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Camp

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (15) Acyltransferase (1) Adenosine Receptor (25) Adenylate Cyclase (11) Adhesion G Protein-coupled Receptors (AGPCRs) (1) Adrenergic Receptor (23) Akt (5) Aminotransferases (Transaminases) (1) AMPK (2) Amyloid-β (2) Antibiotic (10) Apelin Receptor (APJ) (9) Apoptosis (27) Arrestin (12) Autophagy (6) Bacterial (20) Biochemical Assay Reagents (10) Bradykinin Receptor (1) Calcium Channel (9) Calmodulin (2) CaMK (1) Cannabinoid Receptor (10) Casein Kinase (1) Caspase (15) CCR (1) CDK (1) CFTR (7) CGRP Receptor (9) Chloride Channel (3) Cholinesterase (ChE) (2) CRFR (5) CXCR (6) Dopamine Receptor (17) Drug Derivative (1) Drug Intermediate (1) Drug Isomer (1) Drug Metabolite (2) EGFR (5) Elastase (1) Endogenous Metabolite (35) Endothelin Receptor (1) Epigenetic Reader Domain (6) ERK (7) Estrogen Receptor/ERR (3) Ferroptosis (1) Flavivirus (2) Fluorescent Dye (5) Free Fatty Acid Receptor (2) Fungal (1) FXR (4) G protein-coupled Bile Acid Receptor 1 (2) GABA Receptor (3) GCGR (9) Gli (1) GLP Receptor (10) Glutathione Peroxidase (3) Glycosidase (2) GPR119 (2) GPR139 (1) GPR52 (1) GPR65 (2) GPR84 (3) GPR88 (6) GSK-3 (1) HDAC (4) Histamine Receptor (9) Histone Acetyltransferase (1) HIV (2) iGluR (1) Indoleamine 2,3-Dioxygenase (IDO) (1) Influenza Virus (1) Insecticide (1) Insulin Receptor (2) Interleukin Related (4) Isotope-Labeled Compounds (26) JNK (2) Kisspeptin Receptor (2) Lipoxygenase (1) LPL Receptor (1) mAChR (1) Melanocortin Receptor (5) mGluR (10) Microtubule/Tubulin (1) Mineralocorticoid Receptor (1) MMP (1) Monoamine Oxidase (3) mTOR (2) Myosin (3) Neprilysin (1) Neuromedin U Receptor (NMUR) (1) Neuropeptide FF Receptor (1) Neuropeptide S Receptor (1) Neuropeptide Y Receptor (4) NF-κB (4) NO Synthase (5) Nuclear Factor of activated T Cells (NFAT) (1) Nucleoside Antimetabolite/Analog (16) Opioid Receptor (6) Organoid (2) Orphan Receptor (1) P2Y Receptor (1) p38 MAPK (2) PACAP Receptor (6) Parasite (4) PEPCK (1) PERK (2) Phosphodiesterase (PDE) (87) PKA (78) PKC (16) PKG (2) Potassium Channel (2) PPAR (4) Prostaglandin Receptor (18) Protein Arginine Deiminase (3) PTEN (2) PTHR (2) Ras (14) Reactive Oxygen Species (ROS) (4) Reference Standards (38) ROCK (3) RXFP Receptor (10) Salt-inducible Kinase (SIK) (2) Serpin (1) Small Interfering RNA (siRNA) (8) SOD (7) Sodium Channel (1) Somatostatin Receptor (6) SphK (1) STING (6) Succinate Receptor 1 (1) Thyroid Hormone Receptor (2) TNF Receptor (6) TSH Receptor (1) Tyrosinase (4) Vasopressin Receptor (1)
By Research Areas:	Cancer (109) Cardiovascular Disease (95) Endocrinology (69) Infection (33) Inflammation/Immunology (120) Metabolic Disease (110) Neurological Disease (160)
Click Chemistry:	Azide (1)
Oligonucleotides:	Antioxidants (1) A (2) Nucleosides and their Analogs (2) Rat Pre-designed siRNA Sets (2) Mouse Pre-designed siRNA Sets (2) Human Pre-designed siRNA Sets (4) Antisense Oligonucleotides (2) Chelating Agents (1) siRNAs (8)

533

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B1511

Cyclic AMP 10+ Cited Publications Cyclic adenosine monophosphate; Adenosine cyclic 3', 5'-monophosphate; Camp	Endogenous Metabolite	Neurological Disease Metabolic Disease Cancer
Cyclic AMP (Cyclic adenosine monophosphate), adenosine triphosphate derivative, is an intracellular signaling molecule responsible for directing cellular responses to extracellular signals. Cyclic AMP is an important second messenger in many biological processes .

HY-B1511A

Cyclic AMP sodium 10+ Cited Publications Cyclic adenosine monophosphate sodium; Adenosine cyclic 3', 5'-monophosphate sodium; Camp sodium; Cyclic AMP sodium	Biochemical Assay Reagents	Neurological Disease Metabolic Disease Cancer
Cyclic AMP (Cyclic adenosine monophosphate) sodium, adenosine triphosphate derivative, is an intracellular signaling molecule responsible for directing cellular responses to extracellular signals. Cyclic AMP sodium is an important second messenger in many biological processes .

HY-B1511R

Cyclic AMP (Standard) Cyclic adenosine monophosphate (Standard); Adenosine cyclic 3', 5'-monophosphate (Standard); Camp (Standard)	Endogenous Metabolite Reference Standards	Cancer
Cyclic AMP (Standard) is the analytical standard of Cyclic AMP. Cyclic AMP (Cyclic adenosine monophosphate), adenosine triphosphate derivative, is an intracellular signaling molecule responsible for directing cellular responses to extracellular signals. Cyclic AMP is an important second messenger in many biological processes .

HY-RS22909

Vamp5 Mouse Pre-designed siRNA Set A Camp	Small Interfering RNA (siRNA)	Others
Vamp5 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Vamp5 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Vamp5 Mouse Pre-designed siRNA Set A Vamp5 Mouse Pre-designed siRNA Set A

HY-RS02596

CHAMP1 Human Pre-designed siRNA Set A Camp; CHAMP; MRD40; ZNF828; C13orf8; NEDHILD	Small Interfering RNA (siRNA)	Others
CHAMP1 Human Pre-designed siRNA Set A contains three designed siRNAs for CHAMP1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

CHAMP1 Human Pre-designed siRNA Set A CHAMP1 Human Pre-designed siRNA Set A

HY-RS23258

Camp Rat Pre-designed siRNA Set A CRAMP	Small Interfering RNA (siRNA)	Others
Camp Rat Pre-designed siRNA Set A contains three designed siRNAs for Camp gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Camp Rat Pre-designed siRNA Set A Camp Rat Pre-designed siRNA Set A

HY-RS16241

Camp Mouse Pre-designed siRNA Set A CLP; Cnlp; MCLP; CAP18; Cramp; FALL39	Small Interfering RNA (siRNA)	Others
Camp Mouse Pre-designed siRNA Set A contains three designed siRNAs for Camp gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Camp Mouse Pre-designed siRNA Set A Camp Mouse Pre-designed siRNA Set A

HY-RS01870

CAMP Human Pre-designed siRNA Set A LL37; CAP18; CRAMP; HSD26; CAP-18; FALL39; FALL-39	Small Interfering RNA (siRNA)	Others
CAMP Human Pre-designed siRNA Set A contains three designed siRNAs for CAMP gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

CAMP Human Pre-designed siRNA Set A CAMP Human Pre-designed siRNA Set A

HY-RS27769

Rapgef4 Rat Pre-designed siRNA Set A Camp-GEFII; CampS; Cgef2; Epac2	Small Interfering RNA (siRNA)	Others
Rapgef4 Rat Pre-designed siRNA Set A contains three designed siRNAs for Rapgef4 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Rapgef4 Rat Pre-designed siRNA Set A Rapgef4 Rat Pre-designed siRNA Set A

HY-RS11662

RAPGEF3 Human Pre-designed siRNA Set A EPAC; EPAC1; bcm910; HSU79275; Camp-GEFI	Small Interfering RNA (siRNA)	Others
RAPGEF3 Human Pre-designed siRNA Set A contains three designed siRNAs for RAPGEF3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

RAPGEF3 Human Pre-designed siRNA Set A RAPGEF3 Human Pre-designed siRNA Set A

HY-RS11663

RAPGEF4 Human Pre-designed siRNA Set A EPAC; CGEF2; EPAC2; EPAC 2; Nbla00496; Camp-GEFII	Small Interfering RNA (siRNA)	Others
RAPGEF4 Human Pre-designed siRNA Set A contains three designed siRNAs for RAPGEF4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

RAPGEF4 Human Pre-designed siRNA Set A RAPGEF4 Human Pre-designed siRNA Set A

HY-B1511S

Cyclic AMP-13C5 Cyclic adenosine monophosphate-¹³C₅; Adenosine cyclic 3', 5'-monophosphate-¹³C₅; Camp-¹³C₅	Isotope-Labeled Compounds	Others
Cyclic AMP- ¹³C₅ is a deuterated cyclic AMP.

HY-131768

2'-O-Succinyl-cAMP	Cholinesterase (ChE)	Others
2'-O-Succinyl-cAMP is a cAMP analog that can be covalently coupled to acetylcholinesterase. 2'-O-Succinyl-cAMP conjugate has been used as tracers in a classical heterogeneous competitive enzyme immunoassay allowing the determination of cAMP .

HY-134254

8-AHA-cAMP 8-(6-Aminohexylamino)-Camp	Biochemical Assay Reagents	Others
8-AHA-cAMP (8-(6-Aminohexylamino)-cAMP) is a cAMP derivative that modulates the function of proteins by interacting with their cAMP binding domain (CNBD). 8-AHA-cAMP can be used to reveal the mechanism of action of cAMP in cell signaling .

HY-134299

*8-CPT-cAMP-AM* 8-(4-Chlorophenylthio)-Camp-AM	Ras	Others
8-CPT-cAMP-AM is a highly membrane-permeant analogue of signal molecule cAMP. 8-CPT-cAMP-AM is an activator of cAMP- and cGMP-dependent protein kinases and of Epac (exchange protein activated by cAMP) .

HY-137628

Sp-8-PIP cAMP	PKA	Cancer
Sp-8-PIP cAMP sodium is a non-corresponding isomer of 8-Piperidino-cAMP. 8-Piperidino-cAMP binds with high affinity to site A of the regulatory subunit of cAMP-dependent protein kinase type I (AI). Sp-8-PIP cAMP sodium can be used as an antagonist of cAMP-induced activation .

HY-123396

8-Chloro-cAMP	PKA	Cancer
8-Chloro-cAMP is a cAMP analogue that induces growth arrest, and modulates cAMP-dependent PKA activity. 8-Chloro-cAMP has anticancer activity .

HY-123396A

*8-Chloro-cAMP* sodium**	PKA	Cancer
8-Chloro-cAMP sodium is a cAMP analogue that induces growth arrest, and modulates cAMP-dependent PKA activity. 8-Chloro-cAMP sodium has anticancer activity .

HY-134340

8-pMeOPT-2'-O-Me-cAMP 8-(4-Methoxyphenylthio)-2'-O-Me-Camp	Ras	Others
8-pMeOPT-2'-O-Me-cAMP is an analogue of the signal molecule cAMP and a potent stimulator of exchange factors activated by cAMP (Epac), while it doesn't activate PKA as cAMP does .

HY-137530

8-MA-cAMP 8-Methylamino-Camp	PKA	Others
8-MA-cAMP (8-Methylamino-cAMP) is a cyclic AMP analog that acts as a site-selective PKA agonist with similar affinity for the B site of type I and type II protein kinase A. 8-MA-cAMP is used in conjunction with priming analogs that show site A preference, such as 8-piperidinyl cAMP, to achieve selective stimulation of type I .

HY-137381

6-Bnz-cAMP N6-Benzoyl-Camp	Potassium Channel	Others
6-Bnz-cAMP (N6-Benzoyl-cAMP), a derivative of cyclic adenosine monophosphate (cAMP), is a potent inhibitor of the bTREK-1 potassium channel. 6-Bnz-cAMP can strongly inhibit the bTREK-1 potassium channel through a protein kinase A (PKA) independent mechanism. 6-Bnz-cAMP can be used to explore potential signal transduction proteins in the cAMP signaling pathway .

HY-134321

8-Azido-cAMP	Fluorescent Dye	Others
8-Azido-cAMP is a fluorescent cAMP analog, acting as the model target of detecting cAMP . 8-Azido-cAMP is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-131777

2-Cl-cAMP	PKA	Others
2-Cl-cAMP is an analog of cAMP and a potent stimulator of cAMP-dependent protein kinases such as PKA type I and II. 2-Cl-cAMP can be used as starting material for cyclic nucleotides .

HY-134325

8-OH-cAMP 8-Hydroxy-Camp	PKA	Cardiovascular Disease Metabolic Disease
8-OH-cAMP (8-Hydroxy-cAMP) is a polar, membrane-impermeable cyclic adenosine monophosphate analog that is resistant to mammalian cyclic nucleotide-dependent phosphodiesterases. As a polar PKA agonist, 8-OH-cAMP is used to study the role of cAMP in the development and progression of cardiovascular and metabolic diseases .

HY-134302

8-HA-cAMP 8-Hexylamino-Camp	PKA	Others
8-HA-cAMP is a membrane-permeable cAMP analogue and an activator of cAMP-dependent protein kinase and PKA I. 8-HA-cAMP exerts metabolic stability towards mammalian cyclic nucleotide-responsive phosphodiesterases .

HY-134348

8-pHPT-2'-O-Me-cAMP 8-(4-Hydroxyphenylthio)-2'-O-Me-Camp	Ras	Cardiovascular Disease
8-pHPT-2'-O-Me-cAMP is a cAMP analog and an Epac agonist. 8-pHPT-2'-O-Me-cAMP can be used in cardiac research .

HY-134308

*8-NBD-cAMP* sodium**	Fluorescent Dye	Others
8-NBD-cAMP sodium is a fluorescently labeled cyclic adenosine phosphate (cAMP) analogue. 8-NBD-cAMP sodium retains a similar biological activity to cAMP, regulating their activity by binding to specific proteins such as EPACs or PKA. 8-NBD-cAMP sodium can be used in fluorescent competitive binding experiments to evaluate the binding affinity of newly synthesized EPAC1 agonists to EPAC1 proteins .

HY-134298

8-CPT-6-Phe-cAMP 8-(4-Chlorophenylthio)-N6-phenyl-Camp	PKA	Others
8-CPT-6-Phe-cAMP is an analogue of signal molecule cAMP and a potent protein kinase A (PKA) activator .

HY-134264

8-Br-2'-O-Me-cAMP	Ras	Cardiovascular Disease Neurological Disease
8-Br-2'-O-Me-cAMP is an analogue of the signal molecule cyclic AMP (cAMP). 8-Br-2'-O-Me-cAMP is an agonist of exchange factors activated by cAMP (Epac), while it doesn't activate PKA as cAMP do. 8-Br-2'-O-Me-cAMP can be used in cardiovascular disease research .

HY-131772

2-AHA-cAMP	Fluorescent Dye	Others
2-AHA-cAMP is an analogue of natural signal molecule cAMP and an activator of cAMP-dependent protein kinase. 2-AHA-cAMP has a free terminal primary amino group, which can be used for coupling to gels or fluorescent dyes .

HY-134283

8-Benzylthio-cAMP	PKA Apoptosis	Others
8-Benzylthio-cAMP is a derivative of cyclic adenosine monophosphate (cAMP). 8-Bn-cAMP is a site-selective activator of cAMP-dependent protein kinases. Compared with cyclic adenosine monophosphate, it is more stable to phosphodiesterase (PDE) hydrolysis and has higher membrane permeability. 8-Bn-cAMP can be used to study the role of cAMP in regulating cell proliferation, differentiation and apoptosis .

HY-134263

*8-Br-cAMP-AM*	PKA Ras	Cardiovascular Disease
8-Br-cAMP-AM is a cyclic adenosine monophosphate (cAMP) analog that activates two major signal transduction pathways in the heart by mimicking the effects of cAMP: protein kinase A (PKA) and guanosine nucleotide exchange factor (Epac), which is directly activated by cAMP. 8-Br-cAMP-AM can be used to study cardiac ischemia and reperfusion injury .

HY-B0764

Bucladesine sodium 30+ Cited Publications Dibutyryl Camp sodium salt; DBCamp sodium salt	PKA Phosphodiesterase (PDE)	Inflammation/Immunology
Bucladesine sodium salt (Dibutyryl-cAMP sodium salt) is a stabilized cyclic AMP (cAMP) analog and a selective PKA activator. Bucladesine sodium salt raises the intracellular levels of cAMP. Bucladesine sodium salt is also a phosphodiesterase (PDE) inhibitor. Bucladesine sodium salt has anti-inflammatory activity and can be used for impaired wound healing .

HY-131842

6-Bn-cAMP N6-Benzyladenosine-3',5'-cyclic monophosphate	PKA	Cancer
6-Bn-cAMP is a site-selective activator of cAMP-dependent protein kinase (PKA) which does not activate Epac. 6-Bn-cAMP increases hydrolytic stability against PDE, esterases, amidases and considerably higher membrane permeability compared to cAMP .

HY-131766

2'-O-Me-cAMP 2'-O-Methyladenosine-3',5'-cyclic monophosphate	Ras	Others
2'-O-Me-cAMP is an analogue of natural signal molecule cAMP and a selective stimulator of the exchange factors activated by cAMP (Epac) with low membrane permeability .

HY-134395

6-MB-cAMP N6-Monobutyryl-Camp	Biochemical Assay Reagents	Others
6-MB-cAMP is a cAMP agonist. 6-MB-cAMP is a membrane permeable analog of cAMP .

HY-B0764R

Bucladesine sodium (Standard) Dibutyryl Camp sodium salt (Standard); DBCamp sodium salt (Standard)	Reference Standards PKA Phosphodiesterase (PDE)	Inflammation/Immunology
Bucladesine (sodium) (Standard) is the analytical standard of Bucladesine (sodium). This product is intended for research and analytical applications. Bucladesine sodium salt (Dibutyryl-cAMP sodium salt) is a stabilized cyclic AMP (cAMP) analog and a selective PKA activator. Bucladesine sodium salt raises the intracellular levels of cAMP. Bucladesine sodium salt is also a phosphodiesterase (PDE) inhibitor. Bucladesine sodium salt has anti-inflammatory activity and can be used for impaired wound healing .

HY-B0764B

Bucladesine Dibutyryl Camp; DBCamp	PKA	Neurological Disease
Bucladesine (DBcAMP) is a membrane permeable selective activator that activates cyclic adenosine phosphate dependent protein kinase A (PKA). The main regulatory mechanism of Bucladesine involves the cAMP/PKA signaling pathway. When Bucladesine activates PKA, it can promote a variety of cellular processes, including neurodevelopment, growth and plasticity. In particular, the cAMP/PKA signaling pathway plays a key role in the expression of long-term enhancement (LTP) and long-term inhibition (LTD), as well as in the formation of long-term memory in the hippocampus. Bucladesine can be used to study memory formation and neuroplasticity .

HY-12306

*8-Bromo-cAMP* sodium salt** 20+ Cited Publications 8-Br-Camp sodium salt	PKA Apoptosis	Cancer
8-Bromo-cAMP sodium (8-Br-Camp) sodium salt, a cyclic AMP analog, is an activator of cyclic AMP-dependent protein kinase (PKA). 8-Bromo-cAMP sodium salt has anti-proliferative and apoptotic effects against cancer cells .

HY-12306A

8-Bromo-cAMP 20+ Cited Publications 8-Br-Camp	PKA Apoptosis	Cancer
8-Bromo-cAMP (8-Br-Camp), a cyclic AMP analog, is an activator of cyclic AMP-dependent protein kinase (PKA). 8-Bromo-cAMP has anti-proliferative and apoptotic effects against cancer cells .

HY-103322

*6-Bnz-cAMP* sodium salt**	PKA	Cancer
6-Bnz-cAMP sodium salt is a cell-permeable cAMP analog. 6-Bnz-cAMP selectively activates cAMP-dependent PKA but not Epac signaling pathways .

HY-107543

*8-pCPT-2′-O-Me-cAMP* sodium** 1 Publications Verification 8-CPT-2'-O-Me-Camp sodium	Ras	Cardiovascular Disease
8-pCPT-2′-O-Me-cAMP (8-CPT-2'-O-Me-cAMP) sodium, an analog of cAMP, is an activator of *exchange proteins activated by cAMP* (Epac)*. 8-pCPT-2′-O-Me-cAMP* sodium activates Epac1 (EC₅₀ = 2.2 μM), but not PKA (EC₅₀ >10 μM). 8-pCPT-2′-O-Me-cAMP sodium stimulates Epac-mediated Ca ²⁺ release in pancreatic β-cells in vitro. 8-pCPT-2′-O-Me-cAMP sodium is a Rap1 activator. 8-pCPT-2′-O-Me-cAMP sodium enhances the retinal pigment epithelium barrier against the pathological choroidal endothelial cell invasion that occurs in macular degeneration .

HY-116312

8-pCPT-2′-O-Me-cAMP 8-CPT-2'-O-Me-Camp	Ras	Cardiovascular Disease
8-pCPT-2′-O-Me-cAMP (8-CPT-2'-O-Me-cAMP), an analog of cAMP, is an activator of *exchange proteins activated by cAMP* (Epac)*. 8-pCPT-2′-O-Me-cAMP* activates Epac1 (EC₅₀ = 2.2 μM), but not PKA (EC₅₀ >10 μM). 8-pCPT-2′-O-Me-cAMP stimulates Epac-mediated Ca ²⁺ release in pancreatic β-cells in vitro. 8-pCPT-2′-O-Me-cAMP is a Rap1 activator. 8-pCPT-2′-O-Me-cAMP enhances the retinal pigment epithelium barrier against the pathological choroidal endothelial cell invasion that occurs in macular degeneration .

HY-171021

8-Nitro-2'3'cAMP	Nucleoside Antimetabolite/Analog	Others
8-Nitro-2'3'cAMP is composed of 8-nitro-AMP, ribose and phosphate, and is a cyclic nucleotide derivative .

HY-B0764A

Bucladesine calcium 30+ Cited Publications Dibutyryl Camp calcium salt; DBCamp calcium salt	PKA Phosphodiesterase (PDE) Apoptosis	Others
Bucladesine calcium salt (Dibutyryl-cAMP calcium salt;DC2797 calcium salt) is a cell-permeable cyclic AMP (cAMP) analog and selectively activates cAMP dependent protein kinase (PKA) by increasing the intracellular level of cAMP. Bucladesine calcium salt acts as a phosphodiesterase (PDE) inhibitor.

HY-131421

8-PIP-cAMP 8-Piperidino-cyclic AMP	PKA	Cancer
8-PIP-cAMP is a selective cAMP-dependent protein kinase activator and can be used for study of cancer .

HY-107544

*8-pCPT-2'-O-Me-cAMP-AM*	PKA	Metabolic Disease
8-pCPT-2'-O-Me-cAMP-AM is a cyclic AMP analogue, selectively activates Epac-Rap signaling pathway. 8-pCPT-2'-O-Me-cAMP-AM protects renal function by activating Epac from ischemia injury. 8-pCPT-2'-O-Me-cAMP-AM also stimulates insulin secretion by interaction with PKA pathway .

HY-134389

6-Phe-cAMP N6-Phenyladenosine-3',5'-cyclic monophosphate	PKA	Cancer
6-Phe-cAMP is a site-selective and highly membrane-permeant activator of protein kinase A (PKA), with a strong preference for site A of both isozymes. 6-Phe-cAMP can undergo phosphorothioate modification .

HY-131763

*2'-O-MB-cAMP* sodium** 2'-O-Monobutyryl cyclic AMP sodium	Drug Intermediate	Others
2'-O-MB-cAMP (2'-O-Monobutyryl cyclic AM) sodium is an activatable proagent of Cyclic AMP (HY-B1511) .

HY-120994A

Rp-8-CPT-cAMPS	PKA	Neurological Disease Inflammation/Immunology
Rp-8-CPT-cAMPS, a cAMP analog, is a potent and competitive antagonist of cAMP-induced activation of cAMP-dependent PKA I and II. Rp-8-CPT-cAMPS preferentially selects site A of RI compares to site A of RII and site B of RII compares to site B of RI .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B1511

Cyclic AMP 10+ Cited Publications Cyclic adenosine monophosphate; Adenosine cyclic 3', 5'-monophosphate; Camp	Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Cyclic AMP (Cyclic adenosine monophosphate), adenosine triphosphate derivative, is an intracellular signaling molecule responsible for directing cellular responses to extracellular signals. Cyclic AMP is an important second messenger in many biological processes .

HY-124151

Adenosine-2'-monophosphate 2'-AMP; Adenosine 2'-phosphate; AMP 2'-phosphate	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Adenosine Receptor Endogenous Metabolite
Adenosine-2'-monophosphate (2'-AMP) is converted by extracellular 2’,3'-CAMP. Adenosine-2'-monophosphate is further metabolized to extracellular adenosine (a mechanism called the extracellular 2’,3’-cAMP-adenosine pathway). Adenosine-2'-monophosphate inhibits LPS-induced TNF-α and CXCL10 production via A_2A receptor activation .

HY-15371

Forskolin Maximum Cited Publications 136 Publications Verification Coleonol; Colforsin; HL 362	Structural Classification Classification of Application Fields Terpenoids Labiatae Source classification Metabolic Disease Diterpenoids Plants Inflammation/Immunology Disease Research Fields Endocrinology Pueraria montana (Lour.) Merr.	Organoid Adenylate Cyclase FXR Autophagy PKC
Forskolin (Coleonol) is a potent adenylate cyclase activator with an IC₅₀ of 41 nM and an EC₅₀ of 0.5 μM for type I adenylyl cyclase . Forskolin is also an inducer of intracellular *cAMP* formation . Forskolin induces differentiation of various cell types and activates pregnane X receptor (PXR) and FXR . Forskolin exerts a inotropic effect on the heart, and has platelet antiaggregatory and antihypertensive actions. Forskolin also induces autophagy .

HY-N0113

Hordenine 1 Publications Verification Ordenina; Peyocactine	Cardiovascular Disease Alkaloids Structural Classification Monophenols other families Classification of Application Fields Other Alkaloids Source classification Phenols Plants Disease Research Fields	Bacterial Antibiotic
Hordenine, an alkaloid found in plants, inhibits melanogenesis by suppression of cyclic adenosine monophosphate (cAMP) production .

HY-N0113B

Hordenine hydrochloride 1 Publications Verification Ordenina hydrochloride; Peyocactine hydrochloride	Coryphantha vivipara var arizonica Structural Classification Alkaloids Monophenols Cactaceae Other Alkaloids Source classification Phenols Plants	Antibiotic
Hordenine (hydrochloride), an alkaloid found in plants, inhibits melanogenesis by suppression of cyclic adenosine monophosphate (cAMP) production .

HY-N1189

DL-Syringaresinol diacetate Syringaresinol Diacetate	Structural Classification Natural Products Source classification Plants Menispermaceae	Others
DL-Syringaresinol diacetate is a glucoside. DL-Syringaresinol inhibits cAMP phosphodiesterase and alleviation of stress .

HY-N3550

Catalponol	Other Terpenoids Structural Classification Catalpa ovata G. Don Classification of Application Fields Terpenoids Source classification Bignoniaceae Plants Disease Research Fields Cancer	Others
Catalponol is a naphthoquinone derivative. Catalponol enhances dopamine biosynthesis by inducing tyrosine hydroxylase activity. Catalponol also increases the levels of cAMP and tyrosine hydroxylase phosphorylation in PC12 cells .

HY-N2658

5,7-Diacetoxy-8-methoxyflavone	Flavones Labiatae Source classification Plants Medicago truncatula Gaertn.	Phosphodiesterase (PDE)
5,7-Diacetoxy-8-methoxyflavone is a natural product that could come from scutellaria genus plants. 5,7-Diacetoxy-8-methoxyflavone has inhibitory activity for cAMP phosphodiesterase .

HY-15371R

Forskolin (Standard) Coleonol (Standard); Colforsin (Standard); HL 362 (Standard)	Structural Classification Terpenoids Labiatae Source classification Diterpenoids Plants Pueraria montana (Lour.) Merr.	Organoid Reference Standards Adenylate Cyclase FXR Autophagy PKC
Forskolin (Standard) is the analytical standard of Forskolin. This product is intended for research and analytical applications. Forskolin (Coleonol) is a potent adenylate cyclase activator with an IC₅₀ of 41 nM and an EC₅₀ of 0.5 μM for type I adenylyl cyclase . Forskolin is also an inducer of intracellular cAMP formation . Forskolin induces differentiation of various cell types and activates pregnane X receptor (PXR) and FXR . Forskolin exerts a inotropic effect on the heart, and has platelet antiaggregatory and antihypertensive actions. Forskolin also induces autophagy .

HY-126754

Archangelicin	Structural Classification Source classification Pseudodictamnus aucheri (Boiss.) Salmaki & Siadati Coumarins Phenylpropanoids Umbelliferae Plants	Nuclear Factor of activated T Cells (NFAT) Phosphodiesterase (PDE)
Archangelicin is an inhibitor for cAMP-phosphodiesterase (cAMP-PDE) with IC₅₀ >400 μM. Archangelicin inhibits nuclear factor of activated T cell (NFAT) with IC₅₀ of 9 μM. Archangelicin exhibits antitumor and anti-inflammatory .

HY-N13132

Hellicoside	Plantaginaceae Structural Classification Source classification Phenols Polyphenols Plantago asiatica L. Plants	Phosphodiesterase (PDE) Lipoxygenase
Hellicoside is a natural product that can be obtained from plantain. Hellicoside has inhibitory activity against cAMP phosphodiesterase and 5-lipoxygenase .

HY-N3324

Mangostanol (+)-Mangostanol	Structural Classification Flavonoids Source classification Guttiferae Plants Garcinia hanburyi Hook. f. Other Flavonoids	Phosphodiesterase (PDE)
Mangostanol ((+)-Mangostanol) is a polyoxygenated xanthone mangostanol, which can be isolated from the shell of Garcinia mangostana, and has inhibitory effect on cAMP phosphodiesterase (PDE) .

HY-124371

Amentoflavone hexaacetate	Structural Classification Flavonoids Viburnaceae Source classification Plants Biflavones Viburnum lantana L.	Phosphodiesterase (PDE)
Amentoflavone hexaacetate is a 3,5-cyclic nucleotide phosphodiesterase inhibitor with antiplatelet aggregation activity. Amentoflavone hexaacetate can inhibit the aggregation of eluted human platelets induced by ADP or collagen. Amentoflavone hexaacetate can also inhibit the cAMP phosphodiesterase activity in human platelets. Amentoflavone hexaacetate can significantly increase the cAMP level of platelets in the presence of prostaglandin E1. Amentoflavone hexaacetate has anti-angiogenic and anti-metastatic effects .

HY-111896

7-Methoxyrosmanol 7-O-Methoxyrosmanol	Structural Classification other families Classification of Application Fields Terpenoids Source classification Other Diseases Phenols Polyphenols Diterpenoids Plants Disease Research Fields	PEPCK
7-Methoxyrosmanol (7-O-Methoxyrosmanol), a phenolic diterpene isolated from rosemary, suppresses the cAMP responsiveness of PEPCK and G6Pase promoters .

HY-N14662

Griseolic acid B 7′-Desoxygriseolic acid	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source classification	Phosphodiesterase (PDE)
Griseolic acid B (7′-Desoxygriseolic acid) has the activity of inhibiting *cyclic adenosine monophosphate (cAMP) phosphodiesterase* [EC 3.1.4.17] with an IC₅₀ of 0.16 μM .

HY-N0113R

Hordenine (Standard) Ordenina (Standard); Peyocactine (Standard)	Cardiovascular Disease Structural Classification Alkaloids other families Classification of Application Fields Source classification Phenols Plants Disease Research Fields	Reference Standards Bacterial Antibiotic
Hordenine (Standard) is the analytical standard of Hordenine. This product is intended for research and analytical applications. Hordenine, an alkaloid found in plants, inhibits melanogenesis by suppression of cyclic adenosine monophosphate (cAMP) production .

HY-N0113BR

Hordenine hydrochloride (Standard) Ordenina hydrochloride (Standard); Peyocactine hydrochloride (Standard)	Coryphantha vivipara var arizonica Structural Classification Alkaloids Monophenols Cactaceae Other Alkaloids Source classification Phenols Plants	Reference Standards Antibiotic
Hordenine (hydrochloride) (Standard) is the analytical standard of Hordenine (hydrochloride). This product is intended for research and analytical applications. Hordenine (hydrochloride), an alkaloid found in plants, inhibits melanogenesis by suppression of cyclic adenosine monophosphate (cAMP) production[1].

HY-N8092

Kushenol B	Flavonoids Classification of Application Fields Leguminosae Flavonones Source classification Phenols Polyphenols Plants Sophora flavescens Aiton Disease Research Fields Inflammation/Immunology	Phosphodiesterase (PDE)
Kushenol B is an isoprenoid flavonoid isolated from S. flavescens, has antimicrobial, anti-inflammatory and antioxidant activities . Kushenol B has inhibitory activity against cAMP phosphodiesterase (PDE), with an IC₅₀ of 31 µM .

HY-B1505

Acefylline 1 Publications Verification Theophyllineacetic acid; Theophylline-7-acetic acid	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Disease Research Fields Cancer	HDAC Adenosine Receptor Protein Arginine Deiminase Phosphodiesterase (PDE)
Acefylline, a xanthine derivative, is an adenosine receptor antagonist. Acefylline is a peptidylarginine deiminase (PAD) activator. Acefylline is also a bronchodilator and cardiac stimulant that inhibits rat lung cAMP phosphodiesterase isoenzymes. Acefylline can be used in asthma research .

HY-N3464

Isopedicin	Structural Classification Flavonoids Flavonones Source classification Plants Annonaceae Fissistigma oldhamii (Hemsl.) Merr.	Phosphodiesterase (PDE)
Isopedicin potently and concentration-dependently inhibits superoxide anion (O2 U?) production in formyl-L-methionyl-L-leucyl-L-phenylalanine (FMLP)-activated cells. Isopedicin increases cAMP formation and PKA activity in FMLP-activated cells by inhibiting phosphodiesterase (PDE) activity .

HY-W012980

Isovaleric acid	Structural Classification Classification of Application Fields Source classification Endocrine diseases Metabolic Disease Endogenous metabolite Biological Pesticide Research Agricultural Research Human Gut Microbiota Metabolites Immune System Disorder Microorganisms Ketones, Aldehydes, Acids Disease markers Disease Research Fields	Endogenous Metabolite AMPK PKA
Isovaleric acid is an oral active short-chain fatty acid that inhibits osteoclast differentiation by stimulating AMPK phosphorylation and promotes colonic smooth muscle relaxation by activating the *cAMP/PKA* pathway. Isovaleric acid can be used in research on skeletal diseases (such as osteoporosis) and intestinal disorders .

HY-N14663

Griseolic acid C Dihydrodeoxygriseolic acid	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source classification	Bacterial
Griseolic acid C (Dihydrodeoxygriseolic acid) is an antibiotic. Griseolic acid C can be found in Streptomyces griseoaurantiacus SANK43894. Griseolic acid C has the activity of inhibiting cyclic adenosine monophosphate (cAMP) phosphodiesterase [EC 3.1.4.17] with an IC₅₀ of 0.12 μM (extracted from rat brain) .

HY-N2168R

Pinoresinol 4-O-β-D-glucopyranoside (Standard) (+)-Pinoresinol 4-O-β-D-glucopyranoside (Standard)	Structural Classification Monophenols other families Source classification Lignans Phenols Phenylpropanoids Plants	Glycosidase Reference Standards Estrogen Receptor/ERR Phosphodiesterase (PDE)
Pinoresinol 4-O-β-D-glucopyranoside (Standard) is the analytical standard of Pinoresinol 4-O-β-D-glucopyranoside (HY-N2168). This product is intended for research and analytical applications. Pinoresinol 4-O-β-D-glucopyranoside is an orally active α-glucosidase inhibitor, with an IC₅₀ of 48.13 μg/mL. Pinoresinol 4-O-β-D-glucopyranoside binds to estrogen receptors. Pinoresinol 4-O-β-D-glucopyranoside inhibits phosphodiesterase. Pinoresinol 4-O-β-D-glucopyranoside exhibits various activities such as antioxidant, anti-inflammatory, anti-hyperglycemic, hepatoprotective and anti-epileptic effects .

HY-B1505R

Acefylline (Standard) Theophyllineacetic acid (Standard); Theophylline-7-acetic acid (Standard)	Structural Classification Ketones, Aldehydes, Acids Source classification Endogenous metabolite	HDAC Reference Standards Adenosine Receptor Protein Arginine Deiminase Phosphodiesterase (PDE)
Acefylline (Standard) is the analytical standard of Acefylline. This product is intended for research and analytical applications. Acefylline, a xanthine derivative, is an adenosine receptor antagonist. Acefylline is a peptidylarginine deiminase (PAD) activator. Acefylline is also a bronchodilator and cardiac stimulant that inhibits rat lung cAMP phosphodiesterase isoenzymes. Acefylline can be used in asthma research .

HY-N6901

Luteolin 7-sulfate	Structural Classification Flavonoids other families Classification of Application Fields Flavones Source classification Phenols Polyphenols Metabolic Disease Plants Disease Research Fields	Epigenetic Reader Domain
Luteolin 7-sulfate is isolated from Phyllospadix iwatensis Makino, a marine plant. Luteolin 7-sulfate attenuates TYR gene expression through the intervention of a cAMP-responsive element binding protein (CREB)- and microphthalmia-associated transcription factor (MITF)-mediated signaling pathway, leading to the decreased melanin synthesis .

HY-W012980R

Isovaleric acid (Standard)	Structural Classification Human Gut Microbiota Metabolites Immune System Disorder Microorganisms Ketones, Aldehydes, Acids Source classification Disease markers Endocrine diseases Endogenous metabolite	Reference Standards Endogenous Metabolite AMPK PKA
Isovaleric acid (Standard) is the analytical standard of Isovaleric acid. This product is intended for research and analytical applications. Isovaleric acid is an oral active short-chain fatty acid that inhibits osteoclast differentiation by stimulating AMPK phosphorylation and promotes colonic smooth muscle relaxation by activating the cAMP/PKA pathway. Isovaleric acid can be used in research on skeletal diseases (such as osteoporosis) and intestinal disorders .

HY-N6256

Ilexsaponin B2	Cardiovascular Disease Aquifoliaceae Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Ilex pubescens Hook. et Arn. Plants Disease Research Fields	Phosphodiesterase (PDE)
Ilexsaponin B2 is a saponin isolated from the root of Ilex pubescens Hook. et Arn. Ilexsaponin B2 is a potent phosphodiesterase 5 (PDE5) and PDEI inhibitor with IC₅₀ values of 48.8 μM and 477.5 μM, respectively .

HY-N0126

Xanthone 1 Publications Verification	Infection Structural Classification Xanthones Classification of Application Fields Guttiferae Source classification Phenols Garcinia mangostana Linn. Plants Inflammation/Immunology Disease Research Fields	Monoamine Oxidase Calcium Channel
Xanthone is a monoamine oxidase A (MAO-A) inhibitor with an IC₅₀ of 0.84 µM. Xanthon inhibits Norepinephrine (HY-13715) and high-K ⁺-induced vasoconstriction with IC₅₀ values of 60.26 μM and 82.9 μM, respectively. Xanthon increases intracellular cyclic adenosine 3′,5′-monophosphate (cAMP) content and blocks Ca ²⁺ channels. Xanthone is the scaffold of several pharmacologically active compounds .

HY-124151R

Adenosine-2'-monophosphate (Standard) 2'-AMP (Standard); Adenosine 2'-phosphate (Standard); AMP 2'-phosphate (Standard)	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Reference Standards Adenosine Receptor Endogenous Metabolite
Bisphenol A diglycidyl ether (Standard) is the analytical standard of Bisphenol A diglycidyl ether. This product is intended for research and analytical applications. Bisphenol A diglycidyl ether is used as a stabilizer and embedding agent.

HY-16558

Butein 4 Publications Verification 2’,3,4,4’-tetrahydroxy Chalcone	Structural Classification Chalcones Flavonoids other families Classification of Application Fields Anti-aging Source classification Phenols Polyphenols Plants Disease Research Fields Cancer	EGFR Autophagy Apoptosis Phosphodiesterase (PDE)
Butein is a cAMP-specific PDE inhibitor with an IC₅₀ of 10.4 μM for PDE4 . Butein is a specific protein tyrosine kinase inhibitor with IC₅₀s of 16 and 65 μM for EGFR and p60 ^c-src in HepG2 cells . Butein sensitizes HeLa cells to Cisplatin through AKT and ERK/p38 MAPK pathways by targeting FoxO3a . Butein is a SIRT1 activator (STAC).

HY-N0113A

Hordenine sulfate Ordenina sulfate; Peyocactine sulfate	Structural Classification Monophenols Gramineae Source classification Hordeum vulgare Phenols Plants	Antibiotic
Hordenine sulfate (Ordenina sulfate) is an active compound extracted from malted barley that has melanin-inhibiting activity. Hordenine sulfate significantly reduced melanin content and reduced intracellular cAMP levels. Hordenine sulfate inhibits the expression of proteins related to melanogenesis, including microblind transcription factor (MITF), tyrosinase, tyrosinase-related protein (TRP)-1, and TRP-2. Therefore, Hordenine sulfate can be used as an active ingredient to inhibit pigmentation .

HY-121793

Roemerine (-)-Roemerine	Structural Classification Aporphine Alkaloids Classification of Application Fields Fibraurea recisa Pierre Source classification Plants Menispermaceae Nymphaeaceae Alkaloids Nelumbo nucifera Gaertn. Isoquinoline Alkaloids Disease Research Fields Cancer	Endogenous Metabolite 5-HT Receptor mGluR iGluR Bacterial Antibiotic
Roemerine is an alkaloid that has been identified from the leaves of Fibraurea recisa Pierre. Roemerine exhibits antibacterial, anticancer, and antidepressant activities, can reverse the multidrug resistance phenotype in cultured cells, and exerts antibacterial effects by regulating the *cAMP* signaling pathway. Additionally, Roemerine influences neuronal activity by increasing BDNF protein expression and modulating the serotonergic and glutamatergic systems. Roemerine holds promise for research in the fields of cancer, infections, and neurological diseases .

HY-N3773

Dodoviscin A	Structural Classification Flavonoids Flavones Source classification Dodonaea viscosa (L.) Jacq. Sapindaceae Plants	Tyrosinase
Dodoviscin A is a pigmentation-altering agent, which can be isolated from the aerial parts of Dodonaea viscosa. Dodoviscin A inhibits melanin production in B16-F10 melanoma cells. Dodoviscin A suppresses mushroom tyrosinase activity, and tyrosinase activity induced by 3-isobutyl-1-methylxanthine. Dodoviscin A also inhibits the phorphosylation of cAMP response element binding protein, induced by 3-isobutyl-1-methylxanthine and forskolin .

HY-N2168

Pinoresinol 4-O-β-D-glucopyranoside 1 Publications Verification (+)-Pinoresinol 4-O-β-D-glucopyranoside	Cardiovascular Disease Structural Classification Monophenols other families Classification of Application Fields Source classification Lignans Phenols Phenylpropanoids Plants Disease Research Fields	Glycosidase Estrogen Receptor/ERR Phosphodiesterase (PDE)
Pinoresinol 4-O-β-D-glucopyranoside ((+)-Pinoresinol 4-O-β-D-glucopyranoside) is an orally active α-glucosidase inhibitor, with an IC₅₀ of 48.13 μg/mL. Pinoresinol 4-O-β-D-glucopyranoside binds to estrogen receptors. Pinoresinol 4-O-β-D-glucopyranoside inhibits phosphodiesterase. Pinoresinol 4-O-β-D-glucopyranoside exhibits various activities such as antioxidant, anti-inflammatory, anti-hyperglycemic, hepatoprotective and anti-epileptic effects .

HY-N8268R

Nordeoxycholic acid (Standard) 3α,12α-Dihydroxynorcholanic acid (Standard)	Animals Source classification	Drug Metabolite Reference Standards
Reproterol (hydrochloride) (Standard) is the analytical standard of Reproterol (hydrochloride). This product is intended for research and analytical applications. Reproterol hydrochloride is a dual-acting beta2-adrenoceptor agonist and phosphodiesterase inhibitor. Reproterol hydrochloride is more potent than albuterol and feterol in stimulating cAMP production in human monocytes, demonstrating its potential in enhancing airway function. Furthermore, Reproterol significantly inhibited the production of LTB4, indicating its anti-inflammatory properties. Reproterol hydrochloride may have inhibitory effects in respiratory diseases such as asthma and COPD .

HY-W040329

2'-Deoxyadenosine	Structural Classification Natural Products Immune System Disorder Classification of Application Fields Source classification Disease markers Other Diseases Endocrine diseases Nervous System Disorder Endogenous metabolite Disease Research Fields	Endogenous Metabolite Nucleoside Antimetabolite/Analog Caspase Apoptosis
2′-Deoxyadenosine is an adenine nucleoside that inhibits glucose-stimulated insulin release. 2′-Deoxyadenosine inhibits glucose-stimulated increases seen in islet cyclic AMP (cAMP) accumulation. 2'-Deoxyadenosine activates caspase-3 and promotes apoptosis. 2'-Deoxyadenosine inhibits the activity of S-adenosyl-L-homocysteine hydrolase (SAHH). 2'-Deoxyadenosine inhibits the growth of various cells. 2'-Deoxyadenosine has an anticancer effect on colon cancer .

HY-W011683

2'-Deoxyadenosine monohydrate	Natural Products Microorganisms Source classification Other Diseases Disease Research Fields	Endogenous Metabolite Nucleoside Antimetabolite/Analog Caspase Apoptosis
2′-Deoxyadenosine monohydrate is an adenine nucleoside that inhibits glucose-stimulated insulin release. 2′-Deoxyadenosine monohydrate inhibits glucose-stimulated increases seen in islet cyclic AMP (cAMP) accumulation. 2'-Deoxyadenosine monohydrate activates caspase-3 and promotes apoptosis. 2'-Deoxyadenosine monohydrate inhibits the activity of S-adenosyl-L-homocysteine hydrolase (SAHH). 2'-Deoxyadenosine monohydrate inhibits the growth of various cells. 2'-Deoxyadenosine monohydrate has an anticancer effect on colon cancer .

HY-N2118

Bilobetin 2 Publications Verification	Structural Classification Flavonoids Ginkgoaceae Classification of Application Fields Source classification Phenols Polyphenols Metabolic Disease Plants Biflavones Ginkgo biloba Disease Research Fields	PPAR PKA Akt p38 MAPK ERK
Bilobetin, an active component of Ginkgo biloba, can reduce blood lipids and improve the effects of insulin. Bilobetin ameliorated insulin resistance, increased the hepatic uptake and oxidation of lipids, reduced very-low-density lipoprotein triglyceride secretion and blood triglyceride levels, enhanced the expression and activity of enzymes involved in β-oxidation and attenuated the accumulation of triglycerides and their metabolites in tissues. Bilobetin also increased the phosphorylation, nuclear translocation and activity of PPARα accompanied by elevated cAMP level and PKA activity .

HY-16558R

Butein (Standard) 2’,3,4,4’-tetrahydroxy Chalcone (Standard)	Structural Classification Chalcones Flavonoids other families Source classification Phenols Polyphenols Plants	Reference Standards EGFR Autophagy Apoptosis Phosphodiesterase (PDE)
Butein (Standard) is the analytical standard of Butein. This product is intended for research and analytical applications. Butein is a cAMP-specific PDE inhibitor with an IC50 of 10.4 μM for PDE4 . Butein is a specific protein tyrosine kinase inhibitor with IC50s of 16 and 65 μM for EGFR and p60c-src in HepG2 cells . Butein sensitizes HeLa cells to Cisplatin through AKT and ERK/p38 MAPK pathways by targeting FoxO3a . Butein is a SIRT1 activator (STAC).

HY-N0126R

Xanthone (Standard) 1 Publications Verification	Infection Structural Classification Classification of Application Fields Guttiferae Source classification Phenols Garcinia mangostana Linn. Plants Inflammation/Immunology Disease Research Fields	Reference Standards Monoamine Oxidase Calcium Channel
Xanthone (Standard) is the analytical standard of Xanthone (HY-N0126). This product is intended for research and analytical applications. Xanthone is a monoamine oxidase A (MAO-A) inhibitor with an IC₅₀ of 0.84 µM. Xanthon inhibits Norepinephrine (HY-13715) and high-K ⁺-induced vasoconstriction with IC₅₀ values of 60.26 μM and 82.9 μM, respectively. Xanthon increases intracellular cyclic adenosine 3′,5′-monophosphate (cAMP) content and blocks Ca ²⁺ channels. Xanthone is the scaffold of several pharmacologically active compounds .

HY-121615

α-Phellandrene alpha-Phellandrene	Melaleuca alternifolia Structural Classification Other Monoterpenes Terpenoids Source classification Myrtaceae Plants	Insecticide Apoptosis Autophagy NO Synthase
α-Phellandrene (alpha-Phellandrene) is an orally active monoterpenoid and insecticide. α-Phellandrene can be isolated from plant essential oils. α-Phellandrene induces Apoptosis and Autophagy. α-Phellandrene promotes *cAMP* signaling pathway and increases NO production. α-Phellandrene has anti-inflammatory and anticancer (sarcoma) activities. α-Phellandrene shows insecticidal activity against Lucilia cuprina L3. α-Phellandrene reduces mechanical hyperalgesia .

HY-N6727

Gliotoxin Aspergillin	Structural Classification Anti-inflammation/Immunoregulatory Classification of Application Fields Source classification Antibacterial Disease Research Other Antibiotics Biological Pesticide Research Agricultural Research Infection Microorganisms Antibiotics Inflammation/Immunology Disease Research Fields	Apoptosis PKA NF-κB Bacterial Fungal Antibiotic
Gliotoxin is a secondary metabolite, the most abundant mycotoxin secreted by A. fumigatus, inhibits the phagocytosis of macrophages and the immune functions of other immune cells . Gliotoxin inhibits inducible NF-κB activity by preventing IκB degradation, which consequently induces host-cell apoptosis . Gliotoxin activates PKA and increases intracellular cAMP concentration; modulates actin cytoskeleton rearrangement to facilitate A. fumigatus internalization into lung epithelial cells . Gliotoxin is a potent NOTCH2 transactivation inhibitor, can effectively induce apoptosis of chronic lymphocytic leukemia (CLL) cells .

HY-N2118R

Bilobetin (Standard)	Structural Classification Flavonoids Ginkgoaceae Source classification Phenols Polyphenols Plants Biflavones Ginkgo biloba	Reference Standards PPAR PKA Akt p38 MAPK ERK
Bilobetin (Standard) is the analytical standard of Bilobetin. This product is intended for research and analytical applications. Bilobetin, an active component of Ginkgo biloba, can reduce blood lipids and improve the effects of insulin. Bilobetin ameliorated insulin resistance, increased the hepatic uptake and oxidation of lipids, reduced very-low-density lipoprotein triglyceride secretion and blood triglyceride levels, enhanced the expression and activity of enzymes involved in β-oxidation and attenuated the accumulation of triglycerides and their metabolites in tissues. Bilobetin also increased the phosphorylation, nuclear translocation and activity of PPARα accompanied by elevated cAMP level and PKA activity .

HY-124717

YC-001	Structural Classification Natural Products Classification of Application Fields Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
YC-001 is an inverse agonist and antagonist of rod opsin. YC-001 reversibly binds rod opsin and stabilizes the rod opsin structure. YC-001 protects mice from bright light-induced retinal degeneration. YC-001 has the potential for the research of retinal degeneration .

HY-N1860

3-O-Methylquercetin	Rhamnus nakaharai (Hayata) Hayata Structural Classification Flavonoids Classification of Application Fields Flavones Plants Rhamnaceae Inflammation/Immunology Disease Research Fields	Phosphodiesterase (PDE) NO Synthase
3-O-Methylquercetin is an inhibitor of *cAMP* and CGMP-phosphodiesterase (PDE) with IC₅₀ at 13.8 μM and 14.3 μM, respectively. 3-O-Methylquercetin is an inhibitor of β-secretase with an IC₅₀ of 6.5 μM. 3-O-Methylquercetin has a neuroprotective effect against neuronal death caused by oxidative damage. 3-O-Methylquercetin has strong antiviral activity against poliovirus, coxsackie virus and human rhinovirus. 3-O-Methylquercetin has anti-inflammatory and trachea-relaxing effects and can be used in the study of inflammatory diseases and asthma .

HY-W040329R

2'-Deoxyadenosine (Standard)	Structural Classification Natural Products Immune System Disorder Source classification Disease markers Endocrine diseases Nervous System Disorder Endogenous metabolite	Reference Standards Endogenous Metabolite Nucleoside Antimetabolite/Analog Caspase Apoptosis
2'-Deoxyadenosine (Standard) is the analytical standard of 2'-Deoxyadenosine (HY-W040329). This product is intended for research and analytical applications. 2′-Deoxyadenosine is an adenine nucleoside that inhibits glucose-stimulated insulin release. 2′-Deoxyadenosine inhibits glucose-stimulated increases seen in islet cyclic AMP (cAMP) accumulation. 2'-Deoxyadenosine activates caspase-3 and promotes apoptosis. 2'-Deoxyadenosine inhibits the activity of S-adenosyl-L-homocysteine hydrolase (SAHH). 2'-Deoxyadenosine inhibits the growth of various cells. 2'-Deoxyadenosine has an anticancer effect on colon cancer .

HY-W011683R

2'-Deoxyadenosine monohydrate (Standard)	Natural Products Microorganisms Source classification	Reference Standards Endogenous Metabolite Nucleoside Antimetabolite/Analog Caspase Apoptosis
2'-Deoxyadenosine monohydrate (Standard) is the analytical standard of 2'-Deoxyadenosine monohydrate ((HY-W011683). This product is intended for research and analytical applications. 2′-Deoxyadenosine monohydrate is an adenine nucleoside that inhibits glucose-stimulated insulin release. 2′-Deoxyadenosine monohydrate inhibits glucose-stimulated increases seen in islet cyclic AMP (cAMP) accumulation. 2'-Deoxyadenosine monohydrate activates caspase-3 and promotes apoptosis. 2'-Deoxyadenosine monohydrate inhibits the activity of S-adenosyl-L-homocysteine hydrolase (SAHH). 2'-Deoxyadenosine monohydrate inhibits the growth of various cells. 2'-Deoxyadenosine monohydrate has an anticancer effect on colon cancer .

HY-N2038

3,5,6,7,8,3',4'-Heptemthoxyflavone	Structural Classification Flavonols Flavonoids Rutaceae Plants Citrus reticulata Blanco	Phosphodiesterase (PDE)
3,5,6,7,8,3',4'-Heptemthoxyflavone, a flavonoid from satsuma peel, is an orally available CREB activator with anti-tumor and anti-neuroinflammatory activity. 3,5,6,7,8,3',4'-Heptemthoxyflavone inhibits collagenase activity and increases the content of type I procollagen in human dermal fibroblast neoblast (HDFn) cells. 3,5,6,7,8,3',4'-Heptemthoxyflavone induces brain-derived neurotrophic factor (BDNF) expression through the cAMP/ERK/CREB signaling pathway and reduces phosphodiesterase activity in C6 glioma .

HY-N3945R

Glaucine (Standard) O,O-Dimethylisoboldine (Standard); S-(+)-Glaucine (Standard); NSC 34396 (Standard)	Alkaloids Structural Classification other families Source classification Plants Isoquinoline Alkaloids Glaucium flavum Papaveraceae	Reference Standards Phosphodiesterase (PDE) Calcium Channel Adrenergic Receptor Dopamine Receptor Influenza Virus
Glaucine (Standard) is the analytical standard of Glaucine. This product is intended for research and analytical applications. Glaucine (O,O-Dimethylisoboldine) is an alkaloid isolated from Glaucium flavum with antitussive, bronchodilation and anti-inflammatory properties. Glaucine is a selective and orally active phosphodiesterase 4 (PDE4) inhibitor with Kis of 3.4 μM in human bronchus and polymorphonuclear leukocytes. Glaucine is also a non-selective α-adrenoceptor antagonist, a Ca2+ entry blocker, and a weak dopamine D1 and D2 receptor antagonist. Glaucine has antioxidative and antiviral activities .

HY-N3945

Glaucine O,O-Dimethylisoboldine; S-(+)-Glaucine; NSC 34396	Infection Alkaloids Structural Classification other families Classification of Application Fields Source classification Plants Isoquinoline Alkaloids Glaucium flavum Inflammation/Immunology Disease Research Fields Papaveraceae	Phosphodiesterase (PDE) Calcium Channel MMP NF-κB
Glaucine (O,O-Dimethylisoboldine) is an alkaloid extracted from Glaucium flavum that possesses various activities, including cough relief, bronchodilation, anti-inflammatory effects, analgesia, antipyretic properties, and anticancer effects. Glaucine acts as a selective and orally active inhibitor of phosphodiesterase 4 (PDE4), with a K_i of 3.4 µM in human bronchial tissues and polymorphonuclear leukocytes. Glaucine induces relaxation of human isolated bronchi by antagonizing calcium channels. Additionally, Glaucine inhibits the activation of NF-κB, leading to a reduction in the expression of the MMP-9 gene, thereby suppressing the migration and invasion of breast cancer cells. Therefore, Glaucine holds potential for research in asthma and breast cancer .

Cat. No.	Product Name	Chemical Structure

HY-B1511S

Cyclic AMP-13C5
Cyclic AMP- ¹³C₅ is a deuterated cyclic AMP.

HY-N0113S

Hordenine-d6
Hordenine-d6 (Ordenina-d6) is the deuterium labeled Hordenine. Hordenine, an alkaloid found in plants, inhibits melanogenesis by suppression of cyclic adenosine monophosphate (cAMP) production .

HY-135119

Salmeterol-d3
Salmeterol-d₃ is a deuterium labeled Salmeterol. Salmeterol is a potent and selective human β2 adrenoceptor agonist. Salmeterol shows potent stimulation of cAMP accumulation in CHO cells expressing human β2, β1 and β3 adrenoceptors with pEC₅₀s of 9.6, 6.1, and 5.9, respectively .

HY-14773S

(Rac)-Mirabegron-d5
(Rac)-Mirabegron-d₅ is a deuterium labeled (Rac)-Mirabegron. (Rac)-Mirabegron is the racemate of Mirabegron. Mirabegron is a selective β3-adrenoceptor agonist .

HY-14302S1

Salmeterol-d5
Salmeterol-d5 is a deuterated labeled Salmeterol . Salmeterol (GR33343X) is a potent and selective human β2 adrenoceptor agonist. Salmeterol shows potent stimulation of cAMP accumulation in CHO cells expressing human β2, β1 and β3 adrenoceptors with pEC₅₀s of 9.6, 6.1, and 5.9, respectively .

HY-17453S

Salmeterol-d3 xinafoate
Salmeterol-d₃ (xinafoate) is the deuterium labeled Salmeterol xinafoate. Salmeterol (GR 33343X) xinafoate is a potent and selective human β2 adrenoceptor agonist. Salmeterol shows potent stimulation of cAMP accumulation in CHO cells expressing human β2, β1 and β3 adrenoceptors with pEC₅₀s of 9.6, 6.1, and 5.9, respectively .

HY-12366S

Ubrogepant-d5
Ubrogepant-d₅ (MK-1602-d₅) is deuterium labeled Ubrogepant. Ubrogepant (MK-1602) is an orally active and selective antagonist of calcitonin gene-related peptide receptor (CGRP). Ubrogepant has high affinity for CGRP receptors in human and rhesus monkeys, and can effectively block the *cAMP* response stimulated by α-CGRP. Ubrogepant can be used in the study of acute migraine .

HY-17453S1

Salmeterol-13C6 xinafoate
Salmeterol- ¹³C₆ (xinafoate) is the ¹³C₆ labeled Salmeterol (xinafoate). Salmeterol (GR 33343X) xinafoate is a potent and selective human β2 adrenoceptor agonist. Salmeterol shows potent stimulation of cAMP accumulation in CHO cells expressing human β2, β1 and β3 adrenoceptors with pEC50s of 9.6, 6.1, and 5.9, respectively.

HY-19436S

Solabegron-d8
Solabegron-d₈ (GW 427353-d₈) is deuterium labeled Solabegron. Solabegron (GW 427353) is a selective β₃-adrenergic receptor agonist, stimulating cAMP accumulation in Chinese hamster ovary cells expressing the human β₃-AR, with an EC₅₀ value of 22 nM . Solabegron (GW 427353) is being developed for the treatment of overactive bladder and irritable bowel syndrome .

HY-B0679S

Lubiprostone-d7

Lubiprostone-d₇ (RU-0211-d7) is the deuterium labeled Lubiprostone. Lubiprostone (SPI-0211) increases intestinal fluid secretion through generation of CIC-2/CFTR and activation of cAMP signaling pathway. Lubiprostone inhibits myeloperoxidase (MPO) activity, downregulates Indomethacin (HY-14397)-induced iNOS and TNFα expression. Lubiprostone can be used for chronic constipation research .

HY-P0036S4

Octreotide-d8 acetate

Octreotide-d₈ (acetate) (SMS 201-995-d₈ (acetate)) is deuterium labeled Octreotide. Octreotide (SMS 201-995) is a somatostatin receptor agonist and synthetic octapeptide endogenous somatostatin analogue. Octreotide (SMS 201-995) can bind to the somatostatin receptor and mainly subtypes 2, 3, and 5, increases Gi activity, and reduces intracellular cAMP production. Octreotide (SMS 201-995) has antitumor activity, mediates apoptosis and may also be used in disease studies in acromegaly .

HY-P0036S2

Octreotide-d8

Octreotide-d₈ (SMS 201-995-d₈) is deuterium labeled Octreotide. Octreotide (SMS 201-995) is a somatostatin receptor agonist and synthetic octapeptide endogenous somatostatin analogue. Octreotide (SMS 201-995) can bind to the somatostatin receptor and mainly subtypes 2, 3, and 5, increases Gi activity, and reduces intracellular cAMP production. Octreotide (SMS 201-995) has antitumor activity, mediates apoptosis and may also be used in disease studies in acromegaly .

HY-P0036S3

Octreotide-13C9,15N

Octreotide- ¹³C₉, ¹⁵N (SMS 201-995- ¹³C₉, ¹⁵N) is ¹³C and ¹⁵N labeled Octreotide. Octreotide (SMS 201-995) is a somatostatin receptor agonist and synthetic octapeptide endogenous somatostatin analogue. Octreotide (SMS 201-995) can bind to the somatostatin receptor and mainly subtypes 2, 3, and 5, increases Gi activity, and reduces intracellular cAMP production. Octreotide (SMS 201-995) has antitumor activity, mediates apoptosis and may also be used in disease studies in acromegaly .

HY-W778207

2'-Deoxyadenosine-13C5 monohydrate

2'-Deoxyadenosine- ¹³C₅ monohydrate is the ¹³C labeled isotope of '-Deoxyadenosine monohydrate (HY-W040329). 2′-Deoxyadenosine is an adenine nucleoside that inhibits glucose-stimulated insulin release. 2′-Deoxyadenosine inhibits glucose-stimulated increases seen in islet cyclic AMP (cAMP) accumulation. 2'-Deoxyadenosine activates caspase-3 and promotes apoptosis. 2'-Deoxyadenosine inhibits the activity of S-adenosyl-L-homocysteine hydrolase (SAHH). 2'-Deoxyadenosine inhibits the growth of various cells. 2'-Deoxyadenosine has an anticancer effect on colon cancer .

HY-W745905

2'-Deoxyadenosine-15N1

2'-Deoxyadenosine- ¹⁵N₁ is the ¹⁵N-labeled 2'-Deoxyadenosine (HY-W040329). 2′-Deoxyadenosine is an adenine nucleoside that inhibits glucose-stimulated insulin release. 2′-Deoxyadenosine inhibits glucose-stimulated increases seen in islet cyclic AMP (cAMP) accumulation. 2'-Deoxyadenosine activates caspase-3 and promotes apoptosis. 2'-Deoxyadenosine inhibits the activity of S-adenosyl-L-homocysteine hydrolase (SAHH). 2'-Deoxyadenosine inhibits the growth of various cells. 2'-Deoxyadenosine has an anticancer effect on colon cancer .

HY-130304S

8-Isoprostaglandin E2-d4

8-Isoprostaglandin E2-d₄ (iPE2-III-d₄) is deuterium labeled 8-Isoprostaglandin E2. 8-Isoprostaglandin E2 (iPE2-III) is a member of the isoprostane class of prostanoids. 8-Isoprostaglandin E2 acts at the receptor for thromboxane A₂ (the TP) in vivo to induce vasoconstriction and platelet aggregation. 8-Isoprostaglandin E2 enhances receptor-activated NFkappa B ligand (RANKL)-dependent osteoclastic potential of marrow hematopoietic precursors via the cAMP pathway .

HY-W011683S7

2'-Deoxyadenosine monohydrate-15N5

2'-Deoxyadenosine monohydrate- ¹⁵N₅ is the ¹⁵N labeled 2'-Deoxyadenosine monohydrate (HY-W011683) . 2′-Deoxyadenosine monohydrate is an adenine nucleoside that inhibits glucose-stimulated insulin release. 2′-Deoxyadenosine monohydrate inhibits glucose-stimulated increases seen in islet cyclic AMP (cAMP) accumulation. 2'-Deoxyadenosine monohydrate activates caspase-3 and promotes apoptosis. 2'-Deoxyadenosine monohydrate inhibits the activity of S-adenosyl-L-homocysteine hydrolase (SAHH). 2'-Deoxyadenosine monohydrate inhibits the growth of various cells. 2'-Deoxyadenosine monohydrate has an anticancer effect on colon cancer .

HY-W011683S3

2'-Deoxyadenosine monohydrate-5′-13C

2'-Deoxyadenosine monohydrate-5′- ¹³C is the ¹³C labeled 2'-Deoxyadenosine monohydrate (HY-W011683) . 2′-Deoxyadenosine monohydrate is an adenine nucleoside that inhibits glucose-stimulated insulin release. 2′-Deoxyadenosine monohydrate inhibits glucose-stimulated increases seen in islet cyclic AMP (cAMP) accumulation. 2'-Deoxyadenosine monohydrate activates caspase-3 and promotes apoptosis. 2'-Deoxyadenosine monohydrate inhibits the activity of S-adenosyl-L-homocysteine hydrolase (SAHH). 2'-Deoxyadenosine monohydrate inhibits the growth of various cells. 2'-Deoxyadenosine monohydrate has an anticancer effect on colon cancer .

HY-W011683S

2'-Deoxyadenosine monohydrate-1′-13C

2'-Deoxyadenosine monohydrate-1′- ¹³C is the ¹³C labeled 2'-Deoxyadenosine monohydrate (HY-W011683) . 2′-Deoxyadenosine monohydrate is an adenine nucleoside that inhibits glucose-stimulated insulin release. 2′-Deoxyadenosine monohydrate inhibits glucose-stimulated increases seen in islet cyclic AMP (cAMP) accumulation. 2'-Deoxyadenosine monohydrate activates caspase-3 and promotes apoptosis. 2'-Deoxyadenosine monohydrate inhibits the activity of S-adenosyl-L-homocysteine hydrolase (SAHH). 2'-Deoxyadenosine monohydrate inhibits the growth of various cells. 2'-Deoxyadenosine monohydrate has an anticancer effect on colon cancer .

HY-W040329S2

2'-Deoxyadenosine-d13

2'-Deoxyadenosine-d₁₃ is deuterium labeled 2'-Deoxyadenosine (HY-W040329) . 2′-Deoxyadenosine is an adenine nucleoside that inhibits glucose-stimulated insulin release. 2′-Deoxyadenosine inhibits glucose-stimulated increases seen in islet cyclic AMP (cAMP) accumulation. 2'-Deoxyadenosine activates caspase-3 and promotes apoptosis. 2'-Deoxyadenosine inhibits the activity of S-adenosyl-L-homocysteine hydrolase (SAHH). 2'-Deoxyadenosine inhibits the growth of various cells. 2'-Deoxyadenosine has an anticancer effect on colon cancer .

HY-W011683S1

2'-Deoxyadenosine monohydrate-2′-13C

2'-Deoxyadenosine monohydrate-2′- ¹³C is the ¹³C labeled 2'-Deoxyadenosine monohydrate(HY-W011683) . 2′-Deoxyadenosine monohydrate is an adenine nucleoside that inhibits glucose-stimulated insulin release. 2′-Deoxyadenosine monohydrate inhibits glucose-stimulated increases seen in islet cyclic AMP (cAMP) accumulation. 2'-Deoxyadenosine monohydrate activates caspase-3 and promotes apoptosis. 2'-Deoxyadenosine monohydrate inhibits the activity of S-adenosyl-L-homocysteine hydrolase (SAHH). 2'-Deoxyadenosine monohydrate inhibits the growth of various cells. 2'-Deoxyadenosine monohydrate has an anticancer effect on colon cancer .

HY-W040329S1

2'-Deoxyadenosine-13C10

2'-Deoxyadenosine- ¹³C₁₀ is ¹³C-labeled 2'-Deoxyadenosine (HY-W040329) ^{. 2′-Deoxyadenosine is an adenine nucleoside that inhibits glucose-stimulated insulin release. 2′-Deoxyadenosine inhibits glucose-stimulated increases seen in islet cyclic AMP (cAMP) accumulation. 2'-Deoxyadenosine activates caspase-3 and promotes apoptosis. 2'-Deoxyadenosine inhibits the activity of S-adenosyl-L-homocysteine hydrolase (SAHH). 2'-Deoxyadenosine inhibits the growth of various cells. 2'-Deoxyadenosine has an anticancer effect on colon cancer ^.}

HY-W011683S2

2'-Deoxyadenosine monohydrate-3′-13C

2'-Deoxyadenosine monohydrate-3′- ¹³C is the ¹³C labeled 2'-Deoxyadenosine monohydrate (HY-W011683) ^{cAMP) accumulation. 2'-Deoxyadenosine monohydrate activates caspase-3 and promotes apoptosis. 2'-Deoxyadenosine monohydrate inhibits the activity of S-adenosyl-L-homocysteine hydrolase (SAHH). 2'-Deoxyadenosine monohydrate inhibits the growth of various cells. 2'-Deoxyadenosine monohydrate has an anticancer effect on colon cancer>}

HY-W040329S

2'-Deoxyadenosine-13C10,15N5

2'-Deoxyadenosine- ¹³C₁₀, ¹⁵N₅ is ¹³C and ¹⁵N-labeled 2'-Deoxyadenosine (HY-W040329) . 2′-Deoxyadenosine is an adenine nucleoside that inhibits glucose-stimulated insulin release. 2′-Deoxyadenosine inhibits glucose-stimulated increases seen in islet cyclic AMP (cAMP) accumulation. 2'-Deoxyadenosine activates caspase-3 and promotes apoptosis. 2'-Deoxyadenosine inhibits the activity of S-adenosyl-L-homocysteine hydrolase (SAHH). 2'-Deoxyadenosine inhibits the growth of various cells. 2'-Deoxyadenosine has an anticancer effect on colon cancer .

HY-W011683S6

2'-Deoxyadenosine monohydrate-13C10,15N5 hydrate

2'-Deoxyadenosine monohydrate- ¹³C₁₀, ¹⁵N₅ is the ¹³C and ¹⁵N labeled 2'-Deoxyadenosine monohydrate (HY-W011683) . 2′-Deoxyadenosine monohydrate is an adenine nucleoside that inhibits glucose-stimulated insulin release. 2′-Deoxyadenosine monohydrate inhibits glucose-stimulated increases seen in islet cyclic AMP (cAMP) accumulation. 2'-Deoxyadenosine monohydrate activates caspase-3 and promotes apoptosis. 2'-Deoxyadenosine monohydrate inhibits the activity of S-adenosyl-L-homocysteine hydrolase (SAHH). 2'-Deoxyadenosine monohydrate inhibits the growth of various cells. 2'-Deoxyadenosine monohydrate has an anticancer effect on colon cancer .

HY-W040329S3

2'-Deoxyadenosine-15N5,d13

2'-Deoxyadenosine- ¹⁵N₅,d₁₃ is deuterium and ¹⁵N labeled 2'-Deoxyadenosine (HY-W040329) . 2′-Deoxyadenosine is an adenine nucleoside that inhibits glucose-stimulated insulin release. 2′-Deoxyadenosine inhibits glucose-stimulated increases seen in islet cyclic AMP (cAMP) accumulation. 2'-Deoxyadenosine activates caspase-3 and promotes apoptosis. 2'-Deoxyadenosine inhibits the activity of S-adenosyl-L-homocysteine hydrolase (SAHH). 2'-Deoxyadenosine inhibits the growth of various cells. 2'-Deoxyadenosine has an anticancer effect on colon cancer .

HY-W767865

Cyclic GMP sodium-13C5

Cyclic GMP sodium- ¹³C₅ is the ¹³C-labeled Cyclic GMP sodium (HY-113469A). Cyclic GMP (cGAMP) sodium is an endogenous second messenger that triggers interferon production in response to cytoplasmic DNA. Cyclic GMP sodium can activate the stimulator of interferon genes (STING), activating the signaling cascade that leads to the production of type I interferons and other immune mediators. Cyclic-GMP-AMP, a conjugate of cyclic GMP and AMP, can induce IRF3 phosphorylation and nuclear translocation, enhancing antiviral immune responses. Cyclic GMP sodium may also activate PDE to degrade cAMP, inhibit myocardial calcium current ICa, and regulate myocardial contractility. The derivative of Cyclic GMP sodium, 8-Br-cGMP, has antiplatelet activity, and Cyclic GMP sodium can be used in the study of antiviral immunity and cardiovascular diseases .

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