Betamethasone acetate

Name: Betamethasone acetate
Brand: MedChemExpress
SKU: HY-13570B
Rating: 4.5 (1 reviews)

Cat. No.: HY-13570B Purity: 99.38%: Data Sheet
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Betamethasone acetate is a glucocorticoid with prenatal application for preventing respiratory distress syndrome (RDS) in premature infants. Betamethasone acetate exhibits dose-dependent effects on somatic and brain development in offspring when administered prenatally to pregnant rats. Betamethasone acetate can be used for the study of antenatal intervention.

For research use only. We do not sell to patients.

Betamethasone acetate Chemical Structure

CAS No. : 987-24-6

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

Other Forms of Betamethasone acetate:

Betamethasone In-stock
Betamethasone disodium phosphate In-stock
Betamethasone hydrochloride Get quote
Betamethasone acetate-d₅ Get quote
Betamethasone acetate (Standard) Get quote

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Biological Activity
Purity & Documentation
References
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Description

Cellular Effect

Cell Line	Type	Value	Description	References
HepG2	EC₅₀	4.5 μM Compound: Dexamethasone acetate	Activation of rat PXR expressed in human HepG2 cells after 24 hrs by luciferase reporter gene based luminescent analysis Activation of rat PXR expressed in human HepG2 cells after 24 hrs by luciferase reporter gene based luminescent analysis	[PMID: 20966043]

In Vivo

Betamethasone acetate (0.125-0.25 mg/kg, i.m., single dose) improves fetal lung maturation in preterm sheep^[1].
Betamethasone (170-340 μg/ kg, i.n., twice within 4 h on E20) (acetate) induces moderate dose-dependent somatic growth retardation (reduced birth weight, crown-tail length, head diameter) in offspring of pregnant Fisher 344 rats^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Preterm sheep (122 days of gestation)^[1]
Dosage:	0.125, 0.25 mg/kg
Administration:	i.m., single dose
Result:	Improved fetal lung maturation in preterm sheep. Increased the mRNA expression of surfactant proteins A, B, C (SFTPA, SFTPB, SFTPC), ABCA3, and AQP5 in fetal sheep lungs.

Animal Model:	3-month-old time-pregnant Fisher 344 dams^[2]
Dosage:	170, 340 μg/ kg
Administration:	i.n., twice within 4 h on E20
Result:	Induced moderate dose-dependent somatic growth retardation. Caused significant brain growth retardation in offspring. Exhibited chronically anti-proliferative effects on brain cells.

Molecular Weight

434.50

Formula

C₂₄H₃₁FO₆

CAS No.

987-24-6

Appearance

Solid

Color

White to off-white

SMILES

C[C@@]12[C@](C[C@H](C)[C@]2(O)C(COC(C)=O)=O)([H])[C@]3([H])CCC4=CC(C=C[C@]4(C)[C@@]3(F)[C@@H](O)C1)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Purity & Documentation

Purity: 99.38%

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Data Sheet (278 KB) SDS (393 KB)

COA (260 KB)

Handling Instructions (2659 KB)

References

[1]. Schmidt AF, et al. Low-dose betamethasone-acetate for fetal lung maturation in preterm sheep. Am J Obstet Gynecol. 2018 Jan;218(1):132.e1-132.e9. [Content Brief]

[2]. Scheepens A, et al. A single course of prenatal betamethasone in the rat alters postnatal brain cell proliferation but not apoptosis. J Physiol. 2003 Oct 1;552(Pt 1):163-75. [Content Brief]