2. Cell Cycle/DNA Damage
  3. Polo-like Kinase (PLK)
  4. CZL-S092

CZL-S092 is a PLK4 inhibitor with an IC50 value of 0.9 nM and excellent selectivity over other PLK4 family members (PLK1, PLK2, and PLK3).CZL-S092 exhibits anti-neuroblastoma activity in vitro (IMR-32 cells, IC50 = 1.143 μM) and acceptable oral bioavailability in vivo (SD rats, F = 22.1%). CZL-S092 can be used in studies of various cancers including neuroblastoma cancer.

For research use only. We do not sell to patients.

CZL-S092 Chemical Structure

CZL-S092 Chemical Structure

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CZL-S092 Related Antibodies

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Description

CZL-S092 is a PLK4 inhibitor with an IC50 value of 0.9 nM and excellent selectivity over other PLK4 family members (PLK1, PLK2, and PLK3).CZL-S092 exhibits anti-neuroblastoma activity in vitro (IMR-32 cells, IC50 = 1.143 μM) and acceptable oral bioavailability in vivo (SD rats, F = 22.1%). CZL-S092 can be used in studies of various cancers including neuroblastoma cancer[1].

In Vitro

CZL-S092 (0.5 μM; 60 min) exhibits a significantly increased suppression activity with an IC50 value of 0.9 nM[1].
CZL-S092 (0.5-2.5 μM; 5 d) exhibits the optimal antiproliferative activity against MCF-7, IMR-32 and SH-SY5Y cells with IC50 values of 2.828 μM, 1.143 μM, and 1.329 μM, respectively[1].
CZL-S092 (0.5-5 μM; 48 h) induces significant apoptosis (84.3%) in IMR-32 neuroblastoma cells[1].
CZL-S092 (2.5 μM; 48 h) arrestes IMR-32 cells at G2/M phase (87.4%)[1].
CZL-S092 (5.0 μM; 24 h) significantly suppresses IMR-32 cell migration ( > 90%) [1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CZL-S092 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: MCF-7, IMR-32, SH-SY5Y
Concentration: 0.5 μM, 1.0 μM, 2.5 μM
Incubation Time: 5 days
Result: Exhibited the optimal antiproliferative activity against MCF-7, IMR-32 and SH-SY5Y cells with IC50 values of 2.828 μM, 1.143 μM, and 1.329 μM, respectively.

Cell Cycle Analysis[1]

Cell Line: IMR-32
Concentration: 1.0 μM, 2.5 μM, 5.0 μM
Incubation Time: 48 h
Result: Produced a remarkable 87.4% and 89.6% G2/M phase arrest at a concentration of 2.5 μM and 5.0 μM.

Apoptosis Analysis[1]

Cell Line: IMR-32
Concentration: 1.0 μM, 2.5 μM, 5.0 μM
Incubation Time: 48 h
Result: Induced the total rate to 84.3% at a concentration of 2.50 μM, and 90.2% at 5.0 μM.

Cell Migration Assay [1]

Cell Line: IMR-32
Concentration: 1.0 μM, 2.5 μM, 5.0 μM
Incubation Time: 24 h
Result: Significantly suppressed over 90% of the wound healing with 5.0 μM.

Immunofluorescence[1]

Cell Line: IMR-32
Concentration: 2.5 μM
Incubation Time: 48 h
Result: Occurred disordered centrosome replication and resulted in centriole loss. T.
Molecular Weight

418.49

Formula

C23H19FN4OS
SMILES

CN(C1=CC=CC(F)=C1)C(CSC2=CC3=C(C(/C=C/C4=CC=CN=C4)=NN3)C=C2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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CZL-S092 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CZL-S092Polo-like Kinase (PLK)PLK4 inhibitorsIndazole derivativesNeuroblastomaVirtual screeningFragment-based drug designInhibitorinhibitorinhibit

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