2. Anti-infection
  3. SARS-CoV Filovirus Hepatitis E Virus (HEV)
  4. SCR005

SCR005 is a synthetic carbohydrate receptor (SCR) with broad-spectrum antiviral activity. SCR005 inhibits the entry of enveloped viruses across multiple families (Coronaviridae: SARS-CoV-1, SARS-CoV-2, MERS-CoV; Filoviridae: EBOV, MARV; Paramyxoviridae: NiV, HeV) and the glycosylated nonenveloped rotavirus. SCR005 binds viral envelope N-glycans, blocking viral binding to host cells or both binding and membrane fusion. SCR005 exerts prophylactic effects in hACE2 mice infected with SARS-CoV-2. SCR005 can be used for the study and prevention of enveloped virus pandemics.

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SCR005

SCR005 Chemical Structure

CAS No. : 2409183-70-4

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SCR005 Related Antibodies

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Description

SCR005 is a synthetic carbohydrate receptor (SCR) with broad-spectrum antiviral activity. SCR005 inhibits the entry of enveloped viruses across multiple families (Coronaviridae: SARS-CoV-1, SARS-CoV-2, MERS-CoV; Filoviridae: EBOV, MARV; Paramyxoviridae: NiV, HeV) and the glycosylated nonenveloped rotavirus. SCR005 binds viral envelope N-glycans, blocking viral binding to host cells or both binding and membrane fusion. SCR005 exerts prophylactic effects in hACE2 mice infected with SARS-CoV-2. SCR005 can be used for the study and prevention of enveloped virus pandemics[1].

In Vitro

SCR005 (10 μM, 30 min) inhibits infection of VERO-TMPRSS2 cells by pseudotyped virus particles (PVPs) from SARS-CoV-1, SARS-CoV-2, MERS-CoV, NiV, HeV, and EBOV[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SCR005 Related Antibodies
In Vivo

SCR005 (3 mg/kg, i.n., single dose) improves survival rate in hACE2 mice infected SARS-CoV-2[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: hACE2 knock-in mice (4-5-month-old) were intranasally challenged with 2 × 103 PFU of SARS-CoV-1/2[1]
Dosage: 3 mg/kg
Administration: i.n., single dose
Result: Improved survival rate to 30%.
Decreased lung and brain viral RNA copies by multiple orders of magnitude.
Reduced perivascular infiltrates and necrotic neurons in lung and brain tissues.
Decreased pro-inflammatory cytokine levels in bronchoalveolar lavage fluid (BALF), with IL-18 and IFN-γ reduced.
Molecular Weight

578.71

Formula

C36H34N8
CAS No.
SMILES

C1(C/N=C/C2=CC=CN2)=CC(C3=CC(C/N=C/C4=CC=CN4)=CC(C/N=C/C5=CC=CN5)=C3)=CC(C/N=C/C6=CC=CN6)=C1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SCR005 Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SCR0052409183-70-4SCR 005SCR-005SARS-CoVFilovirusHepatitis E Virus (HEV)SARS coronavirusHepatitis E VirushACE2 miceSARS-CoV-2SARS-CoV-1MERS-CoVEBOVMARVNiVHeVInhibitorinhibitorinhibit

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