2. Membrane Transporter/Ion Channel
  3. Chloride Channel
  4. (2-Aminophenyl)methanol

(2-Aminophenyl)methanol  (Synonyms: 2-Hydroxymethylaniline)

Cat. No.: HY-W004705 Purity: 99.82%
COA
SDS
Handling Instructions Technical Support

(2-Aminophenyl)methanol (2-Hydroxymethylaniline) is a molecular chaperone to rescue P123S mutant pendrin. (2-Aminophenyl)methanol has the advantages of low dose, long-term effect and low toxicity. (2-Aminophenyl)methanol can be used for the study of Pendred syndrome (a syndromic deafness) .

For research use only. We do not sell to patients.

(2-Aminophenyl)methanol

(2-Aminophenyl)methanol Chemical Structure

CAS No. : 5344-90-1

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25 g In-stock
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Based on 1 publication(s) in Google Scholar

(2-Aminophenyl)methanol Related Antibodies

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Description

(2-Aminophenyl)methanol (2-Hydroxymethylaniline) is a molecular chaperone to rescue P123S mutant pendrin. (2-Aminophenyl)methanol has the advantages of low dose, long-term effect and low toxicity. (2-Aminophenyl)methanol can be used for the study of Pendred syndrome (a syndromic deafness) [1].

Cellular Effect
Cell Line Type Value Description References
HEK293 IC50
3.6 mM
Compound: 8
Cytotoxicity against HEK293 cells harboring pendrin P123S mutant after 72 hrs by MTT assay
Cytotoxicity against HEK293 cells harboring pendrin P123S mutant after 72 hrs by MTT assay
[PMID: 28341401]
In Vitro

(2-Aminophenyl)methanol (0.03-1 mM, 12 h) achieves significant rescue in HEK293 cells at 0.1 mM and maintains long-lasting efficacy after removal[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(2-Aminophenyl)methanol Related Antibodies
Molecular Weight

123.16

Formula

C7H9NO
CAS No.
Appearance

Solid

Color

Off-white to light brown

SMILES

OCC1=CC=CC=C1N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (811.95 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 8.1195 mL 40.5976 mL 81.1952 mL
5 mM 1.6239 mL 8.1195 mL 16.2390 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.82%

SDS (393 KB)

COA (250 KB) HNMR (129 KB) RP-HPLC (225 KB) LCMS (100 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 8.1195 mL 40.5976 mL 81.1952 mL 202.9880 mL
5 mM 1.6239 mL 8.1195 mL 16.2390 mL 40.5976 mL
10 mM 0.8120 mL 4.0598 mL 8.1195 mL 20.2988 mL
15 mM 0.5413 mL 2.7065 mL 5.4130 mL 13.5325 mL
20 mM 0.4060 mL 2.0299 mL 4.0598 mL 10.1494 mL
25 mM 0.3248 mL 1.6239 mL 3.2478 mL 8.1195 mL
30 mM 0.2707 mL 1.3533 mL 2.7065 mL 6.7663 mL
40 mM 0.2030 mL 1.0149 mL 2.0299 mL 5.0747 mL
50 mM 0.1624 mL 0.8120 mL 1.6239 mL 4.0598 mL
60 mM 0.1353 mL 0.6766 mL 1.3533 mL 3.3831 mL
80 mM 0.1015 mL 0.5075 mL 1.0149 mL 2.5373 mL
100 mM 0.0812 mL 0.4060 mL 0.8120 mL 2.0299 mL
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(2-Aminophenyl)methanol Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(2-Aminophenyl)methanol5344-90-12-HydroxymethylanilineChloride ChannelCl− ChannelsHearing lossPendrinP123S mutantMisfoldingMolecular chaperoneLocalizationMorphological analysisInhibitorinhibitorinhibit

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SAFETY DATA SHEET (SDS)

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