Cathelicidin Antibody (YA4766)

Cathelicidin Antibody (YA4766) is a mouse-derived and non-conjugated monoclonal antibody, targeting to cAMP. It can be applicated for ELISA assays, in the background of species independent.

cAMP is an antimicrobial protein integral to the innate immune system, binding bacterial lipopolysaccharides (LPS) and enhancing CXCL2 release via neutrophil N-formyl peptide receptors. Postsecretory processing generates cathelicidin antimicrobial peptides of varying lengths, serving as topical antimicrobial defense in skin sweat. The unprocessed precursor, cathelicidin antimicrobial peptide, inhibits Gram-negative E. coli and E. aerogenes with efficiency comparable to the mature peptide LL-37 in vitro. It induces membrane permeabilization by forming transmembrane pores, lyses E. coli, and exhibits broad-spectrum antimicrobial activity against Gram-negative (e.g., P. aeruginosa, S. typhimurium, P. syringae), Gram-positive (e.g., L. monocytogenes, S. epidermidis, S. pyogenes, S. aureus), and vancomycin-resistant enterococci. In low-salt media, it is effective against methicillin-resistant S. aureus, P. mirabilis, and C. albicans but inactive in 100 mM NaCl. It forms chiral supramolecular assemblies with P. aeruginosa quorum-sensing signal (PQS), potentially disrupting biofilm formation, and induces cytokine/chemokine production (e.g., TNF/TNFA, CSF2/GMCSF) in keratinocytes. It also displays hemolytic activity against red blood cells. Synergistic action with peptides KS-30 and KR-31 enhances bactericidal effects against S. aureus, E. coli, and C. albicans at lower concentrations while maintaining activity under high-salt conditions, though it cannot stimulate CXCL8/IL8 release from keratinocytes. Similar functions include: antimicrobial activity against E. coli and B. megaterium and hemolysis; synergy with KR-20 and KR-31; and weak antibacterial effects (MIC > 150 µM) or poor activity against E. coli K12.

P49913

affinity purified.

Non-conjugated

Unmodified

Primary Antibody; Mouse Monoclonal Antibody

Monoclonal

Mouse

Species independent

ELISA: 1:10000

ELISA

Liquid

Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

cAMP, conjugated to KLH.