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  4. Monoclonal Antibodies Recombinant Antibodies
  5. ATF7 Antibody (YA2651)

ATF7 Antibody (YA2651)

Cat. No.: HY-P82906
User Guide for Antibodies Technical Support

ATF7 Antibody (YA2651) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ATF7.

For research use only. We do not sell to patients.

Size Price Stock Quantity
10 μL Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks
50 μL Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks
100 μL Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks
250 μL   Get quote  
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Top Publications Citing Use of Products

【WB: Western Blot; IHC-P: Immunohistochemistry-Paraffin; IHC-F: Immunohistochemistry-Frozen; ICC/IF: Immunocytochemistry/Immunofluorescence; IF-Tissue: Immunofluorescence-Tissue; mIHC: Multiplex Immunohistochemical; IP: Immunoprecipitation; ChIP: Chromatin Immunoprecipitation; FC: Flow Cytometry; ELISA: Enzyme Linked Immunosorbent Assay】

  • Biological Activity

  • Technical Parameters

  • Properties

  • Documentation

Description

ATF7 Antibody (YA2651) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ATF7.
Background

ATF7 is a stress-responsive chromatin regulator involved in various biological processes, including innate immunological memory, adipocyte differentiation, and telomerase regulation. Under non-stress conditions, it contributes to heterochromatin and heterochromatin-like structure formation by recruiting histone H3K9 tri- and di-methyltransferases, silencing target genes such as STAT1 in adipocytes or innate immunity-related genes in macrophages and adipocytes (by similarity). Stress-induced phosphorylation of ATF7 disrupts its interaction with histone methyltransferases and enhances association with coactivators containing histone acetyltransferases and/or demethylases, leading to heterochromatin-like structure disruption and subsequent transcriptional activation (by similarity). In response to TNF-alpha (induced by various stresses), phosphorylated ATF7 and telomerase are released from telomeres, resulting in telomere shortening. Additionally, ATF7 plays a role in maintaining epithelial regenerative capacity and protecting against cell death during intestinal epithelial damage and repair (by similarity). It acts as a dominant repressor of the E-selectin/NF-ELAM1/delta-A promoter and inhibits ATF2 and ATF7 transcriptional activities by sequestering Thr-53-phosphorylating kinase in the cytoplasm.
Gene ID
SwissProt ID
Synonyms
ATF7; ATFA; Cyclic AMP-dependent transcription factor ATF-7; cAMP-dependent transcription factor ATF-7; Activating transcription factor 7; Transcription factor ATF-A
Molecular Weight

Predicted band size: 52 kDa; Observed band size: 52 kDa
Purity

Affinity Chromatography
Conjugation

Non-conjugated
Modification

Unmodified
Research Field

Epigenetics and Nuclear Signaling
Product Categories

Primary Antibody; Recombinant Rabbit Monoclonal Antibody
Clonality

Recombinant, Monoclonal
Host

Rabbit
Reactivity

Human, Mouse, Rat
Dilution Ratio

WB: 1:500-1:1000
Application

WB
Appearance

Liquid
Formulation

Supplied in rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.
Isotype

IgG
Sensitivity

Endogenous
Immunogen

A synthesized peptide derived from human ATF7
Database

Entrez Gene: 11016 Human ; 223922 Mouse ; 315333 Rat

SwissProt: P17544 Human ; Q8R0S1 Mouse ;

OMIM: 606371 Human

Documentation
User Guide for Antibodies (1077 KB)

ATF7 Antibody (YA2651) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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ATF7 Antibody (YA2651)
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HY-P82906
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