TORC3 Antibody (YA5086)

TORC3 Antibody (YA5086) is a mouse-derived and non-conjugated monoclonal antibody, targeting to TORC3. It can be applicated for WB, IHC-P, ICC/IF, ELISA assays, in the background of human, monkey.

CRTC3 is a transcriptional coactivator for CREB1, activating transcription through both consensus and variant cAMP response element (CRE) sites. It functions as a coactivator in the SIK/TORC signaling pathway, becoming active upon dephosphorylation and acting independently of CREB1 Ser-133 phosphorylation. CRTC3 enhances the interaction between CREB1 and TAF4 and regulates the expression of specific CREB-activated genes, such as the steroidogenic gene StAR. It is also a potent coactivator of PPARGC1A and an inducer of mitochondrial biogenesis in muscle cells. Additionally, CRTC3 serves as a coactivator for TAX-mediated activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). by similar: Its function is analogous to CRTC1 and CRTC2, both involved in CREB-dependent transcriptional regulation.

Q6UUV7

Predicted band size: 67 kDa;

affinity purified.

Non-conjugated

Unmodified

Primary Antibody; Mouse Monoclonal Antibody

Monoclonal

Mouse

Human, Monkey

WB: 1:500-1:2000; IHC: 1:200-1:1000; ICC/IF: 1:200-1:1000; ELISA: 1:10000

WB, IHC-P, ICC/IF, ELISA

Liquid

Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

Purified recombinant fragment of human TORC3 expressed in E. Coli.