2. NF-κB
  3. Keap1-Nrf2
  4. Nrf2 activator-20

Nrf2 activator-20 is a potent Nrf2 activator with anti-inflammatory and antioxidant activities. Nrf2 activator-20 activates the anti-inflammatory pathway by interfering with the Keap1-Nrf2 interaction and is beneficial in vivo. Nrf2 activator-20 can be used for the study of acute respiratory distress syndrome (ARDS) and ischemia-reperfusion injury.

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Nrf2 activator-20 Chemical Structure

Nrf2 activator-20 Chemical Structure

CAS No. : 89883-16-9

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Nrf2 activator-20 Related Antibodies

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Description

Nrf2 activator-20 is a potent Nrf2 activator with anti-inflammatory and antioxidant activities. Nrf2 activator-20 activates the anti-inflammatory pathway by interfering with the Keap1-Nrf2 interaction and is beneficial in vivo. Nrf2 activator-20 can be used for the study of acute respiratory distress syndrome (ARDS) and ischemia-reperfusion injury[1].

In Vitro

Nrf2 activator-20 (Compound AP9) (1 μM, 2 h) strongly induces the Nrf2 pathway in both LPS stimulated and non-stimulated RAW cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Nrf2 activator-20 Related Antibodies

Western Blot Analysis[1]

Cell Line: RAW264.7 cells
Concentration: 1 μM
Incubation Time: 2 h
Result: Induced nuclear translocation of Nrf2 significantly while inducing HO-1 expression at nanomolar concentrations.
In Vivo

Nrf2 activator-20 (Compound AP9) (0.78 mg/kg, i.p., single dose) significantly alleviated the liver injury in mice in the liver ischemia-reperfusion injury model[1].
Nrf2 activator-20 (0.78 mg/kg, i.p., single dose) alleviate the lung injury in the mice model induced by E. coli[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Warm liver ischemia/reperfusion injury model established in C57BL/6J mice (9-14 weeks old, 27 g)[1]
Dosage: 0.78 mg/kg
Administration: Intraperitoneal injection (i.p.), single dose prior to surgery
Result: Significantly reduced plasma ALT and AST as well as hepatocellular injury.
Animal Model: Lung injury model induced by E. coli treatment established in 11–12 week old male C57BL/6 mice[1]
Dosage: 0.78 mg/kg
Administration: Intraperitoneal injection (i.p.), single dose
Result: Able to improve oxygenation during E. coli-induced lung injury.
Molecular Weight

360.83

Formula

C7H5Br3O2
CAS No.
SMILES

O=C1C(Br)=C(Br)C(O)(C)C=C1Br
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Purity & Documentation
References
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Nrf2 activator-20 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nrf2 activator-2089883-16-9Keap1-Nrf2ARDSanti-inflammationzebrafishischemia-reperfusion injurymiceInhibitorinhibitorinhibit

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