2. Anti-infection
  3. SARS-CoV Hepatitis E Virus (HEV) Filovirus
  4. SCR007

SCR007 is a synthetic carbohydrate receptor (SCR) with broad-spectrum antiviral activity. SCR007 inhibits the entry of enveloped viruses across multiple families (Coronaviridae: SARS-CoV-1, SARS-CoV-2, MERS-CoV; Filoviridae: EBOV, MARV; Paramyxoviridae: NiV, HeV) and the glycosylated nonenveloped rotavirus. SCR007 binds viral envelope N-glycans, blocking viral binding to host cells or both binding and membrane fusion. SCR007 exerts prophylactic effects in hACE2 mice infected with SARS-CoV-2. SCR007 can be used for the study and prevention of enveloped virus pandemics.

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SCR007

SCR007 Chemical Structure

CAS No. : 2409183-72-6

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SCR007 Related Antibodies

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Description

SCR007 is a synthetic carbohydrate receptor (SCR) with broad-spectrum antiviral activity. SCR007 inhibits the entry of enveloped viruses across multiple families (Coronaviridae: SARS-CoV-1, SARS-CoV-2, MERS-CoV; Filoviridae: EBOV, MARV; Paramyxoviridae: NiV, HeV) and the glycosylated nonenveloped rotavirus. SCR007 binds viral envelope N-glycans, blocking viral binding to host cells or both binding and membrane fusion. SCR007 exerts prophylactic effects in hACE2 mice infected with SARS-CoV-2. SCR007 can be used for the study and prevention of enveloped virus pandemics[1].

In Vitro

SCR007 (10-40 μM) ) inhibits infection of SARS-CoV-2 (WA.1 strain), MERS-CoV, EBOV, MARV, NiV, and HeV in PRNT and IFA assays, with potent inhibitory efficacy[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SCR007 Related Antibodies
In Vivo

SCR007 (3 mg/kg, i.n., single dose) improves survival rate in hACE2 mice infected SARS-CoV-2[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: hACE2 knock-in mice (4-5-month-old) were intranasally challenged with 2 × 103 PFU of SARS-CoV-1/2[1]
Dosage: 3 mg/kg
Administration: i.n., single dose
Result: Achieved 90% survival rate.
Reduced lung viral RNA copies by multiple orders of magnitude and brain viral RNA copies significantly.
Decreased perivascular infiltrates and necrotic neurons in lung and brain tissues.
Reduced lung live virus titer.
Decreased pro-inflammatory cytokine levels in bronchoalveolar lavage fluid (BALF), with TNFα, IL-18 and IFN-γ reduced.
Molecular Weight

646.91

Formula

C36H30N4S4
CAS No.
SMILES

C1(C/N=C/C2=CC=CS2)=CC(C3=CC(C/N=C/C4=CC=CS4)=CC(C/N=C/C5=CC=CS5)=C3)=CC(C/N=C/C6=CC=CS6)=C1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SCR007 Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SCR0072409183-72-6SCR 007SCR-007SARS-CoVHepatitis E Virus (HEV)FilovirusSARS coronavirusHepatitis E VirushACE2 miceSARS-CoV-2SARS-CoV-1MERS-CoVEBOVMARVNiVHeVInhibitorinhibitorinhibit

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