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Humanly relevant dose

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841

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15

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Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-W087892
    Barium diphenylamine-4-sulfonate

    		Biochemical Assay Reagents Others
    Barium diphenylamine-4-sulfonate can be employed as an intermediate in pharmaceutical manufacturing and in chemical research, and serves as a dosing agent in analytical testing .
    Barium diphenylamine-4-sulfonate
  • HY-N2026R
    Propylparaben (Standard)

    Propyl parahydroxybenzoate (Standard); Propyl 4-hydroxybenzoate (Standard)

    		 Reference Standards Endogenous Metabolite Bacterial Apoptosis Infection
    Propylparaben (Standard) is the analytical standard of Propylparaben. This product is intended for research and analytical applications. Propylparaben (Propyl parahydroxybenzoate) is an antibacterial preservative that can be produced by plants and bacteria. Propylparaben is commonly used in cosmetics, pharmaceuticals and foods. Propylparaben disrupts follicular growth and steroidogenic function by altering cell cycle, apoptosis and steroidogenic pathways. Propylparaben also reduced sperm count and motility in rats .
    Propylparaben (Standard)
  • HY-N2026
    Propylparaben

    Propyl parahydroxybenzoate; Propyl 4-hydroxybenzoate

    		 Endogenous Metabolite Bacterial Apoptosis Infection
    Propylparaben (Propyl parahydroxybenzoate) is an antibacterial preservative that can be produced by plants and bacteria. Propylparaben is commonly used in cosmetics, pharmaceuticals and foods. Propylparaben disrupts follicular growth and steroidogenic function by altering cell cycle, apoptosis and steroidogenic pathways. Propylparaben also reduced sperm count and motility in rats .
    Propylparaben
  • HY-P2026
    A 71915

    		Natriuretic Peptide Receptor (NPR) Cardiovascular Disease
    A 71915 is a highly potent and competitive natriuretic peptide receptor A (ANP, NPRA) antagonist (pKi= 9.18). A 71915 displaces [ 125I]ANP dose dependently, with a Ki of 0.65 nM. A71915( pA2= 9.48) against rat ANP-induced cGMP production in NB-OK-1 cells .
    A 71915
  • HY-107787A
    Dioxopromethazine hydrochloride

    Prothanon hydrochloride; 9,9-Dioxopromethazine hydrochloride; 9,9-Dioxypromethazin hydrochloride

    		 Histamine Receptor Inflammation/Immunology
    Dioxopromethazine is an orally active antihistamine. Dioxopromethazine inhibits asthmatic symptoms and can be used for relevant research .
    Dioxopromethazine hydrochloride
  • HY-W087892R
    Barium diphenylamine-4-sulfonate (Standard)

    		Reference Standards Biochemical Assay Reagents Others
    Barium diphenylamine-4-sulfonate (Standard) is the analytical standard of Barium diphenylamine-4-sulfonate. This product is intended for research and analytical applications. Barium diphenylamine-4-sulfonate can be employed as an intermediate in pharmaceutical manufacturing and in chemical research, and serves as a dosing agent in analytical testing .
    Barium diphenylamine-4-sulfonate (Standard)
  • HY-118683
    KR-31378

    		Potassium Channel Others
    KR-31378 is a neuroprotectant with dose-dependent pharmacokinetic properties and relevant activity in rats. After intravenous and oral administration of KR-31378 in rats, its pharmacokinetic parameters showed dose-dependent changes, such as decreased clearance with increasing doses, good oral absorption, and comparable AUCs for intravenous and oral administration at different doses.
    KR-31378
  • HY-167659
    Isomylamine hydrochloride

    		Biochemical Assay Reagents Neurological Disease
    Isomylamine hydrochloride is a spasmolytic and smooth muscle relaxant that can be utilized in relevant research or chemical synthesis .
    Isomylamine hydrochloride
  • HY-145349
    FXIa-IN-6

    		Factor Xa Cardiovascular Disease
    FXIa-IN-6 is a potent FXIa inhibitor with selectivity against most of the relevant serine proteases (Ki = 0.3 nM).
    FXIa-IN-6
  • HY-P3012
    Cathepsin G

    		Cathepsin Inflammation/Immunology
    Cathepsin G acts as a potent agonist of human platelet activation leading to their aggregation., and can be used for screening of relevant inhibitors .
    Cathepsin G
  • HY-N12739
    Sibiriquinone A

    		Others Others
    Sibiriquinone A is a diterpene which can be extracted from Veronicastrum sibiricum. Sibiriquinone A exerts immunosuppressive activity and can be used for relevant researches .
    Sibiriquinone A
  • HY-400708
    (R)-Benzyl 2-cyclopropyl-2-hydroxyacetate

    		ADC Payload Cancer
    (R)-Benzyl 2-cyclopropyl-2-hydroxyacetate can be used in the synthesis of pyrrolidines, a relevant molecule for ADC applications .
    (R)-Benzyl 2-cyclopropyl-2-hydroxyacetate
  • HY-W725190A
    Piperidylthiambutene

    		Opioid Receptor Neurological Disease
    Piperidylthiambutene is a potent µ-opioid receptor (MOR) agonist with a Ki of 2.75 nM. Piperidylthiambutene exhibits analgesic and antitussive properties and can be utilized in relevant research .
    Piperidylthiambutene
  • HY-N15271
    Oxopurpureine

    		Thrombin Platelet-activating Factor Receptor (PAFR) Cardiovascular Disease
    Oxopurpureine is an oxoaporphine with antiplatelet aggregation activity. Oxopurpureine inhibits collagen, thrombin and arachidonic acid-induced platelet aggregation and can be utilized in relevant research .
    Oxopurpureine
  • HY-N14922
    Nikkomycin Lx

    		Antibiotic Bacterial Infection
    Nikkomycin Lx is an antibiotic that can be extracted from Streptomyces tendae TU901. Nikkomycin Lx exhibits anti-Candida Albicans activity and can be utilized in relevant research .
    Nikkomycin Lx
  • HY-167698
    Dibenamine

    		Histamine Receptor Adrenergic Receptor Inflammation/Immunology
    Dibenamine is an alpha-adrenergic antagonist that exhibits the ability to block both basal and histamine-stimulated gastric acid secretion, making it therapeutically relevant in conditions involving excessive gastric acid production.
    Dibenamine
  • HY-107787AR
    Dioxopromethazine hydrochloride (Standard)

    Prothanon hydrochloride (Standard); 9,9-Dioxopromethazine hydrochloride (Standard); 9,9-Dioxypromethazin hydrochloride (Standard)

    		 Reference Standards Histamine Receptor Inflammation/Immunology
    Dioxopromethazine hydrochloride (Standard) is the analytical standard of Dioxopromethazine hydrochloride. This product is intended for research and analytical applications. Dioxopromethazine is an orally active antihistamine. Dioxopromethazine inhibits asthmatic symptoms and can be used for relevant research .
    Dioxopromethazine hydrochloride (Standard)
  • HY-D2188
    IMP-2373

    		Fluorescent Dye Deubiquitinase Cancer
    IMP-2373 is the activity-based probe (ABP). IMP-2373 is a covalent pan- deubiquitinase(DUB) ABP to monitor DUB activity in physiologically relevant live cells .
    IMP-2373
  • HY-N7402
    Hexyl hexanoate

    		Others Others
    Hexyl hexanoate is a fruit aroma component with potential food and beverage additive activity. Hexyl hexanoate is found in alcoholic beverages and is used to blend fruit flavors. Hexyl hexanoate is present in many fruits, Parmesan cheese, alcoholic beverages, and black tea. Hexyl hexanoate is a volatile component produced as a result of fruit ripening. Toxicity assessments of hexyl hexanoate showed that it is not mutagenic and that exposure is below safety thresholds for repeated dose, reproduction, and local respiratory toxicity. Hexyl hexanoate is also below thresholds in skin sensitization assessments, and for phototoxicity and photosensitization, the results showed that it does not present a relevant risk. Hexyl hexanoate is considered non-persistent, non-bioaccumulative, and non-toxic according to the environmental criteria of the International Fragrance Association .
    Hexyl hexanoate
  • HY-117867A
    AVE-8063 hydrochloride

    AC-7739

    		 Endogenous Metabolite Inflammation/Immunology
    AVE-8063 (AC-7739) hydrochloride is a therapeutic agent associated with the modulation of inflammatory responses in inflammatory bowel disease (IBD), displaying mechanisms that may be relevant for precision targeting in current therapies.
    AVE-8063 hydrochloride
  • HY-105955
    FPL 14294

    ARL 14294

    		 Cholecystokinin Receptor Metabolic Disease
    FPL 14294 is a intranasally active anorectic agent and a cholecystokinin octapeptide (CCK) analog with enhanced metabolic stability. FPL 14294 induces satiety in many species and can be utilized in relevant research .
    FPL 14294
  • HY-139802
    L-779976

    		Somatostatin Receptor Others
    L-779976 is a compound with bradykinin agonist activity. Injection into the amygdala and septum of the rat brain can produce anxiolytic effects. Its bradykinin agonist activity has been verified by relevant experiments.
    L-779976
  • HY-P991140
    Garetatug

    		Claudin Cancer
    Garetatug is a humanized monoclonal antibody targeting human CLDN18 (claudin-18). Garetatug specifically binds to CLDN18, interfering with relevant cell signaling pathways and exerting antitumor activity .
    Garetatug
  • HY-110065
    SER-601

    		Cannabinoid Receptor Neurological Disease
    SER-601 is a potent and selective peripheral cannabinoid (CB2) receptor agonist with a Ki of 6.3 nM. SER-601 has analgesic and antidiabetic properties and can be used for relevant research .
    SER-601
  • HY-B1776
    Spermidine
    5+ Cited Publications

    		 Endogenous Metabolite Metabolic Disease
    Spermidine maintains cell membrane stability, increases antioxidant enzymes activities, improving photosystem II (PSII), and relevant gene expression. Spermidine significantly decreases the H2O2 and O2 .- contents .
    Spermidine
  • HY-155711
    Antifungal agent 69

    		Fungal Infection
    Antifungal agent 69 (compound 13) is a eugenol-imidazole against Candida albicans (MIC: 4.6 μM) with no relevant cytotoxicity. Antifungal agent 69 alters the fungal ergosterol biosynthesis and shows antifungal activity .
    Antifungal agent 69
  • HY-136654
    LPK-26 hydrochloride

    		Opioid Receptor Neurological Disease
    LPK-26 hydrochloride is a selective kappa-opioid receptor agonist with a Ki of 0.68 nM. LPK-26 exhibits potent antinociceptive effects with low physical dependence potential and can be utilized in relevant research .
    LPK-26 hydrochloride
  • HY-B1776A
    Spermidine hydrochloride
    5+ Cited Publications

    		 Endogenous Metabolite Metabolic Disease
    Spermidine hydrochloride maintains cell membrane stability, increases antioxidant enzymes activities, improving photosystem II (PSII), and relevant gene expression. Spermidine hydrochloride significantly decreases the H2O2 and O2 .- contents .
    Spermidine hydrochloride
  • HY-143419
    ATX inhibitor 14

    		Phosphodiesterase (PDE) Inflammation/Immunology
    ATX inhibitor 14 (compound 4), a indole-based carbamate derivative, is a potent autotaxin (ATX) inhibitor with an IC50 of 0.41 nM. ATX inhibitor 14 has the potential for fibrosis relevant diseases research .
    ATX inhibitor 14
  • HY-W243303O
    Poly(acrylic acid) (MW 1250000) (viscous liquid)

    		Biochemical Assay Reagents Cancer
    Poly(acrylic acid) (Mv 1250000) (viscous liquid) is an anionic polymer with a molecular weight of 1,250,000. It can be used as a corrosion inhibitor and surface stabilizer, as well as a biomaterial or organic compound relevant to life sciences research .
    Poly(acrylic acid) (MW 1250000) (viscous liquid)
  • HY-163316
    SIRT4-IN-1
    2 Publications Verification

    		 Sirtuin Metabolic Disease Cancer
    SIRT4-IN-1 (compound 69) is selective sirtuin 4 (Sirt4) inhibitor with an IC50 of 16 μM.SIRT4-IN-1 shows no relevant effects on other sirtuin isoforms .
    SIRT4-IN-1
  • HY-120298
    LY-510929

    		PPAR Others
    LY-510929 is a compound that induces left ventricular hypertrophy (LVH). Related studies have identified the relevant conditions in which LY-510929 may induce LVH by measuring multiple markers and using multiple techniques.
    LY-510929
  • HY-115844
    LY-99335

    		Opioid Receptor Endogenous Metabolite Neurological Disease
    LY-99335 is an anesthetic antagonist with behavioral inhibitory activity. LY-99335 exhibits large dose separation at specific doses, indicating its potential in anesthetic antagonism .
    LY-99335
  • HY-136676
    Cgp 38560 methanesulfonate

    		Renin Cancer
    Cgp 38560 methanesulfonate is a well-tolerated renin inhibitor. Cgp 38560 methanesulfonate caused a dose-dependent decrease in angiotensin II and plasma renin activity, and a dose-dependent increase in active renin.
    Cgp 38560 methanesulfonate
  • HY-P4127A
    M65 TFA

    		PACAP Receptor Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
    M65 TFA is a deleted peptide of maxadilan (61 a.a.) with deletion of the residues between positions 24 and 42 and is a specific antagonist of PACAP type 1 receptor that inhibits ANP secretion and can be used for relevant researches .
    M65 TFA
  • HY-W134402
    Osmium(III) chloride hydrate

    		Biochemical Assay Reagents
    Osmium(III) chloride hydrate is an inorganic compound with catalytic and synthetic activity. Osmium(III) chloride hydrate can be used as a catalyst in organic synthesis reactions to promote the reaction. Osmium(III) chloride hydrate can be used as a high-purity salt in material science to provide relevant chemical properties.
    Osmium(III) chloride hydrate
  • HY-P991143
    Ixotatug

    		Claudin Cancer
    Ixotatug is a monoclonal antibody targeting human CLDN6 (claudin-6). Ixotatug specifically binds to CLDN6, interfering with relevant signaling pathways in tumor cells and exerting antitumor activity. Ixotatug is promising for research of cancers .
    Ixotatug
  • HY-129737
    A-62198

    		Endogenous Metabolite Cardiovascular Disease
    A-62198 is a potent and selective renin inhibitor with antihypertensive activity. A-62198 reduces mean arterial pressure (MAP) in anesthetized, salt-deprived monkeys in a dose-dependent manner. A-62198 induced MAP reduction in normal monkeys that reached statistical significance at the highest dose and significantly inhibited plasma renin activity (PRA) at all doses .
    A-62198
  • HY-13714
    Nolatrexed

    AG 337 free base

    		 Antifolate Others
    Nolatrexed (AG 337 free base) is a compound with antifolate activity, high oral bioavailability, and major toxicity at inhibitory doses is gastrointestinal reactions. It can be safely taken orally at specific doses for inhibition, with effects on platelets and neutrophils.
    Nolatrexed
  • HY-P991125
    Cenzestotug

    YH-002

    		 TNF Receptor Inflammation/Immunology Cancer
    Cenzestotug is a monoclonal antibody targeting human tumor necrosis factor receptor superfamily member 4 (TNFRSF4). Cenzestotug activates relevant immune cells by binding to TNFRSF4, exerting immunostimulatory and antitumor activities. Cenzestotug is promising for research of cancer immunotherapy .
    Cenzestotug
  • HY-P991156
    Rapaprutug

    		Ras Inflammation/Immunology
    Rapaprutug is a monoclonal antibody targeting human KARS1 (lysyl-tRNA synthetase 1). Rapaprutug blocks the relevant inflammatory signaling pathways in which KARS1 is involved, reducing the production and release of inflammatory factors. Rapaprutug is promising for research of inflammatory diseases .
    Rapaprutug
  • HY-101434A
    Cetamolol hydrochloride

    AI-27303 hydrochloride; ICI-72222 hydrochloride

    		 Adrenergic Receptor Others
    Cetamolol hydrochloride is classified as a potent β1-blocker with intrinsic sympathomimetic activity and cardioselectivity. Low and medium doses of Cetamolol and Atenolol produce a more prolonged inhibitory effect than the same doses of Propranolol and Dexpropranolol.
    Cetamolol hydrochloride
  • HY-W011180
    Vitamin A Propionate

    		Drug Derivative Others
    Vitamin A Propionate is an ester compound of vitamin A. In nutritional studies of foals, different doses have different effects on growth, serum biochemistry and hematological indicators. Too high or too low doses will produce adverse effects and are related to the vitamin A concentration in plasma, liver and kidneys.
    Vitamin A Propionate
  • HY-P1851
    AGA-(C8R) HNG17, humanin derivative

    		Amino Acid Derivatives Neurological Disease
    AGA-(C8R) HNG17, Humanin derivative is a potent humanin (HN) derivative. AGA-(C8R) HNG17, Humanin derivative completely suppresses neuronal cell death by Alzheimer's disease-relevant insults .
    AGA-(C8R) HNG17, humanin derivative
  • HY-W037976
    Tyrosinase-IN-22

    5-Chloro-2-mercaptobenzimidazole

    		 Reactive Oxygen Species (ROS) Tyrosinase Cancer
    Tyrosinase-IN-22 (compound 4) is an inhibitor of tyrosinase substrates (L-tyrosine and L-dopa) with IC50s of 60 nM and 30 nM, respectively. Tyrosinase-IN-22 also shows potent antioxidant and anti-melanogenic properties, thus can be used for relevant researches .
    Tyrosinase-IN-22
  • HY-B1776S
    Spermidine-d6

    		Endogenous Metabolite Metabolic Disease
    Spermidine-d6 is the deuterium labeled Spermidine . Spermidine maintains cell membrane stability, increases antioxidant enzymes activities, improving photosystem II (PSII), and relevant gene expression. Spermidine significantly decreases the H2O2 and O2.- contents .
    Spermidine-d6
  • HY-P1851A
    AGA-(C8R) HNG17, humanin derivative TFA

    		Amino Acid Derivatives Neurological Disease
    AGA-(C8R) HNG17, humanin derivative TFA is a potent humanin (HN) derivative. AGA-(C8R) HNG17, humanin derivative completely suppresses neuronal cell death by Alzheimer's disease-relevant insults .
    AGA-(C8R) HNG17, humanin derivative TFA
  • HY-113648
    LP10

    		HBV Infection
    LP10 is a non-azole CYP51 inhibitor with activity against Trypanosoma cruzi infection. Treatment with LP10 blocks the 14α-demethylation step, leading to disruption of the parasite cell membrane and ultimately triggering the death of important clinically relevant amoeba stages .
    LP10
  • HY-142052
    Anhydrotetracycline

    5a(6)-Anhydrotetracycline

    		 Antibiotic Infection
    Anhydrotetracycline shows dose-dependent and potent inhibition of tetracycline destructases in vitro .
    Anhydrotetracycline
  • HY-B1776AS1
    Spermidine-13C4 hydrochloride
    1 Publications Verification

    		 Isotope-Labeled Compounds Endogenous Metabolite Metabolic Disease
    Spermidine- 13C4 (hydrochloride) is the 13C-labeled Spermidine trihydrochloride. Spermidine hydrochloride maintains cell membrane stability, increases antioxidant enzymes activities, improving photosystem II (PSII), and relevant gene expression. Spermidine hydrochloride significantly decreases the H2O2 and O2.- contents .
    Spermidine-13C4 hydrochloride

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