Search Result

Results for "

caspase-1/3r

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Caspase (77) 5-HT Receptor (15) ADC Linker (4) Adenosine Receptor (7) AIM2 (2) Akt (8) Amino Acid Derivatives (16) Amylin Receptor (2) Angiotensin-converting Enzyme (ACE) (1) Antibiotic (8) Antifolate (1) AP-1 (2) Apoptosis (22) ATP Synthase (1) Autophagy (5) Bacterial (15) Bcl-2 Family (1) Biochemical Assay Reagents (95) Btk (1) c-Met/HGFR (2) Calcium Channel (8) Cathepsin (2) CDK (5) CGRP Receptor (1) Checkpoint Kinase (Chk) (1) Cholinesterase (ChE) (5) ClpP (1) COX (3) CRAC Channel (1) Cytochrome P450 (4) Disulfidptosis (1) DNA/RNA Synthesis (5) Dopamine Receptor (22) Drug Derivative (6) Drug Intermediate (27) Drug Isomer (5) Drug Metabolite (13) E3 Ligase Ligand-Linker Conjugates (8) EGFR (1) Endogenous Metabolite (24) Epigenetic Reader Domain (2) ERK (2) Estrogen Receptor/ERR (1) Farnesyl Transferase (1) Ferroptosis (7) FKBP (1) FLT3 (1) Fluorescent Dye (5) Fungal (2) GABA Receptor (2) Glutathione Peroxidase (3) GPR109A (1) GPR55 (2) GSK-3 (1) HCV (2) HDAC (1) Hedgehog (1) Heme Oxygenase (HO) (3) HIF/HIF Prolyl-Hydroxylase (1) Histamine Receptor (34) Histone Methyltransferase (3) HIV (3) HMG-CoA Reductase (HMGCR) (5) IFNAR (2) iGluR (1) IKZF Family (1) Influenza Virus (2) Insulin Receptor (2) Integrin (4) Interleukin Related (35) Isotope-Labeled Compounds (37) JAK (4) Keap1-Nrf2 (5) Lactate Dehydrogenase (1) Ligands for E3 Ligase (2) Liposome (2) LPL Receptor (2) mAChR (10) MAGL (1) MDM-2/p53 (1) MEK (1) Melanocortin Receptor (15) mGluR (5) MicroRNA (2) Microtubule/Tubulin (3) Mitochondrial Metabolism (1) Mitosis (4) Mixed Lineage Kinase (3) MMP (4) Molecular Glues (2) Monoamine Oxidase (4) Monoamine Transporter (2) nAChR (2) NADPH Oxidase (1) Necroptosis (5) NEKs (2) Neurokinin Receptor (11) NF-κB (7) NO Synthase (3) NOD-like Receptor (NLR) (28) Nuclear Factor of activated T Cells (NFAT) (2) Nucleoside Antimetabolite/Analog (10) Opioid Receptor (3) Orexin Receptor (OX Receptor) (1) P-glycoprotein (1) P2X Receptor (4) p38 MAPK (10) p62 (1) Parasite (2) PARP (2) PCSK9 (2) PERK (1) Phosphatase (2) Phospholipase (2) PI3K (8) Pim (1) PKA (1) Potassium Channel (6) PPAR (2) PROTAC Linkers (1) PROTACs (2) Pyroptosis (19) Ras (1) Reactive Oxygen Species (ROS) (9) Reference Standards (45) Reverse Transcriptase (1) RIP kinase (1) SARS-CoV (4) Sigma Receptor (3) Small Interfering RNA (siRNA) (24) Somatostatin Receptor (1) Tau Protein (2) Thyroid Hormone Receptor (2) TNF Receptor (6) Toll-like Receptor (TLR) (3) Topoisomerase (1) TRP Channel (3) Tyrosinase (3) VEGFR (1) Wnt (4) α-synuclein (1) β-catenin (4)
By Research Areas:	Cancer (99) Cardiovascular Disease (25) Endocrinology (20) Infection (29) Inflammation/Immunology (117) Metabolic Disease (95) Neurological Disease (114)
Click Chemistry:	Azide (12)
Oligonucleotides:	Adenosine (2) Nucleoside Phosphoramidites (2) Nucleoside Analogs (7) Adenine (1) Rat Pre-designed siRNA Sets (6) Inosine (1) Mouse Pre-designed siRNA Sets (6) siRNA drugs (2) Human Pre-designed siRNA Sets (10) Cytidine (2) Guanine (1) siRNAs (24)

609

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

MCE Kits

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oligonucleotides

Targets Recommended: Caspase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-16990

Ac-YVAD-cmk 25+ Cited Publications caspase-1 Inhibitor II	Caspase	Inflammation/Immunology
Ac-YVAD-cmk (Caspase-1 Inhibitor II) is a selective *caspase-1* (IL-1beta converting enzyme, ICE)) inhibitor with neuroprotective and anti-inflammatory effects. Ac-YVAD-cmk effectively suppresses the expression of IL-1β and IL-18. Ac-YVAD-cmk inhibits pyroptosis in many diseases ^[1] .

HY-130774

Ponceau 3R	Fluorescent Dye	Others
Ponceau 3R is an azo dye and can be used as a food colorant ^[1].

HY-CE00168A

(3R)-Hydroxyhexadecanedioyl-CoA (3r)-Hydroxyhexadecanedioyl-coenzyme A	Biochemical Assay Reagents	Others
(3R)-Hydroxyhexadecanedioyl-CoA ((3R)-Hydroxyhexadecanedioyl-coenzyme A) is an (R)-3-hydroxyacyl-CoA.

HY-CE00152

(3R)-Citramalyl-CoA (3r)-Citramalyl-coenzyme A	Biochemical Assay Reagents	Others
(3R)-Citramalyl-CoA ((3R)-Citramalyl-coenzyme A) is a derivative of Coenzyme A (HY-128851).

HY-CE00144

(3R)-3-Hydroxyoctanoyl-CoA (3r)-3-Hydroxyoctanoyl-coenzyme A	Biochemical Assay Reagents	Others
(3R)-3-Hydroxyoctanoyl-CoA ((3R)-3-Hydroxyoctanoyl-coenzyme A) is a derivative of Coenzyme A (HY-128851).

HY-12422C

rel-(2S,3R)-Voruciclib	CDK	Cancer
rel-(2S,3R)-Voruciclib is the (2S,3R)-enantiomer of Voruciclib. (2S,3R)-Voruciclib is an orally active CDK inhibitor ^[1].

HY-Z5058S

(3R,5S)-Fluvastatin-d7 sodium (3r,5S)-XU 62-320-d₇	Isotope-Labeled Compounds	Others
(3R,5S)-Fluvastatin-d₇ (sodium) is the deuterium labeled (3R,5S)-Fluvastatin sodium ^[1].

HY-W699829

(3R,5R)-Rosuvastatin Lactone-d6	Isotope-Labeled Compounds Drug Isomer	Cardiovascular Disease
(3R,5R)-Rosuvastatin Lactone-d₆ is the deuterium labeled (3R,5R)-Rosuvastatin Lactone (HY-135406). (3R,5R)-Rosuvastatin Lactone is an isomer of Rosuvastatin Lactone.

HY-CE00136

(3R)-3-Isopropenyl-6-oxoheptanoyl-CoA (3r)-3-Isopropenyl-6-oxoheptanoyl-coenzyme A	Biochemical Assay Reagents	Others
(3R)-3-Isopropenyl-6-oxoheptanoyl-CoA ((3R)-3-Isopropenyl-6-oxoheptanoyl-coenzyme A) is an unsaturated fatty acyl-CoA.

HY-CE00181

(3R,11Z)-3-hydroxyoctadecenoyl-CoA (3r,11Z)-3-hydroxyoctadecenoyl-coenzyme A	Biochemical Assay Reagents	Others
(3R,11Z)-3-hydroxyoctadecenoyl-CoA ((3R,11Z)-3-hydroxyoctadecenoyl-coenzyme A) is an unsaturated fatty acyl-CoA.

HY-CE00215

(3R,13Z)-3-Hydroxyicosenoyl-CoA (3r,13Z)-3-Hydroxyicosenoyl-coenzyme A	Biochemical Assay Reagents	Others
(3R,13Z)-3-Hydroxyicosenoyl-CoA ((3R,13Z)-3-Hydroxyicosenoyl-coenzyme A) is an unsaturated fatty acyl-CoA.

HY-CE00257

(3R,15Z)-3-Hydroxytetracosenoyl-CoA (3r,15Z)-3-Hydroxytetracosenoyl-coenzyme A	Biochemical Assay Reagents	Metabolic Disease
(3R,15Z)-3-Hydroxytetracosenoyl-CoA ((3R,15Z)-3-Hydroxytetracosenoyl-coenzyme A) is a 3-hydroxy fatty acyl-CoA.

HY-CE00179

(3R,11Z)-3-Hydroxyicosenoyl-CoA (3r,11Z)-3-Hydroxyicosenoyl-coenzyme A	Biochemical Assay Reagents	Others
(3R,11Z)-3-Hydroxyicosenoyl-CoA ((3R,11Z)-3-Hydroxyicosenoyl-coenzyme A) is a 3-hydroxy fatty acyl-CoA.

HY-CE00214

(3R,13Z)-3-Hydroxydocosenoyl-CoA (3r,13Z)-3-Hydroxydocosenoyl-coenzyme A	Biochemical Assay Reagents	Others
(3R,13Z)-3-Hydroxydocosenoyl-CoA ((3R,13Z)-3-Hydroxydocosenoyl-coenzyme A) is a 3-hydroxy fatty acyl-CoA.

HY-14664F

(3R,5S)-Fluvastatin sodium (3r,5S)-XU 62-320	HMG-CoA Reductase (HMGCR) Autophagy	Cancer
(3R,5S)-Fluvastatin ((3R,5S)-XU 62-320) sodium is the 3R,5S-isomer Fluvastatin. Fluvastatin (XU 62-320 free acid) is a first fully synthetic, competitive HMG-CoA reductase inhibitor with an IC50 of 8 nM. Fluvastatin protects vascular smooth muscle cells against oxidative stress through the Nrf2-dependent antioxidant pathway ^[1] ^[3].

HY-CE00133

(3R)-3-Carboxy-3-hydroxypropanoyl-CoA (R)-Malyl-coenzyme A	Biochemical Assay Reagents	Others
(3R)-3-Carboxy-3-hydroxypropanoyl-CoA ((R)-Malyl-coenzyme A) is a (3R)-3-hydroxyacyl-CoA.

HY-W006202

BOC-(1S,3R)-3-aminocyclopentanecarboxylic acid (1S,3r)-3-[(tert-Butoxycarbonyl)amino]cyclopentanecarboxylic acid	Drug Intermediate	Others
BOC-(1S,3R)-3-aminocyclopentanecarboxylic acid ((1S,3R)-3-[(tert-Butoxycarbonyl)amino]cyclopentanecarboxylic acid) is a synthetic intermediate useful for pharmaceutical synthesis.

HY-CE00132

(3R)-3,5-Dihydroxy-3-methylpentanoyl-CoA (3r)-3,5-Dihydroxy-3-methylpentanoyl-coenzyme A	Biochemical Assay Reagents	Others
(3R)-3,5-Dihydroxy-3-methylpentanoyl-CoA ((3R)-3,5-Dihydroxy-3-methylpentanoyl-coenzyme A) is a derivative of Coenzyme A (HY-128851).

HY-N8917

(3R)-7-hydroxy-3-(4-hydroxybenzyl)chromane	Phosphatase	Metabolic Disease
(3R)-7-hydroxy-3-(4-hydroxybenzyl)chromane is a homoisoflavonoid. (3R)-7-hydroxy-3-(4-hydroxybenzyl)chromane increases the level of alkaline phosphatase (ALP) activity. (3R)-7-hydroxy-3-(4-hydroxybenzyl)chromane promotes mesenchymal stem cells (MSCs) osteogenesis, but cannot enhance MSCs proliferation. (3R)-7-hydroxy-3-(4-hydroxybenzyl)chromane can be used for osteoporosis research ^[1].

HY-B0590B

(+)-Tetrabenazine (+)-TBZ; (3r,11bR)-TBZ; (3r,11bR)-Tetrabenazine	Monoamine Transporter	Cancer
(+)-Tetrabenazine ((+)-TBZ; (3R,11bR)-TBZ; (3R,11bR)-Tetrabenazine) is a reversible inhibitor of vesicular monoamine transporter 2 (VMAT-2), inhibits transport by VMAT2 with 10-fold greater potency than transport by VMAT1.

HY-12422E

rel-(2S,3R)-Voruciclib hydrochloride	CDK	Cancer
rel-(2S,3R)-Voruciclib hydrochloride is the rel-(2S,3R)-enantiomer of Voruciclib. Voruciclib is an orally active CDK inhibitor ^[1].

HY-133872

[(3R)-3-Hydroxydodecanoyl]-L-carnitine	Endogenous Metabolite	Others
[(3R)-3-Hydroxydodecanoyl]-L-carnitine is an endogenous metabolite ^[1].

HY-135406

(3R,5R)-Rosuvastatin Lactone	Drug Isomer	Cardiovascular Disease Metabolic Disease
(3R,5R)-Rosuvastatin Lactone is an isomer of Rosuvastatin Lactone.

HY-150092S

(2S,3R)-8(9)-EET-d11	Isotope-Labeled Compounds Drug Metabolite	Others
(2S,3R)-8(9)-EET-d₁₁ is deuterium-labeled (2S,3R)-8(9)-EET (HY-150092) ^[1].

HY-109022A

(3R,5R,6S)-Atogepant (3r,5R,6S)-MK-8031; (3r,5R,6S)-AGN-241689	CGRP Receptor	Neurological Disease
(3R,5R,6S)-Atogepant ((3R,5R,6S)-MK-8031) is the enantiomer of Atogepant (HY-109022). Atogepant is a calcitonin gene-related peptide receptor (CGRP) antagonist. Atogepant can be used for researching migraine.

HY-W012864S

(2S,3R)-2,3,4-Trihydroxybutanal-13C	Isotope-Labeled Compounds	Others
(2S,3R)-2,3,4-Trihydroxybutanal- ¹³C is the ¹³C labeled (2S,3R)-2,3,4-Trihydroxybutanal ^[1].

HY-CE00162

(2S,3R)-3-Fluoro-2-methylhexadecanoyl-CoA (2S,3r)-3-Fluoro-2-methylhexadecanoyl-coenzyme A	Biochemical Assay Reagents	Others
(2S,3R)-3-Fluoro-2-methylhexadecanoyl-CoA ((2S,3R)-3-Fluoro-2-methylhexadecanoyl-coenzyme A) is a derivative of Coenzyme A (HY-128851).

HY-CE00218

(2S,3R)-3-Hydroxy-2-methylpentanedioyl-CoA (2S,3r)-3-Hydroxy-2-methylpentanedioyl-coenzyme A	Biochemical Assay Reagents	Others
(2S,3R)-3-Hydroxy-2-methylpentanedioyl-CoA ((2S,3R)-3-Hydroxy-2-methylpentanedioyl-coenzyme A) is a derivative of Coenzyme A (HY-128851).

HY-W010271

(2S,3R,4S)-4-Hydroxyisoleucine (2S,3r,4S)-4-Hydroxy-L-isoleucine	Insulin Receptor	Metabolic Disease
(2S,3R,4S)-4-Hydroxyisoleucine is an orally active compound. (2S,3R,4S)-4-Hydroxyisoleucine can be isolated from Trigonella foenum-graecum. (2S,3R,4S)-4-Hydroxyisoleucine has anti-diabetic and anti-diabetic nephropathy activity ^[1] ^[3].

HY-129883

(3R)-Hydroxyquinidine	Drug Metabolite	Cardiovascular Disease
(3R)-Hydroxyquinidine is the major metabolite of Quinidine (HY-B1751) ^[1].

HY-CE00206

(3R,11Z,14Z)-3-Hydroxyicosadienoyl-CoA (3r,11Z,14Z)-3-Hydroxyicosadienoyl-coenzyme A	Biochemical Assay Reagents	Others
(3R,11Z,14Z)-3-Hydroxyicosadienoyl-CoA ((3R,11Z,14Z)-3-Hydroxyicosadienoyl-coenzyme A) is a 3-hydroxy fatty acyl-CoA.

HY-60263

(3R)-3-Pyrrolidinemethanol	PROTAC Linkers	Others
(3R)-3-Pyrrolidinemethanol is a molecular building block and the linker of NRX-0492 (HY-153357).

HY-W012864S1

(2S,3R)-2,3,4-Trihydroxybutanal-13C-1	Isotope-Labeled Compounds	Others
(2S,3R)-2,3,4-Trihydroxybutanal- ¹³C-1 is the ¹³C labeled (2S,3R)-2,3,4-Trihydroxybutanal ^[1].

HY-W012864S2

(2S,3R)-2,3,4-Trihydroxybutanal-13C-2	Isotope-Labeled Compounds	Others
(2S,3R)-2,3,4-Trihydroxybutanal- ¹³C-2 is the ¹³C labeled (2S,3R)-2,3,4-Trihydroxybutanal ^[1].

HY-40354D

(3R,4S)-Tofacitinib	JAK	Inflammation/Immunology
(3R,4S)-Tofacitinib is an less active enantiomer of Tofacitinib. Tofacitinib inhibits *JAK3* with IC₅₀ of 1 nM.

HY-W063149

(1S,3R)-3-Aminocyclopentanol	Drug Intermediate	Others
(1S,3R)-3-Aminocyclopentanol is a synthetic intermediate useful for pharmaceutical synthesis.

HY-14664B

(3R,5S)-Fluvastatin (3r,5S)-XU 62-320 free acid	HMG-CoA Reductase (HMGCR) Autophagy	Cardiovascular Disease Cancer
(3R,5S)-Fluvastatin is the 3R,5S-isomer Fluvastatin. Fluvastatin (XU 62-320 free acid) is a first fully synthetic, competitive HMG-CoA reductase inhibitor with an IC₅₀ of 8 nM. Fluvastatin protects vascular smooth muscle cells against oxidative stress through the Nrf2-dependent antioxidant pathway ^[1] ^[3].

HY-116227

(2S,3R)-LP99	Epigenetic Reader Domain	Inflammation/Immunology
(2S,3R)-LP99 is a potent and selective BRD7 and BRD9 inhibitor with an K_D of 99 nM for BRD9. (2S,3R)-LP99 inhibits the association of BRD7 and BRD9 to acetylated histones in vitro and in cells. (2S,3R)-LP99 demonstrates that BRD7/9 plays a role in regulating pro-inflammatory cytokine secretion ^[1].

HY-N1976

(+)-(3R,8S)-Falcarindiol 1 Publications Verification (3r,8S)-Falcarindiol; 3(R),8(S),9(Z)-Falcarindiol	Bacterial	Infection Inflammation/Immunology Cancer
(+)-(3R,8S)-Falcarindiol is a polyacetylene found in carrots, has antimycobacterial activity, with an IC₅₀ of 6 μM and MIC of 24 μM against Mycobacterium tuberculosis H37Ra ^[1] . Antineoplastic and anti-inflammatory activity . (+)-(3R,8S)-Falcarindiol is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-N0894A

(3R,5R)-Octahydrocurcumin (3r,5R)-Hexahydrobisdemethoxycurcumin	Drug Metabolite	Neurological Disease Inflammation/Immunology
(3R,5R)-Octahydrocurcumin (Compound 7) is gut microbial metabolite of Curcumin (HY-N0005). (3R,5R)-Octahydrocurcumin exhibits neuroprotective efficacy against Aβ25-35-induced cell damage in SH-SY5Y, and anti-inflammatory activity against LPS-stimulated mouse microglial BV-2 ^[1].

HY-129214

(2S,3R)-DEPMPO-Biotin	Reactive Oxygen Species (ROS)	Inflammation/Immunology
(2S,3R)-DEPMPO-Biotin is a spin trapping agent consists of DEPMPO (HY-120976) and Biotin (HY-B0511). (2S,3R)-DEPMPO-Biotin captures macromolecule free radicals in lesions ^[1].

HY-121161B

(2S,3R)-Brassinazole	Drug Isomer	Metabolic Disease
(2S,3R)-Brassinazole, the enantiomer of Brassinazole (BRZ). Brassinazole inhibits brassinosteroid (BR) biosynthesis, via acting on the oxidative processes from 6-oxo-campestanol to teasterone. (2S,3R)-Brassinazole might be the most active form of Brz ^[1] ^[3].

HY-124534

(1S,3R)-3-Aminocyclopentane carboxylic acid	GABA Receptor	Neurological Disease
(1S,3R)-3-Aminocyclopentane carboxylic acid has GABAA receptor activity ^[1].

HY-122938

Ceplignan (2S,3r)-Ceplignan	Others	Others
Ceplignan ((2S,3R)-Ceplignan) is a neogenic lignan, which can be isolated from the rhizomes of Acorus tatarinowii Schott. (2S,3R)-Ceplignan and (2R,3S)-ceplignan are two isomers of Ceplignan ^[1].

HY-CE00207

(3R,11Z,14Z,17Z)-3-Hydroxyicosatrienoyl-CoA (3r,11Z,14Z,17Z)-3-Hydroxyicosatrienoyl-coenzyme A	Biochemical Assay Reagents	Others
(3R,11Z,14Z,17Z)-3-Hydroxyicosatrienoyl-CoA ((3R,11Z,14Z,17Z)-3-Hydroxyicosatrienoyl-coenzyme A) is an unsaturated fatty acyl-CoA.

HY-12422B

(2S,3R)-Voruciclib hydrochloride	CDK	Cancer
(2S,3R)-Voruciclib hydrochloride is the enantiomer of Voruciclib hydrochloride. Voruciclib is an orally active CDK inhibitor.

HY-137440B

(2R,3R)-Firazorexton (2R,3r)-TAK-994 free base	Orexin Receptor (OX Receptor)	Neurological Disease
(2R,3R)-Firazorexton ((2R,3R)-TAK-994 free base) is an isomer of Firazorexton (HY-137440). Firazorexton is an orally active, brain-penetrating orexin type 2 receptor (OX2R) agonist that may improve narcolepsy-like symptoms ^[1]..

HY-W061439

(3R,5S)-5-O-DMT-3-pyrrolidinol	Nucleoside Antimetabolite/Analog	Others
(3R,5S)-5-O-DMT-3-pyrrolidinol is a compound with a dimethoxytrityl (DMT) protecting group and a 3-pyrrolidinol structure. (3R,5S)-5-O-DMT-3-pyrrolidinol can be used in the synthesis of nucleic acids.

HY-N8186

(3R)-7,4’-Dihydrohomoisoflavanone	Bacterial	Infection
(3R)-7,4’-Dihydrohomoisoflavanone is a natural product with antibacterial activities against *S. aureus* and *methicillin-resistant Staphylococcus aureus* (MRSA)** ^[1].

HY-N12992

(3R)-3′,8-Dihydroxyvestitol	Others	Others
(3R)-3′,8-Dihydroxyvestitol (compound DO-9) is an isoflavonoid monomer that can be isolated from Dalbergia odorifera. I ^[1].

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W010271

(2S,3R,4S)-4-Hydroxyisoleucine (2S,3r,4S)-4-Hydroxy-L-isoleucine	Classification of Application Fields Leguminosae Ketones, Aldehydes, Acids Source classification Metabolic Disease Plants Trigonella foenum-graecum Linn. Disease Research Fields	Insulin Receptor
(2S,3R,4S)-4-Hydroxyisoleucine is an orally active compound. (2S,3R,4S)-4-Hydroxyisoleucine can be isolated from Trigonella foenum-graecum. (2S,3R,4S)-4-Hydroxyisoleucine has anti-diabetic and anti-diabetic nephropathy activity ^[1] ^[3].

HY-N1976

(+)-(3R,8S)-Falcarindiol 1 Publications Verification (3r,8S)-Falcarindiol; 3(R),8(S),9(Z)-Falcarindiol	Infection Natural Products Classification of Application Fields Source classification Decachaeta ovatifolia (DC.) R.M.King & H.Rob. Umbelliferae Plants Inflammation/Immunology Disease Research Fields	Bacterial
(+)-(3R,8S)-Falcarindiol is a polyacetylene found in carrots, has antimycobacterial activity, with an IC₅₀ of 6 μM and MIC of 24 μM against Mycobacterium tuberculosis H37Ra ^[1] . Antineoplastic and anti-inflammatory activity . (+)-(3R,8S)-Falcarindiol is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-N8917

(3R)-7-hydroxy-3-(4-hydroxybenzyl)chromane	Dracaena cochinchinensis (Lour.) S. C. Chen Source classification Phenols Polyphenols Agavaceae Plants	Phosphatase
(3R)-7-hydroxy-3-(4-hydroxybenzyl)chromane is a homoisoflavonoid. (3R)-7-hydroxy-3-(4-hydroxybenzyl)chromane increases the level of alkaline phosphatase (ALP) activity. (3R)-7-hydroxy-3-(4-hydroxybenzyl)chromane promotes mesenchymal stem cells (MSCs) osteogenesis, but cannot enhance MSCs proliferation. (3R)-7-hydroxy-3-(4-hydroxybenzyl)chromane can be used for osteoporosis research ^[1].

HY-133872

[(3R)-3-Hydroxydodecanoyl]-L-carnitine	Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
[(3R)-3-Hydroxydodecanoyl]-L-carnitine is an endogenous metabolite ^[1].

HY-N0894A

(3R,5R)-Octahydrocurcumin (3r,5R)-Hexahydrobisdemethoxycurcumin	Source classification Phenols Polyphenols Plants Tacca chantrieri Andre Taccaceae	Drug Metabolite
(3R,5R)-Octahydrocurcumin (Compound 7) is gut microbial metabolite of Curcumin (HY-N0005). (3R,5R)-Octahydrocurcumin exhibits neuroprotective efficacy against Aβ25-35-induced cell damage in SH-SY5Y, and anti-inflammatory activity against LPS-stimulated mouse microglial BV-2 ^[1].

HY-122938

Ceplignan (2S,3r)-Ceplignan	Araceae Source classification Acorus gramineus Soland. Phenols Plants	Others
Ceplignan ((2S,3R)-Ceplignan) is a neogenic lignan, which can be isolated from the rhizomes of Acorus tatarinowii Schott. (2S,3R)-Ceplignan and (2R,3S)-ceplignan are two isomers of Ceplignan ^[1].

HY-N8186

(3R)-7,4’-Dihydrohomoisoflavanone	Infection Flavonoids Dracaena cambodiana Pierre ex Gagnep. Classification of Application Fields Flavonones Source classification Phenols Polyphenols Agavaceae Plants Disease Research Fields	Bacterial
(3R)-7,4’-Dihydrohomoisoflavanone is a natural product with antibacterial activities against *S. aureus* and *methicillin-resistant Staphylococcus aureus* (MRSA)** ^[1].

HY-N12992

(3R)-3′,8-Dihydroxyvestitol	Dalbergia odorifera T. Chen Leguminosae Source classification Phenols Polyphenols Plants	Others
(3R)-3′,8-Dihydroxyvestitol (compound DO-9) is an isoflavonoid monomer that can be isolated from Dalbergia odorifera. I ^[1].

HY-N13500

(2R,3R)-Glucodistylin	Flavonoids Source classification Rhododendron mucronulatum Turcz. Ericaceae Plants Other Flavonoids	Others
(2R,3R)-Glucodistylin is a flavonoid product that can be isolated from Rhododendron mucronulatum ^[1].

HY-N10862

(3R)-6,4'-Dihydroxy-8-methoxyhomoisoflavan	Flavonoids Dracaena draco (L.) L. Source classification Agavaceae Plants Other Flavonoids	Others
(3R)-6,4'-Dihydroxy-8-methoxyhomoisoflavan is a natural product that can be isolated from the red resin of Dracaena cochinchinensis ^[1].

HY-N0962

(3R)-Hydrangenol 8-O-glucoside pentaacetate	Flavonoids Hydrangeaceae Source classification Plants Other Flavonoids	Others
(3R)-Hydrangenol 8-O-glucoside pentaacetate is a Flavonoids product that can be isolated from the herbs of Hydrangea macrophylla ^[1].

HY-W015954R

(2R,3R)-Butane-2,3-diol (Standard)	Natural Products Human Gut Microbiota Metabolites Microorganisms Source classification Endogenous metabolite	Reference Standards Endogenous Metabolite Calcium Channel Bacterial
(2R,3R)-Butane-2,3-diol (Standard) is the analytical standard of (2R,3R)-Butane-2,3-diol (HY-W015954). This product is intended for research and analytical applications. (2R,3R)-Butane-2,3-diol is a non-covalent, reversible agonist targeting *lanthanum (La ³⁺)-sensitive* calcium channels in bacteria (e.g., Escherichia coli) with an EC₅₀** of approximately 25 mM. (2R,3R)-Butane-2,3-diol binds to calcium channel proteins or related complexes, induces channel opening, promotes extracellular calcium influx, and triggers intracellular calcium transients, which may regulate bacterial physiological activities such as growth, metabolism, and signal transduction. (2R,3R)-Butane-2,3-diol mediates bacterial-host cell signaling interactions and affects the metabolic balance of intestinal microorganisms, and can be used to study lactose intolerance and other related diseases ^[1].

HY-N13414

(3R,5S,E)-1,7-Diphenylhept-1-ene-3,5-diol	Source classification Phenols Polyphenols Plants Curcuma longa Zingiberaceae	Others
(3R,5S,E)-1,7-Diphenylhept-1-ene-3,5-diol is a natural product ^[1].

HY-108059

β-Cryptoxanthin (3r)-β-Cryptoxanthin	Other Terpenoids Capsicum annuum L. other families Neurological Disease Classification of Application Fields Terpenoids Source classification Plants Solanaceae Endogenous metabolite Disease Research Fields	Endogenous Metabolite
β-Cryptoxanthin ((3R)-β-Cryptoxanthin), isolated from tangerines, red peppers, and pumpkin, is an oxygenated carotenoid and a potent antioxidant. β-Cryptoxanthin has an anti-stress effect ^[1].

HY-W015954

(2R,3R)-Butane-2,3-diol	Natural Products Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite Calcium Channel Bacterial
(2R,3R)-Butane-2,3-diol is a non-covalent, reversible agonist targeting lanthanum (La ³⁺)-sensitive calcium channels in bacteria (e.g., Escherichia coli) with an EC₅₀ of approximately 25 mM. (2R,3R)-Butane-2,3-diol binds to calcium channel proteins or related complexes, induces channel opening, promotes extracellular calcium influx, and triggers intracellular calcium transients, which may regulate bacterial physiological activities such as growth, metabolism, and signal transduction. (2R,3R)-Butane-2,3-diol mediates bacterial-host cell signaling interactions and affects the metabolic balance of intestinal microorganisms, and can be used to study lactose intolerance and other related diseases ^[1].

HY-N16375

(3R,6S)-Bassiatin	Natural Products Microorganisms Source classification	Drug Metabolite Fungal ATP Synthase
(3R,6S)-Bassiatin (Compound 5) is an enantiomer of the fungal metabolite Bassiatin (HY-165143). Bassianin is a compound isolated from fungi that has the activity of inhibiting erythrocyte membrane ATPase and causing cell lysis. Its inhibitory effect on ATPase may be due to membrane disruption ^[1] .

HY-N15206

(3R,5R)-1-(4-Hydroxy-3-methoxyphenyl)-7-phenylheptane-3,5-diol	Monophenols Source classification Phenols Alpinia officinarum Hance Plants Zingiberaceae	Endogenous Metabolite
(3R,5R)-1-(4-Hydroxy-3-methoxyphenyl)-7-phenylheptane-3,5-diol (compound 20) is a plant metabolite that can be isolated from Zingiberaceae plants ^[1].

HY-N16409

Berkeleyamide C	Natural Products Microorganisms Source classification	MMP Caspase
Berkeleyamide C is a selective matrix metalloproteinase-3 (MMP-3) and *caspase-1* inhibitor. Berkeleyamide C blocks MMP-3-mediated tumor cell invasion and metastasis, as well as the abnormal activation of inflammation and apoptosis related to caspase-1. Berkeleyamide C is promising for research of cancers and inflammation-related diseases ^[1].

HY-N2296

(2R,3R)-3,7-Dihydroxy-2-(4-hydroxyphenyl)-5-methoxy-8-(3-methylbut-2-en-1-yl)chroman-4-one	Flavanonols Flavonoids Classification of Application Fields Leguminosae Source classification Other Diseases Phenols Polyphenols Sophora flavescens Aiton Plants Disease Research Fields	Others
(2R,3R)-3,7,4'-Trihydroxy-5-methoxy-8-prenylflavanone can be used in a flame retardant for transparent polycarbonate products or in elevator illumination devices research ^[1] .

HY-N8733

p-Menth-1-ene-3,6-diol (3r,4R,6S)-3,6-Dihydroxy-1-menthene	Natural Products Labiatae Source classification Erythrina poeppigiana Plants	Others
p-Menth-1-ene-3,6-diol ((3R,4R,6S)-3,6-Dihydroxy-1-menthene) is a Flavonoids product that can be isolated from the roots of Pueraria lobata ^[1].

HY-N15207

(3R,5R)-1-(4-Hydroxyphenyl)-7-phenyl-3,5-heptanediol	Monophenols Source classification Phenols Alpinia officinarum Hance Plants Zingiberaceae	Others
(3R,5R)-1-(4-Hydroxyphenyl)-7-phenyl-3,5-heptanediol is an antiemetic found in Alpinia officinarum that significantly inhibits copper sulfate-induced emesis in young chicks (with an inhibition rate of 50.9% at a dose of 20 mg/kg and 37.7% at a dose of 50 mg/kg) ^[1].

HY-W021425

D-Mannosamine hydrochloride 1 Publications Verification (2S,3r,4S,5R)-2-Amino-3,4,5,6-tetrahydroxyhexanal hydrochloride	Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Saccharides	Drug Derivative
D-Mannosamine ((2S,3R,4S,5R)-2-Amino-3,4,5,6-tetrahydroxyhexanal) hydrochloride is a six-carbon amino sugar and an amino derivative of D-mannose. D-Mannosamine hydrochloride can block mannose receptors ^[1].

HY-N9093

(3R,5R)-3,5-Diacetoxy-1-(3,4-dihydroxyphenyl)-7-(4-hydroxyphenyl)heptane	Source classification Phenols Curcuma kwangsiensis S. K. Lee & C. F. Liang Plants Zingiberaceae	Others
(3R,5R)-3,5-Diacetoxy-1-(3,4-dihydroxyphenyl)-7-(4-hydroxyphenyl)heptane, a diarylheptanoid from the rhizomes of Curcuma kwangsiensis, possesses a variety of biological and pharmacological activities including antioxidant, antihepa totoxic, anti-inflammatory, antiproliferative, antiemetic, and antitumor activities ^[1].

HY-N16408

Berkeleyamide B	Natural Products Microorganisms Source classification	MMP Caspase
Berkeleyamide B is a dual matrix metalloproteinase-3 (MMP-3) and *caspase-1* inhibitor. Berkeleyamide B is promising for research of cancers and inflammatory disease (e.g., rheumatoid arthritis) ^[1].

HY-N11163

(Z)-(1R,3R,4R,4aS,8R,8aR)-3,4,8,8a-Tetramethyl-7-oxo-4-(2-(5-oxo-2,5-dihydrofuran-3-yl)ethyl)decahydronaphthalen-1-yl 2-methylbut-2-enoate	Terpenoids Source classification Diterpenoids Plants Compositae Glycyrrhiza lepidota Pursh	Others
(Z)-(1R,3R,4R,4aS,8R,8aR)-3,4,8,8a-Tetramethyl-7-oxo-4-(2-(5-oxo-2,5-dihydrofuran-3-yl)ethyl)decahydronaphthalen-1-yl 2-methylbut-2-enoate (compound 7a) is a clerodane diterpene ^[1].

HY-101092

QS-21-Api 5 Publications Verification Stimulon	Triterpenes other families Classification of Application Fields Terpenoids Source classification Plants Inflammation/Immunology Disease Research Fields	NOD-like Receptor (NLR)
QS-21-Api, an immunostimulatory saponin, could be used as a potent vaccine adjuvant. QS-21-Api stimulates Th2 humoral and *Th1* cell-mediated immune responses through action on antigen presenting cells (APCs) and T cells. QS-21-Api can activate the *NLRP3* inflammasome with subsequent release of caspase-1 dependent cytokines, IL-1β and IL-18 ^[1] ^[3].

HY-W041489

Chelidonic acid 1 Publications Verification	Classification of Application Fields Chelidonium majus Ketones, Aldehydes, Acids Source classification Plants Disease Research Fields Papaveraceae Cancer	NF-κB Caspase
Chelidonic acid is a component of Chelidonium majus L., used as an antimicrobial. Chelidonic acid also shows anti-inflammatory activity. Chelidonic acid has potential to inhibit IL-6 production by blocking NF-κB and *caspase-1* ^[1]. Chelidonic acid is a glutamate decarboxylase inhibitor, with a K_i of 1.2 μM .

HY-W041489R

Chelidonic acid (Standard)	Chelidonium majus Ketones, Aldehydes, Acids Source classification Plants Papaveraceae	Reference Standards NF-κB Caspase
Chelidonic acid (Standard) is the analytical standard of Chelidonic acid. This product is intended for research and analytical applications. Chelidonic acid is a component of Chelidonium majus L., used as an antimicrobial. Chelidonic acid also shows anti-inflammatory activity. Chelidonic acid has potential to inhibit IL-6 production by blocking NF-κB and caspase-1 ^[1]. Chelidonic acid is a glutamate decarboxylase inhibitor, with a Ki of 1.2 μM .

HY-N0619

Mulberroside A 4 Publications Verification	Stilbenes Classification of Application Fields Source classification Phenols Polyphenols Morus alba L. Plants Moraceae Inflammation/Immunology Disease Research Fields	TNF Receptor Interleukin Related Tyrosinase
Mulberroside A is one of the main bioactive constituent in mulberry (Morus alba L.) ^[1]. Mulberroside A decreases the expressions of TNF-α, *IL-1β, and IL-6* and inhibits the activation of NALP3, caspase-1, and NF-κB and the phosphorylation of ERK, JNK, and p38, exhibiting anti-inflammatory antiapoptotic effects . Mulberroside A shows inhibitory activity against mushroom tyrosinase with an IC₅₀ of 53.6 μM ^[3].

HY-N0619A

cis-Mulberroside A Mulberroside D	Stilbenes Classification of Application Fields Source classification Phenols Polyphenols Plants Moraceae Inflammation/Immunology Disease Research Fields Morus alba Linn.	TNF Receptor Interleukin Related Tyrosinase
cis-Mulberroside A (Mulberroside D) is the cis-isomer of Mulberroside A. Mulberroside A is one of the main bioactive constituent in mulberry (Morus alba L.) ^[1]. Mulberroside A decreases the expressions of TNF-α, *IL-1β, and IL-6* and inhibits the activation of NALP3, caspase-1, and NF-κB and the phosphorylation of ERK, JNK, and p38, exhibiting anti-inflammatory and anti-apoptotic effects . Mulberroside A shows inhibitory activity against mushroom tyrosinase with an IC₅₀ of 53.6 μM ^[3].

HY-N0619R

Mulberroside A (Standard)	Stilbenes Source classification Phenols Polyphenols Morus alba L. Plants Moraceae	Reference Standards TNF Receptor Interleukin Related Tyrosinase
Mulberroside A (Standard) is the analytical standard of Mulberroside A. This product is intended for research and analytical applications. Mulberroside A is one of the main bioactive constituent in mulberry (Morus alba L.) ^[1]. Mulberroside A decreases the expressions of TNF-α, IL-1β, and IL-6 and inhibits the activation of NALP3, caspase-1, and NF-κB and the phosphorylation of ERK, JNK, and p38, exhibiting anti-inflammatory antiapoptotic effects . Mulberroside A shows inhibitory activity against mushroom tyrosinase with an IC₅₀ of 53.6 μM ^[3].

HY-W011978

N-Acetyl-L-tryptophan	Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite Mitochondrial Metabolism Neurokinin Receptor Caspase Interleukin Related
N-Acetyl-L-tryptophan is an antagonist of the neurokinin-1 receptor (NK-1R), disrupting the binding of substance P (SP) to *NK-1R. This action provides neuroprotective effects, improving memory deficits and motor impairments. N-Acetyl-L-tryptophan is also an inhibitor of cytochrome c (Cytochrome c), and it exerts antioxidant and anti-inflammatory effects by inhibiting the expression of IL-1β* and the activation of *caspase-1*. N-Acetyl-L-tryptophan holds promise for research in neurodegenerative and inflammatory diseases ^[1] ^[3] .

HY-N15690

3-(R)-3-β-Glucopyranosyloxy-4-hydroxybutanoic acid	Orchidaceae Anoectochilus formosanus Hayata Source classification Plants Saccharides Monosaccharides	Biochemical Assay Reagents
3-(R)-3-β-Glucopyranosyloxy-4-hydroxybutanoic acid is a butanoic acid glucose. 3-(R)-3-β-Glucopyranosyloxy-4-hydroxybutanoic acid can be isolated from the methanol extract of dried whole plants of Anoectochilus formosanus Hay. 3-(R)-3-β-Glucopyranosyloxy-4-hydroxybutanoic acid can be formed in 3 types of regenerated plantlets in vitro ^[1].

HY-N1431

Tabersonine 3 Publications Verification	Apocynaceae Alkaloids Source classification Plants Indole Alkaloids Catharanthus roseus (L.) G. Don	NOD-like Receptor (NLR) Apoptosis Cytochrome P450 NF-κB PI3K Akt CDK Caspase Interleukin Related p38 MAPK
Tabersonine is a selective, orally active *NLRP3* inhibitor. Tabersonine directly binds to the NACHT domain of NLRP3, inhibiting its ATPase activity and oligomerization, thereby blocking ASC spot formation and *caspase-1* activation, and reducing the release of pro-inflammatory cytokines such as *IL-1β. Tabersonine also inhibits K63-linked ubiquitination of TRAF6, blocking NF-κB, PI3K/Akt, and p38 MAPK* signaling pathways. Tabersonine can inhibit inflammatory responses, induce apoptosis of liver cancer cells through mitochondrial pathways and death receptor pathways, reduce mitochondrial membrane potential, promote cytochrome c release, and activate caspase proteins. Tabersonine is mainly used in the study of NLRP3-driven inflammatory diseases (such as acute lung injury, sepsis, peritonitis) and tumors such as liver cancer ^[1] ^[3].

HY-N1431A

Tabersonine hydrochloride	Apocynaceae Alkaloids Source classification Plants Indole Alkaloids Catharanthus roseus (L.) G. Don	NOD-like Receptor (NLR) Apoptosis Cytochrome P450 NF-κB PI3K Akt CDK Caspase Interleukin Related p38 MAPK
Tabersonine hydrochloride is a selective, orally active *NLRP3* inhibitor. Tabersonine hydrochloride directly binds to the NACHT domain of NLRP3, inhibiting its ATPase activity and oligomerization, thereby blocking ASC spot formation and *caspase-1* activation, and reducing the release of pro-inflammatory cytokines such as *IL-1β. Tabersonine hydrochloride also inhibits K63-linked ubiquitination of TRAF6, blocking NF-κB, PI3K/Akt, and p38 MAPK* signaling pathways. Tabersonine hydrochloride can inhibit inflammatory responses, induce apoptosis of liver cancer cells through mitochondrial pathways and death receptor pathways, reduce mitochondrial membrane potential, promote cytochrome c release, and activate caspase proteins. Tabersonine hydrochloride is mainly used in the study of NLRP3-driven inflammatory diseases (such as acute lung injury, sepsis, peritonitis) and tumors such as liver cancer ^[1] ^[3].

HY-B2176R

ATP (Standard) Adenosine 5'-triphosphate (Standard)	Alkaloids Human Gut Microbiota Metabolites Microorganisms other families Animals Other Alkaloids Source classification Plants Endogenous metabolite	Reference Standards Endogenous Metabolite
ATP (Standard) is the analytical standard of ATP. This product is intended for research and analytical applications. ATP (Adenosine 5'-triphosphate) is a central component of energy storage and metabolism in vivo. ATP provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP is an important endogenous signaling molecule in immunity and inflammation ^[1] . In Vitro: ATP (5 mM; 1 hour) co-treatment with LPS (1 μg/mL) has a synergistic effect on the activation of the NLRP3 inflammasome in HGFs ^[3]. ATP (2 mM; 0.5-24 hours) induces secretion of IL-1β, KC and MIP-2 from BMDMs in a caspase-1 activation-dependent manner . ATP promotes neutrophil chemotaxis in vitro . In Vivo: ATP (50 mg/kg; i.p.) protects mice against bacterial infection in vivo . ATP induces the secretion of IL-1β, KC and MIP-2 and neutrophils recruitment in vivo .

HY-130413

Protectin D1 Neuroprotectin D1; NPD1	Neurological Disease Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Disease Research Fields	Endogenous Metabolite PI3K Akt HIF/HIF Prolyl-Hydroxylase Reactive Oxygen Species (ROS) Caspase Interleukin Related MicroRNA
Protectin D1, a neuroprotectin D1 produced by neuronal cells, is a member of a newly discovered family of bioactive products derived from docosahexaenoic acid. Protectin D1 also serves as a specialized pro-resolving mediator, exhibiting effective in vivo pro-resolving activity in various human disease models. Additionally, Protectin D1 is an inhibitor of *NALP3* inflammasomes and regulates the *PI3K/AKT* and *HIF-1α* signaling pathways. Protectin D1 exerts anti-inflammatory effects by reducing ROS levels, inhibiting the expression of *NALP3, ASC, and Caspase-1, and consequently decreasing the release of pro-inflammatory cytokines IL-1β* and IL-18. Furthermore, Protectin D1 enhances miRNA-210 expression, activates the *PI3K/AKT* signaling pathway, and exerts cardioprotective effects. Protectin D1 holds promise for research in cardiovascular diseases and inflammatory disorders ^[1] .

HY-W750654

Adonixanthin (3S,3′R)-Adonixanthin	Natural Products Microorganisms Source classification	Akt ERK p38 MAPK MMP NADPH Oxidase Reactive Oxygen Species (ROS) Keap1-Nrf2
Adonixanthin ( (3S,3'R)-Adonixanthin), a carotenoid, is an orally active anti-oxidative and anti-carcinogenic agent. Adonixanthin shows an ability to suppress cell proliferation and migration in three types of glioblastoma cells Adonixanthin exerts cytoprotective effects against various types of damage and inhibits the increased production of ROS. Adonixanthin protects against light-induced cell damage through not only an anti-oxidative response but also through Nrf2 activation. Adonixanthin suppresses glioblastoma progression and adonixanthin improves blood-brain barrier hyper-permeability in an autologous blood ICH model. Adonixanthin can be used for the study of glioblastoma (GBM) and intracerebral hemorrhage (ICH) ^[1].

HY-W015851R

(R)-3-Hydroxybutanoic acid sodium (Standard) (R)-(-)-3-Hydroxybutanoic acid sodium (Standard); (R)-3-Hydroxybutyric acid sodium (Standard)	Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Reference Standards Endogenous Metabolite
(R)-3-Hydroxybutanoic acid (sodium) (Standard) is the analytical standard of (R)-3-Hydroxybutanoic acid (sodium). This product is intended for research and analytical applications. (R)-3-Hydroxybutanoic acid ((R)-3-Hydroxybutyric acid) sodium is a metabolite converted from acetoacetic acid catalyzed by 3-hydroxybutyrate dehydrogenase. (R)-3-Hydroxybutanoic acid sodium can function as a nutrition source, and as a precursor for vitamins, antibiotics and pheromones[1][2].

HY-W051723R

(R)-3-Hydroxybutanoic acid (Standard) (R)-(-)-3-Hydroxybutanoic acid (Standard); (R)-3-Hydroxybutyric acid (Standard)	Immune System Disorder Ketones, Aldehydes, Acids Source classification Disease markers Endocrine diseases Nervous System Disorder Endogenous metabolite Cardiovascular System Disorder	Reference Standards Endogenous Metabolite
(R)-3-Hydroxybutanoic acid (Standard) is the analytical standard of (R)-3-Hydroxybutanoic acid. This product is intended for research and analytical applications. (R)-3-Hydroxybutanoic acid is a metabolite, and converted from acetoacetic acid catalyzed by 3-hydroxybutyrate dehydrogenase. (R)-3-Hydroxybutanoic acid has applications as a nutrition source and as a precursor for vitamins, antibiotics and pheromones[1][2].

HY-W015851

(R)-3-Hydroxybutanoic acid sodium 5 Publications Verification (R)-(-)-3-Hydroxybutanoic acid sodium; (R)-3-Hydroxybutyric acid sodium	Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Endogenous Metabolite
(R)-3-Hydroxybutanoic acid ((R)-3-Hydroxybutyric acid) sodium is a metabolite converted from acetoacetic acid catalyzed by 3-hydroxybutyrate dehydrogenase. (R)-3-Hydroxybutanoic acid sodium can function as a nutrition source, and as a precursor for vitamins, antibiotics and pheromones ^[1] .

HY-130476

Satratoxin G	Microorganisms Terpenoids Sesquiterpenes Source classification	Caspase Apoptosis
Satratoxin G is a large cyclic mucor toxin. Satratoxin G induces apoptosis by activation of *caspase* .

HY-N1093

(-)-Vestitol (3r)-Vestitol	Glycyrrhiza pallidiflora Maxim. Classification of Application Fields Leguminosae Source classification Other Diseases Phenols Plants Disease Research Fields	Others
(-)-Vestitol is a compound isolated from Glycyrrhiza pallidiflora (Leguminosae) ^[1].

HY-N12235

Sarglaroids F	Ketones, Aldehydes, Acids Source classification Sarcandra glabra (Thunb.) Nakai Chloranthaceae Plants	Caspase
Sarglaroids F (compound 6) is an anti-inflammatory agent isolated from the roots of Grass Coral. Sarglaroids F inhibits LPS/ATP-induced IL-1β release by affecting K+ efflux and reducing Caspase-1(P20) levels. Sarglaroids F is not cytotoxic to RAW264.7 cells ^[1].

HY-N0816

Polyphyllin VI 5+ Cited Publications	other families Classification of Application Fields Source classification Plants Disease Research Fields Steroids Cancer	Apoptosis Pyroptosis
Polyphyllin VI, an active saponin, possess anti-cancer activities. Polyphyllin VI induces G2/M cell cycle arrest and triggers apoptosis. Polyphyllin VI induces *caspase-1*-mediated pyroptosis via the induction of ROS/NF-κB/NLRP3/GSDMD signal axis in non-small cell lung cancer ^[1] ^[3].

HY-W051723

(R)-3-Hydroxybutanoic acid 5 Publications Verification (R)-(-)-3-Hydroxybutanoic acid; (R)-3-Hydroxybutyric acid	Immune System Disorder Classification of Application Fields Anti-aging Ketones, Aldehydes, Acids Source classification Disease markers Other Diseases Endocrine diseases Nervous System Disorder Endogenous metabolite Disease Research Fields Cardiovascular System Disorder	Endogenous Metabolite
(R)-3-Hydroxybutanoic acid is a metabolite, and converted from acetoacetic acid catalyzed by 3-hydroxybutyrate dehydrogenase. (R)-3-Hydroxybutanoic acid has applications as a nutrition source and as a precursor for vitamins, antibiotics and pheromones ^[1] .

HY-I1060

L-Alloisoleucine 1 Publications Verification (3r)-LS-Isoleucine	Immune System Disorder Classification of Application Fields Source classification Disease markers Other Diseases Amino acids Endogenous metabolite Disease Research Fields	Endogenous Metabolite
L-Alloisoleucine is a stereoisomer of L-isoleucine. L-Alloisoleucine can be used in skeletal muscle research ^[1].

HY-N0816R

Polyphyllin VI (Standard)	other families Source classification Plants Steroids	Reference Standards Apoptosis Pyroptosis
Polyphyllin VI (Standard) is the analytical standard of Polyphyllin VI. This product is intended for research and analytical applications. Polyphyllin VI, an active saponin, possess anti-cancer activities. Polyphyllin VI induces G2/M cell cycle arrest and triggers apoptosis. Polyphyllin VI induces caspase-1-mediated pyroptosis via the induction of ROS/NF-κB/NLRP3/GSDMD signal axis in non-small cell lung cancer ^[1] ^[3].

HY-N15588

Smyrindiol (2'S, 3'R)-3'-Hydroxymarmesin	Natural Products Kitagawia formosana (Hayata) Pimenov Source classification Umbelliferae Plants	MMP
Smyrindiol is a compound found in Dorstenia turbinate. Smyrindiol exerts anti-inflammatory and antimicrobial activities by inhibiting the secretion of tumor-associated proteases (MMP-2). Smyrindiol can be used in the study of brain tumors such as glioblastoma ^[1].

HY-N2414

Periplogenin 1 Publications Verification	other families Classification of Application Fields Source classification Plants Inflammation/Immunology Disease Research Fields Steroids	Reactive Oxygen Species (ROS) Necroptosis Pyroptosis Interleukin Related
Periplogenin is a cardiac glycoside found in Cortex periplocae. Periplogenin can induce ROS production and necroptosis and cause G0/G1 phase arrest. Periplogenin can inhibit pyroptosis by regulating the NLRP3/Caspase-1/GSDMD signaling. Periplogenin suppresses growth of prostate carcinoma cells by docking to an ATP1A1 protein pocket and forming a hydrogen bond with T804. Periplogenin can be used for the researches of cancer, inflammation and immunology, such as prostate carcinoma, rheumatoid arthritis and psoriasis ^[1] ^[3].

Cat. No.	Product Name	Chemical Structure

HY-W012864S2

(2S,3R)-2,3,4-Trihydroxybutanal-13C-2
(2S,3R)-2,3,4-Trihydroxybutanal- ¹³C-2 is the ¹³C labeled (2S,3R)-2,3,4-Trihydroxybutanal ^[1].

HY-Z5058S

(3R,5S)-Fluvastatin-d7 sodium
(3R,5S)-Fluvastatin-d₇ (sodium) is the deuterium labeled (3R,5S)-Fluvastatin sodium ^[1].

HY-W699829

(3R,5R)-Rosuvastatin Lactone-d6
(3R,5R)-Rosuvastatin Lactone-d₆ is the deuterium labeled (3R,5R)-Rosuvastatin Lactone (HY-135406). (3R,5R)-Rosuvastatin Lactone is an isomer of Rosuvastatin Lactone.

HY-150092S

(2S,3R)-8(9)-EET-d11
(2S,3R)-8(9)-EET-d₁₁ is deuterium-labeled (2S,3R)-8(9)-EET (HY-150092) ^[1].

HY-W012864S

(2S,3R)-2,3,4-Trihydroxybutanal-13C
(2S,3R)-2,3,4-Trihydroxybutanal- ¹³C is the ¹³C labeled (2S,3R)-2,3,4-Trihydroxybutanal ^[1].

HY-W012864S1

(2S,3R)-2,3,4-Trihydroxybutanal-13C-1
(2S,3R)-2,3,4-Trihydroxybutanal- ¹³C-1 is the ¹³C labeled (2S,3R)-2,3,4-Trihydroxybutanal ^[1].

HY-Z1430S

(3R,4S)-Paroxetine-d4 hydrochloride
Paroxetine EP impurity D-d₄ (hydrochloride) is deuterium labeled (3R,4S)-3-((benzo[d][1,3]dioxol-5-yloxy)methyl)-4-(4-fluorophenyl)piperidine (Paroxetine Impurity).

HY-W654002

(3R)-3-Hydroxybutyric acid-1-13C
(3R)-3-Hydroxybutyric acid-1- ¹³C is ¹³C labeled (R)-3-Hydroxybutanoic acid. (R)-3-Hydroxybutanoic acid is a metabolite, and converted from acetoacetic acid catalyzed by 3-hydroxybutyrate dehydrogenase. (R)-3-Hydroxybutanoic acid has applications as a nutrition source and as a precursor for vitamins, antibiotics and pheromones ^[1] ^[3].

HY-W021425S1

D-Mannosamine-d2 hydrochloride
D-Mannosamine-d₂ (2S,3R,4S,5R)-2-Amino-3,4,5,6-tetrahydroxyhexanal-d₂) hydrochloride is a deuterium labeled D-Mannosamine hydrochloride (HY-W021425). D-Mannosamine ((2S,3R,4S,5R)-2-Amino-3,4,5,6-tetrahydroxyhexanal) hydrochloride is a six-carbon amino sugar and an amino derivative of D-mannose. D-Mannosamine hydrochloride can block mannose receptors.

HY-W242887S2

D-Gulose-13C
D-Gulose- ¹³C is the ¹³C labeled (2R,3R,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal ^[1].

HY-W242887S3

D-Gulose-1-13C
D-Gulose-1- ¹³C is the ¹³C labeled (2R,3R,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal ^[1].

HY-W741847

Tapentadol N-Oxide-d5
Tapentadol N-Oxide-d₅ is the deuterium labeled (2R,3R)-3-(3-Hydroxyphenyl)-N,N,2-trimethylpentan-1-amine oxide (HY-W703015).

HY-W722122

N-(1-(Adamantan-1-yl)ethyl)hydroxylamine-d4
N-(1-(Adamantan-1-yl)ethyl)hydroxylamine-d₄ (N-(1-((3r,5r,7r)-Adamantan-1-yl)ethyl)hydroxylamine-d₄) is the deuterium labeled N-(1-(adamantan-1-yl)ethyl)hydroxylamine (HY-75864).

HY-W725464

4-Methylsyringol Gentiobioside-d6
4-Methylsyringol Gentiobioside-d₆ is the deuterium labeled (2S,3R,4S,5S,6R)-2-(2,6-Dimethoxy-4-methylphenoxy)-6-((((2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)methyl)tetrahydro-2H-pyran-3,4,5-triol (HY-W725468).

HY-W759099

3-O-a-d-glucosyl isomaltol-d3
3-O-a-d-glucosyl isomaltol-d₃ is the deuterium labeled 1-(3-(((2R,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)furan-2-yl)ethan-1-one (HY-W715028).

HY-W768491

3',5'-Di-O-benzyl Entecavir-13C2,15N
3',5'-Di-O-benzyl Entecavir- ¹³C₂, ¹⁵N (The intermediate of Entecavir hydrate- ¹³C₂, ¹⁵N) is the ¹³C- and ¹⁵N-labeled 2-Amino-9-((1S,3R,4S)-4-(benzyloxy)-3-((benzyloxy)methyl)-2-methylenecyclopentyl)-1H-purin-6(9H)-one (HY-W105415).

HY-W714797

Nintedanib demethyl-O-glucuronic acid-d3
Nintedanib demethyl-O-glucuronic acid-d₃ is the deuterium labeled (2R,3R,4R,5S,6S)-3,4,5-Trihydroxy-6-(((Z)-3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carbonyl)oxy)tetrahydro-2H-pyran-2-carboxylic acid (HY-W712456).

HY-W753480

Phenol rutinoside-d5
Phenol rutinoside-d₅ is the deuterium labeled (2S,3R,4R,5R,6R)-2-Methyl-6-(((2R,3S,4S,5R,6S)-3,4,5-trihydroxy-6-phenoxytetrahydro-2H-pyran-2-yl)methoxy)tetrahydro-2H-pyran-3,4,5-triol (HY-W725466).

HY-W769530

Diosmetin 3',7-diglucuronide-d3
Diosmetin 3',7-diglucuronide-d₃ is the deuterium labeled (2S,3S,4S,5R,6S)-6-((2-(3-(((2S,3R,4S,5S,6S)-6-carboxy-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)oxy)-4-methoxyphenyl)-5-hydroxy-4-oxo-4H-chromen-7-yl)oxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid (HY-W401408).

HY-B1138S

Fenbufen-d9

Fenbufen-d₉ (CL-82204-d₉) is the deuterium labeled Fenbufen. Fenbufen (CL-82204) is an orally active non-steroidal anti-inflammatory drug (NSAID), with antipyretic effects. Fenbufen has potent activity in a variety of animal model, including carageenin edema, UV erythema and adjuvant arthritis. Fenbufen has inhibitory activities against COX-1 and COX-2 with IC₅₀s of 3.9 μM and 8.1 μM, respectively. Fenbufen is a caspases (caspase-1, 3, 4, 5, 9) inhibitor ^[1] ^[3] .

HY-100573S

Necrosulfonamide-d4

Necrosulfonamide-d₄ is the deuterium labeled Necrosulfonamide (HY-100573). Necrosulfonamide is a MLKL and Gasdermin D (GSDMD) inhibitor, capable of separately inhibiting necroptosis and pyroptosis of cells. Necrosulfonamide does not affect the activation of upstream signals, but specifically inhibits the downstream executor oligomerization step. Necrosulfonamide reduces the expression of the key kinases NLRP3 and caspase-1 involved in necroptosis and pyroptosis, activate the Nrf2 pathway and the downstream antioxidant enzymes, and also downregulates a variety of inflammatory factors. Necrosulfonamide plays significant roles in various diseases such as neurodegenerative diseases (such as Parkinson’s disease), tissue damage and ischemia-reperfusion injury, inflammatory bowel disease, osteoarthritis and fracture repair, and hair loss by regulating two important programmed necrosis pathways.

HY-W015851S2

(R)-3-Hydroxybutanoic acid-13C4 sodium
(R)-3-Hydroxybutanoic acid- ¹³C₄ sodium is a ¹³C labeled (R)-3-Hydroxybutanoic acid (HY-W051723). (R)-3-Hydroxybutanoic acid is a metabolite converted from acetoacetic acid catalyzed by 3-hydroxybutyrate dehydrogenase. (R)-3-Hydroxybutanoic acid can function as a nutrition source, and as a precursor for vitamins, antibiotics and pheromones ^[1] .

HY-B0228S10

(R)-3-Hydroxybutanoic acid-13C2 sodium
(R)-3-Hydroxybutanoic acid- ¹³C₂ sodium is the ¹³C labeled (R)-3-Hydroxybutanoic acid sodium (HY-W015851). (R)-3-Hydroxybutanoic acid sodium is a metabolite converted from acetoacetic acid catalyzed by 3-hydroxybutyrate dehydrogenase. (R)-3-Hydroxybutanoic acid sodium can function as a nutrition source, and as a precursor for vitamins, antibiotics and pheromones ^[1] ^[3].

HY-146821S

2,3-Dihydroxypropyl ((R)-2-(oleoyloxy)-3-(pentadecanoyloxy)propyl) phosphate-d7 sodium
2,3-Dihydroxypropyl ((R)-2-(oleoyloxy)-3-(pentadecanoyloxy)propyl) phosphate-d₇ (sodium) is deuterium labeled 2,3-Dihydroxypropyl ((R)-2-(oleoyloxy)-3-(pentadecanoyloxy)propyl) phosphate (sodium).

HY-A0021AS

(S,R)-Palonosetron-d3 hydrochloride
(S,R)-Palonosetron-d₃ (hydrochloride) is the deuterium labeled (S,R)-Palonosetron hydrochloride ^[1].

HY-W1002207

(5R)-Menthone-d3
(5R)-Menthone-d₃ is a deuterium labeled (5R)-Menthone.

HY-W756265

(R)-(-)-N-Boc-3-pyrrolidinol-d4
(R)-(-)-N-Boc-3-pyrrolidinol-d₄ is the deuterium labeled (R)-(-)-N-Boc-3-pyrrolidinol (HY-W001294). (R)-(-)-Boc-3-pyrrolidinol is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-W097197S

(R)-2-((R)-2-Amino-3-phenylpropanamido)-3-phenylpropanoic acid-d5
(R)-2-((R)-2-Amino-3-phenylpropanamido)-3-phenylpropanoic acid-d₅ is deuterium labeled (R)-2-((R)-2-Amino-3-phenylpropanamido)-3-phenylpropanoic acid.

HY-W401531S

(R)-3-O-Methyldopa-d3
(R)-3-O-Methyldopa-d₃ is a deuterium labeled (R)-3-O-Methyldopa, and (R)-3-O-Methyldopa is an R-enantiomer of 3-O-Methyldopa. 3-O-Methyldopa is a metabolite of L-DOPA which is formed by catechol-O-methyltransferase (COMT). 3-O-Methyldopa competitively inhibits the pharmacodynamics of L-DOPA and dopamine ^[1] .

HY-W401531S1

(R)-3-O-Methyldopa-d3 hydrochloride
(R)-3-O-Methyldopa-d₃ (hydrochloride) is a deuterium labeled (R)-3-O-Methyldopa, and (R)-3-O-Methyldopa is an R-enantiomer of 3-O-Methyldopa. 3-O-Methyldopa is a metabolite of L-DOPA which is formed by catechol-O-methyltransferase (COMT). 3-O-Methyldopa competitively inhibits the pharmacodynamics of L-DOPA and dopamine ^[1] .

HY-W700540

(R)-2-(Methyl-d3)butanoyl chloride
(R)-2-(Methyl-d₃)butanoyl chloride is the deuterium labeled (R)-2-Methylbutanoyl chloride (HY-W722288).

HY-B0072S

Tropisetron-d5

Tropisetron-d₅ (SDZ-ICS-930-d₅ (free base)) is deuterium labeled Tropisetron. Tropisetron (SDZ-ICS-930 free base) is an orally active anti-inflammatory and antiemetic agent. Tropisetron is 5-HT₃R antagonists with a K_i of 5.3 nM. Tropisetron is also a partial agonist of α7 nicotinic receptor (α7 nAChR) with an EC₅₀ of 1.3 μM. In addition, Tropisetron has antitumor and neuroprotective effects ^[1] ^[3] .

HY-W777351

Etravirine-13C3
Etravirine- ¹³C₃ (R165335- ¹³C₃) is the ¹³C-labeled Etravirine (HY-90005). Etravirine (R165335; TMC125) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used for the treatment of HIV.

HY-W778023

(R)-2-(3-Benzoylphenyl)propanoic acid-13C,d3
(R)-2-(3-Benzoylphenyl)propanoic acid- ¹³C,d₃ ((R)-(-)-Ketoprofen- ¹³C,d₃) is the deuterium labeled and ¹³C-labeled Ketoprofen-d₃-1 (HY-W322573S).

HY-177079S

Dazodeunetant
Dazodeunetant (Example 56) is a nitrogen-containing fused ring derivative. Dazodeunetant is an inhibitor of neurokinin (NK). Dazodeunetant has an IC₅₀ 0f 75.99 nM against *NK3R* in HEK293-NK3 (IP1). Dazodeunetant can be studied in research for menopausal hot flashes ^[1].

HY-144856S1

Sapropterin-d3
Sapropterin-d₃ ((6R)-BH4-d₃) is deuterium labeled Sapropterin. Sapropterin ((6R)-BH4) is an orally active phenylalanine hydroxylase (PAH) cofactor, which is effective in reducing blood phenylalanine concentrations. Sapropterin can be used in study of phenylketonuria (PKU) ^[1] .

HY-W777120

Cisapride-13C,d3
Cisapride- ¹³C,d₃ (R 51619- ¹³C,d₃) is the deuteriumand ¹³C-labeled Cisapride (HY-14149). Cisapride (R 51619) is an orally active 5-HT4 receptor agonist with an EC₅₀ value of 140 nM. Cisapride is a hERG blocker with an IC₅₀ value of 9.4 nM. Cisapride is a gastroprokinetic agent that stimulates gastrointestinal motor activity ^[1] ^[3] .

HY-17514S1

Itraconazole-d3

Itraconazole-d₃ (R51211-d₃) is the deuterium labeled Itraconazole (HY-17514) ^[1]. Itraconazole (R51211) is a triazole antifungal agent and a potent and orally active Hedgehog (Hh) signaling pathway antagonist with an IC₅₀ of ~800 nM. Itraconazole potently inhibits lanosterol 14α-demethylase (cytochrome P450 enzyme), thereby inhibits the oxidative conversion of lanosterol to ergosterol. Itraconazole has anticancer and antiangiogenic effects. Itraconazole is a oxysterol-binding protein (OSBP) inhibitor.

HY-B0399S2

L-Carnitine-13C3

L-Carnitine- ¹³C₃ ((R)-Carnitine- ¹³C₃) is the ¹³C--labeled L-Carnitine (HY-B0399). L-Carnitine ((R)-Carnitine), a highly polar, small zwitterion, is an essential co-factor for the mitochondrial β-oxidation pathway. L-Carnitine functions to transport long chain fatty acyl-CoAs into the mitochondria for degradation by β-oxidation. L-Carnitine is an antioxidant. L-Carnitine can ameliorate metabolic imbalances in many inborn errors of metabolism ^[1] ^[3].

HY-B0267BS

Oxybutynin-d5 hydrochloride

Oxybutynin-d₅ hydrochloride is deuterated labeled (R)-Oxybutynin hydrochloride (HY-B0267B). (R)-Oxybutynin hydrochloride, a (R)-isomer of Oxybutynin hydrochloride, is an orally active muscarinic receptor antagonist. (R)-Oxybutynin hydrochloride has antimuscarinic, antispasmodic and anticholinergic activity, competitively antagonizes Carbachol-induced contractions. (R)-Oxybutynin hydrochloride can be used for researching incontinence due to neurogenic bladder dysfunction ^[1] ^[3]. (R)-Oxybutynin hydrochloride is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-141723S

(4R,5R)-5-(2,4-Difluorophenyl)-4-methyl-5-(1H-1,2,4-triazol-1-ylmethyl)-2-oxazolidinone-d3
(4R,5R)-5-(2,4-Difluorophenyl)-4-methyl-5-(1H-1,2,4-triazol-1-ylmethyl)-2-oxazolidinone-d₃ is the deuterium labeled (4R,5R)-5-(2,4-Difluorophenyl)-4-methyl-5-(1H-1,2,4-triazol-1-ylmethyl)-2-oxazolidinone ^[1].

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks