TORC1 Antibody (YA5170)

TORC1 Antibody (YA5170) is a mouse-derived and non-conjugated monoclonal antibody, targeting to TORC1. It can be applicated for WB, FC, ICC/IF assays, in the background of human, mouse, rat, pig.

CRTC1 is a transcriptional coactivator that activates transcription by interacting with CREB1, acting on both consensus and variant cAMP response element (CRE) sites. Within the SIK/TORC signaling pathway, CRTC1 functions as a coactivator, with its activity dependent on dephosphorylation and independent of CREB1 Ser-133 phosphorylation. It enhances the interaction between CREB1 and TAF4 and regulates the expression of specific CREB-activated genes, such as the steroidogenic gene StAR. CRTC1 is also a potent coactivator of PGC1alpha, inducing mitochondrial biogenesis in muscle cells. In the hippocampus, CRTC1 is involved in the maintenance of late-phase long-term potentiation (L-LTP) at Schaffer collateral-CA1 synapses. Additionally, CRTC1 may be essential for dendritic growth in developing cortical neurons (by similarity). CRTC1 collaborates with SIK1 to regulate light-induced entrainment of the circadian clock. Upon light stimulation, CRTC1 coactivates CREB-mediated transcription of PER1, which plays a critical role in the photic entrainment of the circadian clock. Furthermore, during microbial infection, CRTC1 acts as a coactivator for TAX-mediated activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR).

Q6UUV9

Predicted band size: 67 kDa;

affinity purified.

Non-conjugated

Unmodified

Primary Antibody; Mouse Monoclonal Antibody

Monoclonal

Mouse

Human, Mouse, Rat, Pig

WB: 1:1000-1:2000; FC: 1:100-1:200; ICC/IF: 1:100-1:500

WB, FC, ICC/IF

Liquid

Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

Purified recombinant human TORC1 (N-terminus) protein fragments expressed in E.coli.