Search Result

Results for "

IL-1beta

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Interleukin Related (165) IRAK (1) ADC Cytotoxin (1) Adrenergic Receptor (9) AIM2 (2) Akt (8) Aldehyde Dehydrogenase (ALDH) (2) Aminotransferases (Transaminases) (1) AMPK (4) Amyloid-β (5) Antibiotic (10) AP-1 (2) Apoptosis (26) Autophagy (13) Bacterial (14) Bcl-2 Family (1) Biochemical Assay Reagents (4) Bradykinin Receptor (1) Btk (1) Calcium Channel (3) Cannabinoid Receptor (2) Caspase (26) Cathepsin (2) CD28 (1) CDK (2) Cholecystokinin Receptor (2) Cholinesterase (ChE) (2) Collagen (1) COX (31) Cuproptosis (2) Cytochrome P450 (3) Deubiquitinase (1) Dipeptidyl Peptidase (1) Dopamine Receptor (2) Drug Derivative (2) E1/E2/E3 Enzyme (1) EGFR (1) Endogenous Metabolite (15) Enterovirus (1) Ephrin Receptor (2) Epigenetic Reader Domain (2) ERK (4) Ferroptosis (5) Formyl Peptide Receptor (FPR) (3) FOXO (1) FXR (1) GABA Receptor (2) Glucocorticoid Receptor (4) Glutathione Peroxidase (2) GSK-3 (2) HDAC (2) Heme Oxygenase (HO) (1) HIF/HIF Prolyl-Hydroxylase (6) Histone Acetyltransferase (1) HIV Protease (1) HSP (2) Hydroxycarboxylic Acid Receptor (HCAR) (1) IFNAR (1) IKK (2) Isotope-Labeled Compounds (9) JAK (2) JNK (2) Keap1-Nrf2 (8) Lactate Dehydrogenase (2) Lipoxygenase (3) LPL Receptor (1) MAP3K (5) MAPKAPK2 (MK2) (1) MDM-2/p53 (4) Melanocortin Receptor (1) mGluR (1) MicroRNA (1) Mitochondrial Metabolism (1) Mitophagy (2) MMP (7) Molecular Glues (1) Monoamine Oxidase (3) mTOR (1) MyD88 (4) nAChR (3) NADPH Oxidase (1) NEKs (4) Neurokinin Receptor (1) NF-κB (50) NO Synthase (28) NOD-like Receptor (NLR) (73) P-glycoprotein (2) P2X Receptor (6) P2Y Receptor (1) p38 MAPK (27) Parasite (3) PARP (2) PCSK9 (2) PERK (3) PGC-1α (4) PGE synthase (5) Phosphatase (1) Phosphodiesterase (PDE) (3) Phospholipase (1) PI3K (4) PKA (1) PKC (2) Potassium Channel (3) PPAR (5) PROTACs (3) Proteasome (1) Pyroptosis (11) Pyruvate Kinase (1) Raf (1) Reactive Oxygen Species (16) Reference Standards (2) RIP kinase (1) ROS Kinase (4) SARS-CoV (3) SGLT (1) Small Interfering RNA (siRNA) (2) SOD (3) SphK (1) STAT (4) STING (1) Tau Protein (1) TGF-β Receptor (1) TNF Receptor (64) Toll-like Receptor (TLR) (7) TREM receptor (2) TRP Channel (1) Tyrosinase (3) VEGFR (9) Virus Protease (1) Wnt (2) YTHDF (1) α-synuclein (1)
By Research Areas:	Cancer (69) Cardiovascular Disease (35) Endocrinology (13) Infection (22) Inflammation/Immunology (275) Metabolic Disease (20) Neurological Disease (61)
Click Chemistry:	Alkynes (3)
Oligonucleotides:	Solvents (1) Thickeners (1) Emulsifiers (1) siRNA drugs (2) siRNAs (2)

339

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Peptides

MCE Kits

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oligonucleotides

Lys-D-Pro-Thr	Interleukin Related	Metabolic Disease
Lys-D-Pro-Thr, an IL-1beta analogue, is a potent *IL-1* inhibitor. Lys-D-Pro-Thr inhibits the protective effects of IL-1 beta ^[1] .

IL-1β-IN-1	Interleukin Related	Neurological Disease Inflammation/Immunology
IL-1β-IN-1, cannabidiol derivative, is a potent *IL-1β* inhibitor. IL-1β-IN-1 has anti-inflammatory and pain-resolving properties ^[1].

Ac-YVAD-cmk 10+ Cited Publications Caspase-1 Inhibitor II	Caspase	Inflammation/Immunology
Ac-YVAD-cmk (Caspase-1 Inhibitor II) is a selective *caspase-1* (IL-1beta converting enzyme, ICE)) inhibitor with neuroprotective and anti-inflammatory effects. Ac-YVAD-cmk effectively suppresses the expression of IL-1β and IL-18. Ac-YVAD-cmk inhibits pyroptosis in many diseases ^[1] .

Lysophosphatidylcholine C19:0 1-Nonadecanoyl-2-hydroxy-sn-glycero-3-phosphocholine	Others	Others
Lysophosphatidylcholine C19:0 (1-Nonadecanoyl-2-hydroxy-sn-glycero-3-phosphocholine) is an acyl chain lipid. Lysophosphatidylcholine C19:0 increases IL-1beta secretion ^[1].

Madecassic acid 1 Publications Verification	NO Synthase COX TNF Receptor Interleukin Related	Inflammation/Immunology
Madecassic acid is isolated from Centella asiatica (Umbelliferae). Madecassic acid has anti-inflammatory properties caused by iNOS, COX-2, TNF-alpha, *IL-1beta, and IL-6* inhibition via the downregulation of NF-κB activation in RAW 264.7 macrophage cells ^[1].

Madecassic acid (Standard) 1 Publications Verification	NO Synthase COX TNF Receptor Interleukin Related	Inflammation/Immunology
Madecassic acid (Standard) is the analytical standard of Madecassic acid. This product is intended for research and analytical applications. Madecassic acid is isolated from Centella asiatica (Umbelliferae). Madecassic acid has anti-inflammatory properties caused by iNOS, COX-2, TNF-alpha, *IL-1beta, and IL-6* inhibition via the downregulation of NF-κB activation in RAW 264.7 macrophage cells ^[1].

A 839977 1 Publications Verification	P2X Receptor	Neurological Disease Inflammation/Immunology
A 839977 is a P2X7 selective antagonist; it blocks BzATP-evoked calcium influx at recombinant human, rat and mouse P2X7 receptors (IC₅₀ values are 20 nM, 42 nM and 150 nM respectively) and reduces inflammatory and neuropathic pain in animal models; the antihyperalgesic effects of P2X7 receptor blockade are mediated by blocking the release of IL-1beta ^[1].

Byakangelicol 1 Publications Verification	COX	Inflammation/Immunology
Byakangelicol, isolated from Angelica dahurica, inhibits interleukin-1beta (IL-1beta) -induced prostaglandin E2 (PGE2) release in A549 cells mediated by suppression of cyclooxygenase-2 (COX-2) expression and the activity of COX-2 enzyme. Byakangelicol has therapeutic potential as an anti-inflammatory agent on airway inflammation ^[1].

IL-1β-IN-2	Interleukin Related	Neurological Disease Inflammation/Immunology
IL-1β-IN-2, cannabigerol derivative, is a potent *IL-1β* inhibitor. IL-1β-IN-2 has anti-inflammatory and pain-resolving properties ^[1].

*TNF-α/IL-1β-IN-1*	TNF Receptor Interleukin Related	Cardiovascular Disease
TNF-α/IL-1β-IN-1 (compund 11a) is an anti-inflammatory agent that reduces the expression of TNF-α and IL-1β, inhibits oxidative stress and cardiomyocyte apoptosis, has good activity against septic myocardial injury, and improves myocardial blood supply in vivo ^[1].

β-Sheet Breaker Peptide iAβ5 [Pro18, Asp21] β-Amyloid (17-21)	Amyloid-β	Neurological Disease
β-Sheet Breaker Peptide iAβ5 is an effective brain amyloid-β (Abeta) degrader. Abeta deposits are associated with Alzheimer's disease (AD), and the related toxicity arises from its β-sheet conformation and aggregation. β-Sheet Breaker Peptide iAβ5 can repeatedly induce the degradation of fibrillary amyloid deposits in vivo. Therefore, β-Sheet Breaker Peptide iAβ5 can prevent and/or reverse neuronal contraction caused by Abeta and reduce the range of interleukin IL-1beta positive microglial-like cells around Abeta deposits. β-Sheet Breaker Peptide iAβ5 can reduce the size and/or number of brain amyloid plaques in AD. β-Sheet Breaker Peptide iAβ5 is labeled with a hydrophobic benzyl alcohol (HBA) tag and shows a bright blue color under acidic conditions, which can be used for quantitative determination.

Shegansu B (+)-Shegansu B; Parvifolol D	Interleukin Related	Inflammation/Immunology
Shegansu B is an inhibitor of *IL-1β. Shegansu B 6 inhibits IL-1β expression on LPS-induced THP*-1 cells with 64.74% inhibition. Shegansu B has anti-inflammatory activity ^[1].

GDC-2394	NOD-like Receptor (NLR) Interleukin Related Caspase	Inflammation/Immunology
GDC-2394 is an orally active and selective NLRP3 inhibitor, and also inhibits *IL-1β* with IC₅₀s of 0.4 μM (human IL-1β) and 0.1 μM (mouse IL-1β). GDC-2394 inhibits NLRP3-induced caspase-1 activity without inhibiting NLRC4-dependent inflammasome activation ^[1] .

Canakinumab ILaris; ACZ 885	Interleukin Related	Inflammation/Immunology Cancer
Canakinumab (ACZ885) is a recombinant human *anti-IL-1β* monoclonal antibody. Canakinumab shows IC₅₀ values of 43.6 and 40.8 pM for human and marmoset IL-1β, respectively. The mode of action of canakinumab is based on the neutralization of IL-1β signaling, resulting in suppression of inflammation related to disorders of autoimmune origin ^[1] .

Lutikizumab ABT-981	Interleukin Related	Inflammation/Immunology
Lutikizumab (ABT-981) is an anti-IL-1α and *IL-1β* dual variable domain immunoglobulin. Lutikizumab binds and inhibits IL-1α and IL-1β. Lutikizumab can be used for the research of osteoarthritis ^[1].

Gevokizumab	Interleukin Related	Inflammation/Immunology Cancer
Gevokizumab is a potent anti-IL-1β antibody, negatively modulates *IL-1β* signaling through an allosteric mechanism. Gevokizumab selectively decreases the binding affinity of *IL-1β* for the IL-1 receptor type I (IL-1RI) signaling receptor instead of IL-1 counter-regulatory decoy receptor (IL-1 receptor type II) ^[1] .

TNF-α-IN-19	IKK Interleukin Related TNF Receptor RIP kinase	Others
TNF-α-IN-19 is an inhibitor of TNFα that can block the interaction between TNFαRI, TRADD, and *RIP1, the EC₅₀* values for TNFα, *IL-1β, and IL-1β/TNFα are 2.451, 3.792 and 1.54 μM, respectively. TNF-α-IN-19 only inhibits the degradation of IκBα* when cells are stimulated by TNFα and not by *IL-1β* ^[1].

Armillarisin A	Interleukin Related	Inflammation/Immunology
Armillarisin A has the potential for the ulcerative colitis (UC) study. Armillarisin A increases IL-4 and lower IL-1β ^[1].

Usnoflast	NOD-like Receptor (NLR)	Neurological Disease Inflammation/Immunology
Usnoflast is the selective, orally active inhibitor for NLRP3 that blocks the release of IL-1β, and exhibits anti-inflammatory activity ^[1] .

Ginsenoside Rh1 4 Publications Verification Prosapogenin A2; Sanchinoside B2; Sanchinoside Rh1	Interleukin Related PPAR TNF Receptor Endogenous Metabolite	Inflammation/Immunology
Ginsenoside Rh1 (Prosapogenin A2) inhibits the expression of PPAR-γ, TNF-α, IL-6, and *IL-1β*.

DLX2323	Interleukin Related	Inflammation/Immunology
DLX2323 is an interleukin-1β (IL-1β) modulator. DLX2323 is promising for research of inflammatory diseases ^[1].

Triptobenzene H Hypoglic acid	TNF Receptor	Others
Triptobenzene H (Hypoglic acid) significantly increases TNF-α and IL-1β mRNA levels in macrophages, causing indirect liver damage ^[1].

Kuwanon E	Others	Cancer
Kuwanon E is a flavonoid isolated from Morus alba, cytotoxic to human monocytic leukemic cell lines, and reduces the level of IL-1β ^[1].

Anti-inflammatory agent 76	NO Synthase Interleukin Related	Inflammation/Immunology
Anti-inflammatory agent 76 (Compd 8b), an anti-inflammatory agent, exhibits good NO, *IL-1β* and IL-6 inhibitory activities ^[1].

CP-424174	NOD-like Receptor (NLR)	Inflammation/Immunology
CP-424174 is a reversible inhibitor against *IL-1β* processing with an IC₅₀ of 210 nM.CP-424174 indirectly inhibits NLRP3 ^[1].

MAS825	Interleukin Related	Inflammation/Immunology
MAS825 is a bispecific *IL-1β* and IL-18 monoclonal antibody that reduces inflammasome-mediated inflammation. MAS825 combines the anti-IL-1β and anti-IL-18 monoclonal antibodies (mAbs) inhibition domains in a single bispecific high-affinity cytokine capture molecule ^[1].

GIBH-130 3 Publications Verification	Interleukin Related	Neurological Disease
GIBH-130 is an effective inhibitor of neuroinflammation. GIBH-130 significantly suppresses the *IL-1β* secretion by activated microglia (IC₅₀=3.4 nM).

Dactyllactone A	Interleukin Related	Inflammation/Immunology
Dactyllactone A is an isoquinoline alkaloid that can be isolated from Dactylicapnos scandens. Dactyllactone A shows anti-inflammatory activity. Dactyllactone A inhibits the expression of IL-1β and PGE2 ^[1].

LY2189102	Interleukin Related	Metabolic Disease
LY2189102 is a humanized monoclonal antibody inhibitor targeting interleukin-1β (IL-1β). LY2189102 is promising for research of type 2 diabetes ^[1].

CAY10406	Caspase	Others
CAY10406 is an inhibitor for caspase 3/7. CAY10406 inhibits the expression of 28-kDa IL-1β fragment, without significant cytotoxicity (10 μM) ^[1].

SLP7111228	SphK	Inflammation/Immunology
SLP7111228 is a *SphK1* inhibitor. SLP7111228 reduces LPS-induced TNFα and IL-1β production. SLP7111228 can be used in neuroinflammatory diseases research ^[1].

Ferolin	FXR	Inflammation/Immunology
Ferolin is the agonist for farnesoid X receptor (FXR) with an EC₅₀ of 0.56 µM. Ferolin inhibits the expression of inflammatory genes (such as iNOS, IL-1β and TNFα) upon the FXR activation ^[1].

INX-SM-6	ADC Cytotoxin	Inflammation/Immunology
INX-SM-6 can be used for targeted delivery of anti-inflammatory agent. INX-SM-6 inhibits LPS-induced IL-1β production in human PBMCS ^[1].

Ginsenoside Rc Panaxoside Rc	GABA Receptor TNF Receptor Interleukin Related	Neurological Disease Inflammation/Immunology Cancer
Ginsenoside Rc, one of major Ginsenosides from Panax ginseng, enhances GABA receptor_A (GABA_A)-mediated ion channel currents (I_GABA). Ginsenoside Rc inhibits the expression of TNF-α and *IL-1β*.

NLRP3-IN-57	NOD-like Receptor (NLR)	Inflammation/Immunology
NLRP3-IN-57 (compound 5) inhibits the NLRP3 inflammasome, thereby reducing *IL-1β* levels in LPS plus Nigericin-induced THP-1 macrophages. ^[1].

Methylenedihydrotanshinquinone	Others	Inflammation/Immunology
Methylenedihydrotanshinquinone is a natural product that can be isolated from the dried root of S. miltiorrhiza. Methylenedihydrotanshinquinone has anti-inflammatory effect by inhibiting expression of TNF-α, IL-1β, and IL-8 ^[1].

ZM640	NOD-like Receptor (NLR)	Inflammation/Immunology
ZM640 is a NLRP3 inhibitor. ZM640 enhances IL-1β release mediated by NLRP3 inflammasome activation in THP-1 cells. ZM640 shows low cytotoxicity ^[1].

NLRP3-IN-58	NOD-like Receptor (NLR) Interleukin Related	Inflammation/Immunology
NLRP3-IN-58 (Compound DS15) is an inhibitor for the activation of NLRP3 inflammasome with an IC₅₀ of 3.85 μM, and inhibits 33% IL-1β release at a concentration of 10 μM ^[1].

HP210	Glucocorticoid Receptor	Inflammation/Immunology
HP210 is a selective glucocorticoid receptor modulator (SGRM). HP210 can inhibit the mRNA expression of IL-1β and IL-6. HP210 has the potential to study inflammation-related diseases ^[1].

Lysophosphatidylcholines 1 Publications Verification	Interleukin Related p38 MAPK ERK Apoptosis	Inflammation/Immunology
Lysophosphatidylcholines is an orally active lysolipid and a component of oxidized low density lipoprotein (LDL). Lysophosphatidylcholines induces cell injury, the production of *IL-1β* and apoptosis. Lysophosphatidylcholines has a proactive effect on sepsis ^[1] .

9-POHSA	Endogenous Metabolite	Inflammation/Immunology
9-POHSA is a fatty acid ester of hydroxy fatty acids (FAHFAs). 9-POHSA shows anti-inflammatory effects via inhibiting cytokine production and reduces IL-1β and IL-6 expression ^[1] .

Mincle agonist 1	Interleukin Related	Inflammation/Immunology
Mincle agonist 1 (compound 1c) is a Mincle agonist. Mincle agonist 1 can promote IL-1β expression in BMDM cells. Mincle agonist 1 can be used in immune and inflammation related research ^[1].

Goflikicept RPH 104	Interleukin Related	Cardiovascular Disease Inflammation/Immunology
Goflikicept (RPH 104) is a fusion protein that selectively binds and inactivates both circulating IL-1β and IL-1α. Goflikicept has the potential for the research of ST-segment elevation myocardial infarction (STEMI) ^[1].

NBC19	NOD-like Receptor (NLR)	Inflammation/Immunology
NBC19 is an NLRP3 inflammasome inhibitor with an IC₅₀ of 60 nM in differentiated THP1 cells. NBC19 inhibits nigericin- and ATP-induced IL-1β release with IC₅₀s of 80 nM and 850 nM, respectively ^[1].

SMA-12b	Interleukin Related	Others Inflammation/Immunology
SMA-12b is a small molecule analogue of the parasitic worm compound ES-62. SMA-12b has immunomodulatory activity, acting by regulating the expression of multiple inflammatory response genes, especially those associated with inflammatory bodies. SMA-12b significantly reduces the expression of cytokine *IL-1β* associated with inflammatory bodies and inhibites the production of *IL-1β* through a mechanism mediated by NRF2. SMA-12b can be used in the study of rheumatoid arthritis (RA) and other autoimmune diseases ^[1].

NEK7-IN-1	NEKs	Inflammation/Immunology Cancer
NEK7-IN-1 (Compound I-15) is the inhibitor for NIMA-related kinase 7 NEK7 with IC₅₀ <100 nM. NEK7-IN-1 inhibits the IL-1β release with IC₅₀ <50 nM ^[1].

Cat. No.	Product Name

HY-L156

Autoimmune Disease Compound Library

669 compounds

Autoimmune disease is a pathological disease characterized by inflammatory disorders targeting autoantigens. The routine treatment of autoimmune diseases suppresses general immune function to regulate uncontrolled inflammation. The current targeted immunotherapy suppresses the main pro-inflammatory signaling pathways by blocking inflammatory cytokines, cell surface molecules, and intracellular kinases. As key participants in innate immunity, macrophages and dendritic cells (DCs) are crucial for Ag presentation and pro-inflammatory cytokine production, such as TNF and IL-1 β、 IL-6, IL-23, B cell activating factor (BAFF), and the proliferation-inducing ligand (APRIL, also known as TNFSF13A).

MCE designs a unique collection of 669 autoimmune disease-related compounds, covering multiple targets and subtypes, such as TNF Receptor, IFNAR, JAK, Btk, TLR, IL-6, IL-17, IL-23, etc. It is a useful tool for screening autoimmune disease drugs.

Cat. No.	Product Name	Type

HY-139414

Lysophosphatidylcholines 1 Publications Verification	Cell Assay Reagents
Lysophosphatidylcholines is an orally active lysolipid and a component of oxidized low density lipoprotein (LDL). Lysophosphatidylcholines induces cell injury, the production of *IL-1β* and apoptosis. Lysophosphatidylcholines has a proactive effect on sepsis ^[1] .

HY-W104821

Rosolic acid	Indicators
Rosolic Acid is an activator of Nrf2, as well as its downstream targets. Rosolic Acid increases the levels of angiogenic factors, decreases inflammation (TNF-α and *IL-1β) and apoptotic markers (CXCL10* and CCL2). Rosolic Acid restores the function of pancreatic cells and protects endothelial cells (ECs) from endoplasmic reticulum stressed ^[1].

HY-159669

Stercobilin hydrochloride (mixture of isomers)

Cell Assay Reagents

Stercobilin hydrochloride (amixture of isomers) is a bile pigment metabolized by gut bacteria, and it's also an HIV protease inhibitor, with a K_i of 4 μM. Stercobilin hydrochloride (a mixture of isomers) can induce pro-inflammatory activity in mouse macrophage RAW264 cells, including the production of TNF-α and IL-1β. Stercobilin hydrochloride (a mixture of isomers) can be used in studies of inflammation and viral infections ^[1] .

HY-W145695

Chitoheptaose

Biochemical Assay Reagents

Chitoheptaose is a chitosan oligosaccharide. Chitoheptaose is capable of extracting exoskeletons from crustaceans, such as the shells of crabs, shrimp and lobsters. Chitoheptaose has antioxidant, anti-inflammatory and anti-apoptotic activities and can be used in the study of myocarditis. Chitoheptaose has cardioprotective effects and improves cardiac parameters (left ventricular internal size, end-systolic and end-diastolic, ejection fraction and shortening fraction), inflammatory cytokines (IL-1β) in vanishing models ^[1].

HY-W342458

Betamethasone 17-Propionate

Cell Assay Reagents

Betamethasone 17-Propionate is a compound used to study its effects on endotoxin-induced uveitis in rats. It has the activity of inhibiting the infiltration of cells into the aqueous humor in endotoxin-induced uveitis by eye drops and systemic administration at a certain dose. However, its inhibitory effect is relatively weak compared with some other compounds. At the same time, the dose for systemic administration is 1mg/kg. In addition, Betamethasone 17-Propionate has a weaker inhibitory effect on the release of IL-8 from rat peritoneal exudate cells in an in vitro interleukin-8 (IL-8) release assay than betamethasone. Moreover, the simultaneous addition of betamethasone dipropionate and betamethasone 17-Propionate reduces the inhibitory effect of betamethasone on cell infiltration and IL-1β gene expression.

Cat. No.	Product Name	Target	Research Area

HY-125083

Lys-D-Pro-Thr	Interleukin Related	Metabolic Disease
Lys-D-Pro-Thr, an IL-1beta analogue, is a potent *IL-1* inhibitor. Lys-D-Pro-Thr inhibits the protective effects of IL-1 beta ^[1] .

HY-P1047

β-Sheet Breaker Peptide iAβ5 [Pro18, Asp21] β-Amyloid (17-21)	Amyloid-β	Neurological Disease
β-Sheet Breaker Peptide iAβ5 is an effective brain amyloid-β (Abeta) degrader. Abeta deposits are associated with Alzheimer's disease (AD), and the related toxicity arises from its β-sheet conformation and aggregation. β-Sheet Breaker Peptide iAβ5 can repeatedly induce the degradation of fibrillary amyloid deposits in vivo. Therefore, β-Sheet Breaker Peptide iAβ5 can prevent and/or reverse neuronal contraction caused by Abeta and reduce the range of interleukin IL-1beta positive microglial-like cells around Abeta deposits. β-Sheet Breaker Peptide iAβ5 can reduce the size and/or number of brain amyloid plaques in AD. β-Sheet Breaker Peptide iAβ5 is labeled with a hydrophobic benzyl alcohol (HBA) tag and shows a bright blue color under acidic conditions, which can be used for quantitative determination.

HY-P3042

Chymostatin	SARS-CoV Virus Protease NF-κB Interleukin Related	Inflammation/Immunology
Chymostatin is a SARS-CoV-2 M ^pro inhibitor. Chymostatin up-regulates endocan and inhibits NF-κBp65 activity. Chymostatin reduces proinflammatory cytokines (IL-1β and IL-6) and *HMGB1*. Chymostatin shows protective effects against Paraquat-induced acute lung injury. Chymostatin exhibits anticancer activity against lung cancer ^[1] .

HY-P3211A

Nangibotide TFA 3 Publications Verification LR12 TFA	TREM receptor NF-κB NOD-like Receptor (NLR) Interleukin Related Apoptosis	Cardiovascular Disease Inflammation/Immunology
Nangibotide TFA (LR12 TFA) is a synthetic peptide and *TREM-1* receptor inhibitor. Nangibotide TFA inhibits NF-κB and NLRP3 inflammasome activation and reduces the release of pro-inflammatory factors (such as *IL-1β, IL-8). Nangibotide TFA inhibits Apoptosis*. Nangibotide TFA reduces excessive inflammatory responses and protects tissues (liver, lung) from damage. Nangibotide TFA can be used in the researches for myocardial ischemia-reperfusion injury, septic shock, acute lung injury, osteoarthritis, and acute liver failure ^[1] .

HY-113893

β-Interleukin I (163-171), human	Peptides	Inflammation/Immunology
β-Interleukin I (163-171), human, an immunostimulatory fragment of human IL-1β peptide, is a T cell activator. β-Interleukin I (163-171), human is not an IL-1R-binding domain of IL-1β. β-Interleukin I (163-171), human is a potent adjuvant that enhances the immune response in a variety of exptl. situations ^[1] .

HY-P4285

β-Aspartylalanine	Peptides	Others
β-Aspartylalanine is a substrate for β-aspartyl peptidase and used to measure β-aspartyl peptidase activity in fecal supernatants ^[1].

HY-W650842

Boc-Asp(OBzl)-CMK	Caspase	Cancer
Boc-Asp(OBzl)-CMK is an inhibitor for IL-1 converting enzyme (ICE, caspase1). Boc-Asp(OBzl)-CMK prevents death of CHP100 neuroblastoma cell, and IL-1β release elicited by the viral coat protein ^[1].

HY-P10796

YARA peptide	MAPKAPK2 (MK2)	Inflammation/Immunology
YARA peptide, a cell-penetrating peptide, is a MK2 inhibitor. YARA-loaded nanoparticles decreases the levels of inflammatory cytokines (IL-1β, IL-6, and TNF-α) in an ex vivo skin culture model. YARA peptide is promising for research of atopic dermatitis (AD) ^[1].

HY-P0109

(S,S)-Z-FA-FMK	Cathepsin	Others
(S,S)-Z-FA-FMK is a cell-permeable, irreversible cathepsin B inhibitor. (S,S)-Z-FA-FMK blocks LPS-induced production of IL-1α and IL-1β. (S,S)-Z-FA-FMK can be used as a negative control for caspase-1 and caspase-2 inhibitors because it lacks an aspartic acid residue at the P1 position ^[1] .

HY-P3211

Nangibotide LR12	TREM receptor NF-κB NOD-like Receptor (NLR) Interleukin Related Apoptosis	Cardiovascular Disease Inflammation/Immunology
Nangibotide (LR12) is a synthetic peptide and *TREM-1* receptor inhibitor. Nangibotide inhibits NF-κB and NLRP3 inflammasome activation and reduces the release of pro-inflammatory factors (such as *IL-1β, IL-8). Nangibotide inhibits Apoptosis*. Nangibotide reduces excessive inflammatory responses and protects tissues (liver, lung) from damage. Nangibotide can be used in the researches for myocardial ischemia-reperfusion injury, septic shock, acute lung injury, osteoarthritis, and acute liver failure ^[1] .

HY-P10935

Amilo-5MER 5-MP	Amyloid-β Interleukin Related	Inflammation/Immunology
Amilo-5MER (5-MP) is an orally active and selective Serum Amyloid A (SAA) inhibitor. Amilo-5MER specifically inhibits the release of pro-inflammatory cytokines IL-6 and IL-1β from SAA-activated cells. Amilo-5MER reduces chronic inflammation and relieves symptoms of diseases such as rheumatoid arthritis (RA), inflammatory bowel disease (IBD), and multiple sclerosis (MS). Amilo-5MER is promising for research of autoimmune diseases and chronic inflammatory diseases ^[1].

HY-P10935A

Amilo-5MER TFA 5-MP TFA	Amyloid-β Interleukin Related	Inflammation/Immunology
Amilo-5MER (5-MP) TFA is an orally active and selective Serum Amyloid A (SAA) inhibitor. Amilo-5MER TFA specifically inhibits the release of pro-inflammatory cytokines IL-6 and IL-1β from SAA-activated cells. Amilo-5MER TFA reduces chronic inflammation and relieves symptoms of diseases such as rheumatoid arthritis (RA), inflammatory bowel disease (IBD), and multiple sclerosis (MS). Amilo-5MER TFA is promising for research of autoimmune diseases and chronic inflammatory diseases ^[1].

HY-P5189A

*His-D-beta-Nal-Ala-Trp-D-Phe-Lys-NH2 TFA*	Endogenous Metabolite Cholinesterase (ChE)	Others
His-D-beta-Nal-Ala-Trp-D-Phe-Lys-NH2 TFA, is a growth hormone releasing peptide, as well as a metabolite of GHRP-1. GHRP-1, or Ala-His-D-beta Nal-Ala-Trp-D-Phe-Lys-NH2, has the effect of promoting the release of growth hormone (GH). GHRP-1 increases GH release and increases [Ca2+]i levels in static monolayer cells of rat pituitary gland, but does not affect cAMP levels ^[1].

HY-P2630

Suc-YVAD-pNA	Interleukin Related	Inflammation/Immunology
Suc-YVAD-pNA is a substrate of ICE. Interleukin-1β-converting enzyme (ICE) is a cysteine protease responsible for the cleavage of pre-interleukin-1β (pre-IL-1β) to the mature cytokine and a member of a family of related proteases (the caspases) ^[1].

HY-103291

Sar-[D-Phe8]-des-Arg9-Bradykinin	Bradykinin Receptor	Inflammation/Immunology Endocrinology
Sar-[D-Phe8]-des-Arg9-Bradykinin is a agonist of B1 receptor. Sar-[D-Phe8]-des-Arg9-Bradykinin selectively amplifies the contractile response when incubation with human recombinant interleukin-1 β (IL-1 β) in rabbit aortic rings ^[1].

Cat. No.	Product Name

HY-K2116

*HOLO Human Interleukin-1β (IL-1β) Detection Kit*
MCE HOLO Human Interleukin-1β (IL-1β) Detection Kit is a homogeneous luminescence-based assay used for the quantitative detection of human IL-1β concentrations in biological samples such as buffer solutions, cell culture supernatants, or serum.

Cat. No.	Product Name	Target	Research Area

HY-108810

Canakinumab ILaris; ACZ 885	Interleukin Related	Inflammation/Immunology Cancer
Canakinumab (ACZ885) is a recombinant human *anti-IL-1β* monoclonal antibody. Canakinumab shows IC₅₀ values of 43.6 and 40.8 pM for human and marmoset IL-1β, respectively. The mode of action of canakinumab is based on the neutralization of IL-1β signaling, resulting in suppression of inflammation related to disorders of autoimmune origin ^[1] .

HY-P99721

Lutikizumab ABT-981	Interleukin Related	Inflammation/Immunology
Lutikizumab (ABT-981) is an anti-IL-1α and *IL-1β* dual variable domain immunoglobulin. Lutikizumab binds and inhibits IL-1α and IL-1β. Lutikizumab can be used for the research of osteoarthritis ^[1].

HY-P99171

Gevokizumab	Interleukin Related	Inflammation/Immunology Cancer
Gevokizumab is a potent anti-IL-1β antibody, negatively modulates *IL-1β* signaling through an allosteric mechanism. Gevokizumab selectively decreases the binding affinity of *IL-1β* for the IL-1 receptor type I (IL-1RI) signaling receptor instead of IL-1 counter-regulatory decoy receptor (IL-1 receptor type II) ^[1] .

HY-P99645

Goflikicept RPH 104	Interleukin Related	Cardiovascular Disease Inflammation/Immunology
Goflikicept (RPH 104) is a fusion protein that selectively binds and inactivates both circulating IL-1β and IL-1α. Goflikicept has the potential for the research of ST-segment elevation myocardial infarction (STEMI) ^[1].

HY-P99111

Golimumab CNTO-148	TNF Receptor Apoptosis Interleukin Related Caspase	Inflammation/Immunology Cancer
Golimumab (CNTO-148) is a potent human IgG1 TNFα antagonist monoclonal antibody. Golimumab has anti-inflammation activitity and inhibits IL-6 and IL-1β production. Golimumab acts via targeting and neutralizing TNF to prevent inflammation and destruction of cartilage and bone. Golimumab has the anticancer activity and induces cell apoptosis. Golimumab can be used for rheumatoid arthritis, Crohn's disease and cancer research ^[1] .

HY-P991268

DLX2323	Interleukin Related	Inflammation/Immunology
DLX2323 is an interleukin-1β (IL-1β) modulator. DLX2323 is promising for research of inflammatory diseases ^[1].

HY-P991083

MAS825	Interleukin Related	Inflammation/Immunology
MAS825 is a bispecific *IL-1β* and IL-18 monoclonal antibody that reduces inflammasome-mediated inflammation. MAS825 combines the anti-IL-1β and anti-IL-18 monoclonal antibodies (mAbs) inhibition domains in a single bispecific high-affinity cytokine capture molecule ^[1].

HY-P991269

LY2189102	Interleukin Related	Metabolic Disease
LY2189102 is a humanized monoclonal antibody inhibitor targeting interleukin-1β (IL-1β). LY2189102 is promising for research of type 2 diabetes ^[1].

HY-P991138

Firsekibart	Interleukin Related	Inflammation/Immunology
Firsekibart is an immunoglobulin G4-λ2 monoclonal antibody targeting human interleukin 1β (IL-1β). Firsekibart is promising for research of inflammation-related diseases, such as rheumatoid arthritis and inflammatory bowel disease ^[1].

HY-P991118

Arumakimig	Interleukin Related	Inflammation/Immunology
Arumakimig is a bispecific humanized anti-IL-18 and anti-IL-1β antibody. Arumakimig can be used in anti-inflammatory research ^[1].

HY-P99555

Tomaralimab OPN-305	Toll-like Receptor (TLR) MyD88 NOD-like Receptor (NLR) Tau Protein Interleukin Related	Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
Tomaralimab (OPN-305) is a humanized anti-TLR2 IgG4 monoclonal antibody. Tomaralimab inhibits TLR2, MyD88, NLRP3, and reduces pro-inflammatory cytokine (IL-1β, IL-6, IL-8) production. Tomaralimab reduces tau pathology. Tomaralimab improves cognition, atopic dermatitis. Tomaralimab has anticancer effects on pancreatic ductal adenocarcinoma. Tomaralimab is being studied in myelodysplastic syndrome (MDS), atopic dermatitis, pancreatic ductal adenocarcinoma, Alzheimer's disease, and myocardial ischemia/reperfusion injury ^[1] .

HY-P99379

Nidanilimab (Nadunolimab) CAN04; Anti-IL-1RAP/IL-1R3 Reference Antibody (nidanILimab)	Interleukin Related	Cancer
Nidanilimab (CAN04) is a fully humanized monoclonal *anti-IL1RAP* antibody with a K_d value of 1.10 pM. Nidanilimab blocks IL1α and IL1β signaling and stimulates the immune system to destroy tumour cells. Nidanilimab can be used in research of non-small lung cancer (NSCLC) and pancreatic ductal adenocarcinoma (PDAC) ^[1] .

Recombinant Proteins Recommended:

IL-1 beta

Species:	Human (15) Rhesus Macaque (1) Mouse (6) Rat (3) Cynomolgus (3) Cat (1) Rabbit (1) Canine (2) Pig (2)
Tag:	His (20) Tag Free (13) Avi (6) GST (1) Fc (1)
Source:	HEK293 (3) CHO (2) P. pastoris (1) E. coli (29)

Cat. No.	Compare	Product Name	Species	Source

HY-P78585

	IL-1 beta Protein, Cynomolgus (His) IL1B; IL-1beta; IL1F2; IL-1β	Cynomolgus	E. coli
	IL-1 beta is a potent proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. IL-1 beta plays a key role in inflammation and immunologic reactions. IL-1 beta Protein, Cynomolgus (His) is produced in E. coli with a N-Terminal His-tag. It consists of 152 amino acids (A117-S268).

HY-P78143

	IL-1 beta Protein, Human (Biotinylated, His-Avi) Interleukin-1 beta; IL-1 beta; IL1F2; IL1B; IL-1beta; IL1F2; IL-1β; IL-1 beta; IL-1B ; Interleukin-1 β; IL-1 β; IL-1β; IL-1 β	Human	E. coli
	IL-1 beta is a potent proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. IL-1 beta plays a key role in inflammation and immunologic reactions. IL-1 beta Protein, Human (Biotinylated, His-Avi), a Biotinylated IL-1 beta protein, is produced in E. coli with a C-Terminal His-tag and a C-Terminal Avi-tag. It consists of 153 amino acids (A117-S269).

HY-P78459

	IL-1 beta Protein, Human (His-Avi) 1 Publications Verification Interleukin-1 beta; IL-1 beta; IL1F2; IL1B; IL-1beta; IL1F2; IL-1β; IL-1 beta; IL-1B ; Interleukin-1 β; IL-1 β; IL-1β; IL-1 β	Human	E. coli
	IL-1 beta is a potent proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. IL-1 beta plays a key role in inflammation and immunologic reactions. IL-1 beta Protein, Human (His-Avi) is produced in E. coli with a C-Terminal His-tag and a C-Terminal Avi-tag. It consists of 153 amino acids (A117-S269).

HY-P700254

	IL-1 beta Protein, Human (N-His) Interleukin-1 beta; IL-1 beta; IL1F2; IL1B; IL-1beta; IL1F2; IL-1β; IL-1 beta; IL-1B ; Interleukin-1 β; IL-1 β; IL-1β; IL-1 β	Human	E. coli
	IL-1 beta protein is a potent proinflammatory cytokine that plays multiple roles in immune responses. It induces inflammatory events including prostaglandin synthesis, neutrophil activation, and cytokine production. IL-1 beta Protein, Human (N-His) is the recombinant human-derived IL-1beta protein, expressed by E. coli , with N-6*His labeled tag.

HY-P78459A

	IL-1 beta Protein, Human (C-His) 1 Publications Verification Interleukin-1 beta; IL-1 beta; IL1F2; IL1B; IL-1beta; IL1F2; IL-1β; IL-1 beta; IL-1B ; Interleukin-1 β; IL-1 β; IL-1β; IL-1 β	Human	E. coli
	IL-1 beta protein is a potent proinflammatory cytokine that plays multiple roles in immune responses. It induces inflammatory events including prostaglandin synthesis, neutrophil activation, and cytokine production. IL-1 beta Protein, Human (C-His) is the recombinant human-derived IL-1 beta protein, expressed by E. coli , with C-6*His labeled tag.

HY-P703969

	IL-1 beta Protein, Mouse (His, Avi) Interleukin-1 beta; IL-1 beta; IL1F2; IL1B; IL-1beta; IL1F2; IL-1β; IL-1 beta; IL-1B ; Interleukin-1 β; IL-1 β; IL-1β; IL-1 β	Mouse	E. coli

HY-P703839

	IL-1 beta Protein, Cynomolgus (Biotinylated, HEK293, His, Avi) IL1B; IL-1beta; IL1F2; IL-1β	Cynomolgus	HEK293

HY-P703962

	IL-1 beta Protein, Cynomolgus (Biotinylated, His, Avi) Interleukin-1 beta; IL-1 beta; IL1F2; IL1B; IL-1beta; IL1F2; IL-1β; IL-1 beta; IL-1B ; Interleukin-1 β; IL-1 β; IL-1β; IL-1 β	Cynomolgus	E. coli

HY-P703968

	IL-1 beta Protein, Mouse (Biotinylated, His, Avi) Interleukin-1 beta; IL-1 beta; IL1F2; IL1B; IL-1beta; IL1F2; IL-1β; IL-1 beta; IL-1B ; Interleukin-1 β; IL-1 β; IL-1β; IL-1 β	Mouse	E. coli

HY-P704378

	IL-1 beta Protein, Human (HEK293, hFc) Interleukin-1 beta; IL-1 beta; IL1F2; IL1B; IL-1beta; IL1F2; IL-1β; IL-1 beta; IL-1B ; Interleukin-1 β; IL-1 β; IL-1β; IL-1 β	Human	HEK293

HY-P73146

	IL-1 beta Protein, Canine Interleukin-1 beta; IL-1β; IL1F2; IL-1 beta; IL1B	Canine	E. coli
	IL-1 beta is a potent proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. IL-1 beta plays a key role in inflammation and immunologic reactions. IL-1 beta Protein, Canine consists of 152 amino acids (A115-S266) and is expressed in E. coli.

HY-P73148

	IL-1 beta Protein, Feline Interleukin-1 beta; IL-1β; IL1F2; IL-1 beta; IL1B	Cat	E. coli
	IL-1 beta is a potent proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. IL-1 beta plays a key role in inflammation and immunologic reactions. IL-1 beta Protein, Feline consists of 152 amino acids (A116-S267) and is expressed in E. coli.

HY-P73150

	IL-1 beta Protein, Rabbit Interleukin-1 beta; IL-1β; IL1F2; IL-1 beta; IL1B	Rabbit	E. coli
	IL-1 beta is a potent proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. IL-1 beta plays a key role in inflammation and immunologic reactions. IL-1 beta Protein, Rabbit consists of 152 amino acids (A117-S268) and is expressed in E. coli.

HY-P73149

	IL-1 beta Protein, Human (E6K, His) 5 Publications Verification Interleukin-1 beta; IL-1β; IL1F2; IL-1 beta; IL1B	Human	E. coli
	IL-1 beta is a potent proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. IL-1 beta plays a key role in inflammation and immunologic reactions. IL-1 beta Protein, Human (E6K, His) is produced in E. coli with a N-Terminal His-tag. It consists of 269 amino acids (M1-S269).

HY-P73900

	IL-1 beta Protein, Rat (268a.a, His) 3 Publications Verification Interleukin-1 beta; IL-1β; IL1F2; IL-1 beta; IL1B	Rat	E. coli
	IL-1 beta is a potent proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. IL-1 beta plays a key role in inflammation and immunologic reactions. IL-1 beta Protein, Rat (268a.a, His) is produced in E. coli with a N-Terminal His-tag. It consists of 268 amino acids (M1-S268).

HY-P72571

	IL-1 beta Protein, Cavia porcellus (His) Interleukin-1 beta; IL-1 beta; IL1B	Others	E. coli
	IL-1 beta is a potent proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. IL-1 beta plays a key role in inflammation and immunologic reactions. IL-1 beta Protein, Cavia porcellus (His) is produced in E. coli with six C-Terminal His-tags. It consists of 152 amino acids (T115-S266).

HY-P7206

	IL-1 beta Protein, Pig 1 Publications Verification rPoIL-1β; IL1B	Pig	E. coli
	IL-1 beta is a potent proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. IL-1 beta plays a key role in inflammation and immunologic reactions. IL-1 beta Protein,Pig consists of 153 amino acids (A115-P267) and is expressed in E. coli.

HY-P7207

	IL-1 beta Protein, Rhesus macaque rRhIL-1β; IL1B	Rhesus Macaque	E. coli
	IL-1 beta is a potent proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. IL-1 beta plays a key role in inflammation and immunologic reactions. IL-1 beta Protein, Rhesus macaque consists of 153 amino acids (A117-S269) and is expressed in E. coli.

HY-P7205

	IL-1 beta Protein, Human (CHO) 2 Publications Verification rHuIL-1β; Catabolin; IL1F2; IL1B	Human	CHO
	IL-1 beta is a potent proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. IL-1 beta plays a key role in inflammation and immunologic reactions. IL-1 beta Protein, Human (CHO) is produced in CHO cells, and consists of 153 amino acids (A117-S269).

HY-P73146A

	IL-1 beta Protein, Canine (Tag free) Interleukin-1 beta; IL-1β; IL1F2; IL-1 beta; IL1B	Canine	E. coli
	IL-1 beta Protein, Canine (Tag free) is the recombinant canine-derived IL-1 beta, expressed by E. coli , with tag Free labeled tag.

HY-P7028

	IL-1 beta Protein, Human Maximum Cited Publications 34 Publications Verification rHuIL-1β; Catabolin; IL1F2; IL-1 beta; IL1B	Human	E. coli
	IL-1 beta is a potent proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. IL-1 beta plays a key role in inflammation and immunologic reactions. IL-1 beta is produced as inactive pro-IL-1β (encoded by pro-Il-1b) in response to inflammatory stimuli. IL-1 beta Protein, Human consists of 153 amino acids (A117-S269) and is expressed in E. coli.

HY-P7073

	IL-1 beta Protein, Mouse 20+ Cited Publications rMuIL-1β; Catabolin; IL1F2; IL-1 beta; IL1B	Mouse	E. coli
	IL-1 beta is a potent proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. IL-1 beta plays a key role in inflammation and immunologic reactions. IL-1 beta Protein, Mouse consists of 152 amino acids (V118-S269) and is expressed in E. coli.

HY-P7097

	IL-1 beta Protein, Rat 10+ Cited Publications rRtIL-1β; Catabolin; IL1F2; IL-1 beta; IL1B	Rat	E. coli
	IL-1 beta is a potent proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. IL-1 beta plays a key role in inflammation and immunologic reactions. IL-1 beta Protein, Rat is expressed in E. coli.

HY-P7097A

	IL-1 beta Protein, Rat (His) 2 Publications Verification rRtIL-1β; Catabolin; IL1F2; IL-1 beta; IL1B	Rat	E. coli
	IL-1 beta protein is a potent proinflammatory cytokine and endogenous pyrogen that induces multiple inflammatory responses, including prostaglandin synthesis, neutrophil, T-cell and B-cell activation, and fibroblast proliferation. It promotes Th17 differentiation, synergizes with IL12 to promote IFNG synthesis, and induces VEGF production through TNF and IL6 to promote angiogenesis. IL-1 beta Protein, Rat (His) is the recombinant rat-derived IL-1 beta protein, expressed by E. coli , with N-6*His labeled tag.

HY-P7073A

	IL-1 beta Protein, Mouse (CHO) 3 Publications Verification rMuIL-1β; Catabolin; IL1F2; IL-1 beta; IL1B	Mouse	CHO
	IL-1 beta is a potent proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. IL-1 beta plays a key role in inflammation and immunologic reactions. IL-1 beta Protein, Mouse (CHO) is produced in CHO cells, and consists of 152 amino acids (V118-S269).

HY-P70586

	IL-1 beta Protein, Human (solution) Interleukin-1 beta; Catabolin; IL1F2; IL1B.	Human	E. coli
	IL-1 beta protein is a potent proinflammatory cytokine that plays multiple roles in immune responses. It induces inflammatory events including prostaglandin synthesis, neutrophil activation, and cytokine production. IL-1 beta Protein, Human (solution) is the recombinant human-derived IL-1 beta protein, expressed by E. coli , with tag free.

HY-P700096AF

	*Animal-Free IL-1* beta Protein, Human (His)** Interleukin-1 beta; IL-1 beta; IL1F2; IL1B; IL-1beta; IL1F2; IL-1β; IL-1 beta; IL-1B ; Interleukin-1 β; IL-1 β; IL-1β; IL-1 β	Human	E. coli
	IL-1 beta protein is a potent proinflammatory cytokine that plays multiple roles in immune responses. It induces inflammatory events including prostaglandin synthesis, neutrophil activation, and cytokine production. Animal-Free IL-1 beta Protein, Human (His) is the recombinant human-derived animal-FreeIL-1 beta protein, expressed by E. coli , with C-His labeled tag. This product is for cell culture use only.

HY-P700243AF

	*Animal-Free IL-1* beta Protein, Pig (His)** Interleukin-1 beta; IL-1β; IL1F2; IL-1 beta; IL1B	Pig	E. coli
	IL-1 beta protein is a potent proinflammatory cytokine that initiates various immune responses, including prostaglandin synthesis, neutrophil recruitment, T cell cytokine production, B cell activation, fibroblast proliferation, and collagen produce. It promotes Th17 differentiation, synergizes with IL12 to promote IFNG synthesis by Th1 cells, and induces angiogenesis together with TNF and IL6. Animal-Free IL-1 beta Protein, Pig (His) is the recombinant pig-derived animal-FreeIL-1 beta protein, expressed by E. coli , with C-His labeled tag. This product is for cell culture use only.

HY-P700187AF

	*Animal-Free IL-1* beta Protein, Mouse (His)** rMuIL-1β; Catabolin; IL1F2; IL-1 beta; IL1B	Mouse	E. coli
	IL-1 beta protein is a potent pro-inflammatory cytokine and major endogenous pyrogen that induces immune cell effects such as prostaglandin synthesis, neutrophil activation, T- and B-cell activation, and fibroblast proliferation . It promotes Th17 differentiation and synergizes with IL12 to promote Th1 IFNG synthesis. Animal-Free IL-1 beta Protein, Mouse (His) is the recombinant mouse-derived animal-FreeIL-1 beta protein, expressed by E. coli , with C-His labeled tag. This product is for cell culture use only.

HY-P70586G

	*GMP IL-1* beta Protein, Human** Interleukin-1 beta; Catabolin; IL1F2; IL1B	Human	E. coli
	IL-1 beta is a potent proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. IL-1 beta plays a key role in inflammation and immunologic reactions. GMP IL-1 beta Protein, Human, is a recombinant GMP-grade protein, consists of 153 amino acids (A117-S269) and is expressed in E. coli.

HY-P71246

	PTX3 Protein, Mouse (HEK293, His) alpha-induced protein 5; pentaxin-related gene, rapidly induced by IL-1 beta, tumor necrosis factor; Pentaxin-related protein PTX3; Pentraxin 3; pentraxin 3, long; pentraxin-3; pentraxin-related gene, rapidly induced by IL-1 beta; pentraxin-related protein PTX3;	Mouse	HEK293
	PTX3 Protein, pivotal in innate pathogen resistance and inflammation regulation, may contribute to self-component clearance and female fertility.As a homooctamer with disulfide-linked structures, PTX3's multifaceted nature maintains immune homeostasis.Interaction with C1q underscores its significance in innate immune responses, positioning PTX3 as a key player in pathogen defense and inflammatory modulation.PTX3 Protein, Mouse (HEK293, His) is the recombinant mouse-derived PTX3 protein, expressed by HEK293 , with N-6*His labeled tag.

HY-P72117

	Caspase-1/CASP1 p20 Protein, Human (GST) CASP-1; CASP1; CASP1_HUMAN; Caspase 1; ICE; IL-1 beta-converting enzyme; IL-1BC; IL1 beta converting enzyme; IL1B convertase; Interleukin 1 beta convertase; Interleukin 1B converting enzyme; Interleukin-1 beta convertase; Interleukin-1 beta-converting enzyme; p45	Human	E. coli
	Caspase-1/CASP1 is a thiol protease complex involved in inflammation by catalyzing the cleavage of IL1B, IL18, and Gasdermin-D (GSDMD). It activates a pro-inflammatory response, releases mature cytokines IL1B and IL18, and initiates pyroptosis through cleavage of GSDMD. Caspase-1/CASP1 Protein, Human (GST) is the recombinant human-derived Caspase-1/CASP1 protein, expressed by E. coli , with N-GST labeled tag.

HY-P704428

	Caspase-1/CASP1 Protein, Human (His) CASP-1; CASP1; CASP1_HUMAN; Caspase 1; ICE; IL-1 beta-converting enzyme; IL-1BC; IL1 beta converting enzyme; IL1B convertase; Interleukin 1 beta convertase; Interleukin 1B converting enzyme; Interleukin-1 beta convertase; Interleukin-1 beta-converting enzyme; p45	Human	E. coli

HY-P703076

	Caspase-1/CASP1 Protein, Human (Active, T388A, His) CASP-1; CASP1; CASP1_HUMAN; Caspase 1; ICE; IL-1 beta-converting enzyme; IL-1BC; IL1 beta converting enzyme; IL1B convertase; Interleukin 1 beta convertase; Interleukin 1B converting enzyme; Interleukin-1 beta convertase; Interleukin-1 beta-converting enzyme; p45	Human	E. coli
	Caspase-1/CASP1 protein is a thiol protease complex involved in inflammation by catalyzing the cleavage of IL1B, IL18, and Gasdermin-D (GSDMD). It activates a pro-inflammatory response, releases mature cytokines IL1B and IL18, and initiates pyroptosis through cleavage of GSDMD. Caspase-1/CASP1 Protein, Human (Active, T388A, His) is the recombinant human-derived Caspase-1/CASP1, expressed by E. coli , with N-His labeled tag. ,

HY-P700624

	RIPK2 Protein, Human (P. pastoris, His) receptor-interacting serine-threonine kinase 2; receptor-interacting serine/threonine-protein kinase 2; CARD3; CARDIAK; RICK; RIP2; RIP-2; CARD-carrying kinase; growth-inhibiting gene 30; tyrosine-protein kinase RIPK2; receptor interacting protein 2; receptor-interacting protein 2; RIP-like-interacting CLARP kinase; CARD-containing IL-1 beta ICE-kinase; CARD-containing interleukin-1 beta-converting enzyme-associated kinase; CARD-containing interleukin-1 beta-converting enzyme (ICE)-associated kinase; receptor-interacting protein (RIP)-like interacting caspase-like apoptosis regulatory protein (CLARP) kinase; CCK; GIG30;	Human	P. pastoris
	RIPK2 is a multifunctional serine/threonine/tyrosine protein kinase that coordinates innate and adaptive immune responses. It is activated by bacterial peptidoglycan to form filaments in the NOD1 and NOD2 pathways, undergoing autophosphorylation and polyubiquitination. RIPK2 Protein, Human (P. pastoris, His) is the recombinant human-derived RIPK2 protein, expressed by P. pastoris , with C-6His, C-6His labeled tag.

Compare Products


Products	In-stock - + Add to Cart
Cat. No.
Species
Source
Tag
Accession
Gene ID
Molecular Weight
Purity
Endotoxin Level
Biological Activity
Appearance
Formulation
Storage & Stability
Shipping
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P80503

	IL-1 beta Antibody (YA345)	WB, ICC/IF, IHC-P, FC	Human
	IL-1 beta Antibody (YA345) is a non-conjugated and Rabbit origined monoclonal antibody about 31 kDa, targeting to IL-1 beta. It can be used for WB,ICC/IF,IHC-P,FC assays with tag free, in the background of Human.

HY-P80720

	IL-1 beta Antibody 5 Publications Verification IL1B; IL1F2; Interleukin-1 beta; IL-1 beta; Catabolin	WB, IHC-P, ICC/IF	Human, Mouse, Rat
	IL-1 beta Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 17 kDa, targeting to IL-1 beta. It can be used for WB,IHC-P,ICC/IF assays with tag free, in the background of Human, Mouse, Rat.

HY-P81232

	Caspase-1 Antibody caspase-1 isoform alpha subunit; CASP1; ICE; IL1BC; Caspase-1 subunit p20; CASP 1; Caspase 1 apoptosis related cysteine peptidase; Caspase 1 apoptosis related cysteine protease; Caspase1; IL 1 beta converting enzyme; IL 1BC; IL1B convertase; IL1BCE; Interleukin 1 beta convertase; Interleukin 1 beta convertase precursor; Interleukin 1 beta converting enzyme; CASP-1; Interleukin-1 beta convertase; IL-1BC; Interleukin-1 beta-converting enzyme; ICE; IL-1 beta-converting enzyme; p45; CASP1_HUMAN; CASP1_MOUSE.	WB, ELISA, IHC-P, IHC-F, FC, ICC/IF	Human, Mouse, Rat,
	Caspase-1 Antibody is an unconjugated, approximately 46 kDa, rabbit-derived, anti-Caspase-1 polyclonal antibody. Caspase-1 Antibody can be used for: WB, ELISA, IHC-P, IHC-F, Flow-Cyt, ICC, IF expriments in human, mouse, rat, background without labeling.

HY-P84929

	IL1B Antibody (YA4626) IL-1; IL1F2; IL1beta; IL1-BETA	IHC-P, ICC/IF, FC, ELISA	Human

Compare Products


Products	In-stock - + Add to Cart
Cat. No.
Host
Reactivity
Application
Dilution Ratio
Molecular Weight
Conjugation
Clonality
Immunogen
Appearance
Isotype
Gene ID
SwissProt ID
Purity
Formulation
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Cat. No.	Product Name		Classification

HY-130252

YQ128 1 Publications Verification		Alkynes
YQ128 is a potent and selective second-generation NLRP3 (NOD-like receptor P3) inflammasome inhibitor with an IC₅₀ of 0.30 μM. YQ128 significantly and selectively suppresses the production of *IL-1β*, but not TNF-α, and it can cross the BBB to reach the CNS. YQ128 has anti-inflammatory activity ^[1]. YQ128 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-172451

MC4762		Alkynes
MC4762 is an inhibitor of NOX2 and MAOB, with IC₅₀ values of 0.155 μM and 0.182 μM, respectively. MC4762 has anti-inflammatory activity, can inhibit the production of ROS, and downregulate the expression of pro-inflammatory cytokines iNOS, *IL-1β, and IL-6* ^[1].

HY-173115

15-LOX-IN-2		Alkynes
15-LOX-IN-2 (Compound 2a) is an orally active COX-2/15-LOX inhibitor and a partial agonist of PPARγ. 15-LOX-IN-2 has anti-inflammatory activity and inhibits the levels of 20-HETE, *IL-1β* and TNF-α in RAW 264.7 cells treated with LPS (HY-D1056). In addition, 15-LOX-IN-2 has significant glucose uptake capacity in the absence of insulin. 15-LOX-IN-2 can be used for the research of metabolic diseases ^[1].

Cat. No.	Product Name		Classification

HY-100557

Hydroxypropyl Cellulose		Emulsifiers Thickeners
Hydroxypropyl Cellulose is an orally active cellulose ether and surfactant. Hydroxypropyl cellulose is divided into high-substituted HPC (HHPC) and low-substituted HPC (LHPC). Hydroxypropyl Cellulose reduces inflammatory mediators (IL-6, *IL-1β*). Hydroxypropyl Cellulose improves colitis and obesity. Hydroxypropyl Cellulose can be used as a pharmaceutical excipient, such as coating agent, emulsifier, suspension, tablet, thickener, viscosifier ^[1] .

HY-132591

Inclisiran 2 Publications Verification ALN-PCSsc		siRNAs siRNA drugs
Inclisiran is a double-stranded small interfering RNA (siRNA) molecule. Inclisiran inhibits the transcription of PCSK9. Inclisiran inhibits Pyroptosis, activates PPARγ, and reduces NLRP3, cleaved caspase-1, *IL-1β, and IL-18*. Inclisiran has anti-inflammatory, lipid-regulating and anti-atherosclerotic activities. Inclisiran can be used in researches of hyperlipidemia and cardiovascular disease (CVD) ^[1] .

HY-132591A

Inclisiran sodium 2 Publications Verification ALN-PCSsc sodium		siRNAs siRNA drugs
Inclisiran sodium is a double-stranded small interfering RNA (siRNA) molecule. Inclisiran sodium inhibits the transcription of PCSK9. Inclisiran sodium inhibits Pyroptosis, activates PPARγ, and reduces NLRP3, cleaved caspase-1, *IL-1β, and IL-18*. Inclisiran sodium has anti-inflammatory, lipid-regulating and anti-atherosclerotic activities. Inclisiran sodium can be used in researches of hyperlipidemia and cardiovascular disease (CVD) ^[1] .

HY-154629

Sesame Oil 1 Publications Verification		Solvents
Sesame Oil is a vegetable oil. Sesame Oil can be extracted from the seeds of Sesamum indicum L. Sesame Oil decreases NF-κB, aspartate aminotransferase, alanine aminotransferase, *IL-1β, IL-4* and nitric oxide. Sesame Oil has antitumor activity against malignant melanoma. Sesame Oil has protective effects against liver damage caused by various agents such as Cisplatin (HY-17394) and Acetaminophen (HY-66005). Sesame Oil shows antinociceptive and anti-inflammatory activities ^[1] .

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

IL-1beta

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Peptides

MCE Kits

Inhibitory Antibodies

NaturalProducts

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oligonucleotides

Natural
Products