavailability in rats.

For research use only. We do not sell to patients.

VU6031545 Chemical Structure

VU6031545 Chemical Structure

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VU6031545 Related Antibodies

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Description

VU6031545 is a potent mGlu 5 negative allosteric modulator with an IC50 of 15 nM. VU6031545 has excellent brain penetrant and oral bioavailability in rats[1].

Molecular Weight

361.44

Formula

C16H15N3O3S2
SMILES

O=C(NC1=NC(C)=CS1)C2=NC3=C(SC=C3)C(O[C@@H]4CCOC4)=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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VU6031545 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VU6031545VU 6031545VU-6031545mGluRMetabotropic glutamate receptorslevodopa-induced dyskinesiaParkinson’s diseaseInhibitorinhibitorinhibit

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