EphB4 Antibody (YA4840)

EphB4 Antibody (YA4840) is a mouse-derived and non-conjugated monoclonal antibody, targeting to EphB4. It can be applicated for WB, IHC-P, ICC/IF, ELISA assays, in the background of human.

EphB4 protein, a receptor tyrosine kinase, engages in promiscuous binding to transmembrane ephrin-B family ligands located on adjacent cells, initiating contact-dependent bidirectional signaling. The downstream pathway originating from the receptor is termed forward signaling, while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Collaborating with its cognate ligand, EFNB2, EphB4 is intricately involved in regulating cell adhesion and migration. Moreover, EphB4 assumes a central role in heart morphogenesis, angiogenesis, and the remodeling and permeability of blood vessels. The forward signaling mediated by EPHB4 is instrumental in controlling cellular repulsion and segregation from EFNB2-expressing cells.

P54760

Predicted band size: 108 kDa;

affinity purified.

Non-conjugated

Unmodified

Primary Antibody; Mouse Monoclonal Antibody

Monoclonal

Mouse

Human

WB: 1:500-1:2000; IHC: 1:200-1:1000; ELISA: 1:10000; ICC/IF: 1:50-200

WB, IHC-P, ICC/IF, ELISA

Liquid

Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

Purified recombinant fragment of EphB4 expressed in E. Coli.