2. Metabolic Enzyme/Protease Epigenetics Immunology/Inflammation Apoptosis Vitamin D Related/Nuclear Receptor Cell Cycle/DNA Damage
  3. PCSK9 Small Interfering RNA (siRNA) Pyroptosis PPAR NOD-like Receptor (NLR) Caspase Interleukin Related
  4. Inclisiran sodium

Inclisiran sodium  (Synonyms: ALN-PCSsc sodium)

Cat. No.: HY-132591A Purity: 98.91%
COA
SDS
Handling Instructions Technical Support

Inclisiran sodium is a double-stranded small interfering RNA (siRNA) molecule. Inclisiran sodium inhibits the transcription of PCSK9. Inclisiran sodium inhibits Pyroptosis, activates PPARγ, and reduces NLRP3, cleaved caspase-1, IL-1β, and IL-18. Inclisiran sodium has anti-inflammatory, lipid-regulating and anti-atherosclerotic activities. Inclisiran sodium can be used in researches of hyperlipidemia and cardiovascular disease (CVD).

For research use only. We do not sell to patients.

RNA, (Am-sp-(2'-deoxy-2'-fluoro)C-sp-Am-(2'-deoxy-2'-fluoro)A-(2'-deoxy-2'- fluoro)A-(2'-deoxy-2'-fluoro)A-Gm-(2'-deoxy-2'-fluoro)C-Am-(2'-deoxy-2'-fluoro)AAm-(2'-deoxy-2'-fluoro)A-Cm-(2'-deoxy-2'-fluoro)A-Gm-(2'-deoxy-2'-fluoro)G-Um-(2'-deoxy-2'-fluoro)C-Um-Am-Gm-sp-Am-sp-Am), complex with RNA (Cm-sp-Umsp -Am-Gm-Am-Cm-(2'-deoxy-2'-fluoro)C-Um-(2'-deoxy-2'-fluoro)G-Um-dT-UmUm-Gm-Cm-Um-Um-Um-Um-Gm-Um) 3'-[[(2S,4R)-1-[29-[[2-(acetylamino)-2- deoxy-β-D-galactopyranosyl]oxy]-14,14-bis[[3-[[3-[[5-[[2-(acetylamino)-2-deoxy-βD-galactopyranosyl]oxy]-1-oxopentyl]amino]propyl]amino]-3-oxopropoxy]methyl]- 1,12,19,25-tetraoxo-16-oxa-13,20,24-triazanonacos-1-yl]-4-hydroxy-2- pyrrolidinyl]methyl hydrogen phosphate] (1:1), sodium salt

Inclisiran sodium Chemical Structure

Size Price Stock Quantity
1 mg In-stock
5 mg In-stock
10 mg   Get quote  
50 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 4 publication(s) in Google Scholar

Other Forms of Inclisiran sodium:

Inclisiran sodium Related Antibodies

Top Publications Citing Use of Products

View All PPAR Isoform Specific Products:

View All Isoforms
PPARα PPARβ/δ PPARγ PPAR PPARδ

View All NOD-like Receptor (NLR) Isoform Specific Products:

View All Isoforms
NLRP3 NLRP1 NOD1 NOD2

View All Caspase Isoform Specific Products:

View All Isoforms
Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

View All Interleukin Related Isoform Specific Products:

View All Isoforms
IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Inclisiran sodium is a double-stranded small interfering RNA (siRNA) molecule. Inclisiran sodium inhibits the transcription of PCSK9. Inclisiran sodium inhibits Pyroptosis, activates PPARγ, and reduces NLRP3, cleaved caspase-1, IL-1β, and IL-18. Inclisiran sodium has anti-inflammatory, lipid-regulating and anti-atherosclerotic activities. Inclisiran sodium can be used in researches of hyperlipidemia and cardiovascular disease (CVD)[1][2][3].

IC50 & Target[1][2][3]

PPARγ

 

NLRP3

 

Caspase-1

 

IL-1β

 

In Vitro

Inclisiran (50-200 nM; 48 h) sodium significantly inhibits cell death, cytotoxicity, and downregulates mRNA and protein expressions of pyroptosis-related factors in ox-LDL-induced HUVECs[2].
Inclisiran (50-200 nM; 48 h) sodium inhibits ox-LDL-induced foam cell formation in Raw264.7 macrophages by activating the PPARγ pathway[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Inclisiran sodium Related Antibodies

Western Blot Analysis[2]

Cell Line: Human umbilical vein endothelial cells (HUVECs) treated with 25 μg/mL ox-LDL
Concentration: 50 nM, 100 nM, 200 nM
Incubation Time: 48 h
Result: Decreased the protein expression of NLRP3, ASC, cleaved caspase-1, GSDMD-N, IL-1β, and IL-18.

Western Blot Analysis[3]

Cell Line: Raw264.7 macrophages treated with ox-LDL
Concentration: 50 nM, 100 nM, 200 nM
Incubation Time: 48 h
Result: Increased PPARγ, SR-B1, ApoE, ABCA1.
Decreased SR-A, LOX-1, CD36.
In Vivo

Inclisiran (1-10 mg/kg; i.p.; 20 weeks) sodium inhibits the development of atherosclerosis and pyroptosis-related factor expression in high-fat diet-induced atherosclerotic ApoE-/- mice[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male ApoE-/- mice (8 weeks old, 17-20 g); high-fat diet (HFD)-induced atherosclerosis model[2]
Dosage: 1, 5, 10 mg/kg (dissolved in PBS)
Administration: Intraperitoneal injection; 20 weeks
Result: Significantly reduced LDL-C, TC, TG, and increased HDL-C in plasma.
Decreased aortic plaque area and lipid deposition.
Decreased pyroptosis-related factors (NLRP3, ASC, GSDMD, IL-1β, IL-18).
Clinical Trial
Molecular Weight

16339.00

Formula

C529H707F12N176O316P43S6.xNa
Appearance

Solid

Color

White to light yellow

SMILES

[Inclisiran (sodium)]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Purity & Documentation

Purity: 98.91%

SDS (252 KB)

COA (248 KB) RP-HPLC (216 KB)

Handling Instructions (2659 KB)
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Inclisiran sodium Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

InclisiranALN-PCSscPCSK9Small Interfering RNA (siRNA)PyroptosisPPARNOD-like Receptor (NLR)CaspaseInterleukin RelatedProprotein convertase subtilisin/kexin type 9Peroxisome proliferator-activated receptorsILsiRNAhyperlipidemiacardiovasculardiseaseLDL-CatheroscleroticmiceHUVECRaw264.7Inhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Inclisiran sodium
Cat. No.:
HY-132591A
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

English - EN (252 KB) Français - FR (252 KB) Deutsch - DE (252 KB) Norwegian - NO (252 KB) Español - ES (252 KB) Swedish - SV (252 KB) Italian - IT (252 KB) Portuguese - PT (252 KB)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.