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SP

" in MedChemExpress (MCE) Product Catalog:

597

Inhibitors & Agonists

2

Screening Libraries

2

Fluorescent Dye

7

Biochemical Assay Reagents

47

Peptides

2

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24

Inhibitory Antibodies

275

Natural
Products

50

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8

Isotope-Labeled Compounds

29

Antibodies

1

Click Chemistry

73

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-P2753
    Sucrose phosphorylase
    1 Publications Verification

    SP

    		 Endogenous Metabolite Others Cancer
    Sucrose phosphorylase is a bacterial transglucosidase that catalyzes the conversion of sucrose and phosphate into α-D-glucose-1-phosphate and D-fructose. The glucosylated Sucrose phosphorylase can also be hydrolyzed into α-D-glucose, or transfer the glucoyl to the hydroxyl group of the receptor, and then decomposed into new α-D-glucoside products. The enzymatic activity of base phosphorylase to substrate and product is weak .
    Sucrose phosphorylase
  • HY-110182
    SP-141
    3 Publications Verification

    		 MDM-2/p53 Cancer
    SP-141 is a specific inhibitor of MDM2. SP-141 promotes MDM2 auto-ubiquitination and degradation. SP-141 might be used for the research of pancreatic cancer and breast cancer cells .
    SP-141
  • HY-144646
    SP-471

    		Flavivirus Dengue Virus Virus Protease Infection
    SP-471 is a potent dengue virus (DENV) protease inhibitor with IC50 value of 18 μM. SP-471 inhibits both intermolecular and intramolecular protease processes of DENV .
    SP-471
  • HY-110177
    SP-100030
    1 Publications Verification

    		 NF-κB Inflammation/Immunology
    SP-100030 is a potent NF-κB and activator protein-1 (AP-1) double inhibitor (IC50s=50 and 50 nM, respectively). SP-100030 inhibits IL-2, IL-8, and TNF-alpha production in Jurkat and other T cell lines. SP-100030 decreases murine collagen-induced arthritis (CIA) .
    SP-100030
  • HY-131339
    SP-96
    2 Publications Verification

    		 Aurora Kinase Cancer
    SP-96 is a highly potent, selective and non-ATP-competitive Aurora B (IC50=0.316 nM) inhibitor and shows >2000 fold selectivity against FLT3 and KIT. SP-96 shows selective growth inhibition in NCI60 screening, incluing MDA-MD-468 (GI50=107 nM). SP-96 can be used for the research of triple negative breast cancer (TNBC) .
    SP-96
  • HY-144647
    SP inhibitor 1

    		SARS-CoV Virus Protease Infection
    SP inhibitor 1 (compound 34) is a selective SARS-CoV-2 spike protein (SP) inhibitor with an IC50 of 3.26 μM, >25 μM, >25 μM for SP, M pro and PL pro protein, respectively. SP inhibitor 1 is a vitro SARS-CoV-2 replication inhibitor at non-toxic concentrations (0.3250<5.98 μM). SP inhibitor 1 shows cellular antiviral activity .
    SP inhibitor 1
  • HY-P3258
    SP-10

    		Cholinesterase (ChE) Infection
    SP-10 is a small peptide derived from S protein with an IC50 value of 1.88 nM for blocks the interaction between S protein and ACE2. SP-10 can be used for SARS-CoV research .
    SP-10
  • HY-155176
    SP-2-225

    		HDAC Cancer
    SP-2-225 is a selective HDAC6 inhibitor. SP-2-225 enhance the production of cancer-associated antigens and macrophage antigen cross-presentation to T cells. SP-2-225 reduces the tumor volume in a syngeneic SM1 melanoma model .
    SP-2-225
  • HY-178143
    Sp1-IN-1

    		KLF Cancer
    Sp1-IN-1 is a selective specificity protein 1 (Sp1) inhibitor. Sp1-IN-1 inhibits the proliferation of Hela cells and MCF-7 cells. Sp1-IN-1 can be used to the studies of cervical cancer and breast cancer .
    Sp1-IN-1
  • HY-P11050A
    SP94

    		Apoptosis Cancer
    SP94 is a peptide ligand with high specificity for hepatocellular carcinoma cells. SP94 selectively binds to multiple hepatocellular carcinoma cell lines in vitro. SP94 inhibits tumor growth in a mouse model of hepatocellular carcinoma by promoting apoptosis and reducing angiogenesis. SP94 can be used as a specific probe for hepatocellular carcinoma imaging. SP94 is useful for hepatocellular carcinoma research .
    SP94
  • HY-137614
    Sp-GTPαS

    		Biochemical Assay Reagents Others
    Sp-GTPαS is a phosphonothioate analog of GTP. Sp-GTPαS is more metabolically stable than GTP .
    Sp-GTPαS
  • HY-137638A
    Sp-5,6-DCl-cBIMPS sodium

    SP-5,6-DCI-cBIMPS

    		 PKA Metabolic Disease
    Sp-5,6-DCl-cBIMPS sodium is a potent and specific cAMP-dependent protein kinases (cAMP-PK) activator. Sp-5,6-DCl-cBIMPS sodium stimulates insulin release. Sp-5,6-DCl-cBIMPS sodium inhibits U-46619 (HY-108566)-induced activation of Rho, Gq and G12/G13 in platelets .
    Sp-5,6-DCl-cBIMPS sodium
  • HY-137632
    Sp-8-Cl-cAMPS

    		PKA Cancer
    Sp-8-Cl-cAMPS is an analog of cAMP (HY-B1511) and a derivative of Sp-8-Cl-cAMP. Sp-8-Cl-cAMPS inhibits the growth of human leukemia cell HL-60 and colon cancer cell LS-174T, with IC50 of 8-100 μM. Sp-8-Cl-cAMPS activates the protein kinases cAKI and cAKII, with Ka of 0.25 and 3.2 μM .
    Sp-8-Cl-cAMPS
  • HY-137639
    Sp-8-Br-cGMPS

    		HCN Channel Neurological Disease
    Sp-8-Br-cGMPS is an analog of cGMP. Sp-8-Br-cGMPS is an agonist for cGMP-gated cation channels (CNG channels), with an EC50 of 106.5 μM. Sp-8-Br-cGMPS induces the currents, without the ability to stabilize the channel open state as a full agonist .
    Sp-8-Br-cGMPS
  • HY-137615
    Sp-GDPαS

    		Biochemical Assay Reagents Others
    Sp-GDPαS is a regulator of GDP-binding proteins. Sp-GDPαS is metabolically more stable than GTP .
    Sp-GDPαS
  • HY-137620
    Sp-dATPαS

    		Biochemical Assay Reagents Others
    Sp-dADPαS is a regulator of ADP-binding proteins. Sp-dADPαS is metabolically more stable than ATP .
    Sp-dATPαS
  • HY-137627
    Sp-ADPαS

    		Biochemical Assay Reagents Others
    Sp-ADPαS is a regulator of ADP-binding proteins. Sp-ADPαS is metabolically more stable than ADP .
    Sp-ADPαS
  • HY-137618
    Sp-dGTPαS

    		Biochemical Assay Reagents Others
    Sp-dGDPαS is a regulator of GDP-binding proteins. Sp-dGDPαS is metabolically more stable than GTP .
    Sp-dGTPαS
  • HY-137619
    Sp-dCTPαS

    		Biochemical Assay Reagents Others
    Sp-dCTPαS is a regulator of CTP-binding proteins. Sp-dCTPαS is metabolically more stable than CTP .
    Sp-dCTPαS
  • HY-137626
    Sp-ATPαS

    		Biochemical Assay Reagents Others
    Sp-ATPαS is a regulator of ATP-binding proteins. Sp-ATPαS is metabolically more stable than ATP .
    Sp-ATPαS
  • HY-161794
    SP3N

    		FKBP Cancer
    SP3N is a specific degrader of the prolyl isomerase FKBP12. The alkylamine of SP3N is metabolized to a reactive aldehyde (SP3CHO), which recruits the SCFFBXO22 ligase for FKBP12 degradation. SP3N may be used in research for cancer .
    SP3N
  • HY-137622
    Sp-cGMPS

    		PKG Cardiovascular Disease
    Sp-cGMPS is an activator of cGMP-dependent protein kinases (PKGs). Sp-cGMPS can be used in cardiovascular disease-related research .
    Sp-cGMPS
  • HY-161794A
    SP3N hydrochloride

    		FKBP Cancer
    SP3N hydrochloride is a specific degrader of the prolyl isomerase (FKBP12). The alkylamine of SP3N hydrochloride is metabolized to a reactive aldehyde (SP3CHO), which recruits the SCF FBXO22 ligase for FKBP12 degradation. SP3N hydrochloride may be used in research for cancer .
    SP3N hydrochloride
  • HY-137635
    Sp-6-Phe-cAMPS

    		PKA Neurological Disease
    Sp-6-Phe-cAMPS is a potent, site-selective and membrane-permeable activator of cAMP-dependent protein kinase. Sp-6-Phe-cAMPS does not activate exchange factors directly activated by cAMP and can therefore be used as an Epac negative control. Sp-6-Phe-cAMPS can be used in the study of neurodegenerative diseases .
    Sp-6-Phe-cAMPS
  • HY-137640
    Sp-8-Br-cAMPS

    		PKA Others
    Sp-8-Br-cAMPS is an analog of cAMP(HY-B1511). Sp-8-Br-cAMPS is an agonist for cAMP, which performs a protein kinase A (PKA) activating activity with EC50 of 360 nM. Sp-8-Br-cAMPS inhibits proliferation of T cells and the haemocyte non-self response in Lepidoptera larve .
    Sp-8-Br-cAMPS
  • HY-137624
    Sp-cAMPS-AM

    		PKA Others
    Sp-cAMPS-AM is an analog of cAMP. Sp-cAMPS-AM acts as the inducer of PKA activation and CREB phosphorylation, through entrance into the cell and release of its parent polar structure Sp-cAMPS .
    Sp-cAMPS-AM
  • HY-12041R
    SP600125 (Standard)

    		JNK Autophagy Apoptosis Ferroptosis Cancer
    SP600125 (Standard) is the analytical standard of SP600125. This product is intended for research and analytical applications. SP600125 is an orally active, reversible, and ATP-competitive JNK inhibitor with IC50s of 40, 40 and 90 nM for JNK1, JNK2 and JNK3, respectively. SP600125 is a potent ferroptosis inhibitor. SP600125 induces the transformation of bladder cancer cells from autophagy to apoptosis .
    SP600125 (Standard)
  • HY-161795
    SP3CHO

    		Drug Metabolite Cancer
    SP3CHO is an active metabolite generated by the metabolism of SP3N in cell culture by the action of amine oxidase. SP3CHO can induce polyubiquitination of specific proteins by recruiting the SCFFBXO22 E3 ligase complex. SP3CHO can be used in cancer therapy research .
    SP3CHO
  • HY-172942
    SP11

    		Reactive Oxygen Species (ROS) Cardiovascular Disease Neurological Disease Cancer
    SP11 is a mitochondrial reactive oxygen species (ROS) inhibitor. SP11 activates Fis1 by binding to Cys41 (IC50: 9.4 µM) and increases the translocation of Drp1 to mitochondria. SP11 can be used in studies on the protection against oxidative stress damage .
    SP11
  • HY-149324
    SP27

    		PROTACs Polo-like Kinase (PLK) Cancer
    SP27 is a PROTAC that can selective degrades PLK4, with a DC50 of 19.5 nM. SP27 can be used for the research of breast cancer .
    SP27
  • HY-100530B
    Sp-cAMPS

    		PKA Phosphodiesterase (PDE) Neurological Disease Metabolic Disease
    Sp-cAMPS, a cAMP analog, is potent activator of cAMP-dependent PKA I and PKA II. Sp-cAMPS is also a potent, competitive phosphodiesterase (PDE3A) inhibitor with a Ki of 47.6 µM. Sp-cAMPS binds the PDE10 GAF domain with an EC50 of 40 μM .
    Sp-cAMPS
  • HY-100530C
    Sp-cAMPS sodium salt

    		PKA Phosphodiesterase (PDE) Neurological Disease Metabolic Disease
    Sp-cAMPS sodium salt, a cAMP analog, is potent activator of cAMP-dependent PKA I and PKA II. Sp-cAMPS sodium salt is also a potent, competitive phosphodiesterase (PDE3A) inhibitor with a Ki of 47.6 µM. Sp-cAMPS sodium salt binds the PDE10 GAF domain with an EC50 of 40 μM .
    Sp-cAMPS sodium salt
  • HY-12041
    SP600125
    Maximum Cited Publications
    545 Publications Verification

    		 JNK Autophagy Apoptosis Ferroptosis Cancer
    SP600125 is an orally active, reversible, and ATP-competitive JNK inhibitor with IC50s of 40, 40 and 90 nM for JNK1, JNK2 and JNK3, respectively. SP600125 is a potent ferroptosis inhibitor. SP600125 induces the transformation of bladder cancer cells from autophagy to apoptosis .
    SP600125
  • HY-137640A
    Sp-8-Br-cAMPS sodium

    		PKA Inflammation/Immunology
    Sp-8-Br-cAMPS sodium is a cAMP analog, which performs a protein kinase A (PKA) activating activity with EC50 of 360 nM. Sp-8-Br-cAMPS sodium inhibits proliferation of T cells and the haemocyte non-self response in Lepidoptera larve .
    Sp-8-Br-cAMPS sodium
  • HY-137633
    Sp-8-Br-PET-cGMPS

    		PKG Neurological Disease
    Sp-8-Br-PET-cGMPS is a membrane-permeable PKG agonist and a membrane-permeable inhibitor of retinal-type cGMP-gated ion channels, as well as an activator of cGMP-dependent protein kinases I α and I β. Sp-8-Br-PET-cGMPS is resistant to mammalian cyclic nucleotide-dependent phosphodiesterases, has no metabolic side effects, and is more lipophilic and permeable than Sp-8-pCPT-cGMPS. Sp-8-Br-PET-cGMPS can be used to study the role of cGMP signaling pathways in the nervous system .
    Sp-8-Br-PET-cGMPS
  • HY-137615A
    Sp-GDPαS trisodium

    		Biochemical Assay Reagents Others
    Sp-GDPαS trisodium is a regulator of GDP-binding proteins. Sp-GDPαS trisodium is metabolically more stable than GTP .
    Sp-GDPαS trisodium
  • HY-137629
    Sp-8-pCPT-PET-cGMPS

    		PKG Cardiovascular Disease
    Sp-8-pCPT-PET-cGMPS is an activator for PKG-I. Sp-8-pCPT-PET-cGMPS can be used for research of NO/NOS/sGC/PKG-I signaling pathway in cardiac differentiation .
    Sp-8-pCPT-PET-cGMPS
  • HY-144645
    SP-471P

    		Flavivirus Dengue Virus Virus Protease DNA/RNA Synthesis Infection
    SP-471P is a potent dengue virus (DENV) protease inhibitor with EC50s of 5.9 μM, 1.4 μM, 5.1 μM and 1.7 μM for DENV1, DENV2, DENV3 and DENV4, respectively and CC50 value over 100 μM. SP-471P can reduce DENV viral RNA synthesis .
    SP-471P
  • HY-137628
    Sp-8-PIP cAMP

    		PKA Cancer
    Sp-8-PIP cAMP sodium is a non-corresponding isomer of 8-Piperidino-cAMP. 8-Piperidino-cAMP binds with high affinity to site A of the regulatory subunit of cAMP-dependent protein kinase type I (AI). Sp-8-PIP cAMP sodium can be used as an antagonist of cAMP-induced activation .
    Sp-8-PIP cAMP
  • HY-P5569
    SP-B peptide

    		Fungal Infection
    SP-B peptide is an antimicrobial peptide. SP-B peptide has antifungal activity against strains of Cryptococcus neoformans, Candida albicans and Aspergillus fumigatus
    SP-B peptide
  • HY-137638
    Sp-5,6-DCl-cBIMPS

    		PKA Metabolic Disease
    Sp-5,6-DCl-cBIMPS is a potent and specific cAMP-dependent protein kinases (cAMP-PK) activator. Sp-5,6-DCl-cBIMPS stimulates insulin release. Sp-5,6-DCl-cBIMPS inhibits U-46619 (HY-108566)-induced activation of Rho, Gq and G12/G13 in platelets .
    Sp-5,6-DCl-cBIMPS
  • HY-137613
    Sp-TTPαS

    		HIV Infection Inflammation/Immunology
    Sp-TTPαS is a competitivesterile alpha motif and HD domain containing protein 1 (SAMHD1) hydrolysis inhibitor. Sp-TTPαS competitively inhibits SAMHD1 triphosphohydrolase activity with a Ki value of 46 µM .
    Sp-TTPαS
  • HY-176005
    Sp-2'-Deoxyadenosine-5'-O-(1-thiodiphosphate) sodium

    SP-dADP-α-S sodium

    		 Drug Isomer Others
    Sp-2'-Deoxyadenosine-5'-O-(1-thiodiphosphate) (Sp-dADP-α-S) sodium is an isomer of Rp-2'-Deoxyadenosine-5'-O-(1-thiodiphosphate) sodium (HY-176004) .
    Sp-2'-Deoxyadenosine-5'-O-(1-thiodiphosphate) sodium
  • HY-160991
    Menabitan

    SP-204

    		 Phosphodiesterase (PDE) Others Neurological Disease
    Menabitan (SP-204) is an inhibitor for phosphodiesterase 9 (PDE 9), which acts as a non-opioid analgesic agent. Menabitan lowers the intraocular pressure in rabbit model .
    Menabitan
  • HY-137618A
    Sp-dGTPαS tetrasodium

    		Nucleoside Antimetabolite/Analog Infection
    Sp-dGTPαS tetrasodium is a sulfur-containing isomer of dGTP (HY-138616). Sp-dGTPαS tetrasodium inhibits SAMHD1 triphosphohydrolase activity with a Ki of 820 nM .
    Sp-dGTPαS tetrasodium
  • HY-110005
    Sp-cAMPS triethylamine

    		PKA Phosphodiesterase (PDE) Neurological Disease Metabolic Disease
    Sp-cAMPS triethylamine, a cAMP analog, is potent activator of cAMP-dependent PKA I and PKA II. Sp-cAMPS triethylamine is also a potent, competitive phosphodiesterase (PDE3A) inhibitor with a Ki of 47.6 µM. Sp-cAMPS triethylamine binds the PDE10 GAF domain with an EC50 of 40 μM .
    Sp-cAMPS triethylamine
  • HY-120994B
    Sp-8-CPT-cAMPS

    		PKA Neurological Disease Inflammation/Immunology
    Sp-8-CPT-cAMPS, a cAMP analog, is a potent and selective activator of the cAMP-dependent protein kinas A (PKA I and PKA II). Sp-8-CPT-cAMPS selects site A of RI compares to site A of RII by 153-fold and site B of RII compares to site B of RI by 59-fold .
    Sp-8-CPT-cAMPS
  • HY-16912
    Petadeferitrin

    SP-420

    		 Ferroptosis Metabolic Disease
    Petadeferitrin (SP-420) is a tridentate iron chelator belonging to the class of iron chelators, with orally activity. Petadeferitrin can be used in research related to β-thalassemia .
    Petadeferitrin
  • HY-137619A
    Sp-dCTPαS tetrasodium

    		Nucleoside Antimetabolite/Analog Infection
    Sp-dCTPαS tetrasodium is a sulfur-containing isomer of dGTP (HY-138616). Sp-dCTPαS tetrasodium inhibits SAMHD1 triphosphohydrolase activity with a Ki of 6.3 μM .
    Sp-dCTPαS tetrasodium
  • HY-137623
    Sp-cCMPS

    		Biochemical Assay Reagents Others
    Sp-cCMPS is a cCMP analog that activates the binding protein of cCMP .
    Sp-cCMPS

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