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Results for "

Nrf-2

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Keap1-Nrf2 (299) Akt (17) Aminotransferases (Transaminases) (1) AMPK (11) Amyloid-β (7) Androgen Receptor (1) Antibiotic (6) Apoptosis (96) Arenavirus (2) ASK1 (2) ATF6 (3) Atg8/LC3 (1) ATP Synthase (1) Autophagy (58) Bacterial (16) Bcl-2 Family (10) Biochemical Assay Reagents (1) Calcium Channel (3) CaMK (1) Caspase (20) CD38 (1) CDK (2) Cholinesterase (ChE) (11) COX (5) CX3CR1 (2) Cytochrome P450 (4) DAPK (2) Dengue Virus (2) Deubiquitinase (1) Dihydroorotate Dehydrogenase (2) DNA Methyltransferase (2) DNA/RNA Synthesis (1) Drug Intermediate (1) Drug Isomer (3) Drug Metabolite (5) E1/E2/E3 Enzyme (6) EGFR (1) Endogenous Metabolite (65) Enterovirus (2) Epigenetic Reader Domain (4) ERK (20) Estrogen Receptor/ERR (2) Fatty Acid Synthase (FASN) (1) Ferroptosis (32) Filovirus (2) Flavivirus (2) Fluorescent Dye (1) FOXO (1) Fungal (11) FXR (2) GABA Receptor (1) GLUT (3) Glutathione Peroxidase (7) GSK-3 (1) HDAC (5) Heme Oxygenase (HO) (18) HIF/HIF Prolyl-Hydroxylase (8) Histone Acetyltransferase (4) Histone Methyltransferase (1) HIV (11) HMG Family (2) HMG-CoA Reductase (HMGCR) (9) HSP (1) IAP (1) IKK (5) Indoleamine 2,3-Dioxygenase (IDO) (2) Influenza Virus (7) Insecticide (5) Integrin (1) Interleukin Related (16) Isotope-Labeled Compounds (27) JAK (1) JNK (6) Lactate Dehydrogenase (1) Lipoxygenase (2) LPL Receptor (3) MAGL (1) MAP3K (5) MDM-2/p53 (2) MEK (3) Melatonin Receptor (2) Microtubule/Tubulin (1) Mitochondrial Metabolism (10) Mitophagy (10) Mixed Lineage Kinase (3) MMP (11) Monoamine Oxidase (3) mTOR (4) MyD88 (2) NADPH Oxidase (1) Necroptosis (5) NF-κB (64) NO Synthase (19) NOD-like Receptor (NLR) (10) Nuclear Factor of activated T Cells (NFAT) (2) Organoid (1) Oxidative Phosphorylation (1) P2Y Receptor (2) p38 MAPK (10) p62 (3) PAI-1 (2) Parasite (6) PARP (8) PCSK9 (2) PERK (5) Phosphatase (3) Phosphodiesterase (PDE) (1) Phospholipase (1) PI3K (5) PPAR (14) Prostaglandin Receptor (3) PROTACs (1) Proton Pump (2) PTEN (1) Pyroptosis (5) Pyruvate Kinase (2) Quinone Reductase (12) RAR/RXR (7) Reactive Oxygen Species (ROS) (84) Reference Standards (58) Ribosomal S6 Kinase (RSK) (2) ROCK (1) ROS Kinase (9) SARS-CoV (5) Sirtuin (11) Small Interfering RNA (siRNA) (3) SOD (3) SphK (3) STAT (3) STING (1) Survivin (1) TGF-beta/Smad (4) TGF-β Receptor (2) Thrombin (2) TNF Receptor (10) Toll-like Receptor (TLR) (8) Topoisomerase (1) Transferrin Receptor (1) TRP Channel (2) VEGFR (1) Virus Protease (7) α-synuclein (1)
By Research Areas:	Cancer (193) Cardiovascular Disease (68) Endocrinology (13) Infection (48) Inflammation/Immunology (194) Metabolic Disease (76) Neurological Disease (113)
Click Chemistry:	Azide (1) Alkynes (2)
Oligonucleotides:	Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (2) siRNAs (3)

414

Inhibitors & Agonists

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Inhibitory Antibodies

171

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Isotope-Labeled Compounds

Antibodies

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Targets Recommended: Keap1-Nrf2

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-145879

Nrf2 activator-2	Keap1-Nrf2	Cancer
Nrf2 activator-2 (compound O15), a Osthole derivative, is a potent *Nrf2* agonist with an EC₅₀ of 2.9 μM in 293 T cells. Nrf2 activator-2 effectively inhibits the interaction between Keap1 and Nrf2, thus showing the activation effect on Nrf2. Nrf2 activator-2 shows a marked decrease in the level of ubiquitinated Nrf2 in cells .

HY-143333

Nrf2 activator-3	Keap1-Nrf2	Neurological Disease Inflammation/Immunology
Nrf2 activator-3 is a potent *Nrf2* activator. Nrf2 activator-3 is used for cerebral ischemic injury research .

HY-P10530

Nrf2 (69-84)	Keap1-Nrf2	Neurological Disease Inflammation/Immunology Cancer
Nrf2 (69-84) is a peptide fragment of Nrf2 protein that contains the key ETGE motif, which is an important region for binding to the Kelch domain of Keap1 protein. Nrf2 (69-84) can be used to study the role of Nrf2 in the development and progression of diseases, especially in cancer, neurodegenerative diseases and inflammatory diseases .

HY-146086

Nrf2 activator-4	Keap1-Nrf2 Reactive Oxygen Species (ROS)	Neurological Disease Inflammation/Immunology
Nrf2 activator-4 (Compound 20a) is a highly potent, orally active *Nrf2* activator with an EC₅₀ of 0.63 µM. Nrf2 activator-4 suppresses reactive oxygen species against oxidative stress in microglia. Nrf2 activator-4 effectively recovers the learning and memory impairment in a scopolamine-induced mouse model .

HY-149244

Nrf2 activator-7	Quinone Reductase Keap1-Nrf2	Others
Nrf2 activator-7 (Compound 12b) is a potent *Nrf2* activator and significantly activates the *Nrf2* signaling pathway.

HY-148480

Nrf2 activator-6	Quinone Reductase Keap1-Nrf2	Cardiovascular Disease
Nrf2 activator-6, a tetrahydroisoquinoline compound, is a *Nrf2* activator. Nrf2 activator-6 has an IC₅₀ of 5 nM for inhibiting the Kelch domain-Nrf2 interaction (WO2021214470A1; Example 4) .

HY-175217

Nrf2 activator-20	Keap1-Nrf2	Cardiovascular Disease Inflammation/Immunology
Nrf2 activator-20 is a potent *Nrf2* activator with anti-inflammatory and antioxidant activities. Nrf2 activator-20 activates the anti-inflammatory pathway by interfering with the Keap1-Nrf2 interaction and is beneficial in vivo. Nrf2 activator-20 can be used for the study of acute respiratory distress syndrome (ARDS) and ischemia-reperfusion injury .

HY-175548

Nrf2 activator-21	Keap1-Nrf2 Apoptosis Caspase	Neurological Disease
Nrf2 activator-21 is a *Nrf2* activator with dual antioxidant and neuroprotective properties. Nrf2 activator-21 binds to Keap1 Kelch domain and disrupts *Keap1-Nrf2* interactions and activate antioxidant defense mechanisms. Nrf2 activator-21 reduces apoptosis and decreases caspase-3 activity in the hippocampal neurons. Nrf2 activator-21 targets cerebral ischemia/reperfusion injury (CIRI) via *Nrf2* pathway activation. Nrf2 activator-21 improves neurological function, alleviates anxiety-like behavior, enhances memory in rats with 2-vessel occlusion (2VO)-induced CIRI. Nrf2 activator-21 can be used for the study of cerebral ischemia/reperfusion injury .

HY-161992

Nrf2 activator-11	Keap1-Nrf2 Apoptosis	Neurological Disease Inflammation/Immunology
Nrf2 activator-11 (compound M11) is a *Nrf2* activator with blood-brain permeability. Nrf2 activator-11 has anti-oxidation, anti-inflammation, anti-ferroptosis and anti-apoptosis. Nrf2 activator-11 can be used to study cerebral  ischemia-reperfusion (CI/R) injury models .

HY-155572

Nrf2 activator-8	Keap1-Nrf2	Inflammation/Immunology
Nrf2 activator-8 (compound 10e) is a *Nrf2* activator (EC₅₀=37.9 nM). Nrf2 activator-8 exhibits remarkable antioxidant and anti-inflammatory effects in BV-2 microglial cells. Nrf2 activator-8 can significantly restore spatial memory deficits in a mouse model of lipopolysaccharide (LPS)-induced neuroinflammation .

HY-173307

Nrf2 activator 19	Keap1-Nrf2 Apoptosis Reactive Oxygen Species (ROS)	Cardiovascular Disease
Nrf2 activator 19 is a BBB-penetrable *NRF2/HO-1* activator. Nrf2 activator 19 exerts potent antioxidant and neuroprotective effects. Nrf2 activator 19 can also effectively reduce brain damage, reduce Reactive Oxygen Species (ROS) accumulation. Nrf2 activator 19 inhibits neuronal apoptosis. Nrf2 activator 19 promotes the recovery of neurological function and motor ability. Nrf2 activator 19 shows significant potential in ischemic stroke research .

HY-124834

Nrf2 activator-10	Keap1-Nrf2 Apoptosis	Cancer
Nrf2 activator-10 (Compound AI-1) is a PI3K-dependent inducer for antioxidant response element (ARE) (EC₅₀ is 2.7 μM) and an activator for *Nrf2. Nrf2* activator-10 modifies Keap1, blocks Cul3-Keap1 ubiquitin ligase complex, activates the transcription of Nrf2. Nrf2 activator-10 protects cells from H₂O₂-induced apoptosis.

HY-169315

Nrf2 activator 17	Keap1-Nrf2	Cancer
Nrf2 activator 17 (compound 10) is an *Nrf2* activator that inhibits the interaction between Keap1 and Nrf2 with an IC₅₀ of < 0.1 pM. Additionally, Nrf2 activator 17 has an EC₅₀ of < 10 μM in HepG2 cells .

HY-146168

Nrf2 activator-5	Keap1-Nrf2	Inflammation/Immunology
Nrf2 activator-5 (compound 1) is a potent *Nrf2* activator that can attenuate H₂O₂-induced oxidative stress and LPS-stimulated inflammation in BV-2 microglial cells. Nrf2 activator-5 exhibits antioxidant and anti-inflammatory activities .

HY-156081

Nrf2 activator-9	Keap1-Nrf2 Apoptosis	Metabolic Disease
Nrf2 activator-9 (compound D-36) is an Nrf2 activator that inhibits oxidized low-density lipoprotein (oxLDL) and high glucose (HG)-induced apoptosis in HUVEC cells. Nrf2 activator-9 inhibits oxLDL and HG-induced vascular endothelial cell (VEC) injury and can effectively prevent and treat atherosclerosis .

HY-168709

Nrf2 activator 18	Keap1-Nrf2	Inflammation/Immunology
Nrf2 activator 18 (Compound 11a) is an orally active activator for *Keap1/Nrf2/HO-1* signaling pathway, that promotes the Nrf2 nuclear translocation, and enhances the antioxidant efficacy. Nrf2 activator 18 inhibits the release of IL-6 with an IC₅₀ of 4.816 μM. Nrf2 activator 18 exhibits anti-inflammatory efficacy in mouse PM2.5-induced lung injury model .

HY-145390

Nrf2 activator-1	Keap1-Nrf2	Inflammation/Immunology
Nrf2 activator-1 is a potent activator of NF-E2 related factor 2 (Nrf2). Nrf2 activator-1 has the potential for the research of COPD and other respiratory diseases, including asthma, Acute Lung Injury (ALI), Acute Respiratory Distress Syndrome (ARDS) and pulmonary fibrosis (extracted from patent WO2018109647A1) .

HY-162307

Nrf2 degrader 1	PROTACs Keap1-Nrf2	Cancer
Nrf2 degrader 1 (compound 1) is a PROTAC Nrf2 degrader with anticancer effects. Nrf2 degrader 1 inhibits cancer cells growth for A549 and LK-2 cells with IC₅₀ values of 100 nM and 40 nM, respectively .

HY-169201

Nrf2 activator-12	Keap1-Nrf2	Cancer
Nrf2 activator-12 (compund 10v) potently activates *Nrf2* (EC50=83.5 nM) and exhibits promising pharmacological properties, reversing disease progression and alleviating demyelination in an experimental autoimmune encephalomyelitis mouse model .

HY-175209

Nrf2-IN-4	Keap1-Nrf2 Ferroptosis Reactive Oxygen Species (ROS) Atg8/LC3	Cancer
Nrf2-IN-4 is a *Nrf2* inhibitor. Nrf2-IN-4 induces ferroptosis via *NRF2* inhibition. Nrf2-IN-4 disrupts cellular iron homeostasis, facilitates ferritin degradation, and ultimately triggers ferroptosis. Nrf2-IN-4 induces lysosome activation by promoting iron-dependent ROS production and lysosomal acidification. Nrf2-IN-4 demonstrates significant antitumor efficacy. Nrf2-IN-4 can be used for the study of breast cancer .

HY-149508

Nrf2-IN-3	Keap1-Nrf2 Reactive Oxygen Species (ROS)	Cancer
Nrf2-IN-3 (Compound R16) is a small-molecule *NRF2* inhibitor and increases reactive oxygen species (ROS) production. Nrf2-IN-3 selectively binds KEAP1 mutants and restores their NRF2-inhibitory function by repairing the disrupted KEAP1/NRF2 interactions, leading to proteasome-dependent NRF2 degradation in cells. Nrf2-IN-3 sensitizes KEAP1-mutated tumor cells to Cisplatin (HY-17394), Gefitinib (HY-50895), and KEAP1 G333C-mutated xenograft to Cisplatin .

HY-101025

Nrf2-IN-1 5+ Cited Publications	Keap1-Nrf2	Cancer
Nrf2-IN-1 is an inhibitor of nuclear factor-erythroid 2-related factor 2 (Nrf2). Nrf2-IN-1 is developed for the research of acute myeloid leukemia (AML) .

HY-115849

Nrf2-Activator-12G	Keap1-Nrf2	Neurological Disease
Nrf2-Activator-12G (compd 12g) is an activator of *Nrf2. Nrf2-Activator-12G induces the expression of nrf2-dependentantioxidant enzymes at both mRNA and protein levels in DAergic neuronal cell. Nrf2*-Activator-12G can used in study Parkinson’s Disease .

HY-151430

Nrf2/HO-1 activator 1	Keap1-Nrf2 ERK Akt JNK Reactive Oxygen Species (ROS)	Neurological Disease
Nrf2/HO-1 activator 1 (Compound 24) is a potent *Nrf2/HO-1* activator, neuroprotective agent. Nrf2/HO-1 activator 1 shows neuroprotective and antioxidant activities. Nrf2/HO-1 activator 1 can be used in Parkinson's disease (PD) research .

HY-151431

Nrf2/HO-1 activator 2	Keap1-Nrf2 Reactive Oxygen Species (ROS) ERK Akt JNK	Neurological Disease
Nrf2/HO-1 activator 2 (compound 13m), difluoro-substituted derivative, is a potent *Nrf2/HO-1* activator. Nrf2/HO-1 activator 2 has neuroprotective and antioxidant effects through the Nrf2/HO-1 pathway mediated by phosphorylation of ERK1/2, JNK, or Akt in PC12 cells. Nrf2/HO-1 activator 2 can be used in the research of Parkinson's disease (PD) .

HY-170867

Nrf2/HO-1 activator 3	Keap1-Nrf2 Heme Oxygenase (HO) Reactive Oxygen Species (ROS)	Cardiovascular Disease
Nrf2/HO-1 activator 3 (Compound C3a) is the activator for *Nrf2* signaling pathway that promotes the *Nrf2* translocation into nuclei and upregulates the expression of heme oxygenase-1 HO-1. Nrf2/HO-1 activator 3 inhibits the overespression of ROS and MDA in H₂O₂- or glucose-stimulated H9c2 cardiomyocytes, inhibits the cell viability and colony formation, thereby exhibiting antioxidant efficacy .

HY-144635

Nrf2-ARE/hMAO-B/QR2 modulator 1	Monoamine Oxidase Keap1-Nrf2 Reactive Oxygen Species (ROS)	Neurological Disease
Nrf2-ARE/hMAO-B/QR2 modulator 1 is a Resveratrol-based multitarget-directed ligands with IC₅₀s of 8.05, 9.83 and 0.57 μM for hMAO-B, *NRF2* and *QR2. Nrf2-ARE/hMAO-B/QR2 modulator 1 has neuroprotection, decreasing ROS* production in okadaic acid-treated mice hippocampal slices . Nrf2-ARE/hMAO-B/QR2 modulator 1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-P5909

*Keap1-Nrf2* probe**	Keap1-Nrf2	Cancer
Keap1-Nrf2 probe is a *Keap1-Nrf2* probe .

HY-147924

*Keap1-Nrf2-IN-11*	Keap1-Nrf2 NO Synthase ROS Kinase	Inflammation/Immunology
Keap1-Nrf2-IN-11 (compound 6k) is a *Keap1-Nrf2* inhibitor with K_D2 value of 0.21 nM. Keap1-Nrf2-IN-11 inhibits the productions of ROS and NO and the expression of TNF-α. Keap1-Nrf2-IN-11 relieves inflammations by increasing the Nrf2 nuclear translocation. Keap1-Nrf2-IN-11 can be used for anti-inflammatory research .

HY-151362

*Keap1-Nrf2-IN-14* 1 Publications Verification	Keap1-Nrf2 Reactive Oxygen Species (ROS)	Inflammation/Immunology
Keap1-Nrf2-IN-14 (compound 20c) is a *KEAP1-NRF2* inhibitor that effectively disrupts the *KEAP1-NRF2* interaction (IC₅₀=75 nM) with a K_d value of 24 nM for KEAP1. Keap1-Nrf2-IN-14 induces the expression of *NRF2* target genes and enhances the downstream antioxidant and anti-inflammatory activities. Keap1-Nrf2-IN-14 can be used in the study of oxidative stress-related inflammation .

HY-168526

*Keap1-Nrf2-IN-24*	Keap1-Nrf2	Inflammation/Immunology
Keap1-Nrf2-IN-24 (compound 57) is a potent *Keap1-Nrf2* inhibitor with a K_i value of 13 nM. Keap1-Nrf2-IN-24 increases the protein expression of TRXR1 and NQO1. Keap1-Nrf2-IN-24 increases the AKR1B10 mRNA expression. Keap1-Nrf2-IN-24 shows good metabolic stability .

HY-168161

*Keap1-Nrf2-IN-23*	Keap1-Nrf2	Cancer
Keap1-Nrf2-IN-23 (compound 56) is an inhibitor of the Keap1–Nrf2 PPI (IC₅₀=16.0 nM). Keap1-Nrf2-IN-23 binds to Keap1 with a K_d value of 3.07 nM. Keap1-Nrf2-IN-23 has oral activity .

HY-172598

*Keap1-Nrf2-IN-28*	Keap1-Nrf2	Inflammation/Immunology
Keap1-Nrf2-IN-28 (SG16) is an orally active *Keap1-Nrf2* inhibitor. Keap1-Nrf2-IN-28 shows antioxidant capability and induces the upregulation of *Nrf2, HO-1, GCLM, and Akr1c1. Keap1-Nrf2*-IN-28 attenuates APAP (HY-66005)-induced acute liver injury .

HY-143893

*Keap1-Nrf2-IN-6*	Keap1-Nrf2	Inflammation/Immunology
Keap1-Nrf2-IN-6 (compound 64) is a potent and selective Keap1-Nrf2 PPI (Keap1-Nrf2 protein−protein interaction) inhibitor with an IC₅₀ of 41 nM, K_d of 68 nM .

HY-146577

*Keap1-Nrf2-IN-7*	Keap1-Nrf2	Inflammation/Immunology
Keap1-Nrf2-IN-7 (compound 7v) is a potent Keap1-Nrf2 PPI (Keap1-Nrf2 protein−protein interaction) inhibitor with an IC₅₀ of 0.45 µM .

HY-147517

*Keap1-Nrf2-IN-9*	Keap1-Nrf2	Neurological Disease Inflammation/Immunology
Keap1-Nrf2-IN-9 (Compound 11) is a potent Keap1-Nrf2 PPI (Keap1-Nrf2 protein-protein interaction) inhibitor with an IC₅₀ of 0.575 μM. Keap1-Nrf2-IN-9 increases the expression of Nrf2 target genes including heme oxygenase 1 (Hmox1), glutathione S-transferase P (GstP), and glutamate-cysteine ligase catalytic (Gclc) and modulatory (Gclm) subunits. Keap1-Nrf2-IN-9 shows no cytotoxic activity in ARPE19 cells .

HY-146578

*Keap1-Nrf2-IN-8*	Keap1-Nrf2	Inflammation/Immunology
Keap1-Nrf2-IN-8 (compound 12d) is a potent Keap1-Nrf2 PPI (Keap1-Nrf2 protein−protein interaction) inhibitor with IC₅₀s of 64.5 nM and 14.2 nM for FP and TR-FRET assays, respectively. Keap1-Nrf2-IN-8 significantly increases the mRNA levels of Nrf2 downstream genes, GSTM3, HMOX2 and NQO1 .

HY-143892

*Keap1-Nrf2-IN-5*	Keap1-Nrf2	Inflammation/Immunology
Keap1-Nrf2-IN-5 (compound 1) is a potent Keap1-Nrf2 PPI (Keap1-Nrf2 protein−protein interaction) inhibitor with an IC₅₀ of 4.1 µM, K_d of 3.7 µM .

HY-150578

*Keap1-Nrf2-IN-12*	Keap1-Nrf2	Inflammation/Immunology
Keap1-Nrf2-IN-12 is a potent *Keap1-Nrf2* inhibitor with an IC₅₀ value of 2.30 µM. Keap1-Nrf2-IN-12 shows metabolic stability in human liver microsomes .

HY-162096

*Keap1-Nrf2-IN-17*	Keap1-Nrf2	Cancer
Keap1-Nrf2-IN-17 (compound 18) is a potent inhibitor of *Keap1-Nrf2* protein-protein interaction .

HY-168922

*Keap1-Nrf2-IN-25*	Keap1-Nrf2 Reactive Oxygen Species (ROS) Interleukin Related	Inflammation/Immunology
Keap1-Nrf2-IN-25 (Compound 19) is a potent *Keap1-Nrf2* inhibitor (IC₅₀ of 0.55 μM) with Keap1 binding affinity (K_d of 0.50 μM). Keap1-Nrf2-IN-25 activates *Nrf2, reduces ROS* and pro-inflammatory cytokines (IL-1β, IL-6). Keap1-Nrf2-IN-25 exerts protective effects against DSS (HY-116282)-induced colitis .

HY-139862

*Keap1-Nrf2-IN-3*	Keap1-Nrf2	Others
Keap1-Nrf2-IN-3 is a *KEAP1:NRF2* protein−protein interaction inhibitor, and with a K_d value of 2.5 nM for KEAP1 protein.

HY-145390A

*(R,R)-Nrf2* activator-1**	Keap1-Nrf2	Inflammation/Immunology
(R,R)-Nrf2 activator-1 is the enantiomer of Nrf2 activator-1. Nrf2 activator-1 is a potent activator of NF-E2 related factor 2 (Nrf2). Nrf2 activator-1 has the potential for the research of COPD and other respiratory diseases, including asthma, Acute Lung Injury (ALI), Acute Respiratory Distress Syndrome (ARDS) and pulmonary fibrosis .

HY-144099

*Keap1-Nrf2-IN-4*	E1/E2/E3 Enzyme Apoptosis	Cancer
Keap1-Nrf2-IN-4 is a potent neddylation inhibitor. Keap1-Nrf2-IN-4 exhibits potent anti-proliferation activity against MGC-803 cells (IC₅₀=2.55 µM). Keap1-Nrf2-IN-4 blocks the migration ability and induces apoptosis of gastric cancer cells. Keap1-Nrf2-IN-4 inhibits tumor growth without obvious toxicity .

HY-168065

*Keap1-Nrf2-IN-22*	Keap1-Nrf2	Inflammation/Immunology
Keap1-Nrf2-IN-22 (compound 19) is a *Keap1-Nrf2* inhibitor， with a *K_D2* value of 42.2 nM for Keap1. Keap1-Nrf2-IN-22 can be used for the study of acute lung injury (ALI) and cerebral ischemia/reperfusion (I/R) injury .

HY-P5909F

*FITC-labelled Keap1-Nrf2* probe**	Keap1-Nrf2	Others
FITC-labelled Keap1-Nrf2 probe is aFITC-labeled Keap1-Nrf2 probe (HY-P5909).

HY-159495

*Keap1-Nrf2-IN-21*	Keap1-Nrf2	Metabolic Disease Cancer
Keap1-Nrf2-IN-21 (compound 4d) is a glucose metabolism inhibitor with antitumor activity. Keap1-Nrf2-IN-21 inhibits glycolytic activity of cancer cells by targeting the glycolytic pathway, especially by affecting the *Keap1-Nrf2* signaling pathway, thereby inhibiting tumor growth. Keap1-Nrf2-IN-21 exhibits cytotoxicity against the HEC1A cell line (IC₅₀=2.60 μM) .

HY-157929

*Keap1-Nrf2-IN-19*	Keap1-Nrf2	Inflammation/Immunology Cancer
Keap1-Nrf2-IN-19 (compound 33) is an oral active Keap1-Nrf2 protein–protein interaction (PPI) inhibitor with the K_d value of 0.0014 μM. Keap1-Nrf2-IN-19 exhibits less than 50% inhibition at 30 μM against hERG and 10 μM against CYPs .

HY-147548

*Keap1-Nrf2-IN-10*	Reactive Oxygen Species (ROS) Quinone Reductase	Others
Keap1-Nrf2-IN-10 (compound 15) is a potent NQO1 inducer. Keap1-Nrf2-IN-10 inhibits oxidative stress by decreasing the levels of MDA, ROS, NQO1 in the liver for gamma-irradiated mice. Keap1-Nrf2-IN-10 improves the survival of gamma-irradiated mice .

HY-173187

*Keap1-Nrf2-IN-27*	Keap1-Nrf2	Inflammation/Immunology
Keap1-Nrf2-IN-27 (compound 1C) is a inhibitor of Keap1-Nrf2 protein-protein interaction (PPI) with *K_D2* value of 0.119 μM. Keap1-Nrf2-IN-27 suppresses the expression of pro-inflammatory cytokine TNF-α and IL-6 in the LPS-induced RAW264.7 cell model .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-122550

Artemisitene 1 Publications Verification	Piscidia erythrina L. Terpenoids Sesquiterpenes Source classification Plants Compositae	Keap1-Nrf2 Topoisomerase Apoptosis
Artemisitene, a natural derivative of Artemisinin, is a *Nrf2* activator with antioxidant and anticancer activities. Artemisitene activates Nrf2 by decreasing Nrf2 ubiquitination and increasing its stability ^[2].

HY-131592

Tricetin 1 Publications Verification	Flavonols Structural Classification Flavonoids Cupressaceae Thuja occidentalisLinn. Neurological Disease Classification of Application Fields Source classification Plants Inflammation/Immunology Disease Research Fields	Apoptosis Keap1-Nrf2
Tricetin is a potent competitive inhibitor of the *Keap1-Nrf2* Protein Protein Interaction (PPI). Tricetin protects against 6-OHDA-induced neurotoxicity in Parkinson's disease model by activating Nrf2/HO-1 signaling pathway and preventing mitochondria-dependent apoptosis pathway .

HY-W009731

Dibenzoylmethane	Structural Classification Classification of Application Fields Leguminosae Ketones, Aldehydes, Acids Source classification Metabolic Disease Plants Glycyrrhiza uralensis Fisch. Disease Research Fields	Keap1-Nrf2
Dibenzoylmethane, a minor ingredient in licorice, activates *Nrf2* and prevents various cancers and oxidative damage. Dibenzoylmethane, an analog of curcumin, results in dissociation from Keap1 and nuclear translocation of Nrf2 .

HY-N7617

Toralactone 1 Publications Verification	Structural Classification Microorganisms Classification of Application Fields Source classification Phenols Polyphenols Caesalpiniaceae Cassia obtusifolia (L.) H. S. Irwin & Barneby Plants Disease Research Fields Cancer	Keap1-Nrf2
Toralactone, isolated from Cassia obtusifolia, mediates hepatoprotection via an Nrf2-dependent anti-oxidative mechanism .

HY-19543

Brusatol 30+ Cited Publications NSC 172924	Structural Classification Simaroubaceae Classification of Application Fields Terpenoids Source classification Diterpenoids Plants Disease Research Fields Brucea javanica (L.) Merr. Cancer	Keap1-Nrf2 Apoptosis
Brusatol (NSC?172924) is a unique inhibitor of the *Nrf2* pathway that sensitizes a broad spectrum of cancer cells to Cisplatin and other chemotherapeutic agents. Brusatol enhances the efficacy of chemotherapy by inhibiting the Nrf2-mediated defense mechanism. Brusatol can be developed into an adjuvant chemotherapeutic agent . Brusatol increases cellular apoptosis ^[2].

HY-N0414

Trigonelline 5 Publications Verification Trigenolline	Structural Classification Classification of Application Fields Source classification Pyridine Alkaloids Metabolic Disease Plants Endogenous metabolite Alkaloids Microorganisms other families Leguminosae Trigonella foenum-graecum Linn. Disease Research Fields	Endogenous Metabolite Ferroptosis Apoptosis HIV Bacterial Fungal
Trigonelline is an alkaloid with potential antidiabetic activity that can be isolated from Trigonella foenum-graecum L or Leonurus artemisia. Trigonelline is a potent *Nrf2* inhibitor that blocks Nrf2-dependent proteasome activity, thereby enhancing apoptosis in pancreatic cancer cells. Trigonelline also has anti-HSV-1, antibacterial, and antifungal activity and induces ferroptosis.

HY-N0415

Trigonelline chloride 5 Publications Verification Trigonelline hydrochloride	Infection Alkaloids Structural Classification Erythrophleum fordii Oliv. Classification of Application Fields Labiatae Source classification Pyridine Alkaloids Metabolic Disease Plants Disease Research Fields	Endogenous Metabolite Ferroptosis Apoptosis HIV Bacterial Fungal
Trigonelline chloride is an alkaloid with potential antidiabetic activity that can be isolated from Trigonella foenum-graecum L or Leonurus artemisia. Trigonelline chloride is a potent *Nrf2* inhibitor that blocks Nrf2-dependent proteasome activity, thereby enhancing apoptosis in pancreatic cancer cells. Trigonelline chloride also has anti-HSV-1, antibacterial, and antifungal activity, and induces ferroptosis.

HY-N6929

Angelic acid	Structural Classification Ketones, Aldehydes, Acids Source classification Umbelliferae Plants Echinacea angustifolia DC.	Others
Angelic acid is a ferroptosis inducer, targeting *NRF2* degradation. Angelic acid binds to NRF2 protein and promotes NRF2 degradation via ubiquitination-proteasome pathway, relieves the inhibitory effect of NRF2 on oxidative stress and lipid peroxidation. Then, Angelic acid induces ferroptosis in tumor cells. Angelic acid can enhance the accumulation of intracellular reactive oxygen species (ROS), upregulate ferroptosis-related markers CHAC1 and PTGS2, and synergize with ferroptosis inducers to enhance anti-tumor effects. Angelic acid also has the activity of scavenging UVA-induced ROS in vitro, inhibiting skin fibroblast senescence and extracellular matrix degradation. Angelic Acid helps wound healing with sedative activity ^[2].

HY-N15660

Azafrin	Structural Classification Ketones, Aldehydes, Acids Centranthera grandiflora Benth. Source classification Orobanchaceae Plants	Keap1-Nrf2 Heme Oxygenase (HO)
Azafrin, a carotenoid, is one of the most abundant active ingredients in C. grandiflora. Azafrin increases HO-1, NQO1, and *Nrf2* expression. Azafrin shows cardioprotective effect against myocardial injury via activation of the Nrf2-ARE pathway. Azafrin can be used for research of cardiovascular diseases .

HY-W009731R

Dibenzoylmethane (Standard)	Structural Classification Leguminosae Ketones, Aldehydes, Acids Source classification Plants Glycyrrhiza uralensis Fisch.	Reference Standards Keap1-Nrf2
Dibenzoylmethane (Standard) is the analytical standard of Dibenzoylmethane. This product is intended for research and analytical applications. Dibenzoylmethane, a minor ingredient in licorice, activates Nrf2 and prevents various cancers and oxidative damage. Dibenzoylmethane, an analog of curcumin, results in dissociation from Keap1 and nuclear translocation of Nrf2 .

HY-N0643

Carnosol 10+ Cited Publications	Structural Classification Classification of Application Fields Paramacrolobium coeruleum (Taub.) J.Léonard Food Preservation Research Source classification Plants Agricultural Research Terpenoids Labiatae Phenols Polyphenols Diterpenoids Disease Research Fields Cancer	Ribosomal S6 Kinase (RSK) Keap1-Nrf2 Endogenous Metabolite
Carnosol is a potent Ribosomal S6 Kinase *(RSK2)* inhibitor that could be useful for treating gastric cancer, with an IC₅₀ of ~5.5 μM . Carnosol, a *Nrf2* activator, increases the nuclear levels of Nrf2 and can promote the expression of heme oxygenase 1 (HMOX1) ^[2] .

HY-N0414R

Trigonelline (Standard) Trigenolline (Standard)	Alkaloids Structural Classification Microorganisms other families Leguminosae Source classification Pyridine Alkaloids Plants Endogenous metabolite Trigonella foenum-graecum Linn.	Endogenous Metabolite Ferroptosis Apoptosis HIV Bacterial Fungal Reference Standards
Trigonelline (Standard) is the analytical standard of Trigonelline. This product is intended for research and analytical applications. Trigonelline is an alkaloid with potential antidiabetic activity that can be isolated from Trigonella foenum-graecum L or Leonurus artemisia. Trigonelline is a potent Nrf2 inhibitor that blocks Nrf2-dependent proteasome activity, thereby enhancing apoptosis in pancreatic cancer cells. Trigonelline also has anti-HSV-1, antibacterial, and antifungal activity and induces ferroptosis.

HY-N0415R

Trigonelline chloride (Standard) Trigonelline hydrochloride (Standard)	Alkaloids Structural Classification Erythrophleum fordii Oliv. Labiatae Source classification Pyridine Alkaloids Plants	Endogenous Metabolite Ferroptosis Apoptosis HIV Bacterial Fungal Reference Standards
Trigonelline (chloride) (Standard) is the analytical standard of Trigonelline (chloride). This product is intended for research and analytical applications. Trigonelline chloride is an alkaloid with potential antidiabetic activity that can be isolated from Trigonella foenum-graecum L or Leonurus artemisia. Trigonelline chloride is a potent Nrf2 inhibitor that blocks Nrf2-dependent proteasome activity, thereby enhancing apoptosis in pancreatic cancer cells. Trigonelline chloride also has anti-HSV-1, antibacterial, and antifungal activity, and induces ferroptosis.

HY-N6929R

Angelic acid (Standard)	Structural Classification Ketones, Aldehydes, Acids Source classification Umbelliferae Plants Echinacea angustifolia DC.	Reference Standards Others
Angelic acid (Standard)) is the analytical standard of Angelic acid (HY-N6929). This product is intended for research and analytical applications. Angelic acid is a ferroptosis inducer, targeting *NRF2* degradation. Angelic acid binds to NRF2 protein and promotes NRF2 degradation via ubiquitination-proteasome pathway, relieves the inhibitory effect of NRF2 on oxidative stress and lipid peroxidation. Then, Angelic acid induces ferroptosis in tumor cells. Angelic acid can enhance the accumulation of intracellular reactive oxygen species (ROS), upregulate ferroptosis-related markers CHAC1 and PTGS2, and synergize with ferroptosis inducers to enhance anti-tumor effects. Angelic acid also has the activity of scavenging UVA-induced ROS in vitro, inhibiting skin fibroblast senescence and extracellular matrix degradation. Angelic Acid helps wound healing with sedative activity ^[2].

HY-N3260

Methyllucidone	Structural Classification Natural Products Source classification Plants Lauraceae	Reactive Oxygen Species (ROS) Keap1-Nrf2 PI3K
Methyllucidone is a neuroprotective agent and an antioxidant that can be isolated from Lindera erythrocarpa Makino. Methyllucidone inhibits the ROS production, and activates antioxidant signaling pathways that include *Nrf-2* and PI3K .

HY-N2292

Kinsenoside 4 Publications Verification	Structural Classification Natural Products Classification of Application Fields Orchidaceae Plants Anoectochilus Inflammation/Immunology Disease Research Fields	Keap1-Nrf2 Apoptosis
Kinsenoside is the main active ingredient of the genus plant, and has various biological activities. Kinsenoside and Nrf2 depend on the protection of nuclear cells (NPCs), which significantly reduces their ability to survive. Kinsenoside Active NPC Medium AKT-ERK1/2-Nrf2 Signal passage, Prevent physical decline, aging, harmonious physical function impairment. Kinsenoside can improve the puncture guide model for intermediate vertebral wall discharge (IDD).

HY-13755

Sulforaphane 55+ Cited Publications	Structural Classification Natural Products other families Classification of Application Fields Source classification Plants Inflammation/Immunology Disease Research Fields	HDAC Keap1-Nrf2 Apoptosis Bcl-2 Family Caspase Reactive Oxygen Species (ROS)
Sulforaphane is an orally active inducer of the *Keap1/Nrf2/ARE* pathway. Sulforaphane promotes the transcription of tumor-suppressing proteins and effectively inhibits the activity of HDACs. Through the activation of the Keap1/Nrf2/ARE pathway and further induction of HO-1 expression, Sulforaphane protects the heart. Sulforaphane suppresses high glucose-induced pancreatic cancer through AMPK-dependent signal transmission. Sulforaphane exhibits both anticancer and anti-inflammatory properties ^[2] .

HY-N12486

Isofalcarintriol	Structural Classification Natural Products Source classification Decachaeta ovatifolia (DC.) R.M.King & H.Rob. Plants Umbelliferae	Keap1-Nrf2 ATP Synthase
Isofalcarintriol is a *NRF2* activator and selective inhibitor of the mitochondrial ATP synthase. Isofalcarintriol can be used for aging study .

HY-N15190

Sesaminol	Structural Classification Acanthaceae Source classification Lignans Justicia procumbens Linnaeus Phenylpropanoids Plants	Quinone Reductase Keap1-Nrf2 Reactive Oxygen Species (ROS)
Sesaminol is an orally active activator for *Nrf2-ARE* pathway, that promotes the the nuclear translocation of Nrf2 and enhances the NQO1 expression, thereby enhances the cell's defense against oxidative stress. Sesaminol inhibits 6-OHDA (HY-B1081)-induced ROS production and apoptosis in cell SH-SY5Y. Sesaminol exhibits neuroprotective efficacy against Rotenone (HY-B1756)-induced Parkinson's disease .

HY-N0509

Astilbin 5 Publications Verification	Flavanonols Structural Classification Flavonoids Microorganisms other families Classification of Application Fields Source classification Phenols Polyphenols Plants Disease Research Fields Cancer	Keap1-Nrf2 TNF Receptor NF-κB
Astilbin is a flavonoid compound and enhances *NRF2* activation. Astilbin also suppresses TNF-α expression and NF-κB activation.

HY-N1244

Sarmentosin Sarmentosine; Sarmentosine (glycoside)	Structural Classification Natural Products Animals Source classification Saccharides Monosaccharides	Keap1-Nrf2 mTOR Apoptosis
Sarmentosin is an activator of *Nrf2. Sarmentosin inhibits mTOR* signaling and induces autophagy-dependent apoptosis in human HCC cells .

HY-N0643R

Carnosol (Standard)	Structural Classification Paramacrolobium coeruleum (Taub.) J.Léonard Terpenoids Labiatae Source classification Phenols Polyphenols Diterpenoids Plants	Reference Standards Ribosomal S6 Kinase (RSK) Keap1-Nrf2 Endogenous Metabolite
Carnosol (Standard) is the analytical standard of Carnosol. This product is intended for research and analytical applications. Carnosol is a potent Ribosomal S6 Kinase (RSK2) inhibitor that could be useful for treating gastric cancer, with an IC₅₀ of ~5.5 μM . Carnosol, a Nrf2 activator, increases the nuclear levels of Nrf2 and can promote the expression of heme oxygenase 1 (HMOX1) ^[2] .

HY-120912

Gingerenone A	Zingiber officinale Roscoe Structural Classification Source classification Phenols Polyphenols Plants Zingiberaceae	Keap1-Nrf2 Glutathione Peroxidase Ferroptosis
Gingerenone A is an Nrf2-Gpx4 activator that can induce Ferroptosis in liver damage with oral activity. Gingerenone A has anti-inflammatory, anti-diabetic, anti-tumor, and pro-aging effects in mice ^[2] .

HY-N0806

Sweroside 2 Publications Verification	Filago spathulata Presl. Structural Classification Monophenols Classification of Application Fields Labiatae Phenols Metabolic Disease Plants Disease Research Fields	Keap1-Nrf2 AMPK Sirtuin NF-κB NOD-like Receptor (NLR) Pyroptosis Apoptosis Autophagy PARP
Sweroside is an iridoid glycoside that targets multiple targets, including the Keap1/Nrf2 axis, NLRP3 inflammasome, SIRT1, NF-κB, AMPK/mTOR pathway, and caspase family. Sweroside promotes Nrf2 nuclear translocation by competitively binding to Keap1. Sweroside also inhibits oxidative stress and NLRP3-mediated pyroptosis by activating Nrf2, inhibits NF-κB inflammatory pathway by activating SIRT1, and promotes autophagy and induces caspase-dependent apoptosis via the AMPK/mTOR pathway. Sweroside has antioxidant, anti-inflammatory, anti-apoptotic, and lipid metabolism regulating activities, and can be used in the research of myocardial ischemia-reperfusion injury, leukemia, acute lung injury, non-alcoholic fatty liver disease, and other fields ^[2] .

HY-N3847

Eriodictyol-7-O-glucoside Eriodictyol 7-O-β-D-glucoside	Structural Classification Flavonoids Classification of Application Fields Labiatae Flavonones Source classification Phenols Polyphenols Metabolic Disease Plants Disease Research Fields Petalostemun purpureum	Keap1-Nrf2
Eriodictyol-7-O-glucoside (Eriodictyol 7-O-β-D-glucoside), a flavonoid, is an *Nrf2* activator. Eriodictyol-7-O-glucoside exhibits significant scavenging effects on both hydroxyl radicals and superoxide anions, with IC₅₀ values of 0.28 mM and 0.30 mM, respectively. Eriodictyol-7-O-glucoside increases the nuclear localization of *Nrf2* and induces the expression of the *Nrf2/ARE*-dependent genes. Eriodictyol-7-O-glucoside provides protection against oxygen and glucose deprivation (OGD)-induced oxidative insult. Eriodictyol-7-O-glucoside demonstrates neuroprotective efficacy in a rat model of focal cerebral ischemia (MCAO). Eriodictyol-7-O-glucoside can be used for the study of stroke ^[2] .

HY-N0651

Spinosin 1 Publications Verification	Structural Classification Flavonoids Flavones Ziziphus jujuba Mill. var. spinosa (Bunge) Hu ex H.F.Chow. Source classification Phenols Polyphenols Plants Rhamnaceae	Amyloid-β
Spinosyn is a kind of effective C-saccharide, which has a protective effect. Spinosyn is active through Nrf2/HO-1 pathway inhibition Aβ_1-42's production and combination ^[2] ^{[3 ]}.

HY-N1902

4-Hydroxyphenylacetic acid	Structural Classification Human Gut Microbiota Metabolites Monophenols Classification of Application Fields Source classification Phenols Metabolic Disease Plants Compositae Endogenous metabolite Erythrina latissima E. Mey. Disease Research Fields	Keap1-Nrf2 Endogenous Metabolite
4-hydroxyphenylacetic acid, a major microbiota-derived metabolite of polyphenols, is involved in the antioxidative action. 4-hydroxyphenylacetic acid induces expression of *Nrf2* .

HY-N0606

Ginsenoside Rh3 1 Publications Verification	Panax ginseng C. A. Meyer Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Plants Inflammation/Immunology Disease Research Fields Araliaceae	Quinone Reductase Keap1-Nrf2
Ginsenoside Rh3 is a bacterial metabolite of Ginsenoside Rg5. Ginsenoside Rh3 treatment in human retinal cells induces *Nrf2* activation.

HY-N0892

AKBA 3 Publications Verification Acetyl-11-keto-β-boswellic acid	Triterpenes Structural Classification Classification of Application Fields Terpenoids Boswellia serrata Plants Burseraceae Disease Research Fields Cancer	HIF/HIF Prolyl-Hydroxylase Reactive Oxygen Species (ROS) Endogenous Metabolite
AKBA (Acetyl-11-keto-β-boswellic acid) is an active triterpenoid compound from the extract of Boswellia serrate and a novel Nrf2 activator.

HY-N1902R

4-Hydroxyphenylacetic acid (Standard)	Structural Classification Human Gut Microbiota Metabolites Monophenols Source classification Phenols Plants Compositae Endogenous metabolite Erythrina latissima E. Mey.	Reference Standards Keap1-Nrf2 Endogenous Metabolite
4-Hydroxyphenylacetic acid (Standard) is the analytical standard of 4-Hydroxyphenylacetic acid. This product is intended for research and analytical applications. 4-hydroxyphenylacetic acid, a major microbiota-derived metabolite of polyphenols, is involved in the antioxidative action. 4-hydroxyphenylacetic acid induces expression of *Nrf2* . IC₅₀ & Target:Nrf2 In Vivo: 4-Hydroxyphenylacetic acid (6, 12, or 25 mg/kg) increases Nrf2 translocation to the nucleus and enhances the activity of phase II and antioxidant enzymes. The protein levels of nuclear Nrf2 are increased by 170% and 230% in pre-treated 12 and 25 mg/kg 4-Hydroxyphenylacetic acid groups, respectively, compared with the control group.The 4-Hydroxyphenylacetic acid pretreatment at a final dose of 25 mg/kg markedly and selectively up-regulated the target genes of phase II enzymes and resulted in higher up-regulation than that of the control group by 270%, 400%, and 500% or UGT1A1, UGT1A9, and SULT2A1, respectively. 4-Hydroxyphenylacetic acid also suppresses the expression of CYP2E1 .

HY-N4068

Glucoraphanin 5+ Cited Publications	Structural Classification Cruciferous vegetables Classification of Application Fields Other Alkaloids Source classification Glucosinolates Plants Brassicaceae Disease Research Fields Cancer	Reactive Oxygen Species (ROS) Endogenous Metabolite
Glucoraphanin, a natural glucosinolate found in cruciferous vegetable, is a stable precursor of the Nrf2 inducer sulforaphane, which possesses antioxidant, anti-inflammatory, and anti-carcinogenic effects.

HY-N0826

Corynoline 5 Publications Verification	Alkaloids Structural Classification other families Neurological Disease Classification of Application Fields Source classification Plants Isoquinoline Alkaloids Disease Research Fields Cancer	Cholinesterase (ChE) Keap1-Nrf2
Corynoline is a reversible and noncompetitive acetylcholinesterase (AChE) inhibitor with an IC₅₀ of 30.6 μM . Corynoline exhibits anti-inflammatory activity by activating *Nrf2* ^[2].

HY-N6953

Garcinone D 3 Publications Verification	Structural Classification Xanthones Guttiferae Source classification Phenols Polyphenols Garcinia mangostana Linn. Plants	STAT Keap1-Nrf2 Reactive Oxygen Species (ROS)
Garcinone D is an activator of the STAT3/Cyclin D1 and *Nrf2/HO-1* pathways, and an inhibitor of *CDK2/CyclinE1* (IC₅₀ for CDK2/CyclinE1 is 28.23 μM). Garcinone D promotes neural stem cell proliferation by activating STAT3 phosphorylation and Cyclin D1 expression and enhancing the Nrf2/HO-1 signaling pathway. In addition, Garcinone D blocks the tumor cell cycle by inhibiting CDK2/CyclinE1. Garcinone D can promote the proliferation of C17.2 neural stem cells and inhibit prostate and breast cancer ^[2].

HY-N2157

Pteryxin 1 Publications Verification (+)-Pteryxin	Structural Classification Source classification Coumarins Phenylpropanoids Umbelliferae Plants Achillea atrata L.	Cholinesterase (ChE) NF-κB NOD-like Receptor (NLR) Keap1-Nrf2 Reactive Oxygen Species (ROS) Nuclear Factor of activated T Cells (NFAT) p38 MAPK
Pteryxin ((+)-Pteryxin) is an orally active multi-target inhibitor that targets NF-κB, MAPK, NLRP3 inflammasome, and *Nrf2/ARE* pathways. Pteryxin is also a BChE inhibitor (IC₅₀=12.96 μg/mL) with a low inhibitory efficiency on AChE. Pteryxin inhibits the Ca ²⁺-calcineurin-NFATc1 pathway by blocking NF-κB/MAPK signaling, inhibiting NLRP3 inflammasome activation, and reducing ROS generation, and activates Nrf2-mediated antioxidant enzyme expression. Pteryxin has anti-inflammatory, antioxidant, and osteoclastogenesis inhibitory activities. Pteryxin can be used in the study of inflammatory diseases, osteoporosis, diabetes, and Alzheimer's disease ^[2] .

HY-N0385

Gomisin J 3 Publications Verification	Cardiovascular Disease Structural Classification Monophenols Classification of Application Fields Source classification Lignans Phenols Phenylpropanoids Plants Schisandraceae Schisandra chinensis (Turcz.) Baill. Disease Research Fields	NO Synthase AMPK CaMK NF-κB Keap1-Nrf2
Gomisin J is a Schisandra chinensis-derived lignan that can inhibit multiple targets such as eNOS, AMPK (LKB1, CaMKIIβ), fetuin-A, NF-κB, *Nrf2/HO-1, and can pass through the blood-brain barrier. Gomisin J increases NO bioavailability by activating eNOS, regulates lipid metabolism by activating the AMPK* pathway, inhibits fetuin-A and NF-κB to exert anti-inflammatory effects, and activates Nrf2/HO-1 to enhance antioxidant capacity. Gomisin J has the activities of anti-hypertension, regulating liver lipid metabolism, and reducing cerebral ischemia-reperfusion injury, and can be used for research on hypertension, non-alcoholic fatty liver disease, cerebral ischemia-reperfusion injury, etc ^[2] .

HY-D0885

Phosphocreatine Creatine phosphate; Creatinephosphoric acid	Structural Classification Animals Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite MAP3K Akt Mitochondrial Metabolism ERK Apoptosis ROS Kinase
Phosphocreatine (creatine phosphate) is an organic compound found in vertebrate skeletal muscles. Phosphocreatine enhances antioxidant activity, and activates the TAK1 pathway to protect the heart. Phosphocreatine normalizing mitochondrial function and reducing oxidative stress via Akt mediated Nrf2/HO-1 pathway. Phosphocreatine provides renal protection by suppressing Apoptosis and ROS (Reactive Oxygen Species) generation through ERK mediated mediated Nrf-2/HO-1 pathway. ^[2] .

HY-D0885C

Phosphocreatine dipotassium Creatine phosphate dipotassium; Creatinephosphoric acid dipotassium	Structural Classification Animals Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite MAP3K Akt Mitochondrial Metabolism ERK Apoptosis ROS Kinase
Phosphocreatine (creatine phosphate) is an organic compound found in vertebrate skeletal muscles. Phosphocreatine enhances antioxidant activity, and activates the TAK1 pathway to protect the heart. Phosphocreatine normalizing mitochondrial function and reducing oxidative stress via Akt mediated Nrf2/HO-1 pathway. Phosphocreatine provides renal protection by suppressing Apoptosis and ROS (Reactive Oxygen Species) generation through ERK mediated mediated Nrf-2/HO-1 pathway. ^[2] .

HY-N0806R

Sweroside (Standard)	Filago spathulata Presl. Structural Classification Monophenols Labiatae Phenols Plants	Reference Standards Keap1-Nrf2 AMPK Sirtuin NF-κB NOD-like Receptor (NLR) Pyroptosis Apoptosis Autophagy PARP
Sweroside (Standard) is the analytical standard of Sweroside (HY-N0806). This product is intended for research and analytical applications. Sweroside is an iridoid glycoside that targets multiple targets, including the Keap1/Nrf2 axis, NLRP3 inflammasome, SIRT1, NF-κB, AMPK/mTOR pathway, and caspase family. Sweroside promotes Nrf2 nuclear translocation by competitively binding to Keap1. Sweroside also inhibits oxidative stress and NLRP3-mediated pyroptosis by activating Nrf2, inhibits NF-κB inflammatory pathway by activating SIRT1, and promotes autophagy and induces caspase-dependent apoptosis via the AMPK/mTOR pathway. Sweroside has antioxidant, anti-inflammatory, anti-apoptotic, and lipid metabolism regulating activities, and can be used in the research of myocardial ischemia-reperfusion injury, leukemia, acute lung injury, non-alcoholic fatty liver disease, and other fields ^[2] .

HY-N11004

Erinacine C 1 Publications Verification	Structural Classification Human Gut Microbiota Metabolites Microorganisms Terpenoids Source classification Diterpenoids Endogenous metabolite	NF-κB Keap1-Nrf2 Heme Oxygenase (HO)
Erinacine C is the inhibitor for NF-κB signaling pathway and the activator for *Nrf2* signaling pathway. Erinacine C exhibits antioxidant, neuroprotective and anti-inflammatory effects ^[2].

HY-13755A

(R)-Sulforaphane 1 Publications Verification L-Sulforaphane	Structural Classification Natural Products other families Classification of Application Fields Source classification Plants Disease Research Fields Cancer	Keap1-Nrf2 Bcl-2 Family Caspase Reactive Oxygen Species (ROS) NF-κB
(R)-Sulforaphane (L-Sulforaphane) is a orally active, potent inducer of the Keap1/Nrf2/ARE pathway, exhibiting antioxidant and anticancer activities. (R)-Sulforaphane primarily functions by upregulating phase II detoxifying enzymes in cells, aiding in the removal of carcinogens and combating oxidative stress. (R)-Sulforaphane is capable of modulating gene expression, influencing various signaling pathways, including *Nrf2, NF-κB, and AP-1*. (R)-Sulforaphane can be used in studies of tumor biology, antioxidant defense mechanisms, as well as inflammation and immune responses ^[2] .

HY-N11657

Sanggenon A Sanggenone A	Structural Classification Flavonoids Source classification Morus alba L. Plants Moraceae Other Flavonoids	NF-κB Keap1-Nrf2
Sanggenon A (Sanggenone A) exerts anti-inflammatory effects by regulating NF-κB and HO-1/Nrf2 signaling pathways in BV2 and RAW264.7 cells. Sanggenon A markedly inhibits the Lipopolysaccharide (LPS; HY-D1056)-induced production of nitric oxide .

HY-N0745

Senkyunolide I	Natural Products Classification of Application Fields Source classification Dicerothamnus rhinocerotis Plants Umbelliferae Disease Research Fields Inflammation/Immunology	Caspase
Senkyunolide I, isolated from Ligusticum chuanxiong Hort, is an anti-migraine compound. Senkyunolide I protects rat brain against focal cerebral ischemia-reperfusion injury by up-regulating p-Erk1/2, Nrf2/HO-1 and inhibiting caspase 3 ^[2].

HY-N10313

Dehydrobruceine B	Structural Classification Natural Products Microorganisms Source classification	Bcl-2 Family Keap1-Nrf2 Apoptosis
Dehydrobruceine B, a quassinoid, can be isolated from Brucea javanica. Dehydrobruceine B shows a synergistic effect with Cisplatin (HY-17394) to induce apoptosis via mitochondrial method. Dehydrobruceine B increases apoptosis-inducing factor (AIF) and Bax expression and suppresses *Keap1-Nrf2* .

HY-124941

7-Deacetylgedunin	Structural Classification Natural Products Toona sinensis (A. Juss.) Roem. Source classification Plants Meliaceae	Keap1-Nrf2 Reactive Oxygen Species (ROS)
7-Deacetylgedunin is an activator of *Keap1/Nrf2/HO-1. 7-Deacetylgedunin alleviates mice mortality induced by LPS. 7-Deacetylgedunin inhibits Keap1* expression and suppresses macrophage proliferation. 7-Deacetylgedunin suppresses inflammation in vivo and in vitro .

HY-D0885B

Phosphocreatine disodium 2 Publications Verification Disodium creatine phosphate	Structural Classification Classification of Application Fields Source classification Metabolic Disease Amino acids Endogenous metabolite Disease Research Fields	Endogenous Metabolite MAP3K Akt Mitochondrial Metabolism ERK Apoptosis ROS Kinase
Phosphocreatine (disodium) is an organic compound found in vertebrate skeletal muscles. Phosphocreatine (disodium) enhances antioxidant activity, and activates the TAK1 pathway to protect the heart. Phosphocreatine (disodium) normalizing mitochondrial function and reducing oxidative stress via Akt mediated Nrf2/HO-1 pathway. Phosphocreatine (disodium) provides renal protection by suppressing Apoptosis and ROS (Reactive Oxygen Species) generation through ERK mediated mediated Nrf-2/HO-1 pathway. ^[2] .

HY-B1328R

Pyridoxine (Standard) Pyridoxol (Standard)	Structural Classification Natural Products Microorganisms Source classification Disease markers Nervous System Disorder Endogenous metabolite Cardiovascular System Disorder	Reference Standards Endogenous Metabolite Keap1-Nrf2
Pyridoxine (Standard) is the analytical standard of Pyridoxine. This product is intended for research and analytical applications. Pyridoxine (Pyridoxol) is a pyridine derivative. Pyridoxine exerts antioxidant effects in cell model of Alzheimer's disease via the Nrf-2/HO-1 pathway. In Vitro: Pyridoxine exerts a protective potential against AD, attenuates ROS levels, decreases the expressions of cytoplasmic Nrf2, and upregulates whole-cell HO-1 expression .

HY-N7029

3',4',5',5,7-Pentamethoxyflavone	Structural Classification Flavonoids Classification of Application Fields Flavones Leguminosae Source classification Bauhinia championii (Benth.) Benth. Plants Disease Research Fields Cancer	Others
3',4',5',5,7-Pentamethoxyflavone, a natural flavonoid extracted from Rutaceae plants, sensitizes chemoresistant cancer cells to chemotherapeutic agents by inhibition of Nrf2 pathway .

HY-B1971

Deltamethrin 1 Publications Verification Decamethrin	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields Cancer	Endogenous Metabolite Calcium Channel Caspase Apoptosis Bcl-2 Family NF-κB Interleukin Related
Deltamethrin (Decamethrin) is an orally active synthetic pyrethroid insecticide. Deltamethrin induces oxidative stress and results in inflammation and apoptosis via inhibiting Nrf2/HO-1 pathway. Deltamethrin has an anticancer effect by inducing apoptosis. Deltamethrin can be used extensively in pest control ^[2] .

HY-120912R

Gingerenone A (Standard)	Zingiber officinale Roscoe Structural Classification Source classification Phenols Polyphenols Plants Zingiberaceae	Keap1-Nrf2 Glutathione Peroxidase Ferroptosis
Gingerenone A (Standard) is the analytical standard of Gingerenone A. This product is intended for research and analytical applications. Gingerenone A is an Nrf2-Gpx4 activator that can induce Ferroptosis in liver damage with oral activity. Gingerenone A has anti-inflammatory, anti-diabetic, anti-tumor, and pro-aging effects in mice ^[2] .

HY-D0885D

Phosphocreatine disodium hydrate 2 Publications Verification	Structural Classification Animals Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite MAP3K Akt Mitochondrial Metabolism ERK Apoptosis ROS Kinase
Phosphocreatine (disodium hydrate) is an organic compound found in vertebrate skeletal muscles. Phosphocreatine (disodium hydrate) enhances antioxidant activity, and activates the TAK1 pathway to protect the heart. Phosphocreatine (disodium hydrate) normalizing mitochondrial function and reducing oxidative stress via Akt mediated Nrf2/HO-1 pathway. Phosphocreatine (disodium hydrate) Phosphocreatine (disodium hydrate) provides renal protection by suppressing Apoptosis and ROS (Reactive Oxygen Species) generation through ERK mediated mediated Nrf-2/HO-1 pathway. ^[2] .

Cat. No.	Product Name	Chemical Structure

HY-17376S

Ezetimibe-d4
Ezetimibe-d₄ is the deuterium labeled Ezetimibe. Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator.

HY-17363S

Dimethyl fumarate-d6
Dimethyl fumarate-d₆ is a deuterium labeled Dimethyl fumarate. Dimethyl fumarate is a nuclear factor (erythroid-derived)-like 2 (Nrf2) pathway activator and induces upregulation of antioxidant gene expression ^[2] .

HY-N1902S

4-Hydroxyphenylacetic acid-d6
4-Hydroxyphenylacetic acid-d₆ is the deuterium labeled 4-Hydroxyphenylacetic acid. 4-hydroxyphenylacetic acid, a major microbiota-derived metabolite of polyphenols, is involved in the antioxidative action. 4-hydroxyphenylacetic acid induces expression of Nrf2 .

HY-14664CS

(3S,5R)-Fluvastatin-d6 sodium
(3S,5R)-Fluvastatin-d₆ (sodium)?is the deuterium labeled (3S,5R)-Fluvastatin sodium. Fluvastatin is a first fully synthetic, competitive?HMG-CoA reductase?inhibitor with an IC₅₀?of 8 nM. Fluvastatin protects vascular smooth muscle cells against oxidative stress through the Nrf2-dependent antioxidant pathway .

HY-17376S1

Ezetimibe-d4-1
Ezetimibe-d₄-1 is deuterium labeled Ezetimibe. Ezetimibe (SCH 58235) is a potent cholesterol absorption inhibitor. Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator.

HY-W701218

Sulforaphane-d8

Sulforaphane-d₈ is the deuterium labeled Sulforaphane (HY-13755). Sulforaphane is an orally active inducer of the Keap1/Nrf2/ARE pathway. Sulforaphane promotes the transcription of tumor-suppressing proteins and effectively inhibits the activity of HDACs. Through the activation of the Keap1/Nrf2/ARE pathway and further induction of HO-1 expression, Sulforaphane protects the heart. Sulforaphane suppresses high glucose-induced pancreatic cancer through AMPK-dependent signal transmission. Sulforaphane exhibits both anticancer and anti-inflammatory properties ^[2] .

HY-B1971S1

Deltamethrin-d6
Deltamethrin-d₆ (Decamethrin-d₆) is deuterium labeled Deltamethrin. Deltamethrin (Decamethrin) is an orally active synthetic pyrethroid insecticide. Deltamethrin induces oxidative stress and results in inflammation and apoptosis via inhibiting Nrf2/HO-1 pathway. Deltamethrin has an anticancer effect by inducing apoptosis. Deltamethrin can be used extensively in pest control ^[2] .

HY-14664DS

(3S,5R)-Fluvastatin-d6
(3S,5R)-Fluvastatin-d₆ is the deuterium labeled (3S,5R)-Fluvastatin sodium. Fluvastatin is a first fully synthetic, competitive?HMG-CoA reductase?inhibitor with an IC₅₀?of 8 nM. Fluvastatin protects vascular smooth muscle cells against oxidative stress through the Nrf2-dependent antioxidant pathway .

HY-112675S

4-Octyl itaconate-13C5-1
4-Octyl itaconate- ¹³C₅-1 is ¹³C-labeled 4-Octyl itaconate (HY-112675). Itaconate is an anti-inflammatory metabolite that activates *Nrf2* via alkylation of KEAP1.

HY-N1902S1

4-Hydroxyphenylacetic acid-d4
4-Hydroxyphenylacetic acid-d₄ is the deuterium labeled 4-Hydroxyphenylacetic acid . 4-hydroxyphenylacetic acid, a major microbiota-derived metabolite of polyphenols, is involved in the antioxidative action. 4-hydroxyphenylacetic acid induces expression of Nrf2 ^[2].

HY-W704787

Monoethyl fumarate-d5
Monoethyl fumarate-d₅ is the deuterium labeled Monoethyl fumarate (HY-W019696). Monoethyl fumarate is the monoethyl ester form of Fumaric acid (HY-W015883). Monoethyl fumarate is the activator for Nrf2. Monoethyl fumarate is a kind of effective preservative and polymerization agent for macromolecular material ^[2].

HY-N0761AS

trans-Isoferulic acid-d3

trans-Isoferulic acid-d₃ is the deuterium labeled trans-Isoferulic acid . trans-Isoferulic acid (trans-3-Hydroxy-4-methoxycinnamic acid) is an aromatic acid isolated from the roots of Clematis florida var. plena. trans-Isoferulic acid exhibits anti-inflammatory activity ^[2].trans-isoferulic acid suppresses NO and PGE2 production through the induction of Nrf2-dependent heme oxygenase-1 (HO-1) .

HY-D0205AS2

Carbocisteine-d3
Carbocisteine-d₃ (Carbocysteine-d₃) is deuterium labeled Carbocisteine. Carbocisteine is an orally active mucolytic agent. Carbocisteine attenuates the phosphorylation of NF-κB p65 and *ERK1/2. Carbocisteine modulates Nrf2/HO-1* and NFκB interplay. Carbocisteine inhibits Apoptosis. Carbocisteine is used in chronic obstructive pulmonary disease (COPD) research ^[2] .

HY-B0916S

Propoxur-d3

Propoxur-d₃ is the deuterated form of Propoxur (HY-B0916). Propoxur is a reversible, competitive, orally active AChE inhibitor that can cross the blood-brain barrier. Propoxur inhibits AChE activity to induce neurotoxicity, while promoting MMP-2 expression and enhancing tumor cell migration and invasion by inducing intracellular ROS generation and activating the ERK/Nrf2 signaling pathway. On the one hand, Propoxur inhibits AChE, leading to acetylcholine accumulation and causing neurological dysfunction; on the other hand, it promotes Nrf2 nuclear translocation through ROS-dependent ERK1/2 phosphorylation, and upregulates MMP-2 and other invasion-related proteins. Propoxur is also a carbamate insecticide used to combat turf, forestry, and household pests ^[2] .

HY-17376S3

Ezetimibe-13C6
Ezetimibe- ¹³C₆ (SCH 58235- ¹³C₆) is the ¹³C-labeled Ezetimibe (HY-17376). Ezetimibe (SCH 58235) is a potent cholesterol absorption inhibitor. Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator.

HY-D0205AS1

Carbocisteine-13C3-1

Carbocisteine- ¹³C₃-1 (Carbocysteine- ¹³C₃-1) is ¹³C labeled Carbocisteine. Carbocisteine is an orally active mucolytic agent. Carbocisteine attenuates the phosphorylation of NF-κB p65 and ERK1/2. Carbocisteine modulates Nrf2/HO-1 and NFκB interplay. Carbocisteine inhibits Apoptosis. Carbocisteine is used in chronic obstructive pulmonary disease (COPD) research ^[2] .

HY-12519S

Oltipraz-d3
Oltipraz-d₃ is the deuterium labeled Oltipraz. Oltipraz has an inhibitory effect on HIF-1α activation in a time-dependent manner, completely abrogating HIF-1α induction at ≥10 μM concentrations, the IC50 of Oltipraz for HIF-1α inhibition is 10 μM. Oltipraz is a potent Nrf2 activator.

HY-17363S1

Dimethyl fumarate-d2

Dimethyl fumarate-d₂ is the deuterium labeled Dimethyl fumarate . Dimethyl fumarate (DMF) is an orally active and brain-penetrant Nrf2 activator and induces upregulation of antioxidant gene expression. Dimethyl fumarate induces necroptosis in colon cancer cells through GSH depletion/ROS increase/MAPKs activation pathway, and also induces cell autophagy. Dimethyl fumarate can be used for multiple sclerosis research ^[2] .

HY-N5060S

Estragole-d4

Estragole-d₄ is deuterated labeled Estragole (HY-N5060). Estragole (4-Allylanisole) is a relatively nontoxic volatile terpenoid ether and major component of the essential oil from many plants. Estragole significantly triggers Apoptosis, suppresses LPS-induced intracellular ROS production. Estragole activats Nrf-2 and regulates NF-κB. Estragole has anti-toxoplasma, anti-inflammatory, anti-edema, antioxidant and immunomodulatory properties. Estragole blocks DRG neuron excitability. Estragole has improves gastric ulcer activity ^[2] [10] .

HY-14649S5

Retinoic acid-d3

Retinoic acid-d₃ is the deuterium labeled Retinoic acid (HY-14649). Retinoic acid is a metabolite of vitamin A that plays important roles in cell growth, differentiation, and organogenesis. Retinoic acid is a natural agonist of RAR nuclear receptors, with IC₅₀s of 14 nM for RARα/β/γ. Retinoic acid bind to PPARβ/δ with Kd of 17 nM. Retinoic acid acts as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha ^[2] .

HY-14649S6

Retinoic acid-d3-1

Retinoic acid-d₃-1 is the deuterium labeled Retinoic acid (HY-14649). Retinoic acid is a metabolite of vitamin A that plays important roles in cell growth, differentiation, and organogenesis. Retinoic acid is a natural agonist of RAR nuclear receptors, with IC₅₀s of 14 nM for RARα/β/γ. Retinoic acid bind to PPARβ/δ with Kd of 17 nM. Retinoic acid acts as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha ^[2] .

HY-14649S2

11-cis-Retinoic Acid-d5

11-cis-Retinoic Acid-d₅ is the deuterium labeled Retinoic acid. Retinoic acid is a metabolite of vitamin A that plays important roles in cell growth, differentiation, and organogenesis. Retinoic acid is a natural agonist of RAR nuclear receptors, with IC50s of 14 nM for RARα/β/γ. Retinoic acid bind to PPARβ/δ with Kd of 17 nM. Retinoic acid acts as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha[1][2].

HY-14649S4

Retinoic acid-d5

Retinoic acid-d₅ is the the deuterium labeled Retinoic acid (HY-14649). Retinoic acid is a metabolite of vitamin A that plays important roles in cell growth, differentiation, and organogenesis. Retinoic acid is a natural agonist of RAR nuclear receptors, with IC₅₀s of 14 nM for RARα/β/γ. Retinoic acid bind to PPARβ/δ with K_d of 17 nM. Retinoic acid acts as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha ^[2] .

HY-W747703

Hippuric acid-13C6

Hippuric acid- ¹³C₆ (Benzoylglycine- ¹³C₆) is ¹³C labeled Hippuric acid. Hippuric Acid is an orally active metabolite. Hippuric Acid can be produced by intestinal microorganisms from the metabolism of polyphenols, benzoic acid. Hippuric Acid decreases NRF2, MMP9 and leads to ROS accumulation. Hippuric Acid activates TGFβ/SMAD signaling. Hippuric Acid improves hyperuricemia and colitis. Hippuric Acid can also be used in cardiovascular disease research ^[2] . .

HY-14649S3

Retinoic acid-d6

Retinoic acid-d₆ is the deuterium labeled Retinoic acid[1]. Retinoic acid is a metabolite of vitamin A that plays important roles in cell growth, differentiation, and organogenesis. Retinoic acid is a natural agonist of RAR nuclear receptors, with IC50s of 14 nM for RARα/β/γ. Retinoic acid bind to PPARβ/δ with Kd of 17 nM. Retinoic acid acts as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha[2][3][4][5][6][7].

HY-N0005S1

Curcumin-d3

Curcumin-d₃ (Diferuloylmethane-d₃ ) is deuterium labeled Curcumin (HY-N0005). Curcumin (Diferuloylmethane), a natural phenolic compound, is a p300/CREB-binding protein-specific inhibitor of acetyltransferase, represses the acetylation of histone/nonhistone proteins and histone acetyltransferase-dependent chromatin transcription. Curcumin is a photosensitizer against microorganisms. Curcumin shows inhibitory effects on NF-κB and MAPKs, and has diverse pharmacologic effects including anti-inflammatory, antioxidant, antiproliferative and antiangiogenic activities. Curcumin induces stabilization of Nrf2 protein through Keap1 cysteine modification.

HY-N0005S

Curcumin-d6

Curcumin-d₆ (Diferuloylmethane-d₆ ) is deuterium labeled Curcumin (HY-N0005). Curcumin (Diferuloylmethane), a natural phenolic compound, is a p300/CREB-binding protein-specific inhibitor of acetyltransferase, represses the acetylation of histone/nonhistone proteins and histone acetyltransferase-dependent chromatin transcription. Curcumin is a photosensitizer against microorganisms. Curcumin shows inhibitory effects on NF-κB and MAPKs, and has diverse pharmacologic effects including anti-inflammatory, antioxidant, antiproliferative and antiangiogenic activities. Curcumin induces stabilization of Nrf2 protein through Keap1 cysteine modification.

HY-16561S1

Resveratrol-13C6

Resveratrol- ¹³C₆ is the ¹³C-labeled Resveratrol. Resveratrol (trans-Resveratrol; SRT501), a natural polyphenolic phytoalexin that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol (SRT 501) has a wide spectrum of targets including mTOR, JAK, β-amyloid, Adenylyl cyclase, IKKβ, DNA polymerase. Resveratrol also is a specific SIRT1 activator ^[2] . Resveratrol is a potent pregnane X receptor (PXR) inhibitor . Resveratrol is an Nrf2 activator, ameliorates aging-related progressive renal injury in mice model . Resveratrol increases production of NO in endothelial cells .

HY-16561S

Resveratrol-d4

Resveratrol-d₄ is the deuterium labeled Resveratrol. Resveratrol (trans-Resveratrol; SRT501), a natural polyphenolic phytoalexin that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol (SRT 501) has a wide spectrum of targets including mTOR, JAK, β-amyloid, Adenylyl cyclase, IKKβ, DNA polymerase. Resveratrol also is a specific SIRT1 activator ^[2] . Resveratrol is a potent pregnane X receptor (PXR) inhibitor . Resveratrol is an Nrf2 activator, ameliorates aging-related progressive renal injury in mice model . Resveratrol increases production of NO in endothelial cells .

HY-100573S

Necrosulfonamide-d4

Necrosulfonamide-d₄ is the deuterium labeled Necrosulfonamide (HY-100573). Necrosulfonamide is a MLKL and Gasdermin D (GSDMD) inhibitor, capable of separately inhibiting necroptosis and pyroptosis of cells. Necrosulfonamide does not affect the activation of upstream signals, but specifically inhibits the downstream executor oligomerization step. Necrosulfonamide reduces the expression of the key kinases NLRP3 and caspase-1 involved in necroptosis and pyroptosis, activate the Nrf2 pathway and the downstream antioxidant enzymes, and also downregulates a variety of inflammatory factors. Necrosulfonamide plays significant roles in various diseases such as neurodegenerative diseases (such as Parkinson’s disease), tissue damage and ischemia-reperfusion injury, inflammatory bowel disease, osteoarthritis and fracture repair, and hair loss by regulating two important programmed necrosis pathways.

HY-B1328S1

Pyridoxine-d3
Pyridoxine-d3 is a deuterium labeled Pyridoxine. Pyridoxine (Pyridoxol) is a pyridine derivative. Pyridoxine exerts antioxidant effects in cell model of Alzheimer's disease via the Nrf-2/HO-1 pathway ^[2].

HY-N0682S1

Pyridoxine-d2 hydrochloride
Pyridoxine-d₂ (hydrochloride) is the deuterium labeled Pyridoxine hydrochloride. Pyridoxine hydrochloride is a pyridine derivative. Pyridoxine (Pyridoxol; Vitamin B6) exerts antioxidant effects in cell model of Alzheimer's disease via the Nrf-2/HO-1 pathway.

HY-B1328S2

Pyridoxine-d2
Pyridoxine-d₂ (Pyridoxol-d₂) is deuterium labeled Pyridoxine. Pyridoxine (Pyridoxol) is a pyridine derivative. Pyridoxine exerts antioxidant effects in cell model of Alzheimer's disease via the Nrf-2/HO-1 pathway.

HY-B1328S3

Pyridoxine-13C4
Pyridoxine- ¹³C₄ (Pyridoxol- ¹³C₄) is ¹³C labeled Pyridoxine. Pyridoxine (Pyridoxol) is a pyridine derivative. Pyridoxine exerts antioxidant effects in cell model of Alzheimer's disease via the Nrf-2/HO-1 pathway.

HY-N0682S

Pyridoxine-d3 hydrochloride
Pyridoxine-d₃ (hydrochloride) is the deuterium labeled Pyridoxine hydrochloride. Pyridoxine hydrochloride (Pyridoxol; Vitamin B6) is a pyridine derivative. Pyridoxine (Pyridoxol; Vitamin B6) exerts antioxidant effects in cell model of Alzheimer's disease via the Nrf-2/HO-1 pathway.

HY-B1328S

Pyridoxine-d5
Pyridoxine-d₅ (Pyridoxol-d₅) is a deuterium labeled Pyridoxine (HY-B1328). Pyridoxine (Pyridoxol) is a pyridine derivative. Pyridoxine exerts antioxidant effects in cell model of Alzheimer's disease via the Nrf-2/HO-1 pathway.

HY-N0682S3

Pyridoxine-13C4 hydrochloride
Pyridoxine- ¹³C₄ (hydrochloride) is the ¹³C-labeled Pyridoxine (hydrochloride). Pyridoxine hydrochloride (Pyridoxol; Vitamin B6) is a pyridine derivative. Pyridoxine (Pyridoxol; Vitamin B6) exerts antioxidant effects in cell model of Alzheimer's disease via the Nrf-2/HO-1 pathway.

HY-N0682S2

Pyridoxine-d5 hydrochloride
Pyridoxine-d₅ (hydrochloride) is the deuterium labeled Pyridoxine hydrochloride . Pyridoxine hydrochloride (Pyridoxol;Vitamin B6) is a pyridine derivative. Pyridoxine (Pyridoxol;Vitamin B6) exerts antioxidant effects in cell model of Alzheimer's disease via the Nrf-2/HO-1 pathway ^[2].

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