Search Result
Results for "
broad-spectrum activity
" in MedChemExpress (MCE) Product Catalog:
9
Biochemical Assay Reagents
93
Isotope-Labeled Compounds
Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
-
- HY-17373
-
-
-
- HY-101476
-
Bay 44-4400
|
Parasite
|
Infection
|
Emodepside (PF 1022-221) is a cyclooctadepsipeptide with broad-spectrum anthelmintic activity.
|
-
-
- HY-14762
-
|
Antibiotic
Bacterial
|
Infection
|
Besifloxacin is a fluoroquinolone antimicrobial agent. Besifloxacin can inhibit cytokine production by monocytes. Besifloxacin has broad-spectrum antibacterial activity .
|
-
-
- HY-106922
-
GV104326
|
Antibiotic
Bacterial
|
Infection
|
Sanfetrinem (GV104326) is a β-lactamase-stable antibiotic. Sanfetrinem has broad-spectrum antimicrobial activity against both Gram-positive and Gram-negative bacteria .
|
-
-
- HY-P10536
-
|
Bacterial
|
Infection
|
Temporin SHF is a broad-spectrum antimicrobial peptide that is active against Gram-positive and Gram-negative bacteria and yeasts, but does not have hemolytic activity. Temporin SHF disrupts the acyl chain stacking of anionic lipid bilayers, leading to cracks and disintegration of microbial membranes. Temporin SHF can be used in the development of antimicrobial drugs .
|
-
-
- HY-123192
-
Sansalid
|
Parasite
|
Infection
|
Uredofos is a broad-spectrum anthelmintic. Uredofos has anticestodal activity .
|
-
-
- HY-17373A
-
SCH56592 hydrate
|
Fungal
Parasite
|
Infection
Cancer
|
Posaconazole hydrate is a broad-spectrum, second generation, triazole compound with antifungal activity.
|
-
-
- HY-156975
-
|
Bacterial
|
Infection
|
Sulfatrozole is a sulfanilamide derivative. Sulfatrozole is an antimicrobial agent with broad-spectrum activity .
|
-
-
- HY-105113
-
-
-
- HY-167256
-
-
-
- HY-N14967
-
|
Bacterial
|
Infection
|
Epicillin is found in the strain of Semisynthetic broad-spectrum penicillin with antibacterial activities .
|
-
-
- HY-161986
-
|
HIV
|
Infection
|
HIV-1 inhibitor-74 (compound 10c) is a potent HIV-1 inhibitor with an EC50 value of 0.0047 µM for HIV-1 IIIB. HIV-1 inhibitor-74 shows cytotoxicity. HIV-1 inhibitor-74 inhibits WT HIV-1 RT activity with an IC50 value of 0.134 µM. HIV-1 inhibitor-74 shows broad-spectrum anti HIV-1 activity .
|
-
-
- HY-169174
-
|
Fungal
|
Cancer
|
Antifungal agent 116 (compund 1a) has broad-spectrum antifungal activity .
|
-
-
- HY-169811
-
-
-
- HY-A0153
-
-
-
- HY-A0153A
-
Cefapirin sodium
|
Bacterial
Antibiotic
|
Infection
|
Cephapirin sodium (Cefapirin sodium) is an ephalosporin antibiotic with broad-spectrum antimicrobial activity .
|
-
-
- HY-119280
-
-
-
- HY-N14168
-
|
Bacterial
|
Infection
|
Ashimycin A is a Streptomycin (HY-B1906) analogue with a broad-spectrum antibacterial activity .
|
-
-
- HY-106339
-
-
-
- HY-106141
-
UR 9825
|
Fungal
|
Infection
|
Albaconazole (UR 9825) is a broad-spectrum triazole and oral activity antifungal agent .
|
-
-
- HY-N7111
-
Sultamicillin (tosilate)
|
Bacterial
Antibiotic
|
Infection
|
Sultamicillin tosylate is a broad-spectrum and orally active beta-lactamase inhibitor, an antibiotic with antibacterial activity .
|
-
-
- HY-N14170
-
|
Bacterial
|
Infection
|
Ashimycin B is a Streptomycin (HY-B1906) analogue with a broad-spectrum antibacterial activity .
|
-
-
- HY-114927
-
SL 11010
|
Fungal
|
Infection
|
(±)-Dunnione (SL 11010) is a compound with broad-spectrum antifungal activity that acts by initiating redox cycling .
|
-
-
- HY-N7115
-
|
Bacterial
Antibiotic
|
Infection
|
Sultamicillin is a broad-spectrum and orally active beta-lactamase inhibitor, an antibiotic with antibacterial activity .
|
-
-
- HY-115364
-
SKF 29044
|
Microtubule/Tubulin
Parasite
|
Infection
|
Parbendazole is a potent inhibitor of microtubule assembly, destabilizes tubulin, with an EC50 of 530 nM, and exhibits a broad-spectrum anthelmintic activity.
|
-
-
- HY-P5582
-
|
Bacterial
|
Infection
|
Combi-1 is an antimicrobial peptide with broad-spectrum activity against different bacteria and yeast cells .
|
-
-
- HY-101865
-
|
Bacterial
|
Infection
|
KKL-10 is a small-molecule ribosome rescue inhibitor with broad-spectrum antimicrobial activity against bacteria.
|
-
-
- HY-B1366A
-
|
Antibiotic
Bacterial
|
Infection
|
Meclocycline is a tetracycline antibiotic with broad-spectrum antibacterial activities, preventing skin bacterial infections such as acne vulgarisis .
|
-
-
- HY-14814
-
RX-3341; WQ-3034; ABT492
|
Bacterial
Antibiotic
|
Infection
|
Delafloxacin (RX-3341; WQ-3034; ABT492) is a broad-spectrum fluoroquinolone antibiotic. Delafloxacin has a broad spectrum of activity that includes drug-resistant Staphylococcus aureus, Streptococcus pneumoniae, and Klebsiella pneumonia .
|
-
-
- HY-B1366
-
|
Antibiotic
Bacterial
|
Infection
|
Meclocycline Sulfosalicylate Salt is a tetracycline antibiotic with broad-spectrum antibacterial activities, preventing skin bacterial infections such as acne vulgaris .
|
-
-
- HY-W002677
-
|
Antibiotic
Bacterial
|
Infection
|
Fluoroquinolonic acid is a bacteriostatic antibiotic. Fluoroquinolonic acid has broad-spectrum activity against Gram-positive and Gram-negative bacteria .
|
-
-
- HY-139713
-
|
Fungal
|
Infection
|
Antifungal agent 14 exhibits broad-spectrum activity against the fungal strains with excellent minimum inhibitory concentration values.
|
-
-
- HY-W516735
-
|
Fungal
Succinate Dehydrogenase
|
Infection
|
Sedaxane is a new broad-spectrum seed treatment fungicide. Sedaxane inhibits fungal respiration by binding to the succinate dehydrogenase complex in fungal mitochondria. Sedaxane has broad-spectrum activity against a variety of seed-borne and soil-borne fungi. Sedaxane can be used in the study of barley loose smut and barley stripe disease .
|
-
-
- HY-109125A
-
SPA-S-753; SPA-S-752 L-aspartate
|
Antibiotic
Fungal
|
Infection
|
Amcipatricin diaspartate (SPA-S-753) is a semi-synthetic polyene antibiotic, with potent broad-spectrum antifungal activity .
|
-
-
- HY-106681
-
Fungichromin; Pentamycin; Cogomycin
|
Antibiotic
Fungal
|
Cancer
|
Lagosin (Fungichromin) is a polyene macrolide antibiotic. Lagosin has demonstrated broad-spectrum antifungal activity and is impervious to agent resistance .
|
-
-
- HY-N14066
-
|
Fungal
|
Infection
|
Ascochitine, a polyketide-derived secondary metabolite, is a selective antifungal agent. Ascochitine exhibits broad-spectrum phytotoxicity and antimicrobial activities .
|
-
-
- HY-174219
-
|
Bacterial
|
Infection
|
BT-33 is a fuorinated macrobicyclic oxepanoprolinamide antibiotic with broad-spectrum activity against multidrug-resistant bacterial pathogens .
|
-
-
- HY-129034
-
|
Bacterial
Antibiotic
|
Infection
|
Ramoplanin is a broad-spectrum lipoglycodepsipeptide antibiotic derived from the Actinoplanes spp with with activity against gram-positive bacteria .
|
-
-
- HY-124801
-
ABMA
1 Publications Verification
|
Flavivirus
Dengue Virus
Bacterial
Parasite
|
Infection
|
ABMA is a broad-spectrum inhibitor of intracellular toxins and pathogens. ABMA efficiently protects cells against various toxins and pathogens including viruses, intracellular bacteria and parasite. ABMA selectively acts at host cell late endosomes rather than targeting toxin or pathogen itself. ABMA has broad-spectrum anti-infection activity .
|
-
-
- HY-P1612
-
|
Antibiotic
Bacterial
|
Infection
|
Hormaomycin is a potent and selective macrocyc antibiotic agent. Hormaomycin has broad-spectrum antibiotic activity against numerous Gram-positive .
|
-
-
- HY-U00249
-
R66905
|
Fungal
|
Infection
|
Saperconazole (R66905) is a broad-spectrum antifungal triazole and has potent activity against Aspergillus with an MIC90 of 0.19 mg/L.
|
-
-
- HY-A0076
-
LJC 11036
|
Bacterial
Antibiotic
|
Infection
|
Tebipenem is an orally available carbapenem antibiotic, shows broad-spectrum activity against Gram-positive and -negative bacteria, except for Pseudomonas aeruginosa.
|
-
-
- HY-14814A
-
ABT492 meglumine; RX-3341 meglumine; WQ-3034 meglumine
|
Bacterial
Antibiotic
|
Infection
|
Delafloxacin meglumine (ABT492 meglumine; RX-3341 meglumine; WQ-3034 meglumine) is a broad-spectrum fluoroquinolone antibiotic. Delafloxacin has a broad spectrum of activity that includes drug-resistant Staphylococcus aureus, Streptococcus pneumoniae, and Klebsiella pneumonia .
|
-
-
- HY-17373S
-
SCH 56592-d5
|
Isotope-Labeled Compounds
Fungal
|
Infection
|
Posaconazole-d5 is a deuterium-labeled form of Posaconazole. Posaconazole is a broad-spectrum, second generation, triazole compound with antifungal activity .
|
-
-
- HY-17373S1
-
SCH 56592-d4
|
Fungal
|
Infection
|
Posaconazole-d4 is a deuterium-labeled form of Posaconazole. Posaconazole is a broad-spectrum, second generation, triazole compound with antifungal activity .
|
-
-
- HY-N0306
-
|
Enterovirus
|
Infection
|
Hederasaponin B, isolated from Hedera helix, has broad-spectrum antiviral activity against various subgenotypes of Enterovirus 71 (EV71).
|
-
-
- HY-123451
-
|
Bacterial
|
Infection
|
ACH-702 is a potent anti-tubercular agent. ACH-702 also shows broad-spectrum antibacterial activity .
|
-
-
- HY-120753
-
|
Fungal
|
Infection
|
Rimocidin, a polyene macrolide, is an antifungal compound. Rimocidin shows broad‐spectrum antifungal activity against multiple plant‐pathogenic fungi .
|
-
-
- HY-17373R
-
SCH 56592 (Standard)
|
Reference Standards
Fungal
Parasite
|
Infection
Cancer
|
Posaconazole (Standard) is the analytical standard of Posaconazole. This product is intended for research and analytical applications. Posaconazole is a broad-spectrum, second generation, triazole compound with antifungal activity.
|
-
-
- HY-108279
-
|
Antibiotic
Bacterial
|
Infection
|
Ulifloxacin is a broad-spectrum quinolone antibiotic. Ulifloxacin is the active metabolite of Prulifloxacin (HY-B0024). Ulifloxacin has anti-bacterial activity .
|
-
- HY-14934
-
STA 5312
|
Microtubule/Tubulin
|
Cancer
|
Rosabulin (STA 5312) is a potent and orally active microtubule inhibitor that inhibits microtubule assembly. Rosabulin has broad-spectrum anti-tumor activity .
|
-
- HY-101476R
-
Bay 44-4400 (Standard)
|
Reference Standards
Parasite
|
Infection
|
Emodepside (Standard) is the analytical standard of Emodepside. This product is intended for research and analytical applications. Emodepside (PF 1022-221) is a cyclooctadepsipeptide with broad-spectrum anthelmintic activity.
|
-
- HY-116489
-
LGC-40863
|
Herbicide
|
Others
|
Pyribenzoxim (LGC-40863) is a broad-spectrum herbicide. Pyribenzoxim has a higher safety level in bentgrass and a stronger herbicidal activity on grass weeds .
|
-
- HY-149309
-
|
Topoisomerase
|
Infection
|
Topoisomerase inhibitor 2 (18C) is a bacterial topoisomeraseinhibitor that exhibits potent broad-spectrum activity against multidrug-resistant Gram-negative bacteria .
|
-
- HY-14814S
-
RX-3341-d5; WQ-3034-d5; ABT492-d5
|
Isotope-Labeled Compounds
Bacterial
Antibiotic
|
Infection
|
Delafloxacin-d5 is deuterium labeled Delafloxacin. Delafloxacin (RX-3341; WQ-3034; ABT492) is a broad-spectrum fluoroquinolone antibiotic. Delafloxacin has a broad spectrum of activity that includes drug-resistant Staphylococcus aureus, Streptococcus pneumoniae, and Klebsiella pneumonia .
|
-
- HY-123614
-
|
Bacterial
|
Infection
|
PD 140248 hydrochloride is a quinolone broad-spectrum antibacterial agent with good in vitro bacteriostatic activity, especially having a significant inhibitory effect on Gram-positive bacteria .
|
-
- HY-B0734A
-
SCE-963 hydrochloride
|
Antibiotic
Bacterial
|
Infection
|
Cefotiam (SCE-963) hydrochloride is a parenteral cephalosporin antibiotic. Cefotiam hydrochloride has broad-spectrum activity against Gram-positive and Gram-negative bacteria .
|
-
- HY-B0734
-
SCE-963; Cefotiam Dihydrochloride
|
Antibiotic
Bacterial
|
Infection
|
Cefotiam (SCE-963) is a parenteral cephalosporin antibiotic. Cefotiam has broad-spectrum activity against Gram-positive and Gram-negative bacteria .
|
-
- HY-Z16210
-
Nebramine factor 5′; 6′′-O-Carbamoyltobramycin
|
Antibiotic
Bacterial
|
Infection
|
Nebramycin V' (Nebramine factor 5′) is a multi-component aminoglycoside antibiotic with a broad-spectrum activity against Gram-positive and Gram-negative bacteria and mycobacteria .
|
-
- HY-B0734B
-
SCE-963 dihydrochloride hydrate
|
Antibiotic
Bacterial
|
Infection
|
Cefotiam (SCE-963) dihydrochloride hydrate is a parenteral cephalosporin antibiotic. Cefotiam dihydrochloride hydrate has broad-spectrum activity against Gram-positive and Gram-negative bacteria .
|
-
- HY-106922A
-
GV104326 sodium
|
Antibiotic
Bacterial
|
Infection
|
Sanfetrinem (GV104326) sodium is a beta-lactamase-stable antibiotic. Sanfetrinem sodium has broad-spectrum activity against gram-positive and gram-negative bacteria .
|
-
- HY-Y1777
-
|
Drug Derivative
|
Infection
|
2-Phenylacetophenone has broad-spectrum efflux pump inhibition activity. 2-Phenylacetophenone is a benzoin derivative used as a photoinitiator in vinyl polymerization .
|
-
- HY-156777
-
|
Others
|
Cancer
|
Antiproliferative agent-36 (compound 8i) is a benzothiazolyl hydrazones derived compound with antiproliferative activity. Antiproliferative agent-36 has a broad-spectrum anticancer activity .
|
-
- HY-115364S
-
-
- HY-A0107S
-
|
Bacterial
Antibiotic
|
Infection
|
Tetracycline-d6 is the deuterium labeled Tetracycline. Tetracycline is a broad-spectrum antibiotic, exhibiting activity against a wide range of gram-positive and gram-negative bacteria.
|
-
- HY-123271
-
|
Bacterial
Antibiotic
|
Infection
|
Ro 23-9424 is a broad-spectrum cephalosporin composed of a cephalosporin and a quinolone moiety. Ro 23-9424 shows antimicrobial activity in vivo and in vitro .
|
-
- HY-109754
-
PF-03709270
|
Bacterial
Antibiotic
|
Infection
|
Sulopenem etzadroxil (PF-03709270) is an orally available ester proagent form of sulopenem, with broad-spectrum antibacterial activity against most gram-positive and gram-negative bacteria.
|
-
- HY-A0153R
-
Cefapirin (Standard)
|
Reference Standards
Antibiotic
Bacterial
|
Infection
|
Cephapirin (Standard) is the analytical standard of Cephapirin. This product is intended for research and analytical applications. Cephapirin (Cefapirin) is an ephalosporin antibiotic with broad-spectrum antimicrobial activity .
|
-
- HY-A0153AR
-
Cefapirin sodium (Standard)
|
Reference Standards
Bacterial
Antibiotic
|
Infection
|
Cephapirin (sodium) (Standard) is the analytical standard of Cephapirin (sodium). This product is intended for research and analytical applications. Cephapirin sodium (Cefapirin sodium) is an ephalosporin antibiotic with broad-spectrum antimicrobial activity .
|
-
- HY-P3349
-
|
Bacterial
|
Infection
|
c[Arg-Arg-Arg-Arg-Nal-Nal-Nal] (Compound 9C) shows broad-spectrum activity against drug-resistant Gram-positive and Gram-negative bacteria, with MICs of 3.1, 3,1, 12.5, and 25 μg/mL for MRSA (ATCC BAA-1556), S. aureus (ATCC 29213), P. aeruginosa (ATCC 27883), and E. coli (ATCC 25922), respectively .
|
-
- HY-14814R
-
RX-3341 (Standard); WQ-3034 (Standard); ABT492 (Standard)
|
Reference Standards
Bacterial
Antibiotic
|
Infection
|
Delafloxacin (Standard) is the analytical standard of Delafloxacin. This product is intended for research and analytical applications. Delafloxacin (RX-3341; WQ-3034; ABT492) is a broad-spectrum fluoroquinolone antibiotic. Delafloxacin has a broad spectrum of activity that includes drug-resistant Staphylococcus aureus, Streptococcus pneumoniae, and Klebsiella pneumonia .
|
-
- HY-N0565
-
Doxycycline
Maximum Cited Publications
123 Publications Verification
|
MMP
Bacterial
Antibiotic
Parasite
|
Infection
Cancer
|
Doxycycline, an antibiotic, is an orally active and broad-spectrum metalloproteinase (MMP) inhibitor . Doxycycline shows antibacterial activity and anti-cancer cell proliferation activity .
|
-
- HY-115441
-
(Rac)-NND 502
|
Antibiotic
Fungal
|
Infection
|
(Rac)-Luliconazole ((Rac)-NND 502) is the racemic isomer of Luliconazole (HY-14283). Luliconazole is a topical antifungal imidazole antibiotic with broad-spectrum and potent antifungal activity .
|
-
- HY-112542
-
CL-287088; LL-F28249 α
|
Parasite
Antibiotic
|
Infection
|
Nemadectin (CL-287088), an orally active broad-spectrum endectocide, is highly efficacious against natural infections of all the major canine gastrointestinal helminthes. Anthelmintic activity .
|
-
- HY-N7066
-
|
Bacterial
Antibiotic
|
Infection
|
Difloxacin hydrochloride is a broad-spectrum antibacterial agent. Difloxacin hydrochloride inhibits bacterial DNA gyrase and exhibits a concentration-dependant bactericidal effect by interference with the activity of DNA gyrase and topoisomerase IV .
|
-
- HY-B1444
-
|
Bacterial
Fungal
Antibiotic
|
Infection
|
Isoconazole nitrate is a broad-spectrum antimicrobial agent with a highly effective antimycotic and gram-positive antibacterial activity, exhibiting a rapid rate of absorption and low systemic exposure potential .
|
-
- HY-151418
-
|
Fungal
|
Infection
|
Chitin synthase inhibitor 8 is a chitin synthase (CHS) inhibitor with broad-spectrum antifungal activity. Chitin synthase inhibitor 8 can be used in the research of fungi infection .
|
-
- HY-B2012
-
DPX-H6573
|
Fungal
|
Infection
|
Flusilazole (DPX-H6573), an organosilane fungicide, has broad-spectrum antifungal effect. Flusilazole exhibits curative and preventative activities and is recommended for use in agriculture and horticulture .
|
-
- HY-17373S3
-
SCH 56592-d7
|
Isotope-Labeled Compounds
|
Infection
Cancer
|
Posaconazole-d7 (SCH 56592-d7) is deuterium labeled Posaconazole. Posaconazole is a broad-spectrum, second generation, triazole compound with antifungal activity.
|
-
- HY-W015026
-
-
- HY-147822
-
|
Apoptosis
|
Cancer
|
Apoptosis inducer 6 (compound 4e) is an anticancer agent with a broad-spectrum anticancer activity. Apoptosis inducer 6 triggers cell death through the induction of apoptosis .
|
-
- HY-17373S2
-
-
- HY-151419
-
|
Fungal
|
Infection
|
Chitin synthase inhibitor 9 is a chitin synthase (CHS) inhibitor with broad-spectrum antifungal activity. Chitin synthase inhibitor 9 can be used in the research of fungi infection .
|
-
- HY-P3348
-
|
Bacterial
|
Infection
|
c[Arg-Arg-Arg-Arg-Dip-Dip-Dip] (Compound 8C) shows broad-spectrum activity against drug-resistant Gram-positive and Gram-negative bacteria, with MICs of 3.1, 3,1, 12.5, and 12.5 μg/mL for MRSA (ATCC BAA-1556), S. aureus (ATCC 29213), P. aeruginosa (ATCC 27883), and E. coli (ATCC 25922), respectively .
|
-
- HY-A0059R
-
NF 113 (Standard); SAP 113 (Standard); Methylmercadone (Standard)
|
Reference Standards
Bacterial
Parasite
Antibiotic
|
Infection
|
Nifuratel (Standard) is the analytical standard of Nifuratel. This product is intended for research and analytical applications. Nifuratel (NF 113, SAP 113) is a broad-spectrum antibiotic with activity against bacteria, fungi and trichomonas.
|
-
- HY-108009
-
Biafungin; CD101; SP-3025
|
Fungal
|
Infection
|
Rezafungin (Biafungin) is a next-generation, broad-spectrum, and long-lasting echinocandin. Rezafungin shows potent antifungal activity against Candida spp., Aspergillus spp., and Pneumocystis spp. .
|
-
- HY-142127
-
Vistamycin; SF-733
|
Bacterial
Antibiotic
PDI
|
Infection
|
Ribostamycin (Vistamycin) is a broad-spectrum aminoglycoside antibiotic. Ribostamycin is effective against Gram-Negative and Gram-Positive bacterial infection. Ribostamycin also inhibits the chaperone activity of PDI .
|
-
- HY-108009A
-
Biafungin acetate; CD101 acetate; SP-3025 acetate
|
Fungal
|
Infection
|
Rezafungin acetate (Biafungin acetate) is a next-generation, broad-spectrum, and long-lasting echinocandin. Rezafungin acetate shows potent antifungal activity against Candida spp., Aspergillus spp., and Pneumocystis spp. .
|
-
- HY-N7111R
-
Sultamicillin (tosilate) (Standard)
|
Reference Standards
Bacterial
Antibiotic
|
Infection
|
Sultamicillin (tosylate) (Standard) is the analytical standard of Sultamicillin (tosylate). This product is intended for research and analytical applications. Sultamicillin tosylate is a broad-spectrum and orally active beta-lactamase inhibitor, an antibiotic with antibacterial activity .
|
-
- HY-B0529
-
|
Bacterial
Parasite
Antibiotic
|
Infection
|
Azlocillin, an antibiotic, is a semisynthetic penicillin, and has broad-spectrum antibacterial activity. Azlocillin is active against drug-tolerant B. burgdorferi sensu stricto JLB31 infection .
|
-
- HY-B0187A
-
S 4661 monohydrate
|
Bacterial
Antibiotic
|
Infection
|
Doripenem (S 4661) monohydrate, a 1β-methyl parenteral carbapenem, has very broad-spectrum activity against Gram-positive and Gram-negative aerobic bacteria .
|
-
- HY-B0841
-
-
- HY-B0187
-
S 4661
|
Bacterial
Antibiotic
|
Infection
|
Doripenem (S 4661), a 1β-methyl parenteral carbapenem, has very broad-spectrum activity against Gram-positive and Gram-negative aerobic bacteria .
|
-
- HY-N7115R
-
|
Reference Standards
Bacterial
Antibiotic
|
Infection
|
Sultamicillin (Standard) is the analytical standard of Sultamicillin. This product is intended for research and analytical applications. Sultamicillin is a broad-spectrum and orally active beta-lactamase inhibitor, an antibiotic with antibacterial activity .
|
-
- HY-N7449
-
-
- HY-B0455A
-
SC47111A; NY-198
|
Bacterial
Antibiotic
|
Infection
|
Lomefloxacin (SC47111A) is a broad-spectrum quinolone antibiotic, with antimicrobial activity. Lomefloxacin is used for the research of respiratory tract infections, genitourinary infections, gastrointestinal infections, ENT infections, etc. .
|
-
- HY-175313
-
|
Bacterial
|
Infection
|
Antibacterial agent 286 (compound 5) is an effective broad-spectrum antimicrobial agent with strong inhibitory activity against methicillin-resistant S. aureus (MRSA) with an MIC of 25 μg/mL .
|
-
- HY-P2794
-
-
- HY-B0474R
-
|
Reference Standards
Bacterial
Antibiotic
|
Infection
Cancer
|
Tetracycline (hydrochloride) (Standard) is the analytical standard of Tetracycline (hydrochloride). This product is intended for research and analytical applications. Tetracycline (hydrochloride) is a broad-spectrum antibiotic, exhibiting activity against a wide range of gram-positive and gram-negative bacteria.
|
-
- HY-151632
-
|
Carbonic Anhydrase
|
Cancer
|
hCAIX-IN-15 is a potent hCA IX inhibitor with a Ki value of 38.8 nM. hCAIX-IN-15 shows good broad-spectrum anticancer activity and can be used for cancer research .
|
-
- HY-115364R
-
SKF 29044 (Standard)
|
Reference Standards
Microtubule/Tubulin
Parasite
|
Infection
|
Parbendazole (Standard) is the analytical standard of Parbendazole. This product is intended for research and analytical applications. Parbendazole is a potent inhibitor of microtubule assembly, destabilizes tubulin, with an EC50 of 530 nM, and exhibits a broad-spectrum anthelmintic activity.
|
-
- HY-170801
-
|
Others
|
Neurological Disease
|
Anticonvulsant agent 7 (Compound 19) is an orally active broad-spectrum anticonvulsant that demonstrates excellent anticonvulsive activity in both the MES (maximal electroshock seizure) and 6 Hz epilepsy modelsmouse .
|
-
- HY-128514
-
Oxazinomycin
|
Antibiotic
Bacterial
|
Infection
Cancer
|
Minimycin (Oxazinomycin) is a nucleoside antibiotic with a broad-spectrum antibacterial activity. Minimycin has inhibitory effect on mouse Ehrlich ascites carcinoma, ascites type and solid type sarcoma-180 .
|
-
- HY-A0294
-
MK-0826
|
Antibiotic
Bacterial
|
Infection
Cancer
|
Ertapenem (MK-0826) is a broad spectrum and long acting β-lactam antibiotic. Ertapenem has a broad-spectrum anti-anaerobic activity against a variety of anaerobes with a mode MIC of 0.12 μg/mL. Ertapenem can be used for the research of severe infections caused by bacteria in the skin, lungs, stomach, pelvis, and urinary tract .
|
-
- HY-13625
-
L-749345; MK-826
|
Bacterial
Antibiotic
|
Infection
Cancer
|
Ertapenem sodium (L-749345) is a broad spectrum and long acting β-lactam antibiotic. Ertapenem sodium has a broad-spectrum anti-anaerobic activity against a variety of anaerobes with a mode MIC of 0.12 μg/mL. Ertapenem sodium can be used for the research of severe infections caused by bacteria in the skin, lungs, stomach, pelvis, and urinary tract .
|
-
- HY-152132
-
|
CCR
HIV
|
Infection
|
CCR5 antagonist 3 (Compound 26) is a CCR5 antagonist with an IC50 of 15.90 nM. CCR5 antagonist 3 shows broad-spectrum anti-HIV-1 activities .
|
-
- HY-N0168S
-
|
p38 MAPK
Apoptosis
Autophagy
|
Neurological Disease
|
Hesperetin-d3 is the deuterium labeled Hesperetin . Hesperetin is a natural flavanone, and acts as a potent and broad-spectrum inhibitor against human UGT activity. Hesperetin regulates apoptosis .
|
-
- HY-W002677R
-
|
Reference Standards
Antibiotic
Bacterial
|
Infection
|
Fluoroquinolonic acid (Standard) is the analytical standard of Fluoroquinolonic acid. This product is intended for research and analytical applications. Fluoroquinolonic acid is a bacteriostatic antibiotic. Fluoroquinolonic acid has broad-spectrum activity against Gram-positive and Gram-negative bacteria .
|
-
- HY-157804
-
|
PROTACs
SARS-CoV
|
Infection
|
PROTAC SARS-CoV-2 Mpro degrader-1 (compound 5) is a PROTAC degrader targeting the major SARS-CoV-2 protease with broad-spectrum antiviral activity .
|
-
- HY-113216R
-
-
- HY-152131
-
|
CCR
HIV
|
Infection
|
CCR5 antagonist 2 (Compound 25) is a CCR5 antagonist with an IC50 of 8.34 nM. CCR5 antagonist 2 shows broad-spectrum anti-HIV-1 activities .
|
-
- HY-B1128B
-
Cephamandole lithium
|
Antibiotic
Bacterial
|
Infection
|
Cefamandole (Cephamandole) lithium is a second-generation broad-spectrum cephalosporin antibiotic with antibacterial activity. Cefamandole lithium breaks down in the body and then releases free NMTT, which can lead to low prothrombinemia .
|
-
- HY-105393
-
Antibiotic LB 10517 sodium
|
Bacterial
|
Infection
|
LB 10517 (sodium) is a type of cephalosporin. LB 10517 (sodium) has broad-spectrum antibacterial activity against both Gram-positive and Gram-negative bacteria, including Enterobacteriaceae, Pseudomonas aeruginosa, Staphylococcus, and Streptococcus .
|
-
- HY-149067
-
|
Fungal
|
Infection
|
Antifungal agent 47 (compound 3b) shows the highest and broad-spectrum fungicidal activity, strong respiratory inhibition activity, and adenosine 5′-triphosphate synthesis inhibition activity. Antifungal agent 47 is potential as a fungicide .
|
-
- HY-14814AR
-
ABT492 meglumine (Standard); RX-3341 meglumine (Standard); WQ-3034 meglumine (Standard)
|
Reference Standards
Bacterial
Antibiotic
|
Infection
|
Delafloxacin (meglumine) (Standard) is the analytical standard of Delafloxacin (meglumine). This product is intended for research and analytical applications. Delafloxacin meglumine (ABT492 meglumine; RX-3341 meglumine; WQ-3034 meglumine) is a broad-spectrum fluoroquinolone antibiotic. Delafloxacin has a broad spectrum of activity that includes drug-resistant Staphylococcus aureus, Streptococcus pneumoniae, and Klebsiella pneumonia[1].
|
-
- HY-B0474
-
|
Antibiotic
Bacterial
|
Infection
Cancer
|
Tetracycline hydrochloride is a broad-spectrum antibiotic with oral activity. Tetracycline hydrochloride exhibits activity against a wide range of bacteria including gram-positive, gram-negative bacteria, chlamydiae, mycoplasmas and rickettsiae. Tetracycline hydrochloride can be used for the research of infections .
|
-
- HY-169175
-
|
Antibiotic
Bacterial
|
Infection
|
CN-CC-861 is a broad-spectrum antibiotic. CN-CC-861 shows antibiotic activities for susceptible and multidrug-resistant bacteria. CN-CC-861 shows potent bactericidal activity in vivo .
|
-
- HY-12643
-
-
- HY-A0107
-
MK-801 maleate
|
Antibiotic
Bacterial
|
Infection
Cancer
|
Tetracycline is a broad-spectrum antibiotic with oral activity. Tetracycline exhibits activity against a wide range of bacteria including gram-positive, gram-negative bacteria, chlamydiae, mycoplasmas and rickettsiae. Tetracycline can be used for the research of infections .
|
-
- HY-16468
-
MSI-1256
|
Bacterial
HBV
FAK
Dengue Virus
|
Infection
Neurological Disease
Cancer
|
Squalamine (MSI-1256) is an aminosterol compound with broad-spectrum antiviral activity. Squalamine makes cells less conducive to certain viral replication by altering the electrostatic interactions in the inner membrane of host cells. Squalamine also has antibacterial and antitumor activities. Squalamine has broad-spectrum antibacterial activity against Gram-negative and Gram-positive bacteria, fungi and protozoa. Squalamine inhibits tumor-related angiogenesis and the growth of human breast cancer cells. Squalamine restores the function of enteric nervous system in Parkinson ,s disease mouse models .
|
-
- HY-115349
-
|
Antibiotic
Bacterial
|
Infection
Neurological Disease
Cancer
|
Neamine tetrahydrochloride, a degradation product of Neomycin, is a broad-spectrum aminoglycoside antibiotic. Neamine tetrahydrochloride is an anti-angiogenesis agent targeting angiogenin. Neamine tetrahydrochloride has potent antibacterial, antitumor and neuroprotective activities .
|
-
- HY-N7095
-
CTZ
|
Bacterial
Antibiotic
|
Infection
|
Ceftezole (CTZ) is a broad-spectrum cephem antibiotic against many species of gram-positive and gram-negative bacteria. Ceftezole (CTZ) is an alpha-glucosidase inhibitor with in vivo anti-diabetic activity .
|
-
- HY-N7529
-
|
Endogenous Metabolite
β-glucuronidase
|
Others
|
Siastatin B is an effective broad-spectrum glycosidase inhibitor that can effectively inhibit the activities of sialidase, β-D-glucuronidase, N-acetyl-glucosaminidase, β-glucuronidase, and human heparinase .
|
-
- HY-N7096
-
CTZ sodium
|
Bacterial
Antibiotic
|
Infection
|
Ceftezole sodium (CTZ sodium) is a broad-spectrum cephem antibiotic against many species of gram-positive and gram-negative bacteria. Ceftezole sodium (CTZ sodium) is an alpha-glucosidase inhibitor with in vivo anti-diabetic activity .
|
-
- HY-B0834
-
(RS)-Indoxacarb; DPX-JW062
|
Sodium Channel
|
Neurological Disease
|
Indoxacarb ((±)-Indoxacarb; DPX-JW062) is a broad-spectrum oxadiazine insecticide with high insecticidal activity and low mammalian toxicity. Indoxacarb blocks insect sodium channels (Sodium Channel) in nerve preparations and isolated neurons .
|
-
- HY-157028
-
|
Others
|
Infection
|
Antiparasitic agent-19 (compound 40) is a compound with broad-spectrum antiparasitic activity. Antiparasitic agent-19 has minimal toxicity against Trypanosoma brucei, Leishmania Infantum, and Trypanosoma cruzi .
|
-
- HY-103251
-
LpxC-4
|
Antibiotic
Bacterial
|
Infection
|
PF-5081090 (LpxC-4) is a potent LpxC inhibitor, is a rapidly bactericidal with broad-spectrum activity. PF-5081090 serves as a regulator of lipid A biosynthesis in Gram-negative pathogens .
|
-
- HY-147360
-
|
nAChR
|
Infection
|
Tribendimidine is an orally active, broad-spectrum anthelmintic agent, with particularly high activity against A. lumbricoides and N. americanus. Tribendimidine is also an L-type nicotinic acetylcholine receptor (nAChR) agonist .
|
-
- HY-118036
-
|
Topoisomerase
|
Infection
|
ACT-387042 is a bacterial topoisomerase inhibitor with broad-spectrum activity against Gram-positive and Gram-negative bacteria, including methicillin-resistant Staphylococcus aureus and penicillin- and fluoroquinolone-resistant Streptococcus pneumoniae .
|
-
- HY-N6737
-
|
Bacterial
Antibiotic
|
Infection
|
Aureothricin is a dithiolopyrrolone (DTP) antibiotic first isolated from Streptomyces and exhibits relatively broad-spectrum antibiotic activity. Aureothricin can inhibit adhesion of human umbilical vein endothelial cells (HUVECs) to vitronectin .
|
-
- HY-W127442
-
Ethyl 2-Ethylbutyrate
|
Bacterial
|
Others
|
Etzadroxil (Ethyl 2-Ethylbutyrate) is a volatile ester compound. Sulopenem Etzadroxil is an orally available ester proagent form of Sulopenem, an antibiotic with broad-spectrum activities against Gram-positive and Gram-negative bacteria .
|
-
- HY-155569
-
|
Fungal
|
Infection
|
Chitin synthase inhibitor 13 (compound 12g) is a non-competitive inhibitor of chitin synthase, with an IC50 of 106.7 μM. Chitin synthase inhibitor 13 exhibits a broad-spectrum of antifungal activity .
|
-
- HY-P5691
-
|
Bacterial
|
Infection
Cancer
|
P1 is a broad-spectrum antimicrobial peptide. P1 shows antibacterial activity against Gram-positive and Gram-negative bacteria,such as B. anthracis spores and Carbapenem-resistant A. baumannii and K. pneumoniae .
|
-
- HY-A0294A
-
MK-0826 disodium
|
Bacterial
Antibiotic
|
Infection
Cancer
|
Ertapenem (MK-0826) disodium is a broad spectrum and long acting β-lactam antibiotic. Ertapenem disodium has a broad-spectrum anti-anaerobic activity against a variety of anaerobes with a mode MIC of 0.12 μg/mL. Ertapenem disodium can be used for the research of severe infections caused by bacteria in the skin, lungs, stomach, pelvis, and urinary tract .
|
-
- HY-129347
-
T-2636E
|
Antibiotic
Bacterial
|
Infection
|
Lankacyclinol A is an orally active antibiotic isolated from Streptomyces rochei. Lankacyclinol A has broad-spectrum antimicrobial activity against both Gram-positive and Gram-negative bacteria. Lankacyclinol A exhibits low toxicity in mice .
|
-
- HY-135307
-
Huanjunzuo
|
Fungal
|
Infection
|
SSF-109 is a broad-spectrum fungicide which has protective activity against plant disease. SSF-109 inhibits the biosynthesis of ergosterol at the 14α-demethylation step in Botrytis cinerea .
|
-
- HY-B0458A
-
|
Antibiotic
Bacterial
|
Infection
|
Cefprozil is a second-generation cephalosporin type antibiotic. Cefprozil exhibits broad-spectrum antibacterial activity, and is orally active. Cefprozil can be used for the study of pharyngitis, tonsillitis, otitis media, and uncomplicated skin infections .
|
-
- HY-B1366R
-
|
Reference Standards
Antibiotic
Bacterial
|
Infection
|
Meclocycline (Sulfosalicylate Salt) (Standard) is the analytical standard of Meclocycline (Sulfosalicylate Salt). This product is intended for research and analytical applications. Meclocycline Sulfosalicylate Salt is a tetracycline antibiotic with broad-spectrum antibacterial activities, preventing skin bacterial infections such as acne vulgaris .
|
-
- HY-B0458
-
|
Antibiotic
Bacterial
|
Infection
|
Cefprozil monohydrate is a second-generation cephalosporin type antibiotic. Cefprozil monohydrate exhibits broad-spectrum antibacterial activity, and is orally active. Cefprozil monohydrate can be used for the study of pharyngitis, tonsillitis, otitis media, and uncomplicated skin infections .
|
-
- HY-P5561
-
|
Antibiotic
Bacterial
|
Infection
|
Aurein 2.2 is a major component of the skin secretion of L.aurea. Aurein 2.2 is an antibiotic with broad-spectrum antibacterial activity against Gram positive bacteria such as Staphylococcus aureus and S. epidermidis .
|
-
- HY-B0455B
-
SC47111A (aspartate); NY-198 (aspartate)
|
Bacterial
Antibiotic
|
Infection
|
Lomefloxacin (SC47111A) aspartate is a broad-spectrum quinolone antibiotic, with antimicrobial activity. Lomefloxacin aspartate can be used for researching respiratory tract infections, genitourinary infections, gastrointestinal infections, ENT infections, etc. .
|
-
- HY-158061A
-
|
Topoisomerase
Apoptosis
|
Cancer
|
Topoisomerase II inhibitor 20 TFA is a potent topoisomerase II inhibitor with IC50 of 0.98 µM. Topoisomerase II inhibitor 20 TFA can induce apoptosis and has broad-spectrum anticancer activity .
|
-
- HY-P10352
-
|
Bacterial
|
Infection
|
Pediocin PA-1 is a broad-spectrum lactic acid bacterial bacteriocin that inhibits the activity of foodborne pathogens such as Listeria monocytogenes and Gram-positive bacteria. Pediocin PA-1 can be used as a food biopreservative .
|
-
- HY-W018025
-
-
- HY-A0076R
-
LJC 11036 (Standard)
|
Reference Standards
Bacterial
Antibiotic
|
Infection
|
Tebipenem (Standard) is the analytical standard of Tebipenem. This product is intended for research and analytical applications. Tebipenem is an orally available carbapenem antibiotic, shows broad-spectrum activity against Gram-positive and -negative bacteria, except for Pseudomonas aeruginosa.
|
-
- HY-A0088A
-
-
- HY-122046
-
|
Endogenous Metabolite
|
Infection
|
Amb123203 is an antiviral compound with the activity of inhibiting viral budding. Amb123203 exerts its effect by blocking the interaction between mVP40 and Nedd4 proteins. Amb123203 has a significant inhibitory effect on the budding of VP40 virus-like particles (VLPs) of Marburg (MARV) and Ebola viruses. Amb123203 can effectively target RNA viruses that rely on the PPxY L domain for efficient budding, showing broad-spectrum antiviral activity. The discovery of Amb123203 provides an important basis for the development of new broad-spectrum antiviral compounds .
|
-
- HY-16721
-
Filociclovir; ZSM-I-62; MBX-400
|
CMV
|
Infection
|
Cyclopropavir (Filociclovir) is an orally active and broad-spectrum anti-herpesvirus compound. Cyclopropavir inhibits UL97 kinase activity. Cyclopropavir has antiviral activity against HCMV, MCMV, and HAdV6 viruses .
|
-
- HY-134608
-
-
- HY-A0088
-
Cefotaxim sodium; HR-756 sodium
|
Beta-lactamase
Bacterial
Antibiotic
|
Infection
|
Cefotaxime (Cefotaxim) sodium, a β-lactamase stable cephalosporin and a third-generation cephalosporin antibiotic, possesses broad-spectrum antibiotic activity against numerous Gram-positive and Gram-negative bacteria .
|
-
- HY-14283
-
NND 502
|
Fungal
Antibiotic
|
Infection
|
Luliconazole (NND 502) is a topical antifungal imidazole antibiotic with broad-spectrum and potent antifungal activity. Luliconazole can be used for the research of skin infection, including dermatophytosis, tinea corporis, tinea pedis et al .
|
-
- HY-110253
-
HIV-1 inhibitor 18A
|
HIV
|
Infection
|
18A (HIV-1 inhibitor 18A) is a reversible broad-spectrum HIV-1 inhibitor. 18A exhibits broad inhibitory activity against multiple HIV-1 strains by blocking the function of Env .
|
-
- HY-158061
-
|
Topoisomerase
Apoptosis
|
Cancer
|
Topoisomerase II inhibitor 20 (Compound 3e) is a potent topoisomerase II (Topoisomerase II) inhibitor with an IC50 of 0.98 µM. Topoisomerase II inhibitor 20 induces apoptosis and has broad-spectrum anticancer activity .
|
-
- HY-W015026S
-
-
- HY-146884
-
|
c-Met/HGFR
VEGFR
|
Cancer
|
MET kinase-IN-3 (compound 8) is an orally active and potent MET inhibitor, with an IC50 of 9.8 nM. MET kinase-IN-3 shows good and broad-spectrum antiproliferative activity against cancer cell lines .
|
-
- HY-108279R
-
|
Antibiotic
Bacterial
Reference Standards
|
Infection
|
Ulifloxacin (Standard) is the analytical standard of Ulifloxacin. This product is intended for research and analytical applications. Ulifloxacin is a broad-spectrum quinolone antibiotic. Ulifloxacin is the active metabolite of Prulifloxacin (HY-B0024). Ulifloxacin has anti-bacterial activity .
|
-
- HY-P10352A
-
|
Bacterial
|
Infection
|
Pediocin PA-1 TFA is a broad-spectrum lactic acid bacterial bacteriocin that inhibits the activity of foodborne pathogens such as Listeria monocytogenes and Gram-positive bacteria. Pediocin PA-1 TFA can be used as a food biopreservative .
|
-
- HY-19961
-
KIN1408
1 Publications Verification
|
Flavivirus
Dengue Virus
HCV
|
Infection
|
KIN1408 is an agonist of the RIG-1-like receptor (RLR) pathway and exhibits a broad-spectrum antiviral activity. KIN1408 exhibits activity against HCV, influenza A, dengue virus 2, Ebola, Nipah, and Lassa viruses .
|
-
- HY-N0565A
-
|
MMP
Bacterial
Antibiotic
Parasite
|
Infection
Cancer
|
Doxycycline hydrochloride, an antibiotic, is an orally active and broad-spectrum metalloproteinase (MMP) inhibitor . Doxycycline hydrochloride shows antibacterial activity and anti-cancer cell proliferation activity. Doxycycline hydrochloride can be used to construct gene expression regulation models .
|
-
- HY-N0565AS
-
|
Isotope-Labeled Compounds
Bacterial
Antibiotic
MMP
Parasite
|
Infection
Cancer
|
Doxycycline-d3 hydrochloride is deuterium labeled Doxycycline (hydrochloride). Doxycycline hydrochloride, an antibiotic, is an orally active and broad-spectrum metalloproteinase (MMP) inhibitor . Doxycycline hydrochloride shows antibacterial activity and anti-cancer cell proliferation activity .
|
-
- HY-148992
-
|
Calcineurin
Fungal
|
Infection
|
APX879 is a fungal-specific calcineurin inhibitor that has less immunosuppressive activities and toxicities. APX879 is a C22-modified FK506 (HY-13756) analog, which maintains broad-spectrum antifungal activity .
|
-
- HY-W015881R
-
NSC-16045 (Standard); NSC-741804 (Standard)
|
Drug Intermediate
Reference Standards
|
Others
|
Hederasaponin B (Standard) is the analytical standard of Hederasaponin B. This product is intended for research and analytical applications. Hederasaponin B, isolated from Hedera helix, has broad-spectrum antiviral activity against various subgenotypes of Enterovirus 71 (EV71).
|
-
- HY-N0306R
-
|
Reference Standards
Enterovirus
|
Infection
|
Hederasaponin B (Standard) is the analytical standard of Hederasaponin B. This product is intended for research and analytical applications. Hederasaponin B, isolated from Hedera helix, has broad-spectrum antiviral activity against various subgenotypes of Enterovirus 71 (EV71).
|
-
- HY-155546
-
|
Bacterial
|
Infection
|
Antimicrobial agent-22 (THI 6c) is a multi-target broad-spectrum antibacterial agent. Antimicrobial agent-22 has low cytotoxicity, hemolytic property, rapid bactericidal ability and good anti-biofilm activity .
|
-
- HY-B0159
-
Q-35
|
Bacterial
Antibiotic
|
Infection
|
Balofloxacin (Q-35) is an orally active fluoroquinolone antibiotic with broad-spectrum antibacterial activity against gram-negative, gram-positive, and anaerobic bacteria. Balofloxacin can be used for the research of respiratory, intestinal, and urinary tract infections .
|
-
- HY-10445
-
Azoline; R126638
|
Fungal
|
Infection
|
Pramiconazole is a broad-spectrum antifungal agent with oral activity. Pramiconazole has a good affinity for 14α-demethylase. Pramiconazole can be used in the study of fungal infections in the local skin, hair, nails, oral cavity, and genital mucosa .
|
-
- HY-163114
-
|
p38 MAPK
|
Metabolic Disease
|
2-Stearoxyphenethyl phosphocholin (compound 1a) is a p38 MAPK inhibitor with anticancer activity. 2-Stearoxyphenethyl phosphocholin may bind to the p38 MAPK lipid-binding pocket and has broad-spectrum anti-tumor and lipid-modulating activities .
|
-
- HY-N0565B
-
Doxycycline hydrochloride hemiethanolate hemihydrate; WC2031
|
Antibiotic
MMP
Bacterial
Parasite
|
Infection
Cancer
|
Doxycycline hyclate, an antibiotic, is an orally active and broad-spectrum metalloproteinase (MMP) inhibitor. Doxycycline hyclate shows antibacterial activity and anti-cancer cell proliferation activity. Doxycycline hyclate can be used to construct gene expression regulation models .
|
-
- HY-163115
-
|
p38 MAPK
|
Cancer
|
2-Oleoxyphenethyl phosphocholin (compound 1b) is a p38 MAPK inhibitor with anticancer activity. 2-Oleoxyphenethyl phosphocholin may bind to the p38 MAPK lipid-binding pocket and has broad-spectrum anti-tumor and lipid-modulating activities .
|
-
- HY-N0565AR
-
|
Reference Standards
MMP
Bacterial
Antibiotic
Parasite
|
Infection
Cancer
|
Doxycycline (hydrochloride) (Standard) is the analytical standard of Doxycycline (hydrochloride). This product is intended for research and analytical applications. Doxycycline hydrochloride, an antibiotic, is an orally active and broad-spectrum metalloproteinase (MMP) inhibitor . Doxycycline hydrochloride shows antibacterial activity and anti-cancer cell proliferation activity [4] .
|
-
- HY-N0565R
-
|
Reference Standards
MMP
Bacterial
Antibiotic
Parasite
|
Infection
Cancer
|
Doxycycline (Standard) is the analytical standard of Doxycycline. This product is intended for research and analytical applications. Doxycycline, an antibiotic, is an orally active and broad-spectrum metalloproteinase (MMP) inhibitor . Doxycycline shows antibacterial activity and anti-cancer cell proliferation activity [4] .
|
-
- HY-W355463
-
|
Microtubule/Tubulin
|
Neurological Disease
Inflammation/Immunology
Cancer
|
3-Demethylthiocolchicine is a colchicine (HY-16569) analog with broad-spectrum antitumor activity. 3-Demethylthiocolchicine has the same effects and activities as colchicine in blocking casein-induced amyloidosis, microtubule binding, and anti-inflammatory effects, with significantly lower toxicity .
|
-
- HY-W042191
-
|
Fungal
Apoptosis
Caspase
Bcl-2 Family
MDM-2/p53
PARP
|
Infection
Cancer
|
Oxychloroaphine could be isolated from the bacterium Pantoea agglomerans naturally present in soil. Oxychloroaphine has broad-spectrum antifungal activity. Oxychloroaphine has cytotoxicity in a dose-dependent manner and induces apoptosis. Oxychloroaphine can be used in research of cancer .
|
-
- HY-59097
-
(E/Z)-WBI-1001; (E/Z)-Benvitimod; (E/Z)-GSK2894512
|
Antibiotic
Bacterial
Fungal
|
Infection
|
(E/Z)-Tapinarof ((E/Z)-WBI-1001; 3,5-dihydroxy-4-isopropylstilbene) is a broad-spectrum antibiotic. (E/Z)-Tapinarof has anti-bacterial, anti-fungal and anti-nematode activities .
|
-
- HY-W774918
-
|
Fungal
|
|
Oxaziclomefone is a broad-spectrum pesticide with fungal activity. Oxaziclomefone effectively controls a variety of crop diseases and has significant effects against plant pathogenic fungi. Oxaziclomefone is widely used in agriculture to protect crops from diseases and improve crop yield and quality.
|
-
- HY-155769
-
|
Fungal
|
Infection
|
Antimicrobial agent-24 (compound E8) is a hydrazide compound with excellent and broad-spectrum fungicidal activities. Antimicrobial agent-24 affects the normal function of the plasma membrane, further generating changes in the morphology and subcellular structure of mycelia .
|
-
- HY-B0455S
-
SC47111A-d5 hydrochloride; NY-198-d5 hydrochloride
|
Isotope-Labeled Compounds
|
Inflammation/Immunology
|
Lomefloxacin-d5 (hydrochloride) is the deuterium labeled Lomefloxacin hydrochloride. Lomefloxacin (SC47111A) hydrochloride is a broad-spectrum quinolone antibiotic, with antimicrobial activity. Lomefloxacin hydrochloride is used for the research of respiratory tract infections, genitourinary infections, gastrointestinal infections, ENT infections, etc. .
|
-
- HY-B1228
-
Vistamycin sulfate
|
Bacterial
Antibiotic
PDI
|
Infection
|
Ribostamycin sulfate (Vistamycin sulfate) is a broad-spectrum antimicrobial, inhibits bacterial protein synthesis at the level of 30S and 50S ribosomal subunit binding, also inhibits the chaperone activity of protein disulfide isomerase (PDI), used in pharmacokinetic and nephrotoxicity studies
|
-
- HY-13625R
-
L-749345 (Standard); MK-826 (Standard)
|
Reference Standards
Bacterial
Antibiotic
|
Infection
Cancer
|
Ertapenem sodium (Standard) is the analytical standard of Ertapenem sodium. This product is intended for research and analytical applications. Ertapenem sodium (L-749345) is a broad spectrum and long acting β-lactam antibiotic. Ertapenem sodium has a broad-spectrum anti-anaerobic activity against a variety of anaerobes with a mode MIC of 0.12 μg/mL. Ertapenem sodium can be used for the research of severe infections caused by bacteria in the skin, lungs, stomach, pelvis, and urinary tract[1][2].
|
-
- HY-N0565C
-
|
MMP
Bacterial
Antibiotic
Parasite
|
Infection
Cancer
|
Doxycycline calcium, an antibiotic, is an orally active and broad-spectrum metalloproteinase (MMP) inhibitor . Doxycycline calcium shows antibacterial activity and anti-cancer cell proliferation activity. Doxycycline calcium can be used to construct gene expression regulation models .
|
-
- HY-12643R
-
-
- HY-N0168AS
-
-
- HY-143408
-
|
Bacterial
|
Infection
|
OYYF-175, an antimicrobial antifolate, is a dihydrofolate reductase (DHFR) inhibitor with an IC50 of 2.36 nM for Escherichia coli DHFR. OYYF-175 exhibits potent broad-spectrum antibacterial activities, especially against multi-drug resistant Gram-Negative-strains .
|
-
- HY-B2012R
-
DPX-H6573 (Standard)
|
Reference Standards
Fungal
|
Infection
|
Flusilazole (Standard) is the analytical standard of Flusilazole. This product is intended for research and analytical applications. Flusilazole (DPX-H6573), an organosilane fungicide, has broad-spectrum antifungal effect. Flusilazole exhibits curative and preventative activities and is recommended for use in agriculture and horticulture .
|
-
- HY-W015026R
-
-
- HY-112542R
-
CL-287088 (Standard); LL-F28249 α (Standard)
|
Reference Standards
Parasite
Antibiotic
|
Infection
|
Nemadectin (Standard) is the analytical standard of Nemadectin. This product is intended for research and analytical applications. Nemadectin (CL-287088), an orally active broad-spectrum endectocide, is highly efficacious against natural infections of all the major canine gastrointestinal helminthes. Anthelmintic activity .
|
-
- HY-118547
-
2-Benzyl-4-chlorophenol
|
Bacterial
|
Infection
|
Clorofene (2-Benzyl-4-chlorophenol) is an aryl halide fungicide widely used in hospitals and homes as a broad-spectrum fungicide in general cleaning and disinfection disinfectant solutions and in soap formulations. Clorofene has antibacterial and carcinogenic activity .
|
-
- HY-14907
-
MPC 6827
|
Microtubule/Tubulin
|
Cancer
|
Verubulin (MPC-6827) is a highly potent and broad-spectrum microtubule blocker. Verubulin has antitumor activity against breast cancer, melanoma, and ovarian cancer. Verubulin can be used in non-small cell lung cancer research .
|
-
- HY-W740165
-
|
Antibiotic
Drug Metabolite
|
Infection
|
Desmethyl Levofloxacin hydrochloride is an antibacterial agent with broad-spectrum antibacterial activity against a variety of pathogens. Desmethyl Levofloxacin hydrochloride effectively fights bacterial infections by inhibiting bacterial DNA synthesis. Studies on Desmethyl Levofloxacin hydrochloride have shown that it has potential in inhibiting respiratory infections .
|
-
- HY-137498
-
|
Filovirus
|
Infection
|
EBOV/MARV-IN-1 is a potent inhibitor of Ebola virus (EBOV) and Marburg virus (MARV), with broad-spectrum activity (EC50=0.31, and 0.82 µM, respectively) and low cytotoxicity (SI>100) in HeLa cells .
|
-
- HY-172260
-
|
Protoporphyrinogen IX oxidase
Herbicide
|
Others
|
PPO-IN-20 (Compound B18) is a Protoporphyrinogen IX oxidase (PPO, protoporphyrinogen IX oxidase) inhibitor, with a Ki value of 10.3 nM for NtPPO. PPO-IN-20 shows broad-spectrum herbicidal activity and can be used for research in the agricultural field .
|
-
- HY-N7066R
-
|
Reference Standards
Bacterial
Antibiotic
|
Infection
|
Difloxacin (hydrochloride) (Standard) is the analytical standard of Difloxacin (hydrochloride). This product is intended for research and analytical applications. Difloxacin hydrochloride is a broad-spectrum antibacterial agent. Difloxacin hydrochloride inhibits bacterial DNA gyrase and exhibits a concentration-dependant bactericidal effect by interference with the activity of DNA gyrase and topoisomerase IV .
|
-
- HY-112047
-
GSK2878175
|
HCV
|
Infection
|
GSK8175 is a non-nucleoside polymerase (NS5B) inhibitor of hepatitis C virus (HCV). GSK8175 is a sulfonamide- N-benzoxaborole analog with low in vivo clearance across preclinical species and broad-spectrum activity against HCV replicons .
|
-
- HY-18234
-
-
- HY-162517
-
|
Orthopoxvirus
|
Infection
|
UMM-766 is an orally available nucleoside analog. UMM-766 has potent, broad-spectrum antiviral activity against multiple members of the pox virus family. UMM-766 provides protection in a murine model of orthopox disease .
|
-
- HY-172960
-
|
SARS-CoV
Virus Protease
|
Infection
Inflammation/Immunology
|
SARS-CoV-2 Mpro-IN-44 (Compound 25) is a broad-spectrum coronavirus main protease (Mpro) inhibitor. SARS-CoV-2 Mpro-IN-44 has inhibitory activity against a variety of high-risk coronaviruses (including SARS-CoV-2 and PEDV, etc.) (IC50: < 0.6 μM). SARS-CoV-2 Mpro-IN-44 achieves broad-spectrum inhibition of coronaviruses by enhancing the interaction with the conserved sites of Mpro. SARS-CoV-2 Mpro-IN-44 can be used for anti-coronavirus drug development .
|
-
- HY-108016
-
Encordin
|
Src
PI3K
JNK
STAT
EGFR
Apoptosis
Autophagy
|
Cancer
|
Peruvoside is a potent inhibitor of Src, PI3K, JNK, STAT, and EGFR. Peruvoside induces apoptosis and autophagy and possesses a broad spectrum of anticancer activity in breast, lung, liver cancers and leukemia. Peruvoside is a broad-spectrum and potent antiviral activity against positive-sense RNA viruses. Peruvoside sensitizes Gefitinib (HY-50895)-resistant tumour cells (A549, PC9/gef and H1975) to Gefitinib .
|
-
- HY-167879A
-
|
Fungal
Fatty Acid Synthase (FASN)
|
Infection
Inflammation/Immunology
|
NPD6433 is a triazenyl indole with broad-spectrum activity against all screening fungal strains. NPD6433 targets the enoyl reductase domain of fatty acid synthase 1 (Fas1), covalently inhibiting its flavin mononucleotide-dependent NADPH-oxidation activity and arresting essential fatty acid biosynthesis .
|
-
- HY-137139
-
|
Antibiotic
Bacterial
Farnesyl Transferase
|
Infection
Cancer
|
10'-Desmethoxystreptonigrin is an inhibitor for Ras Farnesyltransferase with an IC50 of 21 μM. 10'-Desmethoxystreptonigrin is a broad-spectrum antibiotic with antibacterial activity. 10'-Desmethoxystreptonigrin exhibits antitumor activity against P388 leukemia, without significant cytotoxicity (LD50 is 8.8 mg/kg) .
|
-
- HY-B0529R
-
|
Reference Standards
Bacterial
Parasite
Antibiotic
|
Infection
|
Azlocillin (Standard) is the analytical standard of Azlocillin. This product is intended for research and analytical applications. Azlocillin, an antibiotic, is a semisynthetic penicillin, and has broad-spectrum antibacterial activity. Azlocillin is active against drug-tolerant B. burgdorferi sensu stricto JLB31 infection .
|
-
- HY-N7047
-
|
Bacterial
|
Infection
|
8-Epidiosbulbin E acetate, a furanoid, is abundant in Dioscorea bulbifera L.. 8-Epidiosbulbin E acetate exhibits broad-spectrum plasmid-curing activity against multidrug-resistant (MDR) bacteria. 8-Epidiosbulbin E acetate induces liver injury in mice .
|
-
- HY-B1354
-
SM-1652 free acid; Wy-44635 free acid
|
Beta-lactamase
Antibiotic
Bacterial
|
Infection
|
Cefpiramide (SM-1652) free acid is a semisynthetic cephalosporin with broad-spectrum antibacterial activity. Cefpiramide free acid shows strong antibacterial effect on both gram-positive bacteria and gram-negative bacteria. Cefpiramide free acid is moderately susceptible to β-lactamase .
|
-
- HY-126662
-
|
Antibiotic
Bacterial
|
Infection
|
Netzahualcoyone is a triterpenoid compound isolated from the Celastraceae plant family. Netzahualcoyone exhibits broad-spectrum antibiotic activity against Gram-positive bacteria and yeasts, but is not active against Gram-negative bacteria. Netzahualcoyone can be utilized in the development of antibiotics and for studying antimicrobial mechanisms .
|
-
- HY-147654
-
|
PROTACs
Influenza Virus
|
Infection
|
PROTAC Hemagglutinin Degrader-1 (Compound V3) is a potent PROTAC influenza hemagglutinin (HA) degrader with a median degradation concentration of 1.44 μM. PROTAC Hemagglutinin Degrader-1 shows broad-spectrum anti-influenza virus activity .
|
-
- HY-B0455AR
-
SC47111A (Standard); NY-198 (Standard)
|
Reference Standards
Bacterial
Antibiotic
|
Infection
|
Lomefloxacin (Standard) is the analytical standard of Lomefloxacin. This product is intended for research and analytical applications. Lomefloxacin (SC47111A) is a broad-spectrum quinolone antibiotic, with antimicrobial activity. Lomefloxacin is used for the research of respiratory tract infections, genitourinary infections, gastrointestinal infections, ENT infections, etc. .
|
-
- HY-B0841R
-
|
Reference Standards
Cholinesterase (ChE)
|
Neurological Disease
|
Acephate (Standard) is the analytical standard of Acephate. This product is intended for research and analytical applications. Acephate is a broad-spectrum anticholinesterase insecticide. Acephate acts via inhibiting AChE (Cholinesterase (ChE)) activity of insects. Acephate is used for control of several species of insects in agriculture and in horticulture .
|
-
- HY-B1908R
-
SF-837 (Standard); Antibiotic SF-837 (Standard)
|
Reference Standards
Bacterial
Antibiotic
|
Infection
|
Lomefloxacin (Standard) is the analytical standard of Lomefloxacin. This product is intended for research and analytical applications. Lomefloxacin (SC47111A) is a broad-spectrum quinolone antibiotic, with antimicrobial activity. Lomefloxacin is used for the research of respiratory tract infections, genitourinary infections, gastrointestinal infections, ENT infections, etc. .
|
-
- HY-B0159A
-
Q-35 dihydrate
|
Bacterial
Antibiotic
|
Infection
|
Balofloxacin dihydrate (Q-35 dihydrate) is an orally active fluoroquinolone antibiotic with broad-spectrum antibacterial activity against gram-negative, gram-positive, and anaerobic bacteria. Balofloxacin dihydrate can be used for the research of respiratory, intestinal, and urinary tract infections .
|
-
- HY-16957
-
|
HCV
HIV
|
Infection
|
LJ001 is a broad-spectrum and orally active antiviral agent. LJ001 exerts antiviral activities by binding to viral membranes. LJ001 inhibits TGEV and PDCoV infection. LJ001 decreases TGEV N and PDCoV N-protein expression .
|
-
- HY-B0187AR
-
S 4661 monohydrate (Standard)
|
Reference Standards
Bacterial
Antibiotic
|
Infection
|
Doripenem (monohydrate) (Standard) is the analytical standard of Doripenem (monohydrate). This product is intended for research and analytical applications. Doripenem (S 4661) monohydrate, a 1β-methyl parenteral carbapenem, has very broad-spectrum activity against Gram-positive and Gram-negative aerobic bacteria .
|
-
- HY-155702
-
|
Fungal
|
Infection
|
Antifungal agent 66 (compound 10) has antifungal activity. Antifungal agent 66 has a broad-spectrum antifungal activity against seven phytopathogenic fungal mycelia. Antifungal agent 66 has pronounced inhibitory activity against the spore of B. cinerea with an IC50 value of 47.7 μg/mL .
|
-
- HY-A0294S
-
MK-0826-d4
|
Isotope-Labeled Compounds
Bacterial
Antibiotic
|
Infection
Cancer
|
Ertapenem-d4 (MK-0826-d4) is deuterium labeled Ertapenem. Ertapenem (MK-0826) is a broad spectrum and long acting β-lactam antibiotic. Ertapenem has a broad-spectrum anti-anaerobic activity against a variety of anaerobes with a mode MIC of 0.12 μg/mL. Ertapenem can be used for the research of severe infections caused by bacteria in the skin, lungs, stomach, pelvis, and urinary tract .
|
-
- HY-A0294AR
-
MK-0826 disodium (Standard)
|
Reference Standards
Bacterial
Antibiotic
|
Infection
Cancer
|
Ertapenem (disodium) (Standard) is the analytical standard of Ertapenem (disodium). This product is intended for research and analytical applications. Ertapenem (MK-0826) disodium is a broad spectrum and long acting β-lactam antibiotic. Ertapenem disodium has a broad-spectrum anti-anaerobic activity against a variety of anaerobes with a mode MIC of 0.12 μg/mL. Ertapenem disodium can be used for the research of severe infections caused by bacteria in the skin, lungs, stomach, pelvis, and urinary tract[1][2].
|
-
- HY-176545
-
|
HDAC
Sirtuin
|
Others
|
Z-MAL is a highly efficient and broad-spectrum HDAC substrate. Z-MAL exhibits high conversion activity for class I, II histone deacetylases, and class III SIRT1. Z-MAL can be used in studies on the structure-activity relationship, subtype selectivity, and inhibitor screening of HDAC .
|
-
- HY-N0565S3
-
-
- HY-159809
-
|
Bacterial
|
Infection
Inflammation/Immunology
|
Antibacterial agent 249 demonstrates broad-spectrum antimicrobial properties, effectively inhibiting the growth of Aspergillus niger, Bacillus subtilis, Pseudomonas albicans, Escherichia coli, and Staphylococcus aureus, while also exhibiting anti-inflammatory activity in vitro, making it a potential candidate for treating bacterial infections.
|
-
- HY-W392026
-
PHMGH
|
Antibiotic
Bacterial
Fungal
|
Infection
|
Polyhexamethyleneguanidine (PHMGH) hydrochloride is a positively charged polymer with broad-spectrum antimicrobial activity. It exerts its antibacterial effects by binding to the cell membranes of bacteria and fungi, disrupting membrane integrity. Polyhexamethyleneguanidine hydrochloride can be applied in studies related to disinfection, water treatment, pesticides, and other fields [2]
|
-
- HY-B1464
-
|
Bacterial
HBV
|
Infection
Inflammation/Immunology
|
Cetylpyridinium chloride, a cationic quaternary ammonium compound, is an anti-bacterial agent with broad-spectrum activity. Cetylpyridinium chloride is an effective anti-HBV capsid assembly inhibitor with an IC50 of 2.5 μM. Cetylpyridinium chloride is used in pesticides and various types of mouthwashes, and other personal care products .
|
-
- HY-A0088S
-
Cefotaxim-d3 sodium; HR-756-d3 sodium
|
Isotope-Labeled Compounds
Beta-lactamase
Bacterial
Antibiotic
|
Infection
|
Cefotaxime-d3 (sodium) is the deuterium labeled Cefotaxime (sodium salt). Cefotaxime sodium salt, a β-lactamase stable cephalosporin and a third-generation cephalosporin antibiotic, possesses broad-spectrum antibiotic activity against numerous Gram-positive and Gram-negative bacteria .
|
-
- HY-B1444R
-
|
Reference Standards
Bacterial
Fungal
Antibiotic
|
Infection
|
Isoconazole (nitrate) (Standard) is the analytical standard of Isoconazole (nitrate). This product is intended for research and analytical applications. Isoconazole nitrate is a broad-spectrum antimicrobial agent with a highly effective antimycotic and gram-positive antibacterial activity, exhibiting a rapid rate of absorption and low systemic exposure potential .
|
-
- HY-122008
-
|
Bacterial
|
Infection
|
Levonadifloxacin ((S)-(-)-Nadifloxacin; WCK 771) arginine is a broad-spectrum antistaphylococcal agent. Levonadifloxacin arginine has antimicrobial activity against methicillin-susceptible Staphylococcus aureus (MSSA) and methicillin-resistant Staphylococcus aureus and reduces phagocytosis of MRSA and MSSA strains by monocytic THP-1.
|
-
- HY-161454
-
|
Virus Protease
Influenza Virus
SARS-CoV
|
Infection
|
Antiviral agent 54 (compound 33) is a broad-spectrum and orally active antiviral agent. Antiviral agent 54 shows antiviral activity for ZIKV, HCoV-OC43 and influenza A virus (IVA). Antiviral agent 54 decreases the ZIKV RNA and protein level .
|
-
- HY-136063
-
|
Fungal
Cytochrome P450
|
Infection
|
Mefentrifluconazole is a novel azole derivative and used as an agrochemical broad-spectrum antifungal agent. Mefentrifluconazole is a potent, selective and orally active fungal CYP51 (Kd= 0.5 nM) inhibitor, but shows less inhibitory activity on human aromatase (IC50=0.92 μM) .
|
-
- HY-12824
-
|
Antibiotic
Bacterial
|
Infection
|
RNPA1000, an antibiotic, is a potent RnpA inhibitor and inhibits RnpA-mediated cellular RNA degradation. RNPA1000 inhibits tRNA maturation with an IC50 of 175 μM. RNPA1000 displays broad-spectrum antimicrobial activities and inhibits staphylococcal and all Gram-positive bacterial pathogens activity .
|
-
- HY-A0107R
-
MK-801 maleate (Standard)
|
Reference Standards
Bacterial
Antibiotic
|
Infection
Cancer
|
Tetracycline (Standard) is the analytical standard of Tetracycline. This product is intended for research and analytical applications. Tetracycline is a broad-spectrum antibiotic with oral activity. Tetracycline exhibits activity against a wide range of bacteria including gram-positive, gram-negative bacteria, chlamydiae, mycoplasmas and rickettsiae. Tetracycline can be used for the research of infections .
|
-
- HY-N0565BR
-
Doxycycline hydrochloride hemiethanolate hemihydrate (Standard); WC2031 (Standard)
|
Reference Standards
Antibiotic
MMP
Bacterial
Parasite
|
Infection
Cancer
|
Doxycycline hyclate (Standard) is the analytical standard of Doxycycline hyclate. This product is intended for research and analytical applications. Doxycycline hyclate, an antibiotic, is an orally active and broad-spectrum metalloproteinase (MMP) inhibitor . Doxycycline hyclate shows antibacterial activity and anti-cancer cell proliferation activity .
|
-
- HY-114300
-
|
GABA Receptor
|
Neurological Disease
|
DSP-0565 (compound 17a) is a strong, broad-spectrum anti-epileptic agent (AED) candidate with unique GABAergic function. DSP-0565 shows anti-convulsant activity in various models (scPTZ, MES, 6 Hz and amygdala kindling) with good safety margin .
|
-
- HY-173354
-
|
Dihydroorotate Dehydrogenase
|
Infection
|
hDHODH-IN-17 (Compound 10) is a human dihydroorotate dehydrogenase (hDHODH) inhibitor, with an IC50 of 0.188 μM. hDHODH-IN-17 is in good agreement with the hDHODH activity pocket and interacted well with amino acid residues. hDHODH-IN-17 is the potential broad-spectrum antiviral agent .
|
-
- HY-18234A
-
-
- HY-162782A
-
|
Antibiotic
Bacterial
|
Infection
|
V–C6–Bg-PhCl TFA (compound 5e) is a biguanide-vancomycin conjugate. V–C6–Bg-PhCl TFA has broad-spectrum antibacterial activity against both Gram-negative and Gram-positive bacteria .
|
-
- HY-76200
-
UK-109496
|
Fungal
Bacterial
|
Infection
Cancer
|
Voriconazole (UK-109496) is a second-generation, broad-spectrum triazole antifungal agent that inhibits fungal ergosterol biosynthesis. Voriconazole exerts its antifungal activity by inhibition of 14-α-lanosterol demethylation, which is mediated by fungal cytochrome P450 enzymes .
|
-
- HY-N7112
-
Kitasamycin
|
Bacterial
Antibiotic
|
Infection
|
Leucomycin (Kitasamycin) is an orally active macrolide antibiotic produced by Streptomyces kitasatoensis. Leucomycin has broad-spectrum antibacterial activities against gram-positive and gram-negative bacteria, mycoplasma, leptospira, spirochaetes, rickettsiae and some larger viruses .
|
-
- HY-P2170
-
XOMA-629
|
Antibiotic
Bacterial
|
Infection
Inflammation/Immunology
|
XMP-629 (XOMA-629), a cationic α-helical peptide, is a potent endotoxin inhibitor. XMP-629 exhibits broad-spectrum antimicrobial activity via an immunomodulatory mechanism. XOMA 629 has antimicrobial activity against Propionibacterium acnes, Staphylococcus aureus and Streptococcus pyogenesand .
|
-
- HY-149323
-
|
Fungal
|
Infection
|
SDH-IN-4 (compound B6) is a selective inhibitor against succinate dehydrogenase (SDH) with an IC50 value of 0.28 μg/mL. SDH-IN-4 has highly efficient and broad-spectrum antifungal activity, against R. solani with an EC50 value of 0.23 μg/mL .
|
-
- HY-P99490
-
hzVSF-v13
|
Interleukin Related
SARS-CoV
|
Infection
Inflammation/Immunology
|
Burfiralimab (hzVSF-v13) is a monoclonal IgG4 antibody against vimentin expressed on the surface of virus-infected cells, with broad-spectrum antiviral activity and anti-inflammatory effects against virus-induced inflammation. Burfiralimab can be used in severe COVID-19 studies .
|
-
- HY-N7096R
-
CTZ sodium (Standard)
|
Reference Standards
Bacterial
Antibiotic
|
Infection
|
Ceftezole (sodium) (Standard) is the analytical standard of Ceftezole (sodium). This product is intended for research and analytical applications. Ceftezole sodium (CTZ sodium) is a broad-spectrum cephem antibiotic against many species of gram-positive and gram-negative bacteria. Ceftezole sodium (CTZ sodium) is an alpha-glucosidase inhibitor with in vivo anti-diabetic activity .
|
-
- HY-14926B
-
(S)-(-)-Nadifloxacin arginine; WCK 771 arginine
|
Bacterial
|
Infection
|
Levonadifloxacin ((S)-(-)-Nadifloxacin; WCK 771) arginine is a broad-spectrum antistaphylococcal agent. Levonadifloxacin arginine has antimicrobial activity against methicillin-sensitive Staphylococcus aureus (MSSA) and methicillin-resistant Staphylococcus aureus and reduces phagocytosis of MRSA and MSSA strains by monocytic THP-1 cells .
|
-
- HY-116214
-
-
- HY-101399R
-
γ-Glutamylphenylalanine (Standard)
|
Reference Standards
Endogenous Metabolite
|
Others
|
Ceftezole (sodium) (Standard) is the analytical standard of Ceftezole (sodium). This product is intended for research and analytical applications. Ceftezole sodium (CTZ sodium) is a broad-spectrum cephem antibiotic against many species of gram-positive and gram-negative bacteria. Ceftezole sodium (CTZ sodium) is an alpha-glucosidase inhibitor with in vivo anti-diabetic activity .
|
-
- HY-B0834R
-
(RS)-Indoxacarb (Standard); DPX-JW062 (Standard)
|
Reference Standards
Sodium Channel
|
Neurological Disease
|
(±)-Indoxacarb (Standard) is the analytical standard of Indoxacarb. This product is intended for research and analytical applications. Indoxacarb ((±)-Indoxacarb; DPX-JW062) is a broad-spectrum oxadiazine insecticide with high insecticidal activity and low mammalian toxicity. Indoxacarb blocks insect sodium channels (Sodium Channel) in nerve preparations and isolated neurons .
|
-
- HY-12155
-
|
Sodium Channel
Calcium Channel
|
Neurological Disease
|
JNJ-26990990 is a broad-spectrum antiepileptic agent with oral activity. JNJ-26990990 can inhibit voltage-gated Na + channels and N-type Ca 2+ channels, but has a very weak inhibitory effect on human carbonic anhydrase-II (IC50 = 110 μM) .
|
-
- HY-14926A
-
(S)-(-)-Nadifloxacin (arginine) hydrate; WCK-771A (arginine) hydrate
|
Antibiotic
Bacterial
|
Infection
|
Levonadifloxacin (arginine) hydrate is a broad-spectrum anti-staphylococcal agent. Levonadifloxacin (arginine) hydrate shows antibacterial activity against Methicillin (HY-121544)-susceptible Staphylococcus aureus (MSSA) and Methicillin-resistant S. aureus (MRSA) strains, with a reduction of which phagocytized in THP-1 monocytes .
|
-
- HY-163634
-
|
Fungal
|
Infection
|
YZK-C22, containing a 1,2,3-thiadiazol-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole skeleton, is a fungicide lead compound with broad-spectrum fungicidal activity .
|
-
- HY-159955
-
|
Bacterial
|
Infection
|
DC-159a is an 8-methoxyfluoroquinolone with broad-spectrum antimicrobial activity, especially against Gram-positive pathogens. DC-159a against Peptostreptococcus, Clostridium difficile, and Bacteroides fragilis with MIC90 values of 0.5, 4, and 2 μg/mL, respectively .
|
-
- HY-157990
-
|
Wnt
β-catenin
|
Cancer
|
Wnt/β-catenin-in-1 (compounds 17) is a Wnt/β-catenin signaling pathway inhibitor. Wnt/β-catenin-IN-1 can induce apoptosis of colon cancer cells, has broad-spectrum anticancer activity, and can be used for the reseach of a variety of solid tumors .
|
-
- HY-138540
-
N-Dodecylimidazole
|
Fungal
|
Cancer
|
1-Dodecylimidazole (N-Dodecylimidazole) is a lysosomotropic detergent and a cytotoxic agent. 1-Dodecylimidazole causes cell death by its acid-dependent accumulation in lysosomes, disruption of the lysosomal membrane, and releaseof cysteine proteases into the cytoplasm. 1-Dodecylimidazole has hypocholesterolaemic activity and broad-spectrum antifungal activity .
|
-
- HY-12643S
-
MK-397-d3
|
Isotope-Labeled Compounds
|
Infection
Cancer
|
Eprinomectin-d3 (MK-397-d3) is the deuterium-labeled Eprinomectin (HY-12643). Eprinomectin is a type of avermectin. Eprinomectin,as a broad-spectrum fungicide,has insecticidal,insecticidal and acaricidal activities. Eprinomectin induces apoptosis and autophagy in prostate cancer cells and has antitumor activity .
|
-
- HY-128423A
-
Acetylisovaleryltylosin
|
Antibiotic
Bacterial
NF-κB
Apoptosis
|
Infection
Inflammation/Immunology
Cancer
|
Tylvalosin (Acetylisovaleryltylo?sin) is an orally active, broad-spectrum macrolide antibiotic with antimicrobial activity. Tylvalosin is an antiviral agent used to study PRRSV infection. Tylvalosin induces apoptosis. Tylvalosin also has anti-inflammatory activity, alleviates oxidative stress, and alleviates acute lung injury by inhibiting NF-κB activation .
|
-
- HY-A0107S2
-
|
Antibiotic
Bacterial
Isotope-Labeled Compounds
|
Infection
|
Tetracycline-d6-1 is deuterated labeled Tetracycline (HY-A0107). Tetracycline is a broad-spectrum antibiotic with oral activity. Tetracycline exhibits activity against a wide range of bacteria including gram-positive, gram-negative bacteria, chlamydiae, mycoplasmas and rickettsiae. Tetracycline can be used for the research of infections .
|
-
- HY-147730
-
|
HDAC
|
Cancer
|
A variety of compounds were designed and synthesized by modifying cap groups. The enzyme inhibition test showed that compound 12C had broad-spectrum enzyme inhibitory activity, and compounds 9m and 9q were more inclined to inhibit HDAC6, showing a certain selective inhibitory activity among the representative subtypes.
|
-
- HY-12638
-
DDM
|
Bacterial
Fungal
Parasite
|
Infection
|
Dichlorophen is a chlorophenol antimicrobial agent that can destroy the integrity of microbial cell membranes and interfere with the activity of metabolic enzymes. Dichlorophen can covalently bind to the thiol groups of microbial proteins and has broad-spectrum antibacterial, antifungal and anthelmintic activity. Dichlorophen can be used as an antimicrobial agent in the study of drug-resistant bacterial infections .
|
-
- HY-N0168AS1
-
-
- HY-116617R
-
15-Keto Fluprostenol isopropyl ester (Standard)
|
Drug Metabolite
Reference Standards
|
Others
|
Cefotaxime (Standard) is the analytical standard of Cefotaxime. This product is intended for research and analytical applications. Cefotaxime, a β-lactamase stable cephalosporin and a third-generation cephalosporin antibiotic, possesses broad-spectrum antibiotic activity against numerous Gram-positive and Gram-negative bacteria .
|
-
- HY-A0088AR
-
Cefotaxim (Standard); HR-756 (Standard)
|
Beta-lactamase
Reference Standards
Bacterial
Antibiotic
|
Infection
Inflammation/Immunology
|
Cefotaxime (Standard) is the analytical standard of Cefotaxime. This product is intended for research and analytical applications. Cefotaxime, a β-lactamase stable cephalosporin and a third-generation cephalosporin antibiotic, possesses broad-spectrum antibiotic activity against numerous Gram-positive and Gram-negative bacteria .
|
-
- HY-18649B
-
BCX4430 dihydrochloride; Immucillin-A dihydrochloride
|
Flavivirus
|
Infection
|
Galidesivir (BCX4430; Immucillin-A) dihydrochloride is a broad-spectrum RNA virus inhibitor that can inhibit Ebola and yellow fever virus (Flavivirus) infections. Galidesivir has potent antiviral activity against tick-borne encephalitis virus (TBEV) and also inhibits the proliferation of many other medically important flaviviruses .
|
-
- HY-161144
-
|
Akt
Apoptosis
|
Cancer
|
AKT-IN-21 (compound C36) is a potent AKT inhibitor with broad-spectrum cytotoxicity and anticancer activity. AKT-IN-21 also blocks the cell cycle and induces apoptosis of cancer cells by down-regulating the PI3K/AKT pathway .
|
-
- HY-14956
-
TG-873870
|
Antibiotic
Bacterial
|
Infection
Inflammation/Immunology
|
Nemonoxacin (TG-873870) is an orally active and potent broad-spectrum antibiotic. Nemonoxacin shows good inhibitory activity against different species of staphylococci, streptococci, and enterococci, Neisseria gonorrhoeae, and Haemophilus influenza. Nemonoxacin can be used in the study of bacterial infections and community-acquired pneumonia .
|
-
- HY-127054
-
Sch 20569
|
Antibiotic
Bacterial
|
Infection
|
Netilmicin (Sch 20569) is a broad-spectrum semisynthetic aminoglycoside antibiotic. Netilmicin exhibits antibacterial activity against aminoglycoside-susceptible gram-negative strains and aminoglycoside-resistant strain, such as Escherichia coli, Pseudomonas aeruginosa, Proteus, Staphylococcus aureus, Streptococcus, Serratia, and Enterobacter, with MIC of 0.125-8 μg/mL .
|
-
- HY-76200B
-
UK-109496 camphorsulfonate
|
Fungal
Bacterial
|
Infection
Cancer
|
Voriconazole (UK-109496) camphorsulfonate is a second-generation, broad-spectrum triazole antifungal agent that inhibits fungal ergosterol biosynthesis. Voriconazole camphorsulfonate exerts its antifungal activity by inhibition of 14-α-lanosterol demethylation, which is mediated by fungal cytochrome P450 enzymes .
|
-
- HY-A0088R
-
Cefotaxim sodium (Standard); HR-756 sodium (Standard)
|
Beta-lactamase
Reference Standards
Bacterial
Antibiotic
|
Infection
|
Cefotaxime (sodium) (Standard) is the analytical standard of Cefotaxime (sodium). This product is intended for research and analytical applications. Cefotaxime (Cefotaxim) sodium, a β-lactamase stable cephalosporin and a third-generation cephalosporin antibiotic, possesses broad-spectrum antibiotic activity against numerous Gram-positive and Gram-negative bacteria .
|
-
- HY-B0239S3
-
|
Isotope-Labeled Compounds
Bacterial
Antibiotic
|
Infection
|
Chloramphenicol-d4 is deuterium labeled Chloramphenicol. Chloramphenicol, a broad-spectrum antibiotic, acts as a potent inhibitor of bacterial protein biosynthesis . Chloramphenicol acts primarily on the 50S subunit of bacterial 70S rihosomes and inhibits peptide bond formation by suppressing peptidyl transferase activity .
|
-
- HY-14926
-
(S)-(-)-Nadifloxacin; WCK 771
|
Antibiotic
Bacterial
|
Infection
|
Levonadifloxacin ((S)-(-)-Nadifloxacin; WCK 771) is a broad-spectrum anti-staphylococcal agent. Levonadifloxacin shows antibacterial activity against Methicillin (HY-121544)-susceptible Staphylococcus aureus (MSSA) and Methicillin-resistant S. aureus (MRSA) strains, with a reduction of which phagocytized in THP-1 monocytes .
|
-
- HY-105284
-
CP-70429
|
Beta-lactamase
Bacterial
Antibiotic
|
Infection
|
Sulopenem (CP-70429) is an orally active, parenteral penem antibiotic with broad-spectrum activities against Gram-positive and Gram-negative bacteria. Sulopenem has the potential for urinary tract infections and intra-abdominal infections treatment. Sulopenem is inactive against Pseudomonas aeruginosa and Xanthomonas maltophilia .
|
-
- HY-B0122
-
-
- HY-14283R
-
NND 502 (Standard)
|
Reference Standards
Fungal
Antibiotic
|
Infection
|
Luliconazole (Standard) is the analytical standard of Luliconazole. This product is intended for research and analytical applications. Luliconazole (NND 502) is a topical antifungal imidazole antibiotic with broad-spectrum and potent antifungal activity. Luliconazole can be used for the research of skin infection, including dermatophytosis, tinea corporis, tinea pedis et al .
|
-
- HY-163459
-
|
Fungal
|
Infection
|
HWY-289 is a semisynthetic protoberberine derivative, has broad-spectrum and potent activities against phytopathogenic fungi, particularly Botrytis cinerea (EC50 = 1.34 μg/mL). HWY-289 changes the morphology of the mycelium and the internal structure of cells. HWY-289 reduces ATP content, ATPase activities, and key enzyme activities in the TCA cycle .
|
-
- HY-151421
-
|
Fungal
|
Infection
Cancer
|
Chitin synthase inhibitor 11 is a chitin synthase inhibitor. Chitin synthase inhibitor 11 shows excellent chitin synthase inhibitory activity with an IC50 value of 0.10 mM. Chitin synthase inhibitor 11 has broad-spectrum antifungal activity in vitro. Chitin synthase inhibitor 11 can be used for the research of invasive fungal infections (IFIs) .
|
-
- HY-167879
-
|
Fungal
Fatty Acid Synthase (FASN)
|
Infection
Inflammation/Immunology
|
(Rac)-NPD6433 is a racemate of NPD6433. NPD6433 is a triazenyl indole with broad-spectrum activity against all screening fungal strains. NPD6433 targets the enoyl reductase domain of fatty acid synthase 1 (Fas1), covalently inhibiting its flavin mononucleotide-dependent NADPH-oxidation activity and arresting essential fatty acid biosynthesis .
|
-
- HY-14904A
-
|
Influenza Virus
SARS-CoV
CHIKV
|
Infection
|
Umifenovir hydrochloride is a potent, orally active broad-spectrum antiviral with activity against a number of enveloped and non-enveloped viruses. Umifenovir hydrochloride is used as an anti-influenza virus agent. Umifenovir hydrochloride could effectively inhibit the fusion of virus with host cells . Umifenovir hydrochloride is an efficient inhibitor of SARS-CoV-2 in vitro. Anti-inflammatory activity .
|
-
- HY-W740053
-
|
Penicillin-binding protein (PBP)
Bacterial
Antibiotic
|
Infection
Cancer
|
Meropenem sodium is a carbapenem antibiotic with broad-spectrum antibacterial activity. Meropenem sodium has activity against susceptible and resistant N. gonorrhoeae (MIC value of 0.02-0.06 mg/mL), H. influenzae (MIC value of 0.03-0.12 mg/mL), and H. ducreyi (MIC value of 0.015-0.12 mg/mL) .
|
-
- HY-W654101
-
Cefotaxim-d3; HR-756-d3
|
Isotope-Labeled Compounds
Antibiotic
Bacterial
|
Infection
|
Cefotaxime-d3 is the deuterium labeled Cefotaxime (HY-A0088A). Cefotaxime is the β-lactamase stable cephalosporin and the third-generation cephalosporin antibiotic. Cefotaxime possesses broad-spectrum antibiotic activity against numerous Gram-positive and Gram-negative bacteria .
|
-
- HY-151416
-
|
Fungal
|
Infection
|
Chitin synthase inhibitor 6 (compound 9b) is a potent chitin synthase (CHS) inhibitor with an IC50 value of 0.21 mM. Chitin synthase inhibitor 6 has broad-spectrum antifungal activity against drug-resistant fungi. Chitin synthase inhibitor 6 can be used in the research of fungi infection .
|
-
- HY-105284A
-
CP-70429 sodium
|
Bacterial
Antibiotic
|
Inflammation/Immunology
|
Sulopenem (sodium)(CP-70429 (sodium)) is an orally active, parenteral penem antibiotic with broad-spectrum activities against Gram-positive and Gram-negative bacteria. Sulopenem has the potential for urinary tract infections and intra-abdominal infections treatment. Sulopenem is inactive against Pseudomonas aeruginosa and Xanthomonas maltophilia .
|
-
- HY-A0086
-
SCH-20569 sulfate
|
Bacterial
Antibiotic
|
Infection
|
Netilmicin (Sch 20569) sulfate is a broad-spectrum semisynthetic aminoglycoside antibiotic. Netilmicin sulfate exhibits antibacterial activity against aminoglycoside-susceptible gram-negative strains and aminoglycoside-resistant strain, such as Escherichia coli, Pseudomonas aeruginosa, Proteus, Staphylococcus aureus, Streptococcus, Serratia, and Enterobacter, with MIC of 0.125-8 μg/mL .
|
-
- HY-W250302
-
|
Biochemical Assay Reagents
|
Others
|
Methylbenzethonium chloride is a quaternary ammonium compound commonly used as a preservative and disinfectant in a variety of personal care and healthcare products. Methylbenzethonium chloride has several properties that make it suitable for these applications, including its broad-spectrum antibacterial activity against bacteria, viruses and fungi. In addition, it is used as a preservative in cosmetic and pharmaceutical formulations to prevent the growth of microorganisms.
|
-
- HY-151417
-
|
Fungal
|
Infection
|
Chitin synthase inhibitor 7 (compound 9c) is a potent chitin synthase (CHS) inhibitor with an IC50 value of 0.37 mM. Chitin synthase inhibitor 7 has broad-spectrum antifungal activity against drug-resistant fungi. Chitin synthase inhibitor 7 can be used in the research of fungi infection .
|
-
- HY-B1286
-
Sodium piperacillin
|
Bacterial
Antibiotic
Penicillin-binding protein (PBP)
|
Infection
Cancer
|
Piperacillin sodium is a semisynthetic broad-spectrum β-lactam antibiotic which exhibits potent bactericidal activity against Gram-negative bacteria as well as select Gram-positive strains through penicillin-binding proteins. Piperacillin is most commonly used in combination with the β-lactamase inhibitor Tazobactam .
|
-
- HY-N6625
-
|
Fungal
Estrogen Receptor/ERR
|
Infection
|
Chlorothalonil is a broad-spectrum foliar fungicide with oral activity. Chlorothalonil can be used to combat fungal diseases in vegetable and crop leaves. Chlorothalonil can alter the microbial community in the soil. Chlorothalonil inhibits spermatogenesis. Chlorothalonil can cause intestinal epithelial barrier dysfunction and fetal toxicity .
|
-
- HY-B1923
-
Pipracil
|
Antibiotic
Bacterial
Beta-lactamase
Penicillin-binding protein (PBP)
|
Infection
Cancer
|
Piperacillin is a semisynthetic broad-spectrum β-lactam antibiotic which exhibits potent bactericidal activity against Gram-negative bacteria as well as select Gram-positive strains through penicillin-binding proteins. Piperacillin is most commonly used in combination with the β-lactamase inhibitor Tazobactam .
|
-
- HY-B0458AS
-
|
Isotope-Labeled Compounds
Bacterial
Antibiotic
|
Infection
|
Cefprozil-d4 is the deuterium labeled Cefprozi (HY-B0458A) . Cefprozil is a second-generation cephalosporin type antibiotic. Cefprozil exhibits broad-spectrum antibacterial activity, and is orally active. Cefprozil can be used for the study of pharyngitis, tonsillitis, otitis media, and uncomplicated skin infections .
|
-
- HY-B1064A
-
Clindamycin 2-phosphate hydrochloride; U-28508 hydrochloride
|
Bacterial
Antibiotic
Parasite
|
Infection
Cancer
|
Clindamycin phosphate (Clindamycin 2-phosphate) hydrochloride is a broad-spectrum bacteriostatic lincosamide antibiotic. Clindamycin phosphate hydrochloride is the proagent of Clindamycin (HY-B1455) with no antimicrobial activity in vitro but can be rapidly converted in vivo to the active parent agent, Clindamycin, by phosphatase ester hydrolysis. Clindamycin phosphate hydrochloride can be used for researching acne and bacterial vaginosis .
|
-
- HY-159688
-
|
Bacterial
|
Infection
|
Cefditoren is an orally active antibiotic with broad-spectrum antibacterial activity, capable of inhibiting both Gram-negative and Gram-positive bacteria. It has a MIC50 of 0.25-0.5 mg/L against Streptococcus pneumoniae strains. Cefditoren is effective against respiratory tract infections and skin infections .
|
-
- HY-B0122A
-
McN 4853 lithium; RWJ 17021 lithium
|
iGluR
GABA Receptor
Sodium Channel
Calcium Channel
Potassium Channel
Carbonic Anhydrase
|
Neurological Disease
|
Topiramate (McN 4853) lithium is a broad-spectrum antiepileptic agent. Topiramate lithium is a GluR5 receptor antagonist. Topiramate produces its antiepileptic effects through enhancement of GABAergic activity, inhibition of kainate/AMPA receptors, inhibition of voltage-sensitive sodium and calcium channels, increases in potassium conductance, and inhibition of carbonic anhydrase .
|
-
- HY-W774918R
-
|
Fungal
Reference Standards
|
|
Oxaziclomefone (Standard) is the analytical standard of Oxaziclomefone. This product is intended for research and analytical applications. Oxaziclomefone is a broad-spectrum pesticide with fungal activity. Oxaziclomefone effectively controls a variety of crop diseases and has significant effects against plant pathogenic fungi. Oxaziclomefone is widely used in agriculture to protect crops from diseases and improve crop yield and quality.
|
-
- HY-B0159R
-
Q-35 (Standard)
|
Reference Standards
Bacterial
Antibiotic
|
Infection
|
Balofloxacin (Standard) is the analytical standard of Balofloxacin. This product is intended for research and analytical applications. Balofloxacin (Q-35) is an orally active fluoroquinolone antibiotic with broad-spectrum antibacterial activity against gram-negative, gram-positive, and anaerobic bacteria. Balofloxacin can be used for the research of respiratory, intestinal, and urinary tract infections .
|
-
- HY-N2949
-
|
SARS-CoV
|
Infection
Cancer
|
Bonducellpin D is a furanoditerpenoid lactone isolated from Caesalpinia minax. Bonducellpin D exhibits broad-spectrum inhibition potential against SARS-CoV M pro and MERS-CoV M pro, with an Ki of 467.11 and 284.86 nM, respectively. Bonducellpin D also exhibits moderate anti-cancer activity in vitro .
|
-
- HY-112101R
-
n-Propyl dihydrojasmonate (Standard)
|
Drug Isomer
Reference Standards
|
Others
|
Oxaziclomefone (Standard) is the analytical standard of Oxaziclomefone. This product is intended for research and analytical applications. Oxaziclomefone is a broad-spectrum pesticide with fungal activity. Oxaziclomefone effectively controls a variety of crop diseases and has significant effects against plant pathogenic fungi. Oxaziclomefone is widely used in agriculture to protect crops from diseases and improve crop yield and quality.
|
-
- HY-14283S1
-
NND 502-d3
|
Isotope-Labeled Compounds
Antibiotic
Fungal
|
Infection
|
Luliconazole-d3 (NND 502-d3) is deuterium labeled Luliconazole. Luliconazole (NND 502)?is a topical antifungal imidazole antibiotic with broad-spectrum and potent antifungal activity. Luliconazole can be used for the research of skin infection, including?dermatophytosis, tinea corporis, tinea pedis?et al .
|
-
- HY-N12697A
-
|
SARS-CoV
Virus Protease
Influenza Virus
Fungal
|
Infection
|
Polycarpine hydrochloride (1a) is a broad-spectrum Mpro inhibitor (IC50 = 30 nM) that can be isolated from the Polycarpa aurata and also serves as an anti-coronaviral agent. Polycarpine hydrochloride possesses antiviral and antifungal activities, with IC50 values of 30.0 nM and 0.12 μM against SARS-CoV-2 Mpro and PEDV Mpro, respectively .
|
-
- HY-B0536A
-
AM 1091 hydrochloride; CI 960 hydrochloride; PD127391 hydrochloride
|
Bacterial
Antibiotic
|
Infection
|
Clinafloxacin hydrochloride (AM 1091 hydrochloride) is a potent and broad-spectrum fluoroquinolone antibiotic, has inhibitory activity against gram-positive, gram-negative bacterias, and anaerobic pathogens in vitro . Clinafloxacin hydrochloride is against DNA gyrase and topoisomerase IV of S. aureus with IC50 values of 0.92 µg/ml and 1.62 µg/ml, respectively .
|
-
- HY-B0536
-
AM-1091; CI-960; PD 127391
|
Bacterial
Antibiotic
|
Infection
|
Clinafloxacin (AM 1091) is a potent and broad-spectrum fluoroquinolone antibiotic, has inhibitory activity against gram-positive, gram-negative bacterias, and anaerobic pathogens in vitro . Clinafloxacin is against DNA gyrase and topoisomerase IV of?S. aureus with IC50 values of 0.92 μg/ml and 1.62 μg/ml, respectively .
|
-
- HY-B0458R
-
|
Reference Standards
Antibiotic
Bacterial
|
Infection
|
Cefprozil monohydrate (Standard) is the analytical standard of Cefprozil monohydrate (HY-B0458). This product is intended for research and analytical applications. Cefprozil monohydrate is a second-generation cephalosporin type antibiotic. Cefprozil monohydrate exhibits broad-spectrum antibacterial activity, and is orally active. Cefprozil monohydrate can be used for the study of pharyngitis, tonsillitis, otitis media, and uncomplicated skin infections .
|
-
- HY-123024
-
BL-S-640; SK&F 60771
|
Apoptosis
Bacterial
Antibiotic
|
Infection
Cancer
|
Cefatrizine (BL-S-640) is an orally active and broad-spectrum cephalosporin antibiotic. Cefatrizine is also a eEF2K inhibitor, with anti-proliferative activity in human breast cancer cells, which could induce ER stress, leading to cell death. Cefatrizine can be used in studies of cancer and bacterial infection .
|
-
- HY-14283S
-
NND 502-13C7
|
Isotope-Labeled Compounds
|
Infection
|
Luliconazole- 13C7 (NND 502- 13C7) is 13C labeled Luliconazole. Luliconazole (NND 502)?is a topical antifungal imidazole antibiotic with broad-spectrum and potent antifungal activity. Luliconazole can be used for the research of skin infection, including?dermatophytosis, tinea corporis, tinea pedis?et al .
|
-
- HY-168108
-
|
Fungal
|
Infection
|
Antifungal agent 115 (compound 8n) is a non-competitive chitin synthase (CHS) inhibitor with an IC50 of 93 μM. Antifungal agent 115 demonstrates good selectivity and broad-spectrum antifungal activity, exhibiting significant efficacy against drug-resistant fungi. Antifungal agent 115 can be utilized in fungi infection research .
|
-
- HY-108307
-
Gentamicin C2b sulfate; Antibiotic XK-62-2 sulfate; Sagamicin sulfate
|
Antibiotic
Bacterial
|
Infection
|
Micronomicin sulfate (Gentamicin C2b sulfate) is an aminoglycoside antibiotic isolated from Micromonospora. Micronomicin sulfate is a broad-spectrum antibiotic close to the gentamicin-type antibiotics, exhibits a high activity against Pseudomonas, Proteus, Klebsiella pneumoniae, Serratia, etc (MIC=0.001-8.3 μg/ml) .
|
-
- HY-151410
-
|
Fungal
|
Infection
|
Chitin synthase inhibitor 5 (compound 9a) is an inhibitor of chitin synthase with an IC50 value of 0.14 mM. Chitin synthase inhibitor 5 shows broad-spectrum antifungal activity in vitro and shows good inhibition to C. albicans, A. flavus, A. fumigatus and C. neoformans. Chitin synthase inhibitor 5 can be used for the research of fungal .
|
-
- HY-B0778
-
|
Antibiotic
Parasite
|
Infection
|
Milbemycin oxime is an orally active macrolide with broad-spectrum antiparasitic activity. Milbemycin oxime is a mixture of oximes consisting of oxime derivatives corresponding to milbemycin A4 and A3. Milbemycin oxime binds to glutamate-gated chloride channels and has inhibitory potency against intestinal nematodes and lung/heart worms .
|
-
- HY-128423
-
Acetylisovaleryltylosin tartrate
|
Antibiotic
Bacterial
NF-κB
Apoptosis
|
Infection
Inflammation/Immunology
|
Tylvalosin (Acetylisovaleryltylosin) tartrate is an orally active, broad-spectrum macrolide antibiotic with antimicrobial activity. Tylvalosin tartrate is an antiviral agent useful in studying PRRSV infection. Tylvalosin tartrate induces apoptosis. Tylvalosin tartrate also has anti-inflammatory activity, relieves oxidative stress, and alleviates acute lung injury by inhibiting NF-κB activation .
|
-
- HY-13678
-
SM 7338
|
Penicillin-binding protein (PBP)
Bacterial
Antibiotic
|
Infection
Cancer
|
Meropenem (SM 7338) is a carbapenem antibiotic with broad-spectrum antibacterial activity. Meropenem has activity against susceptible and resistant N. gonorrhoeae (MIC value of 0.02-0.06 mg/mL), H. influenzae (MIC value of 0.03-0.12 mg/mL), and H. ducreyi (MIC value of 0.015-0.12 mg/mL) .
|
-
- HY-17028
-
|
Bacterial
Antibiotic
DNA/RNA Synthesis
Topoisomerase
|
Infection
Inflammation/Immunology
|
Besifloxacin Hydrochloride is a fourth generation fluoroquinolone antibiotic. Besifloxacin Hydrochloride is a DNA gyrase and topoisomerase IV inhibitor. Besifloxacin Hydrochloride has broad-spectrum antibacterial activity, it is effective against Gram-negative and Gram-positive aerobic and anaerobic strains and reduces the incidence of drug resistance. Besifloxacin Hydrochloride has anti-inflammatory activity. Besifloxacin Hydrochloride can be used in bacterial conjunctivitis research .
|
-
- HY-P10228
-
|
Fungal
Bacterial
|
Infection
|
S-Thanatin is an insect antimicrobial peptide with potent broad-spectrum antibacterial activity. S-Thanatin can inhibit the activity of Gram-negative bacteria, Gram-positive bacteria, and fungi, without cytotoxicity. The antibacterial activity of S-Thanatin is not affected by PH value, but monovalent cations (Na +/K +) can reduce its antibacterial activity against Gram-negative bacteria in a dose-dependent manner .
|
-
- HY-W019852
-
|
Fungal
|
Infection
|
Flutriafol is a triazole fungicide with broad spectrum fungicidal activity.
|
-
- HY-W016420
-
MK-0955 sodium
|
Bacterial
Antibiotic
|
Infection
Cancer
|
Fosfomycin (MK-0955) sodium is a blood-brain barrier penetrating, broad-spectrum antibiotic by irreversibly inhibiting an early stage in cell wall synthesis. Fosfomycin sodium shows both in vivo and in vitro activity against a wide range of bacteria, including multidrug-resistant (MDR), extensively drug-resistant (XDR), and pan-drug-resistant (PDR) bacteria .
|
-
- HY-10969
-
GX15-070 Mesylate
|
Bcl-2 Family
Autophagy
Parasite
|
Infection
Cancer
|
Obatoclax Mesylate (GX15-070 Mesylate), a BH3 mimetic, is a pan-BCL-2 family proteins inhibitor with a Ki of 220 nM for BCL-2 . Obatoclax Mesylate induces autophagy-dependent cell death and targets cyclin D1 for proteasomal degradation. Obatoclax Mesylate has anti-cancer and broad-spectrum antiparasitic activity .
|
-
- HY-106574
-
BAL5788
|
Bacterial
|
Infection
Inflammation/Immunology
|
Ceftobiprole medocaril (BAL5788) is the parenteral proagent of Ceftobiprole (HY-112579). Ceftobiprole is a parenteral pyrrolidinone cephalosporin. Ceftobiprole is a broad-spectrum cephalosporin with high levels of in vitro activity against methicillin- (MRSA) and vancomycin-resistant staphylococci (VRSA) and penicillin-resistant streptococci. Ceftobiprole also inhibits gram-positive and gram-negative pathogens .
|
-
- HY-169224
-
|
SARS-CoV
|
Infection
|
SARS-CoV-2-IN-100 (Compound 172) is an inhibitor of SARS-CoV-2, demonstrating broad-spectrum antiviral activity against various SARS-CoV-2 variants. SARS-CoV-2-IN-100 exhibits synergistic effects with Nirmatrelvir, which can reduce the risk of antiviral drug resistance .
|
-
- HY-P5724
-
|
Bacterial
|
Infection
|
Nv-CATH is an antibacterial peptide of frog origin. Nv-CATH has broad-spectrum antibacterial activity against gram-positive and gram-negative bacteria. Nv-CATH significantly protects mice from fatal infections caused by Staphylococcus aureus. Nv-CATH protects mice from bacterial infection through antimicrobial immunoregulatory duality .
|
-
- HY-W042191R
-
|
Reference Standards
Fungal
Apoptosis
Caspase
Bcl-2 Family
MDM-2/p53
PARP
|
Infection
Cancer
|
Oxychlororaphine (Standard) is the analytical standard of Oxychlororaphine. This product is intended for research and analytical applications. Oxychloroaphine could be isolated from the bacterium Pantoea agglomerans naturally present in soil. Oxychloroaphine has broad-spectrum antifungal activity. Oxychloroaphine has cytotoxicity in a dose-dependent manner and induces apoptosis. Oxychloroaphine can be used in research of cancer[1][2].
|
-
- HY-B1923A
-
Pipracil hydrate
|
Antibiotic
Bacterial
Beta-lactamase
Penicillin-binding protein (PBP)
|
Infection
Cancer
|
Piperacillin hydrate is a semisynthetic broad-spectrum β-lactam antibiotic which exhibits potent bactericidal activity against Gram-negative bacteria as well as select Gram-positive strains through penicillin-binding proteins. Piperacillin hydrate is most commonly used in combination with the β-lactamase inhibitor Tazobactam (HY-B1418) .
|
-
- HY-W018025R
-
-
- HY-106574A
-
BAL5788 sodium
|
Bacterial
|
Infection
Inflammation/Immunology
|
Ceftobiprole medocaril (BAL5788) sodium is the parenteral proagent of Ceftobiprole (HY-112579). Ceftobiprole is a parenteral pyrrolidinone cephalosporin. Ceftobiprole is a broad-spectrum cephalosporin with high levels of in vitro activity against methicillin- (MRSA) and vancomycin-resistant staphylococci (VRSA) and penicillin-resistant streptococci. Ceftobiprole also inhibits gram-positive and gram-negative pathogens .
|
-
- HY-B1075A
-
MK-0955
|
Bacterial
Antibiotic
|
Infection
Cancer
|
Fosfomycin (MK-0955) is a broad-spectrum antibiotic. Fosfomycin can cross blood-brain barrier penetrating, and irreversibly inhibits an early stage in cell wall synthesis. Fosfomycin shows anti-bacteria activity for a range of bacteria, including multidrug-resistant (MDR), extensively drug-resistant (XDR), and pan-drug-resistant (PDR) bacteria .
|
-
- HY-168034
-
|
STING
|
Infection
Inflammation/Immunology
|
diABZI-4 is an oral active STING agonist with broad-spectrum antiviral activity. diABZI-4 induces the production of pro-inflammatory cytokines and lymphocyte activation by activating STING, thereby inhibiting the replication of influenza A virus (IAV), SARS-CoV-2, and human rhinovirus (HRV), with an EC50 range of 11.8-199 nM .
|
-
- HY-76200S
-
UK-109496-d3
|
Fungal
|
Infection
|
Voriconazole-d3 is the deuterium labeled Voriconazole. Voriconazole (UK-109496) is a second-generation, broad-spectrum triazole antifungal agent that inhibits fungal ergosterol biosynthesis. Voriconazole exerts its antifungal activity by inhibition of 14-α-lanosterol demethylation, which is mediated by fungal cytochrome P450 enzymes .
|
-
- HY-10969A
-
GX15-070
|
Bcl-2 Family
Autophagy
Parasite
|
Infection
Cancer
|
Obatoclax (GX15-070), a BH3 mimetic, is a pan-BCL-2 family proteins inhibitor with a Ki of 220 nM for BCL-2 . Obatoclax induces autophagy-dependent cell death and targets cyclin D1 for proteasomal degradation. Obatoclax has anti-cancer and broad-spectrum antiparasitic activity .
|
-
- HY-N8461
-
3-Hydroxypropionaldehyde; 3-Hydroxypropanal
|
Bacterial
|
Infection
|
Reuterin is a broad-spectrum antimicrobial agent active against Gram positive and Gram negative bacteria, as well as yeasts, moulds and protozoa. Reuterin is produced by specific strains of Lactobacillus reuteri during anaerobic metabolism of glycerol. Reuterin also demonstrates potent antimicrobial activity against a broad panel of human and poultry meat campylobacter spp. Isolates .
|
-
- HY-13678A
-
SM 7338 trihydrate
|
Penicillin-binding protein (PBP)
Bacterial
Antibiotic
|
Infection
Cancer
|
Meropenem trihydrate (SM 7338 trihydrate) is a carbapenem antibiotic with broad-spectrum antibacterial activity. Meropenem trihydrate has activity against susceptible and resistant N. gonorrhoeae (MIC value of 0.02-0.06 mg/mL), H. influenzae (MIC value of 0.03-0.12 mg/mL), and H. ducreyi (MIC value of 0.015-0.12 mg/mL) .
|
-
- HY-120638
-
|
Topoisomerase
|
Cancer
|
BMS-250749 is a topoisomerase I (Top I) inhibitor of the fluoroglycosyl-3,9-difluoroindolecarbazole class. BMS-250749 exhibits potent cytotoxicity and selectivity, and shows curative antitumor activity against Lewis lung cancer. BMS-250749 exhibits broad-spectrum antitumor activity superior to CPT-11 in certain preclinical xenograft models. .
|
-
- HY-12098
-
MPC-6827 hydrochloride
|
Microtubule/Tubulin
|
Cancer
|
Verubulin hydrochloride (MPC-6827 hydrochloride) is a blood brain barrier permeable microtubule-disrupting agent, with potent and broad-spectrum in vitro and in vivo cytotoxic activities. Verubulin hydrochloride (MPC-6827 hydrochloride) exhibits potent anticancer activity in human MX-1 breast and other mouse xenograft cancer models. Verubulin hydrochloride (MPC 6827 hydrochloride) is a promising candidate for the treatment of multiple cancer types .
|
-
- HY-B0330D
-
Dextrofloxacin
|
Bacterial
Antibiotic
|
Infection
|
(R)-Ofloxacin is the dextrorotatory enantiomer of Ofloxacin (HY-B0125) and is an orally effective fluoroquinolone antibiotic. (R)-Ofloxacin can inhibit the activity of bacterial DNA topoisomerase II, interfere with bacterial DNA replication and repair, and exert a bactericidal effect. (R)-Ofloxacin has a broad-spectrum antibacterial activity and has inhibitory effects on both Gram-negative and Gram-positive bacteria .
|
-
- HY-14904
-
|
SARS-CoV
Influenza Virus
CHIKV
|
Infection
|
Umifenovir is a potent, orally active broad-spectrum antiviral agent with activity against a number of enveloped and non-enveloped viruses. Umifenovir is used as an anti-influenza virus agent. Umifenovir could effectively inhibit the fusion of virus with host cells . Umifenovir is an efficient inhibitor of SARS-CoV-2 in vitro . Umifenovir shows anti-inflammatory activity .
|
-
- HY-18234AR
-
|
Reference Standards
Cathepsin
Ser/Thr Protease
Virus Protease
|
Infection
Inflammation/Immunology
|
Leupeptin (hemisulfate) (Standard) is the analytical standard of Leupeptin (hemisulfate). This product is intended for research and analytical applications. Leupeptin hemisulfate is a broad-spectrum, membrane-permeable protease inhibitor. Leupeptin hemisulfate potently inhibits serine, cysteine and threonine proteases. Leupeptin hemisulfate inhibits Mpro (the main protease of SARS-CoV-2) and also has anti-inflammatory activity[1][2][3].
|
-
- HY-N14984
-
|
Fungal
|
Infection
|
Galbonolides A exhibits biological activity against a broad spectrum of fungi .
|
-
- HY-B0210
-
-
- HY-16745A
-
KRP-AM1977 hydrochloride
|
Bacterial
|
Infection
|
Lascufloxacin (KRP-AM1977) hydrochloride is a potent antibacterial compound candidate with broad-spectrum activity against various clinical isolates. Lascufloxacin hydrochloride shows the most potent activity against Gram-positive bacteria compared to other tested quinolones. Lascufloxacin hydrochloride demonstrates incomplete cross-resistance against existing quinolone-resistant strains. Lascufloxacin hydrochloride has potent inhibitory activity against both wild-type and mutated target enzymes.
|
-
- HY-172170
-
|
Histone Demethylase
|
Cancer
|
LSD1-IN-39 (Compound 14) is a reversible inhibitor for LSD1 with an IC50 of 0.18 μM. LSD1-IN-39 exhibits broad-spectrum anti-proliferative activity against cancer cells, inhibits the cell migration of HepG2 and inhibits the epithelial-mesenchymal transition. LSD1-IN-39 exhibits antitumor activity in mouse models .
|
-
- HY-114220
-
|
Fungal
|
Infection
|
T-2307, an arylamidine, has antifungal activities in vitro and in vivo. T-2307 exhibits broad-spectrum activity against clinically significant pathogens, including Candida species (MIC range, 0.00025 to 0.0078 μg/ml), Cryptococcus neoformans (MIC range, 0.0039 to 0.0625 μg/ml), and Aspergillus species (MIC range, 0.0156 to 4 μg/mL) .
|
-
- HY-17028A
-
|
Bacterial
Antibiotic
DNA/RNA Synthesis
Topoisomerase
|
Infection
Inflammation/Immunology
|
(Rac)-Besifloxacin Hydrochloride is a fourth generation fluoroquinolone antibiotic. (Rac)-Besifloxacin Hydrochloride is a DNA gyrase and topoisomerase IV inhibitor. (Rac)-Besifloxacin Hydrochloride has broad-spectrum antibacterial activity, it is effective against Gram-negative and Gram-positive aerobic and anaerobic strains and reduces the incidence of drug resistance. (Rac)-Besifloxacin Hydrochloride has anti-inflammatory activity. Besifloxacin Hydrochloride can be used in bacterial conjunctivitis research .
|
-
- HY-14904AS
-
|
Isotope-Labeled Compounds
Influenza Virus
SARS-CoV
CHIKV
|
Infection
|
Umifenovir-d6 (hydrochloride) is the deuterium labeled Umifenovir hydrochloride. Umifenovir hydrochloride is a potent, orally active broad-spectrum antiviral with activity against a number of enveloped and non-enveloped viruses. Umifenovir hydrochloride is used as an anti-influenza virus agent. Umifenovir hydrochloride could effectively inhibit the fusion of virus with host cells . Umifenovir hydrochloride is an efficient inhibitor of SARS-CoV-2 in vitro. Anti-inflammatory activity .
|
-
- HY-159969
-
|
Bacterial
Antibiotic
|
Infection
|
MLEB-22043 is a synthetic siderophore-monobactam conjugate that is taken up into bacteria via its synthetic siderophore component by TonB-dependent transporters. Once inside the bacteria, it exerts antibacterial activity through its β-lactam component. MLEB-22043 is a broad-spectrum antibiotic with significant inhibitory activity against Klebsiella pneumoniae, Escherichia coli, Acinetobacter baumannii, and Pseudomonas aeruginosa .
|
-
- HY-B1075
-
MK-0955 calcium
|
Bacterial
Antibiotic
|
Infection
Cancer
|
Fosfomycin (MK-0955) calcium is a blood-brain barrier penetrating, broad-spectrum antibiotic by irreversibly inhibiting an early stage in cell wall synthesis. Fosfomycin calcium shows both in vivo and in vitro activity against a wide range of bacteria, including multidrug-resistant (MDR), extensively drug-resistant (XDR), and pan-drug-resistant (PDR) bacteria .
|
-
- HY-W770956
-
SCE-963-15N2; Cefotiam Dihydrochloride-15N2
|
Isotope-Labeled Compounds
Bacterial
Antibiotic
|
Infection
|
Cefotiam- 13C, 15N2 (SCE-963- 13C, 15N2) is the 13C- and 15N-labeled Cefotiam (HY-B0734). Cefotiam (SCE-963) is a parenteral cephalosporin antibiotic. Cefotiam has broad-spectrum activity against Gram-positive and Gram-negative bacteria .
|
-
- HY-15491
-
|
COX
Apoptosis
|
Cancer
|
AG-024322 is a potent ATP-competitive pan-CDK inhibitor against cell cycle kinases CDK1, CDK2, and CDK4 with Ki values in the 1-3 nM range . AG-024322 displays broad-spectrum anti-tumor activity and clear target modulation in vivo. AG-024322 induces cell apoptosis .
|
-
- HY-B1464R
-
|
Reference Standards
Bacterial
HBV
|
Infection
Inflammation/Immunology
|
Cetylpyridinium (chloride) (Standard) is the analytical standard of Cetylpyridinium (chloride). This product is intended for research and analytical applications. Cetylpyridinium chloride, a cationic quaternary ammonium compound, is an anti-bacterial agent with broad-spectrum activity. Cetylpyridinium chloride is an effective anti-HBV capsid assembly inhibitor with an IC50 of 2.5 μM. Cetylpyridinium chloride is used in pesticides and various types of mouthwashes, and other personal care products .
|
-
- HY-B0609
-
MK-0955 tromethamine
|
Bacterial
Antibiotic
|
Infection
Cancer
|
Fosfomycin (MK-0955) tromethamine is a blood-brain barrier penetrating, broad-spectrum antibiotic by irreversibly inhibiting an early stage in cell wall synthesis. Fosfomycin tromethamine shows both in vivo and in vitro activity against a wide range of bacteria, including multidrug-resistant (MDR), extensively drug-resistant (XDR), and pan-drug-resistant (PDR) bacteria .
|
-
- HY-B1257
-
Sodium cefmetazole
|
Bacterial
Antibiotic
|
Infection
Cancer
|
Cefmetazole sodium (Sodium cefmetazole) is a semisynthetic cephamycin antibiotic with broad-spectrum antibacterial activity, covering gram-positive, gram-negative, and anaerobic bacteria. Cefmetazole sodium binds to penicillin binding proteins (PBPs), resulting in interfering bacterial cell wall biosynthesis. Cefmetazole sodium is used for the research of gynecologic, intraabdominal, urinary tract, respiratory tract and skin and soft tissue infections .
|
-
- HY-B1595
-
CS 1170
|
Antibiotic
Bacterial
|
Infection
Cancer
|
Cefmetazole (CS 1170) is a semisynthetic cephamycin antibiotic with broad-spectrum antibacterial activity, covering gram-positive, gram-negative and anaerobic bacteria. Cefmetazole binds to penicillin binding proteins (PBPs), resulting in interfering bacterial cell wall biosynthesis. Cefmetazole is used for the research of gynecologic, intraabdominal, urinary tract, respiratory tract and skin and soft tissue infections .
|
-
- HY-76200R
-
UK-109496 (Standard)
|
Reference Standards
Fungal
Bacterial
|
Infection
Cancer
|
Voriconazole (Standard) is the analytical standard of Voriconazole. This product is intended for research and analytical applications. Voriconazole (UK-109496) is a second-generation, broad-spectrum triazole antifungal agent that inhibits fungal ergosterol biosynthesis. Voriconazole exerts its antifungal activity by inhibition of 14-α-lanosterol demethylation, which is mediated by fungal cytochrome P450 enzymes .
|
-
- HY-147349
-
ANT3310 sodium
|
Beta-lactamase
Bacterial
|
Infection
|
Pilabactam (ANT3310) sodium is a broad-spectrum covalent Serine β-Lactamase inhibitor, with IC50 values ranging from 1 nM to 175 nM (a panel of Serine β-Lactamase). Pilabactam sodium potentiates activity of β-lactam antibiotics against Carbapenem-Resistant Enterobacterales (CRE) and Acinetobacter baumannii (CRAB). Pilabactam sodium can be used in the research of bacterial infection .
|
-
- HY-126113
-
|
Flavivirus
Dengue Virus
Influenza Virus
HCV
|
Infection
|
KIN101 is a potent RNA viral inhibitor with IC50s of 2 μM, >5 μM for influenza virus and Dengue virus (DNV), respectively. KIN101, an isoflavone agonist of IRF-3 dependent signaling, induces IRF-3 nuclear translocation. KIN101 has broad-spectrum activity against RNA viruses .
|
-
- HY-146196
-
|
Bacterial
|
Infection
|
Anticandidal agent-1 (compound c2) is a potent and broad-spectrum anticandidal agent. Anticandidal agent-1 shows anticandidal activity against C. albicans and C. glabrata, with MIC50 values of 8.65 and 13.51 μg/mL, respectively. Anticandidal agent-1 inhibits biofilm by blocking hyphal elongation and filamentation .
|
-
- HY-14956S
-
TG-873870-d3
|
Bacterial
|
Inflammation/Immunology
|
Nemonoxacin-d3 is the deuterium labeled Nemonoxacin. Nemonoxacin (TG-873870) is an orally active and potent broad-spectrum antibiotic. Nemonoxacin shows good inhibitory activity against different species of staphylococci, streptococci, and enterococci, Neisseria gonorrhoeae, and Haemophilus influenza. Nemonoxacin can be used in the study of bacterial infections and community-acquired pneumonia .
|
-
- HY-B0226A
-
(E)-Nitrofural
|
Bacterial
Parasite
|
Infection
|
(E)-Nitrofurazone ((E)-Nitrofural) is a topical broad-spectrum antibacterial agent effective against both Gram-negative and Gram-positive bacteria. (E)-Nitrofurazone also possesses antiprotozoal and antiparasitic activities. (E)-Nitrofurazone is commonly used in the research of superficial wounds, burns, skin infections, pyoderma, infectious skin diseases, trypanosomiasis, and acute bacillary dysentery .
|
-
- HY-136063R
-
|
Reference Standards
Fungal
Cytochrome P450
|
Infection
|
Mefentrifluconazole (Standard) is the analytical standard of Mefentrifluconazole. This product is intended for research and analytical applications. Mefentrifluconazole is a novel azole derivative and used as an agrochemical broad-spectrum antifungal agent. Mefentrifluconazole is a potent, selective and orally active fungal CYP51 (Kd= 0.5 nM) inhibitor, but shows less inhibitory activity on human aromatase (IC50=0.92 μM)[1].
|
-
- HY-14956S1
-
TG-873870-d3-1
|
Bacterial
|
Inflammation/Immunology
|
Nemonoxacin-d3-1 is the deuterium labeled Nemonoxacin. Nemonoxacin (TG-873870) is an orally active and potent broad-spectrum antibiotic. Nemonoxacin shows good inhibitory activity against different species of staphylococci, streptococci, and enterococci, Neisseria gonorrhoeae, and Haemophilus influenza. Nemonoxacin can be used in the study of bacterial infections and community-acquired pneumonia .
|
-
- HY-14956S2
-
TG-873870-d4
|
Bacterial
|
Inflammation/Immunology
|
Nemonoxacin-d4 is the deuterium labeled Nemonoxacin. Nemonoxacin (TG-873870) is an orally active and potent broad-spectrum antibiotic. Nemonoxacin shows good inhibitory activity against different species of staphylococci, streptococci, and enterococci, Neisseria gonorrhoeae, and Haemophilus influenza. Nemonoxacin can be used in the study of bacterial infections and community-acquired pneumonia .
|
-
- HY-147349A
-
ANT3310
|
Bacterial
Beta-lactamase
|
Infection
|
Pilabactam (ANT3310) is a broad-spectrum covalent Serine β-Lactamase inhibitor, with IC50 values ranging from 1 nM to 175 nM (a panel of Serine β-Lactamase). Pilabactam potentiates activity of β-lactam antibiotics against Carbapenem-Resistant Enterobacterales (CRE) and Acinetobacter baumannii (CRAB). Pilabactam can be used in the research of bacterial infection .
|
-
- HY-124894
-
|
Fungal
|
Infection
|
(+)-Benalaxyl is a broad-spectrum benzamide fungicide. (+)-Benalaxyl inhibits the growth of the freshwater algae S. obliquus, with an EC50 value of 8.441 mg/L. (+)-Benalaxyl can induce the production of chlorophyll a and b, as well as increase the activity of superoxide dismutase (SOD) and the generation of malondialdehyde (MDA). (+)-Benalaxyl has inhibitory effects on catalase (CAT). (+)-Benalaxyl is effective against diseases caused by oomycetes .
|
-
- HY-B0210C
-
-
- HY-B1080
-
|
HIF/HIF Prolyl-Hydroxylase
Influenza Virus
|
Infection
Neurological Disease
|
Tilorone dihydrochloride is an orally active interferon (IFN) inducer with broad-spectrum antiviral activities. Tilorone dihydrochloride possesses robust anti-Severe fever with thrombocytopenia syndrome virus (SFTSV) activity in vitro and in vivo through stimulation of host innate immunity. Tilorone dihydrochloride can penetrate the blood-brain barrier to activate HIF in the CNS .Tilorone dihydrochloride exhibits an inhibitory activity with EC50 of 230 nM against Ebola virus (EBOV) .
|
-
- HY-17028R
-
|
Reference Standards
Bacterial
Antibiotic
DNA/RNA Synthesis
Topoisomerase
|
Infection
|
Besifloxacin (Hydrochloride) (Standard) is a fourth generation fluoroquinolone antibiotic. Besifloxacin Hydrochloride (Standard) is a DNA gyrase and topoisomerase IV inhibitor. Besifloxacin Hydrochloride (Standard) has broad-spectrum antibacterial activity, it is effective against Gram-negative and Gram-positive aerobic and anaerobic strains and reduces the incidence of drug resistance. Besifloxacin Hydrochloride (Standard) has anti-inflammatory activity. Besifloxacin Hydrochloride (Standard) can be used in bacterial conjunctivitis research .
|
-
- HY-13678S
-
SM 7338-d6
|
Bacterial
Antibiotic
|
Infection
|
Meropenem-d6 is the deuterium labeled Meropenem. Meropenem (SM 7338) is a carbapenem antibiotic with broad-spectrum antibacterial activity. Meropenem has activity against susceptible and resistant N. gonorrhoeae (MIC value of 0.02-0.06 mg/mL), H. influenzae (MIC value of 0.03-0.12 mg/mL), and H. ducreyi (MIC value of 0.015-0.12 mg/mL) .
|
-
- HY-123319A
-
|
Bacterial
Antibiotic
|
Infection
|
Antofloxacin is a well tolerate, orally active and broad-spectrum 8-amino-fluoroquinolone with potent antibacterial activities. Antofloxacin shows superior antibacterial activity against gyrA mutation-positive H. pylori strains, especially in Asn87- mutated strains, compared to levofloxacin. Antofloxacin is a weak, reversible inhibitor of CYP1A2 for the research of infections caused by a diverse group of bacterial species .
|
-
- HY-123319
-
|
Bacterial
Antibiotic
|
Infection
|
Antofloxacin hydrochloride is a well tolerate, orally active and broad-spectrum 8-amino-fluoroquinolone with potent antibacterial activities. Antofloxacin hydrochloride shows superior antibacterial activity against gyrA mutation-positive H. pylori strains, especially in Asn87- mutated strains, compared to levofloxacin. Antofloxacin hydrochloride is a weak, reversible inhibitor of CYP1A2 for the research of infections caused by a diverse group of bacterial species .
|
-
- HY-N15091
-
|
Fungal
|
Infection
|
Formamicin has broad spectrum and strong anti-plant pathogenic fungi activity .
|
-
- HY-N14308
-
|
Antibiotic
Bacterial
|
Infection
|
Aspiculamycin, a cytosine nucleoside, is an antibiotic. Aspiculamycin has a broad spectrum of antibacterial activity .
|
-
- HY-111023
-
TG-873870 malate
|
Antibiotic
Bacterial
|
Infection
|
Nemonoxacin (TG-873870) malate is a nonfluorinated quinolone antibiotic. Nemonoxacin malate has broad-spectrum activity against Gram-positive, Gram-negative and atypical pathogens. Nemonoxacin malate can inhibit drug-resistant Streptococcus pneumoniae and (HY-121544) Methicillin-resistant Staphylococcus aureus. Nemonoxacin malate can be used for the research of community-acquired pneumonia .
|
-
- HY-B0736
-
-
- HY-110234
-
McN 4853 D12 ; RWJ 17021 D12
|
iGluR
GABA Receptor
Sodium Channel
Calcium Channel
Potassium Channel
Carbonic Anhydrase
|
Neurological Disease
|
Topiramate D12 (McN 4853 D12) is a deuterium labeled Topiramate. Topiramate is a broad-spectrum antiepileptic agent. Topiramate is a GluR5 receptor antagonist. Topiramate produces its antiepileptic effects through enhancement of GABAergic activity, inhibition of kainate/AMPA receptors, inhibition of voltage-sensitive sodium and calcium channels, increases in potassium conductance, and inhibition of carbonic anhydrase .
|
-
- HY-B0736A
-
FI7056
|
Fungal
Autophagy
Apoptosis
p38 MAPK
Microtubule/Tubulin
|
Infection
Cancer
|
Sertaconazole nitrate (FI7056) is a broad-spectrum topical antifungal agent, exhibits anti-inflammatory activity via activation of a p38-COX-2-PGE2 pathway. Sertaconazole nitrate is also a microtubule inhibitor, shows antiproliferative effect, induces apoptosis and autophagy, and can also inhibit the migration of cells .
|
-
- HY-107801
-
Imunovir; Delimmun; Groprinosin
|
Interleukin Related
HSV
HIV
HPV
|
Infection
Inflammation/Immunology
|
Inosine pranobex is an orally active immunomodulator. Inosine pranobex has broad-spectrum antiviral activity. Inosine pranobex inhibits human immunodeficiency virus (HIV), herpes simplex virus (HSV), vaccinia virus (VACV), human tumor virus (HPV), Cytomegalovirus, influenza virus (INFV), parainfluenza virus (PIV), and Epstein-Barr virus
.
|
-
- HY-128932
-
MT-141
|
Antibiotic
Bacterial
PPAR
Prostaglandin Receptor
PTEN
Akt
mTOR
|
Infection
Cardiovascular Disease
Endocrinology
|
Cefminox sodium (MT-141) is a semisynthetic cephamycin, which exhibits antibacterial activity. Cefminox sodium is a broad-spectrum, bactericidal cephalosporin antibiotic. Cefminox sodium also acts as a dual agonist of prostacyclin receptor (IP) and PPARγ. Cefminox sodium upregulates cAMP production and PTEN expression and inhibits Akt/mTOR signaling. Cefminox sodium also prevents pulmonary arterial hypertension in rat model .
|
-
- HY-N7224
-
SF-1854
|
Bacterial
Antibiotic
|
Infection
|
N-Formylfortimicin A (SF-1854) is an aminoglycoside antibiotic with broad-spectrum antibacterial activity. It primarily acts on bacterial ribosomes to inhibit protein synthesis and exhibits notable inhibitory effects against various Gram-positive and Gram-negative bacteria (e.g., E. coli with a MIC of 12.5-50 μg/mL), making it a potential candidate for research on bacterial infection-related diseases .
|
-
- HY-168999
-
|
Tomato Spotted Wilt Virus (TSWV)
|
Infection
|
TSWV-IN-2 (Compound Z9) is an inhibitor of TSWV N protein, with an EC50 of 65.3 μg/mL against TSWV. TSWV-IN-2 has broad-spectrum antiviral activity against plant viruses. TSWV-IN-2 targets the TSWV N protein, interferes with the formation of condensates between the N protein and RNA, and inhibits the replication of viral ribonucleoproteins .
|
-
- HY-167707
-
|
Apoptosis
|
Cancer
|
Q-VD(OMe)-OPh is a broad-spectrum caspase inhibitor with high activity in inhibiting apoptosis. Q-VD(OMe)-OPh is not toxic to cells at high concentrations, demonstrating its safety. Q-VD(OMe)-OPh exhibits comparable effectiveness to other widely used inhibitors in preventing apoptosis mediated by caspase 9/3, caspase 8/10, and caspase 12 .
|
-
- HY-149360
-
|
P-glycoprotein
|
Cancer
|
P-gb-IN-1 (compound Ⅲ-8), a 2,5-disubstituted furan derivative, is a highly effective, broadspectrum P-glycoprotein (P-gp) inhibitor. P-gb-IN-1 displayed the reversal activity by inhibiting P-gp efflux. P-gb-IN-1 has a potent affinity to P-gp by forming H-bond interactions with residues Asn 721 and Met 986. P-gb-IN-1 possesses broad-spectrum reversal activity and low toxicity in MCF-7/ADR cells .
|
-
- HY-N0275
-
(±)-10-HCPT
|
Topoisomerase
|
Cancer
|
(±)-10-Hydroxycamptothecin is an indole alkaloid that inhibits the activity of topoisomerase I and has a broad spectrum of anticancer activity.
|
-
- HY-N14187
-
|
Antibiotic
Bacterial
|
Infection
|
Aspergillic acid is an antibiotic found in Aspergillus flavus. Aspergillic acid has a broad spectrum of antibacterial activity .
|
-
- HY-B0210A
-
CP 52640-2
|
Bacterial
Antibiotic
|
Infection
|
Cefoperazone sodium salt (CP 52640-2), a semisynthetic cephalosporin, has a broad spectrum of antibacterial activity .
|
-
- HY-100379
-
-
- HY-14904AR
-
|
Reference Standards
Influenza Virus
SARS-CoV
CHIKV
|
Infection
|
Umifenovir (hydrochloride) (Standard) is the analytical standard of Umifenovir (hydrochloride). This product is intended for research and analytical applications. Umifenovir hydrochloride is a potent, orally active broad-spectrum antiviral with activity against a number of enveloped and non-enveloped viruses. Umifenovir hydrochloride is used as an anti-influenza virus agent. Umifenovir hydrochloride could effectively inhibit the fusion of virus with host cells . Umifenovir hydrochloride is an efficient inhibitor of SARS-CoV-2 in vitro. Anti-inflammatory activity .
|
-
- HY-B1050
-
SB-265805S; LB-20304a
|
Bacterial
Antibiotic
DNA/RNA Synthesis
Topoisomerase
|
Infection
|
Gemifloxacin mesylate (SB-265805S; LB-20304a) is an orally active broad-spectrum quinolone antibacterial antibiotic. Gemifloxacin mesylate inhibits DNA synthesis by inhibiting DNA gyrase and Topoisomerase IV activities. Gemifloxacin mesylate has potent antibacterial activities against gram-positive bacteria in vitro efficacy study, particularly Streptococci and Staphylococci. Gemifloxacin mesylate has been used in the research of respiratory tract infections .
|
-
- HY-151422
-
|
Fungal
|
Infection
Cancer
|
Chitin synthase inhibitor 12 is a chitin synthase inhibitor. Chitin synthase inhibitor 12 shows excellent inhibitory activity with an IC50 value of 0.16 mM. Chitin synthase inhibitor 12 also is a broad-spectrum antifungal agent and has significantly antifungal activity against drug-resistant fungal variants, such as C. albicans and C. neoformans. Chitin synthase inhibitor 12 can be used for the research of invasive fungal infections (IFIs) .
|
-
- HY-14737A
-
TAK-599 hydrate; PPI0903 hydrate
|
Antibiotic
Bacterial
|
Infection
|
Ceftaroline fosamil hydrate is a potent cephalosporin antibiotic. Ceftaroline fosamil hydrateshows broad-spectrum activity against Gram-positive pathogens, including methicillin-resistant Staphylococcus aureus (MRSA) and multidrug-resistant Streptococcus pneumoniae, and common Gram-negative organisms. Ceftaroline fosamil hydrate has anti-infective activity, and can be used for the research of complicated skin and skin structure infections (cSSSIs) and community-acquired bacterial pneumonia (CABP) .
|
-
- HY-10581A
-
AM-1155 hydrochloride; BMS-206584 hydrochloride; PD135432 hydrochloride
|
Bacterial
Topoisomerase
Antibiotic
|
Infection
|
Gatifloxacin hydrochloride (AM-1155; BMS-206584; PD135432) is a potent fluoroquinolone antibiotic with broad-spectrum antibacterial activity. Gatifloxacin hydrochloride inhibits bacterial type II topoisomerases (IC50=13.8 μg/ml for S. aureus topoisomerase IV) and E. coli DNA gyrase (IC50 = 0.109 μg/ml) . Gatifloxacin hydrochloride can be used to treat bacterial conjunctivitis in vivo.
|
-
- HY-155570
-
|
PI3K
Apoptosis
Caspase
PARP
|
Cancer
|
Anticancer agent 137 (8q) is a potent PI3k inhibitor. Anticancer agent 137 has broad-spectrum anticancer activity. Anticancer agent 137 induces G2/M cell cycle arrest and apoptosis. Anticancer agent 137 increases cleaved PARP, caspase 3, and 7. Anticancer agent 137 can be used in research of cancer .
|
-
- HY-W250302R
-
|
Biochemical Assay Reagents
Reference Standards
|
Others
|
Methylbenzethonium (chloride) (Standard) is the analytical standard of Methylbenzethonium (chloride). This product is intended for research and analytical applications. Methylbenzethonium chloride is a quaternary ammonium compound commonly used as a preservative and disinfectant in a variety of personal care and healthcare products. Methylbenzethonium chloride has several properties that make it suitable for these applications, including its broad-spectrum antibacterial activity against bacteria, viruses and fungi. In addition, it is used as a preservative in cosmetic and pharmaceutical formulations to prevent the growth of microorganisms.
|
-
- HY-B1064R
-
Clindamycin 2-phosphate (Standard); U-28508 (Standard)
|
Reference Standards
Bacterial
Antibiotic
Parasite
|
Infection
|
Clindamycin phosphate (Standard) is the analytical standard of Clindamycin phosphate. This product is intended for research and analytical applications. Clindamycin phosphate (Clindamycin 2-phosphate) is a broad-spectrum bacteriostatic lincosamide antibiotic. Clindamycin phosphate is the proagent of Clindamycin (HY-B1455) with no antimicrobial activity in vitro but can be rapidly converted in vivo to the active parent agent, Clindamycin, by phosphatase ester hydrolysis. Clindamycin phosphate can be used for researching acne and bacterial vaginosis .
|
-
- HY-10581B
-
AM-1155 mesylate; BMS-206584 mesylate; PD135432 mesylate
|
Bacterial
Topoisomerase
Antibiotic
|
Infection
|
Gatifloxacin mesylate (AM-1155; BMS-206584; PD135432) is a potent fluoroquinolone antibiotic with broad-spectrum antibacterial activity. Gatifloxacin mesylate inhibits bacterial type II topoisomerases (IC50=13.8 μg/ml for S. aureus topoisomerase IV) and E. coli DNA gyrase (IC50 = 0.109 μg/ml) . Gatifloxacin mesylate can be used to treat bacterial conjunctivitis in vivo.
|
-
- HY-B1923R
-
Pipracil (Standard)
|
Bacterial
Reference Standards
Antibiotic
Beta-lactamase
Penicillin-binding protein (PBP)
|
Infection
Cancer
|
Piperacillin (Standard) is the analytical standard of Piperacillin. This product is intended for research and analytical applications. Piperacillin is a semisynthetic broad-spectrum β-lactam antibiotic which exhibits potent bactericidal activity against Gram-negative bacteria as well as select Gram-positive strains through penicillin-binding proteins. Piperacillin is most commonly used in combination with the β-lactamase inhibitor Tazobactam .
|
-
- HY-B0122S1
-
-
- HY-15670
-
|
γ-secretase
Notch
|
Cancer
|
BMS-906024 is an orally active and selective γ-secretase (gamma secretase) inhibitor. BMS-906024 is a potent pan-Notch receptors inhibitor with IC50s of 1.6 nM, 0.7 nM, 3.4 nM, and 2.9 nM for Notch1, -2, -3, and -4 receptors, respectively. BMS-906024 demonstrates broad-spectrum antineoplastic activity .
|
-
- HY-B0122R
-
McN 4853 (Standard); RWJ 17021 (Standard)
|
Reference Standards
iGluR
GABA Receptor
Sodium Channel
Calcium Channel
Potassium Channel
Carbonic Anhydrase
|
Neurological Disease
|
Topiramate (Standard) is the analytical standard of Topiramate. This product is intended for research and analytical applications. Topiramate (McN 4853) is a broad-spectrum antiepileptic agent. Topiramate is a GluR5 receptor antagonist. Topiramate produces its antiepileptic effects through enhancement of GABAergic activity, inhibition of kainate/AMPA receptors, inhibition of voltage-sensitive sodium and calcium channels, increases in potassium conductance, and inhibition of carbonic anhydrase .
|
-
- HY-B1286R
-
Sodium piperacillin (Standard)
|
Reference Standards
Bacterial
Antibiotic
Penicillin-binding protein (PBP)
|
Infection
|
Piperacillin (sodium) (Standard) is the analytical standard of Piperacillin (sodium). This product is intended for research and analytical applications. Piperacillin sodium is a semisynthetic broad-spectrum β-lactam antibiotic which exhibits potent bactericidal activity against Gram-negative bacteria as well as select Gram-positive strains through penicillin-binding proteins. Piperacillin is most commonly used in combination with the β-lactamase inhibitor Tazobactam .
|
-
- HY-N6625R
-
|
Reference Standards
Fungal
Estrogen Receptor/ERR
|
Infection
|
Chlorothalonil (Standard) is the analytical standard of Chlorothalonil. This product is intended for research and analytical applications. Chlorothalonil is a broad-spectrum foliar fungicide with oral activity. Chlorothalonil can be used to combat fungal diseases in vegetable and crop leaves. Chlorothalonil can alter the microbial community in the soil. Chlorothalonil inhibits spermatogenesis. Chlorothalonil can cause intestinal epithelial barrier dysfunction and fetal toxicity .
|
-
- HY-14926R
-
(S)-(-)-Nadifloxacin (Standard); WCK 771 (Standard)
|
Reference Standards
Antibiotic
Bacterial
|
Infection
|
Levonadifloxacin (Standard) is the analytical standard of Levonadifloxacin. This product is intended for research and analytical applications. Levonadifloxacin ((S)-(-)-Nadifloxacin; WCK 771) is a broad-spectrum anti-staphylococcal agent. Levonadifloxacin shows antibacterial activity against Methicillin (HY-121544)-susceptible Staphylococcus aureus (MSSA) and Methicillin-resistant S. aureus (MRSA) strains, with a reduction of which phagocytized in THP-1 monocytes[1].
|
-
- HY-W015764
-
T-1105
1 Publications Verification
|
Flavivirus
|
Infection
|
T-1105, a structural analogue of T-705, is a novel broad-spectrum viral polymerase inhibitor. T-1105 inhibits the polymerases of RNA viruses after being converted to ribonucleoside triphosphate (RTP) metabolite. T-1105 has antiviral activity against various RNA viruses. T-1105 can be formed by nicotinamide mononucleotide adenylyltransferase .
|
-
- HY-12638R
-
DDM (Standard)
|
Reference Standards
Bacterial
Fungal
Parasite
|
Infection
|
Dichlorophen (Standard) is the analytical standard of Dichlorophen (HY-12638). This product is intended for research and analytical applications. Dichlorophen is a chlorophenol antimicrobial agent that can destroy the integrity of microbial cell membranes and interfere with the activity of metabolic enzymes. Dichlorophen can covalently bind to the thiol groups of microbial proteins and has broad-spectrum antibacterial, antifungal and anthelmintic activity. Dichlorophen can be used as an antimicrobial agent in the study of drug-resistant bacterial infections .
|
-
- HY-B0863
-
|
Apoptosis
Autophagy
Necroptosis
|
Neurological Disease
|
Glyphosate, a non-selective systemic biocide with broad-spectrum activity, is an herbicidal derivative of the amino acid glycine. Glyphosate inhibits the enzymatic activity of the 5-endopyruvylshikimate 3-phosphate synthase (EPSPS) in the shikimic acid pathway, preventing the synthesis of the aromatic amino acids tyrosine, phenylalanine, and tryptophan. Glyphosate induces oxidative stress, neuroinflammation, and mitochondrial dysfunction, processes that lead to neuronal death by autophagia, necrosis, or apoptosis, as well as the appearance of behavioral and motor disorders .
|
-
- HY-138540R
-
|
Fungal
|
Cancer
|
1-Dodecylimidazole (Standard) is the analytical standard of 1-Dodecylimidazole. This product is intended for research and analytical applications. 1-Dodecylimidazole (N-Dodecylimidazole) is a lysosomotropic detergent and a cytotoxic agent. 1-Dodecylimidazole causes cell death by its acid-dependent accumulation in lysosomes, disruption of the lysosomal membrane, and releaseof cysteine proteases into the cytoplasm. 1-Dodecylimidazole has hypocholesterolaemic activity and broad-spectrum antifungal activity .
|
-
- HY-168923
-
|
Enterovirus
|
Infection
|
HR-568 exhibits broad-spectrum anti-enterovirus activity. HR-568 inhibits enterovirus species EV-A71, E30 and CVA24 in cell MRC-5 with EC50 of 1.53 μM, 0.4 μM and 1.22 μM. HR-568 targets hydrophobic canyon pocket on the enterovirus capsid protein, and inhibits the virus replication .
|
-
- HY-124618
-
|
Flavivirus
Dengue Virus
HCV
HIV
|
Infection
|
FGI-106 is a potent and broad-spectrum inhibitor with inhibitory activity against multiple viruses. FGI-106 is active against Ebola, Rift Valley and Dengue Fever viruses with EC50s of 100 nM, 800 nM and 400-900 nM, respectively. FGI-106 also inhibits non-hemorrhagic fever viruses HCV and HIV-1 with EC50s of 200 nM and 150 nM, respectively .
|
-
- HY-124304
-
LOE-908
|
TRP Channel
SARS-CoV
|
Neurological Disease
|
Pinokalant is a broad-spectrum and non-selectivecation channel inhibitor. Pinokalant significantly reduces cortical infarct volume. Pinokalant o improves the metabolic and electrophysiologic status of the ischemic penumbra. Pinokalant reduces lesion size on magnetic resonance images in the acute phase following middle cerebral artery occlusion in rats. Pinokalant has the potential for the research of stroke. Pinokalant also shows anti-SARS-CoV-2 activity .
|
-
- HY-B0536R
-
AM-1091 (Standard); CI-960 (Standard); PD 127391 (Standard)
|
Reference Standards
Bacterial
Antibiotic
|
Infection
|
Clinafloxacin (Standard) is the analytical standard of Clinafloxacin. This product is intended for research and analytical applications. Clinafloxacin (AM 1091) is a potent and broad-spectrum fluoroquinolone antibiotic, has inhibitory activity against gram-positive, gram-negative bacterias, and anaerobic pathogens in vitro . Clinafloxacin is against DNA gyrase and topoisomerase IV of S. aureus with IC50 values of 0.92 µg/ml and 1.62 µg/ml, respectively .
|
-
- HY-176282
-
|
CDK
PI3K
|
Cancer
|
CDK8-IN-19 (Compound 3d) is a CDK8 inhibitor with an IC50 of 25.08 nM. CDK8-IN-19 has a broad-spectrum anticancer activity, such as leukemia, melanoma and breast cancer, without significant cytotoxic effect on the normal Vero cells (mean IC50s of 2.87, 3.65, 3.79 and 45.48 μM, respectively) .
|
-
- HY-10581
-
AM-1155; BMS-206584; PD135432
|
Bacterial
Topoisomerase
Antibiotic
|
Infection
|
Gatifloxacin (AM-1155; BMS-206584; PD135432) is a potent fluoroquinolone antibiotic with broad-spectrum antibacterial activity. Gatifloxacin inhibits bacterial type II topoisomerases (IC50=13.8 μg/ml for S. aureus topoisomerase IV) and E. coli DNA gyrase (IC50=0.109 μg/ml) . Gatifloxacin can be used to treat bacterial conjunctivitis in vivo.
|
-
- HY-116214R
-
CGA-219417 (Standard)
|
Reference Standards
Fungal
Androgen Receptor
Aryl Hydrocarbon Receptor
PERK
Cytochrome P450
|
Infection
Endocrinology
|
Cyprodinil (Standard) (CGA-219417 (Standard)) is the analytical standard of Cyprodinil (HY-116214). This product is intended for research and analytical applications. Cyprodinil (CGA-219417) is a broad-spectrum anilinopyrimidine fungicide and an activator of the aryl hydrocarbon receptor. Cyprodinil also has anti-androgenic and androgenic activities. Cyprodinil can inhibit the biosynthesis of methionine in plant-pathogenic fungi and protect fruits and vegetables from a variety of pathogens.
|
-
- HY-17452
-
ME 1206
|
Beta-lactamase
Bacterial
|
Infection
Inflammation/Immunology
|
Cefditoren sodium (ME 1206) is a broad-spectrum, third-generation, oral cephalosporin antibacterial with enhanced stability against many common β lactamases. Cefditoren sodium has activity against Gram-negative organisms and Gram-positive organisms. Cefditoren sodium can be used in the research of infection diseases such as acute exacerbations of chronic bronchitis, community-acquired pneumonia (CAP), streptococcal pharyngitis/tonsillitis, or uncomplicated skin and skin structure infections .
|
-
- HY-10581C
-
AM-1155 sesquihydrate; BMS-206584 sesquihydrate; PD135432 sesquihydrate
|
Bacterial
Topoisomerase
Antibiotic
|
Infection
Inflammation/Immunology
|
Gatifloxacin sesquihydrate (AM-1155; BMS-206584; PD135432) is a potent fluoroquinolone antibiotic with broad-spectrum antibacterial activity. Gatifloxacin sesquihydrate inhibits bacterial type II topoisomerases (IC50=13.8 μg/ml for S. aureus topoisomerase IV) and E. coli DNA gyrase (IC50 = 0.109 μg/ml) . Gatifloxacin sesquihydrate can be used to treat bacterial conjunctivitis in vivo.
|
-
- HY-B0223
-
-
- HY-107549
-
|
HDAC
|
Cancer
|
KD 5170 is a pan inhibitor of histone deacetylases (HDACs) and exhibits broad spectrum antitumor activity in vitro and in vivo .
|
-
- HY-B0330DS
-
|
Isotope-Labeled Compounds
Bacterial
Antibiotic
|
Infection
|
(R)-Ofloxacin-d3 is the deuterium labeled (R)-Ofloxacin. (R)-Ofloxacin is the dextrorotatory enantiomer of Ofloxacin (HY-B0125) and is an orally effective fluoroquinolone antibiotic. (R)-Ofloxacin can inhibit the activity of bacterial DNA topoisomerase II, interfere with bacterial DNA replication and repair, and exert a bactericidal effect. (R)-Ofloxacin has a broad-spectrum antibacterial activity and has inhibitory effects on both Gram-negative and Gram-positive bacteria .
|
-
- HY-12098R
-
|
Microtubule/Tubulin
|
Cancer
|
Verubulin (hydrochloride) (Standard) is the analytical standard of Verubulin (hydrochloride). This product is intended for research and analytical applications. Verubulin hydrochloride (MPC-6827 hydrochloride) is a blood brain barrier permeable microtubule-disrupting agent, with potent and broad-spectrum in vitro and in vivo cytotoxic activities. Verubulin hydrochloride (MPC-6827 hydrochloride) exhibits potent anticancer activity in human MX-1 breast and other mouse xenograft cancer models. Verubulin hydrochloride (MPC 6827 hydrochloride) is a promising candidate for the treatment of multiple cancer types .
|
-
- HY-128423R
-
Acetylisovaleryltylosin tartrate (Standard)
|
Antibiotic
Bacterial
NF-κB
Reference Standards
Apoptosis
|
Infection
Inflammation/Immunology
|
Tylvalosin (tartrate) (Standard) is the analytical standard of Tylvalosin (tartrate). This product is intended for research and analytical applications. Tylvalosin (Acetylisovaleryltylosin) tartrate is an orally active, broad-spectrum macrolide antibiotic with antimicrobial activity. Tylvalosin tartrate is an antiviral agent useful in studying PRRSV infection. Tylvalosin tartrate induces apoptosis. Tylvalosin tartrate also has anti-inflammatory activity, relieves oxidative stress, and alleviates acute lung injury by inhibiting NF-κB activation [4].
|
-
- HY-B2041
-
|
Insecticide
|
Infection
|
Benfuracarb is a broad-spectrum carbamate insecticide with crop protection activity. Benfuracarb is used to control springtails, aphids, and other pests, typically on sugar beet crops. Benfuracarb exhibits toxicity to humans and aquatic organisms. Benfuracarb exposure to zebrafish embryos resulted in a reduction in the body length of zebrafish larvae. Superoxide dismutase (SOD) activity was significantly increased after Benfuracarb treatment. Benfuracarb also interfered with the transcriptional levels of marker genes associated with early embryonic development .
|
-
- HY-14904R
-
|
Reference Standards
SARS-CoV
Influenza Virus
CHIKV
|
Infection
|
Umifenovir (Standard) is the analytical standard of Umifenovir. This product is intended for research and analytical applications. Umifenovir is a potent, orally active broad-spectrum antiviral agent with activity against a number of enveloped and non-enveloped viruses. Umifenovir is used as an anti-influenza virus agent. Umifenovir could effectively inhibit the fusion of virus with host cells . Umifenovir is an efficient inhibitor of SARS-CoV-2 in vitro . Umifenovir shows anti-inflammatory activity .
|
-
- HY-13678S1
-
SM 7338-d6-1
|
Bacterial
Antibiotic
|
Infection
|
Meropenem-d6-1 (SM 7338-d6-1) is the deuterium labeled Meropenem. Meropenem (SM 7338) is a carbapenem antibiotic with broad-spectrum antibacterial activity. Meropenem has activity against susceptible and resistant N. gonorrhoeae (MIC value of 0.02-0.06 mg/mL), H. influenzae (MIC value of 0.03-0.12 mg/mL), and H. ducreyi (MIC value of 0.015-0.12 mg/mL) .
|
-
- HY-B0863B
-
|
Apoptosis
Autophagy
Necroptosis
|
Neurological Disease
|
Glyphosate isopropylammonium, a non-selective systemic biocide with broad-spectrum activity, is an herbicidal derivative of the amino acid glycine. Glyphosate isopropylammonium inhibits the enzymatic activity of the 5-endopyruvylshikimate 3-phosphate synthase (EPSPS) in the shikimic acid pathway, preventing the synthesis of the aromatic amino acids tyrosine, phenylalanine, and tryptophan. Glyphosate isopropylammonium induces oxidative stress, neuroinflammation, and mitochondrial dysfunction, processes that lead to neuronal death by autophagia, necrosis, or apoptosis, as well as the appearance of behavioral and motor disorders .
|
-
- HY-13678AR
-
SM 7338 trihydrate (Standard)
|
Penicillin-binding protein (PBP)
Reference Standards
Bacterial
Antibiotic
|
Infection
Cancer
|
Meropenem (trihydrate) (Standard) is the analytical standard of Meropenem (trihydrate). This product is intended for research and analytical applications. Meropenem trihydrate (SM 7338 trihydrate) is a carbapenem antibiotic with broad-spectrum antibacterial activity. Meropenem trihydrate has activity against susceptible and resistant N. gonorrhoeae (MIC value of 0.02-0.06 mg/mL), H. influenzae (MIC value of 0.03-0.12 mg/mL), and H. ducreyi (MIC value of 0.015-0.12 mg/mL) .
|
-
- HY-13986
-
-
- HY-B0798
-
SM-1652; Wy-44635
|
Bacterial
Antibiotic
|
Infection
|
Cefpiramide sodium (SM-1652; Wy-44635) is a new Pseudomonas-active cephalosporin with a broad spectrum of antibacterial activity.
|
-
- HY-101128
-
FR2054
|
Bacterial
Antibiotic
|
Infection
|
Bicyclomycin benzoate is an antibiotic exhibiting activity against a broad spectrum of Gram-negative bacteria and against the Gram-positive bacterium.
|
-
- HY-113735
-
|
Bacterial
Antibiotic
|
Infection
|
Cephapirin Benzathine is the benzathine salt form of cephapirin. Cephapirin Benzathine is the first generation cephalosporin with broad spectrum antibiotic activity .
|
-
- HY-A0269
-
Amdinocillin; FL 1060
|
Bacterial
Antibiotic
|
Infection
|
Mecillinam (Amdinocillin), the β-lactam antibiotic, has a broad spectrum of activity against gram-negative organisms .
|
-
- HY-122470
-
|
Reverse Transcriptase
HIV
|
Infection
|
Stampidine is a nucleoside reverse transcriptase inhibitor (NRTI) with potent and broad-spectrum anti-HIV activity. Stampidine inhibits the laboratory HIV-1 strain HTLVIIIB (B-envelope subtype) and primary clinical isolates with IC50s of 1 nM and 2 nM, respectively. Stampidine also inhibits NRTI-resistant primary clinical isolates and NNRTI-resistant clinical isolates with IC50s of 8.7 nM and 11.2 nM, respectively .
|
-
- HY-B1190
-
BL-S 578
|
Bacterial
Antibiotic
EAAT
|
Infection
Neurological Disease
|
Cefadroxil is an orally active broad-spectrum cephalosporin antibiotic. Cefadroxil inhibits bacterial cell wall synthesis and enhances the expression of glutamate transporter-1. Cefadroxil is dependent on the intestinal peptide transporter PepT1 for small intestinal absorption. Cefadroxil has inhibitory and bactericidal activity against a variety of Gram-positive and Gram-negative bacteria and has analgesic effects on neuropathic pain .
|
-
- HY-B0778R
-
|
Reference Standards
Antibiotic
Parasite
|
Infection
|
Milbemycin oxime (Standard) is the analytical standard of Milbemycin oxime. This product is intended for research and analytical applications. Milbemycin oxime is an orally active macrolide with broad-spectrum antiparasitic activity. Milbemycin oxime is a mixture of oximes consisting of oxime derivatives corresponding to milbemycin A4 and A3. Milbemycin oxime binds to glutamate-gated chloride channels and has inhibitory potency against intestinal nematodes and lung/heart worms .
|
-
- HY-B1190A
-
BL-S 578 hydrate
|
Bacterial
Antibiotic
EAAT
|
Infection
Neurological Disease
|
Cefadroxil hydrate is an orally active broad-spectrum cephalosporin antibiotic. Cefadroxil hydrate inhibits bacterial cell wall synthesis and enhances the expression of glutamate transporter-1. Cefadroxil hydrate is dependent on the intestinal peptide transporter PepT1 for small intestinal absorption. Cefadroxil hydrate has inhibitory and bactericidal activity against a variety of Gram-positive and Gram-negative bacteria and has analgesic effects on neuropathic pain .
|
-
- HY-161342
-
|
Cathepsin
SARS-CoV
|
Infection
Inflammation/Immunology
|
CTSL/CAPN1-IN-2 (Compound 14b) is an orally active inhibitor of both CTSL and CAPN1, with IC50 values of 6.88 nM and 347.6 nM, respectively. CTSL/CAPN1-IN-2 possesses anti-inflammatory properties and favorable pharmacokinetic characteristics. CTSL/CAPN1-IN-2 exhibits broad-spectrum antiviral activity against coronaviruses by blocking viral entry .
|
-
- HY-112579
-
Ro 63-9141; BAL 9141
|
Bacterial
Antibiotic
|
Infection
Inflammation/Immunology
|
Ceftobiprole (Ro 63-9141) is a broad-spectrum cephalosporin with high levels of in vitro activity against methicillin- (MRSA) and vancomycin-resistant staphylococci (VRSA) and penicillin-resistant streptococci with a MIC90 value of 2 μg/mL for MRSA. Ceftobiprole also inhibits gram-positive and gram-negative pathogens. Ceftobiprole can be used for the study of hospital-acquired pneumonia (excluding ventilator-associated pneumonia) and community-acquired pneumonia .
|
-
- HY-146165
-
|
Beta-lactamase
Bacterial
|
Infection
|
Metallo-β-lactamase-IN-8 (compound 17) is a potent, reversible and competitive broad-spectrum inhibitor of metallo-β-lactamases (MβLs), with IC50s of 1.3 μM, 5.7 μM, 9.8 μM, and 9.9 μM for L1, ImiS, IMP-1 and VIM-2, respectively. Metallo-β-lactamase-IN-8 exhibits antibacterial activity .
|
-
- HY-P99189
-
IMC-A12; NSC742460
|
IGF-1R
|
Cancer
|
Cixutumumab (IMC-A12) is a human anti-IGF-1R monoclonal antibody with high affinity that inhibits ligand-dependent receptor activation and downstream signaling. Cixutumumab also mediates the internalization and degradation of IGF-IR. Cixutumumab shows broad-spectrum anti-tumour activity and can be used in studies of cancers such as lung cancer, malignancies, leukaemia, non-small cell lung cancer and prostate cancer .
|
-
- HY-168210
-
|
Fungal
Cytochrome P450
|
Infection
|
Antifungal agent 122 (compound 201) is a potent and broad-spectrum antifungal agent. Antifungal agent 122 prevents fungal phase transition and the formation of fungal biofilm. Antifungal agent 122 inhibits CYP3A4-M and CYP3A4-T enzyme activity with IC50 values of 2.11, 4.53 µM. Antifungal agent 122 shows no cytotoxicity .
|
-
- HY-116214S
-
-
- HY-15096
-
FJ-776
|
Fluorescent Dye
HSP
|
Cancer
|
MKT-077 (FJ-776), a highly water-soluble mitochondrial dye, has significant antitumor activity . MKT-077 exhibits low cytotoxicity, and inhibits broad-spectrum human cancer cell lines (colon cancer, breast cancer, pancreatic cancer). MKT-077 inhibits the growth of tumor in nude mice enograft tumor model. Ex/Em=488/543 nm .
|
-
- HY-A0035
-
|
Antibiotic
Bacterial
|
Infection
|
Faropenem is a potent and orally active beta-lactam antibiotic. Faropenem demonstrates broad-spectrum in vitro antimicrobial activity against many gram-positive and -negative aerobes and anaerobes. Faropenem is resistant to hydrolysis by nearly all beta-lactamases, including extended-spectrum beta-lactamases and AmpC beta-lactamases. Faropenem is developed as an oral proagent, faropenem medoxomil, for the research of respiratory tract infections .
|
-
- HY-B1080R
-
|
Reference Standards
HIF/HIF Prolyl-Hydroxylase
Influenza Virus
|
Infection
Neurological Disease
|
Tilorone (dihydrochloride) (Standard) is the analytical standard of Tilorone (dihydrochloride). This product is intended for research and analytical applications. Tilorone dihydrochloride is an orally active interferon (IFN) inducer with broad-spectrum antiviral activities. Tilorone dihydrochloride possesses robust anti-Severe fever with thrombocytopenia syndrome virus (SFTSV) activity in vitro and in vivo through stimulation of host innate immunity. Tilorone dihydrochloride can penetrate the blood-brain barrier to activate HIF in the CNS .Tilorone dihydrochloride exhibits an inhibitory activity with EC50 of 230 nM against Ebola virus (EBOV) .
|
-
- HY-B0210S
-
-
- HY-N1950
-
Dinatin
|
Pim
|
Cancer
|
Hispidulin is a natural flavone with a broad spectrum of biological activities. Hispidulin is a Pim-1 inhibitor with an IC50 of 2.71 μM.
|
-
- HY-B0272
-
-
- HY-B1599
-
|
Bacterial
Antibiotic
|
Infection
|
Chloramphenicol palmitate is an orally active broad spectrum antibiotic and has a broad spectrum of activity against gram positive and gram negative bacteria. Chloramphenicol palmitate inhibits bacterial protein synthesis by blocking the peptidyl transferase step. Chloramphenicol palmitate can be used as bacterial selection agent in transformed cells containing chloramphenicol resistance genes .
|
-
- HY-118326
-
|
Autophagy
|
Cancer
|
MRT 68601 is a potent TBK1 inhibitor with the activity of inhibiting autophagosome formation in lung cancer cells. MRT 68601 may have potential effects against targets associated with host-dependent factors identified in SARS-CoV-2 infection. The drug targets involved in MRT 68601 are related to existing FDA-approved drugs and compounds in clinical trials, which can provide support for the development of broad-spectrum antiviral therapies .
|
-
- HY-12596
-
|
Calcium Channel
Sodium Channel
Potassium Channel
|
Neurological Disease
|
JNJ-26489112, a CNS-active agent, exhibits broad-spectrum anticonvulsant activity in rodents against audiogenic, electrically-induced, and chemically-induced seizures. JNJ-26489112 inhibits voltage-gated Na + channels and N-type Ca 2+ channels, and is effective as a K + channel opener. JNJ-26489112 has very weak inhibition of CA-II (IC50=35 μM) and CA-I (18 μM) .
|
-
- HY-139663
-
|
Glycosidase
|
Infection
|
IHVR-17028 is a potent and broad-spectrum antiviral agent. IHVR-17028 exhibits antiviral activity against BVDV, TCRV and DENV with EC50 values of 0.4 μM, 0.26 μM, 0.3 μM, respectively. IHVR-17028 is a potent ER α-glucosidase I inhibitor with an IC50 of 0.24 μM. IHVR-17028 can be used for infectious diseases research .
|
-
- HY-116214S1
-
-
- HY-128718
-
|
Influenza Virus
|
Infection
|
Carbodine (Carbocyclic cytidine) is a broad-spectrum antiviral agent active against DNA viruses, (+)RNA viruses, (-)RNA viruses, paramyxo, rhabdo and (+/-)RNA viruses, targets CTP synthetase that converts UTP to CTP. Carbodine (Carbocyclic cytidine) possesses significant antiviral activity against influenza virus types A0/PR-8/34 and A2/Aichi/2/68 in vitro .
|
-
- HY-150625
-
|
SARS-CoV
|
Infection
|
SARS-CoV-2 nsp13-IN-4 (C4 (d)) is a potent and selective nsp13 helicase small-molecule inhibitor and inhibit the ssDNA+ ATPase activity of nsp13 with an IC50 value of 57 μM. SARS-CoV-2 nsp13-IN-4 is agentlike molecule with molecular weight of less than 450Da and can provide a broad-spectrum antiviral effect .
|
-
- HY-B1075AS
-
MK-0955 (benzylamine)-13C3
|
Bacterial
Antibiotic
|
Infection
|
(Rac)-Fosfomycin (benzylamine)- 13C3 is the 13C labeled Fosfomycin . Fosfomycin (MK-0955) is a broad-spectrum antibiotic. Fosfomycin can cross blood-brain barrier penetrating, and irreversibly inhibits an early stage in cell wall synthesis. Fosfomycin shows anti-bacteria activity for a range of bacteria, including multidrug-resistant (MDR), extensively drug-resistant (XDR), and pan-drug-resistant (PDR) bacteria .
|
-
- HY-17452A
-
Cefditoren pivoxyl; Cefditoren pivaloyloxymethyl ester; ME 1207
|
Beta-lactamase
Bacterial
Antibiotic
|
Infection
Inflammation/Immunology
|
Cefditoren Pivoxil (ME 1207) is a broad-spectrum, third-generation, oral cephalosporin antibacterial with enhanced stability against many common β lactamases. Cefditoren Pivoxil has activity against Gram-negative organisms and Gram-positive organisms. Cefditoren Pivoxil can be used in the research of infection diseases such as acute exacerbations of chronic bronchitis, community-acquired pneumonia (CAP), streptococcal pharyngitis/tonsillitis, or uncomplicated skin and skin structure infections .
|
-
- HY-B1257R
-
Sodium cefmetazole (Standard)
|
Reference Standards
Bacterial
Antibiotic
|
Infection
Cancer
|
Cefmetazole (sodium) (Standard) is the analytical standard of Cefmetazole (sodium). This product is intended for research and analytical applications. Cefmetazole sodium (Sodium cefmetazole) is a semisynthetic cephamycin antibiotic with broad-spectrum antibacterial activity, covering gram-positive, gram-negative, and anaerobic bacteria. Cefmetazole sodium binds to penicillin binding proteins (PBPs), resulting in interfering bacterial cell wall biosynthesis. Cefmetazole sodium is used for the research of gynecologic, intraabdominal, urinary tract, respiratory tract and skin and soft tissue infections .
|
-
- HY-155545
-
|
Fungal
|
Infection
|
Antifungal agent 60 (compound 16) is an inhibitor of ergosterol biosynthesis with broad-spectrum antifungal activity. Antifungal agent 60 inhibits 7 human pathogenic fungal species, 2 fluconazole-resistant C. albicans isolates and 2 multi-drug resistant Candida auris isolates. Antifungal agent 60 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-A0086R
-
SCH-20569 sulfate (Standard)
|
Reference Standards
Bacterial
Antibiotic
|
Infection
|
Netilmicin sulfate (Standard) is the analytical standard of Netilmicin sulfate (HY-A0086). This product is intended for research and analytical applications. Netilmicin (Sch 20569) sulfate is a broad-spectrum semisynthetic aminoglycoside antibiotic. Netilmicin sulfate exhibits antibacterial activity against aminoglycoside-susceptible gram-negative strains and aminoglycoside-resistant strain, such as Escherichia coli, Pseudomonas aeruginosa, Proteus, Staphylococcus aureus, Streptococcus, Serratia, and Enterobacter, with MIC of 0.125-8 μg/mL .
|
-
- HY-144113
-
|
HIV
|
Infection
|
HIV-1 inhibitor-14 (compound 14b) is a highly potent and broad-spectrum HIV-1 non-nucleoside reverse transcriptase (RT) inhibitor with an EC50 of 0.14 μM for HIV-1 RT. HIV-1 inhibitor-14 has inhibitory activity against HIV-1 WT and resistant strains with EC50s of 5.79 ~ 28.3 nM .
|
-
- HY-17452B
-
Cefditoren pivoxyl hydrochloride; Cefditoren pivaloyloxymethyl ester hydrochloride; ME 1207 hydrochloride
|
Beta-lactamase
Bacterial
Antibiotic
|
Infection
Inflammation/Immunology
|
Cefditoren Pivoxil (ME 1207) hydrochloride is a broad-spectrum, third-generation, oral cephalosporin antibacterial with enhanced stability against many common β lactamases. Cefditoren Pivoxil has activity against Gram-negative organisms and Gram-positive organisms. Cefditoren Pivoxil can be used in the research of infection diseases such as acute exacerbations of chronic bronchitis, community-acquired pneumonia (CAP), streptococcal pharyngitis/tonsillitis, or uncomplicated skin and skin structure infections .
|
-
- HY-P3906
-
|
Fungal
Apoptosis
Phospholipase
Reactive Oxygen Species (ROS)
|
Infection
|
Melittin free acid is a basic 26-amino-acid polypeptide, the major active ingredient of honeybee venom. Melittin free acid is an activator of phospholipase A2 (PLA2). Melittin free acid has broad-spectrum antifungal activity with MIC values of 0.4-60 μM. Melittin free acid hinders fungal growth by inducing cell apoptosis, repressing (1,3)-β-D-glucan synthase and participating in other pathways .
|
-
- HY-10581AS
-
AM-1155-d3 hydrochloride; BMS-206584-d3 hydrochloride; PD135432-d3 hydrochloride
|
Isotope-Labeled Compounds
Bacterial
Topoisomerase
Antibiotic
|
Infection
|
Gatifloxacin-d3 (hydrochloride) is the deuterium labeled Gatifloxacin (hydrochloride). Gatifloxacin hydrochloride (AM-1155; BMS-206584; PD135432) is a potent fluoroquinolone antibiotic with broad-spectrum antibacterial activity. Gatifloxacin hydrochloride inhibits bacterial type II topoisomerases (IC50=13.8 μg/ml for S. aureus topoisomerase IV) and E. coli DNA gyrase (IC50 = 0.109 μg/ml). Gatifloxacin hydrochloride can be used to treat bacterial conjunctivitis in vivo.
|
-
- HY-124618A
-
|
Flavivirus
Dengue Virus
HCV
HIV
|
Infection
|
FGI-106 tetrahydrochloride is a potent and broad-spectrum inhibitor with inhibitory activity against multiple viruses. FGI-106 tetrahydrochloride is active against Ebola, Rift Valley and Dengue Fever viruses with EC50s of 100 nM, 800 nM and 400-900 nM, respectively. FGI-106 tetrahydrochloride also inhibits non-hemorrhagic fever viruses HCV and HIV-1 with EC50s of 200 nM and 150 nM, respectively .
|
-
- HY-B1064
-
Clindamycin 2-phosphate; U-28508
|
Bacterial
Antibiotic
Parasite
|
Infection
Cancer
|
Clindamycin phosphate (Clindamycin 2-phosphate) is a broad-spectrum bacteriostatic lincosamide antibiotic. Clindamycin phosphate is the proagent of Clindamycin (HY-B1455) with no antimicrobial activity in vitro but can be rapidly converted in vivo to the active parent agent, Clindamycin, by phosphatase ester hydrolysis. Clindamycin phosphate can be used for researching acne and bacterial vaginosis .Clindamycin phosphate has no cytotoxicity. Combined with platelet rich fibrin (PRF), PRF-Clindamycin phosphate enhances antimicrobial properties .
|
-
- HY-162701
-
|
SARS-CoV
Influenza Virus
RSV
HSV
|
Infection
|
Antiviral agent 58 (Compound J1) is an orally active antiviral agent with broad-spectrum antiviral activity against enveloped viruses, including influenza A virus (IAV), respiratory syncytial virus (RSV), severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), human coronavirus OC43 (HCoV-OC43), herpes simplex virus type 1 (HSV-1), and HSV-2 .
|
-
- HY-169021
-
|
JNK
|
Cancer
|
JNK-1-IN-3 (Compound 9e) is an inhibitor of JNK1 that downregulates JNK1 gene expression and inhibits the protein levels of its phosphorylated form, concurrently reducing the expression of its downstream targets, c-Jun and c-Fos, in tumors while restoring p53 activity. JNK-1-IN-3 exhibits broad-spectrum antiproliferative activity, particularly with high inhibitory activity against renal and breast cancer cell lines, demonstrating both in vivo and in vitro anticancer activity .
|
-
- HY-N13961
-
XK-88-2
|
Antibiotic
Bacterial
|
Infection
|
Seldomycin factor 2 (XK 88-2) is an aminoglycoside antibiotic. Seldomycin factor 2 has a broad spectrum of antimicrobial activity .
|
-
- HY-N13964
-
XK 88-3
|
Antibiotic
Bacterial
|
Infection
|
Seldomycin factor 3 (XK 88-3) is an aminoglycoside antibiotic. Seldomycin factor 3 has a broad spectrum of antimicrobial activity .
|
-
- HY-N13986
-
XX-88-5
|
Antibiotic
Bacterial
|
Infection
|
Seldomycin factor 5 (XK 88-5) is an aminoglycoside antibiotic. Seldomycin factor 5 has a broad spectrum of antimicrobial activity .
|
-
- HY-N13959
-
XK 88-1
|
Antibiotic
Bacterial
|
Infection
|
Seldomycin factor 1 (XK 88-1) is an aminoglycoside antibiotic. Seldomycin factor 1 has a broad spectrum of antimicrobial activity .
|
-
- HY-B1050R
-
SB-265805S (Standard); LB-20304a (Standard)
|
Reference Standards
Bacterial
Antibiotic
DNA/RNA Synthesis
Topoisomerase
|
Infection
|
Gemifloxacin (mesylate) (Standard) is the analytical standard of Gemifloxacin (mesylate). This product is intended for research and analytical applications. Gemifloxacin mesylate (SB-265805S; LB-20304a) is an orally active broad-spectrum quinolone antibacterial antibiotic. Gemifloxacin mesylate inhibits DNA synthesis by inhibiting DNA gyrase and Topoisomerase IV activities. Gemifloxacin mesylate has potent antibacterial activities against gram-positive bacteria in vitro efficacy study, particularly Streptococci and Staphylococci. Gemifloxacin mesylate has been used in the research of respiratory tract infections .
|
-
- HY-B0319
-
UK-20349
|
Fungal
Antibiotic
Parasite
Akt
PI3K
mTOR
Autophagy
|
Infection
Cancer
|
Tioconazole (UK-20349) is a broad-spectrum antifungal imidazole derivative. Tioconazole inhibits several dermatophytes and yeasts, with MIC50 values of less than 3.12 mg/L and 9 mg/L, respectively. Additionally, Tioconazole exhibits anti-parasitic activity. Tioconazole exerts anticancer activity by inhibiting the PI3K/AKT/mTOR signaling pathway and blocking autophagy. Tioconazole is applicable for research in the fields of anti-infection and anticancer therapy .
|
-
- HY-B0330DR
-
Dextrofloxacin (Standard)
|
Reference Standards
Bacterial
Antibiotic
|
Infection
|
(R)-Ofloxacin (Standard) is the analytical standard of (R)-Ofloxacin (HY-B0330D). (R)-Ofloxacin is the dextrorotatory enantiomer of Ofloxacin (HY-B0125) and is an orally effective fluoroquinolone antibiotic. (R)-Ofloxacin can inhibit the activity of bacterial DNA topoisomerase II, interfere with bacterial DNA replication and repair, and exert a bactericidal effect. (R)-Ofloxacin has a broad-spectrum antibacterial activity and has inhibitory effects on both Gram-negative and Gram-positive bacteria .
|
-
- HY-109035
-
SB9200; GS-9992
|
HCV
HBV
|
Infection
|
Inarigivir soproxil (SB9200) is an agonist of innate immunity and shows potent antiviral activity against resistant HCV variants, with EC50s of 2.2 and 1.0 μM for HCV 1a/1b in cells of genotype 1 HCV replicon systems. Inarigivir soproxil, an orally bioavailable proagent of SB 9000, has broad-spectrum antiviral activity against RNA viruses including HCV, norovirus, respiratory syncytial virus and influenza and HBV .
|
-
- HY-A0170
-
|
Bacterial
Topoisomerase
Antibiotic
|
Infection
|
Trovafloxacin is a broad-spectrum quinolone antibiotic with potent activity against Gram-positive, Gram-negative and anaerobic organisms. Trovafloxacin blocks the DNA gyrase and topoisomerase IV activity. Trovafloxacin is also a potent, selective and orally active pannexin 1 channel (PANX1) inhibitor with an IC50 of 4 μM for PANX1 inward current. Trovafloxacin does not inhibit connexin 43 gap junction or PANX2. Trovafloxacin leads to dysregulated fragmentation of apoptotic cells by inhibiting PANX1 .
|
-
- HY-103399
-
|
Bacterial
Topoisomerase
Antibiotic
|
Infection
|
Trovafloxacin mesylate is a broad-spectrum quinolone antibiotic with potent activity against Gram-positive, Gram-negative and anaerobic organisms. Trovafloxacin mesylate blocks the DNA gyrase and topoisomerase IV activity. Trovafloxacin mesylate is also a potent, selective and orally active pannexin 1 channel (PANX1) inhibitor with an IC50 of 4 μM for PANX1 inward current. Trovafloxacin mesylate does not inhibit connexin 43 gap junction or PANX2. Trovafloxacin mesylate leads to dysregulated fragmentation of apoptotic cells by inhibiting PANX1 .
|
-
- HY-175245
-
|
Carbonic Anhydrase
|
Cancer
|
hCA-IN-1 (Compound 5u) is an hCA inhibitor with Ki values of 159.2, 4.8, 15.5, and 2 nM against hCA I, hCA II, hCA IX, and hCA XII, respectively. hCA-IN-1 exhibits broad-spectrum anticancer activity against melanoma, breast, and colon cancer cells. ADME predictions indicate that hCA-IN-1 has good solubility and oral bioavailability. hCA-IN-1 can be used in tumor research .
|
-
- HY-176281
-
|
PI3K
CDK
|
Cancer
|
PI3Kα-IN-26 (Compound 11e) is a PI3Kα inhibitor with an IC50 of 75.31 nM. PI3Kα-IN-26 has a broad-spectrum anticancer activity, such as leukemia, colon and breast cancer, without significant cytotoxic effect on the normal Vero cells (mean IC50s of 2.74, 3.50, 3.34 and 85.29 μM, respectively) .
|
-
- HY-155458
-
|
PARP
|
Inflammation/Immunology
Cancer
|
HYDAMTIQ is a PARP-1/2 inhibitor (IC50: 29-38 nM) with anticancer, anti-inflammatory, and ischemic protective effects. HYDAMTIQ inhibits pulmonary PARP activity, is effective against allergen-induced cough and dyspnea, and inhibits bronchial hyperresponsiveness to methacholine. HYDAMTIQ has broad-spectrum tumor suppressor effects, including ovarian and breast cancers, prostate and pancreatic tumors, and glioblastoma multiforme. HYDAMTIQ has demonstrated in vivo efficacy in animal models of cerebral ischemia, asthma, cancer, and more .
|
-
- HY-10581AR
-
AM-1155 hydrochloride (Standard); BMS-206584 hydrochloride (Standard); PD135432 hydrochloride (Standard)
|
Reference Standards
Bacterial
Topoisomerase
Antibiotic
|
Infection
|
Gatifloxacin (hydrochloride) (Standard) is the analytical standard of Gatifloxacin (hydrochloride). This product is intended for research and analytical applications. Gatifloxacin hydrochloride (AM-1155; BMS-206584; PD135432) is a potent fluoroquinolone antibiotic with broad-spectrum antibacterial activity. Gatifloxacin hydrochloride inhibits bacterial type II topoisomerases (IC50=13.8 μg/ml for S. aureus topoisomerase IV) and E. coli DNA gyrase (IC50 = 0.109 μg/ml)[1]. Gatifloxacin hydrochloride can be used to treat bacterial conjunctivitis in vivo.
|
-
- HY-B0736AR
-
FI7056 (Standard)
|
Reference Standards
Fungal
Autophagy
Apoptosis
p38 MAPK
Microtubule/Tubulin
|
Infection
|
Sertaconazole (nitrate) (Standard) is the analytical standard of Sertaconazole (nitrate). This product is intended for research and analytical applications. Sertaconazole nitrate (FI7056) is a broad-spectrum topical antifungal agent, exhibits anti-inflammatory activity via activation of a p38-COX-2-PGE2 pathway. Sertaconazole nitrate is also a microtubule inhibitor, shows antiproliferative effect, induces apoptosis and autophagy, and can also inhibit the migration of cells .
|
-
- HY-B0455
-
SC47111A hydrochloride; NY-198 hydrochloride
|
Antibiotic
Bacterial
Topoisomerase
Reactive Oxygen Species (ROS)
Apoptosis
|
Infection
Endocrinology
Cancer
|
Lomefloxacin hydrochloride (NY-198 hydrochloride) is an orally active difluoroquinolone antibiotic. Lomefloxacin hydrochloride prevents DNA supercoiling and replication by inhibiting bacterial topoisomerase II. Lomefloxacin hydrochloride induces ROS production and Apoptosis. Lomefloxacin hydrochloride has broad-spectrum bactericidal activity against Gram-positive and Gram-negative bacteria. Lomefloxacin hydrochloride has anticancer effects against melanoma. Lomefloxacin hydrochloride can be used in the study of systemic bacterial infections (such as Salmonella typhimurium infections), skin and melanoma .
|
-
- HY-174452
-
-
- HY-107801R
-
Imunovir (Standard); Delimmun (Standard); Groprinosin (Standard); (Standard)
|
Reference Standards
Interleukin Related
HSV
HIV
HPV
|
Infection
Inflammation/Immunology
|
Inosine pranobex (Standard) is the analytical standard of Inosine pranobex. This product is intended for research and analytical applications. Inosine pranobex is an orally active immunomodulator. Inosine pranobex has broad-spectrum antiviral activity. Inosine pranobex inhibits human immunodeficiency virus (HIV), herpes simplex virus (HSV), vaccinia virus (VACV), human tumor virus (HPV), Cytomegalovirus, influenza virus (INFV), parainfluenza virus (PIV), and Epstein-Barr virus .
|
-
- HY-145048
-
|
SOS1
Ras
|
Cancer
|
SOS1-IN-5 is a potent inhibitor of SOS1. SOS1-IN-5 is a pyrimidobicyclic derivative. SOS1-IN-5 blocks the activation of KRAS by interfering with RAS-SOS1 interaction, and achieves the purpose of broad-spectrum inhibition of KRAS activity. SOS1-IN-5 has the potential for the research of cancer diseases (extracted from patent WO2021203768A1, compound 4) .
|
-
- HY-135960
-
|
FGFR
Apoptosis
|
Cancer
|
BO-264 is a highly potent and orally active transforming acidic coiled-coil 3 (TACC3) inhibitor with an IC50 of 188 nM and a Kd of 1.5 nM. BO-264 specifically blocks the function of FGFR3-TACC3 fusion protein. BO-264 induces spindle assembly checkpoint (SAC)-dependent mitotic arrest, DNA damage and apoptosis. BO-264 has broad-spectrum antitumor activity .
|
-
- HY-128932R
-
MT-141 (Standard)
|
Reference Standards
Antibiotic
Bacterial
PPAR
Prostaglandin Receptor
PTEN
Akt
mTOR
|
Infection
Cardiovascular Disease
Endocrinology
|
Cefminox (sodium) (MT-141) (Standard) is the analytical standard of Cefminox (sodium). This product is intended for research and analytical applications. Cefminox sodium is a semisynthetic cephamycin, which exhibits antibacterial activity. Cefminox sodium is a broad-spectrum, bactericidal cephalosporin antibiotic. Cefminox sodium also acts as a dual agonist of prostacyclin receptor (IP) and PPARγ. Cefminox sodium upregulates cAMP production and PTEN expression and inhibits Akt/mTOR signaling. Cefminox sodium also prevents pulmonary arterial hypertension in rat model .
|
-
- HY-151630
-
|
Carbonic Anhydrase
|
Cancer
|
hCAIX-IN-16 (Compound 12d) is hCA IX inhibitor, with Ki values of 190.0 and 187.9 nM for hCA IX and hCA XII, respectively. hCAIX-IN-16 can arrest the cell cycle of breast cancer MDA-MB-468 in G0-G1 and S phase and induce apoptosis. hCAIX-IN-16 shows good broad-spectrum anticancer activity and can be used for cancer research .
|
-
- HY-14879D
-
AVE1330A
|
Bacterial
|
Infection
|
ent-Avibactam sodium (AVE1330A) is a new β-lactamase inhibitor with broad-spectrum antibacterial activity. ent-Avibactam sodium, in combination with ceftazidime, exhibits significant inhibitory effects on Enterobacteriaceae that produce Ambler class A and class C beta-lactamases. The IC50 value of ent-Avibactam sodium is much lower than the commonly used β-lactamase inhibitors clavulanic acid and ticarbonitrile, showing its ability to inhibit TEM-1 and P99 enzyme efficiency .
|
-
- HY-108462
-
ML-SA1
3 Publications Verification
|
Dengue Virus
TRP Channel
Flavivirus
|
Infection
|
ML-SA1, as a selective TRPML agonist, inhibits Dengue virus 2 (DENV2) and Zika virus (ZIKV) by promoting lysosomal acidification and protease activity. The IC50 value of ML-SA1 against DENV2 RNA and ZIKV RNA is 8.3 μM and 52.99 μM, respectively. ML-SA1 induces autophagy. ML-SA1 can be used for the research of broad-spectrum antiviral .
|
-
- HY-B1075R
-
MK-0955 calcium (Standard)
|
Reference Standards
Bacterial
Antibiotic
|
Infection
Cancer
|
Fosfomycin (calcium) (Standard) is the analytical standard of Fosfomycin (calcium). This product is intended for research and analytical applications. Fosfomycin (MK-0955) calcium is a blood-brain barrier penetrating, broad-spectrum antibiotic by irreversibly inhibiting an early stage in cell wall synthesis. Fosfomycin calcium shows both in vivo and in vitro activity against a wide range of bacteria, including multidrug-resistant (MDR), extensively drug-resistant (XDR), and pan-drug-resistant (PDR) bacteria .
|
-
- HY-B0467AS
-
-
- HY-B0467S
-
-
- HY-123047
-
-
- HY-W019852R
-
|
Reference Standards
Fungal
|
Infection
|
Flutriafol (Standard) is the analytical standard of Flutriafol. This product is intended for research and analytical applications. Flutriafol is a triazole fungicide with broad spectrum fungicidal activity.
|
-
- HY-133704
-
|
Bacterial
Fungal
Antibiotic
|
Infection
|
Pyrrolnitrin is an antibiotic isolated from Pseudomonas pyrrocinia. Pyrrolnitrin shows a broad spectrum of antibiotic activity against fungi, yeast and gram-positive bacteria .
|
-
- HY-114551
-
Racemomycin C; Antibiotic S15-1B
|
Bacterial
Fungal
|
Infection
|
Racemomycin C has broad spectrum antibacterial activity and antifungal effect, and it can inhibit PR-8 of influenza virus in tissue culture .
|
-
- HY-B0210R
-
|
Reference Standards
Bacterial
Antibiotic
|
Infection
|
Cefoperazone (Standard) is the analytical standard of Cefoperazone. This product is intended for research and analytical applications. Cefoperazone, a semisynthetic cephalosporin, has a broad spectrum of antibacterial activity .
|
-
- HY-10824B
-
PT523 ammonium
|
Dihydrofolate reductase (DHFR)
Antifolate
|
Cancer
|
Talotrexin ammonium is a nonpolyglutamatable antifolate. Talotrexin ammonium improves antitumor activity in a broad spectrum of cancer models by targeting DHFR to inhibit tumor growth .
|
-
- HY-B0506
-
OPC7251
|
Bacterial
Antibiotic
DNA/RNA Synthesis
Interleukin Related
|
Infection
Inflammation/Immunology
|
Nadifloxacin (OPC7251) is a broad-spectrum quinolone antibiotic. Nadifloxacin inhibits bacterial DNA gyrase and topoisomerase IV, interfering with DNA replication. It also suppresses the production of proinflammatory cytokines (such as IL-1α, IL-6, and IL-8). Nadifloxacin exhibits antibacterial activity against various pathogens, including Propionibacterium acnes and Staphylococcus aureus. Nadifloxacin also exhibits anti-inflammatory activity. Nadifloxacin can be used in the research of skin infections such as acne vulgaris, folliculitis, and impetigo .
|
-
- HY-W099331R
-
MEGX hydrochloride (Standard); Norlidocaine hydrochloride (Standard)
|
Reference Standards
Drug Metabolite
|
Metabolic Disease
Inflammation/Immunology
|
Benfuracarb (Standard) is the analytical standard of Benfuracarb. This product is intended for research and analytical applications. Benfuracarb is a broad-spectrum carbamate insecticide with crop protection activity. Benfuracarb is used to control springtails, aphids, and other pests, typically on sugar beet crops. Benfuracarb exhibits toxicity to humans and aquatic organisms. Benfuracarb exposure to zebrafish embryos resulted in a reduction in the body length of zebrafish larvae. Superoxide dismutase (SOD) activity was significantly increased after Benfuracarb treatment. Benfuracarb also interfered with the transcriptional levels of marker genes associated with early embryonic development .
|
-
- HY-B2041R
-
|
Parasite
Reference Standards
|
Infection
|
Benfuracarb (Standard) is the analytical standard of Benfuracarb. This product is intended for research and analytical applications. Benfuracarb is a broad-spectrum carbamate insecticide with crop protection activity. Benfuracarb is used to control springtails, aphids, and other pests, typically on sugar beet crops. Benfuracarb exhibits toxicity to humans and aquatic organisms. Benfuracarb exposure to zebrafish embryos resulted in a reduction in the body length of zebrafish larvae. Superoxide dismutase (SOD) activity was significantly increased after Benfuracarb treatment. Benfuracarb also interfered with the transcriptional levels of marker genes associated with early embryonic development .
|
-
- HY-W747676
-
|
Isotope-Labeled Compounds
Apoptosis
Autophagy
Necroptosis
|
Neurological Disease
|
Glyphosate- 13C is the 13C-labeled Glyphosate (HY-B0863). Glyphosate, a non-selective systemic biocide with broad-spectrum activity, is an herbicidal derivative of the amino acid glycine. Glyphosate inhibits the enzymatic activity of the 5-endopyruvylshikimate 3-phosphate synthase (EPSPS) in the shikimic acid pathway, preventing the synthesis of the aromatic amino acids tyrosine, phenylalanine, and tryptophan. Glyphosate induces oxidative stress, neuroinflammation, and mitochondrial dysfunction, processes that lead to neuronal death by autophagia, necrosis, or apoptosis, as well as the appearance of behavioral and motor disorders .
|
-
- HY-135751
-
|
Antibiotic
DNA/RNA Synthesis
|
Infection
Cancer
|
Holomycin is a secondary metabolite of the dithiolopyrrolone class. Holomycin also is a broad spectrum antibiotic. Holomycin has antitumor activity and can act in vivo on RNA synthesis .
|
-
- HY-116519
-
|
Bacterial
|
Infection
|
LY173013 is an antibacterial agent with a broad spectrum antibacterial activity. LY173013 binds to PBP 3 of E.coli and can be utilized in antibacterial research .
|
-
- HY-W013699
-
|
Antibiotic
Bacterial
Necroptosis
Apoptosis
|
Infection
|
Chlorhexidine diacetate is a orally active cationic antimicrobial agent that targets microbial cell membranes. Chlorhexidine diacetate binds to cell membrane phospholipids non-specifically, destroys membrane structure and induces leakage of cell contents. Chlorhexidine diacetate has broad-spectrum bactericidal activity against both Gram-positive and Gram-negative bacteria. Chlorhexidine diacetate can interfere with membrane permeability, cause protein precipitation and energy metabolism disorders, such as rapid inhibition of microbial growth and induction of cell death (necrosis or apoptosis) .
|
-
- HY-174414
-
|
EGFR
|
Cancer
|
EGFR/HER2-IN-18 is a stable EGFR/HER2 dual inhibitor with IC50 values of 0.09 and 0.08 μM respectively. EGFR/HER2-IN-18 exhibits broad-spectrum anti-cancer activity. EGFR/HER2-IN-18 induces MCF-7 cells apoptosis and inhibits the cell cycle. EGFR/HER2-IN-18 can be used for the study of breast cancer .
|
-
- HY-148875
-
|
Drug-Linker Conjugates for ADC
|
Cancer
|
Py-MAA-Val-Cit-PAB-MMAE is a drug-Linker conjugates for ADC, which is composed of MMAE (HY-15162) and Py-MAA-Val-Cit-PAB linked. Py-MAA-Val-Cit-PAB-MMAE can be used to synthesize Zapadcine-3a, which targeting TRAILR2. Zapadcine-3a has broad-spectrum anti-tumor activity, and can specifically kill TRAILR2-positive tumors .
|
-
- HY-16764
-
JNJ-Q2
|
Bacterial
Antibiotic
|
Infection
Inflammation/Immunology
|
Avarofloxacin (JNJ-Q2) is a broad-spectrum fluoroquinolone antibacterial agent being developed for the treatment of acute bacterial skin and skin-structure infections and community-acquired pneumonia with oral activity. Avarofloxacin (JNJ-Q2) is an aminoethylidenylpiperidine fluoroquinolone that demonstrates antibacterial effect against numerous Gram-positive bacteria with a mean 0.12 mg/L MIC90 value. Avarofloxacin (JNJ-Q2) has potential for treatment of methicillin-resistant Staphylococcus aureus (MRSA) infections .
|
-
- HY-14865B
-
PTK 0796 tosylate; Amadacycline tosylate
|
Bacterial
Antibiotic
|
Infection
|
Omadacycline (PTK 0796) tosylate, a first-in-class orally active aminomethylcycline antibacterial, is a member of the tetracycline class of antibiotics. Omadacycline tosylate acts through the inhibition of bacterial protein synthesis by binding to the 30S ribosomal subunit. Omadacycline tosylate possesses broad-spectrum antibacterial activity against aerobic and anaerobic Gram-positive and Gram-negative bacteria, as well as atypical bacteria. Omadacycline tosylate can be used for the research of acute bacterial skin and skin-structure infections, community-acquired pneumonia, and urinary tract infections .
|
-
- HY-175342
-
LOXO-338
|
Bcl-2 Family
|
Cancer
|
FCN-338 (LOXO-338) is an orally active and selective Bcl-2 inhibitor with an IC50 of 4.5 nM for Bcl-2/BAK interaction. FCN-338 potently inhibits tumor growth in follicular lymphoma (FL), acute myeloid leukemia (AML), and acute lymphoblastic leukemia (ALL) xenograft mice model without significant weight loss. FCN-338 has a broad-spectrum anti-cancer activity, such as FL, CLL/SLL, AML, and ALL .
|
-
- HY-162923
-
|
Bacterial
Antibiotic
|
Infection
|
Antibacterial agent 244 is an orally active compound with broad-spectrum antibacterial activity, primarily targeting Gram-positive bacteria, with a MIC value of 1–4 μg/mL and low hemolytic toxicity (HC50 of 111.6 μg/mL). Antibacterial agent 244 disrupts bacterial transmembrane potential, increases membrane permeability, leading to leakage of cellular contents such as DNA and proteins, ultimately causing bacterial death. Antibacterial agent 244 can be used in research related to Gram-positive bacterial infections .
|
-
- HY-14865C
-
PTK0796 hydrochloride; Amadacycline hydrochloride
|
Bacterial
Antibiotic
|
Infection
|
Omadacycline (PTK 0796) hydrochloride, a first-in-class orally active aminomethylcycline antibacterial, is a member of the tetracycline class of antibiotics. Omadacycline hydrochloride acts through the inhibition of bacterial protein synthesis by binding to the 30S ribosomal subunit. Omadacycline hydrochloride possesses broad-spectrum antibacterial activity against aerobic and anaerobic Gram-positive and Gram-negative bacteria, as well as atypical bacteria. Omadacycline hydrochloride can be used for the research of acute bacterial skin and skin-structure infections, community-acquired pneumonia, and urinary tract infections .
|
-
- HY-19754A
-
|
HDAC
Apoptosis
|
Cancer
|
CRA-026440 hydrochloride is a potent, broad-spectrum HDAC (HDAC) inhibitor. The Ki values against recombinant HDAC isoenzymes HDAC1, HDAC2, HDAC3, HDAC6, HDAC8, and HDAC10 are 4 nM, 14 nM, 11 nM, 15 nM, 7 nM, and 20 nM respectively. CRA-026440 hydrochloride shows antitumor and antiangiogenic activities . CRA-026440 (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-B1248A
-
|
Antibiotic
Bacterial
Necroptosis
Apoptosis
|
Infection
|
Chlorhexidine acetate hydrate is a orally active cationic antimicrobial agent that targets microbial cell membranes. Chlorhexidine acetate hydrate binds to cell membrane phospholipids non-specifically, destroys membrane structure and induces leakage of cell contents. Chlorhexidine acetate hydrate has broad-spectrum bactericidal activity against both Gram-positive and Gram-negative bacteria. Chlorhexidine acetate hydrate can interfere with membrane permeability, cause protein precipitation and energy metabolism disorders, such as rapid inhibition of microbial growth and induction of cell death (necrosis or apoptosis) .
|
-
- HY-A0059
-
NF 113; SAP 113; Methylmercadone
|
Bacterial
Parasite
Antibiotic
Fungal
Apoptosis
STAT
Interleukin Related
TNF Receptor
|
Infection
Inflammation/Immunology
Cancer
|
Nifuratel (NF 113) is an orally active broad-spectrum antibiotic with antiprotozoal, antibacterial, anticancer and anti-inflammatory activities, and has good inhibitory effects on Candida and Trichomonas. Nifuratel is also a STAT3 inhibitor, which significantly inhibits the growth and proliferation of human gastric cancer cells and induces apoptosis. In addition, Nifuratel also inhibits mast cell-mediated antigen hypersensitivity reactions and can be used in the study of IgE-mediated allergic diseases .
|
-
- HY-B1158
-
|
Bacterial
Mas-related G-protein-coupled Receptor (MRGPR)
Interleukin Related
|
Infection
|
Imidazolidinyl urea is a commonly used antibacterial preservative in cosmetics and pharmaceuticals that releases formaldehyde through decomposition. Imidazolidinyl urea can also be used in the preparation of multifunctional hydrogels for the care of infectious wounds. Imidazolidinyl urea has broad-spectrum antibacterial activity, which mainly inhibits the reproduction of gram-negative bacteria and gram-positive bacteria, and restricts the growth of yeast and mold to a certain extent. Imidazolidinyl urea can induce non-histaminergic allergy by MRGPRX2 activation of mast cells .
|
-
- HY-B1248
-
|
Antibiotic
Bacterial
Necroptosis
Apoptosis
|
Infection
|
Chlorhexidine is a orally active cationic antimicrobial agent that targets microbial cell membranes. Chlorhexidine binds to cell membrane phospholipids non-specifically, destroys membrane structure and induces leakage of cell contents. Chlorhexidine has broad-spectrum bactericidal activity against both Gram-positive and Gram-negative bacteria. Chlorhexidine can interfere with membrane permeability, cause protein precipitation and energy metabolism disorders, such as rapid inhibition of microbial growth and induction of cell death (necrosis or apoptosis) .
|
-
- HY-155476
-
|
Influenza Virus
|
Infection
|
Influenza virus-IN-8 (compound A4) is an inhibitor of influenza virus (Influenza Virus) that induces viral nucleoprotein (NP) aggregation and prevents its nuclear accumulation. Influenza virus-IN-8 has broad-spectrum anti-influenza activity and can inhibit the replication and transcription of influenza A virus. Influenza virus-IN-8 also inhibits Oseltamivir (HY-13317)-resistant H1N1/pdm09 strains .
|
-
- HY-14865
-
PTK 0796; Amadacycline
|
Bacterial
Antibiotic
|
Infection
|
Omadacycline (PTK 0796), a first-in-class orally active aminomethylcycline antibacterial, is a member of the tetracycline class of antibiotics. Omadacycline acts through the inhibition of bacterial protein synthesis by binding to the 30S ribosomal subunit. Omadacycline possesses broad-spectrum antibacterial activity against aerobic and anaerobic Gram-positive and Gram-negative bacteria, as well as atypical bacteria. Omadacycline can be used for the research of acute bacterial skin and skin-structure infections, community-acquired pneumonia, and urinary tract infections .
|
-
- HY-146460
-
|
Reactive Oxygen Species (ROS)
|
Infection
|
Antimicrobial agent-2 (compound V-a) is a broad-spectrum antimicrobial agent, possessing inhibitory activity against various Gram-positive and -negative bacteria. Antimicrobial agent-2 has excellent inhibitory effect on Methicillin-resistant Staphylococcus aureus (MRSA) with a MIC of 1 μg/mL. Antimicrobial agent-2 can effectively damage the membrane and lead to the leakage of protein, also can induce the generation of ROS. Antimicrobial agent-2 exhibits low toxicity, no obvious resistance and good bioavailability .
|
-
- HY-B0239
-
|
Antibiotic
Bacterial
HIF/HIF Prolyl-Hydroxylase
VEGFR
Autophagy
Apoptosis
Beclin1
JNK
Akt
MMP
|
Infection
Cancer
|
Chloramphenicol is an orally active, potent and broad-spectrum antibiotic. Chloramphenicol shows antibacterial activity. Chloramphenicol represses the oxygen-labile transcription factor and hypoxia inducible factor-1 alpha (HIF-1α) in hypoxic A549 and H1299 cells. Chloramphenicol suppresses the mRNA levels of vascular endothelial growth factor (VEGF) and glucose transporter 1, eventually decreasing VEGF release. Chloramphenicol can be used for anaerobic infections and lung cancer research .
|
-
- HY-10581R
-
AM-1155 (Standard); BMS-206584 (Standard); PD135432 (Standard)
|
Reference Standards
Bacterial
Topoisomerase
Antibiotic
|
Infection
|
Gatifloxacin (Standard) is the analytical standard of Gatifloxacin. This product is intended for research and analytical applications. Gatifloxacin (AM-1155; BMS-206584; PD135432) is a potent fluoroquinolone antibiotic with broad-spectrum antibacterial activity. Gatifloxacin inhibits bacterial type II topoisomerases (IC50=13.8 μg/ml for S. aureus topoisomerase IV) and E. coli DNA gyrase (IC50=0.109 μg/ml) . Gatifloxacin can be used to treat bacterial conjunctivitis in vivo.
|
-
- HY-B0223R
-
-
- HY-14865A
-
PTK 0796 mesylate; Amadacycline mesylate
|
Bacterial
Antibiotic
|
Infection
|
Omadacycline (PTK 0796) mesylate, a first-in-class orally active aminomethylcycline antibacterial, is a member of the tetracycline class of antibiotics. Omadacycline mesylate acts through the inhibition of bacterial protein synthesis by binding to the 30S ribosomal subunit. Omadacycline mesylate possesses broad-spectrum antibacterial activity against aerobic and anaerobic Gram-positive and Gram-negative bacteria, as well as atypical bacteria. Omadacycline mesylate can be used for the research of acute bacterial skin and skin-structure infections, community-acquired pneumonia, and urinary tract infections .
|
-
- HY-19754
-
|
HDAC
Apoptosis
|
Cardiovascular Disease
Cancer
|
CRA-026440 is a potent, broad-spectrum HDAC inhibitor. The Ki values against recombinant HDAC isoenzymes HDAC1, HDAC2, HDAC3, HDAC6, HDAC8, and HDAC10 are 4, 14, 11, 15, 7, and 20 nM respectively. CRA-026440 shows antitumor and antiangiogenic activities . CRA-026440 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-B0122S
-
-
- HY-B1145
-
|
Antibiotic
Bacterial
Necroptosis
Apoptosis
|
Infection
|
Chlorhexidine dihydrochloride is a orally active cationic antimicrobial agent that targets microbial cell membranes. Chlorhexidine dihydrochloride binds to cell membrane phospholipids non-specifically, destroys membrane structure and induces leakage of cell contents. Chlorhexidine dihydrochloride has broad-spectrum bactericidal activity against both Gram-positive and Gram-negative bacteria. Chlorhexidine dihydrochloride can interfere with membrane permeability, cause protein precipitation and energy metabolism disorders, such as rapid inhibition of microbial growth and induction of cell death (necrosis or apoptosis) .
|
-
- HY-110234R
-
McN 4853 D12 (Standard); RWJ 17021 D12 (Standard)
|
Reference Standards
iGluR
GABA Receptor
Sodium Channel
Calcium Channel
Potassium Channel
Carbonic Anhydrase
|
Neurological Disease
|
Topiramate D12 (Standard) is the analytical standard of Topiramate D12. This product is intended for research and analytical applications. Topiramate D12 (McN 4853 D12) is a deuterium labeled Topiramate. Topiramate is a broad-spectrum antiepileptic agent. Topiramate is a GluR5 receptor antagonist. Topiramate produces its antiepileptic effects through enhancement of GABAergic activity, inhibition of kainate/AMPA receptors, inhibition of voltage-sensitive sodium and calcium channels, increases in potassium conductance, and inhibition of carbonic anhydrase .
|
-
- HY-10581CR
-
AM-1155 sesquihydrate (Standard); BMS-206584 sesquihydrate (Standard); PD135432 sesquihydrate (Standard)
|
Reference Standards
Bacterial
Topoisomerase
Antibiotic
|
Infection
Inflammation/Immunology
|
Gatifloxacin (sesquihydrate) (Standard) is the analytical standard of Gatifloxacin (sesquihydrate). This product is intended for research and analytical applications. Gatifloxacin sesquihydrate (AM-1155; BMS-206584; PD135432) is a potent fluoroquinolone antibiotic with broad-spectrum antibacterial activity. Gatifloxacin sesquihydrate inhibits bacterial type II topoisomerases (IC50=13.8 μg/ml for S. aureus topoisomerase IV) and E. coli DNA gyrase (IC50 = 0.109 μg/ml) . Gatifloxacin sesquihydrate can be used to treat bacterial conjunctivitis?in vivo.
|
-
- HY-B1282A
-
|
Bacterial
Parasite
Antibiotic
|
Infection
|
Sulfaquinoxaline sodium salt is an antimicrobial for veterinary use, with activity against a broad spectrum of Gram-negative and Gram-positive bacteria. Sulfaquinoxaline is used to prevent coccidiosis and bacterial infections .
|
-
- HY-B1282
-
|
Bacterial
Parasite
Antibiotic
|
Infection
|
Sulfaquinoxaline is an antimicrobial for veterinary use, with activity against a broad spectrum of Gram-negative and Gram-positive bacteria. Sulfaquinoxaline is used to prevent coccidiosis and bacterial infections .
|
-
- HY-N14491
-
|
Antibiotic
Bacterial
|
Infection
|
Coumamidine γ2 is a kind of alkaline sugar Cinodine antibiotic, which has broad spectrum antibacterial activity and also has effect on pseudomonas aeruginosa .
|
-
- HY-B0272S2
-
Rifampin-d4; Rifamycin AMP-d4
|
Bacterial
Influenza Virus
Antibiotic
|
Infection
|
Rifampicin-d4 is the deuterium labeled Rifampicin. Rifampicin is a potent and broad spectrum antibiotic against bacterial pathogens. Rifampicin has anti-influenza virus activities.
|
-
- HY-126604
-
|
Others
|
Infection
|
Pyranonigrin A is isolated and identified from Penicillium brocae MA-231. Pyranonigrin A shows potent activity against a broad spectrum of human-, aqua-, and plant-pathogens .
|
-
- HY-N14490
-
|
Antibiotic
Bacterial
|
Infection
|
Coumamidine γ1 is a kind of alkaline sugar Cinodine antibiotic, which has broad spectrum antibacterial activity and also has effect on pseudomonas aeruginosa .
|
-
- HY-158761
-
PAPB
|
Bacterial
|
Infection
|
Polyaminopropyl biguanide (PAPB), a propyl analogue of polyhexamethylene biguanide, is a broad spectrum, fast acting bactericide with antibacterial activity. Polyaminopropyl biguanide can be used as a preservative in cosmetic products .
|
-
- HY-B1802B
-
A-61827 hydrochloride
|
Antibiotic
Bacterial
|
Infection
|
Tosufloxacin (A-61827) hydrochloride is an orally active fluoroquinolone antibiotic. Tosufloxacin hydrochloride shows a broad spectrum of antibacterial activity against gram-positive and gram-negative bacteria .
|
-
- HY-B1802C
-
A-61827 tosylate
|
Antibiotic
Bacterial
|
Infection
|
Tosufloxacin (A-61827) tosylate is an orally active fluoroquinolone antibiotic. Tosufloxacin tosylate shows a broad spectrum of antibacterial activity against gram-positive and gram-negative bacteria .
|
-
- HY-P3459
-
|
Bacterial
|
Infection
|
Tet-213 is a antimicrobial peptide. Tet-213 has broad spectrum antibacterial activity. Tet-213 can promote infected wound repair .
|
-
- HY-B1802A
-
A-61827 tosylate hydrate; T-3262
|
Bacterial
Antibiotic
|
Infection
|
Tosufloxacin tosylate hydrate (A-61827) is an orally active fluoroquinolone antibiotic. Tosufloxacin shows a broad spectrum of antibacterial activity against gram-positive and gram-negative bacteria .
|
-
- HY-102087
-
JPM-OEt
3 Publications Verification
|
Cathepsin
|
Cancer
|
JPM-OEt is a broad spectrum cysteine cathepsin inhibitor. JPM-OEt binds covalently in the active site, and irreversibly inhibits the cysteine cathepsin family. Antitumor activity .
|
-
- HY-W799435
-
A-61827 hydrate
|
Antibiotic
Bacterial
|
Infection
|
Tosufloxacin (A-61827) tosylate is an orally active fluoroquinolone antibiotic. Tosufloxacin tosylate shows a broad spectrum of antibacterial activity against gram-positive and gram-negative bacteria .
|
-
- HY-B0210AR
-
CP 52640-2 (Standard)
|
Reference Standards
Bacterial
Antibiotic
|
Infection
|
Cefoperazone (sodium salt) (Standard) is the analytical standard of Cefoperazone (sodium salt). This product is intended for research and analytical applications. Cefoperazone sodium salt (CP 52640-2), a semisynthetic cephalosporin, has a broad spectrum of antibacterial activity .
|
-
- HY-B1802
-
A-61827
|
Antibiotic
Bacterial
|
Infection
|
Tosufloxacin (A-61827) is an orally active fluoroquinolone antibiotic. Tosufloxacin shows a broad spectrum of antibacterial activity against gram-positive and gram-negative bacteria .
|
-
- HY-A0269S
-
-
- HY-B0434
-
Ribasphere
|
HCV
RSV
Orthopoxvirus
Antibiotic
|
Infection
Cancer
|
Ribavirin (ICN-1229) is an antiviral agent against a broad spectrum of viruses including HCV, HIVl, and RSV. Ribavirin also has anti-orthopoxvirus and anti-variola activities.
|
-
- HY-170799
-
|
DNA/RNA Synthesis
SARS-CoV
Arenavirus
|
Infection
|
HNC-1664 is the orally active inhibitor for RNA-dependent RNA polymerase (RdRP). HNC-1664 exhibits broad-spectrum antiviral activity against coronavirus (SARS-CoV-2 wildtype and its mutants XBB.1.18, HK.3.1, BF.7.14, BA.1HCoV-229E, HCoV-OC43) and arenavirus. HNC-1664 exhibits anti-infectious activity in SARS-CoV-2 Delta infected mouse models .
|
-
- HY-172264
-
|
Antibiotic
Bacterial
DNA/RNA Synthesis
|
Infection
|
XT17 is an anthrone compound with broad-spectrum antibacterial activity. It exerts its antibacterial effect by disrupting the cell wall and inhibiting DNA synthesis. XT17 exhibits weak hemolytic activity, low cytotoxicity against mammalian cell lines, and a low frequency of drug resistance. Meanwhile, XT17 shows in vivo efficacy in a mouse corneal infection model induced by Staphylococcus aureus or Pseudomonas aeruginosa. Further docking studies have confirmed that XT17 can form a stable complex with bacterial gyrase. XT17 can be used in the research of the anti - infection field .
|
-
- HY-A0170R
-
|
Reference Standards
Bacterial
Topoisomerase
Antibiotic
|
Infection
|
Trovafloxacin (Standard) is the analytical standard of Trovafloxacin. This product is intended for research and analytical applications. Trovafloxacin is a broad-spectrum quinolone antibiotic with potent activity against Gram-positive, Gram-negative and anaerobic organisms. Trovafloxacin blocks the DNA gyrase and topoisomerase IV activity. Trovafloxacin is also a potent, selective and orally active pannexin 1 channel (PANX1) inhibitor with an IC50 of 4 μM for PANX1 inward current. Trovafloxacin does not inhibit connexin 43 gap junction or PANX2. Trovafloxacin leads to dysregulated fragmentation of apoptotic cells by inhibiting PANX1 .
|
-
- HY-B1599R
-
|
Reference Standards
Bacterial
Antibiotic
|
Infection
|
Chloramphenicol palmitate (Standard) is the analytical standard of Chloramphenicol palmitate. This product is intended for research and analytical applications. Chloramphenicol palmitate is an orally active broad spectrum antibiotic and has a broad spectrum of activity against gram positive and gram negative bacteria. Chloramphenicol palmitate inhibits bacterial protein synthesis by blocking the peptidyl transferase step. Chloramphenicol palmitate can be used as bacterial selection agent in transformed cells containing chloramphenicol resistance genes .
|
-
- HY-17460A
-
BMS284756 Mesylate hydrate
|
Bacterial
Topoisomerase
DNA/RNA Synthesis
Antibiotic
|
Infection
|
Garenoxacin (BMS284756) Mesylate hydrate is an orally active quinolone antibiotic and has a broad spectrum of activity against a wide array of gram-positive and gram-negative bacteria, anaerobes, and fastidious organisms .
|
-
- HY-B0272S
-
Rifampin-d3; Rifamycin AMP-d3
|
Bacterial
Influenza Virus
Antibiotic
|
Infection
|
Rifampicin-d3 is the deuterium labeled Rifampicin. Rifampicin is a potent and broad spectrum antibiotic against bacterial pathogens. Rifampicin has anti-influenza virus activities .
|
-
- HY-B0467
-
Amoxycillin sodium
|
Bacterial
Antibiotic
|
Infection
Cancer
|
Amoxicillin (Amoxycillin) sodium is an antibiotic with good oral absorption and broad spectrum antimicrobial activity. Amoxicillin sodium inhibits the biosynthesis of polypeptides in the cell wall, thereby inhibiting cell growth .
|
-
- HY-17460
-
-
- HY-16394
-
CGC-11047 tetrahydrochloride
|
Drug Derivative
|
Cancer
|
PG-11047 (CGC-11047), a polyamine analogue, is a nonfunctional competitor of the natural polyamine spermine. PG-11047 has broad spectrum anticancer activities .
|
-
- HY-B0467A
-
Amoxycillin
|
Bacterial
Antibiotic
|
Infection
Cancer
|
Amoxicillin (Amoxycillin) is an antibiotic with good oral absorption and broad spectrum antimicrobial activity. Amoxicillin inhibits the biosynthesis of polypeptides in the cell wall, thereby inhibiting cell growth .
|
-
- HY-P5601
-
|
Bacterial
Fungal
|
Infection
|
Thanatin is an inducible cationic antimicrobial peptide. Thanatin is a pathogen-inducible single-disulfide-bond-containing β-hairpin AMP. Thanatin displays broad-spectrum activity against both Gram-negative and Gram-positive bacteria as well as against various species of fungi with MICs of 0.3-40 µM, 0.6-40 µM and 0.6-20 µM, respectively. Thanatin has the property of competitive replacement of divalent cations from bacterial outer membrane (OM), leading to OM disruption .
|
-
- HY-N0168
-
|
p38 MAPK
Autophagy
Apoptosis
Reactive Oxygen Species (ROS)
NF-κB
Bcl-2 Family
|
Neurological Disease
Cancer
|
Hesperetin is a natural flavanone that can be found in citrus, and acts as a potent and orally active broad-spectrum inhibitor against human UGT activity. Hesperetin induces apoptosis via p38 MAPK activation. Hesperetin displays a range of bioactivities including antioxidant, anti-inflammatory, and anti-cancer. Hesperetin is found to induce cell-cycle arrest at G2/M phase. Hesperetin can reduce Bcl-2 and enhance BaxM. Hesperetin induces apoptosis through inhibiting NF-κB receptor .
|
-
- HY-B1190S
-
BL-S 578-d4 hydrate
|
Isotope-Labeled Compounds
Bacterial
Antibiotic
EAAT
|
Infection
Neurological Disease
|
Cefadroxil-d4 (hydrate) is the deuterium labeled Cefadroxil hydrate (HY-B1190A). Cefadroxil hydrate is an orally active broad-spectrum cephalosporin antibiotic. Cefadroxil hydrate inhibits bacterial cell wall synthesis and enhances the expression of glutamate transporter-1. Cefadroxil hydrate is dependent on the intestinal peptide transporter PepT1 for small intestinal absorption. Cefadroxil hydrate has inhibitory and bactericidal activity against a variety of Gram-positive and Gram-negative bacteria and has analgesic effects on neuropathic pain .
|
-
- HY-B1885
-
|
Insecticide
Parasite
Cholinesterase (ChE)
AMPK
PI3K
Akt
Apoptosis
SOD
|
Infection
|
Fenitrothion is a broad-spectrum and orally active insecticide/acaricide. Fenitrothion inhibits cholinesterase, AMPKα and IRS1/PI3K/AKT. Fenitrothion causes Apoptosis, reduces SOD activity. Fenitrothion shows insecticidal effect against Rhyzopertha dominica and Tribolium castaneum adults. Fenitrothion is widely used in cotton crops, vegetable crops, fruit crops and field crops, especially rice. Fenitrothion can be used for brain and spleen toxicology studies .
|
-
- HY-W740028
-
ME 1206-d3
|
Isotope-Labeled Compounds
Bacterial
Beta-lactamase
|
Infection
Inflammation/Immunology
|
Cefditoren-d3 (sodium) (ME 1206-d3) is deuterium labeled Cefditoren (sodium). Cefditoren sodium (ME 1206) is a broad-spectrum, third-generation, oral cephalosporin antibacterial with enhanced stability against many common β lactamases. Cefditoren sodium has activity against Gram-negative organisms and Gram-positive organisms. Cefditoren sodium can be used in the research of infection diseases such as acute exacerbations of chronic bronchitis, community-acquired pneumonia (CAP), streptococcal pharyngitis/tonsillitis, or uncomplicated skin and skin structure infections .
|
-
- HY-155186
-
|
SARS-CoV
|
Infection
|
SARS-CoV-2 3CLpro-IN-19 (Compound C5a) is a non-covalent, non-peptide SARS-CoV-2 3CLpro inhibitor (IC50s: 0.7 μM). SARS-CoV-2 3CLpro-IN-19 has broad-spectrum activity against Omicron subvariants (BA.5, BQ.1.1, and XBB.1.5) infection in human cells, with EC50 values between 30-69 nM .
|
-
- HY-17452AR
-
Cefditoren pivoxyl (Standard); Cefditoren pivaloyloxymethyl ester (Standard); ME 1207 (Standard)
|
Beta-lactamase
Reference Standards
Bacterial
Antibiotic
|
Infection
Inflammation/Immunology
|
Cefditoren Pivoxil (Standard) is the analytical standard of Cefditoren Pivoxil. This product is intended for research and analytical applications. Cefditoren Pivoxil (ME 1207) is a broad-spectrum, third-generation, oral cephalosporin antibacterial with enhanced stability against many common β lactamases. Cefditoren Pivoxil has activity against Gram-negative organisms and Gram-positive organisms. Cefditoren Pivoxil can be used in the research of infection diseases such as acute exacerbations of chronic bronchitis, community-acquired pneumonia (CAP), streptococcal pharyngitis/tonsillitis, or uncomplicated skin and skin structure infections .
|
-
- HY-148852
-
|
HSV
|
Infection
|
PNU-183792, a 4-oxo-dihydroquinoline, is an orally active HSV polymerases inhibitor. PNU-183792 shows a broad-spectrum antiviral activity, with IC50 values of 0.69 μM, 0.37 μM and 0.58 μM for human cytomegalovirus (HCM), varicella zoster virus and HSV polymerases, respectively. PNU-183792 is inactive against human α, γ and δ polymerases. PNU-183792 also inhibits simian varicella virus (SVV), murine cytomegalovirus (MCMV) and rat cytomegalovirus (RCMV) .
|
-
- HY-B0724A
-
T-3762; Pazufloxacin methanesulfonate; Pazufloxacin mesilate
|
Bacterial
DNA/RNA Synthesis
|
Infection
|
Pazufloxacin mesylate is an orally active fluoroquinolone antimicrobial agent. Pazufloxacin mesylate inhibits DNA gyrase with IC50 values of 0.88 μg/mL (E. coli) and 1.9 μg/mL (P. aeruginosa). Pazufloxacin mesylate exhibits broad-spectrum antimicrobial activity, with MIC90 values ranging from 0.025 to 100 μg/mL against Gram-positive and Gram-negative bacteria, non-fermenting bacteria, Legionella spp., and anaerobic bacteria. Pazufloxacin mesylate is indicated for research on systemic infections, lung infections, urinary tract infections, and Legionella pneumonia .
|
-
- HY-B0724B
-
T3761
|
Bacterial
DNA/RNA Synthesis
|
Infection
|
Pazufloxacin is an orally active fluoroquinolone antimicrobial agent. Pazufloxacin inhibits DNA gyrase with IC50 values of 0.88 μg/mL (E. coli) and 1.9 μg/mL (P. aeruginosa). Pazufloxacin exhibits broad-spectrum antimicrobial activity, with MIC90 values ranging from 0.025 to 100 μg/mL against Gram-positive and Gram-negative bacteria, non-fermenting bacteria, Legionella spp., and anaerobic bacteria. Pazufloxacin is indicated for research on systemic infections, lung infections, urinary tract infections, and Legionella pneumonia .
|
-
- HY-168258
-
|
Bacterial
|
Infection
|
Antibiofilm agent-13 (compound 14b) is a potent antibacterial agent that displays a broad-spectrum antimicrobial activity. Antibiofilm agent-13 could disintegrate the integrity of bacterial cell membranes by destroying transmembrane potential and enhancing membrane permeability, and causing the generation of intracellular ROS and the leakage of DNA and proteins, ultimately leading to bacterial death. Antibiofilm agent-13 inhibits both Gram-positive bacteria (MIC of 0.5-1 μg/mL) and Gram-negative bacteria (MIC of 1-32 μg/mL) .
|
-
- HY-B1256A
-
Kefurox
|
Beta-lactamase
Bacterial
Antibiotic
|
Infection
Cancer
|
Cefuroxime is an orally active second-generation cephalosporin antibiotic with increased stability to β-lactamase. Cefuroxime has a broad spectrum activity against Gram-positive and Gram-negative bacteria .
|
-
- HY-N6705
-
|
Bacterial
Antibiotic
|
Infection
|
Tropodithietic acid is a sulfur-containing antibiotic produced by the marine bacterium Phaeobacter inhibens. Tropodithietic acid exhibits a strong antibiotic activity against a broad spectrum of bacteria including alpha- and gammaproteobacteria, flavobacteria and actinobacteria .
|
-
- HY-169129
-
ILX-295501
|
Drug Derivative
|
Cancer
|
LY-295501 is a sulfonylurea compound that has demonstrated in-vivo antitumor activity against a broad spectrum of solid tumors. LY-295501 can be utilized in cancer research .
|
-
- HY-B1256
-
|
Beta-lactamase
Bacterial
Antibiotic
|
Infection
Cancer
|
Cefuroxime sodium is an orally active second-generation cephalosporin antibiotic with increased stability to β-lactamase. Cefuroxime sodium has a broad spectrum activity against Gram-positive and Gram-negative bacteria .
|
-
- HY-B0529A
-
Sodium azlocillin
|
Bacterial
Parasite
Antibiotic
|
Infection
|
Azlocillin sodium salt (Sodium azlocillin), a semisynthetic penicillin, is a broad spectrum β-lactam antibiotic. Azlocillin sodium salt shows antipseudomonal activity, and also potent against the malarial parasite Plasmodium falciparum .
|
-
- HY-108402
-
|
Penicillin-binding protein (PBP)
Bacterial
Antibiotic
|
Infection
|
Cefodizime is a third generation cephalosporin antibiotic with a broad spectrum of antibacterial activity. Cefodizime has no renal toxic effect, good tolerance and immune regulation activity, and has the potential for severe infections of the respiratory and urinary tracts .
|
-
- HY-122448A
-
|
Bacterial
Fungal
|
Infection
|
(Rac)-Sativan is an isoflavanoid with a broad spectrum of antimicrobial activity against bacteria and phytopathogenic fungi. (Rac)-Sativan exhibits antituberculosis activity against Mycobacterium tuberculosis H37Rv, with MIC values of 50 µg/mL .
|
-
- HY-N0275R
-
|
Topoisomerase
|
Cancer
|
(±)-10-Hydroxycamptothecin (Standard) is the analytical standard of (±)-10-Hydroxycamptothecin. This product is intended for research and analytical applications. (±)-10-Hydroxycamptothecin is an indole alkaloid that inhibits the activity of topoisomerase I and has a broad spectrum of anticancer activity.
|
-
- HY-B0863S5
-
|
Isotope-Labeled Compounds
Apoptosis
Autophagy
Necroptosis
|
Neurological Disease
|
Glyphosate- 13C, 15N-1 is the 13C- and 15N-labeled Glyphosate (HY-B0863). Glyphosate, a non-selective systemic biocide with broad-spectrum activity, is an herbicidal derivative of the amino acid glycine. Glyphosate inhibits the enzymatic activity of the 5-endopyruvylshikimate 3-phosphate synthase (EPSPS) in the shikimic acid pathway, preventing the synthesis of the aromatic amino acids tyrosine, phenylalanine, and tryptophan. Glyphosate induces oxidative stress, neuroinflammation, and mitochondrial dysfunction, processes that lead to neuronal death by autophagia, necrosis, or apoptosis, as well as the appearance of behavioral and motor disorders .
|
-
- HY-117736
-
|
Penicillin-binding protein (PBP)
Bacterial
|
Infection
Inflammation/Immunology
|
Ro 09-1428 is a broad-spectrum parenteral cephalosporin. Ro 09-1428 has potent antibacterial activities against Pseudomonas aeruginosa and Acinetobacter caloaceticus, with MIC90s of 0.39 and 6.25 μg/mL, respectively, better than Ceftazidime (HY-B0593). Additionally, Ro 09-1428 shows high activity against Escherichia coli, Kkbsielia pneumoniae, Proteus mirabilis, P. aeruginosa, staphylococci, and more. Ro 09-1428 preferentially attacks PBP 3 for target in E. coli and P. aeruginosa, which is promising for research of septicemias and serious P. aeruginosa infections .
|
-
- HY-119725
-
|
Insecticide
|
Infection
|
Tetradifon is a broad-spectrum organochlorine insecticide and an inhibitor of the mitochondrial oligomycin sensitivity conferring protein (OSCP), which can be used to control a variety of mites. Tetradifon inhibits energy-related activities such as ADP-stimulated respiration, DNP and Mg 2+-stimulated ATPase, with an IC50 of 4.5-27 nmoL/mg mitochondrial protein. Tetradifon exerts oligomycin-like activity by inhibiting the oxidative phosphorylation process, inducing oxidative stress and interfering with bone metabolism. Tetradifon is currently mainly used in the research of mitochondrial function regulation, bone remodeling mechanism and nephrotoxicity of environmental pollutants .
|
-
- HY-134809A
-
CADA hydrochloride
|
HIV
|
Infection
|
Cyclotriazadisulfonamide (CADA) hydrochloride is a specific CD4-targeted HIV entry inhibitor with activity against HIV-1 replication. Cyclotriazadisulfonamide hydrochloride can specifically downregulate the expression of CD4 receptors on the cell surface, effectively inhibiting HIV transmission. Cyclotriazadisulfonamide hydrochloride can inhibit HIV-1(NL4.3) and SIV(mac251), and has a synergistic effect when used in combination with cellulose acetate (CAP). Cyclotriazadisulfonamide hydrochloride can also be used as a microbial gel formulation to maintain CD4 downregulation and antiviral activity, and is a broad-spectrum anti-HIV agent.
|
-
- HY-174353S
-
|
Cytochrome P450
Fungal
Isotope-Labeled Compounds
|
Infection
|
CYP51-IN-23-d3 is a potent and broad-spectrum CYP51 inhibitor with a MIC80 of 1 μg/mL against Aspergillus fumigatum . CYP51-IN-23-d3 can prevent fungal phase transformation and biofilm formation. CYP51-IN-23-d3 exhibits anti-drug resistance activity and fungal activity, and shows excellent safety for cells and significant pharmacological activity in mice. CYP51-IN-23-d3 can be used for the study of invasive fungal infections (IFIs) .
|
-
- HY-123047S
-
-
- HY-B0272S1
-
Rifampin-d8; Rifamycin AMP-d8
|
Bacterial
Influenza Virus
Antibiotic
|
Infection
|
Rifampicin-d8 (Rifampin-d8) is the deuterium labeled Rifampicin. Rifampicin is a potent and broad spectrum antibiotic against bacterial pathogens. Rifampicin has anti-influenza virus activities.
|
-
- HY-A0269R
-
Amdinocillin (Standard); FL 1060 (Standard)
|
Reference Standards
Bacterial
Antibiotic
|
Infection
|
Mecillinam (Standard) is the analytical standard of Mecillinam. This product is intended for research and analytical applications. Mecillinam (Amdinocillin), the β-lactam antibiotic, has a broad spectrum of activity against gram-negative organisms .
|
-
- HY-B0467C
-
Amoxycillin arginine
|
Antibiotic
Bacterial
|
Infection
Cancer
|
Amoxicillin (Amoxycillin) arginine is an antibiotic with good oral absorption and broad spectrum antimicrobial activity. Amoxicillin arginine inhibits the biosynthesis of polypeptides in the cell wall, thereby inhibiting cell growth .
|
-
- HY-B0467B
-
Amoxycillin trihydrate
|
Bacterial
Antibiotic
|
Infection
Cancer
|
Amoxicillin (Amoxycillin) trihydrateis an antibiotic with good oral absorption and broad spectrum antimicrobial activity. Amoxicillin trihydrateis inhibits the biosynthesis of polypeptides in the cell wall, thereby inhibiting cell growth .
|
-
- HY-P3459A
-
|
Bacterial
|
Infection
|
Tet-213 TFA is a antimicrobial peptide. Tet-213 TFA has broad spectrum antibacterial activity. Tet-213 TFA can promote infected wound repair .
|
-
- HY-108402A
-
|
Penicillin-binding protein (PBP)
Bacterial
Antibiotic
|
Infection
|
Cefodizime sodium is a third generation cephalosporin antibiotic with a broad spectrum of antibacterial activity. Cefodizime sodium has no renal toxic effect, good tolerance and immune regulation activity, and can be used for the research of severe infections of the respiratory and urinary tracts .
|
-
- HY-108325
-
-
- HY-B0272R
-
Rifampin (Standard); Rifamycin AMP (Standard)
|
Reference Standards
Bacterial
Influenza Virus
Antibiotic
Orthopoxvirus
|
Infection
Cancer
|
Rifampicin (Standard) is the analytical standard of Rifampicin. This product is intended for research and analytical applications. Rifampicin is a potent and broad spectrum antibiotic against bacterial pathogens. Rifampicin has anti-influenza virus activities. Rifampicin shows anti-orthopoxvirus activity.
|
-
- HY-B1190R
-
BL-S 578 (Standard)
|
Reference Standards
Bacterial
Antibiotic
EAAT
|
Infection
Neurological Disease
|
Cefadroxil (Standard) is the analytical standard of Cefadroxil (HY-B1190). This product is intended for research and analytical applications. Cefadroxil is an orally active broad-spectrum cephalosporin antibiotic. Cefadroxil inhibits bacterial cell wall synthesis and enhances the expression of glutamate transporter-1. Cefadroxil is dependent on the intestinal peptide transporter PepT1 for small intestinal absorption. Cefadroxil has inhibitory and bactericidal activity against a variety of Gram-positive and Gram-negative bacteria and has analgesic effects on neuropathic pain .
|
-
- HY-B0239R
-
|
Reference Standards
Antibiotic
Bacterial
HIF/HIF Prolyl-Hydroxylase
VEGFR
Autophagy
Apoptosis
Beclin1
JNK
Akt
MMP
|
Infection
Cancer
|
Chloramphenicol (Standard) is the analytical standard of Chloramphenicol. This product is intended for research and analytical applications. Chloramphenicol is an orally active, potent and broad-spectrum antibiotic. Chloramphenicol shows antibacterial activity. Chloramphenicol represses the oxygen-labile transcription factor and hypoxia inducible factor-1 alpha (HIF-1α) in hypoxic A549 and H1299 cells. Chloramphenicol suppresses the mRNA levels of vascular endothelial growth factor (VEGF) and glucose transporter 1, eventually decreasing VEGF release. Chloramphenicol can be used for anaerobic infections and lung cancer research .
|
-
- HY-B1145S
-
|
Isotope-Labeled Compounds
Antibiotic
Bacterial
Necroptosis
Apoptosis
|
Infection
|
Chlorhexidine-d8 (dihydrochloride) is the deuterium labeled Chlorhexidine dihydrochloride (HY-B1145). Chlorhexidine dihydrochloride is a orally active cationic antimicrobial agent that targets microbial cell membranes. Chlorhexidine dihydrochloride binds to cell membrane phospholipids non-specifically, destroys membrane structure and induces leakage of cell contents. Chlorhexidine dihydrochloride has broad-spectrum bactericidal activity against both Gram-positive and Gram-negative bacteria. Chlorhexidine dihydrochloride can interfere with membrane permeability, cause protein precipitation and energy metabolism disorders, such as rapid inhibition of microbial growth and induction of cell death (necrosis or apoptosis) .
|
-
- HY-17452AS
-
Cefditoren pivoxyl-d3; Cefditoren pivaloyloxymethyl ester-d3; ME 1207-d3
|
Isotope-Labeled Compounds
Antibiotic
Beta-lactamase
Bacterial
|
Infection
Inflammation/Immunology
|
Cefditoren Pivoxil-d3 (Cefditoren pivoxyl-d3) is deuterium labeled Cefditoren Pivoxil. Cefditoren Pivoxil (ME 1207) is a broad-spectrum, third-generation, oral cephalosporin antibacterial with enhanced stability against many common β lactamases. Cefditoren Pivoxil has activity against Gram-negative organisms and Gram-positive organisms. Cefditoren Pivoxil can be used in the research of infection diseases such as acute exacerbations of chronic bronchitis, community-acquired pneumonia (CAP), streptococcal pharyngitis/tonsillitis, or uncomplicated skin and skin structure infections .
|
-
- HY-N0168A
-
|
p38 MAPK
Apoptosis
Autophagy
Reactive Oxygen Species (ROS)
NF-κB
Bcl-2 Family
|
Neurological Disease
Cancer
|
(Rac)-Hesperetin is the racemate of Hesperetin. Hesperetin is a natural flavanone that can be found in citrus, and acts as a potent and orally active broad-spectrum inhibitor against human UGT activity. Hesperetin induces apoptosis via p38 MAPK activation. Hesperetin displays a range of bioactivities including antioxidant, anti-inflammatory, and anti-cancer. Hesperetin is found to induce cell-cycle arrest at G2/M phase. Hesperetin can reduce Bcl-2 and enhance BaxM. Hesperetin induces apoptosis through inhibiting NF-κB receptor .
|
-
- HY-175165
-
|
Enterovirus
|
Infection
|
Jun6504 is an enterovirus 2C inhibitor. Jun6504 shows potent and broad-spectrum antiviral activity against multiple strains of EV-D68 (EC50 = 250 nM), EV-A71 (EC50 = 502.4 nM), and CVB3 (EC50 = 1049 nM). Jun6504 improves paralysis score and weight gain in a neonatal mouse model of EV-D68 infection. Jun6504 reduces viral titers in the spinal cord and the infected quadriceps muscle. Jun6504 can be used for EV-D68 antiviral research .
|
-
- HY-144122
-
|
HIV
|
Infection
|
HIV-1 inhibitor-15 (compound 9d) is a highly potent and broad-spectrum HIV-1 inhibitor. HIV-1 inhibitor-15 has inhibitory activity against HIV-1 WT, L100I, K103N, Y181C, E138K with EC50s of 1.7 nM, 4 nM, 2 nM, 6 nM and 9 nM, respectively. HIV-1 inhibitor-15 has good solubility, safety profiles and favorable oral bioavailability .
|
-
- HY-B0223S4
-
SKF-62979-d3-1
|
Reactive Oxygen Species (ROS)
|
Cancer
|
Albendazole-d3-1 (SKF-62979-d3-1) is the deuterium labeled Albendazole (HY-B0223). Albendazole (SKF-62979) is an orally active and broad-spectrum parasiticide with high effectiveness and low host toxicity, is used for the research of gastrointestinal parasites in humans and animals. Albendazole induces apoptosis and autophagy in cancer cells. Albendazole also inhibits tubulin polymerization and HIF-1α, VEGF expression, has antioxidant activity, and inhibits the glycolytic process in cancer cells .
|
-
- HY-P5601A
-
|
Bacterial
Fungal
|
Infection
|
Thanatin TFA is an inducible cationic antimicrobial peptide. Thanatin TFA s a pathogen-inducible single-disulfide-bond-containing β-hairpin AMP. Thanatin TFA displays broad-spectrum activity against both Gram-negative and Gram-positive bacteria as well as against various species of fungi with MICs of 0.3-40 µM, 0.6-40 µM and 0.6-20 µM, respectively. Thanatin TFA has the property of competitive replacement of divalent cations from bacterial outer membrane (OM), leading to OM disruption .
|
-
- HY-158028
-
|
Influenza Virus
|
Infection
|
PAN endonuclease-IN-2 (compound T-31) is a PAN endonuclease inhibitor (IC50: 0.15 μM) and antiviral agent with broad-spectrum anti- Influenza activity. PAN is the N-terminal PA subunit of the polymerase-RNA complex and the dependent endonuclease (CEN) active site. PAN initiates RNA replication by promoting cleavage of the RNA strand and allowing the polymerase to begin synthesizing new RNA molecules. PAN endonuclease-IN-2 targets both the influenza HA and RdRp complexes, thereby interfering with viral entry into host cells and viral replication .
|
-
- HY-B0239S2
-
|
JNK
Apoptosis
VEGFR
MMP
Bacterial
Akt
Autophagy
HIF/HIF Prolyl-Hydroxylase
Antibiotic
Beclin1
|
Cancer
|
Threo-Chloramphenicol-d6 is the deuterium labeled Chloramphenicol . Chloramphenicol is an orally active, potent and broad-spectrum antibiotic. Chloramphenicol shows antibacterial activity. Chloramphenicol represses the oxygen-labile transcription factor and hypoxia inducible factor-1 alpha (HIF-1α) in hypoxic A549 and H1299 cells. Chloramphenicol suppresses the mRNA levels of vascular endothelial growth factor (VEGF) and glucose transporter 1, eventually decreasing VEGF release. Chloramphenicol can be used for anaerobic infections and lung cancer research .
|
-
- HY-119257
-
|
Farnesyl Transferase
Apoptosis
|
Cancer
|
ABT-100 is a potent, highly selective and orally active farnesyltransferase inhibitor. ABT-100 inhibits cell proliferation (IC50s of 2.2 nM, 3.8 nM, 5.9 nM, 6.9 nM, 9.2 nM, 70 nM and 818 nM for EJ-1, DLD-1, MDA-MB-231, HCT-116, MiaPaCa-2, PC-3, and DU-145 cells, respectively), increases apoptosis and decreases angiogenesis. ABT-100 possesses broad-spectrum antitumor activity .
|
-
- HY-B1537
-
2',3',5'-Tri-O-acetyl-6-azauridine
|
Virus Protease
Influenza Virus
|
Infection
Inflammation/Immunology
|
Azaribine (2',3',5'-Tri-O-acetyl-6-azauridine) is a potent orotidine monophosphate decarboxylase (OMPD) inhibitor. Azaribine is an antiviral inhibitor of several RNA viruses and inhibits viral genome replication and gene transcription. Azaribine shows broad-spectrum antiviral activity (EC50=3.80 nM-1.73 μM against influenza A and B viruses; EC50=1.62 μM against ZIKV Paraiba). Azaribine, a triacetate salt of Azauridine, has the potential for psoriasis research .
|
-
- HY-117108
-
|
Antibiotic
Bacterial
|
Infection
|
Nocardicin A is a beta-lactam antibiotic with selective antibacterial activity. Nocardicin A has moderate antibacterial activity against a broad spectrum of Gram-negative bacteria including Proteus and Pseudomonas; it has no inhibitory effect on Staphylococcus, Mycobacterium, fungi, and yeast .
|
-
- HY-B0771
-
SCE-2787
|
Bacterial
Antibiotic
|
Infection
|
Cefozopran (SCE-2787) is a semi-synthetic, parenteral, fourth-generation cephalosporin. Cefozopran, an antibiotic, has a broad spectrum of antibacterial activity, inhibiting most of the gram-negative and gram-positive organisms .
|
-
- HY-100589
-
Sch 21420 sulfate
|
Bacterial
Antibiotic
|
Infection
|
Isepamicin sulfate (Sch 21420 sulfate) is a broad spectrum aminoglycoside antibiotic. Isepamicin sulfate exhibits considerable antimicrobial activity against Gram-negative non-fermenters in a region with high antimicrobial resistance .
|
-
- HY-107330
-
|
Antibiotic
|
Others
|
(6R,7S)-Cefminox sodium heptahydrate is an isomer of Cefminox sodium heptahydrate. Cefminox sodium heptahydrate is a β-lactam cephalosporin antibiotic, which exhibits a broad spectrum of antibacterial activity .
|
-
- HY-123162A
-
Fortimicin A disulfate; KW-1070 disulfate
|
Antibiotic
Bacterial
|
Infection
|
Astromicin disulfate is a water-soluble aminoglycoside antibiotic that can be isolated from the genus Micromonospora. Astromicin disulfate exhibits broad spectrum antibacterial activity against gram positive and negative bacteria .
|
-
- HY-13986A
-
(R)-VX-497; (R)-MMPD
|
IMPDH
|
Infection
|
(R)-Merimepodib is the isomer of Merimepodib (HY-13986), and can be used as an experimental control. Merimepodib (VX-497) is a noncompetitive and oral inhibitor of inosine monophosphate dehydrogenase (IMPDH) with broad spectrum antiviral activities.
|
-
- HY-N1950R
-
Dinatin (Standard)
|
Reference Standards
Pim
|
Cancer
|
Hispidulin (Standard) is the analytical standard of Hispidulin. This product is intended for research and analytical applications. Hispidulin is a natural flavone with a broad spectrum of biological activities. Hispidulin is a Pim-1 inhibitor with an IC50 of 2.71 μM.
|
-
- HY-B0226
-
Nitrofural
|
Bacterial
Antibiotic
|
Infection
|
Nitrofurazone (Nitrofural) is a broad spectrum antibiotic that has oral activity. Nitrofurazone is a nitro-aromatic drug. Nitrofurazone is active against both Gram-positive and Gram-negative bacteria .
|
-
- HY-B0771A
-
SCE-2787 hydrochloride
|
Bacterial
Antibiotic
|
Infection
|
Cefozopran (SCE-2787) hydrochloride is a semi-synthetic, parenteral, fourth-generation cephalosporin. Cefozopran hydrochloride, an antibiotic, has a broad spectrum of antibacterial activity, inhibiting most of the gram-negative and gram-positive organisms .
|
-
- HY-P3914
-
Oct-CA(1-7)M(2-9)
|
Bacterial
|
Infection
|
Cecropin A (1-7)-Melittin A (2-9) is an antimicrobial peptide with antimicrobial activity against a broad spectrum of Gram-positive and Gram-negative aerobic bacteria, as well as antimalarial activity, without the adverse hemolytic properties of bee venom peptides .
|
-
- HY-155007
-
|
Bacterial
|
Infection
|
DNA gyrase B-IN-2 (Compound E) is a 2-aminobenzothiazole-based DNA gyrase B inhibitor with promising activity against ESKAPE bacterial pathogens. DNA gyrase B-IN-2 showed low nanomolar inhibition of DNA gyrase (IC50 < 10 nM) and broad-spectrum antibacterial activity against pathogens belonging to the ESKAPE group, with the minimum inhibitory concentration < 0.03 μg/mL for most Gram-positive strains and 4–16 μg/mL against Gram-negative E. coli, Acinetobacter baumannii, Pseudomonas aeruginosa, and Klebsiella pneumoniae.DNA gyrase B-IN-2 can be used for the research of infection .
|
-
- HY-17520
-
MTF-753
|
Fungal
|
Infection
|
Penthiopyrad (MTF-753) is a chiral carboxamide antifungal agent with a broad spectrum of fungicidal activity. Penthiopyrad can be used for controlling foliar and soil-borne plants diseases on a broad range of agricultural crops and turfgrass .
|
-
- HY-B1484
-
Latamoxef sodium; Lamoxactam sodium; LY-127935 sodium
|
Beta-lactamase
Bacterial
Antibiotic
|
Infection
|
Moxalactam (Latamoxef) sodium salt is a synthetic oxa-β-lactam antibiotic. Moxalactam sodium salt has a broad spectrum of activity against Gram-positive and Gram-negative aerobic and anaerobic bacteria. Moxalactam sodium salt inhibits production of β-lactamases .
|
-
- HY-B1484A
-
Latamoxef; Lamoxactam; LY-127935
|
Beta-lactamase
Bacterial
Antibiotic
|
Infection
|
Moxalactam (Latamoxef) is a synthetic oxa-β-lactam antibiotic. Moxalactam has a broad spectrum of activity against Gram-positive and Gram-negative aerobic and anaerobic bacteria. Moxalactam inhibits production of β-lactamases .
|
-
- HY-N6735
-
OSI 2040
|
HDAC
Parasite
|
Infection
Cancer
|
Apicidin (OSI 2040) is a fungal metabolite, acts as an orally active histone deacetylase 7/8 (HDAC7/8) inhibitor, with antiparasitic activity and a broad spectrum antiproliferative activity. Apicidin can be used for cancer research .
|
-
- HY-B1282S
-
|
Isotope-Labeled Compounds
Bacterial
Parasite
Antibiotic
|
Infection
|
Sulfaquinoxaline-d4 is the deuterium labeled Sulfaquinoxaline. Sulfaquinoxaline is an antimicrobial for veterinary use, with activity against a broad spectrum of Gram-negative and Gram-positive bacteria. Sulfaquinoxaline is used to prevent coccidiosis and bacterial infections .
|
-
- HY-120203
-
|
Antibiotic
Bacterial
|
Infection
|
DA 1131 is an anionic Carbapenem antibiotic. DA 1131 has broad spectrum antibacterial activity for both gram-positive and gram-negative organisms. DA 1131 is resistant to degradation by various types of β-lactamases .
|
-
- HY-P10219
-
|
Bacterial
|
Infection
Inflammation/Immunology
|
Brevicidine analog 22 (22) exerts broad spectrum antimicrobial activity and excellent stability (t1/2 = 40.98 h), with MICs of 2-16 μM for gram-negative and gram-positive bacteria .
|
-
- HY-123047R
-
-
- HY-W698952S
-
|
Isotope-Labeled Compounds
|
Endocrinology
|
3β hydroxy Tibolone-d5 is deuterium labeled Tibolone. Tibolone is a broad spectrum gonadal steroid agonist with progestagenic, androgenic, and estrogenic activities. Tibolone can be used for postmenopausal osteoporosis research .
|
-
- HY-P5552
-
|
Bacterial
Parasite
Fungal
|
Infection
|
Melimine is a hybrid antimicrobial peptide of Melittin (HY-P0233) and Protamine. Melimine is active against P. aeruginosa and S. aureus. Melimine has broad spectrum activity against bacteria, fungi and protozoa .
|
-
- HY-B0608
-
|
Antibiotic
Bacterial
Necroptosis
Apoptosis
|
Infection
|
Chlorhexidine digluconate (20% in water) is a orally active cationic antimicrobial agent that targets microbial cell membranes. Chlorhexidine digluconate (20% in water) binds to cell membrane phospholipids non-specifically, destroys membrane structure and induces leakage of cell contents. Chlorhexidine digluconate (20% in water) has broad-spectrum bactericidal activity against both Gram-positive and Gram-negative bacteria. Chlorhexidine digluconate (20% in water) can interfere with membrane permeability, cause protein precipitation and energy metabolism disorders, such as rapid inhibition of microbial growth and induction of cell death (necrosis or apoptosis) .
|
-
- HY-14865R
-
PTK 0796 (Standard); Amadacycline (Standard)
|
Reference Standards
Bacterial
Antibiotic
|
Infection
|
Omadacycline (Standard) is the analytical standard of Omadacycline. This product is intended for research and analytical applications. Omadacycline (PTK 0796), a first-in-class orally active aminomethylcycline antibacterial, is a member of the tetracycline class of antibiotics. Omadacycline acts through the inhibition of bacterial protein synthesis by binding to the 30S ribosomal subunit. Omadacycline possesses broad-spectrum antibacterial activity against aerobic and anaerobic Gram-positive and Gram-negative bacteria, as well as atypical bacteria. Omadacycline can be used for the research of acute bacterial skin and skin-structure infections, community-acquired pneumonia, and urinary tract infections .
|
-
- HY-14865CR
-
PTK0796 hydrochloride (Standard); Amadacycline hydrochloride (Standard)
|
Reference Standards
Bacterial
Antibiotic
|
Infection
|
Omadacycline (hydrochloride) (Standard) is the analytical standard of Omadacycline (hydrochloride). This product is intended for research and analytical applications. Omadacycline (PTK 0796) hydrochloride, a first-in-class orally active aminomethylcycline antibacterial, is a member of the tetracycline class of antibiotics. Omadacycline hydrochloride acts through the inhibition of bacterial protein synthesis by binding to the 30S ribosomal subunit. Omadacycline hydrochloride possesses broad-spectrum antibacterial activity against aerobic and anaerobic Gram-positive and Gram-negative bacteria, as well as atypical bacteria. Omadacycline hydrochloride can be used for the research of acute bacterial skin and skin-structure infections, community-acquired pneumonia, and urinary tract infections[1][2][3][4].
|
-
- HY-B1248R
-
|
Reference Standards
Antibiotic
Bacterial
Necroptosis
Apoptosis
|
Infection
|
Chlorhexidine (Standard) is the analytical standard of Chlorhexidine (HY-B1248). This product is intended for research and analytical applications. Chlorhexidine is a orally active cationic antimicrobial agent that targets microbial cell membranes. Chlorhexidine binds to cell membrane phospholipids non-specifically, destroys membrane structure and induces leakage of cell contents. Chlorhexidine has broad-spectrum bactericidal activity against both Gram-positive and Gram-negative bacteria. Chlorhexidine can interfere with membrane permeability, cause protein precipitation and energy metabolism disorders, such as rapid inhibition of microbial growth and induction of cell death (necrosis or apoptosis) .
|
-
- HY-175234
-
|
Virus Protease
|
Infection
|
CHIKV nsP2 protease-IN-2 (Compound 2o) is a allosteric nonstructural protein 2 helicase (nsP2hel) inhibitor with IC50s of 0.5 μM and 0.9 μM for nsP2 ATPase and RNA unwindase, respectively. CHIKV nsP2 protease-IN-2 has broad-spectrum antialphaviral activity against chikungunya virus (CHIKV), Mayaro virus (MAYV), and Venezuelan equine encephalitis virus (VEEV) (EC50 of 120 nM for CHIKV-nLuc). CHIKV nsP2 protease-IN-2 can be used for alphaviruses infections research .
|
-
- HY-156498
-
|
Ras
ERK
Raf
Ribosomal S6 Kinase (RSK)
AMPK
Apoptosis
PARP
|
Cancer
|
RMC-7977 is an orally active triple-complex RAS inhibitor that can simultaneously bind to cyclophilin A (CYPA) (Kd = 195 nM) and KRAS (G12V) (Kd = 292 μM). It exhibits broad-spectrum inhibitory activity against KRAS, NRAS, and HRAS proteins and their various wild-type and mutant variants. RMC-7977 induces apoptosis by inhibiting the phosphorylation of ERK, CRAF, and RSK, as well as increasing PARP cleavage. This leads to tumor regression, reduces resistance in KRAS G12C cancer models, and demonstrates good tolerability across various RAS cancer models .
|
-
- HY-B1145R
-
|
Reference Standards
Antibiotic
Bacterial
Necroptosis
Apoptosis
|
Infection
|
Chlorhexidine dihydrochloride (Standard) is the analytical standard of Chlorhexidine dihydrochloride (HY-B1145). This product is intended for research and analytical applications. Chlorhexidine dihydrochloride is a orally active cationic antimicrobial agent that targets microbial cell membranes. Chlorhexidine dihydrochloride binds to cell membrane phospholipids non-specifically, destroys membrane structure and induces leakage of cell contents. Chlorhexidine dihydrochloride has broad-spectrum bactericidal activity against both Gram-positive and Gram-negative bacteria. Chlorhexidine dihydrochloride can interfere with membrane permeability, cause protein precipitation and energy metabolism disorders, such as rapid inhibition of microbial growth and induction of cell death (necrosis or apoptosis) .
|
-
- HY-14865BR
-
PTK 0796 tosylate (Standard); Amadacycline tosylate (Standard)
|
Reference Standards
Bacterial
Antibiotic
|
Infection
|
Omadacycline (tosylate) (Standard) is the analytical standard of Omadacycline (tosylate). This product is intended for research and analytical applications. Omadacycline (PTK 0796) tosylate, a first-in-class orally active aminomethylcycline antibacterial, is a member of the tetracycline class of antibiotics. Omadacycline tosylate acts through the inhibition of bacterial protein synthesis by binding to the 30S ribosomal subunit. Omadacycline tosylate possesses broad-spectrum antibacterial activity against aerobic and anaerobic Gram-positive and Gram-negative bacteria, as well as atypical bacteria. Omadacycline tosylate can be used for the research of acute bacterial skin and skin-structure infections, community-acquired pneumonia, and urinary tract infections .
|
-
- HY-W013699R
-
|
Reference Standards
Antibiotic
Bacterial
Necroptosis
Apoptosis
|
Infection
|
Chlorhexidine diacetate (Standard) is the analytical standard of Chlorhexidine diacetate (HY-W013699). This product is intended for research and analytical applications. Chlorhexidine diacetate is a orally active cationic antimicrobial agent that targets microbial cell membranes. Chlorhexidine diacetate binds to cell membrane phospholipids non-specifically, destroys membrane structure and induces leakage of cell contents. Chlorhexidine diacetate has broad-spectrum bactericidal activity against both Gram-positive and Gram-negative bacteria. Chlorhexidine diacetate can interfere with membrane permeability, cause protein precipitation and energy metabolism disorders, such as rapid inhibition of microbial growth and induction of cell death (necrosis or apoptosis) .
|
-
- HY-B1158R
-
|
Reference Standards
Bacterial
Mas-related G-protein-coupled Receptor (MRGPR)
Interleukin Related
|
Infection
|
Imidazolidinyl urea (Standard) is the analytical standard of Imidazolidinyl urea. This product is intended for research and analytical applications. Imidazolidinyl urea is a commonly used antibacterial preservative in cosmetics and pharmaceuticals that releases formaldehyde through decomposition. Imidazolidinyl urea can also be used in the preparation of multifunctional hydrogels for the care of infectious wounds. Imidazolidinyl urea has broad-spectrum antibacterial activity, which mainly inhibits the reproduction of gram-negative bacteria and gram-positive bacteria, and restricts the growth of yeast and mold to a certain extent. Imidazolidinyl urea can induce non-histaminergic allergy by MRGPRX2 activation of mast cells .
|
-
- HY-B1190S2
-
BL-S 578-13C6
|
Isotope-Labeled Compounds
Bacterial
Antibiotic
EAAT
|
Infection
Neurological Disease
|
Cefadroxil- 13C6 (BL-S 578- 13C6) is 13C labeled Cefadroxil (HY-B1190). Cefadroxil is an orally active broad-spectrum cephalosporin antibiotic. Cefadroxil inhibits bacterial cell wall synthesis and enhances the expression of glutamate transporter-1. Cefadroxil is dependent on the intestinal peptide transporter PepT1 for small intestinal absorption. Cefadroxil has inhibitory and bactericidal activity against a variety of Gram-positive and Gram-negative bacteria and has analgesic effects on neuropathic pain .
|
-
- HY-W250308
-
Epsilon-polylysine (MW 3800-4200); ε-Polylysine (MW 3800-4200); ε-PL (MW 3800-4200)
|
Bacterial
|
Others
|
Epsilon-polylysine is an antimicrobial peptide that can be produced by bacteria such as Streptomyces. Epsilon-polylysine inhibits the growth of microorganisms such as bacteria, yeasts and molds and is therefore often used as a green food additive and preservative in various food and beverage products. Epsilon-polylysine has a variety of properties, including thermal stability, resistance to acidic conditions, and broad-spectrum antimicrobial activity. Epsilon-polylysine can be loaded on other materials to form nanoparticles or form nanofiber membranes for targeted delivery to exert sustained antibacterial efficacy. Epsilon-polylysine is also used as a liposome stabilizer .
|
-
- HY-171992
-
|
VEGFR
Caspase
Calcium Channel
|
Cancer
|
COX-2-IN-55 (compound 1) is an orally active, Celecoxib (HY-14398)-based analog with broad-spectrum anticancer activity and weak COX-2 inhibition. COX-2-IN-55 specifically inhibits SERCA2, increases caspase-3 cleavage and DR5 levels, thereby activating GRP78 and inhibiting the development of triple-negative breast cancer (TNBC). COX-2-IN-55 can also downregulate the levels of angiogenic markers VEGF-α and IL-8, inhibiting the formation of microvessels .
|
-
- HY-B0455R
-
SC47111A hydrochloride (Standard); NY-198 hydrochloride (Standard)
|
Reference Standards
Bacterial
Antibiotic
Topoisomerase
Reactive Oxygen Species (ROS)
Apoptosis
|
Infection
Endocrinology
Cancer
|
Lomefloxacin (hydrochloride) (Standard) is the analytical standard of Lomefloxacin hydrochloride (HY-B0455). This product is intended for research and analytical applications. Lomefloxacin hydrochloride (NY-198 hydrochloride) is an orally active difluoroquinolone antibiotic. Lomefloxacin hydrochloride prevents DNA supercoiling and replication by inhibiting bacterial topoisomerase II. Lomefloxacin hydrochloride induces ROS production and Apoptosis. Lomefloxacin hydrochloride has broad-spectrum bactericidal activity against Gram-positive and Gram-negative bacteria. Lomefloxacin hydrochloride has anticancer effects against melanoma. Lomefloxacin hydrochloride can be used in the study of systemic bacterial infections (such as Salmonella typhimurium infections), skin and melanoma .
|
-
- HY-122668
-
|
SARS-CoV
|
Infection
|
K22 is an inhibitor of coronavirus RNA synthesis that specifically targets membrane-associated coronavirus RNA synthesis. K22 effectively blocks replication of multiple coronaviruses by inhibiting the critical step of viral replication complex anchoring to host cell membranes to form double-membrane vesicles (DMVs). K22 exhibits broad-spectrum antiviral activity against diverse coronaviruses, including Middle East Respiratory Syndrome Coronavirus (MERS-CoV), Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV), Feline Coronavirus (FCoV), Mouse Hepatitis Virus (MHV), and Avian Infectious Bronchitis Virus (IBV) .
|
-
- HY-W738281
-
|
Isotope-Labeled Compounds
Antibiotic
Bacterial
Necroptosis
Apoptosis
|
Infection
|
Chlorhexidine-d8 is deuterium-labeled Chlorhexidine (HY-B1248) . Chlorhexidine is a orally active cationic antimicrobial agent that targets microbial cell membranes. Chlorhexidine binds to cell membrane phospholipids non-specifically, destroys membrane structure and induces leakage of cell contents. Chlorhexidine has broad-spectrum bactericidal activity against both Gram-positive and Gram-negative bacteria. Chlorhexidine can interfere with membrane permeability, cause protein precipitation and energy metabolism disorders, such as rapid inhibition of microbial growth and induction of cell death (necrosis or apoptosis) .
|
-
- HY-114784
-
Ingamine
|
Influenza Virus
|
Infection
|
Ingavirin (Ingamine) exhibits broad spectrum antiviral activities against human respiratory viruses, such as influenza virus A (IVA), human parainfluenza virus (hPIV) and human adenovirus (AdV). Ingavirin exhibits no toxixcity to mice at the dose of 3000 mg/kg .
|
-
- HY-17560
-
|
Antibiotic
Bacterial
|
Infection
Inflammation/Immunology
Cancer
|
Demeclocycline hydrochloride is an orally active tetracycline antibiotic that inhibits the binding of aminoacyl tRNA by binding to the 30S ribosomal subunit, thereby affecting protein synthesis. Demeclocycline hydrochloride exhibits antibacterial activity against a broad spectrum of bacterial infections .
|
-
- HY-B0420A
-
ABOB hydrochloride
|
Influenza Virus
HCV
HSV
Apoptosis
Caspase
|
Infection
|
Moroxydine (ABOB) hydrochloride is a broad-spectrum agent with multi-antiviral activities against DNA and RNA viruses, including influenza virus, herpes simplex, varicella zoster, measles, mumps disease, hepatitis C virus, etc. Moroxydine hydrochloride exhibits excellent antiviral activity and shows low cytotoxicity to cells infected by dsRNA viruses (grass carp reovirus, GCRV) and large DNA viruses (giant salamander iridovirus, GSIV). Moroxydine hydrochloride blocks the GCRV-induced cytopathic effects and eliminates nucleocapsids in ctenopharyngodon idella kidney (CIK) cells to keep the normal morphological structure. Moroxydine hydrochloride significantly inhibits the apoptosis, the caspase 3 activity, Bax expression and down-regulates Bcl-2 levels .
|
-
- HY-W016937
-
ABOB
|
Influenza Virus
HSV
HCV
Apoptosis
Caspase
|
Infection
Inflammation/Immunology
|
Moroxydine (ABOB) is a broad-spectrum agent with multi-antiviral activities against DNA and RNA viruses, including influenza virus, herpes simplex, varicella zoster, measles, mumps disease, hepatitis C virus, etc. Moroxydine exhibits excellent antiviral activity and shows low cytotoxicity to cells infected by dsRNA viruses (grass carp reovirus, GCRV) and large DNA viruses (giant salamander iridovirus, GSIV). Moroxydine blocks the GCRV-induced cytopathic effects and eliminates nucleocapsids in ctenopharyngodon idella kidney (CIK) cells to keep the normal morphological structure. Moroxydine significantly inhibits the apoptosis, the caspase 3 activity, Bax expression and down-regulates Bcl-2 levels [1][2][3].
|
-
- HY-174353
-
|
Cytochrome P450
Fungal
|
Infection
|
CYP51-IN-22 is a potent and broad-spectrum CYP51 inhibitor with a MIC80 of 1 μg/mL against Aspergillus fumigatum . CYP51-IN-22 is the non-deuterated form of CYP51-IN-23-d3 (HY-174353S). CYP51-IN-22 can prevent fungal phase transformation and biofilm formation. CYP51-IN-22 exhibits anti-drug resistance activity and fungal activity, and shows excellent safety for cells and significant pharmacological activity in mice. CYP51-IN-22 can be used for the study of invasive fungal infections (IFIs) .
|
-
- HY-126637
-
|
Bacterial
Fungal
|
Infection
|
Marasmic acid is a sesquiterpenoid with unsaturated dialdehyde functionality, first isolated from the Basidiomycete Marasmus conigenus. Marasmic acid has antibacterial, antifungal, cytotoxic and mutagenic activities, and its broad-spectrum activity is related to the α,β-unsaturated aldehyde group. However, its detailed biological mechanism of action has not been clarified. Previous studies have suggested that marasmic acid may exert its effects by reacting with endogenous nucleophiles or forming pyrrole derivatives. This study found that marasmic acid interferes with the membrane sensor histidine kinase MoSln1p of M. oryzae, superactivates the HOG pathway and causes cell death, indicating that its mechanism of action is different from other unsaturated dialdehyde sesquiterpenoids.
|
-
- HY-B0506R
-
OPC7251 (Standard)
|
Reference Standards
Bacterial
Antibiotic
DNA/RNA Synthesis
Interleukin Related
|
Infection
Inflammation/Immunology
|
Nadifloxacin (Standard) is the analytical standard of Nadifloxacin (HY-B0506). This product is intended for research and analytical applications. Nadifloxacin (OPC7251) is a broad-spectrum quinolone antibiotic. Nadifloxacin inhibits bacterial DNA gyrase and topoisomerase IV, interfering with DNA replication. It also suppresses the production of proinflammatory cytokines (such as IL-1α, IL-6, and IL-8). Nadifloxacin exhibits antibacterial activity against various pathogens, including Propionibacterium acnes and Staphylococcus aureus. Nadifloxacin also exhibits anti-inflammatory activity. Nadifloxacin can be used in the research of skin infections such as acne vulgaris, folliculitis, and impetigo .
|
-
- HY-B1825
-
|
Antibiotic
Bacterial
Beta-lactamase
|
Infection
|
Cefoxitin is a cephalosporin-class antibiotic. Cefoxitin is highly stable against β-Lactamase (HY-P2998). Cefoxitin has a broad spectrum of antibacterial activity, including Gram-negative and Gram-positive bacteria .
|
-
- HY-100506
-
|
Integrin
|
Cancer
|
GLPG0187 is a broad spectrum integrin receptor antagonist with antitumor activity; inhibits αvβ1-integrin with an IC50 of 1.3 nM . GLPG0187 inhibits migrasome biogenesis without cytotoxicity .
|
-
- HY-13685
-
HePC; Hexadecyl phosphocholine
|
Akt
HIV
Parasite
|
Infection
Cancer
|
Miltefosine is a broad spectrum antimicrobial, anti-leishmanial, phospholipid agent acting by inhibiting the PI3K/Akt activity . Miltefosine is an inhibitor of CTP-phosphocholine cytidyltransferase (CCT) .
|
-
- HY-B0126
-
|
Bacterial
Antibiotic
|
Infection
|
Marbofloxacin is a third generation fluoroquinolone and orally active antimicrobial agent, which has a broad spectrum bactericidal activity and good efficacy. Marbofloxacin can be used for the research of infections by Gram-positive and Gram-negative bacteria and Mycoplasma .
|
-
- HY-B0126A
-
|
Bacterial
Antibiotic
|
Infection
|
Marbofloxacin hydrochloride is a third generation fluoroquinolone and orally active antimicrobial agent, which has a broad spectrum bactericidal activity and good efficacy. Marbofloxacin hydrochloride can be used for the research of infections by Gram-positive and Gram-negative bacteria and Mycoplasma .
|
-
- HY-116144R
-
Lcaridin (Standard)
|
Reference Standards
Parasite
|
Infection
|
Picaridin (Standard) is the analytical standard of Picaridin. This product is intended for research and analytical applications. Picaridin (Lcaridin) is a broad spectrum arthropod repellent. The repellent and deterrent activities of Picaridin involve olfactory sensing in mosquitoes, and ticks, via their interactions with odorant receptor proteins .
|
-
- HY-B1256S
-
|
Isotope-Labeled Compounds
Bacterial
Antibiotic
|
Infection
|
Cefuroxime-d3 is deuterium labeled Cefuroxime (sodium). Cefuroxime sodium is an orally active second-generation cephalosporin antibiotic with increased stability to β-lactamase. Cefuroxime sodium has a broad spectrum activity against Gram-positive and Gram-negative bacteria .
|
-
- HY-17460B
-
BMS 284756 mesylate
|
Bacterial
Topoisomerase
Antibiotic
|
Infection
|
Garenoxacin (BMS 284756) mesylate is an orally active quinolone antibiotic and Garenoxacin mesylate has a broad spectrum of activity against a wide array of gram-positive and gram-negative bacteria, anaerobes. Garenoxacin mesylate also inhibits Gyrase and TOPO IV .
|
-
- HY-112543
-
|
Influenza Virus
|
Infection
|
S119-8 is a broad spectrum inhibitor of influenza A and B viruses, showing activity against multiple influenza B viruses and an oseltamivir-resistant influenza A virus, but does not inhibit a non-influenza virus, vesicular stomatitis nirus (VSV) .
|
-
- HY-P991608
-
7F11C7
|
Mucin
|
Cancer
|
CTM01 is a murine IgG1 (or humanized IgG4) monoclonal antibody inhibitor targeting MUC1. CTM01 has a broad spectrum anticancer activity against solid tumors of epithelial origin, such as breast, lung and ovarian cancer .
|
-
- HY-122502
-
Pirazofurin
|
DNA/RNA Synthesis
Antibiotic
Influenza Virus
HIV
SARS-CoV
|
Infection
Cancer
|
Pyrazofurin is an antitumor pyrimidine nucleoside analogue and a orotate-phosphoribosyltransferase inhibitor. Pyrazofurin inhibits cell proliferation and intracellular DNA synthesis by inhibiting uridine 5'-phosphate synthase. Pyrazofurin is also an antibiotic with a broad spectrum of antiviral activity .
|
-
- HY-121268A
-
|
Antibiotic
Bacterial
|
Infection
Inflammation/Immunology
Cancer
|
Demeclocycline calcium is an orally active tetracycline antibiotic that inhibits the binding of aminoacyl tRNA by binding to the 30S ribosomal subunit, thereby affecting protein synthesis. Demeclocycline calcium exhibits antibacterial activity against a broad spectrum of bacterial infections .
|
-
- HY-146358
-
|
Microtubule/Tubulin
|
Cancer
|
Anticancer agent 49 (compound 69) is a broad spectrum anticancer agent. Anticancer agent 49 inhibits tubulin polymerization. Anticancer agent 49 shows antiproliferative activity. Anticancer agent 49 has the potential for the research of solid and hematological tumors .
|
-
- HY-B1282R
-
|
Reference Standards
Bacterial
Parasite
Antibiotic
|
Infection
|
Sulfaquinoxaline (Standard) is the analytical standard of Sulfaquinoxaline. This product is intended for research and analytical applications. Sulfaquinoxaline is an antimicrobial for veterinary use, with activity against a broad spectrum of Gram-negative and Gram-positive bacteria. Sulfaquinoxaline is used to prevent coccidiosis and bacterial infections .
|
-
- HY-149155
-
|
Bacterial
|
Infection
|
o-Cymen-5-ol is a broad-spectrum antimicrobial agent with direct antimicrobial activity. o-Cymen-5-ol showed effective minimum inhibitory concentrations (MICs) against a variety of bacteria and fungi, such as Streptococcus mutans and Candida albicans. The combination of o-Cymen-5-ol and zinc showed synergistic effects, enhancing the inhibitory effect against oral pathogens. o-Cymen-5-ol was able to inhibit the glycolysis process and co-enhanced this effect with zinc. o-Cymen-5-ol showed a stronger antibacterial effect in toothpaste than placebo .
|
-
- HY-164388
-
|
Caspase
Apoptosis
Autophagy
Necroptosis
|
Cardiovascular Disease
Cancer
|
Z-VAD is an irreversible, broad-spectrum pan-caspase inhibitor that can inhibit a variety of caspases including caspase-3, -6, -7, -8, -9, etc. (with a weaker inhibitory effect on caspase-2). Z-VAD can block apoptosis signaling pathways, induce autophagy and necrosis in tumor cells, and has anti-angiogenic activity. Z-VAD can enhance the sensitivity of breast cancer and lung cancer cells to radiotherapy in vitro and in vivo, and prolong the growth delay of tumor xenograft models. Z-VAD is well tolerated and is mainly used in research related to cancer radiosensitization and cell death pathway regulation .
|
-
- HY-B1885S
-
|
Isotope-Labeled Compounds
Insecticide
Cholinesterase (ChE)
AMPK
PI3K
Akt
Apoptosis
SOD
|
Infection
|
Fenitrothion-d6 is the deuterium labeled Fenitrothion (HY-B1885). Fenitrothion is a broad-spectrum and orally active insecticide/acaricide. Fenitrothion inhibits cholinesterase, AMPKα and IRS1/PI3K/AKT. Fenitrothion causes Apoptosis, reduces SOD activity. Fenitrothion shows insecticidal effect against Rhyzopertha dominica and Tribolium castaneum adults. Fenitrothion is widely used in cotton crops, vegetable crops, fruit crops and field crops, especially rice. Fenitrothion can be used for brain and spleen toxicology studies .
|
-
- HY-W250308A
-
Epsilon-polylysine (hydrochloride) (MV 2000-5000); ε-Polylysine (hydrochloride) (MV 2000-5000); ε-PL (hydrochloride) (MV 2000-5000)
|
Bacterial
|
Infection
|
ε-Poly-L-lysine hydrochloride (MV 2000-5000) is an antimicrobial peptide that can be produced by bacteria such as Streptomyces. Epsilon-polylysine hydrochloride inhibits the growth of microorganisms such as bacteria, yeasts and molds and is therefore often used as a green food additive and preservative in various food and beverage products. Epsilon-polylysine hydrochloride has a variety of properties, including thermal stability, resistance to acidic conditions, and broad-spectrum antimicrobial activity. Epsilon-polylysine hydrochloride can be loaded on other materials to form nanoparticles or form nanofiber membranes for targeted delivery to exert sustained antibacterial efficacy. Epsilon-polylysine hydrochloride is also used as a liposome stabilizer .
|
-
- HY-172777
-
|
Succinate Dehydrogenase
Fungal
Reactive Oxygen Species (ROS)
MMP
|
Infection
|
SDH-IN-25 is a succinate dehydrogenase (SDH) inhibitor (IC50 = 4.82 mg/L). SDH-IN-25 exhibited broad-spectrum and potent antifungal activity. SDH-IN-25 mimics the interaction pattern of commercial fungicide Fluxapyroxad (HY-135549) through binding to SDH amino acid residues (TRP173, TYR58, and ARG43). SDH-IN-25 can induce hyphal morphology, interfere with respiratory metabolism by binding to complex II, generate reactive oxygen species (ROS), and affect mitochondrial membrane potential (MMP) in mycelia. SDH-IN-25 can be studied in research for agricultural disease control .
|
-
- HY-P3492
-
|
SARS-CoV
|
Infection
|
SARS-CoV-2-IN-34 (S-20-1) is a blood brain barrier penetrable pan-coronavirus (CoV) fusion inhibitor with broad-spectrum inhibitory activity. SARS-CoV-2-IN-34 effectively inhibits infection by pseudotyped and authentic SARS-CoV-2, and pseudotyped variants of concern (VOCs). SARS-CoV-2-IN-34 shows high affinity to RBD in S1 and HR1 domain in S2 of SARS-CoV-2 S protein. SARS-CoV-2-IN-34 can be used for the research of infection .
|
-
- HY-B0420AR
-
ABOB hydrochloride (Standard)
|
Influenza Virus
HCV
HSV
Apoptosis
Caspase
|
Infection
|
Moroxydine (ABOB) hydrochloride (Standard) is the analytical standard of Moroxydine (ABOB) hydrochloride (HY-B0420A). Moroxydine (ABOB) hydrochloride is a broad-spectrum agent with multi-antiviral activities against DNA and RNA viruses, including influenza virus, herpes simplex, varicella zoster, measles, mumps disease, hepatitis C virus, etc. Moroxydine hydrochloride exhibits excellent antiviral activity and shows low cytotoxicity to cells infected by dsRNA viruses (grass carp reovirus, GCRV) and large DNA viruses (giant salamander iridovirus, GSIV). Moroxydine hydrochloride blocks the GCRV-induced cytopathic effects and eliminates nucleocapsids in ctenopharyngodon idella kidney (CIK) cells to keep the normal morphological structure. Moroxydine hydrochloride significantly inhibits the apoptosis, the caspase 3 activity, Bax expression and down-regulates Bcl-2 levels.
|
-
- HY-119725R
-
|
Reference Standards
Insecticide
|
Infection
|
Tetradifon (Standard) is the analytical standard of Tetradifon (HY-119725). This product is intended for research and analytical applications. Tetradifon is a broad-spectrum organochlorine insecticide and an inhibitor of the mitochondrial oligomycin sensitivity conferring protein (OSCP), which can be used to control a variety of mites. Tetradifon inhibits energy-related activities such as ADP-stimulated respiration, DNP and Mg 2+-stimulated ATPase, with an IC50 of 4.5-27 nmoL/mg mitochondrial protein. Tetradifon exerts oligomycin-like activity by inhibiting the oxidative phosphorylation process, inducing oxidative stress and interfering with bone metabolism. Tetradifon is currently mainly used in the research of mitochondrial function regulation, bone remodeling mechanism and nephrotoxicity of environmental pollutants .
|
-
- HY-B0506S1
-
OPC7251-d5
|
Isotope-Labeled Compounds
Antibiotic
Bacterial
DNA/RNA Synthesis
Interleukin Related
|
Infection
Inflammation/Immunology
|
Nadifloxacin-d5 (OPC7251-d5) is deuterium labeled Nadifloxacin (HY-B0506). Nadifloxacin (OPC7251) is a broad-spectrum quinolone antibiotic. Nadifloxacin inhibits bacterial DNA gyrase and topoisomerase IV, interfering with DNA replication. It also suppresses the production of proinflammatory cytokines (such as IL-1α, IL-6, and IL-8). Nadifloxacin exhibits antibacterial activity against various pathogens, including Propionibacterium acnes and Staphylococcus aureus. Nadifloxacin also exhibits anti-inflammatory activity. Nadifloxacin can be used in the research of skin infections such as acne vulgaris, folliculitis, and impetigo .
|
-
- HY-P1630
-
|
Bacterial
|
Infection
|
Buforin II, derived from buforin I, a protein isolated from the stomach of the Asian toad Bufo bufo gargarizans, is a potent antimicrobial peptide. Buforin II has antimicrobial activity against a broad spectrum of Gram-positive and Gram-negative bacteria .
|
-
- HY-B0434R
-
Ribasphere (Standard)
|
Reference Standards
HCV
RSV
Orthopoxvirus
Antibiotic
|
Infection
Cancer
|
Ribavirin (Standard) is the analytical standard of Ribavirin. This product is intended for research and analytical applications. Ribavirin (ICN-1229) is an antiviral agent against a broad spectrum of viruses including HCV, HIVl, and RSV. Ribavirin also has anti-orthopoxvirus and anti-variola activities.
|
-
- HY-131165
-
|
Antibiotic
Bacterial
|
Infection
Cancer
|
Amoxicillin (trihydrate) mixture with potassium clavulanate (4:1) an antibiotic with good oral absorption and broad spectrum antimicrobial activity. Amoxicillin (trihydrate) mixture with potassium clavulanate (4:1) inhibits the biosynthesis of polypeptides in the cell wall, thereby inhibiting cell growth .
|
-
- HY-B1802CR
-
A-61827 tosylate (Standard)
|
Reference Standards
Antibiotic
Bacterial
|
Infection
|
Tosufloxacin (tosylate) (Standard) is the analytical standard of Tosufloxacin (tosylate). This product is intended for research and analytical applications. Tosufloxacin (A-61827) tosylate is an orally active fluoroquinolone antibiotic. Tosufloxacin tosylate shows a broad spectrum of antibacterial activity against gram-positive and gram-negative bacteria .
|
-
- HY-17460R
-
BMS284756 (Standard)
|
Reference Standards
Bacterial
Topoisomerase
DNA/RNA Synthesis
Antibiotic
|
Infection
|
Garenoxacin (Standard) is the analytical standard of Garenoxacin. This product is intended for research and analytical applications. Garenoxacin (BMS284756) is an orally active quinolone antibiotic and has a broad spectrum of activity against a wide array of gram-positive and gram-negative bacteria, anaerobes, and fastidious organisms .
|
-
- HY-B1802AR
-
A-61827 tosylate hydrate (Standard); T-3262 (Standard)
|
Reference Standards
Bacterial
Antibiotic
|
Infection
|
Tosufloxacin (tosylate hydrate) (Standard) is the analytical standard of Tosufloxacin (tosylate hydrate). This product is intended for research and analytical applications. Tosufloxacin tosylate hydrate (A-61827) is an orally active fluoroquinolone antibiotic. Tosufloxacin shows a broad spectrum of antibacterial activity against gram-positive and gram-negative bacteria[1][2].
|
-
- HY-B0467AR
-
Amoxycillin (Standard)
|
Reference Standards
Bacterial
Antibiotic
|
Infection
Cancer
|
Amoxicillin (Standard) is the analytical standard of Amoxicillin. This product is intended for research and analytical applications. Amoxicillin (Amoxycillin) is an antibiotic with good oral absorption and broad spectrum antimicrobial activity. Amoxicillin inhibits the biosynthesis of polypeptides in the cell wall, thereby inhibiting cell growth .
|
-
- HY-B0501
-
CP 76136-27
|
P-glycoprotein
Bacterial
Antibiotic
|
Infection
|
Danofloxacin mesylate (CP 76136-27) is a fluoroquinolone used as a veterinary drug. Danofloxacin mesylate has a broad spectrum of bactericidal activity, mainly inhibiting the DNA cycloenzyme of the bacteria. In addition, Danofloxacin mesylate is a substrate for ATP-dependent efflux transporters (P-gp and MRP2) .
|
-
- HY-B1117
-
MK-306
|
Bacterial
Antibiotic
Beta-lactamase
|
Infection
|
Cefoxitin sodium (MK-306) is a cephalosporin-class antibiotic. Cefoxitin sodium is highly stable against β-Lactamase (HY-P2998). Cefoxitin sodium has a broad spectrum of antibacterial activity, including Gram-negative and Gram-positive bacteria .
|
-
- HY-B0593
-
GR20263
|
Beta-lactamase
Bacterial
Antibiotic
|
Infection
Cancer
|
Ceftazidime (GR20263), an antibiotic, has a broad spectrum activity against Gram-positive and Gram-negative aerobic bacteria. Ceftazidime is also active against Enterobacteriaceae (including β-lactamase-positive strains) and is resistant to hydrolysis by most β-lactamases .
|
-
- HY-N1750R
-
|
Reference Standards
Tyrosinase
Endogenous Metabolite
|
Others
|
Garenoxacin (Standard) is the analytical standard of Garenoxacin. This product is intended for research and analytical applications. Garenoxacin (BMS284756) is an orally active quinolone antibiotic and has a broad spectrum of activity against a wide array of gram-positive and gram-negative bacteria, anaerobes, and fastidious organisms .
|
-
- HY-146357
-
|
Microtubule/Tubulin
|
Cancer
|
Anticancer agent 48 (compound 48) is a broad spectrum anticancer agent. Anticancer agent 48 inhibits tubulin polymerization. Anticancer agent 48 shows antiproliferative activity. Anticancer agent 48 shows antitumor activity in vivo. Anticancer agent 48 has the potential for the research of solid and hematological tumors .
|
-
- HY-108402R
-
|
Penicillin-binding protein (PBP)
Reference Standards
Bacterial
Antibiotic
|
Infection
|
Cefodizime (Standard) is the analytical standard of Cefodizime. This product is intended for research and analytical applications. Cefodizime is a third generation cephalosporin antibiotic with a broad spectrum of antibacterial activity. Cefodizime has no renal toxic effect, good tolerance and immune regulation activity, and has the potential for severe infections of the respiratory and urinary tracts .
|
-
- HY-B0724AR
-
T-3762 (Standard); Pazufloxacin methanesulfonate (Standard); Pazufloxacin mesilate (Standard)
|
Reference Standards
Bacterial
DNA/RNA Synthesis
|
Infection
|
Pazufloxacin (mesylate) (Standard) is the analytical standard of Pazufloxacin mesylate (HY-B0724A). This product is intended for research and analytical applications. Pazufloxacin mesylate is an orally active fluoroquinolone antimicrobial agent. Pazufloxacin mesylate inhibits DNA gyrase with IC50 values of 0.88 μg/mL (E. coli) and 1.9 μg/mL (P. aeruginosa). Pazufloxacin mesylate exhibits broad-spectrum antimicrobial activity, with MIC90 values ranging from 0.025 to 100 μg/mL against Gram-positive and Gram-negative bacteria, non-fermenting bacteria, Legionella spp., and anaerobic bacteria. Pazufloxacin mesylate is indicated for research on systemic infections, lung infections, urinary tract infections, and Legionella pneumonia .
|
-
- HY-N0168AR
-
|
Reference Standards
p38 MAPK
Apoptosis
Autophagy
Reactive Oxygen Species (ROS)
Bcl-2 Family
NF-κB
|
Neurological Disease
Cancer
|
(Rac)-Hesperetin (Standard) is the analytical standard of (Rac)-Hesperetin. This product is intended for research and analytical applications. (Rac)-Hesperetin is the racemate of Hesperetin. Hesperetin is a natural flavanone that can be found in citrus, and acts as a potent and orally active broad-spectrum inhibitor against human UGT activity. Hesperetin induces apoptosis via p38 MAPK activation. Hesperetin displays a range of bioactivities including antioxidant, anti-inflammatory, and anti-cancer. Hesperetin is found to induce cell-cycle arrest at G2/M phase. Hesperetin can reduce Bcl-2 and enhance BaxM. Hesperetin induces apoptosis through inhibiting NF-κB receptor .
|
-
- HY-B1885R
-
|
Reference Standards
Insecticide
Parasite
Cholinesterase (ChE)
AMPK
PI3K
Akt
Apoptosis
SOD
|
Infection
|
Fenitrothion (Standard) is the analytical standard of Fenitrothion (HY-B1885). This product is intended for research and analytical applications. Fenitrothion is a broad-spectrum and orally active insecticide/acaricide. Fenitrothion inhibits cholinesterase, AMPKα and IRS1/PI3K/AKT. Fenitrothion causes Apoptosis, reduces SOD activity. Fenitrothion shows insecticidal effect against Rhyzopertha dominica and Tribolium castaneum adults. Fenitrothion is widely used in cotton crops, vegetable crops, fruit crops and field crops, especially rice. Fenitrothion can be used for brain and spleen toxicology studies .
|
-
- HY-B0724BS
-
T3761-d4
|
Isotope-Labeled Compounds
Bacterial
DNA/RNA Synthesis
|
Infection
|
Pazufloxacin-d4 is deuterium labeled Pazufloxacin (HY-B0724B). Pazufloxacin is an orally active fluoroquinolone antimicrobial agent. Pazufloxacin inhibits DNA gyrase with IC50 values of 0.88 μg/mL (E. coli) and 1.9 μg/mL (P. aeruginosa). Pazufloxacin exhibits broad-spectrum antimicrobial activity, with MIC90 values ranging from 0.025 to 100 μg/mL against Gram-positive and Gram-negative bacteria, non-fermenting bacteria, Legionella spp., and anaerobic bacteria. Pazufloxacin is indicated for research on systemic infections, lung infections, urinary tract infections, and Legionella pneumonia .
|
-
- HY-P1222
-
|
Bacterial
|
Infection
|
LL-37, human is a 37-residue, amphipathic, cathelicidin-derived antimicrobial peptide, which exhibits a broad spectrum of antimicrobial activity. LL-37, human could help protect the cornea from infection and modulates wound healing .
|
-
- HY-B1256AR
-
Kefurox (Standard)
|
Beta-lactamase
Reference Standards
Bacterial
Antibiotic
|
Infection
Cancer
|
Cefuroxime (Standard) is the analytical standard of Cefuroxime. This product is intended for research and analytical applications. Cefuroxime is an orally active second-generation cephalosporin antibiotic with increased stability to β-lactamase. Cefuroxime has a broad spectrum activity against Gram-positive and Gram-negative bacteria .
|
-
- HY-P1222B
-
|
Bacterial
|
Infection
Inflammation/Immunology
|
LL-37, human acetate is a 37-residue, amphipathic, cathelicidin-derived antimicrobial peptide, which exhibits a broad spectrum of antimicrobial activity. LL-37, human acetate could help protect the cornea from infection and modulates wound healing .
|
-
- HY-B0467R
-
Amoxycillin sodium (Standard)
|
Reference Standards
Bacterial
Antibiotic
|
Infection
Cancer
|
Amoxicillin (sodium) (Standard) is the analytical standard of Amoxicillin (sodium). This product is intended for research and analytical applications. Amoxicillin (Amoxycillin) sodium is an antibiotic with good oral absorption and broad spectrum antimicrobial activity. Amoxicillin sodium inhibits the biosynthesis of polypeptides in the cell wall, thereby inhibiting cell growth[1][2][3].
|
-
- HY-B1256R
-
|
Beta-lactamase
Reference Standards
Bacterial
Antibiotic
|
Infection
|
Cefuroxime (sodium) (Standard) is the analytical standard of Cefuroxime (sodium). This product is intended for research and analytical applications. Cefuroxime sodium is an orally active second-generation cephalosporin antibiotic with increased stability to β-lactamase. Cefuroxime sodium has a broad spectrum activity against Gram-positive and Gram-negative bacteria .
|
-
- HY-B0529AR
-
Sodium azlocillin (Standard)
|
Reference Standards
Bacterial
Parasite
Antibiotic
|
Infection
|
Azlocillin (sodium salt) (Standard) is the analytical standard of Azlocillin (sodium salt). This product is intended for research and analytical applications. Azlocillin sodium salt (Sodium azlocillin), a semisynthetic penicillin, is a broad spectrum β-lactam antibiotic. Azlocillin sodium salt shows antipseudomonal activity, and also potent against the malarial parasite Plasmodium falciparum .
|
-
- HY-108325R
-
-
- HY-B1923S
-
-
- HY-157805
-
|
PROTACs
SARS-CoV
|
Infection
|
PROTAC SARS-CoV-2 Mpro degrader-2 (Compound 6) is a potent PROTAC degrader of SARS-CoV-2 M pro. PROTAC SARS-CoV-2 Mpro degrader-2 has broad-spectrum antiviral activity against CoVs, including SARS-CoV-2 (EC50 = 10.8 μM), HCoV-OC43 (EC50 = 1.6 μM) and HCoV-229E (EC50 = 6.5 μM). PROTAC SARS-CoV-2 Mpro degrader-2 exhibits potent activity against SARS-CoV-2 in Calu-3 cells, with an EC50 of 0.89 μM .
|
-
- HY-108402AR
-
|
Penicillin-binding protein (PBP)
Reference Standards
Bacterial
Antibiotic
|
Infection
|
Cefodizime (sodium) (Standard) is the analytical standard of Cefodizime (sodium). This product is intended for research and analytical applications. Cefodizime sodium is a third generation cephalosporin antibiotic with a broad spectrum of antibacterial activity. Cefodizime sodium has no renal toxic effect, good tolerance and immune regulation activity, and can be used for the research of severe infections of the respiratory and urinary tracts[1][2].
|
-
- HY-B0272S3
-
Rifampin-d11; Rifamycin AMP-d11
|
Isotope-Labeled Compounds
Antibiotic
Bacterial
Influenza Virus
Orthopoxvirus
|
Others
|
Rifampicin-d11 (Rifampin-d11; Rifamycin AMP-d11) is the deuterium labeled Rifampicin (HY-B0272) . Rifampicin is a potent and broad spectrum antibiotic against bacterial pathogens. Rifampicin has anti-influenza virus activities. Rifampicin shows anti-orthopoxvirus activity .
|
-
- HY-B0593A
-
GR20263 pentahydrate
|
Beta-lactamase
Bacterial
Antibiotic
|
Infection
Cancer
|
Ceftazidime (GR20263) pentahydrate , an antibiotic, has a broad spectrum activity against Gram-positive and Gram-negative aerobic bacteria. Ceftazidime pentahydrate is also active against Enterobacteriaceae (including β-lactamase-positive strains) and is resistant to hydrolysis by most β-lactamases .
|
-
- HY-167735
-
Bisdequalinium diacetate
|
Others
|
Infection
|
Salvizol (Bisdequalinium diacetate) is a chemotherapeutic agent with a broad spectrum of bactericidal activity, effective in the apical third of root canals. Salvizol possesses the ability to dissolve organic dentin matrix, facilitating mineralization and tubule exposure. Salvizol maintains a neutral pH, ensuring biological compatibility while exhibiting significant cleansing potency.
|
-
- HY-N2478
-
|
Autophagy
Parasite
|
Inflammation/Immunology
|
Taraxasteryl acetate is isolated from P. sagittalis,and has a broad spectrum of anti-inflammatory activity. Taraxasterol acetate promotes RNF31 degradation by activating autophagy. Taraxasteryl acetate relieves dextran, zymosan and arachidonic acid induced rat hind-paw edema. Taraxasteryl acetate can be used for the topical inflammation treatment [1] [2] .
|
-
- HY-B0226R
-
Nitrofural (Standard)
|
Reference Standards
Bacterial
Antibiotic
|
Infection
|
Nitrofurazone (Standard) is the analytical standard of Nitrofurazone. This product is intended for research and analytical applications. Nitrofurazone (Nitrofural) is a broad spectrum antibiotic that has oral activity. Nitrofurazone is a nitro-aromatic drug. Nitrofurazone is active against both Gram-positive and Gram-negative bacteria .
|
-
- HY-105098
-
BMS-180194; SQ 34514
|
HBV
HIV
CMV
EBV
Nucleoside Antimetabolite/Analog
|
Infection
|
Lobucavir (BMS-180194; SQ 34514),a nucleoside analogue,is an antiviral agent. Lobucavir shows a broad spectrum of activity against HBV,HIV/AIDS,and α,β,and γ herpes viruses including CMV,herpes-simplex,varicella-zoster,and Epstein-Barr virus .
|
-
- HY-B0771AR
-
SCE-2787 hydrochloride (Standard)
|
Reference Standards
Bacterial
Antibiotic
|
Infection
|
Cefozopran (hydrochloride) (Standard) is the analytical standard of Cefozopran (hydrochloride). This product is intended for research and analytical applications. Cefozopran (SCE-2787) hydrochloride is a semi-synthetic, parenteral, fourth-generation cephalosporin. Cefozopran hydrochloride, an antibiotic, has a broad spectrum of antibacterial activity, inhibiting most of the gram-negative and gram-positive organisms .
|
-
- HY-110039
-
|
EGFR
|
Infection
|
BIBX 1382 dihydrochloride is an ErbB kinase inhibitor with significant antiviral activity. BIBX 1382 affects the ability of viruses to enter host cells by inhibiting members of the ErbB kinase family. It can be used to study the interaction mechanism between virus and host and the broad spectrum intervention of highly pathogenic viruses .
|
-
- HY-19435A
-
|
iGluR
Cytochrome P450
|
Neurological Disease
|
GYKI-47261 dihydrochloride is a competitive, orally active, and selective AMPA receptor antagonist with an IC50 of 2.5 μM. GYKI-47261 has broad spectrum anticonvulsive activity and neuroprotective effects. GYKI-47261 dihydrochloride is also a potent inducer of CYP2E1 .
|
-
- HY-B0024
-
NM441
|
Bacterial
Antibiotic
|
Infection
|
Prulifloxacin (NM441) is an orally active fluoroquinolone antibiotic with a broad spectrum of activity against Gram-positive and -negative bacteria. Prulifloxacin is a proagent of a thiazeto-quinoline carboxylic acid derivative Ulifloxacin (NM394). Prulifloxacin has the potential for lower urinary tract infections and exacerbations of chronic bronchitis .
|
-
- HY-19435
-
|
iGluR
Cytochrome P450
|
Neurological Disease
|
GYKI-47261 is a competitive, orally active, and selective AMPA receptor antagonist with an IC50 of 2.5 μM. GYKI-47261 has broad spectrum anticonvulsive activity and neuroprotective effects. GYKI-47261 is also a potent inducer of CYP2E1 .
|
-
- HY-P1222A
-
|
Bacterial
|
Infection
|
LL-37, human TFA is a 37-residue, amphipathic, cathelicidin-derived antimicrobial peptide, which exhibits a broad spectrum of antimicrobial activity. LL-37, human TFA could help protect the cornea from infection and modulates wound healing .
|
-
- HY-B0434S1
-
-
- HY-W713297
-
ABOB hydrochloride-d8
|
Influenza Virus
Isotope-Labeled Compounds
HCV
HSV
Apoptosis
Caspase
|
Infection
|
Moroxydine hydrochloride-d8 (ABOB hydrochloride-d8) is the deuterium labeled Moroxydine (ABOB) hydrochloride (HY-B0420A). Moroxydine hydrochloride is a broad-spectrum agent with multi-antiviral activities against DNA and RNA viruses, including influenza virus, herpes simplex, varicella zoster, measles, mumps disease, hepatitis C virus, etc. Moroxydine hydrochloride exhibits excellent antiviral activity and shows low cytotoxicity to cells infected by dsRNA viruses (grass carp reovirus, GCRV) and large DNA viruses (giant salamander iridovirus, GSIV). Moroxydine hydrochloride blocks the GCRV-induced cytopathic effects and eliminates nucleocapsids in ctenopharyngodon idella kidney (CIK) cells to keep the normal morphological structure. Moroxydine hydrochloride significantly inhibits the apoptosis, the caspase 3 activity, Bax expression and down-regulates Bcl-2 levels [1][2][3].
|
-
- HY-15310
-
MK-933; CD-5024; K-237
|
Flavivirus
Dengue Virus
Parasite
HIV
Mitophagy
HSV
SARS-CoV
Antibiotic
Autophagy
Bacterial
|
Infection
Cancer
|
Ivermectin (MK-933) is a broad-spectrum anti-parasite agent. Ivermectin (MK-933) is a specific inhibitor of Impα/β1-mediated nuclear import and has potent antiviral activity towards both HIV-1 and dengue virus. It is a positive allosteric effector of P2X4 and the α7 neuronal nicotinic acetylcholine receptor (nAChRs). Ivermectin also inhibits bovine herpesvirus1 (BoHV-1) replication and inhibits BoHV-1 DNA polymerase nuclear import . Ivermectin is a candidate therapeutic against SARS-CoV-2/COVID-19 .
|
-
- HY-173411
-
|
Glycosidase
SARS-CoV
|
Infection
Inflammation/Immunology
|
DNJ-20 is an α-glucosidase inhibitor (IC50: 55.3 μg/mL). DNJ-20 has broad-spectrum anti-SARS-CoV-2 activity. DNJ-20 inhibits the correct processing of viral glycoproteins by interfering with the endoplasmic reticulum-associated glycoprotein folding process (ERQC), thereby blocking the formation and infection of viral particles. DNJ-20 has IC50 values up to 1.49 uM against several SARS-CoV-2 variants, as well as HCoV-229E and HCoV-0C43。DNJ-20 can be used for pan-coronavirus research .
|
-
- HY-B0126S
-
|
Isotope-Labeled Compounds
Bacterial
Antibiotic
|
Infection
|
Marbofloxacin-d8 is the deuterium labeled Marbofloxacin. Marbofloxacin is a third generation fluoroquinolone and orally active antimicrobial agent, which has a broad spectrum bactericidal activity and good efficacy. Marbofloxacin can be used for the research of infections by Gram-positive and Gram-negative bacteria and Mycoplasma .
|
-
- HY-13582A
-
|
Fungal
Parasite
|
Infection
Cancer
|
Carbendazim hydrochloride is a potent and orally active broad-spectrum?benzimidazole fungicide and can be acts as a pesticide for fungal diseases research, such as Seproria,?Fusarium?and?Sclerotina . Carbendazim hydrochloride is a benzimidazole (HY-Y1825) derivative with antitumor activity and used for cancer research, especially advanced solid tumors and lymphoma .
|
-
- HY-13582
-
|
Fungal
Parasite
|
Infection
Cancer
|
Carbendazim is a potent and orally active broad-spectrum benzimidazole fungicide and can be acts as a pesticide for fungal diseases research, such as Seproria, Fusarium and Sclerotina . Carbendazim is a benzimidazole (HY-Y1825) derivative with antitumor activity and used for cancer research, especially advanced solid tumors and lymphoma .
|
-
- HY-B0467BR
-
Amoxycillin trihydrate (Standard)
|
Reference Standards
Bacterial
Antibiotic
|
Infection
|
Amoxicillin (trihydrate) (Standard) is the analytical standard of Amoxicillin (trihydrate). This product is intended for research and analytical applications. Amoxicillin (Amoxycillin) trihydrateis an antibiotic with good oral absorption and broad spectrum antimicrobial activity. Amoxicillin trihydrateis inhibits the biosynthesis of polypeptides in the cell wall, thereby inhibiting cell growth .
|
-
- HY-17520R
-
MTF-753 (Standard)
|
Reference Standards
Fungal
|
Infection
|
Penthiopyrad (Standard) is the analytical standard of Penthiopyrad. This product is intended for research and analytical applications. Penthiopyrad (MTF-753) is a chiral carboxamide antifungal agent with a broad spectrum of fungicidal activity. Penthiopyrad can be used for controlling foliar and soil-borne plants diseases on a broad range of agricultural crops and turfgrass .
|
-
- HY-B1117R
-
MK-306 (Standard)
|
Reference Standards
Bacterial
Antibiotic
Beta-lactamase
|
Infection
|
Cefoxitin sodium (Standard) is the analytical standard of Cefoxitin sodium. This product is intended for research and analytical applications. Cefoxitin sodium is a cephalosporin-class antibiotic. Cefoxitin sodium is highly stable against β-Lactamase (HY-P2998). Cefoxitin sodium has a broad spectrum of antibacterial activity, including Gram-negative and Gram-positive bacteria.
|
-
- HY-161956
-
|
Filovirus
|
Infection
|
Antiviral agent 59 (compound 58) is an antiviral agent with selective and drug-like properties that inhibits a broad spectrum of filoviruses. Antiviral agent 59 exhibits low off-target activity and inhibition against replication-competent Ebola virus (EBOV), Sudan virus (SUDV), and Marburg virus (MARV/b>) .
|
-
- HY-B0126AS
-
|
Isotope-Labeled Compounds
Antibiotic
Bacterial
|
Infection
|
Marbofloxacin-d8 (hydrochloride) is deuterium labeled Marbofloxacin (hydrochloride). Marbofloxacin hydrochloride is a third generation fluoroquinolone and orally active antimicrobial agent, which has a broad spectrum bactericidal activity and good efficacy. Marbofloxacin hydrochloride can be used for the research of infections by Gram-positive and Gram-negative bacteria and Mycoplasma .
|
-
- HY-B2072AR
-
|
Reference Standards
Antibiotic
Bacterial
|
Infection
|
Cefadroxil (hydrate) (Standard) is the analytical standard of Cefadroxil (hydrate). This product is intended for research and analytical applications. Cefadroxil hydrate (BL-S 578 hydrate) is an orally active and first-generation cephalosporin with a broad spectrum antibacterial activity. Cefadroxil hydrate (BL-S 578 hydrate) also acts as a substrate of the peptide transporter PEPT1 and PEPT2 .
|
-
- HY-B0450S1
-
|
Isotope-Labeled Compounds
Fungal
Bacterial
Ferroptosis
Autophagy
|
Infection
Cancer
|
Ciclopirox-d11 (sodium) is deuterium labeled Ciclopirox. Ciclopirox (HOE296b) is a synthetic antifungal agent that can be used for superficial mycoses reseaech. Ciclopirox olamine has a very broad spectrum of activity and inhibits dermatophytes, yeasts, molds, and many Gram-positive and Gram-negative species pathogenic .
|
-
- HY-121969
-
|
HIV
|
Infection
|
DDX3-IN-2 is an active DEADbox polypeptide 3 (DDX3) inhibitor with an IC50 value of 0.3 μM. DDX3-IN-2 shows a broad spectrum of antiviral activity. DDX3-IN-2 has the potential to overcome HIV resistance .
|
-
- HY-106228
-
|
Fungal
Bacterial
Glutathione Peroxidase
|
Infection
|
HLF1-11, a human lactoferrin-derived peptide, is a broad spectrum antimicrobial agent. HLF1-11 inhibits human MPO activity. HLF1-11 also directs GM-CSF-driven monocyte differentiation toward macrophages, and enhances immune responses .
|
-
- HY-B0450S
-
HOE296b-d11
|
Fungal
Bacterial
Ferroptosis
Autophagy
|
Infection
Cancer
|
Ciclopirox-d11 is the deuterium labeled Ciclopirox. Ciclopirox (HOE296b) is a synthetic antifungal agent that can be used for superficial mycoses reseaech. Ciclopirox olamine has a very broad spectrum of activity and inhibits dermatophytes, yeasts, molds, and many Gram-positive and Gram-negative species pathogenic .
|
-
- HY-108325S
-
-
- HY-W779404
-
Ribasphere-13C2
|
Isotope-Labeled Compounds
RSV
HCV
Antibiotic
Orthopoxvirus
|
Cancer
|
Ribavirin- 13C2 (Ribasphere- 13C2) is the 13C-labeled Ribavirin (HY-B0434). Ribavirin (ICN-1229) is an antiviral agent against a broad spectrum of viruses including HCV, HIVl, and RSV. Ribavirin also has anti-orthopoxvirus and anti-variola activities.
|
-
- HY-B1825R
-
|
Reference Standards
Antibiotic
Bacterial
Beta-lactamase
|
Infection
|
Cefoxitin (Standard) is the analytical standard of Cefoxitin. This product is intended for research and analytical applications. Cefoxitin is a cephalosporin-class antibiotic. Cefoxitin is highly stable against β-Lactamase (HY-P2998). Cefoxitin has a broad spectrum of antibacterial activity, including Gram-negative and Gram-positive bacteria .
|
-
- HY-B0319R
-
UK-20349 (Standard)
|
Reference Standards
Fungal
Antibiotic
|
Infection
|
Tioconazole (Standard) is the analytical standard of Tioconazole. This product is intended for research and analytical applications. Tioconazole (UK-20349) is an antifungal imidazole derivative with broad spectrum activity. Tioconazole has inhibitory active aginst several dermatophytes and several yeasts with MIC50s <3.12 mg/L and <9 mg/L, respectively .
|
-
- HY-W011117S
-
|
Isotope-Labeled Compounds
Bacterial
DNA/RNA Synthesis
|
Infection
|
Danofloxacin-d3 is deuterium labeled Danofloxacin. Danofloxacin is a third generation fluoroquinolone and orally active antimicrobial agent. Danofloxacin shows a broad spectrum of activity against most Gram-negative and Gram-positive bacteria, mycoplasma and chlamydia species, and plays an antimicrobial role by inhibition of bacterial DNA-gyrase .
|
-
- HY-147703
-
|
Aurora Kinase
|
Cancer
|
Aurora kinase inhibitor-9 (compound 9d) is a potent AURKA/B dual aurora kinase inhibitor with IC50s of 0.093, 0.09 µM for Aurora A, Aurora B, respectively. Aurora kinase inhibitor-9 shows broad spectrum anti-proliferative activity .
|
-
- HY-14282
-
|
Fungal
|
Infection
Inflammation/Immunology
|
Lanoconazole is a potent and orally active imidazole antifungal agent, shows a broad spectrum of activity against fungi?in vitro?and?in vivo . Lanoconazole interferes with ergosterol biosynthesis by inhibiting sterol 14-alpha demethylase and blocking fungal membrane ergosterol biosynthesis. Lanoconazole can be used for the investigation of dermatophytosis and onychomycosis .
|
-
- HY-149407
-
|
VEGFR
CDK
EGFR
Necroptosis
Apoptosis
|
Cancer
|
Multi-kinase-IN-4 (compound 5d) is multi-targeted kinase inhibitor, including VEGFR2, EGFR, HER2, and CDK2, with IC50 values of 0.33, 0.22, 0.18 and 2.09 μM, respectively. Multi-kinase-IN-4 shows broad-spectrum anti-cancer activities against HepG2, MCF-7, MDA-231, and HeLa cell lines (IC50 = 1.94–7.1 µM), but exhibits lower toxicity in the WI-38 cells (IC50 = 40.85 µM). Multi-kinase-IN-4 induces apoptosis and arrests cell cycle at S phase in HepG2 cells. Multi-kinase-IN-4 has the potential for the research of cancer .
|
-
- HY-P10975
-
|
SARS-CoV
Influenza Virus
Enterovirus
|
Infection
|
P9R is an antiviral peptide. P9R has broad-spectrum antiviral activities against the coronaviruses (SARS-CoV-2, MERS-CoV and SARS-CoV), A(H1N1)pdm09, A(H7N9) virus, and rhinovirus. P9R directly binds to viruses and inhibits virus-host endosomal acidification. P9R significantly protects mice from A(H1N1)pdm09 infection without generating drug-resistant virus. P9R can be used for pH-dependent respiratory viruses research .
|
-
- HY-121195
-
PC-904
|
Bacterial
|
Infection
|
Apalcillin (PC-904) in combination with Ro 48-1220, a penam sulfone β-lactamase inhibitor, demonstrated broad-spectrum activity against gram-negative aerobic and anaerobic bacteria, excluding Klebsiella oxytoca. It exhibited potent activity against β-lactamase-producing Moraxella catarrhalis, Haemophilus influenzae, and Neisseria gonorrhoeae, with effective MICs (11 μg/mL). The combination also inhibited Pseudomonas aeruginosa, Stenotrophomonas maltophilia, and Acinetobacter species at low MICs (0.25 to 4 μg/mL). However, its efficacy against oxacillin-resistant staphylococci and certain gram-positive organisms was limited. Apalcillin/Ro 48-1220 showed comparable efficacy to piperacillin/tazobactam against some extended-spectrum β-lactamase-producing Escherichia coli but was less effective against SHV-type β-lactamases .
|
-
- HY-170924
-
|
Microtubule/Tubulin
Apoptosis
Mitosis
|
Cancer
|
Tubulin polymerization-IN-76 (compound 20b) is a potent and orally active Tubulin polymerization inhibitor. Tubulin polymerization-IN-76 inhibits Tubulin polymerization with an IC50 of 2.505 μM by acting on the colchicine binding site, thereby disrupting intracellular Microtubule networks and interfering with cell mitosis. Tubulin polymerization-IN-76 demonstrates exceptional efficacy against MGC-803 and HGC-27 cells with IC50s of 1.61 and 1.82 nM, respectively. Tubulin polymerization-IN-76 effectively inhibits the colony formation and cell migration activities, and induces G2/M phase cycle arrest and Apoptosis in MGC-803 and HGC-27 cells.Tubulin polymerization-IN-76 shows a broad-spectrum antiproliferative activity .
|
-
- HY-108716
-
CBS9106; SL-801
|
CRM1
Apoptosis
|
Cancer
|
CBS9106 (SL-801) is a reversible oral CRM1 inhibitor with CRM1 degrading and antitumor activities. CBS9106, inhibits CRM1-dependent nuclear export, causing arrest of the cell cycle and inducing apoptosis in a time- and dose-dependent manner for a broad spectrum of cancer cells .
|
-
- HY-W011117
-
|
Bacterial
DNA/RNA Synthesis
Antibiotic
|
Infection
|
Danofloxacin is a third generation fluoroquinolone and orally active antimicrobial agent. Danofloxacin shows a broad spectrum of activity against most Gram-negative and Gram-positive bacteria, mycoplasma and chlamydia species, and plays an antimicrobial role by inhibition of bacterial DNA-gyrase. Danofloxacinh has the potential for respiratory diseases in cattle, swine, and chickens treatment .
|
-
- HY-15433A
-
JNJ-26481585 dihydrochloride
|
HDAC
Apoptosis
Autophagy
|
Cancer
|
Quisinostat dihydrochloride (JNJ-26481585 dihydrochloride) is an orally available, potent pan-HDAC inhibitor with IC50s of 0.11 nM, 0.33 nM, 0.64 nM, 0.46 nM, and 0.37 nM for HDAC1, HDAC2, HDAC4, HDAC10 and HDAC11, respectively. Quisinostat dihydrochloride has a broad spectrum antitumoral activity .
|
-
- HY-B1805
-
3,4,4′-Trichlorocarbanilide
|
Bacterial
|
Infection
|
Triclocarban (3,4,4′-Trichlorocarbanilide), a broad spectrum antibacterial compound, is widely used in a broad range of applications such as the production of soaps, skin creams, toothpastes and deodorants. Triclocarban is a potential endocrine-disrupting chemical with the capacity to modulate androgen and estrogen activities as well as other hormone-mediated biological processes .
|
-
- HY-151159
-
|
Dihydrofolate reductase (DHFR)
EGFR
|
Cancer
|
DHFR-IN-4 is a potent dihydrofolate reductase (DHFR) inhibitor with an IC50 value of 123 nM. DHFR-IN-4 also has inhibitory activity against EGFR and HER2 with IC50s of 246 nM and 357 nM, respectively. DHFR-IN-4 has remarkable broad spectrum cytotoxic potency against cancer cells .
|
-
- HY-147246
-
HTD1801; BUDCA
|
Biochemical Assay Reagents
|
Metabolic Disease
|
Berberine ursodeoxycholate (HTD1801), an ionic salt of Berberine and Ursodeoxycholic acid, is an orally active and potent hypolipidemic agent. Berberine ursodeoxycholate shows significantly great reduction in liver fat content. Berberine ursodeoxycholate has a broad spectrum of metabolic activity. Berberine ursodeoxycholate can be used for the research of hyperlipidemia, non-alcoholic steatohepatitis (NASH) and diabetes .
|
-
- HY-B0126R
-
|
Reference Standards
Bacterial
Antibiotic
|
Infection
|
Marbofloxacin (Standard) is the analytical standard of Marbofloxacin. This product is intended for research and analytical applications. Marbofloxacin is a third generation fluoroquinolone and orally active antimicrobial agent, which has a broad spectrum bactericidal activity and good efficacy. Marbofloxacin can be used for the research of infections by Gram-positive and Gram-negative bacteria and Mycoplasma .
|
-
- HY-13685R
-
|
Akt
HIV
Parasite
|
Infection
Cancer
|
Miltefosine (Standard) is the analytical standard of Miltefosine. This product is intended for research and analytical applications. Miltefosine is a broad spectrum antimicrobial, anti-leishmanial, phospholipid agent acting by inhibiting the PI3K/Akt activity . Miltefosine is an inhibitor of CTP-phosphocholine cytidyltransferase (CCT) .
|
-
- HY-W011117S1
-
|
Isotope-Labeled Compounds
|
Others
|
Danofloxacin-d3-1 is deuterium labeled Danofloxacin. Danofloxacin is a third generation fluoroquinolone and orally active antimicrobial agent. Danofloxacin shows a broad spectrum of activity against most Gram-negative and Gram-positive bacteria, mycoplasma and chlamydia species, and plays an antimicrobial role by inhibition of bacterial DNA-gyrase .
|
-
- HY-B0220S
-
|
Bacterial
Antibiotic
|
Infection
|
Erythromycin-d6 is the deuterium labeled Erythromycin. Erythromycin is a macrolide antibiotic produced by actinomycete?Streptomyces erythreus?with a broad spectrum of antimicrobial activity. Erythromycin acts by binding to bacterial 50S ribosomal subunits and inhibits?RNA-dependent protein synthesis?by blockage of transpeptidation and/or translocation reactions, without affecting synthesis of nucleic acid .
|
-
- HY-18522
-
|
Phospholipase
|
Metabolic Disease
|
AA26-9 is a potent and broad spectrum serine hydrolase inhibitor. AA26-9 targets included serine peptidases, lipases, amidases, esterases, and thioesterases. AA26-9 shows inhibitory activity against approximately 1/3 of the 40+ serine hydrolases detected in immortalized T cell lines .
|
-
- HY-B0450
-
HOE296b
|
Fungal
Bacterial
Ferroptosis
Autophagy
|
Infection
Inflammation/Immunology
Cancer
|
Ciclopirox (HOE296b) is a synthetic and orally active antifungal agent that can be used for superficial mycoses reseaech. Ciclopirox olamine has a very broad spectrum of activity and inhibits dermatophytes, yeasts, molds, and many Gram-positive and Gram-negative species pathogenic. Ciclopirox also has anticancer and anti-inflammatory effect .
|
-
- HY-13685S1
-
HePC-d4; Hexadecyl phosphocholine-d4
|
Isotope-Labeled Compounds
Akt
Parasite
HIV
|
Infection
Cancer
|
Miltefosine-d4 (HePC-d4) is deuterium labeled Miltefosine. Miltefosine is a broad spectrum antimicrobial, anti-leishmanial, phospholipid agent acting by inhibiting the PI3K/Akt activity . Miltefosine is an inhibitor of CTP-phosphocholine cytidyltransferase (CCT) .
|
-
- HY-17560R
-
|
Reference Standards
Antibiotic
Bacterial
|
Infection
Inflammation/Immunology
Cancer
|
Demeclocycline hydrochloride (Standard) is the analytical standard of Demeclocycline hydrochloride (HY-17560). This product is intended for research and analytical applications. Demeclocycline hydrochloride is an orally active tetracycline antibiotic that inhibits the binding of aminoacyl tRNA by binding to the 30S ribosomal subunit, thereby affecting protein synthesis. Demeclocycline hydrochloride exhibits antibacterial activity against a broad spectrum of bacterial infections .
|
-
- HY-12651S
-
|
Isotope-Labeled Compounds
Parasite
|
Infection
|
Primaquine-d3 (diphosphate) is the deuterium labeled Primaquine diphosphate. Primaquine Diphosphate (Primaquine phosphate), an 8-aminoquinoline, exerts a broad spectrum of activities against various stages of parasitic malaria. Primaquine Diphosphate remains as the only agent that destroys late hepatic stages and latent tissue forms of Plasmodium vivax and Plasmodium ovale .
|
-
- HY-B0434G
-
Ribasphere; ICN-1229
|
Antibiotic
RSV
HCV
Orthopoxvirus
|
Infection
|
Ribavirin (GMP) is Ribavirin (HY-B0434) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Ribavirin (ICN-1229) is an antiviral agent against a broad spectrum of viruses including HCV, HIVl, and RSV. Ribavirin also has anti-orthopoxvirus and anti-variola activities.
|
-
- HY-B0593R
-
GR20263 (Standard)
|
Beta-lactamase
Reference Standards
Bacterial
Antibiotic
|
Infection
|
Ceftazidime (Standard) is the analytical standard of Ceftazidime. This product is intended for research and analytical applications. Ceftazidime (GR20263), an antibiotic, has a broad spectrum activity against Gram-positive and Gram-negative aerobic bacteria. Ceftazidime is also active against Enterobacteriaceae (including β-lactamase-positive strains) and is resistant to hydrolysis by most β-lactamases .
|
-
- HY-B0501R
-
CP 76136-27 (Standard)
|
Reference Standards
Bacterial
Antibiotic
|
Infection
|
Danofloxacin mesylate (Standard) is the analytical standard of Danofloxacin mesylate. This product is intended for research and analytical applications. Danofloxacin mesylate (CP 76136-27) is a fluoroquinolone used as a veterinary drug. Danofloxacin mesylate has a broad spectrum of bactericidal activity, mainly inhibiting the DNA cycloenzyme of the bacteria. In addition, Danofloxacin mesylate is a substrate for ATP-dependent efflux transporters (P-gp and MRP2) .
|
-
- HY-P3350
-
|
Bacterial
|
Infection
|
LS-BF1 is a stable and low toxic cationic antimicrobial peptide. LS-BF1 displays broad spectrum of antibacterial activity, including the challenging ESKAPE pathogens, by cell membrane disruptive mechanism. LS-BF1 shows good in vivo efficacy for elimination of bacteria in a mouse infection model[1].
|
-
- HY-135853
-
EIDD-2801; MK-4482
|
SARS-CoV
Influenza Virus
|
Infection
|
Molnupiravir (EIDD-2801) is an orally bioavailable proagent of the ribonucleoside analog EIDD-1931. Molnupiravir has broad spectrum antiviral activity against influenza virus and multiple coronaviruses, such as SARS-CoV-2, MERS-CoV, SARS-CoV. Molnupiravir has the potential for the research of COVID-19, and seasonal and pandemic influenza .
|
-
- HY-B0450A
-
Ciclopirox ethanolamine; HOE 296
|
Fungal
Bacterial
Ferroptosis
|
Infection
Cancer
|
Ciclopirox olamine (Ciclopirox ethanolamine) is a synthetic and orally active antifungal agent that can be used for superficial mycoses reseaech. Ciclopirox olamine has a very broad spectrum of activity and inhibits dermatophytes, yeasts, molds, and many Gram-positive and Gram-negative species pathogenic. Ciclopirox olamine also has anticancer and anti-inflammatory effect .
|
-
- HY-B0217
-
NTZ; NSC 697855
|
Parasite
Influenza Virus
Autophagy
|
Infection
Cancer
|
Nitazoxanide (NTZ), an anthelmintic agent, exhibits a broad spectrum of activities against a wide variety of helminths, protozoa, and enteric bacteria infecting animals and humans. Nitazoxanide inhibits Giardia lamblia trophozoite proliferation in axenic culture with an IC50 of 2.4 μM . Nitazoxanide can be used for the research of parasitic gastroenteritis. Nitazoxanide shows anti-Japanese encephalitis virus (JEV) activity in a mouse model .
|
-
- HY-15433
-
JNJ-26481585
|
HDAC
Apoptosis
Autophagy
|
Cancer
|
Quisinostat (JNJ-26481585) is a potent, second-generation and orally active pan-HDAC inhibitor (HDACi), with IC50 values ranging from 0.11 nM to 0.64 nM for HDAC1, HDAC2, HDAC4, HDAC10 and HDAC11. Quisinostat has a broad spectrum antitumoral activity . Quisinostat can induce autophagy in neuroblastoma cells .
|
-
- HY-162559
-
|
Fungal
|
Infection
|
SDH-IN-16 (compound 5aa) is a potent inhibitor of Succinate Dehydrogenase, with the IC50 of 1.62 μM. SDH-IN-16 displays a broad spectrum of antifungal activity against F. graminearum, B. cinerea, S. sclerotiorum, and R. solani, with the corresponding EC50 values of 0.12, 4.48, 0.33, and 0.15 μg/mL, respectively .
|
-
- HY-14282A
-
|
Fungal
|
Infection
Inflammation/Immunology
|
(Z)-Lanoconazole is the Z configuration of Lanoconazole. Lanoconazole is a potent and orally active imidazole antifungal agent, shows a broad spectrum of activity against fungi in vitro and in vivo . Lanoconazole interferes with ergosterol biosynthesis by inhibiting sterol 14-alpha demethylase and blocking fungal membrane ergosterol biosynthesis. Lanoconazole can be used for the investigation of dermatophytosis and onychomycosis .
|
-
- HY-13582S
-
|
Isotope-Labeled Compounds
Fungal
|
Infection
Cancer
|
Carbendazim-d4 is the deuterium labeled Carbendazim. Carbendazim is a potent and orally active broad-spectrum?benzimidazole fungicide and can be acts as a pesticide for fungal diseases research, such as Seproria,?Fusarium?and?Sclerotina . Carbendazim is a benzimidazole (HY-Y1825) derivative with antitumor activity and used for cancer research, especially advanced solid tumors and lymphoma .
|
-
- HY-P1629
-
|
Bacterial
Fungal
Antibiotic
|
Infection
|
Temporin A is a short alpha-helical antimicrobial peptide isolated from the skin of the frog Rana temporaria. Temporin A is effective against a broad spectrum of Gram-positive bacteria. Temporin A interacts directly with the cell membrane of the microorganism and it is non-toxic to erythrocytes at concentrations that are antimicrobial. Temporin A also has antifungal activities (against yeast-like Candida albicans) .
|
-
- HY-B0220
-
|
Bacterial
Antibiotic
DNA/RNA Synthesis
|
Infection
Cancer
|
Erythromycin is a macrolide antibiotic produced by actinomycete?Streptomyces erythreus?with a broad spectrum of antimicrobial activity. Erythromycin binds to bacterial 50S ribosomal subunits and inhibits?RNA-dependent protein synthesis?by blockage of transpeptidation and/or translocation reactions, without affecting synthesis of nucleic acid [1][2]. Erythromycin also exhibits antitumor and neuroprotective effect in different fields of research [3][4].
|
-
- HY-152157
-
|
HIV
|
Infection
|
HIV-1 inhibitor-52 is a potent broad-spectrum HIV-1 activity inhibitor with EC50s of 1.6 nM-6.4 nM for WT HIV-1, HIV-1 V370A, HIV-1 ΔV370, HIV-1 V362I/V370A, HIV-1 T332S/V362I/prR41G, HIV-1 A326T/V362I/V370A, HIV-1 R361K/V362I/L363M .
|
-
- HY-107330R
-
|
Reference Standards
Antibiotic
|
Others
|
(6R,7S)-Cefminox (sodium heptahydrate) (Standard) is the analytical standard of (6R,7S)-Cefminox (sodium heptahydrate). This product is intended for research and analytical applications. (6R,7S)-Cefminox sodium heptahydrate is an isomer of Cefminox sodium heptahydrate. Cefminox sodium heptahydrate is a β-lactam cephalosporin antibiotic, which exhibits a broad spectrum of antibacterial activity[1].
|
-
- HY-10254
-
PD0325901; PD325901
|
MEK
Autophagy
Apoptosis
|
Cancer
|
Mirdametinib (PD0325901) is an orally active, selective and non-ATP-competitive MEK inhibitor with an IC50 of 0.33 nM. Mirdametinib exhibits a Ki app of 1 nM against activated MEK1 and MEK2. Mirdametinib suppresses the expression of p-ERK1/2 and induces apoptosis. Mirdametinib has anti-cancer activity for a broad spectrum of human tumor xenografts .
|
-
- HY-N2478R
-
|
Autophagy
Reference Standards
|
Inflammation/Immunology
|
Taraxasteryl acetate (Standard) is the analytical standard of Taraxasteryl acetate. This product is intended for research and analytical applications. Taraxasteryl acetate is isolated from P. sagittalis,and has a broad spectrum of anti-inflammatory activity. Taraxasterol acetate promotes RNF31 degradation by activating autophagy. Taraxasteryl acetate relieves dextran, zymosan and arachidonic acid induced rat hind-paw edema. Taraxasteryl acetate can be used for the topical inflammation treatment .
|
-
- HY-B0593AR
-
GR20263 pentahydrate (Standard)
|
Beta-lactamase
Reference Standards
Bacterial
Antibiotic
|
Infection
Cancer
|
Ceftazidime (pentahydrate) (Standard) is the analytical standard of Ceftazidime (pentahydrate). This product is intended for research and analytical applications. Ceftazidime (GR20263) pentahydrate , an antibiotic, has a broad spectrum activity against Gram-positive and Gram-negative aerobic bacteria. Ceftazidime pentahydrate is also active against Enterobacteriaceae (including β-lactamase-positive strains) and is resistant to hydrolysis by most β-lactamases .
|
-
- HY-13582R
-
|
Parasite
Fungal
Reference Standards
|
Infection
Cancer
|
Carbendazim (Standard) is the analytical standard of Carbendazim. This product is intended for research and analytical applications. Carbendazim is a potent and orally active broad-spectrum benzimidazole fungicide and can be acts as a pesticide for fungal diseases research, such as Seproria, Fusarium and Sclerotina . Carbendazim is a benzimidazole (HY-Y1825) derivative with antitumor activity and used for cancer research, especially advanced solid tumors and lymphoma .
|
-
- HY-126193
-
|
NO Synthase
Apoptosis
Autophagy
Reactive Oxygen Species (ROS)
|
Cancer
|
JS-K is a NO donor that reacts with glutathione to generate NO at physiological pH. JS-K induces reactive oxygen species (ROS) to mediate apoptosis. JS-K induces autophagy. JS-K inhibits invasion. JS-K has a broad spectrum anti-proliferative activity in cancer cells. JS-K reduces tumor volume and causes necrosis of implanted tumors in mice .
|
-
- HY-B1805S
-
3,4,4′-Trichlorocarbanilide-d4
|
Bacterial
|
Infection
|
Triclocarban-d4 is the deuterium labeled Triclocarban. Triclocarban (3,4,4′-Trichlorocarbanilide), a broad spectrum antibacterial compound, is widely used in a broad range of applications such as the production of soaps, skin creams, toothpastes and deodorants. Triclocarban is a potential endocrine-disrupting chemical with the capacity to modulate androgen and estrogen activities as well as other hormone-mediated biological processes .
|
-
- HY-B0024R
-
NM441 (Standard)
|
Reference Standards
Bacterial
Antibiotic
|
Infection
|
Prulifloxacin (Standard) is the analytical standard of Prulifloxacin. This product is intended for research and analytical applications. Prulifloxacin (NM441) is an orally active fluoroquinolone antibiotic with a broad spectrum of activity against Gram-positive and -negative bacteria. Prulifloxacin is a proagent of a thiazeto-quinoline carboxylic acid derivative Ulifloxacin (NM394). Prulifloxacin has the potential for lower urinary tract infections and exacerbations of chronic bronchitis .
|
-
- HY-13582S1
-
|
Isotope-Labeled Compounds
Fungal
Parasite
|
Others
|
Carbendazimb-d3 is the deuterium labeled Carbendazimb (HY-13582). Carbendazim is a potent and orally active broad-spectrum?benzimidazole fungicide and can be acts as a pesticide for fungal diseases research, such as Seproria,?Fusarium?and?Sclerotina . Carbendazim is a benzimidazole (HY-Y1825) derivative with antitumor activity and used for cancer research, especially advanced solid tumors and lymphoma .
|
-
- HY-B0220S1
-
|
Isotope-Labeled Compounds
Bacterial
Antibiotic
|
Infection
|
Erythromycin- 13C,d3 is the 13C- and deuterium labeled Erythromycin. Erythromycin is a macrolide antibiotic produced by actinomycete?Streptomyces erythreus?with a broad spectrum of antimicrobial activity. Erythromycin acts by binding to bacterial 50S ribosomal subunits and inhibits?RNA-dependent protein synthesis?by blockage of transpeptidation and/or translocation reactions, without affecting synthesis of nucleic acid .
|
-
- HY-17508
-
|
Bacterial
Cytochrome P450
Autophagy
Antibiotic
|
Infection
Cancer
|
Clarithromycin has a broad spectrum of antimicrobial activity. Clarithromycin inhibits the CYP3A4-catalyzed triazolam alpha-hydroxylation with the IC50 (Ki) value of 56 (43) μM . Clarithromycin significantly inhibits the HERG potassium current .Clarithromycin affects the autophagic flux by impairing the signaling pathway linking hERG1 and PI3K .
|
-
- HY-B0220C
-
|
Antibiotic
Bacterial
DNA/RNA Synthesis
|
Infection
Cancer
|
Erythromycin aspartate is a macrolide antibiotic produced by actinomycete?Streptomyces erythreus?with a broad spectrum of antimicrobial activity. Erythromycin aspartate binds to bacterial 50S ribosomal subunits and inhibits?RNA-dependent protein synthesis?by blockage of transpeptidation and/or translocation reactions, without affecting synthesis of nucleic acid [1][2]. Erythromycin aspartate also exhibits antitumor and neuroprotective effect in different fields of research [3][4].
|
-
- HY-B0220A
-
|
Antibiotic
Bacterial
DNA/RNA Synthesis
|
Infection
Cancer
|
Erythromycin lactobionate is a macrolide antibiotic produced by actinomycete Streptomyces erythreus with a broad spectrum of antimicrobial activity. Erythromycin lactobionate binds to bacterial 50S ribosomal subunits and inhibits RNA-dependent protein synthesis by blockage of transpeptidation and/or translocation reactions, without affecting synthesis of nucleic acid [1][2]. Erythromycin lactobionate also exhibits antitumor and neuroprotective effect in different fields of research [3][4].
|
-
- HY-14282R
-
|
Reference Standards
Fungal
|
Infection
Inflammation/Immunology
|
Lanoconazole (Standard) is the analytical standard of Lanoconazole. This product is intended for research and analytical applications. Lanoconazole is a potent and orally active imidazole antifungal agent, shows a broad spectrum of activity against fungi in vitro and in vivo . Lanoconazole interferes with ergosterol biosynthesis by inhibiting sterol 14-alpha demethylase and blocking fungal membrane ergosterol biosynthesis. Lanoconazole can be used for the investigation of dermatophytosis and onychomycosis .
|
-
- HY-B0220F
-
|
Bacterial
Antibiotic
DNA/RNA Synthesis
|
Infection
Cancer
|
Erythromycin glutamate is a macrolide antibiotic produced by actinomycete Streptomyces erythreus with a broad spectrum of antimicrobial activity. Erythromycin glutamate binds to bacterial 50S ribosomal subunits and inhibits RNA-dependent protein synthesis by blockage of transpeptidation and/or translocation reactions, without affecting synthesis of nucleic acid [1][2]. Erythromycin glutamate also exhibits antitumor and neuroprotective effect in different fields of research [3][4].
|
-
- HY-B0220D
-
|
Bacterial
Antibiotic
DNA/RNA Synthesis
|
Infection
Cancer
|
Erythromycin thiocyanate is a macrolide antibiotic produced by actinomycete Streptomyces erythreus with a broad spectrum of antimicrobial activity. Erythromycin thiocyanate binds to bacterial 50S ribosomal subunits and inhibits RNA-dependent protein synthesis by blockage of transpeptidation and/or translocation reactions, without affecting synthesis of nucleic acid [1][2]. Erythromycin thiocyanate also exhibits antitumor and neuroprotective effect in different fields of research [3][4].
|
-
- HY-B0220B
-
|
Antibiotic
Bacterial
|
Infection
Cancer
|
Erythromycin gluceptate is a macrolide antibiotic produced by actinomycete Streptomyces erythreus with a broad spectrum of antimicrobial activity. Erythromycin gluceptate binds to bacterial 50S ribosomal subunits and inhibits RNA-dependent protein synthesis by blockage of transpeptidation and/or translocation reactions, without affecting synthesis of nucleic acid [1][2]. Erythromycin gluceptate also exhibits antitumor and neuroprotective effect in different fields of research [3][4].
|
-
- HY-173134
-
|
SARS-CoV
|
Infection
|
SARS-CoV-2 RdRp-IN-1 (Compound PAP-2) is a potent SARS-CoV-2 RdRp inhibitor, with an EC50 of 1.11 μM. SARS-CoV-2 RdRp-IN-1 can bind directly to SARS-CoV-2 RdRp, fully resistance to the exoribonuclease (ExoN) and exhibit broad spectrum anti-CoV activities .
|
-
- HY-B0220E
-
|
Bacterial
Antibiotic
DNA/RNA Synthesis
|
Infection
Cancer
|
Erythromycin A dihydrate is a macrolide antibiotic produced by actinomycete Streptomyces erythreus with a broad spectrum of antimicrobial activity. Erythromycin A dihydrate binds to bacterial 50S ribosomal subunits and inhibits RNA-dependent protein synthesis by blockage of transpeptidation and/or translocation reactions, without affecting synthesis of nucleic acid [1][2]. Erythromycin A dihydrate also exhibits antitumor and neuroprotective effect in different fields of research [3][4].
|
-
- HY-108875
-
|
Antibiotic
Bacterial
DNA/RNA Synthesis
|
Infection
Cancer
|
Erythromycin stearate is a macrolide antibiotic produced by actinomycete Streptomyces erythreus with a broad spectrum of antimicrobial activity. Erythromycin stearate binds to bacterial 50S ribosomal subunits and inhibits RNA-dependent protein synthesis by blockage of transpeptidation and/or translocation reactions, without affecting synthesis of nucleic acid [1][2]. Erythromycin stearate also exhibits antitumor and neuroprotective effect in different fields of research [3][4].
|
-
- HY-W231513
-
|
MASTL
Ser/Thr Protease
Aurora Kinase
|
Cancer
|
MASTL/Aurora A-IN-1 (Compound MA4) is a dual inhibitor of MASTL and Aurora A kinases with IC50 values of 0.56 μM and 0.16 μM, respectively. MASTL/Aurora A-IN-1 has broad-spectrum anticancer activity and has potent anticancer activity against SR (leukemia), K-562 (leukemia), MDA-MB-435 (melanoma), MOLT-4 (leukemia), and SK-MEL-2 (melanoma) cell lines in NCI-60 cancer cell lines with GI50 values of 0.023, 0.032, 0.037, 0.044, and 0.051 μM, respectively. MASTL/Aurora A-IN-1 inhibits Aurora A and MASTL kinases, inducing cell cycle G2/M arrest, thereby inhibiting cancer cell proliferation. MASTL/Aurora A-IN-1 can be used in cancer research, especially for tumors with dysregulated mitosis .
|
-
- HY-B0217R
-
NTZ (Standard); NSC 697855 (Standard)
|
Reference Standards
Parasite
Influenza Virus
Autophagy
|
Infection
Cancer
|
Nitazoxanide (Standard) is the analytical standard of Nitazoxanide. This product is intended for research and analytical applications. Nitazoxanide (NTZ), an anthelmintic agent, exhibits a broad spectrum of activities against a wide variety of helminths, protozoa, and enteric bacteria infecting animals and humans. Nitazoxanide inhibits Giardia lamblia trophozoite proliferation in axenic culture with an IC50 of 2.4 μM . Nitazoxanide can be used for the research of parasitic gastroenteritis. Nitazoxanide shows anti-Japanese encephalitis virus (JEV) activity in a mouse model .
|
-
- HY-176241
-
|
Others
|
Cardiovascular Disease
|
DC-174 is an orally active inhibitor of snake venom metalloproteinases (SVMP) with a broad spectrum of inhibitory activity against a variety of snake venom SVMPs. DC-174 acts directly on the active site of SVMPs via zinc-binding groups, inhibiting their enzymatic activity and procoagulant toxicity. DC-174 can significantly prolong the survival time of mice attacked by snake venom. DC-174 can be used in the study of first aid for snake bites .
|
-
- HY-163913
-
|
SARS-CoV
|
Infection
|
SARS-CoV-IN-5 (compound 49) is a highly selective, nonpeptidic and noncovalent 3CL pro inhibitor with IC50s of 38 nM, 21.1 nM and 86 nM for 3CL pro of SARS-CoV-1, SARS-CoV-2, Bat coronavirus WIV1, respectively. SARS-CoV-IN-5 inhibits the replication of the SARS-CoV-2 delta variant with an EC50 of 0.272 μM. SARS-CoV-IN-5 significantly reduces the lung viral copies in a K18-hACE2 transgenic mouse model. SARS-CoV-IN-5 has good target-specific and potential broad-spectrum anticoronavirus activities against SARS-CoV-1, WIV1, MERS, HCoV-OC43, HCoV-229E, and HKU9 .
|
-
- HY-124295
-
ABT-301; MPT0E028; TMU-C-0012
|
HDAC
Akt
Apoptosis
|
Inflammation/Immunology
Cancer
|
Imofinostat (ABT-301; MPT0E028) is an orally active and selective HDAC inhibitor with IC50s of 53.0 nM, 106.2 nM, 29.5 nM for HDAC1, HDAC2 and HDAC6, respectively. Imofinostat has a weak inhibitory effect on HDAC8 (IC50 of 2.5 μM), but no inhibitory effect on HDAC4 (IC50>10 μM). Imofinostat reduces the viability of B-cell lymphomas by inducing apoptosis and possesses potent direct Akt targeting ability and reduces Akt phosphorylation in B-cell lymphoma. Imofinostat has a broad-spectrum antitumor activity, including colorectal cancer, B-cell lymphoma, non-small cell lung carcinoma (NSCLC), and pancreatic cancer, while also showing therapeutic potential in non-tumor diseases like emphysema and pulmonary fibrosis .
|
-
- HY-135853S
-
EIDD-2801-d7; MK-4482-d7
|
SARS-CoV
Influenza Virus
|
Inflammation/Immunology
|
Molnupiravir-d7 is the deuterium labeled Molnupiravir. Molnupiravir (EIDD-2801) is an orally bioavailable prodrug of the ribonucleoside analog EIDD-1931. Molnupiravir has broad spectrum antiviral activity against influenza virus and multiple coronaviruses, such as SARS-CoV-2, MERS-CoV, SARS-CoV. Molnupiravir has the potential for the research of COVID-19, and seasonal and pandemic influenza .
|
-
- HY-W011117R
-
|
Reference Standards
Bacterial
DNA/RNA Synthesis
Antibiotic
|
Infection
|
Danofloxacin (Standard) is the analytical standard of Danofloxacin. This product is intended for research and analytical applications. Danofloxacin is a third generation fluoroquinolone and orally active antimicrobial agent. Danofloxacin shows a broad spectrum of activity against most Gram-negative and Gram-positive bacteria, mycoplasma and chlamydia species, and plays an antimicrobial role by inhibition of bacterial DNA-gyrase. Danofloxacinh has the potential for respiratory diseases in cattle, swine, and chickens treatment .
|
-
- HY-W585956
-
3,4,4′-Trichlorocarbanilide-13C6
|
Isotope-Labeled Compounds
|
Others
|
Triclocarban- 13C6 is the 13C labeled isotope of Triclocarban (HY-B1805). Triclocarban (3,4,4′-Trichlorocarbanilide), a broad spectrum antibacterial compound, is widely used in a broad range of applications such as the production of soaps, skin creams, toothpastes and deodorants. Triclocarban is a potential endocrine-disrupting chemical with the capacity to modulate androgen and estrogen activities as well as other hormone-mediated biological processes .
|
-
- HY-131165R
-
|
Antibiotic
Bacterial
|
Infection
Cancer
|
Amoxicillin (trihydrate) mixture with potassium clavulanate (4:1) (Standard) is the analytical standard of Amoxicillin (trihydrate) mixture with potassium clavulanate (4:1). This product is intended for research and analytical applications. Amoxicillin (trihydrate) mixture with potassium clavulanate (4:1) an antibiotic with good oral absorption and broad spectrum antimicrobial activity. Amoxicillin (trihydrate) mixture with potassium clavulanate (4:1) inhibits the biosynthesis of polypeptides in the cell wall, thereby inhibiting cell growth .
|
-
- HY-N7101S1
-
U-76,252-d6; CS-807-d6
|
Isotope-Labeled Compounds
Penicillin-binding protein (PBP)
Bacterial
Antibiotic
|
Infection
|
Cefpodoxime Proxetil-d6 (U-76,252-d6) is deuterium labeled Cefpodoxime Proxetil. Cefpodoxime proxetil is an orally administered broad spectrum third-generation cephalosporin. Cefpodoxime proxetil has anti-bacterial activity. Cefpodoxime proxetil binds to penicillin binding proteins (PBPs) which inhibits peptidoglycan synthesis, finally results in interfering bacterial cell wall biosynthesis .
|
-
- HY-B0220S2
-
|
Bacterial
DNA/RNA Synthesis
Antibiotic
|
Infection
|
Erythromycin-d3 is the deuterium labeled Erythromycin . Erythromycin is a macrolide antibiotic produced by actinomycete Streptomyces erythreus with a broad spectrum of antimicrobial activity. Erythromycin binds to bacterial 50S ribosomal subunits and inhibits RNA-dependent protein synthesis by blockage of transpeptidation and/or translocation reactions, without affecting synthesis of nucleic acid. Erythromycin also exhibits antitumor and neuroprotective effect in different fields of research .
|
-
- HY-135853R
-
EIDD-2801 (Standard); MK-4482 (Standard)
|
Reference Standards
SARS-CoV
Influenza Virus
|
Infection
|
Molnupiravir (Standard) is the analytical standard of Molnupiravir. This product is intended for research and analytical applications. Molnupiravir (EIDD-2801) is an orally bioavailable proagent of the ribonucleoside analog EIDD-1931. Molnupiravir has broad spectrum antiviral activity against influenza virus and multiple coronaviruses, such as SARS-CoV-2, MERS-CoV, SARS-CoV. Molnupiravir has the potential for the research of COVID-19, and seasonal and pandemic influenza .
|
-
- HY-B0450R
-
HOE296b (Standard)
|
Reference Standards
Fungal
Bacterial
Ferroptosis
Autophagy
|
Infection
Inflammation/Immunology
Cancer
|
Ciclopirox (Standard) is the analytical standard of Ciclopirox. This product is intended for research and analytical applications. Ciclopirox (HOE296b) is a synthetic and orally active antifungal agent that can be used for superficial mycoses reseaech. Ciclopirox olamine has a very broad spectrum of activity and inhibits dermatophytes, yeasts, molds, and many Gram-positive and Gram-negative species pathogenic. Ciclopirox also has anticancer and anti-inflammatory effect .
|
-
- HY-B0712A
-
Ro 13-9904 sodium hydrate
|
Bacterial
Antibiotic
GSK-3
Aurora Kinase
|
Infection
Cancer
|
Ceftriaxone sodium hydrate (Ro 13-9904 sodium hydrate) is a broad spectrum β-lactam third-generation cephalosporin antibiotic, which has good antibacterial activity against a variety of gram-negative and positive bacteria. Ceftriaxone sodium hydrate is a covalent inhibitor of GSK3β with IC50 value of 0.78 μM. Ceftriaxone sodium hydrate is an inhibitor of Aurora B. Ceftriaxone sodium hydrate has anti-inflammatory, antitumor and antioxidant activities. Ceftriaxone sodium hydrate can be used in the study of bacterial infections and meningitis .
|
-
- HY-B0712
-
Ro 13-9904 free acid
|
Bacterial
Antibiotic
GSK-3
Aurora Kinase
|
Infection
Inflammation/Immunology
Cancer
|
Ceftriaxone (Ro 13-9904 free acid) is a broad spectrum β-lactam third-generation cephalosporin antibiotic, which has good antibacterial activity against a variety of gram-negative and positive bacteria. Ceftriaxone is a covalent inhibitor of GSK3β with IC50 value of 0.78 μM. Ceftriaxone is an inhibitor of Aurora B. Ceftriaxone has anti-inflammatory, antitumor and antioxidant activities. Ceftriaxone can be used in the study of bacterial infections and meningitis .
|
-
- HY-B0712B
-
Ro 13-9904
|
Antibiotic
GSK-3
Bacterial
Aurora Kinase
|
Infection
Inflammation/Immunology
Cancer
|
Ceftriaxone sodium salt (Ro 13-9904) is a broad spectrum β-lactam third-generation cephalosporin antibiotic, which has good antibacterial activity against a variety of gram-negative and positive bacteria. Ceftriaxone sodium salt is a covalent inhibitor of GSK3β with IC50 value of 0.78 μM. Ceftriaxone sodium salt is an inhibitor of Aurora B. Ceftriaxone sodium salt has anti-inflammatory, antitumor and antioxidant activities. Ceftriaxone sodium salt can be used in the study of bacterial infections and meningitis .
|
-
- HY-W391625
-
(Rac)-Epiligulyl oxide
|
Fungal
|
Cancer
|
(Rac)-Dehydrocostus Lactone ((Rac)-Epiligulyl oxide) is a natural product with antiparasitic activity. (Rac)-Dehydrocostus Lactone can significantly inhibit the growth of Trypanosoma brucei rhodesiense. (Rac)-Dehydrocostus Lactone exhibits a broad spectrum of biological effects, including anti-inflammatory, anticancer, antiviral and antimicrobial activities. (Rac)-Dehydrocostus Lactone also has antifungal, antioxidant, antidiabetic, antiulcer and antihelminthic effects. (Rac)-Dehydrocostus Lactone exhibits different IC(50) values in cytotoxicity tests and has a high selectivity index .
|
-
- HY-173166
-
|
PPAR
|
Cancer
|
PPARγ agonist 17 (Compound C1) is a PPARγ agonist. PPARγ agonist 17 enhances PPARγ activity and blocks the cell cycle in G2/M phase, inhibits cell migration and induces apoptosis in HT-29 cells. PPARγ agonist 17 has a broad spectrum anti-proliferative activity in cancer cells with relatively low toxicity in normal cells which cannot cross the blood-brain barrier .
|
-
- HY-172891
-
|
CDK
HDAC
Apoptosis
|
Cancer
|
CDK9/HDAC1/HDAC3-IN-1 is dual-functional inhibitor of CDK9 and HDAC. CDK9/HDAC1/HDAC3-IN-1 inhibits the protein activity of CDK9/HDAC/HDAC3 with IC50 s of 0.17 μM, 1.73 μM and 1.11 μM for CDK9, HDAC1, and HDAC3, respectively. CDK9/HDAC1/HDAC3-IN-1 inhibits cancer cells by inducing cell apoptosis and cell cycle arrest in the G2/M phase, as well as tumor growth in a murine TNBC MDA-MB-231 xenograft model. CDK9/HDAC1/HDAC3-IN-1 has a broad-spectrum anti-cancer activity, such as breast cancer, cervical cancer, and liver cancer .
|
-
- HY-155522
-
|
Carbonic Anhydrase
|
Cancer
|
WES-1 (Compound 8g) is an inhibitor of carbonic anhydrase IX (Ki: 55.9 μM). WES-1 has broad spectrum anti-proliferative activity against the cancer cells, such as leukemia (K-562 and MOLT-4), non-small cell lung cancer (NCI–H460), colon cancer (HCT 116 and HCT-15) and melanoma (LOX IMVI) cell lines .
|
-
- HY-B0220R
-
|
Reference Standards
Bacterial
Antibiotic
DNA/RNA Synthesis
|
Infection
Cancer
|
Erythromycin (Standard) is the analytical standard of Erythromycin. This product is intended for research and analytical applications. Erythromycin is a macrolide antibiotic produced by actinomycete?Streptomyces erythreus?with a broad spectrum of antimicrobial activity. Erythromycin binds to bacterial 50S ribosomal subunits and inhibits?RNA-dependent protein synthesis?by blockage of transpeptidation and/or translocation reactions, without affecting synthesis of nucleic acid . Erythromycin also exhibits antitumor and neuroprotective effect in different fields of research .
|
-
- HY-174390
-
|
Fungal
Succinate Dehydrogenase
|
Infection
|
SDH-IN-29 (Compound A33) is a SDH inhibitor with an IC50 of 0.0709 μM. SDH-IN-29 has a broad spectrum of antifungal activities (EC50s of 0.356, 0.798 and 0.146 μg/mL for Fusarium graminearum, Sclerotinia sclerotiorum, and Rhizoctonia solani, respectively). SDH-IN-29 has moderate to significant protective effects against rice blast, wheat scab and cucumber powdery mildew .
|
-
- HY-B1805R
-
3,4,4′-Trichlorocarbanilide (Standard)
|
Reference Standards
Bacterial
|
Infection
Endocrinology
|
Triclocarban (Standard) (3,4,4′-Trichlorocarbanilide (Standard)) is the analytical standard of Triclocarban (HY-B1805). This product is intended for research and analytical applications. Triclocarban, a broad spectrum antibacterial compound, is widely used in a broad range of applications such as the production of soaps, skin creams, toothpastes and deodorants. Triclocarban is a potential endocrine-disrupting chemical with the capacity to modulate androgen and estrogen activities as well as other hormone-mediated biological processes .
|
-
- HY-139554A
-
KBP-7072 TFA
|
Bacterial
|
Infection
|
Zifanocycline (KBP-7072) TFA is an orally active, semi-synthetic aminomethylcycline antibiotic that inhibits the normal function of bacterial ribosomes. Zifanocycline TFA has broad spectrum in vitro antimicrobial activity against Gram-positive and Gram-negative bacteria, including many multidrug-resistant pathogens. Zifanocycline TFA is indicated for the study of acute bacterial skin and skin structure infections, community-acquired bacterial pneumonia, and complicated intra-abdominal infections .
|
-
- HY-B0450AG
-
Ciclopirox ethanolamine; HOE 296
|
Bacterial
Fungal
Ferroptosis
|
Infection
|
Ciclopirox (olamine) (GMP) is Ciclopirox olamine (HY-B0450A) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Ciclopirox (HOE296b) is a synthetic antifungal agent that can be used for superficial mycoses reseaech. Ciclopirox olamine has a very broad spectrum of activity and inhibits dermatophytes, yeasts, molds, and many Gram-positive and Gram-negative species pathogenic .
|
-
- HY-B0450AR
-
Ciclopirox ethanolamine (Standard); HOE 296 (Standard)
|
Reference Standards
Fungal
Bacterial
Ferroptosis
|
Infection
Cancer
|
Ciclopirox (olamine) (Standard) is the analytical standard of Ciclopirox (olamine). This product is intended for research and analytical applications. Ciclopirox olamine (Ciclopirox ethanolamine) is a synthetic and orally active antifungal agent that can be used for superficial mycoses reseaech. Ciclopirox olamine has a very broad spectrum of activity and inhibits dermatophytes, yeasts, molds, and many Gram-positive and Gram-negative species pathogenic. Ciclopirox olamine also has anticancer and anti-inflammatory effect .
|
-
- HY-176283
-
|
Microtubule/Tubulin
Histone Demethylase
Apoptosis
Wee1
Bcl-2 Family
Caspase
|
Cancer
|
Tubulin/LSD1-IN-1 is an effective dual inhibitor of Tubulin polymerization and LSD1 (IC50 = 1.72 μM). Tubulin/LSD1-IN-1 has broad-spectrum antiproliferative activity against cancer cell lines. Tubulin/LSD1-IN-1 inhibits tubulin polymerization by targeting colchicine binding sites, thereby disrupting the microtubule network in gastric cancer cells. Tubulin/LSD1-IN-1 increases the methylation levels of H3K4me1/2 and H3K9me2/3, thereby achieving epigenetic regulation. Tubulin/LSD1-IN-1 induces G2/M arrest, promotes apoptosis, and effectively inhibits colony formation of gastric cancer cells .
|
-
- HY-17508R
-
|
Reference Standards
Bacterial
Cytochrome P450
Autophagy
Antibiotic
|
Infection
Cancer
|
Clarithromycin (Standard) is the analytical standard of Clarithromycin. This product is intended for research and analytical applications. Clarithromycin has a broad spectrum of antimicrobial activity. Clarithromycin inhibits the CYP3A4-catalyzed triazolam alpha-hydroxylation with the IC50 (Ki) value of 56 (43) μM . Clarithromycin significantly inhibits the HERG potassium current .Clarithromycin affects the autophagic flux by impairing the signaling pathway linking hERG1 and PI3K .
|
-
- HY-151374
-
|
PKD
|
Cancer
|
3-IN-PP1 is a protein kinase D (PKD) inhibitor. 3-IN-PP1 has potent pan-PKD inhibitory activity for PKD1, PKD2 and PKD3 with IC50 values of 108, 94 and 108 nM, respectively. 3-IN-PP1 also is a broad spectrum anticancer agent and has inhibition of several tumor cells growth. 3-IN-PP1 can be used for the research of cancer .
|
-
- HY-103399R
-
|
Reference Standards
Bacterial
Topoisomerase
Antibiotic
|
Infection
|
Clarithromycin (Standard) is the analytical standard of Clarithromycin. This product is intended for research and analytical applications. Clarithromycin has a broad spectrum of antimicrobial activity. Clarithromycin inhibits the CYP3A4-catalyzed triazolam alpha-hydroxylation with the IC50 (Ki) value of 56 (43) μM . Clarithromycin significantly inhibits the HERG potassium current .Clarithromycin affects the autophagic flux by impairing the signaling pathway linking hERG1 and PI3K .
|
-
- HY-17508S1
-
|
Isotope-Labeled Compounds
Bacterial
Antibiotic
Autophagy
Cytochrome P450
|
Others
|
Clarithromycin-d3 is the deuterium labeled Clarithromycin (HY-17508) . Clarithromycin has a broad spectrum of antimicrobial activity. Clarithromycin inhibits the CYP3A4-catalyzed triazolam alpha-hydroxylation with the IC50 (Ki) value of 56 (43) μM . Clarithromycin significantly inhibits the HERG potassium current .Clarithromycin affects the autophagic flux by impairing the signaling pathway linking hERG1 and PI3K .
|
-
- HY-151095
-
|
Reactive Oxygen Species (ROS)
|
Others
|
Phytoene desaturase-IN-1 is a potent phytoene desaturase (PDS) inhibitor (Kd: 65.9 μM) through π−π stacking effect with Phe301 residue. Phytoene desaturase-IN-1 shows broad spectrum of postemergence herbicidal activity. Phytoene desaturase-IN-1 induces PDS mRNA reduction, phytoene and reactive oxygen species (ROS) accumulation in albino leaves. Phytoene desaturase-IN-1 can be used in the area of agricultural production .
|
-
- HY-173165
-
3-O-(6-Bromo-D-mannosyl)-28-acylamino-n-caproate methyl oleanolic acid
|
Phosphatase
Apoptosis
|
Cancer
|
OA-Br-1 is an orally active and selective inhibitor of PTP1B with an IC50 value of 7.08 μM. OA-Br-1 induces apoptosis. OA-Br-1 has broad spectrum anti-proliferative activity against cancer cells, and plays an anti-breast cancer role through the PTP1B/PI3K/AKT signaling pathway both in vitro and in vivo .
|
-
- HY-P11012
-
|
SARS-CoV
|
Infection
|
EK1 is a peptide-based fusion inhibitor of coronaviruses (CoVs) with broad spectrum inhibition to a number of CoV species. EK1 shows substantially improved pan-CoV fusion inhibitory activity. EK1 potently inhibits SARS-CoV-2. EK1 can form a stable six-helix bundle (6HB) structure with both short α-hCoV and long β-hCoV N-terminal heptad repeats .
|
-
- HY-139554
-
KBP-7072
|
Antibiotic
Bacterial
|
Infection
|
Zifanocycline (KBP-7072) is a semisynthetic third-generation aminomethylcycline antibiotic that inhibits the normal function of the bacterial ribosome. Zifanocycline exhibits a broad spectrum of in vitro antibacterial activity against Gram-positive and Gram-negative bacteria, including many multidrug-resistant pathogens. Zifanocycline is available in both oral and injectable formulations. Zifanocycline can be used for the research of acute bacterial skin and skin structure infections, community-acquired bacterial pneumonia, and complicated intra-abdominal infections .
|
-
- HY-P5057B
-
|
Fluorescent Dye
Bacterial
|
Infection
|
5-FAM-Ahx-LL-37 TFA is a 5-FAM (HY-66022) labeled LL-37, human (HY-P1222). The carboxyfluorescein group is attached via a 6-carbon spacer, 6-Aminohexanoic acid (Ahx, HY-B0236). LL-37, human is a 37-residue, amphipathic, cathelicidin-derived antimicrobial peptide, which exhibits a broad spectrum of antimicrobial activity .
|
-
- HY-D0027
-
Coumarin 120; AMC
|
Fluorescent Dye
Antibiotic
Fungal
|
Infection
|
7-Amino-4-methylcoumarin belongs to the coumarin class, can be isolated from the endophytic fungus Xylaria sp. and has a broad spectrum of antibacterial activity. 7-Amino-4-methylcoumarin is also commonly used as an important laser dye that emits in the blue region, capable of analyzing glycoprotein monosaccharides and N-linked oligosaccharides, and is also utilized in tissue pathology analysis, enzyme activity measurement, and copper ion detection. The excitation wavelength and emission wavelength are 351 nm and 430 nm, respectively.
|
-
- HY-W015490
-
|
DNA/RNA Synthesis
NF-κB
Monoamine Oxidase
TNF Receptor
Bacterial
|
Infection
Inflammation/Immunology
Cancer
|
1,4-Naphthoquinone is an inhibitor with broad-spectrum inhibitory activity targeting DNA polymerase, NF-κB and monoamine oxidase (MAO-A/B), with antibacterial and anti-biofilm efficacy. 1,4-Naphthoquinone is a competitive inhibitor of MAO-B (Ki=1.4 μM) and a non-competitive inhibitor of MAO-A (Ki=7.7 μM). 1,4-Naphthoquinone inhibits DNA polymerase pol α, β, γ, δ, ε, λ with IC50 ranging from 5.57-128 μM. 1,4-Naphthoquinone inhibits tumor cell proliferation, induces apoptosis and necrosis, and has anti-angiogenic and anti-inflammatory activities by inducing oxidative stress, depleting glutathione (GSH), inhibiting DNA polymerase-mediated DNA synthesis and blocking NF-κB nuclear translocation. 1,4-Naphthoquinone can be used in anti-bacterial , anti-tumor and anti-inflammatory studies, including inhibition of melanoma and colon cancer cell growth and endothelial cell function, as well as LPS-induced inflammation models .
|
-
- HY-B0147
-
Pefloxacinium
|
Antibiotic
Bacterial
Parasite
DNA/RNA Synthesis
Topoisomerase
|
Infection
Inflammation/Immunology
|
Pefloxacin is a broad spectrum antibiotic. Pefloxacin blocks DNA replication by inhibiting DNA gyrase. Pefloxacin inhibits DNA relaxation catalyzed by topoisomerase I with an IC50 of 45 μg/mL. Pefloxacin exhibits antibacterial activity against Escherichia coli, Pseudomonas aeruginosa, and Bacteroides fragilis with MIC90s of 0.12, 4, and 16 mg/L, respectively. Pefloxacin has anti-Plasmodium yoelii infection activity. Pefloxacin increase UVA-induced edema and immunesuppression. Pefloxacin can be used for infection studies .
|
-
- HY-B0712AR
-
Ro 13-9904 sodium hydrate (Standard)
|
Reference Standards
Bacterial
Antibiotic
GSK-3
Aurora Kinase
|
Infection
Cancer
|
Ceftriaxone (sodium hydrate) (Standard) is the analytical standard of Ceftriaxone (sodium hydrate). This product is intended for research and analytical applications. Ceftriaxone sodium hydrate (Ro 13-9904 sodium hydrate) is a broad spectrum β-lactam third-generation cephalosporin antibiotic, which has good antibacterial activity against a variety of gram-negative and positive bacteria. Ceftriaxone sodium hydrate is a covalent inhibitor of GSK3β with IC50 value of 0.78 μM. Ceftriaxone sodium hydrate is an inhibitor of Aurora B. Ceftriaxone sodium hydrate has anti-inflammatory, antitumor and antioxidant activities. Ceftriaxone sodium hydrate can be used in the study of bacterial infections and meningitis .
|
-
- HY-14532
-
CMX001; HDP-CDV
|
CMV
HSV
Orthopoxvirus
|
Infection
|
Brincidofovir (CMX001), the lipid-conjugated prodrug of Cidofovir (HY-17438), is an orally available, long-acting antiviral. Brincidofovir shows activity against a broad spectrum of DNA viruses including cytomegalovirus (CMV), adenovirus (ADV), varicella zoster virus, herpes simplex virus, polyomaviruses, papillomaviruses, poxviruses, and mixed double-stranded DNA virus infections. Brincidofovir, an oral antiviral in late stage development, has proven effective against orthopoxviruses in vitro and in vivo. .
|
-
- HY-B1805S1
-
3,4,4'-Trichlorocarbanilide-13C13
|
Isotope-Labeled Compounds
Bacterial
|
Infection
|
Triclocarban- 13C13 (3,4,4'-Trichlorocarbanilide- 13C13) is 13C labeled Triclocarban. Triclocarban (3,4,4′-Trichlorocarbanilide), a broad spectrum antibacterial compound, is widely used in a broad range of applications such as the production of soaps, skin creams, toothpastes and deodorants. Triclocarban is a potential endocrine-disrupting chemical with the capacity to modulate androgen and estrogen activities as well as other hormone-mediated biological processes .
|
-
- HY-B0220DR
-
|
Reference Standards
Bacterial
Antibiotic
DNA/RNA Synthesis
|
Infection
Cancer
|
Erythromycin (thiocyanate) (Standard) is the analytical standard of Erythromycin (thiocyanate). This product is intended for research and analytical applications. Erythromycin thiocyanate is a macrolide antibiotic produced by actinomycete Streptomyces erythreus with a broad spectrum of antimicrobial activity. Erythromycin thiocyanate binds to bacterial 50S ribosomal subunits and inhibits RNA-dependent protein synthesis by blockage of transpeptidation and/or translocation reactions, without affecting synthesis of nucleic acid[1][2]. Erythromycin thiocyanate also exhibits antitumor and neuroprotective effect in different fields of research[3][4].
|
-
- HY-15666
-
GZD824; HQP1351
|
Bcr-Abl
|
Cancer
|
Olverembatinib (GZD824) is a potent and orally active pan-Bcr-Abl inhibitor. Olverembatinib potently inhibits a broad spectrum of Bcr-Abl mutants. Olverembatinib strongly inhibits native Bcr-Abl and Bcr-Abl T315I with IC50s of 0.34 nM and 0.68 nM, respectively. Olverembatinib has antitumor activity . Olverembatinib is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-Y0136
-
|
Endogenous Metabolite
Influenza Virus
HSV
VSV
|
Infection
|
3-Indoleacetonitrile is an indole derivative with anti-influenza activity. 3-Indoleacetonitrile is a plant hormone produced by cruxiferous vegetables. 3-Indoleacetonitrile exerts profound antiviral activity against a broad spectrum of influenza A viruses, HSV-1 and VSV viruses in vitro. 3-Indoleacetonitrile diminishes lung virus titers and alleviates lung lesions in vivo. 3-Indoleacetonitrile induces an increase in mitochondrial antiviral-signaling (MAVS) protein levels. 3-Indoleacetonitrile can be used in research for combating viral infections including COVID-19, HSV-1, and VSV .
|
-
- HY-B0712R
-
Ro 13-9904 free acid (Standard)
|
Reference Standards
Bacterial
Antibiotic
GSK-3
Aurora Kinase
|
Infection
Inflammation/Immunology
Cancer
|
Ceftriaxone (Standard) is the analytical standard of Ceftriaxone. This product is intended for research and analytical applications. Ceftriaxone (Ro 13-9904 free acid) is a broad spectrum β-lactam third-generation cephalosporin antibiotic, which has good antibacterial activity against a variety of gram-negative and positive bacteria. Ceftriaxone is a covalent inhibitor of GSK3β with IC50 value of 0.78 μM. Ceftriaxone is an inhibitor of Aurora B. Ceftriaxone has anti-inflammatory, antitumor and antioxidant activities. Ceftriaxone can be used in the study of bacterial infections and meningitis[1][2][3][4][5][6][7].
|
-
- HY-B1839R
-
|
Reference Standards
Fungal
JNK
p38 MAPK
Bcl-2 Family
Caspase
Autophagy
Apoptosis
|
Infection
|
Fluazinam (Standard) is the analytical standard of Fluazinam (HY-B1839). This product is intended for research and analytical applications. Fluazinam is a broad spectrum pyridinamine fungal inhibitor. Fluazinam is an orally active dinitroaniline fungicide. Fluazinam induces phosphorylation of JNK, activates p38 pathway, decreases Bcl-2, activates caspase-3, decreases complex I activity, increases Autophagy and Apoptosis. Fluazinam has strong antifungal activity against F. fujikuroi and B. maydis. Fluazinam has a negative impact on Brachydanio rerio and worker bees .
|
-
- HY-12843
-
|
CDK
ERK
|
Cancer
|
Bohemine is a purine analogue and is a synthetic and selective CDK inhibitor with IC50s of 4.6 μM, 83 μM, and 2.7 μM for Cdk2/cyclin E, Cdk2/cyclin A, and Cdk9/cyclin T1, respectively. Bohemine also inhibits ERK2 with an IC50 of 52 μM and has less inhibitory effect on CDK1, CDK4 and CDK6. Bohemine has a broad spectrum anti-cancer activities .
|
-
- HY-15666A
-
GZD824 dimesylate; HQP1351 dimesylate
|
Bcr-Abl
|
Cancer
|
Olverembatinib (GZD824) dimesylate is a potent and orally active pan-Bcr-Abl inhibitor. Olverembatinib dimesylate potently inhibits a broad spectrum of Bcr-Abl mutants. Olverembatinib dimesylate strongly inhibits native Bcr-Abl and Bcr-Abl T315I with IC50s of 0.34 nM and 0.68 nM, respectively. Olverembatinib dimesylate has antitumor activity . Olverembatinib (dimesylate) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-173132
-
|
Aldose Reductase
|
Cancer
|
AKR1Cs-IN-1 (Compound 29) is a potent and broad-spectrum inhibitor targeting members of the Aldo-Keto Reductase 1C family (AKR1C1-1C4). By simultaneously occupying the SP2 and SP3 pockets, it effectively inhibits multiple isoforms and disrupts metabolic pathways associated with drug resistance. In enzymatic activity assays, AKR1Cs-IN-1 exhibited significant inhibitory potency, with IC50 values of 0.09, 0.28, 0.05, and 0.51 µM against AKR1C1, AKR1C2, AKR1C3, and AKR1C4, respectively. In the doxorubicin (DOX)-resistant breast cancer cell line MCF-7/ADR, AKR1Cs-IN-1 showed remarkable resensitization effects and significantly enhanced the cytotoxicity of DOX. AKR1Cs-IN-1 holds promise for research on overcoming drug resistance in breast cancer .
|
-
- HY-B0147S
-
Pefloxacinium-d5
|
Antibiotic
Bacterial
Isotope-Labeled Compounds
|
Others
|
Pefloxacin-d5 is the deuterium labeled Pefloxacin (HY-B0147). Pefloxacin is a broad spectrum antibiotic. Pefloxacin blocks DNA replication by inhibiting DNA gyrase. Pefloxacin inhibits DNA relaxation catalyzed by topoisomerase I with an IC50 of 45 μg/mL. Pefloxacin exhibits antibacterial activity against Escherichia coli, Pseudomonas aeruginosa, and Bacteroides fragilis with MIC90s of 0.12, 4, and 16 mg/L, respectively. Pefloxacin has anti-Plasmodium yoelii infection activity. Pefloxacin increase UVA-induced edema and immunesuppression. Pefloxacin can be used for infection studies .
|
-
- HY-15666R
-
GZD824 (Standard); HQP1351 (Standard)
|
Reference Standards
Bcr-Abl
|
Cancer
|
Olverembatinib (Standard) is the analytical standard of Olverembatinib. This product is intended for research and analytical applications. Olverembatinib (GZD824) is a potent and orally active pan-Bcr-Abl inhibitor. Olverembatinib potently inhibits a broad spectrum of Bcr-Abl mutants. Olverembatinib strongly inhibits native Bcr-Abl and Bcr-Abl T315I with IC50s of 0.34 nM and 0.68 nM, respectively. Olverembatinib has antitumor activity . Olverembatinib is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-139554AR
-
KBP-7072 TFA (Standard)
|
Bacterial
Antibiotic
Reference Standards
|
Infection
|
Zifanocycline (TFA) (Standard) is the analytical standard of Zifanocycline (TFA). This product is intended for research and analytical applications. Zifanocycline (KBP-7072) TFA is an orally active, semi-synthetic aminomethylcycline antibiotic that inhibits the normal function of bacterial ribosomes. Zifanocycline TFA has broad spectrum in vitro antimicrobial activity against Gram-positive and Gram-negative bacteria, including many multidrug-resistant pathogens. Zifanocycline TFA is indicated for the study of acute bacterial skin and skin structure infections, community-acquired bacterial pneumonia, and complicated intra-abdominal infections[1][2].
|
-
- HY-100427
-
CL29926; (±)-Imazamox
|
Acetolactate Synthase (ALS)
|
Others
|
Imazamox (CL29926) is a systemic herbicide that inhibits the production of acetolactate synthase (ALS) in plants with high selectivity, high activity, safety and broadspectrum activity, which would then inhibit plant growth and ultimately lead to plant death .
|
-
- HY-W015490S
-
|
Isotope-Labeled Compounds
DNA/RNA Synthesis
NF-κB
Monoamine Oxidase
TNF Receptor
Bacterial
|
Infection
Inflammation/Immunology
Cancer
|
1,4-Naphthoquinone-d6 is the deuterium labeled 1,4-Naphthoquinone. 1,4-Naphthoquinone is an inhibitor with broad-spectrum inhibitory activity targeting DNA polymerase, NF-κB and monoamine oxidase (MAO-A/B), with antibacterial and anti-biofilm efficacy. 1,4-Naphthoquinone is a competitive inhibitor of MAO-B (Ki=1.4 μM) and a non-competitive inhibitor of MAO-A (Ki=7.7 μM). 1,4-Naphthoquinone inhibits DNA polymerase pol α, β, γ, δ, ε, λ with IC50 ranging from 5.57-128 μM. 1,4-Naphthoquinone inhibits tumor cell proliferation, induces apoptosis and necrosis, and has anti-angiogenic and anti-inflammatory activities by inducing oxidative stress, depleting glutathione (GSH), inhibiting DNA polymerase-mediated DNA synthesis and blocking NF-κB nuclear translocation. 1,4-Naphthoquinone can be used in anti-bacterial , anti-tumor and anti-inflammatory studies, including inhibition of melanoma and colon cancer cell growth and endothelial cell function, as well as LPS-induced inflammation models .
|
-
- HY-B0712S1
-
Ro 13-9904-13C2,d3 triethylammonium salt
|
Antibiotic
Aurora Kinase
GSK-3
Bacterial
Isotope-Labeled Compounds
|
Infection
Inflammation/Immunology
Cancer
|
Ceftriaxone- 13C2,d3 triethylammonium salt is 13C and deuterated labeled Ceftriaxone (HY-B0712). Ceftriaxone (Ro 13-9904 free acid) is a broad spectrum β-lactam third-generation cephalosporin antibiotic, which has good antibacterial activity against a variety of gram-negative and positive bacteria. Ceftriaxone is a covalent inhibitor of GSK3β with IC50 value of 0.78 mM. Ceftriaxone is an inhibitor of Aurora B. Ceftriaxone has anti-inflammatory, antitumor and antioxidant activities. Ceftriaxone can be used in the study of bacterial infections and meningitis .
|
-
- HY-12169
-
BB2516; TA2516
|
MMP
|
Cancer
|
Marimastat (BB2516) is a broad spectrum and orally bioavailable inhibitor of MMPs, with potent activity against MMP-9 (IC50=3 nM), MMP-1 (IC50=5 nM), MMP-2 (IC50=6 nM), MMP-14 (IC50=9 nM) and MMP-7 (IC50=13 nM), used in the treatment of cancer. Marimastat (BB2516) is an angiogenesis and metastasis inhibitor, which limits the growth and production of blood vessels. As an antimetatstatic agent it prevents malignant cells from breaching the basement membranes .
|
-
- HY-170646
-
|
Influenza Virus
|
Infection
|
Influenza A virus-IN-15 (Compound 9b), a quinoline derivative, is a broad-spectrum inhibitor of influenza A viruses with acceptable cytotoxicity (IC50: 0.88-6.33 μM). Influenza A virus-IN-15 can inhibit the transcription and replication of viral RNA and is used in research for its antiviral effects against influenza A viruses (IAV) .
|
-
- HY-124309
-
|
Lactate Dehydrogenase
Apoptosis
|
Cancer
|
NHI-2 is a lactate dehydrogenase A (LDHA) inhibitor with an IC50 of 14.7 µM. NHI-2 shows selective for LDHA over LDHB (IC50 = 55.8 µM). NHI-2 is an efficient anti-glycolytic agent. NHI-2 enhances apoptosis, induces cell cycle arrest at S and G2 phases. NHI-2 has a broad spectrum anti-proliferative activity in cancer cells. NHI-2 affects extracellular acidification rate and ATP production. NHI-2 suppresses tumor growth in murine B78 melanoma tumor model .
|
-
- HY-Y0136R
-
|
Reference Standards
Endogenous Metabolite
Influenza Virus
HSV
VSV
|
Metabolic Disease
|
3-Indoleacetonitrile (Standard) is the analytical standard of 3-Indoleacetonitrile. This product is intended for research and analytical applications. 3-Indoleacetonitrile is an indole derivative with anti-influenza activity. 3-Indoleacetonitrile is a plant hormone produced by cruxiferous vegetables. 3-Indoleacetonitrile exerts profound antiviral activity against a broad spectrum of influenza A viruses, HSV-1 and VSV viruses in vitro. 3-Indoleacetonitrile diminishes lung virus titers and alleviates lung lesions in vivo. 3-Indoleacetonitrile induces an increase in mitochondrial antiviral-signaling (MAVS) protein levels. 3-Indoleacetonitrile can be used in research for combating viral infections including COVID-19, HSV-1, and VSV .
|
-
- HY-D0027R
-
|
Fluorescent Dye
Antibiotic
Fungal
|
Infection
|
7-Amino-4-methylcoumarin (Standard) is the analytical standard of 7-Amino-4-methylcoumarin. This product is intended for research and analytical applications. 7-Amino-4-methylcoumarin belongs to the coumarin class, can be isolated from the endophytic fungus Xylaria sp. and has a broad spectrum of antibacterial activity. 7-Amino-4-methylcoumarin is also commonly used as an important laser dye that emits in the blue region, capable of analyzing glycoprotein monosaccharides and N-linked oligosaccharides, and is also utilized in tissue pathology analysis, enzyme activity measurement, and copper ion detection. The excitation wavelength and emission wavelength are 351 nm and 430 nm, respectively. [4]
|
-
- HY-12169R
-
|
MMP
|
Cancer
|
Marimastat (Standard) is the analytical standard of Marimastat. This product is intended for research and analytical applications. Marimastat (BB2516) is a broad spectrum and orally bioavailable inhibitor of MMPs, with potent activity against MMP-9 (IC50=3 nM), MMP-1 (IC50=5 nM), MMP-2 (IC50=6 nM), MMP-14 (IC50=9 nM) and MMP-7 (IC50=13 nM), used in the treatment of cancer. Marimastat (BB2516) is an angiogenesis and metastasis inhibitor, which limits the growth and production of blood vessels. As an antimetatstatic agent it prevents malignant cells from breaching the basement membranes .
|
-
- HY-N7101
-
U-76,252; CS-807
|
Bacterial
Antibiotic
Penicillin-binding protein (PBP)
|
Infection
|
Cefpodoxime Proxetil is an orally active broad spectrum third-generation cephalosporin with potent antibacterial activity against both Gram-positive and Gram-negative bacteria including staphylococci, streptococci, Haemophilus influenzae, Neisseria gonorrhoeae, Escherichia coli, Klebsiella pnuemoniae, Citrobacter spp, and Proteus spp. Cefpodoxime Proxetil binds to penicillin binding proteins (PBPs), which inhibits peptidoglycan synthesis, finally results in interfering bacterial cell wall biosynthesis. Cefpodoxime Proxetil can be used against skin structure infections, acute otitis media, pharyngitis, tonsillitis, upper respiratory tract infection, urinary tract infections and sexually transmitted diseases .
|
-
- HY-100427R
-
CL29926 (Standard); (±)-Imazamox (Standard)
|
Reference Standards
Acetolactate Synthase (ALS)
|
Others
|
Imazamox (Standard) is the analytical standard of Imazamox. This product is intended for research and analytical applications. Imazamox (CL29926) is a systemic herbicide that inhibits the production of acetolactate synthase (ALS) in plants with high selectivity, high activity, safety and broadspectrum activity, which would then inhibit plant growth and ultimately lead to plant death .
|
-
- HY-100427S
-
CL29926-13C,d3; (±)-Imazamox-13C,d3
|
Acetolactate Synthase (ALS)
Isotope-Labeled Compounds
|
Others
|
Imazamox- 13C,d3 is the 13C- and deuterium labeled Imazamox. Imazamox (CL29926) is a systemic herbicide that inhibits the production of acetolactate synthase (ALS) in plants with high selectivity, high activity, safety and broadspectrum activity, which would then inhibit plant growth and ultimately lead to plant death .
|
-
- HY-N7101R
-
U-76,252 (Standard); CS-807 (Standard)
|
Reference Standards
Bacterial
Antibiotic
Penicillin-binding protein (PBP)
|
Infection
|
Cefpodoxime Proxetil (Standard) is the analytical standard of Cefpodoxime Proxetil. This product is intended for research and analytical applications. Cefpodoxime Proxetil is an orally active broad spectrum third-generation cephalosporin with potent antibacterial activity against both Gram-positive and Gram-negative bacteria including staphylococci, streptococci, Haemophilus influenzae, Neisseria gonorrhoeae, Escherichia coli, Klebsiella pnuemoniae, Citrobacter spp, and Proteus spp. Cefpodoxime Proxetil binds to penicillin binding proteins (PBPs), which inhibits peptidoglycan synthesis, finally results in interfering bacterial cell wall biosynthesis. Cefpodoxime Proxetil can be used against skin structure infections, acute otitis media, pharyngitis, tonsillitis, upper respiratory tract infection, urinary tract infections and sexually transmitted diseases .
|
-
- HY-113953
-
|
Caspase
Apoptosis
|
Inflammation/Immunology
|
Z-Asp-CH2-DCB is an irreversible broad spectrum caspase inhibitor. Z-Asp-CH2-DCB also inhibits proteases with caspase-like activity. Z-D-CH2-DCB blocks the production of IL-1β, TNF-α, IL-6, and IFN-γ in staphylococcal enterotoxin B (SEB)-stimulated peripheral blood mononuclear cells (PBMC), and reduces SEB-1-stimulated T-cell proliferation in a dose-dependent manner. Z-Asp-CH2-DCB prevents SU5416-induced septal cell apoptosis and emphysema development .
|
-
- HY-176268
-
RA-0188293; RA-NSP2-1
|
Virus Protease
Flavivirus
|
Infection
|
SGC-NSP2hel-1 (RA-0188293) is a potent, specific and orally active nsP2 inhibitor. SGC-NSP2hel-1 has broad spectrum activity against multiple alphaviruses of the nsP2 helicase with a CC50 > 250 µM.
SGC-NSP2hel-1 (RA-0188293) shows selectivity index > 4000 against human
RNA helicases. SGC-NSP2hel-1 reduces virus replication and limited virus-induced pathology by forming a stable complex with nsP2 and ATP in a preclinical small animal model of CHIKV disease.
|
-
- HY-12361
-
|
Parasite
|
Infection
|
PF 1022A is a cyclooctadepsipeptide with broadspectrum anthelmintic properties produced by fermentation of the fungus Mycelia sterilia. PF 1022A is a channel-forming ionophore. PF 1022A showes strong anthelmintic activities against Ascaridia galli in chickens. PF 1022A also can be used for angiostrongyliasis research .
|
-
- HY-12361R
-
|
Reference Standards
Parasite
|
Infection
|
PF 1022A (Standard) is the analytical standard of PF 1022A. This product is intended for research and analytical applications. PF 1022A is a cyclooctadepsipeptide with broadspectrum anthelmintic properties produced by fermentation of the fungus Mycelia sterilia. PF 1022A is a channel-forming ionophore. PF 1022A showes strong anthelmintic activities against Ascaridia galli in chickens. PF 1022A also can be used for angiostrongyliasis research[1][2][3].
|
-
- HY-N7101S
-
U-76-d7,252-d7; CS-807-d7
|
Isotope-Labeled Compounds
Bacterial
Antibiotic
Penicillin-binding protein (PBP)
|
Infection
|
Cefpodoxime proxetil-d7 (U-76-d7,252-d7; CS-807-d7) is the deuterium labeled Cefpodoxime Proxetil (HY-N7101). Cefpodoxime Proxetil is an orally active broad spectrum third-generation cephalosporin with potent antibacterial activity against both Gram-positive and Gram-negative bacteria including staphylococci, streptococci, Haemophilus influenzae, Neisseria gonorrhoeae, Escherichia coli, Klebsiella pnuemoniae, Citrobacter spp, and Proteus spp. Cefpodoxime Proxetil binds to penicillin binding proteins (PBPs), which inhibits peptidoglycan synthesis, finally results in interfering bacterial cell wall biosynthesis. Cefpodoxime Proxetil can be used against skin structure infections, acute otitis media, pharyngitis, tonsillitis, upper respiratory tract infection, urinary tract infections and sexually transmitted diseases .
|
-
- HY-B0837
-
MK-244
|
Parasite
GABA Receptor
Reactive Oxygen Species (ROS)
Apoptosis
|
Infection
Neurological Disease
|
Emamectin Benzoate (MK-244) is an orally active nervoussystem toxicant by binding g-aminobutyric (GABA) receptor in insects. Emamectin Benzoate is one of semi-synthetic derivative of Avermectin (HY-15311) with a broadspectrum of insecticidal and acaricidal activity. Emamectin Benzoate induces ROS-mediated DNA damage and cell apoptosis. Emamectin Benzoate, a mixture of the natural Emamectin B1a benzoate and Emamectin B1b benzoate, has the main component of Emamectin B1a benzoate .
|
-
Cat. No. |
Product Name |
Type |
-
- HY-15096
-
FJ-776
|
Dyes
|
MKT-077 (FJ-776), a highly water-soluble mitochondrial dye, has significant antitumor activity . MKT-077 exhibits low cytotoxicity, and inhibits broad-spectrum human cancer cell lines (colon cancer, breast cancer, pancreatic cancer). MKT-077 inhibits the growth of tumor in nude mice enograft tumor model. Ex/Em=488/543 nm .
|
-
- HY-D0027
-
Coumarin 120; AMC
|
Fluorescent Dyes/Probes
|
7-Amino-4-methylcoumarin belongs to the coumarin class, can be isolated from the endophytic fungus Xylaria sp. and has a broad spectrum of antibacterial activity. 7-Amino-4-methylcoumarin is also commonly used as an important laser dye that emits in the blue region, capable of analyzing glycoprotein monosaccharides and N-linked oligosaccharides, and is also utilized in tissue pathology analysis, enzyme activity measurement, and copper ion detection. The excitation wavelength and emission wavelength are 351 nm and 430 nm, respectively.
|
-
- HY-B0434G
-
Ribasphere (GMP); ICN-1229 (GMP)
|
Fluorescent Dye
|
Ribavirin (GMP) is Ribavirin (HY-B0434) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Ribavirin (ICN-1229) is an antiviral agent against a broad spectrum of viruses including HCV, HIVl, and RSV. Ribavirin also has anti-orthopoxvirus and anti-variola activities.
|
-
- HY-B0450AG
-
Ciclopirox ethanolamine (GMP); HOE 296 (GMP)
|
Fluorescent Dye
|
Ciclopirox (olamine) (GMP) is Ciclopirox olamine (HY-B0450A) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Ciclopirox (HOE296b) is a synthetic antifungal agent that can be used for superficial mycoses reseaech. Ciclopirox olamine has a very broad spectrum of activity and inhibits dermatophytes, yeasts, molds, and many Gram-positive and Gram-negative species pathogenic .
|
-
- HY-D0027R
-
|
Fluorescent Dyes/Probes
|
7-Amino-4-methylcoumarin (Standard) is the analytical standard of 7-Amino-4-methylcoumarin. This product is intended for research and analytical applications. 7-Amino-4-methylcoumarin belongs to the coumarin class, can be isolated from the endophytic fungus Xylaria sp. and has a broad spectrum of antibacterial activity. 7-Amino-4-methylcoumarin is also commonly used as an important laser dye that emits in the blue region, capable of analyzing glycoprotein monosaccharides and N-linked oligosaccharides, and is also utilized in tissue pathology analysis, enzyme activity measurement, and copper ion detection. The excitation wavelength and emission wavelength are 351 nm and 430 nm, respectively. [4]
|
Cat. No. |
Product Name |
Type |
-
- HY-138540
-
N-Dodecylimidazole
|
Cell Assay Reagents
|
1-Dodecylimidazole (N-Dodecylimidazole) is a lysosomotropic detergent and a cytotoxic agent. 1-Dodecylimidazole causes cell death by its acid-dependent accumulation in lysosomes, disruption of the lysosomal membrane, and releaseof cysteine proteases into the cytoplasm. 1-Dodecylimidazole has hypocholesterolaemic activity and broad-spectrum antifungal activity .
|
-
- HY-W250302
-
|
Biochemical Assay Reagents
|
Methylbenzethonium chloride is a quaternary ammonium compound commonly used as a preservative and disinfectant in a variety of personal care and healthcare products. Methylbenzethonium chloride has several properties that make it suitable for these applications, including its broad-spectrum antibacterial activity against bacteria, viruses and fungi. In addition, it is used as a preservative in cosmetic and pharmaceutical formulations to prevent the growth of microorganisms.
|
-
- HY-W250308
-
Epsilon-polylysine (MW 3800-4200); ε-Polylysine (MW 3800-4200); ε-PL (MW 3800-4200)
|
Cell Assay Reagents
|
Epsilon-polylysine is an antimicrobial peptide that can be produced by bacteria such as Streptomyces. Epsilon-polylysine inhibits the growth of microorganisms such as bacteria, yeasts and molds and is therefore often used as a green food additive and preservative in various food and beverage products. Epsilon-polylysine has a variety of properties, including thermal stability, resistance to acidic conditions, and broad-spectrum antimicrobial activity. Epsilon-polylysine can be loaded on other materials to form nanoparticles or form nanofiber membranes for targeted delivery to exert sustained antibacterial efficacy. Epsilon-polylysine is also used as a liposome stabilizer .
|
-
- HY-W250308A
-
Epsilon-polylysine (hydrochloride) (MV 2000-5000); ε-Polylysine (hydrochloride) (MV 2000-5000); ε-PL (hydrochloride) (MV 2000-5000)
|
Cell Assay Reagents
|
ε-Poly-L-lysine hydrochloride (MV 2000-5000) is an antimicrobial peptide that can be produced by bacteria such as Streptomyces. Epsilon-polylysine hydrochloride inhibits the growth of microorganisms such as bacteria, yeasts and molds and is therefore often used as a green food additive and preservative in various food and beverage products. Epsilon-polylysine hydrochloride has a variety of properties, including thermal stability, resistance to acidic conditions, and broad-spectrum antimicrobial activity. Epsilon-polylysine hydrochloride can be loaded on other materials to form nanoparticles or form nanofiber membranes for targeted delivery to exert sustained antibacterial efficacy. Epsilon-polylysine hydrochloride is also used as a liposome stabilizer .
|
-
- HY-W740053
-
|
Microbial Culture
|
Meropenem sodium is a carbapenem antibiotic with broad-spectrum antibacterial activity. Meropenem sodium has activity against susceptible and resistant N. gonorrhoeae (MIC value of 0.02-0.06 mg/mL), H. influenzae (MIC value of 0.03-0.12 mg/mL), and H. ducreyi (MIC value of 0.015-0.12 mg/mL) .
|
-
- HY-W250302R
-
|
Biochemical Assay Reagents
|
Methylbenzethonium (chloride) (Standard) is the analytical standard of Methylbenzethonium (chloride). This product is intended for research and analytical applications. Methylbenzethonium chloride is a quaternary ammonium compound commonly used as a preservative and disinfectant in a variety of personal care and healthcare products. Methylbenzethonium chloride has several properties that make it suitable for these applications, including its broad-spectrum antibacterial activity against bacteria, viruses and fungi. In addition, it is used as a preservative in cosmetic and pharmaceutical formulations to prevent the growth of microorganisms.
|
-
- HY-138540R
-
|
Cell Assay Reagents
|
1-Dodecylimidazole (Standard) is the analytical standard of 1-Dodecylimidazole. This product is intended for research and analytical applications. 1-Dodecylimidazole (N-Dodecylimidazole) is a lysosomotropic detergent and a cytotoxic agent. 1-Dodecylimidazole causes cell death by its acid-dependent accumulation in lysosomes, disruption of the lysosomal membrane, and releaseof cysteine proteases into the cytoplasm. 1-Dodecylimidazole has hypocholesterolaemic activity and broad-spectrum antifungal activity .
|
-
- HY-B0434G
-
Ribasphere (GMP); ICN-1229 (GMP)
|
Biochemical Assay Reagents
|
Ribavirin (GMP) is Ribavirin (HY-B0434) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Ribavirin (ICN-1229) is an antiviral agent against a broad spectrum of viruses including HCV, HIVl, and RSV. Ribavirin also has anti-orthopoxvirus and anti-variola activities.
|
-
- HY-B0450AG
-
Ciclopirox ethanolamine (GMP); HOE 296 (GMP)
|
Biochemical Assay Reagents
|
Ciclopirox (olamine) (GMP) is Ciclopirox olamine (HY-B0450A) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Ciclopirox (HOE296b) is a synthetic antifungal agent that can be used for superficial mycoses reseaech. Ciclopirox olamine has a very broad spectrum of activity and inhibits dermatophytes, yeasts, molds, and many Gram-positive and Gram-negative species pathogenic .
|
Cat. No. |
Product Name |
Target |
Research Area |
-
- HY-129034
-
|
Bacterial
Antibiotic
|
Infection
|
Ramoplanin is a broad-spectrum lipoglycodepsipeptide antibiotic derived from the Actinoplanes spp with with activity against gram-positive bacteria .
|
-
- HY-P10536
-
|
Bacterial
|
Infection
|
Temporin SHF is a broad-spectrum antimicrobial peptide that is active against Gram-positive and Gram-negative bacteria and yeasts, but does not have hemolytic activity. Temporin SHF disrupts the acyl chain stacking of anionic lipid bilayers, leading to cracks and disintegration of microbial membranes. Temporin SHF can be used in the development of antimicrobial drugs .
|
-
- HY-P5582
-
|
Bacterial
|
Infection
|
Combi-1 is an antimicrobial peptide with broad-spectrum activity against different bacteria and yeast cells .
|
-
- HY-P1612
-
|
Antibiotic
Bacterial
|
Infection
|
Hormaomycin is a potent and selective macrocyc antibiotic agent. Hormaomycin has broad-spectrum antibiotic activity against numerous Gram-positive .
|
-
- HY-P3349
-
|
Bacterial
|
Infection
|
c[Arg-Arg-Arg-Arg-Nal-Nal-Nal] (Compound 9C) shows broad-spectrum activity against drug-resistant Gram-positive and Gram-negative bacteria, with MICs of 3.1, 3,1, 12.5, and 25 μg/mL for MRSA (ATCC BAA-1556), S. aureus (ATCC 29213), P. aeruginosa (ATCC 27883), and E. coli (ATCC 25922), respectively .
|
-
- HY-P3348
-
|
Bacterial
|
Infection
|
c[Arg-Arg-Arg-Arg-Dip-Dip-Dip] (Compound 8C) shows broad-spectrum activity against drug-resistant Gram-positive and Gram-negative bacteria, with MICs of 3.1, 3,1, 12.5, and 12.5 μg/mL for MRSA (ATCC BAA-1556), S. aureus (ATCC 29213), P. aeruginosa (ATCC 27883), and E. coli (ATCC 25922), respectively .
|
-
- HY-P2794
-
-
- HY-P5691
-
|
Bacterial
|
Infection
Cancer
|
P1 is a broad-spectrum antimicrobial peptide. P1 shows antibacterial activity against Gram-positive and Gram-negative bacteria,such as B. anthracis spores and Carbapenem-resistant A. baumannii and K. pneumoniae .
|
-
- HY-P5561
-
|
Antibiotic
Bacterial
|
Infection
|
Aurein 2.2 is a major component of the skin secretion of L.aurea. Aurein 2.2 is an antibiotic with broad-spectrum antibacterial activity against Gram positive bacteria such as Staphylococcus aureus and S. epidermidis .
|
-
- HY-P10352
-
|
Bacterial
|
Infection
|
Pediocin PA-1 is a broad-spectrum lactic acid bacterial bacteriocin that inhibits the activity of foodborne pathogens such as Listeria monocytogenes and Gram-positive bacteria. Pediocin PA-1 can be used as a food biopreservative .
|
-
- HY-P10352A
-
|
Bacterial
|
Infection
|
Pediocin PA-1 TFA is a broad-spectrum lactic acid bacterial bacteriocin that inhibits the activity of foodborne pathogens such as Listeria monocytogenes and Gram-positive bacteria. Pediocin PA-1 TFA can be used as a food biopreservative .
|
-
- HY-18234
-
-
- HY-P2170
-
XOMA-629
|
Antibiotic
Bacterial
|
Infection
Inflammation/Immunology
|
XMP-629 (XOMA-629), a cationic α-helical peptide, is a potent endotoxin inhibitor. XMP-629 exhibits broad-spectrum antimicrobial activity via an immunomodulatory mechanism. XOMA 629 has antimicrobial activity against Propionibacterium acnes, Staphylococcus aureus and Streptococcus pyogenesand .
|
-
- HY-101399R
-
γ-Glutamylphenylalanine (Standard)
|
Reference Standards
Endogenous Metabolite
|
Others
|
Ceftezole (sodium) (Standard) is the analytical standard of Ceftezole (sodium). This product is intended for research and analytical applications. Ceftezole sodium (CTZ sodium) is a broad-spectrum cephem antibiotic against many species of gram-positive and gram-negative bacteria. Ceftezole sodium (CTZ sodium) is an alpha-glucosidase inhibitor with in vivo anti-diabetic activity .
|
-
- HY-P10228
-
|
Fungal
Bacterial
|
Infection
|
S-Thanatin is an insect antimicrobial peptide with potent broad-spectrum antibacterial activity. S-Thanatin can inhibit the activity of Gram-negative bacteria, Gram-positive bacteria, and fungi, without cytotoxicity. The antibacterial activity of S-Thanatin is not affected by PH value, but monovalent cations (Na +/K +) can reduce its antibacterial activity against Gram-negative bacteria in a dose-dependent manner .
|
-
- HY-P5724
-
|
Bacterial
|
Infection
|
Nv-CATH is an antibacterial peptide of frog origin. Nv-CATH has broad-spectrum antibacterial activity against gram-positive and gram-negative bacteria. Nv-CATH significantly protects mice from fatal infections caused by Staphylococcus aureus. Nv-CATH protects mice from bacterial infection through antimicrobial immunoregulatory duality .
|
-
- HY-P3906
-
|
Fungal
Apoptosis
Phospholipase
Reactive Oxygen Species (ROS)
|
Infection
|
Melittin free acid is a basic 26-amino-acid polypeptide, the major active ingredient of honeybee venom. Melittin free acid is an activator of phospholipase A2 (PLA2). Melittin free acid has broad-spectrum antifungal activity with MIC values of 0.4-60 μM. Melittin free acid hinders fungal growth by inducing cell apoptosis, repressing (1,3)-β-D-glucan synthase and participating in other pathways .
|
-
- HY-P3459
-
|
Bacterial
|
Infection
|
Tet-213 is a antimicrobial peptide. Tet-213 has broad spectrum antibacterial activity. Tet-213 can promote infected wound repair .
|
-
- HY-P5601
-
|
Bacterial
Fungal
|
Infection
|
Thanatin is an inducible cationic antimicrobial peptide. Thanatin is a pathogen-inducible single-disulfide-bond-containing β-hairpin AMP. Thanatin displays broad-spectrum activity against both Gram-negative and Gram-positive bacteria as well as against various species of fungi with MICs of 0.3-40 µM, 0.6-40 µM and 0.6-20 µM, respectively. Thanatin has the property of competitive replacement of divalent cations from bacterial outer membrane (OM), leading to OM disruption .
|
-
- HY-P3459A
-
|
Bacterial
|
Infection
|
Tet-213 TFA is a antimicrobial peptide. Tet-213 TFA has broad spectrum antibacterial activity. Tet-213 TFA can promote infected wound repair .
|
-
- HY-P5601A
-
|
Bacterial
Fungal
|
Infection
|
Thanatin TFA is an inducible cationic antimicrobial peptide. Thanatin TFA s a pathogen-inducible single-disulfide-bond-containing β-hairpin AMP. Thanatin TFA displays broad-spectrum activity against both Gram-negative and Gram-positive bacteria as well as against various species of fungi with MICs of 0.3-40 µM, 0.6-40 µM and 0.6-20 µM, respectively. Thanatin TFA has the property of competitive replacement of divalent cations from bacterial outer membrane (OM), leading to OM disruption .
|
-
- HY-P3914
-
Oct-CA(1-7)M(2-9)
|
Bacterial
|
Infection
|
Cecropin A (1-7)-Melittin A (2-9) is an antimicrobial peptide with antimicrobial activity against a broad spectrum of Gram-positive and Gram-negative aerobic bacteria, as well as antimalarial activity, without the adverse hemolytic properties of bee venom peptides .
|
-
- HY-P10219
-
|
Bacterial
|
Infection
Inflammation/Immunology
|
Brevicidine analog 22 (22) exerts broad spectrum antimicrobial activity and excellent stability (t1/2 = 40.98 h), with MICs of 2-16 μM for gram-negative and gram-positive bacteria .
|
-
- HY-P5552
-
|
Bacterial
Parasite
Fungal
|
Infection
|
Melimine is a hybrid antimicrobial peptide of Melittin (HY-P0233) and Protamine. Melimine is active against P. aeruginosa and S. aureus. Melimine has broad spectrum activity against bacteria, fungi and protozoa .
|
-
- HY-164388
-
|
Caspase
Apoptosis
Autophagy
Necroptosis
|
Cardiovascular Disease
Cancer
|
Z-VAD is an irreversible, broad-spectrum pan-caspase inhibitor that can inhibit a variety of caspases including caspase-3, -6, -7, -8, -9, etc. (with a weaker inhibitory effect on caspase-2). Z-VAD can block apoptosis signaling pathways, induce autophagy and necrosis in tumor cells, and has anti-angiogenic activity. Z-VAD can enhance the sensitivity of breast cancer and lung cancer cells to radiotherapy in vitro and in vivo, and prolong the growth delay of tumor xenograft models. Z-VAD is well tolerated and is mainly used in research related to cancer radiosensitization and cell death pathway regulation .
|
-
- HY-P3492
-
|
SARS-CoV
|
Infection
|
SARS-CoV-2-IN-34 (S-20-1) is a blood brain barrier penetrable pan-coronavirus (CoV) fusion inhibitor with broad-spectrum inhibitory activity. SARS-CoV-2-IN-34 effectively inhibits infection by pseudotyped and authentic SARS-CoV-2, and pseudotyped variants of concern (VOCs). SARS-CoV-2-IN-34 shows high affinity to RBD in S1 and HR1 domain in S2 of SARS-CoV-2 S protein. SARS-CoV-2-IN-34 can be used for the research of infection .
|
-
- HY-P1630
-
|
Bacterial
|
Infection
|
Buforin II, derived from buforin I, a protein isolated from the stomach of the Asian toad Bufo bufo gargarizans, is a potent antimicrobial peptide. Buforin II has antimicrobial activity against a broad spectrum of Gram-positive and Gram-negative bacteria .
|
-
- HY-P1222
-
|
Bacterial
|
Infection
|
LL-37, human is a 37-residue, amphipathic, cathelicidin-derived antimicrobial peptide, which exhibits a broad spectrum of antimicrobial activity. LL-37, human could help protect the cornea from infection and modulates wound healing .
|
-
- HY-P1222B
-
|
Bacterial
|
Infection
Inflammation/Immunology
|
LL-37, human acetate is a 37-residue, amphipathic, cathelicidin-derived antimicrobial peptide, which exhibits a broad spectrum of antimicrobial activity. LL-37, human acetate could help protect the cornea from infection and modulates wound healing .
|
-
- HY-P1222A
-
|
Bacterial
|
Infection
|
LL-37, human TFA is a 37-residue, amphipathic, cathelicidin-derived antimicrobial peptide, which exhibits a broad spectrum of antimicrobial activity. LL-37, human TFA could help protect the cornea from infection and modulates wound healing .
|
-
- HY-106228
-
|
Fungal
Bacterial
Glutathione Peroxidase
|
Infection
|
HLF1-11, a human lactoferrin-derived peptide, is a broad spectrum antimicrobial agent. HLF1-11 inhibits human MPO activity. HLF1-11 also directs GM-CSF-driven monocyte differentiation toward macrophages, and enhances immune responses .
|
-
- HY-P10975
-
|
SARS-CoV
Influenza Virus
Enterovirus
|
Infection
|
P9R is an antiviral peptide. P9R has broad-spectrum antiviral activities against the coronaviruses (SARS-CoV-2, MERS-CoV and SARS-CoV), A(H1N1)pdm09, A(H7N9) virus, and rhinovirus. P9R directly binds to viruses and inhibits virus-host endosomal acidification. P9R significantly protects mice from A(H1N1)pdm09 infection without generating drug-resistant virus. P9R can be used for pH-dependent respiratory viruses research .
|
-
- HY-P3350
-
|
Bacterial
|
Infection
|
LS-BF1 is a stable and low toxic cationic antimicrobial peptide. LS-BF1 displays broad spectrum of antibacterial activity, including the challenging ESKAPE pathogens, by cell membrane disruptive mechanism. LS-BF1 shows good in vivo efficacy for elimination of bacteria in a mouse infection model[1].
|
-
- HY-P1629
-
|
Bacterial
Fungal
Antibiotic
|
Infection
|
Temporin A is a short alpha-helical antimicrobial peptide isolated from the skin of the frog Rana temporaria. Temporin A is effective against a broad spectrum of Gram-positive bacteria. Temporin A interacts directly with the cell membrane of the microorganism and it is non-toxic to erythrocytes at concentrations that are antimicrobial. Temporin A also has antifungal activities (against yeast-like Candida albicans) .
|
-
- HY-P11012
-
|
SARS-CoV
|
Infection
|
EK1 is a peptide-based fusion inhibitor of coronaviruses (CoVs) with broad spectrum inhibition to a number of CoV species. EK1 shows substantially improved pan-CoV fusion inhibitory activity. EK1 potently inhibits SARS-CoV-2. EK1 can form a stable six-helix bundle (6HB) structure with both short α-hCoV and long β-hCoV N-terminal heptad repeats .
|
-
- HY-P5057B
-
|
Fluorescent Dye
Bacterial
|
Infection
|
5-FAM-Ahx-LL-37 TFA is a 5-FAM (HY-66022) labeled LL-37, human (HY-P1222). The carboxyfluorescein group is attached via a 6-carbon spacer, 6-Aminohexanoic acid (Ahx, HY-B0236). LL-37, human is a 37-residue, amphipathic, cathelicidin-derived antimicrobial peptide, which exhibits a broad spectrum of antimicrobial activity .
|
Cat. No. |
Product Name |
Target |
Research Area |
-
- HY-P99490
-
hzVSF-v13
|
Interleukin Related
SARS-CoV
|
Infection
Inflammation/Immunology
|
Burfiralimab (hzVSF-v13) is a monoclonal IgG4 antibody against vimentin expressed on the surface of virus-infected cells, with broad-spectrum antiviral activity and anti-inflammatory effects against virus-induced inflammation. Burfiralimab can be used in severe COVID-19 studies .
|
-
- HY-P99189
-
IMC-A12; NSC742460
|
IGF-1R
|
Cancer
|
Cixutumumab (IMC-A12) is a human anti-IGF-1R monoclonal antibody with high affinity that inhibits ligand-dependent receptor activation and downstream signaling. Cixutumumab also mediates the internalization and degradation of IGF-IR. Cixutumumab shows broad-spectrum anti-tumour activity and can be used in studies of cancers such as lung cancer, malignancies, leukaemia, non-small cell lung cancer and prostate cancer .
|
-
- HY-P991608
-
7F11C7
|
Mucin
|
Cancer
|
CTM01 is a murine IgG1 (or humanized IgG4) monoclonal antibody inhibitor targeting MUC1. CTM01 has a broad spectrum anticancer activity against solid tumors of epithelial origin, such as breast, lung and ovarian cancer .
|
Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
- HY-N14984
-
-
- HY-76200R
-
UK-109496 (Standard)
|
Microorganisms
Source classification
|
Reference Standards
Fungal
Bacterial
|
Voriconazole (Standard) is the analytical standard of Voriconazole. This product is intended for research and analytical applications. Voriconazole (UK-109496) is a second-generation, broad-spectrum triazole antifungal agent that inhibits fungal ergosterol biosynthesis. Voriconazole exerts its antifungal activity by inhibition of 14-α-lanosterol demethylation, which is mediated by fungal cytochrome P450 enzymes .
|
-
- HY-N15091
-
-
- HY-N14308
-
-
- HY-N7224
-
SF-1854
|
Structural Classification
Microorganisms
Ketones, Aldehydes, Acids
Source classification
|
Bacterial
Antibiotic
|
N-Formylfortimicin A (SF-1854) is an aminoglycoside antibiotic with broad-spectrum antibacterial activity. It primarily acts on bacterial ribosomes to inhibit protein synthesis and exhibits notable inhibitory effects against various Gram-positive and Gram-negative bacteria (e.g., E. coli with a MIC of 12.5-50 μg/mL), making it a potential candidate for research on bacterial infection-related diseases .
|
-
- HY-N0275
-
-
- HY-N14187
-
-
- HY-B0863
-
|
Source classification
|
Apoptosis
Autophagy
Necroptosis
|
Glyphosate, a non-selective systemic biocide with broad-spectrum activity, is an herbicidal derivative of the amino acid glycine. Glyphosate inhibits the enzymatic activity of the 5-endopyruvylshikimate 3-phosphate synthase (EPSPS) in the shikimic acid pathway, preventing the synthesis of the aromatic amino acids tyrosine, phenylalanine, and tryptophan. Glyphosate induces oxidative stress, neuroinflammation, and mitochondrial dysfunction, processes that lead to neuronal death by autophagia, necrosis, or apoptosis, as well as the appearance of behavioral and motor disorders .
|
-
- HY-B0778R
-
|
Structural Classification
Natural Products
Microorganisms
Source classification
|
Reference Standards
Antibiotic
Parasite
|
Milbemycin oxime (Standard) is the analytical standard of Milbemycin oxime. This product is intended for research and analytical applications. Milbemycin oxime is an orally active macrolide with broad-spectrum antiparasitic activity. Milbemycin oxime is a mixture of oximes consisting of oxime derivatives corresponding to milbemycin A4 and A3. Milbemycin oxime binds to glutamate-gated chloride channels and has inhibitory potency against intestinal nematodes and lung/heart worms .
|
-
- HY-N1950
-
-
- HY-N13961
-
-
- HY-N13964
-
-
- HY-N13986
-
-
- HY-N13959
-
-
- HY-133704
-
-
- HY-114551
-
-
- HY-B0239
-
-
- HY-N14491
-
-
- HY-126604
-
-
- HY-N14490
-
-
- HY-B1802A
-
-
- HY-N0168
-
-
- HY-N6705
-
-
- HY-122448A
-
-
- HY-N0275R
-
-
- HY-B0239R
-
-
- HY-N0168A
-
-
- HY-117108
-
-
- HY-N1950R
-
-
- HY-B0226
-
Nitrofural
|
Source classification
|
Bacterial
Antibiotic
|
Nitrofurazone (Nitrofural) is a broad spectrum antibiotic that has oral activity. Nitrofurazone is a nitro-aromatic drug. Nitrofurazone is active against both Gram-positive and Gram-negative bacteria .
|
-
- HY-N6735
-
-
- HY-17560
-
-
- HY-126637
-
|
Structural Classification
Microorganisms
Antibiotics
Source classification
Other Antibiotics
|
Bacterial
Fungal
|
Marasmic acid is a sesquiterpenoid with unsaturated dialdehyde functionality, first isolated from the Basidiomycete Marasmus conigenus. Marasmic acid has antibacterial, antifungal, cytotoxic and mutagenic activities, and its broad-spectrum activity is related to the α,β-unsaturated aldehyde group. However, its detailed biological mechanism of action has not been clarified. Previous studies have suggested that marasmic acid may exert its effects by reacting with endogenous nucleophiles or forming pyrrole derivatives. This study found that marasmic acid interferes with the membrane sensor histidine kinase MoSln1p of M. oryzae, superactivates the HOG pathway and causes cell death, indicating that its mechanism of action is different from other unsaturated dialdehyde sesquiterpenoids.
|
-
- HY-B1802AR
-
-
- HY-N1750R
-
-
- HY-N0168AR
-
-
- HY-N2478
-
-
- HY-B0226R
-
Nitrofural (Standard)
|
Microorganisms
Source classification
|
Reference Standards
Bacterial
Antibiotic
|
Nitrofurazone (Standard) is the analytical standard of Nitrofurazone. This product is intended for research and analytical applications. Nitrofurazone (Nitrofural) is a broad spectrum antibiotic that has oral activity. Nitrofurazone is a nitro-aromatic drug. Nitrofurazone is active against both Gram-positive and Gram-negative bacteria .
|
-
- HY-15310
-
-
- HY-17560R
-
|
Quinones
Microorganisms
Anthraquinones
Source classification
|
Reference Standards
Antibiotic
Bacterial
|
Demeclocycline hydrochloride (Standard) is the analytical standard of Demeclocycline hydrochloride (HY-17560). This product is intended for research and analytical applications. Demeclocycline hydrochloride is an orally active tetracycline antibiotic that inhibits the binding of aminoacyl tRNA by binding to the 30S ribosomal subunit, thereby affecting protein synthesis. Demeclocycline hydrochloride exhibits antibacterial activity against a broad spectrum of bacterial infections .
|
-
- HY-B0220
-
-
- HY-N2478R
-
-
- HY-B0220D
-
-
- HY-B0220R
-
-
- HY-B0147
-
Pefloxacinium
|
Infection
Classification of Application Fields
Disease Research Fields
|
Antibiotic
Bacterial
Parasite
DNA/RNA Synthesis
Topoisomerase
|
Pefloxacin is a broad spectrum antibiotic. Pefloxacin blocks DNA replication by inhibiting DNA gyrase. Pefloxacin inhibits DNA relaxation catalyzed by topoisomerase I with an IC50 of 45 μg/mL. Pefloxacin exhibits antibacterial activity against Escherichia coli, Pseudomonas aeruginosa, and Bacteroides fragilis with MIC90s of 0.12, 4, and 16 mg/L, respectively. Pefloxacin has anti-Plasmodium yoelii infection activity. Pefloxacin increase UVA-induced edema and immunesuppression. Pefloxacin can be used for infection studies .
|
-
- HY-B0220DR
-
-
- HY-Y0136
-
-
- HY-Y0136R
-
|
Structural Classification
Natural Products
Microorganisms
Source classification
Endogenous metabolite
|
Reference Standards
Endogenous Metabolite
Influenza Virus
HSV
VSV
|
3-Indoleacetonitrile (Standard) is the analytical standard of 3-Indoleacetonitrile. This product is intended for research and analytical applications. 3-Indoleacetonitrile is an indole derivative with anti-influenza activity. 3-Indoleacetonitrile is a plant hormone produced by cruxiferous vegetables. 3-Indoleacetonitrile exerts profound antiviral activity against a broad spectrum of influenza A viruses, HSV-1 and VSV viruses in vitro. 3-Indoleacetonitrile diminishes lung virus titers and alleviates lung lesions in vivo. 3-Indoleacetonitrile induces an increase in mitochondrial antiviral-signaling (MAVS) protein levels. 3-Indoleacetonitrile can be used in research for combating viral infections including COVID-19, HSV-1, and VSV .
|
-
- HY-12361
-
-
- HY-12361R
-
|
Structural Classification
Natural Products
Microorganisms
Source classification
|
Reference Standards
Parasite
|
PF 1022A (Standard) is the analytical standard of PF 1022A. This product is intended for research and analytical applications. PF 1022A is a cyclooctadepsipeptide with broadspectrum anthelmintic properties produced by fermentation of the fungus Mycelia sterilia. PF 1022A is a channel-forming ionophore. PF 1022A showes strong anthelmintic activities against Ascaridia galli in chickens. PF 1022A also can be used for angiostrongyliasis research[1][2][3].
|
-
Cat. No. |
Product Name |
Chemical Structure |
-
- HY-17373S
-
|
Posaconazole-d5 is a deuterium-labeled form of Posaconazole. Posaconazole is a broad-spectrum, second generation, triazole compound with antifungal activity .
|
-
-
- HY-17373S1
-
|
Posaconazole-d4 is a deuterium-labeled form of Posaconazole. Posaconazole is a broad-spectrum, second generation, triazole compound with antifungal activity .
|
-
-
- HY-14814S
-
|
Delafloxacin-d5 is deuterium labeled Delafloxacin. Delafloxacin (RX-3341; WQ-3034; ABT492) is a broad-spectrum fluoroquinolone antibiotic. Delafloxacin has a broad spectrum of activity that includes drug-resistant Staphylococcus aureus, Streptococcus pneumoniae, and Klebsiella pneumonia .
|
-
-
- HY-A0107S
-
|
Tetracycline-d6 is the deuterium labeled Tetracycline. Tetracycline is a broad-spectrum antibiotic, exhibiting activity against a wide range of gram-positive and gram-negative bacteria.
|
-
-
- HY-115364S
-
|
Parbendazole-d3 is the deuterium labeled Parbendazole. Parbendazole is a potent inhibitor of microtubule assembly, destabilizes tubulin, with an EC50 of 530 nM, and exhibits a broad-spectrum anthelmintic activity.
|
-
-
- HY-17373S3
-
|
Posaconazole-d7 (SCH 56592-d7) is deuterium labeled Posaconazole. Posaconazole is a broad-spectrum, second generation, triazole compound with antifungal activity.
|
-
-
- HY-17373S2
-
|
Posaconazole-d3 (SCH 56592-d3) is deuterium labeled Posaconazole. Posaconazole is a broad-spectrum, second generation, triazole compound with antifungal activity.
|
-
-
- HY-N0168S
-
|
Hesperetin-d3 is the deuterium labeled Hesperetin . Hesperetin is a natural flavanone, and acts as a potent and broad-spectrum inhibitor against human UGT activity. Hesperetin regulates apoptosis .
|
-
-
- HY-W015026S
-
|
Isobutylparaben-d4 is the deuterium labeled Isobutylparaben. Isobutylparaben (Isobutyl 4-hydroxybenzoate) is the agonist for PXR, CAR and PPAR. Isobutylparaben has a broad-spectrum antimicrobial activity and widely used in personal care products and cosmetics .
|
-
-
- HY-N0565AS
-
|
Doxycycline-d3 hydrochloride is deuterium labeled Doxycycline (hydrochloride). Doxycycline hydrochloride, an antibiotic, is an orally active and broad-spectrum metalloproteinase (MMP) inhibitor . Doxycycline hydrochloride shows antibacterial activity and anti-cancer cell proliferation activity .
|
-
-
- HY-B0455S
-
|
Lomefloxacin-d5 (hydrochloride) is the deuterium labeled Lomefloxacin hydrochloride. Lomefloxacin (SC47111A) hydrochloride is a broad-spectrum quinolone antibiotic, with antimicrobial activity. Lomefloxacin hydrochloride is used for the research of respiratory tract infections, genitourinary infections, gastrointestinal infections, ENT infections, etc. .
|
-
-
- HY-N0168AS
-
|
(Rac)-Hesperetin-d3 is the deuterium labeled (Rac)-Hesperetin. (Rac)-Hesperetin is the racemate of Hesperetin. Hesperetin is a natural flavanone, and acts as a potent and broad-spectrum inhibitor against human UGT activity. Hesperetin induces apoptosis via p38 MAPK activation.
|
-
-
- HY-A0294S
-
|
Ertapenem-d4 (MK-0826-d4) is deuterium labeled Ertapenem. Ertapenem (MK-0826) is a broad spectrum and long acting β-lactam antibiotic. Ertapenem has a broad-spectrum anti-anaerobic activity against a variety of anaerobes with a mode MIC of 0.12 μg/mL. Ertapenem can be used for the research of severe infections caused by bacteria in the skin, lungs, stomach, pelvis, and urinary tract .
|
-
-
- HY-N0565S3
-
|
Doxycycline- 13C,d3 is 13C and deuterium labeled Doxycycline. Doxycycline, an antibiotic, is an orally active and broad-spectrum metalloproteinase (MMP) inhibitor . Doxycycline shows antibacterial activity and anti-cancer cell proliferation activity .
|
-
-
- HY-A0088S
-
|
Cefotaxime-d3 (sodium) is the deuterium labeled Cefotaxime (sodium salt). Cefotaxime sodium salt, a β-lactamase stable cephalosporin and a third-generation cephalosporin antibiotic, possesses broad-spectrum antibiotic activity against numerous Gram-positive and Gram-negative bacteria .
|
-
-
- HY-12643S
-
|
Eprinomectin-d3 (MK-397-d3) is the deuterium-labeled Eprinomectin (HY-12643). Eprinomectin is a type of avermectin. Eprinomectin,as a broad-spectrum fungicide,has insecticidal,insecticidal and acaricidal activities. Eprinomectin induces apoptosis and autophagy in prostate cancer cells and has antitumor activity .
|
-
-
- HY-A0107S2
-
|
Tetracycline-d6-1 is deuterated labeled Tetracycline (HY-A0107). Tetracycline is a broad-spectrum antibiotic with oral activity. Tetracycline exhibits activity against a wide range of bacteria including gram-positive, gram-negative bacteria, chlamydiae, mycoplasmas and rickettsiae. Tetracycline can be used for the research of infections .
|
-
-
- HY-N0168AS1
-
|
(Rac)-Hesperetin- 13C,d3 is the 13C- and deuterium labeled (Rac)-Hesperetin. (Rac)-Hesperetin is the racemate of Hesperetin. Hesperetin is a natural flavanone, and acts as a potent and broad-spectrum inhibitor against human UGT activity. Hesperetin induces apoptosis via p38 MAPK activation.
|
-
-
- HY-B0239S3
-
|
Chloramphenicol-d4 is deuterium labeled Chloramphenicol. Chloramphenicol, a broad-spectrum antibiotic, acts as a potent inhibitor of bacterial protein biosynthesis . Chloramphenicol acts primarily on the 50S subunit of bacterial 70S rihosomes and inhibits peptide bond formation by suppressing peptidyl transferase activity .
|
-
-
- HY-W654101
-
|
Cefotaxime-d3 is the deuterium labeled Cefotaxime (HY-A0088A). Cefotaxime is the β-lactamase stable cephalosporin and the third-generation cephalosporin antibiotic. Cefotaxime possesses broad-spectrum antibiotic activity against numerous Gram-positive and Gram-negative bacteria .
|
-
-
- HY-B0458AS
-
|
Cefprozil-d4 is the deuterium labeled Cefprozi (HY-B0458A) . Cefprozil is a second-generation cephalosporin type antibiotic. Cefprozil exhibits broad-spectrum antibacterial activity, and is orally active. Cefprozil can be used for the study of pharyngitis, tonsillitis, otitis media, and uncomplicated skin infections .
|
-
-
- HY-14283S1
-
|
Luliconazole-d3 (NND 502-d3) is deuterium labeled Luliconazole. Luliconazole (NND 502)?is a topical antifungal imidazole antibiotic with broad-spectrum and potent antifungal activity. Luliconazole can be used for the research of skin infection, including?dermatophytosis, tinea corporis, tinea pedis?et al .
|
-
-
- HY-14283S
-
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Luliconazole- 13C7 (NND 502- 13C7) is 13C labeled Luliconazole. Luliconazole (NND 502)?is a topical antifungal imidazole antibiotic with broad-spectrum and potent antifungal activity. Luliconazole can be used for the research of skin infection, including?dermatophytosis, tinea corporis, tinea pedis?et al .
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- HY-76200S
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Voriconazole-d3 is the deuterium labeled Voriconazole. Voriconazole (UK-109496) is a second-generation, broad-spectrum triazole antifungal agent that inhibits fungal ergosterol biosynthesis. Voriconazole exerts its antifungal activity by inhibition of 14-α-lanosterol demethylation, which is mediated by fungal cytochrome P450 enzymes .
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- HY-14904AS
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Umifenovir-d6 (hydrochloride) is the deuterium labeled Umifenovir hydrochloride. Umifenovir hydrochloride is a potent, orally active broad-spectrum antiviral with activity against a number of enveloped and non-enveloped viruses. Umifenovir hydrochloride is used as an anti-influenza virus agent. Umifenovir hydrochloride could effectively inhibit the fusion of virus with host cells . Umifenovir hydrochloride is an efficient inhibitor of SARS-CoV-2 in vitro. Anti-inflammatory activity .
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- HY-W770956
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Cefotiam- 13C, 15N2 (SCE-963- 13C, 15N2) is the 13C- and 15N-labeled Cefotiam (HY-B0734). Cefotiam (SCE-963) is a parenteral cephalosporin antibiotic. Cefotiam has broad-spectrum activity against Gram-positive and Gram-negative bacteria .
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- HY-14956S
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Nemonoxacin-d3 is the deuterium labeled Nemonoxacin. Nemonoxacin (TG-873870) is an orally active and potent broad-spectrum antibiotic. Nemonoxacin shows good inhibitory activity against different species of staphylococci, streptococci, and enterococci, Neisseria gonorrhoeae, and Haemophilus influenza. Nemonoxacin can be used in the study of bacterial infections and community-acquired pneumonia .
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- HY-14956S1
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Nemonoxacin-d3-1 is the deuterium labeled Nemonoxacin. Nemonoxacin (TG-873870) is an orally active and potent broad-spectrum antibiotic. Nemonoxacin shows good inhibitory activity against different species of staphylococci, streptococci, and enterococci, Neisseria gonorrhoeae, and Haemophilus influenza. Nemonoxacin can be used in the study of bacterial infections and community-acquired pneumonia .
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- HY-14956S2
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Nemonoxacin-d4 is the deuterium labeled Nemonoxacin. Nemonoxacin (TG-873870) is an orally active and potent broad-spectrum antibiotic. Nemonoxacin shows good inhibitory activity against different species of staphylococci, streptococci, and enterococci, Neisseria gonorrhoeae, and Haemophilus influenza. Nemonoxacin can be used in the study of bacterial infections and community-acquired pneumonia .
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- HY-13678S
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Meropenem-d6 is the deuterium labeled Meropenem. Meropenem (SM 7338) is a carbapenem antibiotic with broad-spectrum antibacterial activity. Meropenem has activity against susceptible and resistant N. gonorrhoeae (MIC value of 0.02-0.06 mg/mL), H. influenzae (MIC value of 0.03-0.12 mg/mL), and H. ducreyi (MIC value of 0.015-0.12 mg/mL) .
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- HY-B0122S1
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Topiramate- 13C (McN 4853- 13C) is 13C labeled Topiramate. Topiramate (McN 4853) is a broad-spectrum antiepileptic agent. Topiramate is a GluR5 receptor antagonist. Topiramate produces its antiepileptic effects through enhancement of GABAergic activity, inhibition of kainate/AMPA receptors, inhibition of voltage-sensitive sodium and calcium channels, increases in potassium conductance, and inhibition of carbonic anhydrase .
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- HY-B0330DS
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(R)-Ofloxacin-d3 is the deuterium labeled (R)-Ofloxacin. (R)-Ofloxacin is the dextrorotatory enantiomer of Ofloxacin (HY-B0125) and is an orally effective fluoroquinolone antibiotic. (R)-Ofloxacin can inhibit the activity of bacterial DNA topoisomerase II, interfere with bacterial DNA replication and repair, and exert a bactericidal effect. (R)-Ofloxacin has a broad-spectrum antibacterial activity and has inhibitory effects on both Gram-negative and Gram-positive bacteria .
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- HY-13678S1
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Meropenem-d6-1 (SM 7338-d6-1) is the deuterium labeled Meropenem. Meropenem (SM 7338) is a carbapenem antibiotic with broad-spectrum antibacterial activity. Meropenem has activity against susceptible and resistant N. gonorrhoeae (MIC value of 0.02-0.06 mg/mL), H. influenzae (MIC value of 0.03-0.12 mg/mL), and H. ducreyi (MIC value of 0.015-0.12 mg/mL) .
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- HY-116214S
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Cyprodinil-d5(CGA-219417-d5) is the deuterium labeled Cyprodinil (HY-116214). Cyprodinil (CGA-219417) is a broad-spectrum anilinopyrimidine fungicide and an activator of the aryl hydrocarbon receptor. Cyprodinil also has anti-androgenic and androgenic activities. Cyprodinil can inhibit the biosynthesis of methionine in plant-pathogenic fungi and protect fruits and vegetables from a variety of pathogens .
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- HY-B0210S
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Cefoperazone-d5 is deuterium labeled Cefoperazone. Cefoperazone, a semisynthetic cephalosporin, has a broad spectrum of antibacterial activity .
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- HY-116214S1
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Cyprodinil- 13C6 (CGA-219417- 13C6) is the 13C6 labeled Cyprodinil (HY-116214). Cyprodinil (CGA-219417) is a broad-spectrum anilinopyrimidine fungicide and an activator of the aryl hydrocarbon receptor. Cyprodinil also has anti-androgenic and androgenic activities. Cyprodinil can inhibit the biosynthesis of methionine in plant-pathogenic fungi and protect fruits and vegetables from a variety of pathogens .
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- HY-B1075AS
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(Rac)-Fosfomycin (benzylamine)- 13C3 is the 13C labeled Fosfomycin . Fosfomycin (MK-0955) is a broad-spectrum antibiotic. Fosfomycin can cross blood-brain barrier penetrating, and irreversibly inhibits an early stage in cell wall synthesis. Fosfomycin shows anti-bacteria activity for a range of bacteria, including multidrug-resistant (MDR), extensively drug-resistant (XDR), and pan-drug-resistant (PDR) bacteria .
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- HY-10581AS
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Gatifloxacin-d3 (hydrochloride) is the deuterium labeled Gatifloxacin (hydrochloride). Gatifloxacin hydrochloride (AM-1155; BMS-206584; PD135432) is a potent fluoroquinolone antibiotic with broad-spectrum antibacterial activity. Gatifloxacin hydrochloride inhibits bacterial type II topoisomerases (IC50=13.8 μg/ml for S. aureus topoisomerase IV) and E. coli DNA gyrase (IC50 = 0.109 μg/ml). Gatifloxacin hydrochloride can be used to treat bacterial conjunctivitis in vivo.
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- HY-B0467AS
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Amoxicillin- 13C6 is the 13C6 labeled Amoxicillin. Amoxicillin is an antibiotic with good oral absorption and broad spectrum antimicrobial activity.
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- HY-B0467S
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Amoxicillin-d4 is a deuterium labeled Amoxicillin. Amoxicillin is an antibiotic with good oral absorption and broad spectrum antimicrobial activity .
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- HY-W747676
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Glyphosate- 13C is the 13C-labeled Glyphosate (HY-B0863). Glyphosate, a non-selective systemic biocide with broad-spectrum activity, is an herbicidal derivative of the amino acid glycine. Glyphosate inhibits the enzymatic activity of the 5-endopyruvylshikimate 3-phosphate synthase (EPSPS) in the shikimic acid pathway, preventing the synthesis of the aromatic amino acids tyrosine, phenylalanine, and tryptophan. Glyphosate induces oxidative stress, neuroinflammation, and mitochondrial dysfunction, processes that lead to neuronal death by autophagia, necrosis, or apoptosis, as well as the appearance of behavioral and motor disorders .
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- HY-B0122S
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Topiramate-13C6 (McN 4853-13C6) is the 13C labeled isotope of Topiramate (HY-B0122). Topiramate (McN 4853) is a broad-spectrum antiepileptic agent. Topiramate is a GluR5 receptor antagonist. Topiramate produces its antiepileptic effects through enhancement of GABAergic activity, inhibition of kainate/AMPA receptors, inhibition of voltage-sensitive sodium and calcium channels, increases in potassium conductance, and inhibition of carbonic anhydrase .
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- HY-B0272S2
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Rifampicin-d4 is the deuterium labeled Rifampicin. Rifampicin is a potent and broad spectrum antibiotic against bacterial pathogens. Rifampicin has anti-influenza virus activities.
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- HY-A0269S
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Mecillinam-d12 is deuterium labeled Mecillinam. Mecillinam (Amdinocillin), the β-lactam antibiotic, has a broad spectrum of activity against gram-negative organisms .
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- HY-B0272S
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Rifampicin-d3 is the deuterium labeled Rifampicin. Rifampicin is a potent and broad spectrum antibiotic against bacterial pathogens. Rifampicin has anti-influenza virus activities .
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- HY-B1190S
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Cefadroxil-d4 (hydrate) is the deuterium labeled Cefadroxil hydrate (HY-B1190A). Cefadroxil hydrate is an orally active broad-spectrum cephalosporin antibiotic. Cefadroxil hydrate inhibits bacterial cell wall synthesis and enhances the expression of glutamate transporter-1. Cefadroxil hydrate is dependent on the intestinal peptide transporter PepT1 for small intestinal absorption. Cefadroxil hydrate has inhibitory and bactericidal activity against a variety of Gram-positive and Gram-negative bacteria and has analgesic effects on neuropathic pain .
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- HY-W740028
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Cefditoren-d3 (sodium) (ME 1206-d3) is deuterium labeled Cefditoren (sodium). Cefditoren sodium (ME 1206) is a broad-spectrum, third-generation, oral cephalosporin antibacterial with enhanced stability against many common β lactamases. Cefditoren sodium has activity against Gram-negative organisms and Gram-positive organisms. Cefditoren sodium can be used in the research of infection diseases such as acute exacerbations of chronic bronchitis, community-acquired pneumonia (CAP), streptococcal pharyngitis/tonsillitis, or uncomplicated skin and skin structure infections .
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- HY-B0863S5
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Glyphosate- 13C, 15N-1 is the 13C- and 15N-labeled Glyphosate (HY-B0863). Glyphosate, a non-selective systemic biocide with broad-spectrum activity, is an herbicidal derivative of the amino acid glycine. Glyphosate inhibits the enzymatic activity of the 5-endopyruvylshikimate 3-phosphate synthase (EPSPS) in the shikimic acid pathway, preventing the synthesis of the aromatic amino acids tyrosine, phenylalanine, and tryptophan. Glyphosate induces oxidative stress, neuroinflammation, and mitochondrial dysfunction, processes that lead to neuronal death by autophagia, necrosis, or apoptosis, as well as the appearance of behavioral and motor disorders .
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- HY-174353S
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CYP51-IN-23-d3 is a potent and broad-spectrum CYP51 inhibitor with a MIC80 of 1 μg/mL against Aspergillus fumigatum . CYP51-IN-23-d3 can prevent fungal phase transformation and biofilm formation. CYP51-IN-23-d3 exhibits anti-drug resistance activity and fungal activity, and shows excellent safety for cells and significant pharmacological activity in mice. CYP51-IN-23-d3 can be used for the study of invasive fungal infections (IFIs) .
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- HY-123047S
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Tibolone-d5 is deuterium labeled Tibolone. Tibolone is a broad spectrum gonadal steroid agonist with progestagenic, androgenic, and estrogenic activities. Tibolone can be used for postmenopausal osteoporosis research .
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- HY-B0272S1
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Rifampicin-d8 (Rifampin-d8) is the deuterium labeled Rifampicin. Rifampicin is a potent and broad spectrum antibiotic against bacterial pathogens. Rifampicin has anti-influenza virus activities.
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- HY-B1145S
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Chlorhexidine-d8 (dihydrochloride) is the deuterium labeled Chlorhexidine dihydrochloride (HY-B1145). Chlorhexidine dihydrochloride is a orally active cationic antimicrobial agent that targets microbial cell membranes. Chlorhexidine dihydrochloride binds to cell membrane phospholipids non-specifically, destroys membrane structure and induces leakage of cell contents. Chlorhexidine dihydrochloride has broad-spectrum bactericidal activity against both Gram-positive and Gram-negative bacteria. Chlorhexidine dihydrochloride can interfere with membrane permeability, cause protein precipitation and energy metabolism disorders, such as rapid inhibition of microbial growth and induction of cell death (necrosis or apoptosis) .
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- HY-17452AS
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Cefditoren Pivoxil-d3 (Cefditoren pivoxyl-d3) is deuterium labeled Cefditoren Pivoxil. Cefditoren Pivoxil (ME 1207) is a broad-spectrum, third-generation, oral cephalosporin antibacterial with enhanced stability against many common β lactamases. Cefditoren Pivoxil has activity against Gram-negative organisms and Gram-positive organisms. Cefditoren Pivoxil can be used in the research of infection diseases such as acute exacerbations of chronic bronchitis, community-acquired pneumonia (CAP), streptococcal pharyngitis/tonsillitis, or uncomplicated skin and skin structure infections .
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- HY-B0223S4
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Albendazole-d3-1 (SKF-62979-d3-1) is the deuterium labeled Albendazole (HY-B0223). Albendazole (SKF-62979) is an orally active and broad-spectrum parasiticide with high effectiveness and low host toxicity, is used for the research of gastrointestinal parasites in humans and animals. Albendazole induces apoptosis and autophagy in cancer cells. Albendazole also inhibits tubulin polymerization and HIF-1α, VEGF expression, has antioxidant activity, and inhibits the glycolytic process in cancer cells .
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- HY-B0239S2
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Threo-Chloramphenicol-d6 is the deuterium labeled Chloramphenicol . Chloramphenicol is an orally active, potent and broad-spectrum antibiotic. Chloramphenicol shows antibacterial activity. Chloramphenicol represses the oxygen-labile transcription factor and hypoxia inducible factor-1 alpha (HIF-1α) in hypoxic A549 and H1299 cells. Chloramphenicol suppresses the mRNA levels of vascular endothelial growth factor (VEGF) and glucose transporter 1, eventually decreasing VEGF release. Chloramphenicol can be used for anaerobic infections and lung cancer research .
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- HY-B1282S
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Sulfaquinoxaline-d4 is the deuterium labeled Sulfaquinoxaline. Sulfaquinoxaline is an antimicrobial for veterinary use, with activity against a broad spectrum of Gram-negative and Gram-positive bacteria. Sulfaquinoxaline is used to prevent coccidiosis and bacterial infections .
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- HY-W698952S
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3β hydroxy Tibolone-d5 is deuterium labeled Tibolone. Tibolone is a broad spectrum gonadal steroid agonist with progestagenic, androgenic, and estrogenic activities. Tibolone can be used for postmenopausal osteoporosis research .
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- HY-B1190S2
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Cefadroxil- 13C6 (BL-S 578- 13C6) is 13C labeled Cefadroxil (HY-B1190). Cefadroxil is an orally active broad-spectrum cephalosporin antibiotic. Cefadroxil inhibits bacterial cell wall synthesis and enhances the expression of glutamate transporter-1. Cefadroxil is dependent on the intestinal peptide transporter PepT1 for small intestinal absorption. Cefadroxil has inhibitory and bactericidal activity against a variety of Gram-positive and Gram-negative bacteria and has analgesic effects on neuropathic pain .
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- HY-W738281
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Chlorhexidine-d8 is deuterium-labeled Chlorhexidine (HY-B1248) . Chlorhexidine is a orally active cationic antimicrobial agent that targets microbial cell membranes. Chlorhexidine binds to cell membrane phospholipids non-specifically, destroys membrane structure and induces leakage of cell contents. Chlorhexidine has broad-spectrum bactericidal activity against both Gram-positive and Gram-negative bacteria. Chlorhexidine can interfere with membrane permeability, cause protein precipitation and energy metabolism disorders, such as rapid inhibition of microbial growth and induction of cell death (necrosis or apoptosis) .
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- HY-B1256S
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Cefuroxime-d3 is deuterium labeled Cefuroxime (sodium). Cefuroxime sodium is an orally active second-generation cephalosporin antibiotic with increased stability to β-lactamase. Cefuroxime sodium has a broad spectrum activity against Gram-positive and Gram-negative bacteria .
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- HY-B1885S
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Fenitrothion-d6 is the deuterium labeled Fenitrothion (HY-B1885). Fenitrothion is a broad-spectrum and orally active insecticide/acaricide. Fenitrothion inhibits cholinesterase, AMPKα and IRS1/PI3K/AKT. Fenitrothion causes Apoptosis, reduces SOD activity. Fenitrothion shows insecticidal effect against Rhyzopertha dominica and Tribolium castaneum adults. Fenitrothion is widely used in cotton crops, vegetable crops, fruit crops and field crops, especially rice. Fenitrothion can be used for brain and spleen toxicology studies .
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- HY-B0506S1
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Nadifloxacin-d5 (OPC7251-d5) is deuterium labeled Nadifloxacin (HY-B0506). Nadifloxacin (OPC7251) is a broad-spectrum quinolone antibiotic. Nadifloxacin inhibits bacterial DNA gyrase and topoisomerase IV, interfering with DNA replication. It also suppresses the production of proinflammatory cytokines (such as IL-1α, IL-6, and IL-8). Nadifloxacin exhibits antibacterial activity against various pathogens, including Propionibacterium acnes and Staphylococcus aureus. Nadifloxacin also exhibits anti-inflammatory activity. Nadifloxacin can be used in the research of skin infections such as acne vulgaris, folliculitis, and impetigo .
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- HY-B0724BS
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Pazufloxacin-d4 is deuterium labeled Pazufloxacin (HY-B0724B). Pazufloxacin is an orally active fluoroquinolone antimicrobial agent. Pazufloxacin inhibits DNA gyrase with IC50 values of 0.88 μg/mL (E. coli) and 1.9 μg/mL (P. aeruginosa). Pazufloxacin exhibits broad-spectrum antimicrobial activity, with MIC90 values ranging from 0.025 to 100 μg/mL against Gram-positive and Gram-negative bacteria, non-fermenting bacteria, Legionella spp., and anaerobic bacteria. Pazufloxacin is indicated for research on systemic infections, lung infections, urinary tract infections, and Legionella pneumonia .
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- HY-B1923S
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Piperacillin-d5 is deuterium labeled Piperacillin. Piperacillin is kind of semisynthetic penicillins. Piperacillin has a broad spectrum of activity against Gram-positive and Gram-negative aerobic and anaerobic bacteria. Piperacillin has shown greater activity against β-lactamase-producing organisms than the other penicillins .
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- HY-B0272S3
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Rifampicin-d11 (Rifampin-d11; Rifamycin AMP-d11) is the deuterium labeled Rifampicin (HY-B0272) . Rifampicin is a potent and broad spectrum antibiotic against bacterial pathogens. Rifampicin has anti-influenza virus activities. Rifampicin shows anti-orthopoxvirus activity .
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- HY-B0434S1
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Ribavirin- 15N, d2 is 15N and deuterated labeled Ribavirin (HY-B0434). Ribavirin (ICN-1229) is an antiviral agent against a broad spectrum of viruses including HCV, HIVl, and RSV. Ribavirin also has anti-orthopoxvirus and anti-variola activities.
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- HY-W713297
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Moroxydine hydrochloride-d8 (ABOB hydrochloride-d8) is the deuterium labeled Moroxydine (ABOB) hydrochloride (HY-B0420A). Moroxydine hydrochloride is a broad-spectrum agent with multi-antiviral activities against DNA and RNA viruses, including influenza virus, herpes simplex, varicella zoster, measles, mumps disease, hepatitis C virus, etc. Moroxydine hydrochloride exhibits excellent antiviral activity and shows low cytotoxicity to cells infected by dsRNA viruses (grass carp reovirus, GCRV) and large DNA viruses (giant salamander iridovirus, GSIV). Moroxydine hydrochloride blocks the GCRV-induced cytopathic effects and eliminates nucleocapsids in ctenopharyngodon idella kidney (CIK) cells to keep the normal morphological structure. Moroxydine hydrochloride significantly inhibits the apoptosis, the caspase 3 activity, Bax expression and down-regulates Bcl-2 levels [1][2][3].
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- HY-B0126S
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Marbofloxacin-d8 is the deuterium labeled Marbofloxacin. Marbofloxacin is a third generation fluoroquinolone and orally active antimicrobial agent, which has a broad spectrum bactericidal activity and good efficacy. Marbofloxacin can be used for the research of infections by Gram-positive and Gram-negative bacteria and Mycoplasma .
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- HY-B0126AS
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Marbofloxacin-d8 (hydrochloride) is deuterium labeled Marbofloxacin (hydrochloride). Marbofloxacin hydrochloride is a third generation fluoroquinolone and orally active antimicrobial agent, which has a broad spectrum bactericidal activity and good efficacy. Marbofloxacin hydrochloride can be used for the research of infections by Gram-positive and Gram-negative bacteria and Mycoplasma .
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- HY-B0450S1
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Ciclopirox-d11 (sodium) is deuterium labeled Ciclopirox. Ciclopirox (HOE296b) is a synthetic antifungal agent that can be used for superficial mycoses reseaech. Ciclopirox olamine has a very broad spectrum of activity and inhibits dermatophytes, yeasts, molds, and many Gram-positive and Gram-negative species pathogenic .
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- HY-B0450S
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Ciclopirox-d11 is the deuterium labeled Ciclopirox. Ciclopirox (HOE296b) is a synthetic antifungal agent that can be used for superficial mycoses reseaech. Ciclopirox olamine has a very broad spectrum of activity and inhibits dermatophytes, yeasts, molds, and many Gram-positive and Gram-negative species pathogenic .
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- HY-108325S
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Brequinar-d3 (DUP785-d3) is deuterium labeled Brequinar. Brequinar (DUP785) is a potent inhibitor of dihydroorotate dehydrogenase (DHODH) with an IC50 of 5.2 nM for human DHODH. Brequinar has potent activities against a broad spectrum of viruses. Brequinar also has an anti-SARS2 activity .
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- HY-W779404
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Ribavirin- 13C2 (Ribasphere- 13C2) is the 13C-labeled Ribavirin (HY-B0434). Ribavirin (ICN-1229) is an antiviral agent against a broad spectrum of viruses including HCV, HIVl, and RSV. Ribavirin also has anti-orthopoxvirus and anti-variola activities.
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- HY-W011117S
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Danofloxacin-d3 is deuterium labeled Danofloxacin. Danofloxacin is a third generation fluoroquinolone and orally active antimicrobial agent. Danofloxacin shows a broad spectrum of activity against most Gram-negative and Gram-positive bacteria, mycoplasma and chlamydia species, and plays an antimicrobial role by inhibition of bacterial DNA-gyrase .
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- HY-W011117S1
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Danofloxacin-d3-1 is deuterium labeled Danofloxacin. Danofloxacin is a third generation fluoroquinolone and orally active antimicrobial agent. Danofloxacin shows a broad spectrum of activity against most Gram-negative and Gram-positive bacteria, mycoplasma and chlamydia species, and plays an antimicrobial role by inhibition of bacterial DNA-gyrase .
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- HY-B0220S
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Erythromycin-d6 is the deuterium labeled Erythromycin. Erythromycin is a macrolide antibiotic produced by actinomycete?Streptomyces erythreus?with a broad spectrum of antimicrobial activity. Erythromycin acts by binding to bacterial 50S ribosomal subunits and inhibits?RNA-dependent protein synthesis?by blockage of transpeptidation and/or translocation reactions, without affecting synthesis of nucleic acid .
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- HY-13685S1
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Miltefosine-d4 (HePC-d4) is deuterium labeled Miltefosine. Miltefosine is a broad spectrum antimicrobial, anti-leishmanial, phospholipid agent acting by inhibiting the PI3K/Akt activity . Miltefosine is an inhibitor of CTP-phosphocholine cytidyltransferase (CCT) .
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- HY-12651S
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Primaquine-d3 (diphosphate) is the deuterium labeled Primaquine diphosphate. Primaquine Diphosphate (Primaquine phosphate), an 8-aminoquinoline, exerts a broad spectrum of activities against various stages of parasitic malaria. Primaquine Diphosphate remains as the only agent that destroys late hepatic stages and latent tissue forms of Plasmodium vivax and Plasmodium ovale .
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- HY-13582S
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Carbendazim-d4 is the deuterium labeled Carbendazim. Carbendazim is a potent and orally active broad-spectrum?benzimidazole fungicide and can be acts as a pesticide for fungal diseases research, such as Seproria,?Fusarium?and?Sclerotina . Carbendazim is a benzimidazole (HY-Y1825) derivative with antitumor activity and used for cancer research, especially advanced solid tumors and lymphoma .
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- HY-B1805S
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Triclocarban-d4 is the deuterium labeled Triclocarban. Triclocarban (3,4,4′-Trichlorocarbanilide), a broad spectrum antibacterial compound, is widely used in a broad range of applications such as the production of soaps, skin creams, toothpastes and deodorants. Triclocarban is a potential endocrine-disrupting chemical with the capacity to modulate androgen and estrogen activities as well as other hormone-mediated biological processes .
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- HY-13582S1
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Carbendazimb-d3 is the deuterium labeled Carbendazimb (HY-13582). Carbendazim is a potent and orally active broad-spectrum?benzimidazole fungicide and can be acts as a pesticide for fungal diseases research, such as Seproria,?Fusarium?and?Sclerotina . Carbendazim is a benzimidazole (HY-Y1825) derivative with antitumor activity and used for cancer research, especially advanced solid tumors and lymphoma .
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- HY-B0220S1
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Erythromycin- 13C,d3 is the 13C- and deuterium labeled Erythromycin. Erythromycin is a macrolide antibiotic produced by actinomycete?Streptomyces erythreus?with a broad spectrum of antimicrobial activity. Erythromycin acts by binding to bacterial 50S ribosomal subunits and inhibits?RNA-dependent protein synthesis?by blockage of transpeptidation and/or translocation reactions, without affecting synthesis of nucleic acid .
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- HY-135853S
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Molnupiravir-d7 is the deuterium labeled Molnupiravir. Molnupiravir (EIDD-2801) is an orally bioavailable prodrug of the ribonucleoside analog EIDD-1931. Molnupiravir has broad spectrum antiviral activity against influenza virus and multiple coronaviruses, such as SARS-CoV-2, MERS-CoV, SARS-CoV. Molnupiravir has the potential for the research of COVID-19, and seasonal and pandemic influenza .
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- HY-W585956
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Triclocarban- 13C6 is the 13C labeled isotope of Triclocarban (HY-B1805). Triclocarban (3,4,4′-Trichlorocarbanilide), a broad spectrum antibacterial compound, is widely used in a broad range of applications such as the production of soaps, skin creams, toothpastes and deodorants. Triclocarban is a potential endocrine-disrupting chemical with the capacity to modulate androgen and estrogen activities as well as other hormone-mediated biological processes .
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- HY-N7101S1
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Cefpodoxime Proxetil-d6 (U-76,252-d6) is deuterium labeled Cefpodoxime Proxetil. Cefpodoxime proxetil is an orally administered broad spectrum third-generation cephalosporin. Cefpodoxime proxetil has anti-bacterial activity. Cefpodoxime proxetil binds to penicillin binding proteins (PBPs) which inhibits peptidoglycan synthesis, finally results in interfering bacterial cell wall biosynthesis .
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- HY-B0220S2
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Erythromycin-d3 is the deuterium labeled Erythromycin . Erythromycin is a macrolide antibiotic produced by actinomycete Streptomyces erythreus with a broad spectrum of antimicrobial activity. Erythromycin binds to bacterial 50S ribosomal subunits and inhibits RNA-dependent protein synthesis by blockage of transpeptidation and/or translocation reactions, without affecting synthesis of nucleic acid. Erythromycin also exhibits antitumor and neuroprotective effect in different fields of research .
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- HY-17508S1
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Clarithromycin-d3 is the deuterium labeled Clarithromycin (HY-17508) . Clarithromycin has a broad spectrum of antimicrobial activity. Clarithromycin inhibits the CYP3A4-catalyzed triazolam alpha-hydroxylation with the IC50 (Ki) value of 56 (43) μM . Clarithromycin significantly inhibits the HERG potassium current .Clarithromycin affects the autophagic flux by impairing the signaling pathway linking hERG1 and PI3K .
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- HY-B1805S1
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Triclocarban- 13C13 (3,4,4'-Trichlorocarbanilide- 13C13) is 13C labeled Triclocarban. Triclocarban (3,4,4′-Trichlorocarbanilide), a broad spectrum antibacterial compound, is widely used in a broad range of applications such as the production of soaps, skin creams, toothpastes and deodorants. Triclocarban is a potential endocrine-disrupting chemical with the capacity to modulate androgen and estrogen activities as well as other hormone-mediated biological processes .
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- HY-B0147S
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Pefloxacin-d5 is the deuterium labeled Pefloxacin (HY-B0147). Pefloxacin is a broad spectrum antibiotic. Pefloxacin blocks DNA replication by inhibiting DNA gyrase. Pefloxacin inhibits DNA relaxation catalyzed by topoisomerase I with an IC50 of 45 μg/mL. Pefloxacin exhibits antibacterial activity against Escherichia coli, Pseudomonas aeruginosa, and Bacteroides fragilis with MIC90s of 0.12, 4, and 16 mg/L, respectively. Pefloxacin has anti-Plasmodium yoelii infection activity. Pefloxacin increase UVA-induced edema and immunesuppression. Pefloxacin can be used for infection studies .
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- HY-W015490S
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1,4-Naphthoquinone-d6 is the deuterium labeled 1,4-Naphthoquinone. 1,4-Naphthoquinone is an inhibitor with broad-spectrum inhibitory activity targeting DNA polymerase, NF-κB and monoamine oxidase (MAO-A/B), with antibacterial and anti-biofilm efficacy. 1,4-Naphthoquinone is a competitive inhibitor of MAO-B (Ki=1.4 μM) and a non-competitive inhibitor of MAO-A (Ki=7.7 μM). 1,4-Naphthoquinone inhibits DNA polymerase pol α, β, γ, δ, ε, λ with IC50 ranging from 5.57-128 μM. 1,4-Naphthoquinone inhibits tumor cell proliferation, induces apoptosis and necrosis, and has anti-angiogenic and anti-inflammatory activities by inducing oxidative stress, depleting glutathione (GSH), inhibiting DNA polymerase-mediated DNA synthesis and blocking NF-κB nuclear translocation. 1,4-Naphthoquinone can be used in anti-bacterial , anti-tumor and anti-inflammatory studies, including inhibition of melanoma and colon cancer cell growth and endothelial cell function, as well as LPS-induced inflammation models .
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- HY-B0712S1
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Ceftriaxone- 13C2,d3 triethylammonium salt is 13C and deuterated labeled Ceftriaxone (HY-B0712). Ceftriaxone (Ro 13-9904 free acid) is a broad spectrum β-lactam third-generation cephalosporin antibiotic, which has good antibacterial activity against a variety of gram-negative and positive bacteria. Ceftriaxone is a covalent inhibitor of GSK3β with IC50 value of 0.78 mM. Ceftriaxone is an inhibitor of Aurora B. Ceftriaxone has anti-inflammatory, antitumor and antioxidant activities. Ceftriaxone can be used in the study of bacterial infections and meningitis .
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- HY-100427S
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Imazamox- 13C,d3 is the 13C- and deuterium labeled Imazamox. Imazamox (CL29926) is a systemic herbicide that inhibits the production of acetolactate synthase (ALS) in plants with high selectivity, high activity, safety and broadspectrum activity, which would then inhibit plant growth and ultimately lead to plant death .
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- HY-N7101S
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Cefpodoxime proxetil-d7 (U-76-d7,252-d7; CS-807-d7) is the deuterium labeled Cefpodoxime Proxetil (HY-N7101). Cefpodoxime Proxetil is an orally active broad spectrum third-generation cephalosporin with potent antibacterial activity against both Gram-positive and Gram-negative bacteria including staphylococci, streptococci, Haemophilus influenzae, Neisseria gonorrhoeae, Escherichia coli, Klebsiella pnuemoniae, Citrobacter spp, and Proteus spp. Cefpodoxime Proxetil binds to penicillin binding proteins (PBPs), which inhibits peptidoglycan synthesis, finally results in interfering bacterial cell wall biosynthesis. Cefpodoxime Proxetil can be used against skin structure infections, acute otitis media, pharyngitis, tonsillitis, upper respiratory tract infection, urinary tract infections and sexually transmitted diseases .
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- HY-169175
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Alkynes
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CN-CC-861 is a broad-spectrum antibiotic. CN-CC-861 shows antibiotic activities for susceptible and multidrug-resistant bacteria. CN-CC-861 shows potent bactericidal activity in vivo .
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