2. Vitamin D Related/Nuclear Receptor
  3. Estrogen Receptor/ERR
  4. LY2066948

LY2066948 is a selective and orally active estrogen receptor modulator (SERM). LY2066948 has high affinity for estrogen receptors ERα and ERβ (Ki: 0.51 and 1.36 nM respectively) and shows potent antiestrogenic activity. LY2066948 blocks uterine weight gain induced by Ethynyl estradiol (HY-B0216) in immature rats. LY2066948 can be used for research of uterine fibroids and myomas.

For research use only. We do not sell to patients.

LY2066948

LY2066948 Chemical Structure

CAS No. : 648904-56-7

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LY2066948 Related Antibodies

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Estrogen receptor ERα ERβ ERRα ERRβ ERRγ

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Description

LY2066948 is a selective and orally active estrogen receptor modulator (SERM). LY2066948 has high affinity for estrogen receptors ERα and ERβ (Ki: 0.51 and 1.36 nM respectively) and shows potent antiestrogenic activity. LY2066948 blocks uterine weight gain induced by Ethynyl estradiol (HY-B0216) in immature rats. LY2066948 can be used for research of uterine fibroids and myomas[1][2].

Cellular Effect
Cell Line Type Value Description References
Ishikawa IC50
10.7 nM
Compound: 4b
Inhibition of estrogen stimulation in human Ishikawa cells by alkaline phosphatase quantitation
Inhibition of estrogen stimulation in human Ishikawa cells by alkaline phosphatase quantitation
[PMID: 17482463]
Molecular Weight

517.64

Formula

C30H31NO5S
CAS No.
SMILES

OC1=CC=C2C(OC3=CC=C(C=C3)OCCN4CCCCC4)=C(C=CC2=C1)C5=CC=C(C=C5)S(=O)(C)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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LY2066948 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LY2066948648904-56-7LY 2066948LY-2066948Estrogen Receptor/ERRuterine fibroidsmyomasInhibitorinhibitorinhibit

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