2. Antibodies
  3. Primary Antibodies
  4. Monoclonal Antibodies Recombinant Antibodies
  5. ATF7 Antibody (YA2651)

ATF7 Antibody (YA2651)

Cat. No.: HY-P82906
User Guide for Antibodies Technical Support

ATF7 Antibody (YA2651) is a non-conjugated IgG antibody, targeting ATF7, with a predicted molecular weight of 52 kDa (observed band size: 52 kDa). ATF7 Antibody (YA2651) can be used for WB experiment in human, mouse, rat background.

For research use only. We do not sell to patients.

Size Price Stock Quantity
10 μL Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks
50 μL Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks
100 μL Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks
250 μL   Get quote  
Synthetic products have potential research and development risk.
or Bulk Inquiry

* Please select Quantity before adding items.

Top Publications Citing Use of Products

【WB: Western Blot; IHC-P: Immunohistochemistry-Paraffin; IHC-F: Immunohistochemistry-Frozen; ICC/IF: Immunocytochemistry/Immunofluorescence; IF-Tissue: Immunofluorescence-Tissue; mIHC: Multiplex Immunohistochemical; IP: Immunoprecipitation; ChIP: Chromatin Immunoprecipitation; FC: Flow Cytometry; ELISA: Enzyme Linked Immunosorbent Assay】

  • Biological Activity

  • Technical Parameters

  • Properties

  • Documentation

Description

ATF7 Antibody (YA2651) is a non-conjugated IgG antibody, targeting ATF7, with a predicted molecular weight of 52 kDa (observed band size: 52 kDa). ATF7 Antibody (YA2651) can be used for WB experiment in human, mouse, rat background.
Background

ATF7 is a stress-responsive chromatin regulator involved in various biological processes, including innate immunological memory, adipocyte differentiation, and telomerase regulation. Under non-stress conditions, it contributes to heterochromatin and heterochromatin-like structure formation by recruiting histone H3K9 tri- and di-methyltransferases, silencing target genes such as STAT1 in adipocytes or innate immunity-related genes in macrophages and adipocytes (by similarity). Stress-induced phosphorylation of ATF7 disrupts its interaction with histone methyltransferases and enhances association with coactivators containing histone acetyltransferases and/or demethylases, leading to heterochromatin-like structure disruption and subsequent transcriptional activation (by similarity). In response to TNF-alpha (induced by various stresses), phosphorylated ATF7 and telomerase are released from telomeres, resulting in telomere shortening. Additionally, ATF7 plays a role in maintaining epithelial regenerative capacity and protecting against cell death during intestinal epithelial damage and repair (by similarity). It acts as a dominant repressor of the E-selectin/NF-ELAM1/delta-A promoter and inhibits ATF2 and ATF7 transcriptional activities by sequestering Thr-53-phosphorylating kinase in the cytoplasm.
Gene ID
SwissProt ID
Synonyms
ATF7; ATFA; Cyclic AMP-dependent transcription factor ATF-7; cAMP-dependent transcription factor ATF-7; Activating transcription factor 7; Transcription factor ATF-A
Molecular Weight

Predicted band size: 52 kDa; Observed band size: 52 kDa
Purity

Affinity Chromatography
Conjugation

Non-conjugated
Modification

Unmodified
Research Field

Epigenetics and Nuclear Signaling
Product Categories

Primary Antibody; Recombinant Rabbit Monoclonal Antibody
Clonality

Recombinant, Monoclonal
Host

Rabbit
Reactivity

Human, Mouse, Rat
Dilution Ratio

WB: 1/500-1/1000
Application

WB
Appearance

Liquid
Formulation

Supplied in rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.
Isotype

IgG
Sensitivity

Endogenous
Immunogen

A synthesized peptide derived from human ATF7
Database

Entrez Gene: 11016 Human ; 223922 Mouse ; 315333 Rat

SwissProt: P17544 Human ; Q8R0S1 Mouse ;

OMIM: 606371 Human

Documentation
User Guide for Antibodies (1077 KB)

ATF7 Antibody (YA2651) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
ATF7 Antibody (YA2651)
Cat. No.:
HY-P82906
Quantity:
MCE Japan Authorized Agent:

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Country or Region *

Email Address *

     

Phone Number *

 

Organization Name *

Remarks

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.