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Results for "

transmembrane protein

" in MedChemExpress (MCE) Product Catalog:

By Targets:	CFTR (16) Transmembrane Glycoprotein (1) Antibiotic (1) Apoptosis (3) Autophagy (7) Bacterial (6) Biochemical Assay Reagents (2) CaMK (2) CD19 (1) CD47 (1) Chloride Channel (6) CXCR (1) Drug Derivative (1) Endogenous Metabolite (3) Endothelin Receptor (3) G Protein-coupled Receptor Kinase (GRK) (1) GLP Receptor (1) Hedgehog (1) HIV (1) iGluR (1) Interleukin Related (2) Isotope-Labeled Compounds (3) Ligands for Target Protein for PROTAC (1) MHC (2) Mitochondrial Metabolism (5) mRNA (7) Mucin (1) Notch (2) P-glycoprotein (5) PI3K (1) Potassium Channel (6) Reactive Oxygen Species (ROS) (1) Reference Standards (4) RET (17) Reverse Transcriptase (1) SARS-CoV (1) Smo (4) STAT (1) STING (3) TNF Receptor (1)
By Research Areas:	Cancer (40) Cardiovascular Disease (7) Endocrinology (2) Infection (5) Inflammation/Immunology (16) Metabolic Disease (6) Neurological Disease (9)
Oligonucleotides:	mRNA (7) Polymers (1)

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Caraphenol A	Others	Inflammation/Immunology
Caraphenol A is a resveratrol trimer and is able to transiently reduce *interferon-induced transmembrane* (IFITM)** protein expression. Caraphenol A safely enhances lentiviral vector gene delivery to hematopoietic stem and progenitor cells . Caraphenol A also inhibits human cystathionine β-synthase (hCBS) and human cystathionine γ- lyase (hCSE) with IC₅₀s of 5.9 μM and 12.1 μM, respectively .

Saridegib IPI-926; Patidegib	Smo	Cancer
Saridegib is a potent and specific inhibitor of Smoothened (Smo), a key signaling transmembrane protein in the Hedgehog (Hh) pathway.

Navocaftor 1 Publications Verification GLPG 3067; ABBV-3067	CFTR	Others
Navocaftor (GLPG 3067), as a cystic fibrosis transmembrane regulator (CFTR), is a protein modulator (US 20200377491 Al, example 1) .

Posenacaftor sodium 1 Publications Verification PTI-801 sodium	CFTR	Inflammation/Immunology
Posenacaftor (PTI-801) sodium is a cystic fibrosis transmembrane regulator (CFTR) protein modulator that corrects the folding and trafficking of CFTR protein. Posenacaftor sodium is used for the research of cystic fibrosis (CF) .

(R)-Posenacaftor sodium (R)-PTI-801 sodium	CFTR	Inflammation/Immunology
(R)-Posenacaftor (R)-PTI-801) sodium is the R enantiomer of Posenacaftor. Posenacaftor is a cystic fibrosis transmembrane regulator (CFTR) protein modulator that corrects the folding and trafficking of CFTR protein. Posenacaftor is used for the research of cystic fibrosis (CF) .

Ipomoeassin F Ipom-F	SARS-CoV	Infection Cancer
Ipomoeassin F is a potent and selective endoplasmic reticulum (ER) protein-translocation inhibitor by targeting the pore-forming subunit of the Sec61 complex (Sec61α) at the ER membrane. Ipomoeassin F selectively inhibits the ER membrane translocation of SARS-CoV-2 proteins. Ipomoeassin F block the ER translocation of secretory proteins and type I transmembrane proteins (TMPs), but not type III TMPs .

Saridegib hydrochloride IPI 926 hydrochloride; Patidegib hydrochloride	Smo	Cancer
Saridegib hydrochloride is a potent and specific inhibitor of Smoothened (Smo), a key signaling transmembrane protein in the Hedgehog (Hh) pathway.

Zatonacaftor	CFTR	Inflammation/Immunology
Zatonacaftor is a modulator of *cystic fibrosis transmembrane* regulator (CFTR*) protein*. Zatonacaftor can be used for research of cystic fibrosis .

Posenacaftor PTI-801	CFTR	Inflammation/Immunology
Posenacaftor (PTI-801) is a cystic fibrosis transmembrane regulator (CFTR) protein modulator that corrects the folding and trafficking of CFTR protein. Posenacaftor is used for the research of cystic fibrosis (CF) .

Human IL12RB1 mRNA	mRNA	Inflammation/Immunology
Human IL12RB1 mRNA encodes the human interleukin 12 receptor subunit beta 1 (IL12RB1) protein, a type I transmembrane protein that belongs to the hemopoietin receptor superfamily.

Human IL27RA mRNA	mRNA	Inflammation/Immunology
Human IL27RA mRNA encodes the human interleukin 27 receptor subunit alpha (IL27RA) protein, a protein that is similar to the mouse T-cell cytokine receptor (Tccr) at the amino acid level. IL27RA is predicted to be a glycosylated transmembrane protein.

Endothelin-3, human, mouse, rabbit, rat Endothelin 3 (Rat,Human)	G Protein-coupled Receptor Kinase (GRK)	Cardiovascular Disease Neurological Disease
Endothelin-3, human, mouse, rabbit, rat is a 21-amino acid vasoactive peptide that binds to G-protein-linked transmembrane receptors, ET-RA and ET-RB.

MONNA	Chloride Channel	Cardiovascular Disease
MONNA is a potent transmembrane protein 16A (TMEM16A, Anoctamin-1) blocker with an IC₅₀ of 80 nM. MONNA induces vasorelaxation of rodent resistance arteries in presence or absence of chloride ions .

Endothelin-3, human, mouse, rabbit, rat TFA 1 Publications Verification Endothelin 3 (Rat,Human) TFA	Endothelin Receptor	Cardiovascular Disease Neurological Disease
Endothelin-3, human, mouse, rabbit, rat TFA is a 21-amino acid vasoactive peptide that binds to G-protein-linked transmembrane receptors, ET-RA and ET-RB.

Endothelin-2 (49-69), human Endothelin-2 (human, canine); Human endothelin-2	Endothelin Receptor	Cardiovascular Disease Cancer
Endothelin-2 (49-69), human (Endothelin-2 (human, canine)) is a 21-amino acid vasoactive peptide that binds to G-protein-linked transmembrane receptors, ET-RA and ET-RB.

KSPWFTTL	MHC	Inflammation/Immunology Cancer
KSPWFTTL is an immunodominant Kb-restricted epitope from the p15E transmembrane protein. KSPWFTTL can restore susceptibility of a tumor line to anti-AKR/Gross MuLV cytotoxic T lymphocytes .

Human BMPR1B mRNA	mRNA	Cancer
Human BMPR1B mRNA encodes the human bone morphogenetic protein receptor type 1B (BMPR1B) protein, a family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis.

N-Acetylglucosaminyltransferase 1 EC:2.4.1.101; MGAT1	Biochemical Assay Reagents	Others
N-Acetylglucosaminyltransferase1 (EC:2.4.1.101, MGAT1) shows typical features of a type II transmembrane protein. N-Acetylglucosaminyltransferase1 is believed to be essential for normal embryogenesis .

Human BMPR1A mRNA	mRNA	Cancer
Human BMPR1A mRNA encodes the human bone morphogenetic protein receptor type 1A (BMPR1A) protein, a family of transmembrane serine/threonine kinases. BMPR1A may play a role in positively regulating chondrocyte differentiation through GDF5 interaction and mediating induction of adipogenesis by GDF6.

KSPWFTTL TFA	MHC	Inflammation/Immunology Cancer
KSPWFTTL TFA is an immunodominant Kb-restricted epitope from the p15E transmembrane protein. KSPWFTTL TFA can restore susceptibility of a tumor line to anti-AKR/Gross MuLV cytotoxic T lymphocytes .

Endothelin-2 (49-69), human TFA Endothelin-2 (49-69) (human, canine) TFA; Human endothelin-2 TFA	Endothelin Receptor	Cardiovascular Disease Cancer
Endothelin-2 (49-69), human (TFA) (Endothelin-2 (49-69) (human, canine) (TFA)) is a 21-amino acid vasoactive peptide that binds to G-protein-linked transmembrane receptors, ET-RA and ET-RB.

Notch 1	Notch	Cardiovascular Disease Cancer
Notch 1 (Notch homolog 1, translocation-associated) can encode a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple different domain types .

Human IL4R mRNA	mRNA	Inflammation/Immunology
Human IL4R mRNA encodes the human interleukin 4 receptor (IL4R) protein, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. IL4R also can bind interleukin 4 to promote differentiation of Th2 cells.

RET-IN-28	RET	Cancer
RET-IN-28 (Compound 16) is a RET (transmembrane receptor tyrosine protein kinase) inhibitor. RET-IN-28 inhibits the activity of the mutant RET enzyme (RET-V804M), and can be applied to cancer research .

Notch 1 TFA	Notch	Cardiovascular Disease Cancer
Notch 1 TFA (Notch homolog 1, translocation-associated) can encode a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple different domain types .

MUC1, mucin core	Mucin	Cancer
MUC1, mucin core is the region of the MUC1 mucin core. MUC1 is a type I transmembrane glycoprotein, and is overexpressed and aberrantly glycosylated in carcinoma cells. MUC1, mucin core protein binds to domain 1 of ICAM-1 .

Human TGFBR2 mRNA	mRNA	Inflammation/Immunology
Human TGFBR2 mRNA encodes the human transforming growth factor beta receptor 2 (TGFBR2) protein, a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with TGF-beta receptor type-1, and binds TGF-beta. TGFBR2/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of genes related to cell proliferation, cell cycle arrest, wound healing, immunosuppression, and tumorigenesis.

Bamocaftor potassium VX-659 potassium	CFTR	Endocrinology
Bamocaftor potassium is a cystic fibrosis transmembrane conductance regulator (CFTR) corrector designed to restore F508del-CFTR protein function. Bamocaftor potassium can be used combine with Tezacaftor (HY-15448) and Ivacaftor (HY-13017) in cystic fibrosis research .

Trimethyl chitosan N,N,N-Trimethylchitosan	Drug Derivative	Others
Trimethyl chitosan (N,N,N-Trimethylchitosan) is a multifunctional polymer and a derivative of Chitosan (HY-B2144A). Trimethyl chitosan targets the absorption enhancing proteins of tight junctions of intestinal and mucosal epithelial cells, induces tight junction protein rearrangement, and increases intercellular permeability. Trimethyl chitosan can stimulate the activity of promoting transmembrane transport of hydrophilic drugs (such as peptides and proteins) and can be used for drug delivery and synthesis of nanoparticles .

RET S891A Recombinant Human Active Protein Kinase	RET	Cancer
Rearranged during transfection (RET) is a transmembrane receptor protein tyrosine kinase (PTK) activated normally by forming ternary complexes with its cognate ligands and co-receptors. RET alterations by point mutations and gene fusions were found in diverse cancers. RET S891A is a mutant of RET. RET S891A Recombinant Human Active Protein Kinase is a recombinant RET S891A protein that can be used to study RET S891A-related functions .

RET V804L Recombinant Human Active Protein Kinase	RET	Cancer
Rearranged during transfection (RET) is a transmembrane receptor protein tyrosine kinase (PTK) activated normally by forming ternary complexes with its cognate ligands and co-receptors. RET alterations by point mutations and gene fusions were found in diverse cancers. RET V804L is a mutant of RET. RET V804L Recombinant Human Active Protein Kinase is a recombinant RET V804L protein that can be used to study RET V804L-related functions .

Bamocaftor 1 Publications Verification VX-659	CFTR	Endocrinology
Bamocaftor (VX-659) is a cystic fibrosis transmembrane conductance regulator (CFTR) corrector designed to restore F508del-CFTR protein function. Bamocaftor can be used combine with Tezacaftor (HY-15448) and Ivacaftor (HY-13017) in cystic fibrosis research .

T16Ainh-A01 2 Publications Verification	Chloride Channel	Others
T16Ainh-A01, an aminophenylthiazole, is a potent transmembrane protein 16A (TMEM16A) inhibitor, inhibiting TMEM16A-mediated chloride currents with an IC₅₀ value of ~1 µM. TMEM16A (ANO1) functions as a calcium-activated chloride channel (CaCC) .

CKS-17	Reverse Transcriptase	Inflammation/Immunology
CKS-17 is a synthetic retroviral envelope peptide. CKS-17 has the highly conserved amino acid sequences occurring within the transmembrane envelope protein of many animal and human retroviruses. CKS-17 acts as an immunomodulatory epitope and exhibits suppressive properties for numerous immune functions .

RET Y791F Recombinant Human Active Protein Kinase	RET	Cancer
Rearranged during transfection (RET) is a transmembrane receptor protein tyrosine kinase (PTK) activated normally by forming ternary complexes with its cognate ligands and co-receptors. RET alterations by point mutations and gene fusions were found in diverse cancers. RET Y791F is a mutant of RET. RET Y791F Recombinant Human Active Protein Kinase is a recombinant RET Y791F protein that can be used to study RET Y791F-related functions .

RET V804E Recombinant Human Active Protein Kinase	RET	Cancer
Rearranged during transfection (RET) is a transmembrane receptor protein tyrosine kinase (PTK) activated normally by forming ternary complexes with its cognate ligands and co-receptors. RET alterations by point mutations and gene fusions were found in diverse cancers. RET V804E is a mutant of RET. RET V804E Recombinant Human Active Protein Kinase is a recombinant RET V804E protein that can be used to study RET V804E-related functions .

RET L730I Recombinant Human Active Protein Kinase	RET	Cancer
Rearranged during transfection (RET) is a transmembrane receptor protein tyrosine kinase (PTK) activated normally by forming ternary complexes with its cognate ligands and co-receptors. RET alterations by point mutations and gene fusions were found in diverse cancers. RET L730I is a mutant of RET. RET L730I Recombinant Human Active Protein Kinase is a recombinant RET L730I protein that can be used to study RET L730I-related functions .

RET V804M Recombinant Human Active Protein Kinase	RET	Cancer
Rearranged during transfection (RET) is a transmembrane receptor protein tyrosine kinase (PTK) activated normally by forming ternary complexes with its cognate ligands and co-receptors. RET alterations by point mutations and gene fusions were found in diverse cancers. RET V804M is a mutant of RET. RET V804M Recombinant Human Active Protein Kinase is a recombinant RET V804M protein that can be used to study RET V804M-related functions .

RET G691S Recombinant Human Active Protein Kinase	RET	Cancer
Rearranged during transfection (RET) is a transmembrane receptor protein tyrosine kinase (PTK) activated normally by forming ternary complexes with its cognate ligands and co-receptors. RET alterations by point mutations and gene fusions were found in diverse cancers. RET G691S is a mutant of RET. RET G691S Recombinant Human Active Protein Kinase is a recombinant RET G691S protein that can be used to study RET G691S-related functions .

RET G810C Recombinant Human Active Protein Kinase	RET	Cancer
Rearranged during transfection (RET) is a transmembrane receptor protein tyrosine kinase (PTK) activated normally by forming ternary complexes with its cognate ligands and co-receptors. RET alterations by point mutations and gene fusions were found in diverse cancers. RET G810C is a mutant of RET. RET G810C Recombinant Human Active Protein Kinase is a recombinant RET G810C protein that can be used to study RET G810C-related functions .

RET M918T Recombinant Human Active Protein Kinase	RET	Cancer
Rearranged during transfection (RET) is a transmembrane receptor protein tyrosine kinase (PTK) activated normally by forming ternary complexes with its cognate ligands and co-receptors. RET alterations by point mutations and gene fusions were found in diverse cancers. RET M918T is a mutant of RET. RET M918T Recombinant Human Active Protein Kinase is a recombinant RET M918T protein that can be used to study RET M918T-related functions .

RET R813Q Recombinant Human Active Protein Kinase	RET	Cancer
Rearranged during transfection (RET) is a transmembrane receptor protein tyrosine kinase (PTK) activated normally by forming ternary complexes with its cognate ligands and co-receptors. RET alterations by point mutations and gene fusions were found in diverse cancers. RET R813Q is a mutant of RET. RET R813Q Recombinant Human Active Protein Kinase is a recombinant RET R813Q protein that can be used to study RET R813Q-related functions .

RET L730M Recombinant Human Active Protein Kinase	RET	Cancer
Rearranged during transfection (RET) is a transmembrane receptor protein tyrosine kinase (PTK) activated normally by forming ternary complexes with its cognate ligands and co-receptors. RET alterations by point mutations and gene fusions were found in diverse cancers. RET L730M is a mutant of RET. RET L730M Recombinant Human Active Protein Kinase is a recombinant RET L730M protein that can be used to study RET L730M-related functions .

RET R749T Recombinant Human Active Protein Kinase	RET	Cancer
Rearranged during transfection (RET) is a transmembrane receptor protein tyrosine kinase (PTK) activated normally by forming ternary complexes with its cognate ligands and co-receptors. RET alterations by point mutations and gene fusions were found in diverse cancers. RET R749T is a mutant of RET. RET R749T Recombinant Human Active Protein Kinase is a recombinant RET R749T protein that can be used to study RET R749T-related functions .

RET G810R Recombinant Human Active Protein Kinase	RET	Cancer
Rearranged during transfection (RET) is a transmembrane receptor protein tyrosine kinase (PTK) activated normally by forming ternary complexes with its cognate ligands and co-receptors. RET alterations by point mutations and gene fusions were found in diverse cancers. RET G810R is a mutant of RET. RET G810R Recombinant Human Active Protein Kinase is a recombinant RET G810R protein that can be used to study RET G810R-related functions .

RET E762Q Recombinant Human Active Protein Kinase	RET	Cancer
Rearranged during transfection (RET) is a transmembrane receptor protein tyrosine kinase (PTK) activated normally by forming ternary complexes with its cognate ligands and co-receptors. RET alterations by point mutations and gene fusions were found in diverse cancers. RET E762Q is a mutant of RET. RET E762Q Recombinant Human Active Protein Kinase is a recombinant RET E762Q protein that can be used to study RET E762Q-related functions .

Cat. No.	Product Name

HY-L150

Membrane Receptor-targeted Compound Library

6,186 compounds

Membrane receptors, also known cell surface receptors or transmembrane receptors, are transmembrane proteins embedded into the plasma membrane which play an essential role in maintaining communication between the internal processes within the cell and various types of extracellular signals. They act in cell signaling by receiving (binding to) extracellular molecules, which are also called ligands. These extracellular molecules include hormones, cytokines, growth factors, neurotransmitters, lipophilic signaling molecules such as prostaglandins, and cell recognition molecules.

There are three kinds of membrane receptors: ion channel-linked receptors, enzyme-linked receptors and G-protein-linked receptors. They play important roles in keeping human normal physiologic processes. GPCRs and ion channels are important drug targets in drug discovery.

MCE provides a unique collection of 6,186 compounds targeting a variety of membrane receptors. MCE Membrane reeptor-targeted Compound Library can be used for membrane receptor-focused screening and drug discovery.

HY-L016

Protein Tyrosine Kinase Compound Library

1,420 compounds

Protein tyrosine kinases (PTKs) are key signaling molecules and important drug targets. Two classes of PTKs are present in cells: the transmembrane receptor PTKs (RTKs) and the nonreceptor PTKs. The RTK family includes the receptors for insulin and for many growth factors, such as EGFR, FGFR, PDGFR, VEGFR, and NGFR. RTKs are transmembrane glycoproteins that are activated by the binding of their ligands, and they transduce the extracellular signal to the cytoplasm by phosphorylating tyrosine residues on the receptors themselves (autophosphorylation) and on downstream signaling proteins. Their principal functions of PTKs involve the regulation of multicellular aspects of the organism. Cell to cell signals concerning growth, differentiation, adhesion, motility, and death are frequently transmitted through tyrosine kinases. In humans, tyrosine kinases have been demonstrated to play significant roles in the development of many disease states, including diabetes and cancers.

MCE designs a unique collection of 1,420 compounds that act as a useful tool for PTKs-related drug screening and disease research.

HY-L008

JAK/STAT Compound Library

613 compounds

The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway is central to signaling by cytokine receptors, a superfamily of more than 30 transmembrane proteins that recognize specific cytokines, and is critical in blood formation and immune response. Canonical JAK/STAT signaling begins with the association of cytokines and their corresponding transmembrane receptors. Activated JAKs then phosphorylate latent STAT monomers, leading to dimerization, nuclear translocation, and DNA binding. In mammals, there are four JAKs (JAK1, JAK2, JAK3, TYK2) and seven STATs (STAT1, STAT2, STAT3, STAT4, STAT5a, STAT5b, STAT6). Since the JAK/STAT pathway plays a major role in many fundamental processes, such as apoptosis and inflammation, dysfunctional proteins in the pathway may lead to a number of diseases. For example, alterations in JAK/STAT signalling can result in cancer and diseases affecting the immune system, such as severe combined immunodeficiency disorder (SCID).

MCE provides 613 compounds that can be used in the study of the JAK/STAT signaling pathway and related diseases.

HY-L062

Neurotransmitter Receptor Compound Library

2,278 compounds

Neurotransmitter (NT) receptors, also known as neuroreceptors, are a broadly diverse group of membrane proteins that bind neurotransmitters for neuronal signaling. There are two major types of neurotransmitter receptors: ionotropic and metabotropic. Ionotropic receptors are ligand-gated ion channels, meaning that the receptor protein includes both a neurotransmitter binding site and an ion channel. The binding of a neurotransmitter molecule (the ligand) to the binding site induces a conformational change in the receptor structure, which opens, or gates, the ion channel. The term “metabotropic receptors” is typically used to refer to transmembrane G-protein-coupled receptors. Metabotropic receptors trigger second messenger-mediated effects within cells after neurotransmitter binding.

In some neurological diseases, the neurotransmitter receptor itself appears to be the target of the disease process. Many neuroactive drugs act by modifying neurotransmitter receptors. A better understanding of neurotransmitter receptor changes in disease may lead to improvements in therapy.

MCE designs a unique collection of 2,278 compounds targeting a variety of neurotransmitter receptors. MCE Neurotransmitter Receptor Compound Library is a useful tool for neurological diseases drug discovery.

Cat. No.	Product Name	Type

HY-148033

Trimethyl chitosan

N,N,N-Trimethylchitosan

Drug Delivery

Trimethyl chitosan (N,N,N-Trimethylchitosan) is a multifunctional polymer and a derivative of Chitosan (HY-B2144A). Trimethyl chitosan targets the absorption enhancing proteins of tight junctions of intestinal and mucosal epithelial cells, induces tight junction protein rearrangement, and increases intercellular permeability. Trimethyl chitosan can stimulate the activity of promoting transmembrane transport of hydrophilic drugs (such as peptides and proteins) and can be used for drug delivery and synthesis of nanoparticles .

HY-NP162

Recombinant Humanized Type XVII Collagen

Native Proteins

Recombinant Humanized Type XVII Collagen is a transmembrane protein that forms hemidesmosomes. Recombinant Humanized Type XVII Collagen facilitates interactions between stem cells，surrounding cells，and the extracellular matrix，thereby regulating skin homeostasis，aging，and wound healing. Recombinant Humanized Type XVII Collagen also possesses unique cell adhesion sites and signal transduction functions，which can regulate cell migration，proliferation，and differentiation .

HY-E70144

N-Acetylglucosaminyltransferase 1 EC:2.4.1.101; MGAT1	Enzyme Substrates
N-Acetylglucosaminyltransferase1 (EC:2.4.1.101, MGAT1) shows typical features of a type II transmembrane protein. N-Acetylglucosaminyltransferase1 is believed to be essential for normal embryogenesis .

Cat. No.	Product Name	Target	Research Area

HY-P0204A

Endothelin-3, human, mouse, rabbit, rat TFA 1 Publications Verification Endothelin 3 (Rat,Human) TFA	Endothelin Receptor	Cardiovascular Disease Neurological Disease
Endothelin-3, human, mouse, rabbit, rat TFA is a 21-amino acid vasoactive peptide that binds to G-protein-linked transmembrane receptors, ET-RA and ET-RB.

HY-P3333

KSPWFTTL	MHC	Inflammation/Immunology Cancer
KSPWFTTL is an immunodominant Kb-restricted epitope from the p15E transmembrane protein. KSPWFTTL can restore susceptibility of a tumor line to anti-AKR/Gross MuLV cytotoxic T lymphocytes .

HY-P3333A

KSPWFTTL TFA	MHC	Inflammation/Immunology Cancer
KSPWFTTL TFA is an immunodominant Kb-restricted epitope from the p15E transmembrane protein. KSPWFTTL TFA can restore susceptibility of a tumor line to anti-AKR/Gross MuLV cytotoxic T lymphocytes .

HY-P0207A

Endothelin-2 (49-69), human TFA Endothelin-2 (49-69) (human, canine) TFA; Human endothelin-2 TFA	Endothelin Receptor	Cardiovascular Disease Cancer
Endothelin-2 (49-69), human (TFA) (Endothelin-2 (49-69) (human, canine) (TFA)) is a 21-amino acid vasoactive peptide that binds to G-protein-linked transmembrane receptors, ET-RA and ET-RB.

HY-P1985

Notch 1	Notch	Cardiovascular Disease Cancer
Notch 1 (Notch homolog 1, translocation-associated) can encode a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple different domain types .

HY-P2508

MUC1, mucin core	Mucin	Cancer
MUC1, mucin core is the region of the MUC1 mucin core. MUC1 is a type I transmembrane glycoprotein, and is overexpressed and aberrantly glycosylated in carcinoma cells. MUC1, mucin core protein binds to domain 1 of ICAM-1 .

HY-P3051

CKS-17	Reverse Transcriptase	Inflammation/Immunology
CKS-17 is a synthetic retroviral envelope peptide. CKS-17 has the highly conserved amino acid sequences occurring within the transmembrane envelope protein of many animal and human retroviruses. CKS-17 acts as an immunomodulatory epitope and exhibits suppressive properties for numerous immune functions .

HY-P0204

Endothelin-3, human, mouse, rabbit, rat Endothelin 3 (Rat,Human)	G Protein-coupled Receptor Kinase (GRK)	Cardiovascular Disease Neurological Disease
Endothelin-3, human, mouse, rabbit, rat is a 21-amino acid vasoactive peptide that binds to G-protein-linked transmembrane receptors, ET-RA and ET-RB.

HY-P0207

Endothelin-2 (49-69), human Endothelin-2 (human, canine); Human endothelin-2	Endothelin Receptor	Cardiovascular Disease Cancer
Endothelin-2 (49-69), human (Endothelin-2 (human, canine)) is a 21-amino acid vasoactive peptide that binds to G-protein-linked transmembrane receptors, ET-RA and ET-RB.

HY-P1985A

Notch 1 TFA	Notch	Cardiovascular Disease Cancer
Notch 1 TFA (Notch homolog 1, translocation-associated) can encode a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple different domain types .

HY-P10716

Exendin-P5	GLP Receptor	Metabolic Disease
Exendin-P5 is a selective agonist that targets the GLP-1R. Exendin-P5 promotes rapid activation of G proteins by transient interactions with the transmembrane domain of GLP-1R, enhancing its potency in G protein-mediated signaling and accelerating cAMP production. This mechanism suggests the potential application of Exendin-P5 in the study of metabolic diseases .

HY-P10495

GPR110 peptide agonist P12	Transmembrane Glycoprotein	Others Cancer
GPR110 peptide agonist P12 is a peptide that acts as a GPR110 agonist. GPR110 peptide agonist P12 can significantly enhance the initial rate of GPR110 stimulated G protein GTPγS binding. GPR110 peptide agonist P12 mimics the action of natural ligands, causing the extracellular domain (ECD) of the GPR110 to dissociate from the seven transmembrane domains (7TM), exposing the β-strand-13/stalk region at the N-terminus of the 7TM domain, which acts as an agonist to activate G protein signaling. GPR110 peptide agonist P12 can be used in the study of developmental disorders and cancers related to GPR110 .

HY-P10495A

GPR110 peptide agonist P12 acetate	Peptides	Cancer
GPR110 peptide agonist P12 acetate is the acetate salt form of GPR110 peptide agonist P12 (HY-P10495). GPR110 peptide agonist P12 acetateis a peptide that acts as a GPR110 agonist. GPR110 peptide agonist P12 acetate can significantly enhance the initial rate of GPR110 stimulated G protein GTPγS binding. GPR110 peptide agonist P12 acetate mimics the action of natural ligands, causing the extracellular domain (ECD) of the GPR110 to dissociate from the seven transmembrane domains (7TM), exposing the β-strand-13/stalk region at the N-terminus of the 7TM domain, which acts as an agonist to activate G protein signaling. GPR110 peptide agonist P12 acetate can be used in the study of developmental disorders and cancers related to GPR110 .

HY-P1925A

GO-203 TFA 2 Publications Verification	PI3K Reactive Oxygen Species (ROS) Apoptosis	Cancer
GO-203 TFA is a potent MUC1-C oncoprotein inhibitor. GO-203 TFA is an all D-amino acid peptide that consists of a poly-R transduction domain linked to a CQCRRKN motif that binds to the MUC1-C cytoplasmic tail and blocks MUC1-C homodimerization. GO-203 TFA downregulates TIGAR (TP53-induced glycolysis and apoptosis regulator) protein synthesis by inhibiting the PI3K-AKT-S6K1 pathway. GO-203 TFA induces the production of ROS and loss of mitochondrial transmembrane potential. GO-203 TFA inhibits the growth of colon cancer cells in vitro and as xenografts in nude mice .

Cat. No.	Product Name	Target	Research Area

HY-P9976

Isatuximab 1 Publications Verification ch38SB19; hu38SB19; SAR-650984	Apoptosis	Cancer
Isatuximab is a monoclonal antibody targeting the transmembrane receptor and ectoenzyme CD38, a protein highly expressed on hematological malignant cells, including those in multiple myeloma (MM). Isatuximab has antitumor activity via multiple biological mechanisms, including antibody-dependent cellular-mediated cytotoxicity, complement-dependent cytotoxicity, antibody-dependent cellular phagocytosis, and direct induction of apoptosis without crosslinking. Isatuximab also directly inhibits CD38 ectoenzyme activity, which is implicated in many cellular functions .

HY-P99172

CC-90002	CD47 Interleukin Related	Cancer
CC-90002 is a humanized anti-CD47 monoclonal antibody (mAb). CC-90002 has a high affinity for binding to CD47 with a subnanomolar K_d value. CC-90002 can be used for the research of hematologic malignancies and solid tumors .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N3540

Caraphenol A	Leguminosae Phenols Polyphenols Plants Caragana sinica (Buchoz) Rehd.	Others
Caraphenol A is a resveratrol trimer and is able to transiently reduce *interferon-induced transmembrane* (IFITM)** protein expression. Caraphenol A safely enhances lentiviral vector gene delivery to hematopoietic stem and progenitor cells . Caraphenol A also inhibits human cystathionine β-synthase (hCBS) and human cystathionine γ- lyase (hCSE) with IC₅₀s of 5.9 μM and 12.1 μM, respectively .

HY-N0247

Saikosaponin B1 2 Publications Verification	Classification of Application Fields Source classification Umbelliferae Plants Disease Research Fields Saccharides Monosaccharides Carphephorus corymbosus (Nutt.) Torr. & A.Gray Cancer	Hedgehog Smo STAT Interleukin Related TNF Receptor
Saikosaponin B1 is a bioactive constituent of Radix Bupleuri. Saikosaponin B1 is an agonist of the 5-HT_2C receptor with an EC₅₀ of 147.41 μM. Saikosaponin B1 inhibits the Hedgehog (Hh) signaling pathway by targeting the transmembrane protein SMO. Sailosaponin B1 can reduce liver fibrosis. Saikosaponin B1 has anti-cancer activities thus can be studies in research for cancers such as Medulloblastoma (MB) .

HY-12326A

c-di-AMP disodium Maximum Cited Publications 8 Publications Verification Cyclic diadenylate disodium; Cyclic-di-AMP disodium	Natural Products Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	STING Bacterial Endogenous Metabolite
c-di-AMP (Cyclic diadenylate) sodium is a STING agonist, which binds to the transmembrane protein STING thereby activating the TBK3-IRF3 signaling pathway, subsequently triggering the production of type I IFN and TNF. c-di-AMP sodium is also a bacterial second messenger, which regulates cell growth, survival, and virulence, primarily within Gram-positive bacteria, and also regulates host immune response. c-di-AMP sodium acts as a potent mucosal adjuvant stimulating both humoral and cellular responses .

HY-12326B

c-di-AMP diammonium Maximum Cited Publications 8 Publications Verification Cyclic diadenylate diammonium; Cyclic-di-AMP diammonium	Natural Products Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	STING Bacterial Endogenous Metabolite
c-di-AMP diammonium is a STING agonist, which binds to the transmembrane protein STING thereby activating the TBK3-IRF3 signaling pathway, subsequently triggering the production of type I IFN and TNF. c-di-AMP diammonium is also a bacterial second messenger, which regulates cell growth, survival, and virulence, primarily within Gram-positive bacteria, and also regulates host immune response. c-di-AMP diammonium acts as a potent mucosal adjuvant stimulating both humoral and cellular responses .

HY-N10661

Ipomoeassin F Ipom-F	Natural Products Ipomoea squamosa Choisy Plants Convolvulaceae	SARS-CoV
Ipomoeassin F is a potent and selective endoplasmic reticulum (ER) protein-translocation inhibitor by targeting the pore-forming subunit of the Sec61 complex (Sec61α) at the ER membrane. Ipomoeassin F selectively inhibits the ER membrane translocation of SARS-CoV-2 proteins. Ipomoeassin F block the ER translocation of secretory proteins and type I transmembrane proteins (TMPs), but not type III TMPs .

HY-N6776R

Penitrem A (Standard)	Microorganisms Terpenoids Source classification Diterpenoids	Reference Standards Potassium Channel
Prenylamine (lactate) (Standard) is the analytical standard of Prenylamine (lactate). This product is intended for research and analytical applications. Prenylamine lactate is a calcium-modulating protein (CaM) antagonist that inhibits CaM-dependent enzymes and can slowly relax smooth muscle preparations. The effect of Prenylamine lactate on smooth muscle is not inhibited by the calcium agonist Bay K 8644 (HY-10588). Reports suggest that under low heart rate conditions, Prenylamine seems to enhance voltage-dependent transmembrane calcium currents .

HY-12326

c-di-AMP Cyclic diadenylate; Cyclic-di-AMP	Natural Products Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	STING Bacterial Endogenous Metabolite
c-di-AMP (Cyclic diadenylate) is a STING agonist, which binds to the transmembrane protein STING thereby activating the TBK3-IRF3 signaling pathway, subsequently triggering the production of type I IFN and TNF. c-di-AMP (Cyclic diadenylate) is also a bacterial second messenger, which regulates cell growth, survival, and virulence, primarily within Gram-positive bacteria, and also regulates host immune response. c-di-AMP (Cyclic diadenylate) acts as a potent mucosal adjuvant stimulating both humoral and cellular responses .

HY-N0247R

Saikosaponin B1 (Standard)	Source classification Umbelliferae Plants Saccharides Monosaccharides Carphephorus corymbosus (Nutt.) Torr. & A.Gray	Reference Standards Smo
Saikosaponin B1 (Standard) is the analytical standard of Saikosaponin B1. This product is intended for research and analytical applications. Saikosaponin B1 is a bioactive constituent of Radix Bupleuri. Saikosaponin B1 is an agonist of the 5-HT_2C receptor with an EC₅₀ of 147.41 μM. Saikosaponin B1 inhibits the Hedgehog (Hh) signaling pathway by targeting the transmembrane protein SMO. Sailosaponin B1 can reduce liver fibrosis. Saikosaponin B1 has anti-cancer activities thus can be studies in research for cancers such as Medulloblastoma (MB) .

Species:	Human (75) Mouse (16) Bovine (1) Rat (1) Cynomolgus (6)
Tag:	His (67) SUMO (2) Tag Free (2) Avi (5) Myc (2) GST (1) MBP (1) Fc (29) Flag (1)
Source:	HEK293 (81) E. coli Cell-free (2) CHO (1) CHO (1) P. pastoris (2) Sf9 insect cells (1) E. coli (11)

Cat. No.	Compare	Product Name	Species	Source

HY-P70836

	GPNMB/Osteoactivin Protein, Human (HEK293, His) transmembrane Glycoprotein NMB; transmembrane Glycoprotein HGFIN; GPNMB; HGFIN; NMB	Human	HEK293
	GPNMB, also known as osteoactivin, is a protein thought to have a potential role as a melanin-producing enzyme. Melanogenic enzymes are involved in the production of melanin, the pigment that determines skin, hair and eye color. GPNMB/Osteoactivin Protein, Human (HEK293, His) is the recombinant human-derived GPNMB/Osteoactivin protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P70201

	FLRT2 Protein, Human (HEK293, His) rHuLeucine-rich repeat transmembrane protein FLRT2/FLRT2, His; Leucine-Rich Repeat transmembrane protein FLRT2; Fibronectin-Like Domain-Containing Leucine-Rich transmembrane protein 2; FLRT2; KIAA0405	Human	HEK293
	FLRT2 protein is involved in cell-cell adhesion, migration, and axonal guidance through various interactions.It promotes adhesion by binding to ADGRL3 and potentially other sloth proteins.FLRT2 Protein, Human (HEK293, His) is the recombinant human-derived FLRT2 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P70925

	FLRT1 Protein, Human (HEK293, His) Leucine-Rich Repeat transmembrane protein FLRT1; Fibronectin-Like Domain-Containing Leucine-Rich transmembrane protein 1; FLRT1	Human	HEK293
	FLRT1 is a key player in FGF-mediated signaling, activating MAP kinase and enhancing neurite outgrowth through FGFR1-mediated signaling.It helps increase the number and length of neurites. FLRT1 Protein, Human (HEK293, His) is the recombinant human-derived FLRT1 protein, expressed by HEK293 , with C-His labeled tag.

HY-P77244

	TMEM156 Protein, Human (HEK293, His) transmembrane protein 156; TMEM156	Human	HEK293
	TMEM156 Protein is a member of transmembrane proteins (TMEM) family. The expression levels of TMEM156 correlates with patient survival. TMEM156 is upregulated in tumor tissue. Many genes positively correlated with TMEM156 are involved in multiple immunological processes. Furthermore, genes negatively correlated with TMEM156 are linked with RHO GTPase effectors, which results in a poorer response to receptor activation, thus reducing cancer cell proliferation, survival, and migration. TMEM156 Protein, Human (HEK293, His) is the recombinant human-derived TMEM156 protein, expressed by HEK293 , with C-His labeled tag.

HY-P77245

	TMEM25 Protein, Human (HEK293, His) transmembrane protein 25; TMEM25	Human	HEK293
	TMEM25 Protein, crucial in neurons, modulates the degradation of the NMDA receptor GRIN2B subunit, influencing the intricate regulation of neuronal excitability. Its interaction with GRIN2B highlights its role in dynamic processes central to neurotransmission and synaptic function. TMEM25 Protein, Human (HEK293, His) is the recombinant human-derived TMEM25 protein, expressed by HEK293 , with C-His labeled tag.

HY-P70924

	FLRT3 Protein, Human (HEK293, His) Leucine-Rich Repeat transmembrane protein FLRT3; Fibronectin-Like Domain-Containing Leucine-Rich transmembrane protein 3; FLRT3; KIAA1469	Human	HEK293
	The FLRT3 protein exhibits multiple roles in cellular processes, affecting cell-cell adhesion, migration, and axonal guidance, with context-dependent attraction or repulsion.FLRT3 is critical for the spatial organization of brain neurons and also contributes to retinal blood vessel development.FLRT3 Protein, Human (HEK293, His) is the recombinant human-derived FLRT3 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P705492

	TMEM165 Protein, Human TMEM165; TPARL; transmembrane protein 165; transmembrane protein PT27; transmembrane protein TPARL	Human	E. coli

HY-P76481

	LRRTM4 Protein, Human (HEK293, His) Leucine-rich repeat transmembrane neuronal protein 4	Human	HEK293
	The LRRTM4 protein plays a critical role in the development and maintenance of the vertebrate nervous system, particularly in synaptogenesis and differentiation of excitatory presynaptic elements. LRRTM4 is associated with the AMPA receptor (AMPAR) complex, is located at the periphery of the complex, interacts directly with GluA/GRIA proteins, and helps coordinate the complex network of AMPAR complex assembly and function. LRRTM4 Protein, Human (HEK293, His) is the recombinant human-derived LRRTM4 protein, expressed by HEK293 , with C-His labeled tag.

HY-P77069

	LRRTM4 Protein, Mouse (HEK293, His) Leucine-rich repeat transmembrane neuronal protein 4	Mouse	HEK293
	LRRTM4 protein is crucial for vertebrate nervous system development and maintenance. It exhibits synaptogenic activity, limited to excitatory presynaptic differentiation. LRRTM4 is associated with the AMPAR complex, regulating AMPAR complex function and synaptic processes. Understanding LRRTM4's interactions within the complex could offer insights into its role in synaptic regulation and neural connectivity. LRRTM4 Protein, Mouse (HEK293, His) is the recombinant mouse-derived LRRTM4 protein, expressed by HEK293 , with C-His labeled tag.

HY-P77068

	LRRTM3 Protein, Mouse (CHO, His) Leucine-rich repeat transmembrane neuronal protein 3; LRRTM3	Mouse	CHO
	The LRRTM3 protein may contribute to the development and maintenance of the vertebrate nervous system, and in vitro studies highlight its synaptic activity. LRRTM3 specifically affects the differentiation of excitatory presynaptic elements, emphasizing its role in shaping synaptic connections associated with excitatory neurotransmission. LRRTM3 Protein, Mouse (CHO, His) is the recombinant mouse-derived LRRTM3 protein, expressed by CHO , with C-His labeled tag.

HY-P77246

	Collectrin/TMEM27 Protein, Human (HEK293, Fc) Collectrin; transmembrane protein 27; CLTRN; TMEM27	Human	HEK293
	Collectrin, also known as TMEM27, plays a key role in amino acid transport by binding to SLC6A18 and SLC6A19 and regulating their surface trafficking and amino acid transporter activity. Suggested to facilitate the trafficking of SLC3A1 and SLC7A9 to the renal cortical cell membrane. Collectrin/TMEM27 Protein, Human (HEK293, Fc) is the recombinant human-derived Collectrin/TMEM27 protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P77247

	TMIGD1 Protein, Human (HEK293, His) transmembrane and immunoglobulin domain-containing protein 1; TMIGD	Human	HEK293
	TMIGD1 is a potential regulator that affects multiple cellular processes, including adhesion, migration, proliferation, and morphology. Its protective effect against oxidative damage in renal epithelial cells promotes cell survival. TMIGD1 Protein, Human (HEK293, His) is the recombinant human-derived TMIGD1 protein, expressed by HEK293 , with C-His labeled tag.

HY-P77248

	TMIGD1 Protein, Human (HEK293, Fc) transmembrane and immunoglobulin domain-containing protein 1; TMIGD	Human	HEK293
	TMIGD1 is a potential regulator that affects multiple cellular processes, including adhesion, migration, proliferation, and morphology. Its protective effect against oxidative damage in renal epithelial cells promotes cell survival. TMIGD1 Protein, Human (HEK293, Fc) is the recombinant human-derived TMIGD1 protein, expressed by HEK293 , with C-mFc labeled tag.

HY-P76256

	CHODL Protein, Mouse (HEK293, His) Chondrolectin; transmembrane protein MT75; C21orf68	Mouse	HEK293
	CHODL proteins contribute significantly to nervous system development, particularly in neurite growth and elongation. There is evidence that it is involved in guiding motor axon growth and shaping the structural framework of the nervous system. CHODL Protein, Mouse (HEK293, His) is the recombinant mouse-derived CHODL protein, expressed by HEK293 , with C-His labeled tag.

HY-P77854

	TMEM106B Protein, Mouse (HEK293, Fc) transmembrane protein 106B; Tmem106b	Mouse	HEK293
	The TMEM106B protein is a key player in neurons involved in trafficking to late endosomes/lysosomes and potentially affects dendritic morphogenesis and maintenance by regulating lysosomal trafficking. It may act as a molecular brake on retrograde transport by interacting with MAP6. TMEM106B Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived TMEM106B protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P76681

	TMX1 Protein, Human (HEK293, Fc) Thioredoxin-related transmembrane protein 1; TMX; TXNDC; TXNDC1	Human	HEK293
	TMX1 Protein is a member of the protein disulfide isomerase (PDI) family and is a transmembrane thiol isomerase. TMX1 Protein can participate in various redox reactions, reversibly oxidizes to disulfide through its active center thiol, and catalyzes the thiol-disulfide exchange reaction. In addition, TMX1 Protein negatively regulates the activation of αibβ3 integrin and platelet aggregation outside the cell. TMX1 Protein, Human (HEK293, Fc) is the recombinant human-derived TMX1 protein, expressed by HEK293 , with C-mFc labeled tag.

HY-P704155

	TMEM119 Protein, Human (P. pastoris, His) TMEM119; transmembrane protein 119; Osteoblast induction factor (OBIF)	Human	P. pastoris
	The TMEM119 protein is critical in bone formation and helps myoblasts differentiate into osteoblasts. It induces commitment and differentiation by enhancing BMP2 production and interacting with the BMP-RUNX2 pathway. TMEM119 Protein, Human (P. pastoris, His) is the recombinant human-derived TMEM119 protein, expressed by P. pastoris, with N-6*His labeled tag.

HY-P77116

	GPNMB/Osteoactivin Protein, Mouse (HEK293, His) transmembrane Glycoprotein NMB; GPNMB; HGFIN; NMB	Mouse	HEK293
	GPNMB/bone active protein shows promise as a melanogenic enzyme, possibly involved in melanin synthesis. Its regulatory influence on melanin production highlights its critical role in pigment formation. GPNMB/Osteoactivin Protein, Mouse (HEK293, His) is the recombinant mouse-derived GPNMB/Osteoactivin protein, expressed by HEK293 , with C-His labeled tag.

HY-P702377

	MFN2 Protein, Human (Cell-Free, His) Mitofusin-2; transmembrane GTPase MFN2	Human	E. coli Cell-free
	MFN2 is a mitochondrial outer membrane GTPase that regulates mitochondrial dynamics, balancing fusion and fission to achieve dynamic organelle morphology. Its overexpression forms an extensive mitochondrial network, highlighting its organizational role. MFN2 Protein, Human (Cell-Free, His) is the recombinant human-derived MFN2 protein, expressed by E. coli Cell-free , with N-10*His labeled tag.

HY-P70203

	LRRTM2 Protein, Human (HEK293, His) rHuLeucine-rich repeat transmembrane neuronal protein 2/LRRTM2, His; Leucine-Rich Repeat transmembrane Neuronal protein 2; Leucine-Rich Repeat Neuronal 2 protein; LRRTM2; KIAA0416; LRRN2	Human	HEK293
	The LRRTM2 protein is critical for developing and maintaining excitatory synapses, regulating AMPA receptor surface expression, and directing the formation of functional glutamate release sites for synaptic efficacy.LRRTM2 serves as a ligand for presynaptic receptors NRXN1-A and NRXN1-B and participates in transsynaptic signaling.LRRTM2 Protein, Human (HEK293, His) is the recombinant human-derived LRRTM2 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P71629

	Collectrin/TMEM27 Protein, Mouse (Myc, His-SUMO) Cltrn; Nx17; Tmem27Collectrin; transmembrane protein 27	Mouse	E. coli
	The Collectrin protein plays a crucial role in amino acid transport by binding to SLC6A18 and SLC6A19 and regulating their surface transport and activity. Furthermore, it may affect the trafficking of SLC3A1 and SLC7A9 to the renal cortical cell membrane. Collectrin/TMEM27 Protein, Mouse (Myc, His-SUMO) is the recombinant mouse-derived Collectrin protein, expressed by E. coli , with N-His, C-Myc, N-SUMO labeled tag.

HY-P77251

	TMUB2 Protein, Human (HEK293, His) transmembrane and ubiquitin-like domain-containing protein 2; TMUB2	Human	HEK293
	TMUB2 Protein is a poorly characterized TMUB1 paralog. TMUB2 is a part of various ERAD complexes. In addition, it is a component of the membrane that has transmembrane function. TMUB2 is related to TP53 protein expression. TMUB2 expression increases with age in skin, adipose tissue, blood, and brain and is associated with cancer initiation and progression. TMUB2 Protein, Human (HEK293, His) is the recombinant human-derived TMUB2 protein, expressed by HEK293 , with N-His labeled tag.

HY-P71281

	SECTM1 Protein, Human (HEK293, His) Secreted and transmembrane protein 1; protein K-12; SECTM1; K12	Human	HEK293
	SECTM1 Protein potentially influences thymocyte signaling, indicating a role in thymic regulatory mechanisms. Its interaction with CD7 suggests involvement in cellular processes, potentially influencing thymocyte-associated signaling pathways. SECTM1's significance in thymocyte function and interaction with CD7 hints at a role in modulating immune responses and cellular communication within the thymic microenvironment. SECTM1 Protein, Human (HEK293, His) is the recombinant human-derived SECTM1 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P76934

	FLRT2 Protein, Mouse (HEK293, His) Leucine-rich repeat transmembrane protein FLRT2; Flrt2; Kiaa0405	Mouse	HEK293
	The FLRT2 protein plays a key role in cell-cell adhesion, migration, and axonal guidance. Its interaction with ADGRL3 promotes cell-cell adhesion and promotes cortical neuronal migration through interaction with UNC5D. FLRT2 Protein, Mouse (HEK293, His) is the recombinant mouse-derived FLRT2 protein, expressed by HEK293 , with C-His labeled tag.

HY-P76531

	OSTM1 Protein, Human (HEK293, His) Osteopetrosis-associated transmembrane protein 1; Chloride channel 7 beta subunit; GL	Human	HEK293
	The OSTM1 protein is indispensable for the maturation and function of osteoclasts and melanocytes. It forms a heteromer with CLCN7, with CLCN7 as the α subunit and OSTM1 as the β subunit. OSTM1 Protein, Human (HEK293, His) is the recombinant human-derived OSTM1 protein, expressed by HEK293 , with C-His labeled tag.

HY-P77117

	OSTM1 Protein, Mouse (HEK293, His) Osteopetrosis-associated transmembrane protein 1; Chloride channel 7 beta subunit; GL	Mouse	HEK293
	OSTM1 Protein is crucial for osteoclast and melanocyte maturation and function, forming heteromers with alpha subunits (CLCN7) to create chloride channel 7. OSTM1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived OSTM1 protein, expressed by HEK293 , with C-His labeled tag.

HY-P700470

	TMEFF2/Tomoregulin-2 Protein, Human (HEK293, His) TMEFF2; transmembrane protein with EGF like and two follistatin like domains 2; TR; HPP1; TPEF; TR-2; TENB2; CT120.2; tomoregulin-2; cancer/testis antigen family 120, member 2; hyperplastic polyposis protein 1; transmembrane protein TENB2; transmembrane protein with EGF-like and two follistatin-like domains	Human	HEK293
	TMEFF2/Tomoregulin-2 protein serves as a potential survival factor for hippocampal and midbrain neurons, supporting neuronal cell viability.In addition, its shed form may upregulate cancer cell proliferation by promoting ERK1/2 phosphorylation.TMEFF2/Tomoregulin-2 Protein, Human (HEK293, His) is the recombinant human-derived TMEFF2/Tomoregulin-2 protein, expressed by HEK293 , with C-10*His labeled tag.

HY-P75950

	GPNMB/Osteoactivin Protein, Human (Isoform 2, HEK293, His) transmembrane Glycoprotein NMB; GPNMB; HGFIN; NMB	Human	HEK293
	GPNMB, also known as osteoactivin, is a protein thought to have a potential role as a melanin-producing enzyme. Melanogenic enzymes are involved in the production of melanin, the pigment that determines skin, hair and eye color. GPNMB/Osteoactivin Protein, Human (Isoform 2, HEK293, His) is the recombinant human-derived GPNMB/Osteoactivin protein, expressed by HEK293 , with C-His labeled tag.

HY-P75951

	GPNMB/Osteoactivin Protein, Human (Isoform 2, HEK293, Fc) transmembrane Glycoprotein NMB; GPNMB; HGFIN; NMB	Human	HEK293
	GPNMB, also known as osteoactivin, is a protein thought to have a potential role as a melanin-producing enzyme. Melanogenic enzymes are involved in the production of melanin, the pigment that determines skin, hair and eye color. GPNMB/Osteoactivin Protein, Human (Isoform 2, HEK293, Fc) is the recombinant human-derived GPNMB/Osteoactivin protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P71443

	VSTM5 Protein, Human (His) Chromosome 11 open reading frame 90; CK090 HUMAN; Uncharacterized protein C11orf90; V set and transmembrane domain containing 5; V-set and transmembrane domain-containing protein 5	Human	E. coli
	The VSTM5 protein acts as a cell adhesion-like membrane protein in the central nervous system (CNS) and exerts a critical influence on the positioning and complexity of central neurons by regulating their membrane morphology and dynamics. It is actively involved in the formation of neuronal dendrites and protrusions, including dendritic filopodia, contributing to the complex structure of neural networks. VSTM5 Protein, Human (His) is the recombinant human-derived VSTM5 protein, expressed by E. coli , with N-His labeled tag.

HY-P73390

	ROR1 Protein, Human (sf9, His) Inactive tyrosine-protein kinase transmembrane receptor ROR1; ROR1; NTRKR1	Human	Sf9 insect cells
	ROR1 protein's minimal kinase activity in vitro suggests an improbable role as a tyrosine kinase in vivo. It serves as a receptor for WNT5A, activating NFkB signaling and potentially inhibiting WNT3A signaling. Notably, ROR1 plays a vital role in the inner ear, facilitating innervation of auditory hair cells by spiral ganglion neurons. ROR1 Protein, Human (sf9, His) is the recombinant human-derived ROR1 protein, expressed by Sf9 insect cells , with C-His labeled tag.

HY-P77087

	MMGT1 Protein, Human (HEK293, His) ER membrane protein complex subunit 5; transmembrane protein 32; EMC5; TMEM32	Human	HEK293
	The MMGT1 protein is an important member of the endoplasmic reticulum membrane protein complex (EMC) and is essential for the independent insertion of newly synthesized membrane proteins into the endoplasmic reticulum (ER) membrane. Its preference for transmembrane domains with weak hydrophobicity or unstable characteristics guides co- and post-translational insertion processes. MMGT1 Protein, Human (HEK293, His) is the recombinant human-derived MMGT1 protein, expressed by HEK293 , with N-His labeled tag.

HY-P77370

	IFITM3/Fragilis Protein, Human (HEK293, Fc) Interferon-induced transmembrane protein 3; DSPA2b; Interferon-inducible protein 1-8U	Human	HEK293
	IFITM3/Fragilis protein, a member of the IFITM family, has antiviral properties. It impedes the entry of viral pathogens, including influenza A, Ebola, and SARS-CoV-2, into cells. This protein is ubiquitously expressed in various tissues, such as the liver (RPKM 370.9) and placenta (RPKM 358.2), among others. IFITM3/Fragilis Protein, Human (HEK293, Fc) is the recombinant human-derived IFITM3/Fragilis protein, expressed by HEK293 , with N-mFc labeled tag.

HY-P77430

	KCT2 Protein, Human (HEK293, His) Keratinocyte-associated transmembrane protein 2; KCT2; C5orf15; HTGN29	Human	HEK293
	KCT2 protein, widely expressed across diverse tissues and cell types, indicates potential involvement in various physiological processes, highlighting its ubiquity within the biological landscape. KCT2 Protein, Human (HEK293, His) is the recombinant human-derived KCT2 protein, expressed by HEK293 , with C-His labeled tag.

HY-P77157

	PRRG2 Protein, Human (HEK293, Fc) transmembrane gamma-carboxyglutamic acid protein 2; Proline-rich Gla protein 2; PRGP2; TMG2	Human	HEK293
	PRRG2 protein interacts with NEDD4, suggesting a role in cellular regulation. In addition, it associates with the transcriptional coactivator YAP1, suggesting a possible involvement in transcriptional regulation. PRRG2 Protein, Human (HEK293, Fc) is the recombinant human-derived PRRG2 protein, expressed by HEK293 , with C-mFc labeled tag.

HY-P704211

	TMCO1 Protein, Human (Cell-Free, His) TMCO1; TMCC4; PNAS-10; PNAS-136; UNQ151/PRO177; Calcium load-activated calcium channel; CLAC channel; transmembrane and coiled-coil domain-containing protein 1; transmembrane and coiled-coil domains protein 4; Xenogeneic cross-immune protein PCIA3	Human	E. coli Cell-free
	TMCO1 Protein, Human (Cell-Free, His) is the recombinant human-derived TMCO1 protein, expressed by E. coli cell-free system, with N-10*His tag.

HY-P71371

	TMX2 Protein, Human (His) Thioredoxin-related transmembrane protein 2; Cell proliferation-inducing gene 26 protein; Thioredoxin domain-containing protein 14; TMX2	Human	E. coli
	The TMX2 protein is an endoplasmic reticulum- and mitochondria-associated regulator that controls cellular redox status and affects post-translational modifications, protein folding, and mitochondrial activity. TMX2 Protein, Human (His) is the recombinant human-derived TMX2 protein, expressed by E. coli , with N-6*His labeled tag.

HY-P71360

	THSD1 Protein, Human (HEK293, His) Thrombospondin Type-1 Domain-Containing protein 1; transmembrane Molecule with Thrombospondin Module; THSD1; TMTSP	Human	HEK293
	THSD1 Protein positively regulates nascent focal adhesion assembly, influencing endothelial cell attachment to the extracellular matrix. It forms a complex with PTK2/FAK1, TLN1, and VCL, interacting specifically with TLN1. THSD1 Protein, Human (HEK293, His) is the recombinant human-derived THSD1 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P71604

	Transmembrane protease serine 4 Protein, Mouse (His-SUMO) Tmprss4; Cap2; transmembrane protease serine 4; EC 3.4.21.-; Channel-activating protease 2; mCAP2	Mouse	E. coli
	The transmembrane protease serine 4 (TMPRSS4) protein is a plasma membrane-anchored serine protease that is critical for activating molecular pathways. Its proteolytic activity directly processes pro-uPA/PLAU into its active form. Transmembrane protease serine 4 Protein, Mouse (His-SUMO) is the recombinant mouse-derived Transmembrane protease serine 4 protein, expressed by E. coli , with N-His, N-SUMO labeled tag.

HY-P77242

	TMED4 Protein, Human (HEK293, His) transmembrane emp24 domain-containing protein 4; ERS25; GMP25iso; p24alpha3	Human	HEK293
	The TMED4 protein is complexly involved in vesicular protein trafficking in the early secretory pathway, which is critical for targeting and maintenance of the Golgi apparatus. Its involvement extends to the biosynthesis of secretions, emphasizing its role in processing. TMED4 Protein, Human (HEK293, His) is the recombinant human-derived TMED4 protein, expressed by HEK293 , with C-His labeled tag.

HY-P77243

	TMED4 Protein, Human (HEK293, Fc) transmembrane emp24 domain-containing protein 4; ERS25; GMP25iso; p24alpha3	Human	HEK293
	The TMED4 protein is complexly involved in vesicular protein trafficking in the early secretory pathway, which is critical for targeting and maintenance of the Golgi apparatus. Its involvement extends to the biosynthesis of secretions, emphasizing its role in processing. TMED4 Protein, Human (HEK293, Fc) is the recombinant human-derived TMED4 protein, expressed by HEK293 , with C-mFc labeled tag.

HY-P76680

	TMPRSS11D Protein, Human (HEK293, His) transmembrane protease serine 11D; Airway trypsin-like protease; HAT	Human	HEK293
	The TMPRSS11D protein is associated with host mucosal defense and acts synergistically with substances in the airway mucosa. It critically processes ACE2, activating the human coronavirus 229E spike glycoprotein to achieve virus-cell membrane fusion. TMPRSS11D Protein, Human (HEK293, His) is the recombinant human-derived TMPRSS11D protein, expressed by HEK293 , with N-His labeled tag.

HY-P71429

	VSTM2A Protein, Human ( E84K, HEK293, His) V-set and transmembrane domain-containing protein 2A; VSTM2	Human	HEK293
	The VSTM2A protein is a key player in early white and brown preadipocyte differentiation and actively promotes adipogenesis by upregulating the transcription factor PPARG. This regulation operates in BMP4-dependent signaling pathways, highlighting the complex molecular mechanisms involved in differentiation. VSTM2A Protein, Human ( E84K, HEK293, His) is the recombinant human-derived VSTM2A protein, expressed by HEK293 , with C-6*His labeled tag and E84K mutation.

HY-P77282

	VSTM1 Protein, Human (HEK293, Fc) V-set and transmembrane domain-containing protein 1; SIRL-1; Signal inhibitory receptor on leukocytes-1; VSTM1	Human	HEK293
	VSTM1 interacts with S100A10 protein, inducing the dimerization of ANXA2/p36. This suggests a regulatory role in protein phosphorylation, with ANXA2 monomer being the preferred target for tyrosine-specific kinase in vitro. The resulting heterotetramer comprises two light chains of S100A10/p11 and two heavy chains of ANXA2/p36. Furthermore, VSTM1 engages with SCN10A and TASOR, indicating its participation in diverse molecular interactions. VSTM1 Protein, Human (HEK293, Fc) is the recombinant human-derived VSTM1 protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P77396

	IGFLR1 Protein, Human (HEK293, Fc) IGF-like family receptor 1; transmembrane protein 149; TMEM149; U2AF1L4	Human	HEK293
	IGFLR1 protein, a probable cell membrane receptor, exhibits specific affinity for IGF-like family proteins IGFL1 and IGFL3, with higher binding affinity compared to others. This selective interaction profile suggests a key role for IGFLR1 in mediating cellular responses to these ligands, emphasizing its significance in the intricate network of cellular signaling pathways. IGFLR1 Protein, Human (HEK293, Fc) is the recombinant human-derived IGFLR1 protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P71370

	TMIGD2 Protein, Human (HEK293, His) transmembrane and immunoglobulin domain-containing protein 2; Immunoglobulin and proline-rich receptor 1; IGPR1; TMIGD2	Human	HEK293
	TMIGD2 is a multifaceted protein actively involved in cellular processes, including cell-cell interactions, migration, and angiogenesis. Its interaction with HHLA2 enhances T cell proliferation and cytokine production through AKT-dependent signaling during TCR-mediated activation. TMIGD2 Protein, Human (HEK293, His) is the recombinant human-derived TMIGD2 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P76678

	TMED9 Protein, Human (HEK293, His) transmembrane emp24 domain-containing protein 9; GMP25; p24alpha2; p25; GP25L2	Human	HEK293
	TMED9 is a key player in vesicle protein trafficking and plays an important role in the early secretory pathway, particularly in COPI vesicle-mediated retrograde transport. It promotes the recruitment of coat isoforms to the membrane, enhances ARFGAP2 activity, and ensures the specific retention of p24 complexes in cis-Golgi membranes, specifically affecting TMED2 and TMED10 localization. TMED9 Protein, Human (HEK293, His) is the recombinant human-derived TMED9 protein, expressed by HEK293 , with C-His labeled tag.

HY-P76679

	TMED9 Protein, Human (HEK293, Fc) transmembrane emp24 domain-containing protein 9; GMP25; p24alpha2; p25; GP25L2	Human	HEK293
	TMED9 is a key player in vesicle protein trafficking and plays an important role in the early secretory pathway, particularly in COPI vesicle-mediated retrograde transport. It promotes the recruitment of coat isoforms to the membrane, enhances ARFGAP2 activity, and ensures the specific retention of p24 complexes in cis-Golgi membranes, specifically affecting TMED2 and TMED10 localization. TMED9 Protein, Human (HEK293, Fc) is the recombinant human-derived TMED9 protein, expressed by HEK293 , with C-mFc labeled tag.

HY-P77249

	TMIGD2 Protein, Human (HEK293, Fc) transmembrane and immunoglobulin domain-containing protein 2; Immunoglobulin and proline-rich receptor 1; IGPR1; TMIGD2	Human	HEK293
	TMIGD2 is a multifaceted protein actively involved in cellular processes, including cell-cell interactions, migration, and angiogenesis. Its interaction with HHLA2 enhances T cell proliferation and cytokine production through AKT-dependent signaling during TCR-mediated activation. TMIGD2 Protein, Human (HEK293, Fc) is the recombinant human-derived TMIGD2 protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P705272

	TIGIT Protein, Mouse (Biotinylated, HEK293, Fc-Avi) T-cell immunoreceptor with Ig and ITIM domains; TIGIT; V-set and transmembrane domain-containing protein 3; VSTM3	Mouse	HEK293

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Cat. No.	Product Name	Chemical Structure

HY-15206S

Glyburide-d11

Glyburide-d₁₁ is the deuterium labeled Glibenclamide. Glibenclamide (Glyburide) is an orally active ATP-sensitive K+ channel (KATP) inhibitor and can be used for the research of diabetes and obesity . Glibenclamide inhibits P-glycoprotein. Glibenclamide directly binds and blocks the SUR1 subunits of KATP and inhibits the cystic fibrosis transmembrane conductance regulator protein (CFTR) . Glibenclamide interferes with mitochondrial bioenergetics by inducing changes on membrane ion permeability . Glibenclamide can induce autophagy .

HY-15206S1

Glyburide-d3

Glyburide-d₃ is the deuterium labeled Glibenclamide. Glibenclamide (Glyburide) is an orally active ATP-sensitive K+ channel (KATP) inhibitor and can be used for the research of diabetes and obesity[1]. Glibenclamide inhibits P-glycoprotein. Glibenclamide directly binds and blocks the SUR1 subunits of KATP and inhibits the cystic fibrosis transmembrane conductance regulator protein (CFTR)[3]. Glibenclamide interferes with mitochondrial bioenergetics by inducing changes on membrane ion permeability[4]. Glibenclamide can induce autophagy[5].

HY-15206S2

Glibenclamide-13C6

Glibenclamide- ¹³C₆ (Glyburide- ¹³C₆) is ¹³C labeled Glibenclamide. Glibenclamide (Glyburide) is an orally active ATP-sensitive K ⁺ channel (K_ATP) inhibitor and can be used for the research of diabetes and obesity . Glibenclamide inhibits P-glycoprotein. Glibenclamide directly binds and blocks the SUR1 subunits of K_ATP and inhibits the cystic fibrosis transmembrane conductance regulator protein (CFTR) . Glibenclamide interferes with mitochondrial bioenergetics by inducing changes on membrane ion permeability . Glibenclamide can induce autophagy .

HY-145603S

Vanzacaftor-d4

Vanzacaftor-d₄ (VX-121-d₄) is the deuterium labeled Vanzacaftor (HY-145603). Vanzacaftor is an orally active noval corrector of Cystic fibrosis transmembrane conductance regulator (CFTR). Vanzacaftor improves processing and trafficking of CFTR protein as well as increases chloride transport in triple combined with Tezacaftor (HY-15448) and Deutivacaftor. Vanzacaftor-Tezacaftor-Deutivacaftor is safe and well tolerated, improving lung function, respiratory symptoms, and CFTR function with cystic fibrosis, which is promising for research in the field of cystic fibrosis diseases .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P82470

	Transmembrane Protein 192 Antibody (YA2215) transmembrane protein 192	WB	Human
	Transmembrane Protein 192 Antibody (YA2215) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Transmembrane Protein 192.

HY-P82464

	Transmembrane Protein 161B Antibody (YA2209) transmembrane protein 161B	WB, IP	Human
	Transmembrane Protein 161B Antibody (YA2209) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Transmembrane Protein 161B.

HY-P86274

	Transmembrane Protein 192 Antibody (YA5966) TMEM192; transmembrane protein 192;	WB, FC	Human
	Transmembrane Protein 192 Antibody (YA5966) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Transmembrane Protein 192.

HY-P87999

	Transmembrane Protein 85 Antibody (YA7684)	WB, IHC-P, IHC-F, IF-Tissue, IP	Human

HY-P82480

	Transmembrane Protein 85 Antibody (YA2225) PIG17; TMEM85	WB, IP	Human, Mouse, Rat, Hamster
	Transmembrane Protein 85 Antibody (YA2225) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Transmembrane Protein 85.

HY-P82475

	Transmembrane Protein 30B Antibody (YA2220) CDC50B	WB	Human
	Transmembrane Protein 30B Antibody (YA2220) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Transmembrane Protein 30B.

HY-P82483

	Transmembrane Protein 9B Antibody (YA2228) C11orf15	WB	Human, Mouse, Rat
	Transmembrane Protein 9B Antibody (YA2228) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Transmembrane Protein 9B.

HY-P82478

	Transmembrane Protein 43 Antibody (YA2223) LUMA; ARVC5; ARVD5; EDMD7	WB, IHC-P	Human, Rat
	Transmembrane Protein 43 Antibody (YA2223) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Transmembrane Protein 43.

HY-P87108

	TMC1 Antibody (YA6801) transmembrane channel-like protein 1 1 publication Alternative names transmembrane cochlear-expressed protein 1 Gene names Name TMC1	WB, ICC/IF	Human, Mouse
	TMC1 Antibody (YA6801) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to TMC1.

HY-P82776

	CLPTM1 Antibody (YA2521) Cleft lip and palate transmembrane protein 1	WB, IP	Human
	CLPTM1 Antibody (YA2521) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CLPTM1.

HY-P87111

	TMP21 Antibody (YA6804) 1110014C03Rik antibody; 21 kDa transmembrane trafficking protein antibody; 21 kDa transmembrane-trafficking protein antibody; MGC102351 antibody; p23 antibody; p24 family protein delta 1 antibody; p24 family protein delta-1 antibody; p24(DELTA) antibody; p24delta antibody; p24delta1 antibody; 1110014C03Rik antibody; 21 kDa transmembrane trafficking protein antibody; 21 kDa transmembrane-trafficking protein antibody; MGC102351 antibody; p23 antibody; p24 family protein delta 1 antibody; p24 family protein delta-1 antibody; p24(DELTA) antibody; p24delta antibody; p24delta1 antibody; S31I125 antibody; S31III125 antibody; TMED 10 antibody; Tmed10 antibody; TMEDA_HUMAN antibody; Tmp 21 I antibody; Tmp 21 antibody; Tmp 21 I antibody; Tmp-21-I antibody; transmembrane emp24 domain containing protein 10 antibody; transmembrane emp24 domain-containing protein 10 antibody; transmembrane emp24-like trafficking protein 10 (yeast) antibody; transmembrane protein Tmp21 antibody; transmembrane trafficking protein 21kD antibody;	WB, IHC-P, IF-Tissue	Human, Mouse, Rat
	TMP21 Antibody (YA6804) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to TMP21.

HY-P80940

	STING Antibody 1 Publications Verification ERIS; MITA; MPYS; SAVI; NET23; STING; hMITA; hSTING; STING-beta; transmembrane protein 173	WB	Human, Mouse
	STING Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to STING.

HY-P81419

	Claudin 5 Antibody (YA1164) CLDN5; AWAL; TMVCF; Claudin-5; transmembrane protein deleted in VCFS; TMDVCF	IHC-P	Human
	Claudin 5 Antibody (YA1164) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Claudin 5.

HY-P83115

	Fragilis Antibody (YA2860) IFITM3; Interferon-induced transmembrane protein 3; Dispanin subfamily A member 2b; DSPA2b; Interferon-inducible protein 1-8U	WB, IHC-F, IHC-P, ICC/IF	Human
	Fragilis Antibody (YA2860) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Fragilis.

HY-P86615

	IFITM3 Antibody (YA6307) IFITM3; Interferon-induced transmembrane protein 3; Dispanin subfamily A member 2b; DSPA2b; Interferon-inducible protein 1-8U	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	IFITM3 Antibody (YA6307) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to IFITM3.

HY-P86617

	STING Antibody (YA6309) TMEM173; ERIS; MITA; STING; transmembrane protein 173; Endoplasmic reticulum interferon stimulator; ERIS; Mediator of IRF3 activation; hMITA; Stimulator of interferon genes protein; hSTING	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	STING Antibody (YA6309) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to STING.

HY-P81399

	CD97 Antibody (YA1144) ADGRE5; Adhesion G protein-coupled receptor E5; CD97 antigen; Leukocyte antigen CD97; Seven span transmembrane protein; TM7LN1	IHC-P	Human
	CD97 Antibody (YA1144) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CD97.

HY-P81390

	ROR2 Antibody (YA1135) NTRKR; ROR2; Tyrosine-protein kinase transmembrane receptor ROR2; Neurotrophic tyrosine kinase, receptor-related 2	IHC-P	Human
	ROR2 Antibody (YA1135) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ROR2.

HY-P87109

	TMED9 Antibody (YA6802) transmembrane emp24 domain-containing protein 9 GMP25 Glycoprotein 25L2 p24 family protein alpha-2 (p24alpha2) p25 TMED9 GP25L2	WB, IHC-P	Human, Mouse, Rat
	TMED9 Antibody (YA6802) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to TMED9.

HY-P83147

	Ephrin Receptor B4 Antibody (YA2892) EPHB4; HTK; MYK1; TYRO11; Ephrin type-B receptor 4; Hepatoma transmembrane kinase; Tyrosine-protein kinase TYRO11	WB, IHC-P	Human, Mouse, Rat
	Ephrin Receptor B4 Antibody (YA2892) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Ephrin Receptor B4.

HY-P85148

	Ephrin Receptor B4 Antibody (YA4840) EPHB4; HTK; MYK1; TYRO11; Ephrin type-B receptor 4; Hepatoma transmembrane kinase; Tyrosine-protein kinase TYRO11	WB, IHC-P, ICC/IF, ELISA	Human
	Ephrin Receptor B4 Antibody (YA4840) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Ephrin Receptor B4.

HY-P81075

	CTLA4 Antibody (YA3503) CD 152; CD152; CD152 antigen; Celiac disease 3; CELIAC3; CTLA 4; CTLA-4; Cytotoxic T cell associated 4; Cytotoxic T lymphocyte associated 4; Cytotoxic T lymphocyte associated antigen 4; Cytotoxic T lymphocyte associated protein 4; Cytotoxic T lymphocyte associated serine esterase 4; Cytotoxic T lymphocyte protein 4; Cytotoxic T-lymphocyte-associated antigen 4; Cytotoxic T-lymphocyte-associated protein 4; GSE; IDDM12; CD152 isoform; CTLA4_HUMAN; GRD4; ICOS; Ligand and transmembrane spliced cytotoxic T lymphocyte associated antigen 4.	WB, ICC/IF	Human, Mouse, Rat
	CTLA4 Antibody (YA3503) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CTLA4.

HY-P87178

	CTLA4 Antibody(YA6870) CD 152; CD152; CD152 antigen; Celiac disease 3; CELIAC3; CTLA 4; CTLA-4; Cytotoxic T cell associated 4; Cytotoxic T lymphocyte associated 4; Cytotoxic T lymphocyte associated antigen 4; Cytotoxic T lymphocyte associated protein 4; Cytotoxic T lymphocyte associated serine esterase 4; Cytotoxic T lymphocyte protein 4; Cytotoxic T-lymphocyte-associated antigen 4; Cytotoxic T-lymphocyte-associated protein 4; GSE; IDDM12; CD152 isoform; CTLA4_HUMAN; GRD4; ICOS; Ligand and transmembrane spliced cytotoxic T lymphocyte associated antigen 4.	IHC-P, mIHC	Human, Mouse
	CTLA4 Antibody(YA6870) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CTLA4.

HY-P84972

	CD184 Antibody (YA4664) CXCR4; FB22; HM89; LAP3; LCR1; NPYR; WHIM; CD184; LAP-3; LESTR; NPY3R; NPYRL; WHIMS; HSY3RR; NPYY3R; WHIMS1; D2S201E; C-X-C chemokine receptor type 4 antibody; CD184 antibody; CD184 antigen antibody; Chemokine; C X C motif; receptor 4 antibody; Chemokine CXC Motif Receptor 4 antibody; CXC-R4 antibody; CXCR-4 antibody; CXCR4 antibody; CXCR4_HUMAN antibody; D2S201E antibody; FB22 antibody; Fusin antibody; HM89 antibody; HSY3RR antibody; LAP 3 antibody; LAP3 antibody; LCR1 antibody; LESTR antibody; Leukocyte derived seven transmembrane domain receptor antibody; Leukocyte-derived seven transmembrane domain receptor antibody; Lipopolysaccharide associated protein 3 antibody; Neuropeptide Y receptor Y3 antibody; NPY3R antibody; NPYR antibody; NPYRL antibody; NPYY3 antibody; NPYY3R antibody; Probable G protein coupled receptor lcr1 homolog antibody; SDF 1 receptor antibody; SDF-1 receptor antibody; SEVEN-transmembrane-SEGMENT RECEPTOR antibody; Stromal cell derived factor 1 receptor antibody; Stromal cell-derived factor 1 receptor antibody; WHIM antibody; WHIMS antibody;
	CD184 Antibody (YA4664) is a non-conjugated antibody, targeting to CD184.

HY-P87054

	ROS1 Antibody (YA6747) c ros 1 antibody; c ros antibody; c ros oncogene 1 receptor tyrosine kinase antibody; c Ros receptor tyrosine kinase antibody; c ros1 antibody; MCF 3 antibody; MCF3 antibody; Oncogene ROS antibody; OTTHUMP00000017814 antibody; OTTHUMP00000017815 antibody; c ros 1 antibody; c ros antibody; c ros oncogene 1 receptor tyrosine kinase antibody; c Ros receptor tyrosine kinase antibody; c ros1 antibody; MCF 3 antibody; MCF3 antibody; Oncogene ROS antibody; OTTHUMP00000017814 antibody; OTTHUMP00000017815 antibody; OTTHUMP00000040389 antibody; Proto oncogene c ros 1 protein antibody; Proto oncogene c Ros antibody; Proto oncogene tyrosine protein kinase ROS antibody; Proto oncogene tyrosine protein kinase ROS precursor antibody; Proto-oncogene c-Ros-1 antibody; Proto-oncogene tyrosine-protein kinase ROS antibody; Receptor tyrosine kinase c ros oncogene 1 antibody; Ros 1 antibody; ROS 1C antibody; ROS antibody; ROS proto oncogene 1 , receptor tyrosine kinase antibody; ROS_HUMAN antibody; ROS1 antibody; ROS1C antibody; transmembrane tyrosine specific protein kinase antibody; v ros avian UR2 sarcoma virus oncogene homolog 1 antibody; v ros UR2 sarcoma virus oncogene homolog 1 antibody;	IHC-P	Human
	ROS1 Antibody (YA6747) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ROS1.

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Cat. No.	Product Name		Classification

HY-148033

Trimethyl chitosan N,N,N-Trimethylchitosan		Polymers
Trimethyl chitosan (N,N,N-Trimethylchitosan) is a multifunctional polymer and a derivative of Chitosan (HY-B2144A). Trimethyl chitosan targets the absorption enhancing proteins of tight junctions of intestinal and mucosal epithelial cells, induces tight junction protein rearrangement, and increases intercellular permeability. Trimethyl chitosan can stimulate the activity of promoting transmembrane transport of hydrophilic drugs (such as peptides and proteins) and can be used for drug delivery and synthesis of nanoparticles .

HY-153084A

CD19 CAR mRNA (Human) 1 Publications Verification		mRNA
CD19 CAR mRNA (Human) expresses Human CD19 CAR protein. CD19 CAR mRNA can trigger transitory expression of CAR, allowing T cells to be targeted without permanent genetic modification. CD19 CAR mRNA targets CD19 which is a transmembrane glycoprotein primarily expressed on B lymphocytes and is important in B cell activation. CD19 CAR mRNA can be studied in cancer research such as lymphoma and leukemia .

HY-174640

Human IL12RB1 mRNA		mRNA
Human IL12RB1 mRNA encodes the human interleukin 12 receptor subunit beta 1 (IL12RB1) protein, a type I transmembrane protein that belongs to the hemopoietin receptor superfamily.

HY-174612

Human IL27RA mRNA		mRNA
Human IL27RA mRNA encodes the human interleukin 27 receptor subunit alpha (IL27RA) protein, a protein that is similar to the mouse T-cell cytokine receptor (Tccr) at the amino acid level. IL27RA is predicted to be a glycosylated transmembrane protein.

HY-174774

Human BMPR1B mRNA		mRNA
Human BMPR1B mRNA encodes the human bone morphogenetic protein receptor type 1B (BMPR1B) protein, a family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis.

HY-174775

Human BMPR1A mRNA		mRNA
Human BMPR1A mRNA encodes the human bone morphogenetic protein receptor type 1A (BMPR1A) protein, a family of transmembrane serine/threonine kinases. BMPR1A may play a role in positively regulating chondrocyte differentiation through GDF5 interaction and mediating induction of adipogenesis by GDF6.

HY-174603

Human IL4R mRNA		mRNA
Human IL4R mRNA encodes the human interleukin 4 receptor (IL4R) protein, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. IL4R also can bind interleukin 4 to promote differentiation of Th2 cells.

HY-174530

Human TGFBR2 mRNA		mRNA
Human TGFBR2 mRNA encodes the human transforming growth factor beta receptor 2 (TGFBR2) protein, a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with TGF-beta receptor type-1, and binds TGF-beta. TGFBR2/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of genes related to cell proliferation, cell cycle arrest, wound healing, immunosuppression, and tumorigenesis.

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