Search Result

Pathways Recommended:	NF-κB

Results for "

NF-κB Activity

" in MedChemExpress (MCE) Product Catalog:

By Targets:	NF-κB (378) 5 alpha Reductase (2) 5-HT Receptor (1) Acyltransferase (1) Adenosine Receptor (6) Adrenergic Receptor (9) Akt (49) Aminotransferases (Transaminases) (1) AMPK (4) Amyloid-β (7) Antibiotic (15) AP-1 (3) Apoptosis (158) Aryl Hydrocarbon Receptor (1) Aurora Kinase (2) Autophagy (47) Bacterial (41) Bcl-2 Family (12) Biochemical Assay Reagents (1) Btk (1) c-Kit (1) c-Met/HGFR (1) Calcium Channel (13) CaMK (1) Cannabinoid Receptor (1) Caspase (21) CCR (1) CDK (10) Cholinesterase (ChE) (1) CMV (1) Constitutive Androstane Receptor (2) COX (61) CRM1 (1) Cryptochrome (2) CXCR (4) Cyclin G-associated Kinase (GAK) (1) Cytochrome P450 (9) Dengue Virus (2) DNA/RNA Synthesis (4) Dopamine β-hydroxylase (2) Drug Isomer (1) Drug Metabolite (1) E1/E2/E3 Enzyme (7) EGFR (1) Endogenous Metabolite (47) Enterovirus (2) Epigenetic Reader Domain (4) ERK (33) Estrogen Receptor/ERR (4) Eukaryotic Initiation Factor (eIF) (2) Factor Xa (2) FAK (2) Ferroptosis (15) Flavivirus (1) FLT3 (6) FOXO (1) Fungal (13) Glucocorticoid Receptor (1) GLUT (6) Glutathione Peroxidase (3) Glutathione S-transferase (1) Glycosidase (1) GlyT (1) GSK-3 (4) HBV (3) HCV (1) HDAC (8) HIF/HIF Prolyl-Hydroxylase (7) Histone Acetyltransferase (4) Histone Demethylase (2) HIV (5) HSP (4) HSV (3) IGF-1R (2) IKK (17) Indoleamine 2,3-Dioxygenase (IDO) (1) Influenza Virus (12) Insecticide (1) Insulin Receptor (2) Integrin (1) Interleukin Related (38) IRAK (15) Isotope-Labeled Compounds (19) JAK (5) JNK (32) Keap1-Nrf2 (31) Lactate Dehydrogenase (2) Leukotriene Receptor (4) Lipoxygenase (3) MALT1 (1) MAP3K (2) MAP4K (1) MDM-2/p53 (6) Microtubule/Tubulin (3) Mitochondrial Metabolism (1) Mitophagy (11) Mixed Lineage Kinase (1) MMP (16) Molecular Glues (3) Monoamine Oxidase (3) mTOR (11) MyD88 (12) Na+/K+ ATPase (3) NO Synthase (42) NOD-like Receptor (NLR) (11) Nuclear Factor of activated T Cells (NFAT) (3) Nucleoside Antimetabolite/Analog (1) Opioid Receptor (6) Oxidative Phosphorylation (3) P-glycoprotein (1) p38 MAPK (59) PAI-1 (2) PAK (4) Parasite (23) PARP (3) PERK (3) PGC-1α (4) Phosphatase (5) Phosphodiesterase (PDE) (8) Phytohormone (3) PI3K (23) PKA (1) PKC (1) Potassium Channel (14) PPAR (13) Prostaglandin Receptor (1) PROTACs (3) Proteasome (12) PTEN (1) Pyroptosis (5) RANKL/RANK (3) Ras (1) Reactive Oxygen Species (40) Reference Standards (9) Ribosomal S6 Kinase (RSK) (4) RIP kinase (2) RSV (1) SARS-CoV (2) Ser/Thr Protease (1) Sigma Receptor (1) Sirtuin (1) SOD (4) Sodium Channel (2) STAT (17) STING (4) Succinate Dehydrogenase (2) Syk (1) TGF-beta/Smad (4) TGF-β Receptor (2) TNF Receptor (43) Toll-like Receptor (TLR) (17) Topoisomerase (3) Tyrosinase (6) VEGFR (5) Virus Protease (1) Wnt (3) β-catenin (3)
By Research Areas:	Cancer (292) Cardiovascular Disease (51) Endocrinology (16) Infection (88) Inflammation/Immunology (350) Metabolic Disease (49) Neurological Disease (65)
Click Chemistry:	Alkynes (1)
Oligonucleotides:	Solvents (1) Emulsifiers (1)

508

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

285

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Oligonucleotides

Targets Recommended: NF-κB

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-155998

NF-κB-IN-11	NF-κB	Inflammation/Immunology
NF-κB-IN-11 (Compound 3i) is a *NF-κB* inhibitor. NF-κB-IN-11 inhibits TNF-α induced activation of NF-κB pathway, and inhibits nuclear translocation of NF-κB. NF-κB-IN-11 down-regulates the expression levels of phosphor-IKK, IκBα, and NF-κB p65. NF-κB-IN-11 has anti-inflammatory activity, and alleviates dextran sulfate sodium-induced colitis in mice. NF-κB-IN-11 (p.o.) shows a MTD more than 1852 mg/kg in mice acute toxicity assay .

HY-138537

NF-κB-IN-1 2 Publications Verification	IKK	Cancer
NF-κB-IN-1, a 4-arylidene crucumin analogue, is a potent NF-κB signaling pathway inhibitor. NF-κB-IN-1 directly inhibits IKK to block NF-κB activation. NF-κB-IN-1 effectively inhibits the viability of lung cancer cells and attenuates the clonogenic activity of A549 cells .

HY-144765

NF-κB-IN-4 1 Publications Verification	NF-κB Apoptosis	Neurological Disease Inflammation/Immunology
NF-κB-IN-4 (compound 17) is a potent and BBB-penetrated *NF-κB* pathway inhibitor with blood brain barrier (BBB) permeability. NF-κB-IN-4 exhibits potential anti-neuroinflammatory activity with low toxicity. NF-κB-IN-4 can block the activation and phosphorylation of IκBα, reduce expression of NLRP3, and thus inhibit NF-κB activation. NF-κB-IN-4 can be used for neuroinflammation related diseases research .

HY-19498

WAY-204688 SIM-688	NF-κB	Inflammation/Immunology
WAY-204688 is an estrogen receptor (ER-α) selective, orally active inhibitor of *NF-κB* transcriptional activity with an IC₅₀ of 122 ± 30 nM for NF-κB-luciferase (NF-κB-luc) in HAECT-1 cells.

HY-126026

NF-κB-IN-17	NF-κB	Inflammation/Immunology
NF-κB-IN-17 (Zinc5) is a *NF-κB* inhibitor. NF-κB-IN-17 inhibits TNF-α-induced NF-κB DNA binding activity in C2C12 cells .

HY-170659

NF-κB-IN-18	NF-κB	Inflammation/Immunology
NF-κB-IN-18 (Compound 5k) is an orally active *NF-κB* inhibitor. NF-κB-IN-18 inhibits phosphorylation of p65. NF-κB-IN-18 exhibits potent anti-inflammatory activity in Xylene-induced ear edema mice .

HY-149838

NF-κB-IN-9	NF-κB	Cancer
NF-κB-IN-9 is a nuclear factor kappa B (NF-κB) targeting sonosensitizer (λex/λem=489/628 nm). NF-κB-IN-9 exhibits strong inhibition on NF-κB signaling due to its two resveratrol units in one molecule. NF-κB-IN-9 has anti-tumor activity and shows remarkable sonocytotoxicity against cancer cells. NF-κB-IN-9 has biosafety in eenograft mice model.

HY-147836

Akt/NF-κB/JNK-IN-1	Akt NF-κB JNK TNF Receptor COX	Inflammation/Immunology
Akt/NF-κB/JNK-IN-1 (Compound 2i) is an inhibitor of Akt, *NF-κB* and JNK signaling pathways. Akt/NF-κB/JNK-IN-1 inhibits nitric oxide production with an IC₅₀ of 3.15 μM. Akt/NF-κB/JNK-IN-1 shows anti-inflammatory activities .

HY-172201

NF-κB-IN-19	NF-κB Reactive Oxygen Species Autophagy Apoptosis HIF/HIF Prolyl-Hydroxylase Akt STAT PI3K	Inflammation/Immunology Cancer
NF-κB-IN-19 (Compound 8) is an *NF-κB* inhibitor. NF-κB-IN-19 effectively induces DNA damage, promotes the generation of ROS, and induces autophagy and apoptosis through the NF-κB signaling pathway in tumor cells. In addition, NF-κB-IN-19 can inhibit the levels of VEGF and HIF-1α, and exert antiproliferative activity in tumor cells through the PI3K/AKT and STAT-3 pathways. NF-κB-IN-19 can effectively overcome cisplatin resistance and has anti-tumor activity .

HY-149248

NF-κB-IN-8	NF-κB	Inflammation/Immunology
NF-κB-IN-8 competitively antagonizes LPS binding to MD-2. NF-κB-IN-8 reduces the expression of inflammatory factors by binding to MD-2. NF-κB-IN-8 also inhibits ALP activity. NF-κB-IN-8 can be used for the research of inflammation such as acute lung injury (ALI) .

HY-146058

NF-κB/PON1-IN-1	NF-κB Reactive Oxygen Species	Cancer
NF-κB/PON1-IN-1 (Compound 16) is a *NF-κB/PON1* pathway inhibitor. NF-κB/PON1-IN-1 has antioxidant (IC₅₀ = 45.76 µM) and hepatoprotective activities .

HY-147972

NF-κB/MAPK-IN-1	NF-κB p38 MAPK NO Synthase COX	Inflammation/Immunology
NF-κB/MAPK-IN-1 (compound 11a) is a potent inhibitor of *NF-κB* and MAPK pathway. NF-κB/MAPK-IN-1 shows inhibitory activity against NO production, with an IC₅₀ of 6.96 µM. NF-κB/MAPK-IN-1 suppresses LPS-induced iNOS, COX-2, ERΚ and P38 signaling activation. NF-κB/MAPK-IN-1 can prevent LPS induced inflammatory response in macrophages. NF-κB/MAPK-IN-1 can be used for rheumatoid arthritis (RA) research .

HY-162316

NF-κB-IN-15	NF-κB	Inflammation/Immunology
NF-κB-IN-15 (compound 14r) is a potent *NF-κB* inhibitor. NF-κB-IN-15 decreases the NO levels and inhibits the release of IL-6, TNF-α, and IL-1β in LPS (HY-D1056) -induced cells. NF-κB-IN-15 inhibits LPS-induced phosphorylation of p65 and degradation of IκBα. NF-κB-IN-15 shows anti-inflammatory activity has the potential for the research of acute lung injury (ALI) .

HY-13982

JSH-23 105+ Cited Publications	NF-κB	Metabolic Disease Inflammation/Immunology Cancer
JSH-23 is an *NF-κB* inhibitor which inhibits NF-κB transcriptional activity with an IC₅₀ of 7.1 μM in lipopolysaccharide (LPS)-stimulated macrophages RAW 264.7. JSH-23 inhibits nuclear translocation of NF-κB p65 without affecting IκBα degradation .

HY-138284

Avenanthramide-C methyl ester	NF-κB	Inflammation/Immunology
Avenanthramide-C methyl ester is an anti-inflammatory agent and NF-κB inhibitor that inhibits the secretion of pro-inflammatory factors. Avenanthramide-C methyl ester inhibits NF-κB activation by inhibiting IKK and IκB phosphorylation and inhibiting proteasome activity .

HY-149496

Akt/NF-κB/MAPK-IN-1	p38 MAPK ERK JNK Interleukin Related TNF Receptor NO Synthase COX	Others
Akt/NF-κB/MAPK-IN-1 (compound 2m) is a potent and orally active inhibitor against NO (IC₅₀=7.70 μM) with no significant toxicity. Akt/NF-κB/MAPK-IN-1 shows anti-inflammatory activity by inhibiting Akt/NF-κB and MAPK signaling pathways .

HY-173488

NF-κB/HIF-1α-IN-1	NF-κB HIF/HIF Prolyl-Hydroxylase Keap1-Nrf2	Cancer
NF-κB/HIF-1α-IN-1 (compound 9c) is a potent blocker of the *NF-κB* activation pathway and demonstrates selective anti-fibrotic activity. NF-κB/HIF-1α-IN-1 shows no significant cytotoxicity in NCI tumor cell lines. In rat models. NF-κB/HIF-1α-IN-1 has been shown to effectively ameliorate liver fibrosis by inhibiting the expression levels of *NF-κB* and HIF-1α, while simultaneously inducing the activation of Nrf2 .

HY-14645

(-)-DHMEQ 25+ Cited Publications Dehydroxymethylepoxyquinomicin	NF-κB	Inflammation/Immunology Cancer
(-)-DHMEQ (Dehydroxymethylepoxyquinomicin) is a potent, selective and irreversible *NF-κB* inhibitor that covalently binds to a cysteine residue. (-)-DHMEQ inhibits nuclear translocation of *NF-κB* and shows anti-inflammatory and anticancer activity .

HY-158156

NF-κB-IN-16	NF-κB Apoptosis	Cancer
NF-κB-IN-16 (compound 9) is a complex (Pt(IV) complex) of *NF-κB* inhibitor and Cisplatin (HY-17394), which has high efficacy and low toxicity in anti-tumor activity. active. NF-κB-IN-16 can cause DNA damage, induce mitochondrial dysfunction, produce reactive oxygen species, and induce apoptosis through the mitochondrial pathway and endoplasmic reticulum stress. NF-κB-IN-16 potently inhibits the NF-κB/MAPK signaling pathway and disrupts PI3K/AKT signaling. NF-κB-IN-16 also exhibits excellent in vivo antitumor efficiency and low toxicity in A549 or A549/CDDP xenograft models .

HY-N0714A

Berbamine dihydrochloride 10+ Cited Publications	NF-κB Autophagy Apoptosis	Cancer
Berbamine dihydrochloride is an inhibitor of *NF-κB* activity with remarkable anti-myeloma efficacy.

HY-147682

NF-κB-IN-5	NF-κB Apoptosis	Cancer
NF-κB-IN-5 (compound 4d) is an orally active and potent *NF-κB* inhibitor by interacting directly with NF-κB. NF-κB-IN-5 shows antitumor activity against human cancer cell lines (HCT116, U87-MG, HepG2, BGC823, PC9), with IC₅₀ values of 5.35, 2.81, 2.83, 2.02 and 3.90 μM, respectively. NF-κB-IN-5 induces apoptosis in U87-MG tumor cell and cell cycle arrest in G0/G1 phase .

HY-10172

IMD-0354 15+ Cited Publications IKK2 Inhibitor V	IKK	Cancer
IMD-0354 (IKK2 Inhibitor V) is a selective IKKβ inhibitor which inhibits NF-κB activity . IMD0354 inhibits TNF-α induced NF-κB transcription activity with an IC₅₀ of 1.2 uM .

HY-N10458

Asperbisabolane L	NF-κB	Inflammation/Immunology
Asperbisabolane L, a sesquiterpenoid, exerts the anti-inflammatory activity by inhibiting the *NF-κB*-activated pathway. Asperbisabolane L inhibits the translocation of NF-κB from cytoplasm to the nucleus. Asperbisabolane L also inhibits NO production in LPS-activated BV-2 microglia cells .

HY-N1987

Cucurbitacin IIb 2 Publications Verification	Apoptosis	Inflammation/Immunology
Cucurbitacin IIb is an active component isolated from Hemsleya amabilis, induces apoptosis with anti-inflammatory activity. Cucurbitacin IIb inhibits phosphorylation of STAT3, JNK and Erk1/2, enhances the phosphorylation of IκB and NF-κB (p65), blocks nuclear translocation of NF-κB (p65) and decreases mRNA levels of IκBα and TNF-α .

HY-N0629

Maslinic acid 10+ Cited Publications Crategolic acid; 2α-Hydroxyoleanolic acid	NF-κB Bacterial HIV Endogenous Metabolite	Inflammation/Immunology Cancer
Maslinic acid can inhibit the DNA-binding activity of NF-κB p65 and abolish the phosphorylation of IκB-α, which is required for p65 activation.

HY-N2827

Aglain C (-)-Aglain C	Others	Others
Aglain C is isolated from A. ponapensis. Aglain C enhances the NF-kB inhibitory activity .

HY-14592

Tectochrysin Techtochrysin; NSC 80687	STAT NF-κB	Cancer
Tectochrysin (Techtochrysin) is one of the major flavonoids of Alpinia oxyphylla Miquel. Tectochrysin inhibits activity of *NF-κB*.

HY-121632

Quinoclamine 2 Publications Verification	NF-κB	Cancer
Quinoclamine, a naphthoquinone derivative, is a *NF-κB* inhibitor. Quinoclamine exhibits anti-cancer activity .

HY-119970

Helenalin 5 Publications Verification	NF-κB	Inflammation/Immunology Cancer
Helenalin is an anti-inflammatory sesquiterpene lactone. Helenalin selectively inhibits transcription factor *NF-κB* by directly targeting p65. Helenalin has alkylating activity, targets the cysteine sulfhydryl groups in the p65 subunit of NF-κB, thereby inhibits its DNA binding .

HY-107593

PS-1145 dihydrochloride	IKK	Inflammation/Immunology
PS-1145 (dihydrochloride) is a potent IκB kinase-2 inhibitor with an IC₅₀ value of 88 nM. PS-1145 (dihydrochloride) inhibits activity of NF-κB by blocking IκB kinase phosphorylation in tumor-bearing rats .

HY-111172

Inotilone	MMP NF-κB	Cancer
Inotilone is an inhibitor of matrix metalloproteinase MMP-2 and MMP-9, to against metastatic in lung cancer cells. Inotilone enhances the activity of the antioxidant enzymes to support its anti-metastatic activity. Inotilone also inhibits IκBα phosphorylation and NFκB p65 nuclear translocation, involving in FAK, PI3K/AKT, MAPKs and NFκB pathways .

HY-B0167A

Sodium Salicylate 5+ Cited Publications Salicylic acid sodium salt; 2-Hydroxybenzoic acid sodium salt	COX NF-κB Ribosomal S6 Kinase (RSK) Autophagy Apoptosis Endogenous Metabolite	Inflammation/Immunology Cancer
Sodium Salicylate (Salicylic acid sodium salt) inhibits cyclo-oxygenase-2 (COX-2) activity independently of transcription factor (NF-κB) activation . Sodium Salicylate is also a S6K inhibitor.Sodium Salicylate is a *NF-κB* inhibitor that decreases inflammatory gene expression and improves repair in aged muscle .

HY-P10469

NBD-2	NF-κB	Inflammation/Immunology Cancer
NBD-2 is an inhibitor of the NEMO-IKKα/β interaction in the *NF-κB* signaling pathway. NBD-2 specifically inhibits the typical *NF-κB* signaling pathway in vitro and in vivo, reducing the inflammatory response in lipopolysaccharide (LPS) induced acute lung injury (ALI). NBD-2 exhibits significant anti-inflammatory activity. NBD-2 can be used to study diseases related to *NF-κB* signaling pathway, including autoimmune diseases, cancer, etc .

HY-N12767

Salixteroside D	p38 MAPK NF-κB	Inflammation/Immunology
Salixteroside D is a salicin derivative, that exhibits anti-inflammatory activity through inhibition of MAPK and NF-κB signaling pathways .

HY-10172R

IMD-0354 (Standard) IKK2 Inhibitor V (Standard)	Reference Standards IKK	Cancer
IMD-0354 (Standard) is the analytical standard of IMD-0354. This product is intended for research and analytical applications. IMD-0354 (IKK2 Inhibitor V) is a selective IKKβ inhibitor which inhibits NF-κB activity . IMD0354 inhibits TNF-α induced NF-κB transcription activity with an IC50 of 1.2 uM .

HY-P10854

TAT-N15	NF-κB Interleukin Related STAT Akt	Neurological Disease Inflammation/Immunology
TAT-N15 is a p55PIK inhibitor with remarkable anti-inflammatory activity and neuroprotective effects. TAT-N15 can significantly inhibit the activation of IL-6, IL-8, Akt, and *NF-κB* pathways, as well as suppress the protein expression of phosphorylated STAT3 and *NF-κB. By inhibiting the activation of Akt, STAT3, and NF-κB* pathways, TAT-N15 is used in research on acute conjunctivitis, allergic rhinitis, chronic obstructive pulmonary disease (COPD), and stroke .

HY-114519

Helenalin acetate 1 Publications Verification	Histone Demethylase NF-κB	Inflammation/Immunology Cancer
Helenalin acetate, a natural *NF-κB* inhibitor, is a potent C/EBPβ inhibitor. Helenalin acetate has anti-inflammatory and anticancer activities .

HY-N3625

Coronalolic acid Coronalonic acid	NF-κB	Inflammation/Immunology
Coronalolic acid, extract from the apical bud of Gardenia sootepenesis Hutch, inhibits TNF-α-induced *NF-κB* activity and NO production .

HY-N2362R

DL-Alanine (Standard)	Endogenous Metabolite	Metabolic Disease
Cucurbitacin IIb (Standard) is the analytical standard of Cucurbitacin IIb. This product is intended for research and analytical applications. Cucurbitacin IIb is an active component isolated from Hemsleya amabilis, induces apoptosis with anti-inflammatory activity. Cucurbitacin IIb inhibits phosphorylation of STAT3, JNK and Erk1/2, enhances the phosphorylation of IκB and NF-κB (p65), blocks nuclear translocation of NF-κB (p65) and decreases mRNA levels of IκBα and TNF-α .

HY-N1987R

Cucurbitacin IIb (Standard)	Apoptosis	Inflammation/Immunology
Cucurbitacin IIb (Standard) is the analytical standard of Cucurbitacin IIb. This product is intended for research and analytical applications. Cucurbitacin IIb is an active component isolated from Hemsleya amabilis, induces apoptosis with anti-inflammatory activity. Cucurbitacin IIb inhibits phosphorylation of STAT3, JNK and Erk1/2, enhances the phosphorylation of IκB and NF-κB (p65), blocks nuclear translocation of NF-κB (p65) and decreases mRNA levels of IκBα and TNF-α .

HY-114981

SRTCX1002	Sirtuin	Inflammation/Immunology
SRTCX1002 is a potent activator of SIRT1 (STAC), suppresses inflammatory responses through promotion of p65 deacetylation and inhibition of NF-κB Activity. SRTCX1002 suppresses stimuli-induced NF-κB transcriptional activation and LPS-induced TNFα secretion with IC₅₀s of 0.71 and 7.58 µM, respectively .

HY-N12527

Hyperelamine A	NF-κB	Others
Hyperelamine A (compound 5) is a polycyclic polyprenylated acylphloroglucinols (PPAPs). Hyperelamine A exhibits inhibitory activity against LPS-activated NO production in BV-2 cells via TLR-4/NF κB signaling .

HY-N3497

Isochamaejasmin	NF-κB DNA/RNA Synthesis Parasite Apoptosis	Infection Cancer
Isochamaejasmin is a biflavonoid with anti-cancer, antiplasmodial and insecticidal activities. Isochamaejasmin displays a potent *NF-κB* (NF-κB) activation activity. Isochamaejasmin could cause DNA damage and induce apoptosis via the mitochondrial pathway in AW1 cells . Isochamaejasmin also has a moderate antiplasmodial activity (IC₅₀ of 7.3 μM for *P. falciparum*) and relatively low cytotoxicity (CC₅₀ of 29.0 μM) .

HY-N1380

Guaiacol 2-Methoxyphenol	COX NF-κB Endogenous Metabolite	Inflammation/Immunology
Guaiacol, a phenolic compound, inhibits LPS-stimulated COX-2 expression and *NF-κB* activation . Anti-inflammatory activity .

HY-W273493

4-Nitrochalcone 2-(4-Nitrobenzylidene)acetophenone	Proteasome	Inflammation/Immunology
4-Nitrochalcone (2-(4-Nitrobenzylidene)acetophenone) inhibits the proteasome, inhibits NF-κB activity induced by TNFα .

HY-125911

Gossypin	NF-κB Aurora Kinase Ribosomal S6 Kinase (RSK) Apoptosis Caspase Bcl-2 Family PARP Cryptochrome	Cardiovascular Disease Inflammation/Immunology Cancer
Gossypin is an orally active flavone isolated from Hibiscus vitifolius. Gossypin has antioxidant, antiinflammatory, anticancer, anticataract, antidiabetic, and hepatoprotective activities. Gossypin inhibits *NF-κB* and NF-κB-regulated gene expression. Gossypin inhibits AURKA and RSK2. Gossypin inhibits invasion and induces apoptosis. Gossypin can be used for gastric cancer study .

HY-116145

MHY884	Tyrosinase NF-κB	Inflammation/Immunology
MHY884 is a tyrosinase inhibitor that suppresses UVB-induced activation of NF-κB signaling pathway through the downregulation of oxidative stress. MHY884 suppresses oxidative stress in the melanoma cells and attenuates UVB-induced oxidative stress, resulting in reduced NF-κB activity in irradiated mice. MHY884 is promising for research of UVB-induced skin damage .

HY-118668

ABD-350	NF-κB	Others
ABD-350 is an antiresorptive agent that inhibits osteoclast activity without affecting osteoblast activity and preventing ovariectomy-induced bone loss. ABD-350 inhibits NF-κB ligand-induced inhibitor of NF-κB phosphorylation, leading to osteoclast apoptosis, but has no inhibitory effect on osteoblast function, effectively preventing bone loss in ovariectomized mice, and does not inhibit parathyroid hormone-induced bone formation.

HY-136718

CLEFMA	Apoptosis	Cancer
CLEFMA is a curcuminoid with antitumor activity. CLEFMA inhibits tumor growth is associated with NF-κB-regulated anti-inflammatory and anti-metastatic effects .

HY-N10768

1-Dehydro-[10]-gingerdione	IKK NF-κB	Inflammation/Immunology
1-Dehydro-[10]-gingerdione directly inhibits IKKβ activity by targeting the activation loop of IKKβ, thus disrupting IKKβ-catalysed IκBα phosphorylation in macrophages stimulated with agonists. 1-Dehydro-[10]-gingerdione inhibits LPS (HY-D1056)-induced *NF-κB* transcriptional activity. 1-Dehydro-[10]-gingerdione has the potential for NF-κB-associated inflammation and autoimmune disorders research .

Cat. No.	Product Name

HY-L199

Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

3,958 compounds

Non-alcoholic fatty liver disease (NAFLD) is one of the most common liver diseases worldwide and is the primary liver manifestation of metabolic syndrome. The growth of NAFLD has coincided with the obesity epidemic. NAFLD is composed of excess lipid accumulation in the liver, causing steatotoxicity, and shows a wide range of histopathological abnormalities. NAFLD may progress from simple steatosis to Non-alcoholic steatohepatitis (NASH) with or without fibrosis (NASH), and eventually to cirrhosis and hepatocellular carcinoma. To date, very few drugs have been approved for marketing specifically for the treatment of NAFLD, so increased efforts to develop NAFLD drugs are necessary.

MCE designs a unique collection of 3,958 small molecules with definite or potential anti-NAFLD activity, which is an important tool for studying the pathological mechanism of NAFLD and developing drugs for NAFLD.

HY-L201

Cell Proliferation Compound Library

2,677 compounds

Cell proliferation, the increase in cell numbers resulting from cell division, is a complex and tightly regulated process. Cell proliferation is regulated by coordinated entry into the cell cycle, and changes in proliferation are closely linked to disease development. Evolutionary dynamics links tumor growth and progression with cell proliferation, cell death, and mutation rates. In addition, cell proliferation is central to degenerative diseases, the development of which is often accompanied by accelerated multiplication of cancer cells. Therefore, assays of cell proliferation levels are frequently used for laboratory research purposes and increasingly for clinical assessment of tumor aggressiveness and potentially to guide care. It has been shown that multiple key targets are collectively involved in regulating the process of cell proliferation, such as CDK, E2F, pRB, β-Catenin, and others.

MCE collects 2,677 compounds that target and regulate key targets of cell proliferation, which can be used in studies of cell proliferation mechanisms and drug discovery.

HY-L124

Anti-Prostate Cancer Compound Library

2,843 compounds

Cancer is one of the leading causes of mortality amongst world’s population, in which prostate cancer (PCa) is one of the most encountered malignancies among men. Several molecular mechanisms are involved in prostate cancer development and progression. These include common survival factors in prostate cancer (IGF-1), growth factors (TGF-α, EGF), Wnt, Hedgehog, NF-κB, and mTOR and other signaling pathways. These provide potential therapeutic target in prostate cancer treatment.

MCE offers a unique collection of 2,843 compounds with identified and potential anti-prostate cancer activity. MCE Anti-Prostate Cancer Compound Library is a useful tool for anti-prostate cancer drugs screening and other related research.

HY-L103

Anti-Colorectal Cancer Compound Library

2,024 compounds

Colorectal cancer (CRC), also known as bowel cancer, colon cancer, or rectal cancer, arises as adenocarcinoma from glandular epithelial cells of the large intestine comprised of the colon and rectum. The majority of cases of CRC are sporadic and result from risk factors, such as a sedentary lifestyle, obesity, processed diets, alcohol consumption and smoking. CRC is also a common preventable cancer.

Studies showed several cellular signaling pathways dysregulated in CRC, leading to the onset of malignant phenotypes. Therefore, it is necessary to analyze the signaling pathways involved in the occurrence and development of colorectal cancer to study the progression and drug treatment of colorectal cancer. Among them, Wnt/β-catenin, p53, TGF-β/SMAD, NF-κB, Notch, VEGF and other target genes and signaling pathways are the focus of research. MCE offers a unique collection of 2,024 compounds with identified and potential anti-colorectal cancer activity. MCE anti-colorectal cancer compound library is a useful tool for anti-colorectal cancer drugs screening and other related research.

HY-L074

Anti-Breast Cancer Compound Library

2,559 compounds

Breast cancer is the most frequent cancer among women, impacting 2.1 million women each year, and also causes the greatest number of cancer-related deaths among women. Surgery is usually the first type of treatment for breast cancer, which is usually followed by chemotherapy or radiotherapy or, in some cases, hormone or targeted therapies, especially for metastatic breast cancer (MBC).

Breast cancer is a heterogeneous disease, which is categorized into 3 major subtypes based on the presence or absence of molecular markers for estrogen or progesterone receptors and human epidermal growth factor 2 (ERBB2; formerly HER2): hormone receptor positive/ERBB2 negative (70% of patients), ERBB2 positive (15%-20%), and triple-negative (tumors lacking all 3 standard molecular markers; 15%). Different intrinsic subtypes exhibit different tumor behavior with different prognoses, and may require specific targeted therapies to maximize treatment effectiveness. Otherwise, some signaling pathways also play important roles in the development of breast cancer, such as NF-κB Signaling Pathway, TGF-beta Signaling Pathway, PI3K/AKT/mTOR signaling pathway and Notch Signaling Pathway. These signaling pathways offer ideal targets for development of new targeted therapies for breast cancer.

MCE supplies a unique collection of 2,559 compounds with identified and potential anti-breast cancer activity. MCE Anti-Breast Cancer Compound Library is a useful tool for anti-breast cancer drugs screening.

Cat. No.	Product Name	Type

HY-W016412

Coenzyme Q0

2 Publications Verification

CoQ0

Enzyme Substrates

Coenzyme Q0 (CoQ0) is a potent, oral active ubiquinone compound can be derived from Antrodia cinnamomea. Coenzyme Q0 induces apoptosis and autophagy, suppresses of HER-2/AKT/mTOR signaling to potentiate the apoptosis and autophagy mechanisms. Coenzyme Q0 regulates NFκB/AP-1 activation and enhances Nrf2 stabilization in attenuation of inflammation and redox imbalance. Coenzyme Q0 has anti-angiogenic activity through downregulation of MMP-9/NF-κB and upregulation of HO-1 signaling .

HY-P1956

Human serum albumin

2 Publications Verification

HSA

Native Proteins

Human serum albumin (HSA) is the most abundant protein in plasma and is a major determinant of plasma oncotic pressure. Human serum albumin exhibits antioxidant, anticoagulant, anti-inflammatory, anti-platelet aggregation activities as well as colloid osmotic action. Human serum albumin can block the inhibitory effect of GML on human T cells, providing protective function for T cells. Human serum albumin is also associated with cardiovascular diseases and can partially prevent the LPS (HY-D1056) induced oxidative stress, as well as the upregulation of NF-κB, NF-κB, and peroxynitrite (ONOO ⁻) in the vascular wall, contributing to the reduction of blood pressure .

HY-W042416

N,N-Dimethylacetamide 1 Publications Verification DMAc	Co-solvents
N,N-Dimethylacetamide (DMAc) is an organic solvent with blood-brain transmissibility and an FDA-approved drug excipient. N, N-dimethylacetamide exerts anti-inflammatory activity by inhibiting the *NF-κB* signaling pathway. N, N-dimethylacetamide can be used in studies of weight gain caused by a high-fat diet and neuroinflammation in Alzheimer's disease .

HY-W009274

N-Acetylmuramic acid

MurNAc; NAMA

Enzyme Substrates

N-acetylmuramic acid is a component of the bacterial cell wall peptidoglycan, essential for maintaining cell shape and integrity . N-acetylmuramic acid inhibits spore germination by inhibiting a coat-associated hexosaminidase and a core enzyme . N-acetylmuramic acid is required by Bacteroides forsythus for proliferation and the maintenance of its cell shape . N-Acetylmuramic acid inhibits the p38 MAPK/NF-κB signaling pathway, and exhibits anti-inflammatory activity. N-Acetylmuramic acid is orally active .

HY-W001925

7-Methoxy-1-tetralone

Biochemical Assay Reagents

7-Methoxy-1-tetralone is a potent antitumor agent. 7-Methoxy-1-tetralone inhibits cancer cell proliferation and migration, and induces hepatocellular carcinoma cell (HCC) apoptosis. 7-Methoxy-1-tetralone decreased the protein levels of NF-κB, matrix metallopeptidase 2 (MMP2)/MMP9, and p-AKT. 7-Methoxy-1-tetralone showed antitumor activity in nude mice and had no effect on body weight and liver, spleen and organ index .

HY-P1956A

Human serum albumin (Cell culture grade, Endotoxin<0.125 EU/mg)

HSA (Cell culture grade, Endotoxin<0.125 EU/mg)

Native Proteins

Human serum albumin (Cell culture grade, Endotoxin<0.125 EU/mg) (HSA) is the most abundant protein in plasma and is a major determinant of plasma oncotic pressure. Human serum albumin (Cell culture grade, Endotoxin<0.125 EU/mg) exhibits antioxidant, anticoagulant, anti-inflammatory, anti-platelet aggregation activities as well as colloid osmotic action. Human serum albumin (Cell culture grade, Endotoxin<0.125 EU/mg) can block the inhibitory effect of GML on human T cells, providing protective function for T cells. Human serum albumin (Cell culture grade, Endotoxin<0.125 EU/mg) is also associated with cardiovascular diseases and can partially prevent the LPS (HY-D1056) induced oxidative stress, as well as the upregulation of NF-κB, iNOS, and peroxynitrite (ONOO ⁻) in the vascular wall, contributing to the reduction of blood pressure .

HY-W042416R

N,N-Dimethylacetamide (Standard)

DMAc (Standard)

Co-solvents

N,N-Dimethylacetamide (Standard) is the analytical standard of N,N-Dimethylacetamide. This product is intended for research and analytical applications. N,N-Dimethylacetamide (DMAc) is an organic solvent with blood-brain transmissibility and an FDA-approved drug excipient. N, N-dimethylacetamide exerts anti-inflammatory activity by inhibiting the NF-κB signaling pathway. N, N-dimethylacetamide can be used in studies of weight gain caused by a high-fat diet and neuroinflammation in Alzheimer's disease .

HY-101410A

SDMA (p-hydroxyazobenzene-p′-sulfonate)

Symmetric dimethylarginine (p-hydroxyazobenzene-p′-sulfonate); NG,NG'-Dimethyl-L-arginine (p-hydroxyazobenzene-p′-sulfonate)

Biochemical Assay Reagents

SDMA p-hydroxyazobenzene-p′-sulfonate is the p-hydroxyazobenzene-p′-sulfonate salt form of SDMA (HY-101410). SDMA p-hydroxyazobenzene-p′-sulfonate is an endogenous inhibitor of nitric oxide synthase (NO synthase) activity. SDMA p-hydroxyazobenzene-p′-sulfonate is an activator for NF-κB, and promotes the expression of IL-6 and TNF-α. SDMA p-hydroxyazobenzene-p′-sulfonate is stable in serum and plasma, and can be used as a kidney biomarker of hepatic and renal dysfunction .

Cat. No.	Product Name	Target	Research Area

HY-P1409A

ADWX 1 TFA	Potassium Channel	Inflammation/Immunology
ADWX 1 TFA is a new peptide inhibitor that is potent and selective for Kv1.3 with an IC₅₀ value of 1.89 pM. ADWX 1 inhibits Kv1.3 channel activity specifically to inhibit both the initial calcium signaling and NF-κB activation. ADWX 1 TFA ameliorates the disease in rats of experimental autoimmune encephalomyelitis (EAE) models. ADWX 1 TFA can be used to study T cell-mediated autoimmune diseases .

HY-P1633

Protegrin-1 PG1	Bacterial ERK COX NF-κB Apoptosis NO Synthase Dengue Virus	Infection Inflammation/Immunology
Protegrin-1 is an orally active antibacterial peptide. Protegrin-1 activates ERK, COX2, NFκB, inhibits Apoptosis, and NO production. Protegrin-1 has antibacterial activity against S. aureus, E. faecium, E. coli, P. aeruginosa and K. Pneumoniae, with MBC values between 10 and 20 µM. Protegrin-1 has antiviral activity against dengue NS2B-NS3. Protegrin-1 has anti-inflammatory activity. Protegrin-1 is used in the study of inflammatory diseases and infections .

HY-P10469

NBD-2	NF-κB	Inflammation/Immunology Cancer
NBD-2 is an inhibitor of the NEMO-IKKα/β interaction in the *NF-κB* signaling pathway. NBD-2 specifically inhibits the typical *NF-κB* signaling pathway in vitro and in vivo, reducing the inflammatory response in lipopolysaccharide (LPS) induced acute lung injury (ALI). NBD-2 exhibits significant anti-inflammatory activity. NBD-2 can be used to study diseases related to *NF-κB* signaling pathway, including autoimmune diseases, cancer, etc .

HY-P10854

TAT-N15	NF-κB Interleukin Related STAT Akt	Neurological Disease Inflammation/Immunology
TAT-N15 is a p55PIK inhibitor with remarkable anti-inflammatory activity and neuroprotective effects. TAT-N15 can significantly inhibit the activation of IL-6, IL-8, Akt, and *NF-κB* pathways, as well as suppress the protein expression of phosphorylated STAT3 and *NF-κB. By inhibiting the activation of Akt, STAT3, and NF-κB* pathways, TAT-N15 is used in research on acute conjunctivitis, allergic rhinitis, chronic obstructive pulmonary disease (COPD), and stroke .

HY-P10850

PIYLGGVFQ	TNF Receptor NF-κB Apoptosis	Inflammation/Immunology
PIYLGGVFQ is a peptide inhibitor for TNF-α. PIYLGGVFQ inhibits TNF-α-mediated apoptosis, NF-κB nuclear translocation and activation. PIYLGGVFQ exhibits anti-arthritic activity in the CIA mouse model .

HY-138096

Z-LLF-CHO Z-Leu-Leu-Phe-CHO	Proteasome	Cancer
Z-LLF-CHO (Z-Leu-Leu-Phe-CHO) is a potent inhibitor of the chymotrypsin-like activity of the pituitary multicatalytic proteinase complex (K_i = 460 nM). Z-LLF-CHO is also a NF-κB nuclear translocation inhibitor .

HY-P10839

NBD peptide	NF-κB	Inflammation/Immunology
NBD peptide inhibits *NF-κB* signaling pathway through inhibition of the NEMO-IKK complex combination. NBD peptide exhibits anti-inflammatory efficacy through block of pro-inflammatory cytokines production. NBD peptide exhibits immunosuppressive activity through regulation of immune cells. NBD peptide enhances its transmembrane ability by combining with cell-penetrating peptide HIV-TAT .

HY-P10349

Pap12-6	Bacterial	Infection Inflammation/Immunology
Pap12-6 is a 12-mer peptide derived from the antimicrobial peptide Papiliocin of yellow butterfly larva. Pap12-6 kills bacteria by penetrating and disrupting their membranes, exhibiting strong antibacterial activity. Pap12-6 exerts its anti-inflammatory effects through the TLR4-mediated *NF-κB* signaling pathway .

HY-P1409

ADWX 1	Potassium Channel	Inflammation/Immunology
ADWX 1 is a new peptide inhibitor that is potent and selective for Kv1.3 with an IC₅₀ value of 1.89 pM. ADWX 1 inhibits Kv1.3 channel activity specifically to inhibit both the initial calcium signaling and NF-κB activation. ADWX 1 ameliorates the disease in rats of experimental autoimmune encephalomyelitis (EAE) models. ADWX 1 can be used to study T cell-mediated autoimmune diseases .

HY-P1684

Peptide P60 FOXP3 inhibitor P60	NF-κB Nuclear Factor of activated T Cells (NFAT)	Infection Inflammation/Immunology Cancer
Peptide P60 is a FOXP3 inhibitor. Peptide P60 can enter cells, inhibit the nuclear translocation of FOXP3, and diminish its ability to suppress the transcription factors *NF-κB* and NFAT. Peptide P60 can inhibit the immunosuppressive activity of regulatory T cells (Treg) derived from mice and humans, and enhance the stimulation of effector T cells in vitro. Peptide P60 can induce a lymphoproliferative autoimmune syndrome with pathological manifestations resembling those reported in scurfy mice lacking functional Foxp3. Peptide P60 can enhance the immunogenicity of cancer and viral vaccines.

HY-P2114

IT9302	Peptides	Cancer
IT9302 is a synthetic IL-10 agonist with the activity of inducing tolerogenic dendritic cells. IT9302 is able to mimic multiple effects of IL-10, including downregulating the antigen presentation machinery and increasing the sensitivity of tumor cells to natural killer cell-mediated lysis. IT9302 can also hinder the response of human monocytes to differentiation factors and reduce the antigen presentation and co-stimulatory capacity of dendritic cells. Dendritic cells treated with IT9302 showed a weakened ability to stimulate T cell proliferation and interferon-γ production. IT9302 exerts its effects through mechanisms that are partially different from IL-10, involving STAT3 inactivation and regulation of the NF-κB intracellular pathway. IT9302-treated dendritic cells showed enhanced expression of membrane-bound TGF-β, associated with the effective induction of foxp3+ regulatory T cells .

Cat. No.	Product Name	Target	Research Area

HY-P9930

Evolocumab 2 Publications Verification AMG 145	NF-κB Ser/Thr Protease Toll-like Receptor (TLR)	Cardiovascular Disease Metabolic Disease Inflammation/Immunology Cancer
Evolocumab (AMG 145) is a human monoclonal antibody that inhibits PCSK9. Evolocumab is used in the study of hypercholesterolemia and atherosclerotic cardiovascular disease. Evolocumab binds to circulating PCSK9 protein and inhibits its binding to LDLR. Evolocumab has antioxidant and cytoprotective activities against H₂O₂-induced oxidative damage to endothelial cells. Evolocumab may also negatively regulate activation of the TLR-4/NF-κB signaling pathway to prevent inflammation .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0714A

Berbamine dihydrochloride 10+ Cited Publications	Alkaloids Structural Classification Monophenols other families Classification of Application Fields Source classification Phenols Plants Isoquinoline Alkaloids Disease Research Fields Cancer	NF-κB Autophagy Apoptosis
Berbamine dihydrochloride is an inhibitor of *NF-κB* activity with remarkable anti-myeloma efficacy.

HY-N1987

Cucurbitacin IIb 2 Publications Verification	Triterpenes Structural Classification Classification of Application Fields Terpenoids Cucurbitaceae Plants Hemsleya amabilis Diels Inflammation/Immunology Disease Research Fields	Apoptosis
Cucurbitacin IIb is an active component isolated from Hemsleya amabilis, induces apoptosis with anti-inflammatory activity. Cucurbitacin IIb inhibits phosphorylation of STAT3, JNK and Erk1/2, enhances the phosphorylation of IκB and NF-κB (p65), blocks nuclear translocation of NF-κB (p65) and decreases mRNA levels of IκBα and TNF-α .

HY-N0629

Maslinic acid 10+ Cited Publications Crategolic acid; 2α-Hydroxyoleanolic acid	Triterpenes Structural Classification other families Classification of Application Fields Terpenoids Source classification Plants Disease Research Fields Cancer	NF-κB Bacterial HIV Endogenous Metabolite
Maslinic acid can inhibit the DNA-binding activity of NF-κB p65 and abolish the phosphorylation of IκB-α, which is required for p65 activation.

HY-14592

Tectochrysin Techtochrysin; NSC 80687	Structural Classification Monophenols Flavonoids Classification of Application Fields Flavones Source classification Phenols Plants Alpinia oxyphylla Miq. Disease Research Fields Zingiberaceae Cancer	STAT NF-κB
Tectochrysin (Techtochrysin) is one of the major flavonoids of Alpinia oxyphylla Miquel. Tectochrysin inhibits activity of *NF-κB*.

HY-119970

Helenalin 5 Publications Verification	Structural Classification other families Classification of Application Fields Terpenoids Sesquiterpenes Source classification Plants Inflammation/Immunology Disease Research Fields	NF-κB
Helenalin is an anti-inflammatory sesquiterpene lactone. Helenalin selectively inhibits transcription factor *NF-κB* by directly targeting p65. Helenalin has alkylating activity, targets the cysteine sulfhydryl groups in the p65 subunit of NF-κB, thereby inhibits its DNA binding .

HY-B0167A

Sodium Salicylate 5+ Cited Publications Salicylic acid sodium salt; 2-Hydroxybenzoic acid sodium salt	Classification of Application Fields Ketones, Aldehydes, Acids Source classification Asclepiadaceae Phenols Plants Periploca sepium Bunge Inflammation/Immunology Disease Research Fields Cancer	COX NF-κB Ribosomal S6 Kinase (RSK) Autophagy Apoptosis Endogenous Metabolite
Sodium Salicylate (Salicylic acid sodium salt) inhibits cyclo-oxygenase-2 (COX-2) activity independently of transcription factor (NF-κB) activation . Sodium Salicylate is also a S6K inhibitor.Sodium Salicylate is a *NF-κB* inhibitor that decreases inflammatory gene expression and improves repair in aged muscle .

HY-114519

Helenalin acetate 1 Publications Verification	Sesquiterpenes Source classification Derris robusta Plants Compositae	Histone Demethylase NF-κB
Helenalin acetate, a natural *NF-κB* inhibitor, is a potent C/EBPβ inhibitor. Helenalin acetate has anti-inflammatory and anticancer activities .

HY-N10458

Asperbisabolane L	Sesquiterpenes	NF-κB
Asperbisabolane L, a sesquiterpenoid, exerts the anti-inflammatory activity by inhibiting the *NF-κB*-activated pathway. Asperbisabolane L inhibits the translocation of NF-κB from cytoplasm to the nucleus. Asperbisabolane L also inhibits NO production in LPS-activated BV-2 microglia cells .

HY-N2827

Aglain C (-)-Aglain C	Structural Classification Natural Products Source classification Aglaia argentea Blume Plants Meliaceae	Others
Aglain C is isolated from A. ponapensis. Aglain C enhances the NF-kB inhibitory activity .

HY-N12767

Salixteroside D	Salix tetrasperma Roxb. Structural Classification Natural Products Source classification Plants Salicaceae	p38 MAPK NF-κB
Salixteroside D is a salicin derivative, that exhibits anti-inflammatory activity through inhibition of MAPK and NF-κB signaling pathways .

HY-N3625

Coronalolic acid Coronalonic acid	Other Terpenoids Structural Classification Classification of Application Fields Terpenoids Source classification Rubiaceae Plants Gardenia jasminoides Ellis Inflammation/Immunology Disease Research Fields	NF-κB
Coronalolic acid, extract from the apical bud of Gardenia sootepenesis Hutch, inhibits TNF-α-induced *NF-κB* activity and NO production .

HY-N2362R

DL-Alanine (Standard)	Structural Classification Human Gut Microbiota Metabolites Source classification Amino acids Endogenous metabolite	Endogenous Metabolite
Cucurbitacin IIb (Standard) is the analytical standard of Cucurbitacin IIb. This product is intended for research and analytical applications. Cucurbitacin IIb is an active component isolated from Hemsleya amabilis, induces apoptosis with anti-inflammatory activity. Cucurbitacin IIb inhibits phosphorylation of STAT3, JNK and Erk1/2, enhances the phosphorylation of IκB and NF-κB (p65), blocks nuclear translocation of NF-κB (p65) and decreases mRNA levels of IκBα and TNF-α .

HY-N1987R

Cucurbitacin IIb (Standard)	Triterpenes Structural Classification Terpenoids Cucurbitaceae Plants Hemsleya amabilis Diels	Apoptosis
Cucurbitacin IIb (Standard) is the analytical standard of Cucurbitacin IIb. This product is intended for research and analytical applications. Cucurbitacin IIb is an active component isolated from Hemsleya amabilis, induces apoptosis with anti-inflammatory activity. Cucurbitacin IIb inhibits phosphorylation of STAT3, JNK and Erk1/2, enhances the phosphorylation of IκB and NF-κB (p65), blocks nuclear translocation of NF-κB (p65) and decreases mRNA levels of IκBα and TNF-α .

HY-N12527

Hyperelamine A	Structural Classification Hypericum elatoides R. Keller Source classification Phenols Polyphenols Hypericaceae Plants	NF-κB
Hyperelamine A (compound 5) is a polycyclic polyprenylated acylphloroglucinols (PPAPs). Hyperelamine A exhibits inhibitory activity against LPS-activated NO production in BV-2 cells via TLR-4/NF κB signaling .

HY-N3497

Isochamaejasmin	Structural Classification Flavonoids Thymelaeaceae Stellera chamaejasme Linn. Plants Other Flavonoids	NF-κB DNA/RNA Synthesis Parasite Apoptosis
Isochamaejasmin is a biflavonoid with anti-cancer, antiplasmodial and insecticidal activities. Isochamaejasmin displays a potent *NF-κB* (NF-κB) activation activity. Isochamaejasmin could cause DNA damage and induce apoptosis via the mitochondrial pathway in AW1 cells . Isochamaejasmin also has a moderate antiplasmodial activity (IC₅₀ of 7.3 μM for *P. falciparum*) and relatively low cytotoxicity (CC₅₀ of 29.0 μM) .

HY-N1380

Guaiacol 2-Methoxyphenol	Structural Classification Human Gut Microbiota Metabolites Monophenols Microorganisms other families Classification of Application Fields Phenols Plants Endogenous metabolite Inflammation/Immunology Disease Research Fields	COX NF-κB Endogenous Metabolite
Guaiacol, a phenolic compound, inhibits LPS-stimulated COX-2 expression and *NF-κB* activation . Anti-inflammatory activity .

HY-W273493

4-Nitrochalcone 2-(4-Nitrobenzylidene)acetophenone	Structural Classification Natural Products Microorganisms Source classification	Proteasome
4-Nitrochalcone (2-(4-Nitrobenzylidene)acetophenone) inhibits the proteasome, inhibits NF-κB activity induced by TNFα .

HY-125911

Gossypin	Malvaceae Cardiovascular Disease Flavonols Structural Classification Classification of Application Fields Source classification Plants Flavonoids Phenols Polyphenols Abelmoschus manihot (Linn.) Medicus Inflammation/Immunology Disease Research Fields	NF-κB Aurora Kinase Ribosomal S6 Kinase (RSK) Apoptosis Caspase Bcl-2 Family PARP Cryptochrome
Gossypin is an orally active flavone isolated from Hibiscus vitifolius. Gossypin has antioxidant, antiinflammatory, anticancer, anticataract, antidiabetic, and hepatoprotective activities. Gossypin inhibits *NF-κB* and NF-κB-regulated gene expression. Gossypin inhibits AURKA and RSK2. Gossypin inhibits invasion and induces apoptosis. Gossypin can be used for gastric cancer study .

HY-N10768

1-Dehydro-[10]-gingerdione	Structural Classification Monophenols Source classification Phenols Plants Zingiberaceae	IKK NF-κB
1-Dehydro-[10]-gingerdione directly inhibits IKKβ activity by targeting the activation loop of IKKβ, thus disrupting IKKβ-catalysed IκBα phosphorylation in macrophages stimulated with agonists. 1-Dehydro-[10]-gingerdione inhibits LPS (HY-D1056)-induced *NF-κB* transcriptional activity. 1-Dehydro-[10]-gingerdione has the potential for NF-κB-associated inflammation and autoimmune disorders research .

HY-B0167AR

Sodium Salicylate (Standard)	Ketones, Aldehydes, Acids Source classification Asclepiadaceae Phenols Plants Periploca sepium Bunge	COX NF-κB Ribosomal S6 Kinase (RSK) Autophagy Apoptosis Endogenous Metabolite
Sodium Salicylate (Standard) is the analytical standard of Sodium Salicylate. This product is intended for research and analytical applications. Sodium Salicylate (Salicylic acid sodium salt) inhibits cyclo-oxygenase-2 (COX-2) activity independently of transcription factor (NF-κB) activation . Sodium Salicylate is also a S6K inhibitor.Sodium Salicylate is a *NF-κB* inhibitor that decreases inflammatory gene expression and improves repair in aged muscle .

HY-N0629R

Maslinic acid (Standard)	Triterpenes Structural Classification other families Terpenoids Source classification Plants	NF-κB Bacterial HIV Endogenous Metabolite
Maslinic acid (Standard) is the analytical standard of Maslinic acid. This product is intended for research and analytical applications. Maslinic acid can inhibit the DNA-binding activity of NF-κB p65 and abolish the phosphorylation of IκB-α, which is required for p65 activation.

HY-N2526

Nervonic acid 4 Publications Verification Selacholeic acid; cis-15-Tetracosenoic acid	Structural Classification Microorganisms other families Ketones, Aldehydes, Acids Source classification Disease markers Endocrine diseases Plants Endogenous metabolite	Endogenous Metabolite NF-κB
Nervonic acid is a monounsaturated fatty acid with oral activity. Nervonic acid exerts anti-inflammatory activity by inhibiting *NF-κB* signaling. Nervonic acid can be used in the study of neurodegenerative diseases .

HY-B0167

Salicylic acid 5+ Cited Publications 2-Hydroxybenzoic acid	Structural Classification Classification of Application Fields Anti-aging Source classification Plants Endogenous metabolite Agricultural Research Monophenols Microorganisms other families Ketones, Aldehydes, Acids Phenols Phytohormone Inflammation/Immunology Disease Research Fields Cancer	COX Autophagy Mitophagy Apoptosis Endogenous Metabolite
Salicylic acid (2-Hydroxybenzoic acid) inhibits cyclo-oxygenase-2 (COX-2) activity independently of transcription factor (NF-κB) activation .

HY-112225

Narasin sodium	Infection Structural Classification Microorganisms Classification of Application Fields Antibiotics Source classification Disease Research Fields Polyether Antibiotics Cancer	Antibiotic Bacterial Parasite NF-κB Apoptosis
Narasin sodium is a cationic ionophore and coccidiostat agent. Narasin inhibits *NF-κB* signaling and induces tumor cells apoptosis. Narasin sodium has antimicrobial and anticancer activity .

HY-N0622

Morusin 5+ Cited Publications Mulberrochromene	Structural Classification Classification of Application Fields Flavones Anti-aging Source classification Plants Infection Flavonoids other families Phenols Polyphenols Inflammation/Immunology Disease Research Fields	NF-κB STAT Bacterial
Morusin is a prenylated flavonoid isolated from Morus alba Linn. with various biological activities, such as antitumor, antioxidant, and anti-bacteria property. Morusin could inhibit *NF-κB* and STAT3 activity.

HY-N11777

(−)-N-Hydroxyapiosporamide NHAP	Structural Classification Alkaloids Microorganisms Source classification Pyridine Alkaloids	NF-κB
(−)-N-Hydroxyapiosporamide (NHAP), an alkaloid, is an *NF-κB* inhibitor with potent antitumor activity in vitro and in vivo. (−)-N-Hydroxyapiosporamide can be used for the research of colorectal cancer (CRC) .

HY-N2083

Handelin	Structural Classification Classification of Application Fields Terpenoids Sesquiterpenes Genista vuralii A.Duran & Dural Plants Compositae Inflammation/Immunology Disease Research Fields	NF-κB
Handelin is a guaianolide dimer from Chrysanthemum boreale that has potent anti-inflammatory activity by down-regulating *NF-κB* signaling and pro-inflammatory cytokine production .

HY-N9971

Hentriacontane	Structural Classification Natural Products Ficus benghalensis L. Source classification Plants Moraceae	NF-κB Bacterial
Hentriacontane is a long-chain alkane. Hentriacontane exerts anti-inflammatory effects by inhibiting the *NF-κB* pathway. Hentriacontane has anti-inflammatory, antitumor and antibacterial activities .

HY-N4182

Licochalcone E 1 Publications Verification	Chalcones Flavonoids Classification of Application Fields Leguminosae Source classification Plants Inflammation/Immunology Disease Research Fields Glycyrrhiza uralensis Fisch.	Akt p38 MAPK Autophagy
Licochalcone E, a flavonoid compound isolated from Glycyrrhiza uralensis, inhibits NF-κB and AP-1 transcriptional activity through the inhibition of AKT and MAPK activation .

HY-125911R

Gossypin (Standard)	Malvaceae Flavonols Structural Classification Flavonoids Source classification Phenols Polyphenols Abelmoschus manihot (Linn.) Medicus Plants	NF-κB Aurora Kinase Ribosomal S6 Kinase (RSK) Apoptosis Bcl-2 Family Caspase Cryptochrome
Gossypin (Standard) is the analytical standard of Gossypin. This product is intended for research and analytical applications. Gossypin is an orally active flavone isolated from Hibiscus vitifolius. Gossypin has antioxidant, antiinflammatory, anticancer, anticataract, antidiabetic, and hepatoprotective activities. Gossypin inhibits *NF-κB* and NF-κB-regulated gene expression. Gossypin inhibits AURKA and RSK2. Gossypin inhibits invasion and induces apoptosis. Gossypin can be used for gastric cancer study.

HY-N1196

Suberosin	Structural Classification Classification of Application Fields Source classification Coumarins Phenylpropanoids Umbelliferae Plants Pluchea indica (L.) Less. Inflammation/Immunology Disease Research Fields	NF-κB
Suberosin, isolated from Plumbago zeylanica, exhibits anti-inflammatory and anticoagulant activity. Suberosin suppresses PHA-induced PBMC proliferation and arrested cell cycle progression from the G1 transition to the S phase through the modulation of the transcription factors *NF-AT* and *NF-κB* .

HY-142100

Licoagrochalcone C	Structural Classification Glycyrrhiza glabra Linn. Flavonoids Leguminosae Source classification Plants Other Flavonoids	NF-κB
Licoagrochalcone C, a flavonoid, reveals efficacious inhibitory activity on *NF-κB* transcription. Licoagrochalcone C shows significant inhibitory activity on LPS (HY-D1056)-induced NO production .

HY-N1382

Asperuloside 2 Publications Verification	Structural Classification Iridoids Classification of Application Fields Terpenoids Source classification Rubiaceae Plants Inflammation/Immunology Disease Research Fields Hedyotis diffusa Willd.	NO Synthase
Asperuloside is an iridoid isolated from Hedyotis diffusa, with anti-inflammatory activity. Asperuloside inhibits inducible nitric oxide synthase (iNOS), suppresses NF-κB and MAPK signaling pathways .

HY-119731

Antidesmone	Structural Classification Alkaloids Piperidine Alkaloids Antidesma membranaceum Müll.Arg. Phyllanthaceae Source classification Plants	p38 MAPK NF-κB
Antidesmone is a isoquinoline alkaloid that can be isolated from Antidesma membranaceum . Antidesmone can prevent acute lung injury in vivo via inhibiting MAPK and *NF-κb* activities .

HY-N0738

Stachydrine hydrochloride 5 Publications Verification	Alkaloids Structural Classification Erythrophleum fordii Oliv. Pyrrole Alkaloids Classification of Application Fields Labiatae Source classification Plants Disease Research Fields Cancer	NF-κB Endogenous Metabolite
Stachydrine hydrochloride is the major active constituent of Leonurus artemisia, which is a potential therapy for cardiovascular diseases . Stachydrine can inhibit the *NF-κB* signal pathway. Anti-hypertrophic activities .

HY-U00450

4-O-Methyl honokiol	Structural Classification Classification of Application Fields Source classification Lignans Plants Monophenols other families Magnolia officinalis. Rehd. et Wils. Magnoliaceae Phenols Phenylpropanoids Inflammation/Immunology Disease Research Fields Cancer	PPAR NF-κB
4-O-Methyl honokiol is a natural neolignan isolated from Magnolia officinalis, acts as a PPARγ agonist, and inhibtis *NF-κB* activity, used for cancer and inflammation research.

HY-14592R

Tectochrysin (Standard)	Structural Classification Monophenols Flavonoids Flavones Source classification Phenols Plants Alpinia oxyphylla Miq. Zingiberaceae	STAT NF-κB
Tectochrysin (Standard) is the analytical standard of Tectochrysin. This product is intended for research and analytical applications. Tectochrysin (Techtochrysin) is one of the major flavonoids of Alpinia oxyphylla Miquel. Tectochrysin inhibits activity of NF-κB.

HY-N3602A

rel-Cleroindicin F Rengyolone	Structural Classification Natural Products Oleaceae Source classification Forsythia koreana (Rehder) Nakai Plants	TNF Receptor NF-κB NO Synthase
rel-Cleroindicin F (Rengyolone) is a cyclohexyl acetyl compound that can be isolated from the fruit of forsythia and has anti-inflammatory activity. It strongly inhibits the production of nitric oxide (NO) and tumor necrosis factor-alpha (TNF-α). rel-Cleroindicin F does this by downregulating the activity of *NF-κB* and *NF-κB* kinases in RAW 264.7 cells stimulated by LPS (HY-D1056), thus inhibiting the expression of inducible nitric oxide synthase (NO Synthase) and nitric oxide production .

HY-130073

Amorfrutin A	Structural Classification Simple Phenylpropanols Leguminosae Source classification Amorpha fruticosaL. Phenylpropanoids Plants	NF-κB Apoptosis
Amorfrutin A is the inhibition of *NF-κB* activation, that inhibits TNF-α-induced IκBα degradation, p65 nuclear translocation, and DNA-binding activity. Amorfrutin A promotes TNF-α-induced apoptosis in HeLa cell through promotion of caspase-3 and PARP proteolysis .

HY-N11996

Aloenin aglycone	Structural Classification Liliaceae Source classification Phenols Polyphenols Aloe vera (L.) Burm. f. Plants	NO Synthase NF-κB
Aloenin aglycone (compound 13) is an NF-κB inhibitor that can be isolated from aloe exudate. Aloenin aglycone inhibits TNFα-induced NF-κB transcriptional activity (IC₅₀: 18.7 μM). Aloenin aglycone (10 μM) also reduced inducible nitric oxide synthase (iNOS) and intercellular adhesion molecule 1 (ICAM-1) gene expression after treatment of HepG2 cells with 10 ng/mL TNFα .

HY-N0452

Hyperoside 5+ Cited Publications	Flavonols Structural Classification Flavonoids Classification of Application Fields Guttiferae Source classification Phenols Polyphenols Plants Inflammation/Immunology Disease Research Fields Hypericum monogynum L.	Influenza Virus Fungal NF-κB Apoptosis
Hyperoside is a *NF-κB* inhibitor, found from Hypericum monogynum. Hyperoside shows anti-tumor, antifungal, anti-inflammatory, anti-viral, and anti-oxidative activities, and can induce apoptosis .

HY-N8311

Goshonoside F5	Structural Classification Terpenoids Source classification Rosaceae Diterpenoids Plants Rubus chingii Hu	NF-κB
Goshonoside F5 can be isolated from the unripe fruits of Rubus chingii. Goshonoside F5 has anti-inflammatory activity, and inhibits NF-κB and MAPK signaling pathway .

HY-N2065

Withaferin A 5+ Cited Publications	Structural Classification other families Classification of Application Fields Source classification Withania somnifera Solanaceae Plants Inflammation/Immunology Disease Research Fields Steroids	NF-κB Ferroptosis
Withaferin A is a steroidal lactone isolated from Withania somnifera, inhibits *NF-kB* activation and targets vimentin, with potent antiinflammatory and anticancer activities. Withaferin A is an inhibitor of endothelial protein C receptor (EPCR) shedding.

HY-121471

Chrysoeriol 2 Publications Verification	Structural Classification Classification of Application Fields Flavones Metabolic Disease Plants Phyllanthus Flavonoids Phenols Polyphenols Euphorbiaceae Brassicaceae Disease Research Fields Coronopus didymus	Endogenous Metabolite
Chrysoeriol is a kind of natural yellow ash, which can be used for heating plants Coronopus didymus. Chrysoeriol suppresses the JAK2/STAT3, IκB/p65, and NF-κB pathways, and has strong anti-inflammatory activity .

HY-122521

Sootepin D	Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Rubiaceae Gardenia sootepensis hutchins. Plants Gardenia jasminoides Ellis Inflammation/Immunology Disease Research Fields	NF-κB
Sootepin D (compound 6), a triterpene from the apical bud of Gardenia sootepensis, inhibits TNF-α-induced *NF-κB* activity with an IC₅₀ of 8.3μM. Sootepin D has anti-inflammatory activity .

HY-N2117

Isoginkgetin 10+ Cited Publications	Structural Classification Flavonoids Ginkgoaceae Classification of Application Fields Source classification Phenols Polyphenols Plants Biflavones Ginkgo biloba Disease Research Fields Cancer	MMP Akt NF-κB Proteasome Apoptosis Autophagy
Isoginkgetin is a pre-mRNA splicing inhibitor inhibitor. Isoginkgetin also inhibits activities of both Akt, *NF-κB* and MMP-9. Isoginkgetin inhibits the activity of the 20S proteasome, induces apoptosis and activates autophagy .

HY-N8884

Coelonin	Structural Classification Appendicula reflexa Blume Orchidaceae Source classification Phenols Polyphenols Plants	PTEN Akt NF-κB Interleukin Related TNF Receptor
Coelonin is a dihydrophenanthrene with anti-inflammation activity. Coelonin inhibits LPS-induced PTEN phosphorylation. Coelonin inhibits *NF-κB* activation and p27Kip1 degradation by regulating the PI3K/AKT pathway negatively. Coelonin can inhibit IκBα phosphorylation and degradation and increases the expression of IκBα protein .

HY-N0907

Ginsenoside Rg6	Panax ginseng C. A. Meyer Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Plants Inflammation/Immunology Disease Research Fields Araliaceae	NF-κB Apoptosis
Ginsenoside Rg6 inhibits TNF-α-induced *NF-κB* transcriptional activity with an IC₅₀ of 29.34 μM in HepG2 cells. Ginsenoside Rg6 also exhibits apoptosis-inducing effect.

HY-N0773

Isovitexin 3 Publications Verification Saponaretin; Homovitexin	Structural Classification Cannabis sativa L Classification of Application Fields Flavones Passifloraceae Plants Moraceae Passiflora coerulea Linn. Flavonoids Palmae Inflammation/Immunology Disease Research Fields Trachycarpus fortunei (Hook.) H. Wendl.	JNK NF-κB
Isovitexin is a flavonoid isolated from passion flower, Cannabis and, and the palm, possesses anti-inflammatory and anti-oxidant activities; Isovitexin acts like a JNK1/2 inhibitor and inhibits the activation of *NF-κB*.

HY-N0819

Raddeanin A 1 Publications Verification	Triterpenes Structural Classification other families Classification of Application Fields Terpenoids Source classification Plants Disease Research Fields Cancer	Apoptosis
Raddeanin A is a natural triterpenoid saponin component of Anemone raddeana, with anti-cancer activities. Raddeanin A exerts anticancer effect on human osteosarcoma via the ROS/JNK and NF-κB signal pathway .

Cat. No.	Product Name	Chemical Structure

HY-N1380S1

Guaiacol-d3
Guaiacol-d₃ is the deuterium labeled Guaiacol. Guaiacol, a phenolic compound, inhibits LPS-stimulated COX-2 expression and NF-κB activation. Guaiacol has an anti-inflammatory activity .

HY-B0167S

Salicylic acid-d6
Salicylic acid-d₆ is a deuterium labeled Salicylic acid (HY-B0167). Salicylic acid inhibits cyclo-oxygenase-2 (COX-2) activity independently of transcription factor (NF-κB) activation .

HY-14655S

Sulfasalazine-d4
Sulfasalazine-d₄ is the deuterium labeled Sulfasalazine. Sulfasalazine (NSC 667219) is an anti-rheumatic agent for the research of rheumatoid arthritis and ulcerative colitis. Sulfasalazine can suppress NF-κB activity. Sulfasalazine is a type 1 ferroptosis inducer .

HY-N0005S

Curcumin-d6
Curcumin-d₆is a deuterium labeled Curcumin (Turmeric yellow). Curcumin (Turmeric yellow) is a natural phenolic compound with diverse pharmacologic effects including anti-inflammatory, antioxidant, antiproliferative and antiangiogenic activities. Curcumin is an inhibitor of p300 histone acetylatransferase (HATs) and also shows inhibitory effects on NF-κB and MAPKs.

HY-N1380S

Guaiacol-d7
Guaiacol-d₇ is the deuterium labeled Guaiacol . Guaiacol, a phenolic compound, inhibits LPS-stimulated COX-2 expression and NF-κB activation . Anti-inflammatory activity .

HY-N1380S3

Guaiacol-d4
Guaiacol-d₄ is the deuterium labeled Guaiacol . Guaiacol, a phenolic compound, inhibits LPS-stimulated COX-2 expression and NF-κB activation . Anti-inflammatory activity .

HY-N1380S4

Guaiacol-d4-1
Guaiacol-d₄-1 is the deuterium labeled Guaiacol . Guaiacol, a phenolic compound, inhibits LPS-stimulated COX-2 expression and NF-κB activation . Anti-inflammatory activity .

HY-N1380S2

Guaiacol-13C6
Guaiacol- ¹³C₆ is the ¹³C labeled Guaiacol . Guaiacol, a phenolic compound, inhibits LPS-stimulated COX-2 expression and NF-κB activation . Anti-inflammatory activity .

HY-12383S

Pelubiprofen-13C,d3

Pelubiprofen- ¹³C,d₃ is the ¹³C- and deuterium labeled Pelubiprofen. Pelubiprofen, an orally active and non-steroidal anti-inflammatory drug, is a member of the 2-arylpropionic acid family and has relatively selective effects on COX-2 activity. Pelubiprofen inhibits COX activity and the transforming growth factor-β activated kinase 1-IκB kinase β-NF-κB pathway, and has significant anti-inflammatory and analgesic effects .

HY-W778225

Vanillic acid-13C6
Vanillic acid- ¹³C6 is the ¹³C labeled isotope of Vanillic acid- ¹³C6(HY-N0708 ).Vanillic acid is a flavoring agent found in edible plants and fruits, and in the root of angelica. Vanillic acid inhibits NF-κB activation. It has anti-inflammatory and antimicrobial activities.

HY-14655S1

Sulfasalazine-d3,15N
Sulfasalazine-d₃, ¹⁵N is ¹⁵N and deuterated labeled Sulfasalazine (HY-14655). Sulfasalazine (NSC 667219) is an anti-rheumatic agent for the research of rheumatoid arthritis and ulcerative colitis. Sulfasalazine can suppress *NF-κB* activity. Sulfasalazine is a type 1 ferroptosis inducer .

HY-N0803S

Myrcene-d6
Myrcene-d6 is the deuterium labeled Myrcene. Myrcene (β-Myrcene) is a type of aromatic compound that inhibits TNFα and NF-κB activity. Myrcene has anti-invasive action, inhibits cell cycle, and leads to cancer cell apoptosis. Myrcene has strong blood protection effect, anti-inflammation, and anti-inflammatory activity .

HY-137315S

TML-6-d3
TML-6-d₃ is the deuterium labeled TML-6. TML-6, an orally active curcumin derivative, inhibits the synthesis of the β-amyloid precursor protein and β-amyloid (Aβ). TML-6 can upregulate Apo E, suppress NF-κB and mTOR, and increase the activity of the anti-

HY-10227S

Bortezomib-d8
Bortezomib-d₈ is the deuterium labeled Bortezomib. Bortezomib (PS-341) is a reversible and selective proteasome inhibitor, and potently inhibits 20S proteasome (Ki=0.6 nM) by targeting a threonine residue. Bortezomib disrupts the cell cycle, induces apoptosis, and inhibits NF-κB. Bortezomib is the first proteasome inhibitor anticancer agent. Anti-cancer activity .

HY-N0803S1

Myrcene-13C3
Myrcene- ¹³C₃ is ¹³C labeled Myrcene (HY-N0803). Myrcene (β-Myrcene) is a type of aromatic compound that inhibits TNFα and NF-κB activity. Myrcene has anti-invasive action, inhibits cell cycle, and leads to cancer cell apoptosis. Myrcene has strong blood protection effect, anti-inflammation, and anti-inflammatory activity .

HY-15027S3

5-Aminosalicylic acid-d3 disodium
5-Aminosalicylic acid-d₃ disodium is deuterated labeled 5-Aminosalicylic Acid (HY-15027). 5-Aminosalicylic acid (Mesalamine) acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and *NF-κB*.5-Aminosalicylic acid can inhibit the activity of osteopontin (OPN).

HY-15027S4

5-Aminosalicylic acid-d7
5-Aminosalicylic acid-d₇ (5-ASA-d₇; Mesalamie-d₇; Mesalazie-d₇) is deuterium labeled 5-Aminosalicylic Acid. 5-Aminosalicylic acid (Mesalamine) acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and *NF-κB. 5-Aminosalicylic acid can inhibit the activity* of osteopontin (OPN) .

HY-N0005S1

Curcumin-d3

Curcumin-d₃ (Diferuloylmethane-d₃ ) is deuterium labeled Curcumin. Curcumin (Diferuloylmethane), a natural phenolic compound, is a p300/CREB-binding protein-specific inhibitor of acetyltransferase, represses the acetylation of histone/nonhistone proteins and histone acetyltransferase-dependent chromatin transcription. Curcumin shows inhibitory effects on NF-κB and MAPKs, and has diverse pharmacologic effects including anti-inflammatory, antioxidant, antiproliferative and antiangiogenic activities. Curcumin induces stabilization of Nrf2 protein through Keap1 cysteine modification.

HY-W015490S

1,4-Naphthoquinone-d6

1,4-Naphthoquinone-d₆ is the deuterium labeled 1,4-Naphthoquinone. 1,4-Naphthoquinone is an inhibitor with broad-spectrum inhibitory activity targeting DNA polymerase, NF-κB and monoamine oxidase (MAO-A/B), with antibacterial and anti-biofilm efficacy. 1,4-Naphthoquinone is a competitive inhibitor of MAO-B (Ki=1.4 μM) and a non-competitive inhibitor of MAO-A (Ki=7.7 μM). 1,4-Naphthoquinone inhibits DNA polymerase pol α, β, γ, δ, ε, λ with IC₅₀ ranging from 5.57-128 μM. 1,4-Naphthoquinone inhibits tumor cell proliferation, induces apoptosis and necrosis, and has anti-angiogenic and anti-inflammatory activities by inducing oxidative stress, depleting glutathione (GSH), inhibiting DNA polymerase-mediated DNA synthesis and blocking NF-κB nuclear translocation. 1,4-Naphthoquinone can be used in anti-bacterial , anti-tumor and anti-inflammatory studies, including inhibition of melanoma and colon cancer cell growth and endothelial cell function, as well as LPS-induced inflammation models .

HY-B0678S

Metaxalone-d3

Metaxalone-d₃ is the deuterium labeled Metaxalone. Metaxalone (AHR438; NSC170959) is an FDA-approved muscle relaxant. Metaxalone acts mainly on the central nervous system and achieves muscle relaxation by inhibiting polysynaptic reflex arcs. In addition, Metaxalone is an inhibitor of MAO-A, which has anti-inflammatory and antioxidant effects. Metaxalone inhibits IL-1β-induced inflammatory phenotype, modulates NF-κB and other related signaling pathways, and decreases MAO-A expression and activity in IL-1β-treated microglia .

HY-B0678S1

Metaxalone-d6

Metaxalone-d₆ is deuterium labeled Metaxalone. Metaxalone (AHR438; NSC170959) is an FDA-approved muscle relaxant. Metaxalone acts mainly on the central nervous system and achieves muscle relaxation by inhibiting polysynaptic reflex arcs. In addition, Metaxalone is an inhibitor of MAO-A, which has anti-inflammatory and antioxidant effects. Metaxalone inhibits IL-1β-induced inflammatory phenotype, modulates NF-κB and other related signaling pathways, and decreases MAO-A expression and activity in IL-1β-treated microglia .

HY-B0809S1

Theophylline-d3

Theophylline-d₃ is deuterated labeled Theophylline (HY-B0809). Theophylline (1,3-Dimethylxanthine) is a potent phosphodiesterase (PDE) inhibitor, adenosine receptor antagonist, and histone deacetylase (HDAC) activator. Theophylline (1,3-Dimethylxanthine) inhibits PDE3 activity to relax airway smooth muscle. Theophylline (1,3-Dimethylxanthine) has anti-inflammatory activity by increase IL-10 and inhibit NF-κB into the nucleus. Theophylline (1,3-Dimethylxanthine) induces apoptosis. Theophylline (1,3-Dimethylxanthine) can be used for asthma and chronic obstructive pulmonary disease (COPD) research .

HY-W050154S

Kojic acid-13C6

Kojic acid- ¹³C₆ is ¹³C labeled Kojic acid (HY-W050154). Kojic acid is a substance produced by Aspergillus oryzae that is orally effective and can also be absorbed transdermally. Kojic acid exhibits various biological activities, including anti-aging, anti-nematode, antimicrobial, antioxidant, and anti-inflammatory effects. Kojic acid is a Tyrosinase inhibitor with an Mushroom Tyrosinase IC50 of 182.7 μM. Kojic acid prevents melanin production by capturing copper ions that bind to the tyrosinase active site, thus inhibiting its activation. Kojic acid also suppresses the NF-κB and p21 signaling pathways in human keratinocytes. Kojic acid derivatives have anticancer activity .

HY-N5060S

Estragole-d4

Estragole-d₄ is deuterated labeled Estragole (HY-N5060). Estragole (4-Allylanisole) is a relatively nontoxic volatile terpenoid ether and major component of the essential oil from many plants. Estragole significantly triggers Apoptosis, suppresses LPS-induced intracellular ROS production. Estragole activats Nrf-2 and regulates NF-κB. Estragole has anti-toxoplasma, anti-inflammatory, anti-edema, antioxidant and immunomodulatory properties. Estragole blocks DRG neuron excitability. Estragole has improves gastric ulcer activity [10] .

HY-B0380S2

Trimebutine-d3 hydrochloride

Trimebutine-d₃ hydrochloride is deuterium labeled Trimebutine hydrochloride. Trimebutine hydrochloride is a multi-target inhibitor and opioid receptor agonist with antimuscarinic activity. Trimebutine hydrochloride inhibits L-type Ca ²⁺ channels and large-conductance calcium-activated potassium channels (BK_Ca channels), thereby inhibiting extracellular calcium influx and potassium ion efflux. Trimebutine hydrochloride also targets Toll-like receptors, inhibits Toll-like receptor 2/4/7/8/9 signals, and inhibits LPS-induced IRAK1 activation, as well as ERK1/2, JNK and NF-κB activation, thereby exerting anti-inflammatory effects. Trimebutine hydrochloride also induces tumor cell apoptosis by inhibiting the AKT/ERK pathway. Trimebutine hydrochloride also inhibits excessive contraction of smooth muscle and can be used in the study of gastrointestinal disorders such as irritable bowel syndrome (IBS) .

HY-B0380S1

Trimebutine-d5 fumarate

Trimebutine-d₅ fumarate is deuterium labeled Trimebutine fumarate. Trimebutine fumarate is a multi-target inhibitor and opioid receptor agonist with antimuscarinic activity. Trimebutine fumarate inhibits L-type Ca ²⁺ channels and large-conductance calcium-activated potassium channels (BK_Ca channels), thereby inhibiting extracellular calcium influx and potassium ion efflux. Trimebutine fumarate also targets Toll-like receptors, inhibits Toll-like receptor 2/4/7/8/9 signals, and inhibits LPS-induced IRAK1 activation, as well as ERK1/2, JNK and NF-κB activation, thereby exerting anti-inflammatory effects. Trimebutine fumarate also induces tumor cell apoptosis by inhibiting the AKT/ERK pathway. Trimebutine fumarate also inhibits excessive contraction of smooth muscle and can be used in the study of gastrointestinal disorders such as irritable bowel syndrome (IBS) .

Cat. No.	Product Name		Classification

HY-168328

FKK6		Alkynes
FKK6 is a selective agonist for pregnane X receptor (PXR) with an EC₅₀ of 1.2 µM. FKK6 exhibits good affinity with plasma proteins, and good metabolic metabolism in human microsomes. FKK6 inhibits PXR-related *NF-κB* signaling pathway, inhibits the expression of inflammatory factors, and exhibits anti-inflammatory activity against DSS (HY-116282)-induced colitis in mouse model .

Cat. No.	Product Name		Classification

HY-N2041

Myristic acid 5 Publications Verification		Emulsifiers
Myristic acid is an orally active saturated 14-carbon fatty acid found in most animal and plant fats, especially milk fat coconut oil, palm oil and nutmeg oil. Myristic acid exerts anti-inflammatory activity through the *NF-κB* pathway. Myristic acid has antibacterial, anti-inflammatory and analgesic properties .

HY-154629

Sesame Oil 1 Publications Verification		Solvents
Sesame Oil is a vegetable oil. Sesame Oil can be extracted from the seeds of Sesamum indicum L. Sesame Oil decreases *NF-κB, aspartate aminotransferase, alanine aminotransferase, IL-1β, IL-4* and nitric oxide. Sesame Oil has antitumor activity against malignant melanoma. Sesame Oil has protective effects against liver damage caused by various agents such as Cisplatin (HY-17394) and Acetaminophen (HY-66005). Sesame Oil shows antinociceptive and anti-inflammatory activities .

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